ID4

Summary

Gene Symbol: ID4
Description: inhibitor of DNA binding 4, HLH protein
Alias: IDB4, bHLHb27, DNA-binding protein inhibitor ID-4, class B basic helix-loop-helix protein 27, inhibitor of DNA binding 4, dominant negative helix-loop-helix protein, inhibitor of differentiation 4
Species: human
Products:     ID4

Top Publications

  1. Beger C, Pierce L, Kruger M, Marcusson E, Robbins J, Welcsh P, et al. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. Proc Natl Acad Sci U S A. 2001;98:130-5 pubmed
    ..The cellular target gene of one ribozyme was identified to be the dominant negative transcriptional regulator Id4. Modulation of Id4 expression resulted in inversely regulated expression of BRCA1...
  2. Bellido M, Aventin A, Lasa A, Estivill C, Carnicer M, Pons C, et al. Id4 is deregulated by a t(6;14)(p22;q32) chromosomal translocation in a B-cell lineage acute lymphoblastic leukemia. Haematologica. 2003;88:994-1001 pubmed
    ..Molecular cloning of the breakpoint revealed that this was located near the coding sequence of the Id4 gene, a helix-loop-helix (HLH) inhibitor protein...
  3. Chan A, Tsui W, Chen X, Chu K, Chan T, Chan A, et al. Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma. Oncogene. 2003;22:6946-53 pubmed
    ..Based on our published microarray expression data, we noticed a prominent downregulation of ID4 in gastric adenocarcinoma...
  4. Shan L, Yu M, Qiu C, Snyderwine E. Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. Am J Pathol. 2003;163:2495-502 pubmed
    b>Id4 belongs to a family of helix-loop-helix (HLH) proteins that impact cellular growth and differentiation via regulation of basic HLH transcription factors. Herein the rat Id4 gene was cloned (GenBank Accession No. AF468681)...
  5. Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu Y, et al. Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Nat Genet. 2005;37:265-74 pubmed
    ..We also identified Idb4 as a putative tumor-suppressor gene that is methylated in most mouse and human leukemias but in only a minority of ..
  6. Wu Q, Hoffmann M, Hartmann F, Schulz W. Amplification and overexpression of the ID4 gene at 6p22.3 in bladder cancer. Mol Cancer. 2005;4:16 pubmed
    ..We have therefore investigated whether the intermediate region harboring the oncogene candidate ID4 is also part of the amplicon...
  7. Jeon H, Sohn Y, Oh S, Oh S, Kim S, Beck S, et al. ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9*-mediated suppression of SOX2. Cancer Res. 2011;71:3410-21 pubmed publisher
    ..Our previous study has shown that inhibitor of differentiation 4 (ID4) dedifferentiates Ink4a/Arf(-/-) mouse astrocytes and human glioma cells to glioma stem-like ..
  8. Ruchusatsawat K, Wongpiyabovorn J, Protjaroen P, Chaipipat M, Shuangshoti S, Thorner P, et al. Parakeratosis in skin is associated with loss of inhibitor of differentiation 4 via promoter methylation. Hum Pathol. 2011;42:1878-87 pubmed publisher
    ..It occurs in many diseases of the skin, particularly in psoriasis. Down-regulation of inhibitor of differentiation 4 messenger RNA has been demonstrated in psoriatic skin, but the specificity and mechanism for this ..
  9. Knowell A, Patel D, Morton D, Sharma P, Glymph S, Chaudhary J. Id4 dependent acetylation restores mutant-p53 transcriptional activity. Mol Cancer. 2013;12:161 pubmed publisher
    ..Here we demonstrate that Id4, an HLH transcriptional regulator and a tumor suppressor, can restore the mutant p53 transcriptional activity in ..

