IFI16

Summary

Gene Symbol: IFI16
Description: interferon gamma inducible protein 16
Alias: IFNGIP1, PYHIN2, gamma-interferon-inducible protein 16, interferon-gamma induced protein IFI 16, interferon-inducible myeloid differentiation transcriptional activator
Species: human
Products:     IFI16

Top Publications

  1. Shi X, Liu J, Liu Q, Li M. IFI16 mis-localization can be a contributing factor to hepatocellular carcinoma progression. Med Hypotheses. 2014;82:398-400 pubmed publisher
    ..However the mechanisms responsible for this phenomenon are poorly understood. Interferon-? inducible protein 16 (IFI16), a multifunctional protein, has roles in anti-proliferation, autophagy, cell senescence, anti-inflammation, and ..
  2. Borgogna C, Toniutto P, Smirne C, Azzimonti B, Rittà M, Avellini C, et al. Expression of the interferon-inducible proteins MxA and IFI16 in liver allografts. Histopathology. 2009;54:837-46 pubmed publisher
    ..Specimens were immunostained for two IFN-inducible proteins, MxA and IFI16, and for CD45...
  3. Li T, Chen J, Cristea I. Human cytomegalovirus tegument protein pUL83 inhibits IFI16-mediated DNA sensing for immune evasion. Cell Host Microbe. 2013;14:591-9 pubmed publisher
    ..We establish that the interferon-inducible protein IFI16 acts as a nuclear DNA sensor following HCMV infection, binding viral DNA and triggering expression of antiviral ..
  4. Orzalli M, Conwell S, Berrios C, DeCaprio J, Knipe D. Nuclear interferon-inducible protein 16 promotes silencing of herpesviral and transfected DNA. Proc Natl Acad Sci U S A. 2013;110:E4492-501 pubmed publisher
    ..We have found that nuclear interferon (IFN)-inducible protein 16 (IFI16) acts as a restriction factor against ICP0-null herpes simplex virus 1 (HSV-1) to limit viral replication and ..
  5. Aglipay J, Lee S, Okada S, Fujiuchi N, Ohtsuka T, Kwak J, et al. A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway. Oncogene. 2003;22:8931-8 pubmed
    We identified IFI16 as a BRCA1-associated protein involved in p53-mediated apoptosis. IFI16 contains the Pyrin/PAAD/DAPIN domain, commonly found in cell death-associated proteins...
  6. Veeranki S, Duan X, Panchanathan R, Liu H, Choubey D. IFI16 protein mediates the anti-inflammatory actions of the type-I interferons through suppression of activation of caspase-1 by inflammasomes. PLoS ONE. 2011;6:e27040 pubmed publisher
    ..Given that the IFI16 and AIM2 proteins are IFN-inducible and can heterodimerize with each other, we investigated the regulation of ..
  7. Clarke C, Apostolidis V, Hii L, Gough D, Trapani J, Johnstone R. Critical role of the transcription factor AP-1 for the constitutive and interferon-induced expression of IFI 16. J Cell Biochem. 2003;89:80-93 pubmed
    ..These experiments define the transcriptional mechanisms of IFI 16 gene regulation and provide evidence suggesting that AP-1 activation may be an important event in IFN signaling. ..
  8. Tawara H, Fujiuchi N, Sironi J, Martin S, Aglipay J, Ouchi M, et al. Loss of p53-regulatory protein IFI16 induces NBS1 leading to activation of p53-mediated checkpoint by phosphorylation of p53 SER37. Front Biosci. 2008;13:240-8 pubmed
    Our previous results that IFI16 is involved in p53 transcription activity under conditions of ionizing radiation (IR), and that the protein is frequently lost in human breast cancer cell lines and breast adenocarcinoma tissues suggesting ..
  9. Duan X, Ponomareva L, Veeranki S, Panchanathan R, Dickerson E, Choubey D. Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts. Mol Cancer Res. 2011;9:589-602 pubmed publisher
    The IFN-inducible IFI16 and AIM2 proteins act as innate immune sensors for cytosolic double-stranded DNA (dsDNA)...