More Information

Publications92

  1. Uhm K, Lee E, Lee Y, Park J, Kim S, Kim B, et al. Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia. J Korean Med Sci. 2009;24:493-7 pubmed publisher
    ..we identified the methylation status on one part of 5'CpG rich region of 8 genes, DAB2IP, DLC-1, H-cadherin, ID4, Integrin alpha4, RUNX3, SFRP1, and SHP1 in bone marrows from acute myeloid leukemia (AML) and chronic myeloid ..
  2. Lasorella A, Benezra R, Iavarone A. The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer. 2014;14:77-91 pubmed publisher
    ..The ability of ID proteins to function as central 'hubs' for the coordination of multiple cancer hallmarks has established these transcriptional regulators as therapeutic targets and biomarkers in specific types of human tumours. ..
  3. Divito K, Simbulan Rosenthal C, Chen Y, Trabosh V, Rosenthal D. Id2, Id3 and Id4 overcome a Smad7-mediated block in tumorigenesis, generating TGF-?-independent melanoma. Carcinogenesis. 2014;35:951-8 pubmed publisher
    ..We found that endogenous Id2, Id3 and Id4 expression was elevated in 1205Lu versus 1205Lu cells constitutively expressing Smad7, indicating Ids may play a ..
  4. Jeon H, Jin X, Lee J, Oh S, Sohn Y, Park H, et al. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev. 2008;22:2028-33 pubmed publisher
    ..Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM...
  5. Fontemaggi G, Dell Orso S, Trisciuoglio D, Shay T, Melucci E, Fazi F, et al. The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. Nat Struct Mol Biol. 2009;16:1086-93 pubmed publisher
    b>ID4 (inhibitor of DNA binding 4) is a member of a family of proteins that function as dominant-negative regulators of basic helix-loop-helix transcription factors...
  6. Noetzel E, Veeck J, Niederacher D, Galm O, Horn F, Hartmann A, et al. Promoter methylation-associated loss of ID4 expression is a marker of tumour recurrence in human breast cancer. BMC Cancer. 2008;8:154 pubmed publisher
    Inhibitor of DNA binding/Inhibitor of differentiation 4 (ID4) is a critical factor for cell proliferation and differentiation in normal vertebrate development...
  7. Pagliuca A, Bartoli P, Saccone S, Della Valle G, Lania L. Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. Genomics. 1995;27:200-3 pubmed
    ..We report here the cDNA sequence of a novel human HLH gene (HGMW-approved symbol ID4) that lacks the basic domain...
  8. Russell L, Akasaka T, Majid A, Sugimoto K, Loraine Karran E, Nagel I, et al. t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood. 2008;111:387-91 pubmed
    ..Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4...
  9. Wang H, Wang X, Xu X, Lin G. ID4 methylation predicts high risk of leukemic transformation in patients with myelodysplastic syndrome. Leuk Res. 2010;34:598-604 pubmed publisher
    ..Recent evidence demonstrated that ID4, a negative regulator of transcription, may act as a tumor-suppressor gene...
  10. Umetani N, Takeuchi H, Fujimoto A, Shinozaki M, Bilchik A, Hoon D. Epigenetic inactivation of ID4 in colorectal carcinomas correlates with poor differentiation and unfavorable prognosis. Clin Cancer Res. 2004;10:7475-83 pubmed
    b>ID4 gene is a member of the inhibitor of DNA binding (ID) family proteins that inhibit DNA binding of basic helix-loop-helix transcription factors...
  11. Sharma P, Chinaranagari S, Patel D, Carey J, Chaudhary J. Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer. Cancer Med. 2012;1:176-86 pubmed publisher
    ..On the contrary, our previous results demonstrated that Id4 acts as a potential tumor suppressor in prostate cancer...
  12. Wen Y, Ho A, Patil S, Akram M, Catalano J, Eaton A, et al. Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation. Breast Cancer Res Treat. 2012;135:93-102 pubmed publisher
    ..b>Id4, a helix-loop-helix DNA binding factor, blocks BRCA1 gene transcription in vitro and could downregulate BRCA1 in ..
  13. Chen S, Claus R, Lucas D, Yu L, Qian J, Ruppert A, et al. Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL. Blood. 2011;117:862-71 pubmed publisher
    Inhibitor of DNA binding protein 4 (ID4) is a member of the dominant-negative basic helix-loop-helix transcription factor family that lacks DNA binding activity and has tumor suppressor function...
  14. Carey J, Knowell A, Chinaranagari S, Chaudhary J. Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells. Anticancer Res. 2013;33:4271-8 pubmed
    ..In contrast to high Id1, Id2 and Id3 expression, the expression of Id4 is epigenetically silenced in prostate cancer...