More Information

Publications68

  1. Duan X, Ponomareva L, Veeranki S, Choubey D. IFI16 induction by glucose restriction in human fibroblasts contributes to autophagy through activation of the ATM/AMPK/p53 pathway. PLoS ONE. 2011;6:e19532 pubmed publisher
    ..Given that the activated p53 induces the expression of IFI16 protein, we investigated the potential role of the IFI16 protein in glucose restriction-induced responses...
  2. Jin T, Perry A, Jiang J, Smith P, Curry J, Unterholzner L, et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity. 2012;36:561-71 pubmed publisher
    ..AIM2 (absent in melanoma 2) and IFI16 (interferon-inducible protein 16) have been identified as DNA receptors that induce inflammasome formation and ..
  3. Li T, Diner B, Chen J, Cristea I. Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16. Proc Natl Acad Sci U S A. 2012;109:10558-63 pubmed publisher
    Detection of pathogenic nucleic acids is essential for mammalian innate immunity. IFN-inducible protein IFI16 has emerged as a critical sensor for detecting pathogenic DNA, stimulating both type I IFN and proinflammatory responses...
  4. Trapani J, Dawson M, Apostolidis V, Browne K. Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization. Immunogenetics. 1994;40:415-24 pubmed
    The human IFI16 gene is a member of an interferon-inducible family of mouse and human genes closely linked on syntenic regions of chromosome 1...
  5. Trapani J, Browne K, Dawson M, Ramsay R, Eddy R, Show T, et al. A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells. Immunogenetics. 1992;36:369-76 pubmed
    ..DNA blotting indicated that, in contrast to the mouse, IFI 16 is present as a single copy gene in the human genome. ..
  6. Song L, Ponomareva L, Shen H, Duan X, Alimirah F, Choubey D. Interferon-inducible IFI16, a negative regulator of cell growth, down-regulates expression of human telomerase reverse transcriptase (hTERT) gene. PLoS ONE. 2010;5:e8569 pubmed publisher
    Increased levels of interferon (IFN)-inducible IFI16 protein (encoded by the IFI16 gene located at 1q22) in human normal prostate epithelial cells and diploid fibroblasts (HDFs) are associated with the onset of cellular senescence...
  7. Orzalli M, DeLuca N, Knipe D. Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein. Proc Natl Acad Sci U S A. 2012;109:E3008-17 pubmed publisher
    ..We found that the interferon inducible protein 16 (IFI16) DNA sensor, which is required for induction of IRF-3 signaling in these cells, is nuclear, and its localization ..
  8. Gugliesi F, Bawadekar M, de Andrea M, Dell Oste V, Caneparo V, Tincani A, et al. Nuclear DNA sensor IFI16 as circulating protein in autoimmune diseases is a signal of damage that impairs endothelial cells through high-affinity membrane binding. PLoS ONE. 2013;8:e63045 pubmed publisher
    b>IFI16, a nuclear pathogenic DNA sensor induced by several pro-inflammatory cytokines, is a multifaceted protein with various functions...
  9. Kang H, Lee M, Kang H, Kim S, Ahn J, Na H, et al. Differential regulation of estrogen receptor ? expression in breast cancer cells by metastasis-associated protein 1. Cancer Res. 2014;74:1484-94 pubmed publisher
    ..encoding ERpro315 revealed that the transcription factor AP-2? (TFAP2C) and the IFN-?-inducible protein 16 (IFI16) were components of the complex...
  10. Gugliesi F, de Andrea M, Mondini M, Cappello P, Giovarelli M, Shoenfeld Y, et al. The proapoptotic activity of the Interferon-inducible gene IFI16 provides new insights into its etiopathogenetic role in autoimmunity. J Autoimmun. 2010;35:114-23 pubmed publisher
    ..Autoantibodies against the Interferon-inducible IFI16 protein, a member of the HIN-200 family constitutively expressed in endothelial cells and keratinocytes, have been ..
  11. Song L, Alimirah F, Panchanathan R, Xin H, Choubey D. Expression of an IFN-inducible cellular senescence gene, IFI16, is up-regulated by p53. Mol Cancer Res. 2008;6:1732-41 pubmed publisher
    IFN-inducible IFI16 protein (encoded by IFI16 gene at 1q23.1) is the human member of the IFN-inducible structurally related p200 family proteins...
  12. Choubey D, Panchanathan R. Interferon-inducible Ifi200-family genes in systemic lupus erythematosus. Immunol Lett. 2008;119:32-41 pubmed publisher
    ..of ISGs is the Ifi200-family, which includes mouse (Ifi202a, Ifi202b, Ifi203, Ifi204, and Ifi205) and human (IFI16, MNDA, AIM2, and IFIX) genes...
  13. Dawson M, Elwood N, Johnstone R, Trapani J. The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations. J Leukoc Biol. 1998;64:546-54 pubmed
    ..This differential expression of IFI 16 in myeloid precursor subpopulations and its perceived molecular properties are consistent with a possible role in regulating myelopoiesis. ..
  14. Alimirah F, Chen J, Davis F, Choubey D. IFI16 in human prostate cancer. Mol Cancer Res. 2007;5:251-9 pubmed
    Increased expression of IFI16 protein (encoded by the IFI16 gene) in normal human prostate epithelial cells is associated with cellular senescence-associated cell growth arrest...
  15. Gugliesi F, Mondini M, Ravera R, Robotti A, de Andrea M, Gribaudo G, et al. Up-regulation of the interferon-inducible IFI16 gene by oxidative stress triggers p53 transcriptional activity in endothelial cells. J Leukoc Biol. 2005;77:820-9 pubmed
    ..concentrations of H2O2 to p53 in primary human endothelial cells through the interferon (IFN)-inducible gene IFI16. Induction of IFI16 by H2O2 was concentration- and time-dependent (maximum at 50 microM, 6 h after treatment) and ..
  16. Kim E, Park J, Nelkin B. IFI16 is an essential mediator of growth inhibition, but not differentiation, induced by the leukemia inhibitory factor/JAK/STAT pathway in medullary thyroid carcinoma cells. J Biol Chem. 2005;280:4913-20 pubmed
    ..Here, we show that IFI16 is a necessary and sufficient downstream effector for LIF effects in MTC cells, specifically required for the LIF/..
  17. Ansari M, Singh V, Dutta S, Veettil M, Dutta D, Chikoti L, et al. Constitutive interferon-inducible protein 16-inflammasome activation during Epstein-Barr virus latency I, II, and III in B and epithelial cells. J Virol. 2013;87:8606-23 pubmed publisher
    ..association of a cytoplasmic sensor such as NLRP3 and AIM2 proteins or nuclear interferon-inducible protein 16 (IFI16) with adaptor ASC protein (apoptosis-associated speck-like protein with a caspase recruitment domain) and effector ..
  18. Brazda V, Coufal J, Liao J, Arrowsmith C. Preferential binding of IFI16 protein to cruciform structure and superhelical DNA. Biochem Biophys Res Commun. 2012;422:716-20 pubmed publisher
    ..b>IFI16 has been identified as a target of IFN? and ? and is a member of the HIN-200 protein family...
  19. Kondo Y, Nagai K, Nakahata S, Saito Y, Ichikawa T, Suekane A, et al. Overexpression of the DNA sensor proteins, absent in melanoma 2 and interferon-inducible 16, contributes to tumorigenesis of oral squamous cell carcinoma with p53 inactivation. Cancer Sci. 2012;103:782-90 pubmed publisher
    ..These analyses indicated that the absent in melanoma 2 (AIM2) gene and the interferon-inducible gene 16 (IFI16) mapped to the hematopoietic interferon-inducible nuclear proteins...