  15. Noetzel E, Veeck J, Horn F, Hartmann A, Knuchel R, Dahl E. [Promoter methylation of ID4. A marker for recurrence-free survival in human breast cancer]. Pathologe. 2008;29 Suppl 2:319-27 pubmed publisher
    The aim of this study was to unravel the role of the transcription factor inhibitor of DNA binding 4 (ID4) in human breast carcinogenesis in more detail, especially the impact of ID4 promoter methylation on disease progression...
  16. Gómez del Pulgar T, Valdes Mora F, Bandres E, Pérez Palacios R, Espina C, Cejas P, et al. Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. Int J Oncol. 2008;33:185-93 pubmed
    ..Cdc42 levels through siRNA revealed that Cdc42 overexpression down-regulated the potential tumour suppressor gene ID4. Results were validated by quantitative RT-PCR and the methylation status of the specific promoter, analyzed...
  17. Hagiwara K, Nagai H, Li Y, Ohashi H, Hotta T, Saito H. Frequent DNA methylation but not mutation of the ID4 gene in malignant lymphoma. J Clin Exp Hematop. 2007;47:15-8 pubmed
    b>ID4 is a member of the inhibitor of DNA binding (ID) family, and inhibits the binding of basic helix-loop-helix transcription factors to DNA...
  18. Vinarskaja A, Goering W, Ingenwerth M, Schulz W. ID4 is frequently downregulated and partially hypermethylated in prostate cancer. World J Urol. 2012;30:319-25 pubmed publisher
    The candidate tumor suppressor ID4 is downregulated in various cancers by DNA hypermethylation. We have performed the first systematic analysis of ID4 expression and methylation in prostate cancer...
  19. Martini M, Cenci T, D Alessandris G, Cesarini V, Cocomazzi A, Ricci Vitiani L, et al. Epigenetic silencing of Id4 identifies a glioblastoma subgroup with a better prognosis as a consequence of an inhibition of angiogenesis. Cancer. 2013;119:1004-12 pubmed publisher
    Inhibitors of DNA binding/differentiation (Id1 to Id4) are a family of helix-loop-helix transcription factors, which are highly expressed during embryogenesis and at lower levels in mature tissues...
  20. Sachs C, Robinson B, Andres Martin L, Webster T, Gilbert M, Lo H, et al. Evaluation of candidate spermatogonial markers ID4 and GPR125 in testes of adult human cadaveric organ donors. Andrology. 2014;2:607-14 pubmed publisher
    ..the genes recently linked to SSCs in mice and other animals are the basic helix-loop-helix transcription factor ID4 and the orphan G-protein-coupled receptor GPR125...
  21. Hermann B, Mutoji K, Velte E, Ko D, Oatley J, Geyer C, et al. Transcriptional and translational heterogeneity among neonatal mouse spermatogonia. Biol Reprod. 2015;92:54 pubmed publisher
    ..However, P6 Id4-eGFP(+) transgenic spermatogonia, which are known to be enriched for SSCs, were more homogeneous in their mRNA ..
  22. Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J Biol Chem. 2002;277:9118-26 pubmed
    ..The ability of Id proteins to affect HES-1 activity is of particular interest in neuronal cells, where regulation of HES-1 is essential for the timing of neuronal differentiation. ..
  23. Chupeerach C, Kulanuwat S, Chuenta W, Wannaiampikul S, Schuh V, Preutthipan S, et al. ID4 gene polymorphism and osteoporosis in Thai menopausal women. J Med Assoc Thai. 2014;97:1004-8 pubmed
    The inhibitor of DNA binding 4 (ID4) protein regulates osteogenic and adipogenic cell fate and lack of lD4 gene expression decreased osteoblast differentiation. Variant in the ID4 gene polymorphism has not been reported with osteoporosis...
  24. Diotel N, Beil T, Strähle U, Rastegar S. Differential expression of id genes and their potential regulator znf238 in zebrafish adult neural progenitor cells and neurons suggests distinct functions in adult neurogenesis. Gene Expr Patterns. 2015;19:1-13 pubmed publisher
    ..We show that while id1 is exclusively expressed in ventricular cells in the whole brain, id2a, id3 and id4 genes are expressed in broader areas...
  25. Bellmunt J. Stem-Like Signature Predicting Disease Progression in Early Stage Bladder Cancer. The Role of E2F3 and SOX4. Biomedicines. 2018;6: pubmed publisher
    ..are highly expressed in patients with the chromosomal 6p22 amplification aside from other six well known genes (ID4, MBOAT1, LINC00340, PRL, and HDGFL1)...
  26. Chinaranagari S, Sharma P, Chaudhary J. EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer. Oncotarget. 2014;5:7172-82 pubmed
    Inhibitor of DNA binding/differentiation protein 4 (ID4) is dominant negative helix loop helix transcriptional regulator is epigenetically silenced due to promoter hyper-methylation in many cancers including prostate...