  20. Ouchi M, Ouchi T. Role of IFI16 in DNA damage and checkpoint. Front Biosci. 2008;13:236-9 pubmed
    b>IFI16 is a member of the HIN-200 family (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeat) that contains a DNA binding domain, a transcriptional regulatory domain, DAPIN/PAAD domain associated with ..
  21. Kwak J, Ongusaha P, Ouchi T, Lee S. IFI16 as a negative regulator in the regulation of p53 and p21(Waf1). J Biol Chem. 2003;278:40899-904 pubmed
    b>IFI16 is a member of the HIN-200 family (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) that contains a DNA binding domain, a transcriptional regulatory domain, and DAPIN/PAAD, a protein domain ..
  22. Kerur N, Veettil M, Sharma Walia N, Bottero V, Sadagopan S, Otageri P, et al. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe. 2011;9:363-75 pubmed publisher
    ..We demonstrate that during KSHV infection of endothelial cells, interferon gamma-inducible protein 16 (IFI16) interacts with the adaptor molecule ASC and procaspase-1 to form a functional inflammasome...
  23. Cristea I, Moorman N, Terhune S, Cuevas C, O Keefe E, Rout M, et al. Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol. 2010;84:7803-14 pubmed publisher
    ..We identified and confirmed the interaction of pUL83 with cellular IFI16 family members throughout the course of HCMV infection...
  24. Monroe K, Yang Z, Johnson J, Geng X, Doitsh G, Krogan N, et al. IFI16 DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV. Science. 2014;343:428-32 pubmed publisher
    ..short hairpin RNA-mediated gene knockdown in primary CD4 T cells, we identify interferon-γ-inducible protein 16 (IFI16) as a host DNA sensor required for CD4 T cell death due to abortive HIV infection...
  25. Sponza S, de Andrea M, Mondini M, Gugliesi F, Gariglio M, Landolfo S. Role of the interferon-inducible IFI16 gene in the induction of ICAM-1 by TNF-alpha. Cell Immunol. 2009;257:55-60 pubmed publisher
    The Interferon-inducible gene IFI16, a member of the HIN200 family, is activated by oxidative stress and cell density, in addition to Interferons, and it is implicated in the regulation of endothelial cell proliferation and vessel ..
  26. Egistelli L, Chichiarelli S, Gaucci E, Eufemi M, Schininà M, Giorgi A, et al. IFI16 and NM23 bind to a common DNA fragment both in the P53 and the cMYC gene promoters. J Cell Biochem. 2009;106:666-72 pubmed publisher
    ..2006] J. Cell. Biochem. 98:421-428). In a further study, we find now that IFI16, a transcriptional repressor, in both promoters binds to the G-rich fragment that also binds NM23/NDPK...
  27. Fujiuchi N, Aglipay J, Ohtsuka T, Maehara N, Sahin F, Su G, et al. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem. 2004;279:20339-44 pubmed
    b>IFI16 is a member of the PYRIN superfamily that has been implicated in BRCA1-mediated apoptosis and inflammation signaling pathways...
  28. Mazibrada J, de Andrea M, Rittà M, Borgogna C, Dell eva R, Pfeffer U, et al. In vivo growth inhibition of head and neck squamous cell carcinoma by the Interferon-inducible gene IFI16. Cancer Lett. 2010;287:33-43 pubmed publisher
    The Interferon-inducible gene, IFI16 has been implicated in the control of cell growth, apoptosis, angiogenesis and immunomodulation...
  29. Amrani Y, Tliba O, Choubey D, Huang C, Krymskaya V, Eszterhas A, et al. IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. Am J Physiol Lung Cell Mol Physiol. 2003;284:L1063-71 pubmed
  30. Unterholzner L, Keating S, Baran M, Horan K, Jensen S, Sharma S, et al. IFI16 is an innate immune sensor for intracellular DNA. Nat Immunol. 2010;11:997-1004 pubmed publisher
    ..Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-? (IFN-?)...
  31. Cuchet Louren o D, Anderson G, Sloan E, Orr A, Everett R. The viral ubiquitin ligase ICP0 is neither sufficient nor necessary for degradation of the cellular DNA sensor IFI16 during herpes simplex virus 1 infection. J Virol. 2013;87:13422-32 pubmed publisher
    The cellular protein IFI16 colocalizes with the herpes simplex virus 1 (HSV-1) ubiquitin ligase ICP0 at early times of infection and is degraded as infection progresses...
  32. Johnson K, Chikoti L, Chandran B. Herpes simplex virus 1 infection induces activation and subsequent inhibition of the IFI16 and NLRP3 inflammasomes. J Virol. 2013;87:5005-18 pubmed publisher
    ..Inflammasomes are comprised of cytoplasmic sensor molecules, such as NLRP3 and AIM2 or nuclear sensor IFI16, the adaptor protein ASC (apoptosis-associated speck-like protein containing CARD), and the effector protein ..
  33. Jakobsen M, Bak R, Andersen A, Berg R, Jensen S, Tengchuan J, et al. IFI16 senses DNA forms of the lentiviral replication cycle and controls HIV-1 replication. Proc Natl Acad Sci U S A. 2013;110:E4571-80 pubmed publisher
    ..This response was stimulated by stem regions in the DNA structure and was dependent on IFN-inducible protein 16 (IFI16), which bound immunostimulatory DNA directly and activated the stimulator of IFN genes -TANK-binding kinase 1 - ..
  34. Gariglio M, Azzimonti B, Pagano M, Palestro G, de Andrea M, Valente G, et al. Immunohistochemical expression analysis of the human interferon-inducible gene IFI16, a member of the HIN200 family, not restricted to hematopoietic cells. J Interferon Cytokine Res. 2002;22:815-21 pubmed
    This is the first description of an extensive immunohistochemical analysis of interferon (IFN)-inducible gene IFI16 expression in normal tissues...
  35. Xin H, Curry J, Johnstone R, Nickoloff B, Choubey D. Role of IFI 16, a member of the interferon-inducible p200-protein family, in prostate epithelial cellular senescence. Oncogene. 2003;22:4831-40 pubmed
    ..Collectively, our observations support the idea that increased levels of IFI 16 in PrECs contribute to senescence-associated irreversible cell growth arrest. ..
  36. Alimirah F, Chen J, Xin H, Choubey D. Androgen receptor auto-regulates its expression by a negative feedback loop through upregulation of IFI16 protein. FEBS Lett. 2006;580:1659-64 pubmed
    ..We report that re-expression of AR in PC-3 human prostate cancer cell line resulted in upregulation of IFI16 protein, a negative regulator of cell growth...
  37. Liao J, Lam R, Brazda V, Duan S, Ravichandran M, Ma J, et al. Interferon-inducible protein 16: insight into the interaction with tumor suppressor p53. Structure. 2011;19:418-29 pubmed publisher
    b>IFI16 is a member of the interferon-inducible HIN-200 family of nuclear proteins...
  38. Choubey D, Lengyel P. Binding of an interferon-inducible protein (p202) to the retinoblastoma protein. J Biol Chem. 1995;270:6134-40 pubmed
    ..The hypophosphorylated form of pRb binds to p202, p202 is the first interferon-inducible protein found to bind pRb. ..
  39. Johnstone R, Kerry J, Trapani J. The human interferon-inducible protein, IFI 16, is a repressor of transcription. J Biol Chem. 1998;273:17172-7 pubmed
    ..Thus, IFI 16 is a transcriptional repressor, with a modular structure typical of many known transcription regulators. ..
  40. Gariano G, Dell Oste V, Bronzini M, Gatti D, Luganini A, de Andrea M, et al. The intracellular DNA sensor IFI16 gene acts as restriction factor for human cytomegalovirus replication. PLoS Pathog. 2012;8:e1002498 pubmed publisher
    Human interferon (IFN)-inducible IFI16 protein, an innate immune sensor of intracellular DNA, modulates various cell functions, however, its role in regulating virus growth remains unresolved...
  41. Dell Oste V, Gatti D, Gugliesi F, de Andrea M, Bawadekar M, Lo Cigno I, et al. Innate nuclear sensor IFI16 translocates into the cytoplasm during the early stage of in vitro human cytomegalovirus infection and is entrapped in the egressing virions during the late stage. J Virol. 2014;88:6970-82 pubmed publisher
    ..We recently demonstrated that the DNA sensor IFI16 restricts human cytomegalovirus (HCMV) replication by downregulating viral early and late but not immediate-early ..
  42. Johnstone R, Wei W, Greenway A, Trapani J. Functional interaction between p53 and the interferon-inducible nucleoprotein IFI 16. Oncogene. 2000;19:6033-42 pubmed
    ..These findings demonstrate a possible link between gene induction following interferon stimulation and p53-mediated cellular events. ..
  43. Singh V, Kerur N, Bottero V, Dutta S, Chakraborty S, Ansari M, et al. Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes. J Virol. 2013;87:4417-31 pubmed publisher
    ..of endothelial cells, acting as a nuclear pattern recognition receptor, gamma interferon-inducible protein 16 (IFI16) colocalized with the KSHV genome in the nuclei and interacted with ASC and procaspase-1 to form a functional ..
  44. Yu F, Hao X, Zhao H, Ge C, Yao M, Yang S, et al. Delta-like 1 contributes to cell growth by increasing the interferon-inducible protein 16 expression in hepatocellular carcinoma. Liver Int. 2010;30:703-14 pubmed publisher
    ..DLK1 upregulated the expression of interferon-inducible protein 16 (IFI16) and its promoter transcriptional activity, decreased p21waf1/cip1 and induced cell cycle acceleration...
  45. Caposio P, Gugliesi F, Zannetti C, Sponza S, Mondini M, Medico E, et al. A novel role of the interferon-inducible protein IFI16 as inducer of proinflammatory molecules in endothelial cells. J Biol Chem. 2007;282:33515-29 pubmed
    The human IFI16 gene is an interferon-inducible gene implicated in the regulation of endothelial cell proliferation and tube morphogenesis...
  46. Choubey D, Deka R, Ho S. Interferon-inducible IFI16 protein in human cancers and autoimmune diseases. Front Biosci. 2008;13:598-608 pubmed
    Interferon-inducible IFI16 protein (encoded by IFI16 gene located at 1q21 region) is a member of the p200-protein family...
  47. Ansari M, Dutta S, Veettil M, Dutta D, Iqbal J, Kumar B, et al. Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses. PLoS Pathog. 2015;11:e1005019 pubmed publisher
    ..Recently, a predominantly nuclear gamma-interferon-inducible protein 16 (IFI16) involved in transcriptional regulation has emerged as an innate DNA sensor which induced IL-1β and IFN-β ..
  48. Shi X, Yang J, Mao N, Wu J, Ren L, Yang Y, et al. Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular carcinoma cells in vitro is associated with p53 activation. Acta Pharmacol Sin. 2015;36:252-8 pubmed publisher
    Interferon-γ inducible protein 16 (IFI16), a DNA sensor for DNA double-strand break (DSB), is expressed in most human hepatocellular carcinoma cell (HCC) lines...
  49. Dawson M, Trapani J. IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines. J Cell Biochem. 1995;57:39-51 pubmed
    ..Therefore, IFI 16 and MNDA are members of a novel family of human DNA-binding proteins whose expression is associated with myeloid cell differentiation induced by cytokines and chemical agents. ..
  50. Mazibrada J, Longo L, Vatrano S, Cappia S, Giorcelli J, Pentenero M, et al. Differential expression of HER2, STAT3, SOX2, IFI16 and cell cycle markers during HPV-related head and neck carcinogenesis. New Microbiol. 2014;37:129-43 pubmed
    ..In parallel, expression of pStat3, Sox2, IFI16 and p16, Ki67 was evaluated...
  51. Piccaluga P, Agostinelli C, Righi S, Ciccone M, Re M, Musumeci G, et al. IFI16 reduced expression is correlated with unfavorable outcome in chronic lymphocytic leukemia. APMIS. 2017;125:511-522 pubmed publisher
    ..In this paper, we show for the first time that the expression of the interferon-inducible DNA sensor IFI16, a member of the PYHIN protein family involved in proliferation inhibition and apoptosis regulation, is associated ..
  52. Hao B, Xiao Y, Song F, Long X, Huang J, Tian M, et al. Metformin-induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16. Int J Mol Med. 2018;41:1365-1376 pubmed publisher
    ..Through transfection with small interfering (si)RNA targeting p53 and interferon?inducible protein 16 (IFI16), the roles of p53 and IFI16 in these processes were evaluated...
  53. Briggs L, Johnstone R, Elliot R, Xiao C, Dawson M, Trapani J, et al. Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16. Biochem J. 2001;353:69-77 pubmed
  54. Bawadekar M, de Andrea M, Gariglio M, Landolfo S. Mislocalization of the interferon inducible protein IFI16 by environmental insults: implications in autoimmunity. Cytokine Growth Factor Rev. 2015;26:213-9 pubmed publisher
    The nuclear DNA sensor IFI16, a member of PYHIN family of proteins, was previously studied for its role in cell cycle regulation, tumor suppression, apoptosis and DNA damage signaling...
  55. Bawadekar M, de Andrea M, Lo Cigno I, Baldanzi G, Caneparo V, Graziani A, et al. The Extracellular IFI16 Protein Propagates Inflammation in Endothelial Cells Via p38 MAPK and NF-κB p65 Activation. J Interferon Cytokine Res. 2015;35:441-53 pubmed publisher
    The nuclear interferon-inducible-16 (IFI16) protein acts as DNA sensor in inflammasome signaling and as viral restriction factor...
  56. Horan K, Hansen K, Jakobsen M, Holm C, Søby S, Unterholzner L, et al. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol. 2013;190:2311-9 pubmed publisher
    ..Thus, proteasomal degradation of herpesvirus capsids releases DNA to the cytoplasm for recognition by DNA sensors...
  57. Ortiz Fernández L, García Lozano J, Montes Cano M, Conde Jaldón M, Ortego Centeno N, García Hernández F, et al. Variants of the IFI16 gene affecting the levels of expression of mRNA are associated with susceptibility to Behçet disease. J Rheumatol. 2015;42:695-701 pubmed publisher
    ..tag single nucleotide polymorphisms (tSNP) selected in 9 candidate genes (DDX58, IFIH1, TLR3, TLR7, TLR8, AIM2, IFI16, ZBP1, and TLR9) were genotyped in 371 patients and 854 controls...
  58. Everett R. Dynamic Response of IFI16 and Promyelocytic Leukemia Nuclear Body Components to Herpes Simplex Virus 1 Infection. J Virol. 2016;90:167-79 pubmed publisher
    ..Other cellular proteins, including IFI16, which has been implicated in sensing pathogen DNA and initiating signaling pathways that lead to an interferon ..
  59. Iqbal J, Ansari M, Kumar B, Dutta D, Roy A, Chikoti L, et al. Histone H2B-IFI16 Recognition of Nuclear Herpesviral Genome Induces Cytoplasmic Interferon-? Responses. PLoS Pathog. 2016;12:e1005967 pubmed publisher
    b>IFI16 (gamma-interferon-inducible protein 16), a predominantly nuclear protein involved in transcriptional regulation, also functions as an innate immune response DNA sensor and induces the IL-1? and antiviral type-1 interferon-? (IFN-?) ..