  27. Sun F, Xu Q, Zhao D, Degui Chen C. Id4 Marks Spermatogonial Stem Cells in the Mouse Testis. Sci Rep. 2015;5:17594 pubmed publisher
    ..Here, we generated a knock-in mouse model, Id4-2A-CreERT2-2A-tdTomato, which allowed us to mark Id4-expressing (Id4(+)) cells at different time points in situ and ..
  28. Shang M, Su B, Lipke E, Perera D, Li C, Qin Z, et al. Spermatogonial stem cells specific marker identification in channel catfish, Ictalurus punctatus and blue catfish, I. furcatus. Fish Physiol Biochem. 2015;41:1545-56 pubmed publisher
    ..In contrast to channel catfish, Id4, Smad5 and Prdm14 gene expressions were strongly down-regulated in spermatocyte cells, but up-regulated in ..
  29. Weng C, Nguyen T, Shively J. miRNA-342 Regulates CEACAM1-induced Lumen Formation in a Three-dimensional Model of Mammary Gland Morphogenesis. J Biol Chem. 2016;291:16777-86 pubmed publisher
    ..In fact, overexpression of miR-342 in MCF7/CEACAM1 cells significantly blocked lumen formation (p < 0.001). ID4, a dominant-negative inhibitor of basic helix-loop-helix transcription factors, up-regulated in MCF7/CEACAM1 cells, ..
  30. Zhang T, OATLEY J, Bardwell V, Zarkower D. DMRT1 Is Required for Mouse Spermatogonial Stem Cell Maintenance and Replenishment. PLoS Genet. 2016;12:e1006293 pubmed publisher
    ..Committed progenitor cells expressing Ngn3 normally do not contribute to SSCs marked by the Id4-Gfp transgene, but do so when spermatogonia are chemically depleted using busulfan...
  31. Joshi J, Patel D, Morton D, Sharma P, Zou J, Hewa Bostanthirige D, et al. Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52. Mol Oncol. 2017;11:337-357 pubmed publisher
    ..We have shown that inactivation of inhibitor of differentiation 4 (ID4), a dominant-negative helix loop helix protein, promotes de novo steroidogenesis and CRPC with ..
  32. Zhao Y, Jing Y, Bo J, Wang S, Wang Q, Li H, et al. [Significance of id4 gene promoter methylation detection in lymphoma]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16:322-4 pubmed
    The aim of this study was to evaluate the significance of id4 gene promotor methylation detection in NHL patients. MS-PCR method was used to detect the status of id4 gene methylation in health donors and newly diagnosed NHL patients...
  33. Zhao Y, Wang Q, Li H, Jing Y, Bo J, Wang S, et al. [Methylation of Id4 gene promoter in 4 malignant hematopoietic cell lines]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16:1418-20 pubmed
    This study was purposed to investigate the status of Id4 gene promoter methylation in malignant hematologic cell lines. MS-PCR methods were used to detect the status of Id4 gene methylation in K562, HL-60, Ramous and CA46...
  34. Shen Y, Zhang J, Yu T, Qi C. Generation of PTEN knockout bone marrow mesenchymal stem cell lines by CRISPR/Cas9-mediated genome editing. Cytotechnology. 2018;70:783-791 pubmed publisher
    ..The expression of Id4, Runx2, ALP and PPARγ was examined by qPCR and immunocytochemistry staining...
  35. Church J, Kigerl K, Lerch J, Popovich P, McTigue D. TLR4 Deficiency Impairs Oligodendrocyte Formation in the Injured Spinal Cord. J Neurosci. 2016;36:6352-64 pubmed publisher
    ..OL genesis, including reduced NG2 expression, fewer BrdU-positive OLs, altered BMP4 signaling and inhibitor of differentiation 4 (ID4) expression, and delayed myelin phagocytosis...
  36. Wu T, Trahair L, Little T, Bound M, Zhang X, Wu H, et al. Effects of Vildagliptin and Metformin on Blood Pressure and Heart Rate Responses to Small Intestinal Glucose in Type 2 Diabetes. Diabetes Care. 2017;40:702-705 pubmed publisher
    ..vildagliptin (50 mg) and placebo, given 60 min before a 120-min ID glucose infusion at 2 or 4 kcal/min (ID2 or ID4) in 16 patients...
  37. Zhou J, Zhang T, Li X, Ma J, Guo H, Wen X, et al. Epigenetic dysregulation of ID4 predicts disease progression and treatment outcome in myeloid malignancies. J Cell Mol Med. 2017;21:1468-1481 pubmed publisher
    Promoter hypermethylation-mediated inactivation of ID4 plays a crucial role in the development of solid tumours. This study aimed to investigate ID4 methylation and its clinical relevance in myeloid malignancies...
  38. Lim R, Tan A, Liu Y, Barathi V, Mohan R, Mehta J, et al. ITF2357 transactivates Id3 and regulate TGFβ/BMP7 signaling pathways to attenuate corneal fibrosis. Sci Rep. 2016;6:20841 pubmed publisher
    ..with ITF2357 activated BMP7 levels and expressed all the members of inhibitor of differentiation proteins (Id1-Id4), however, it failed to rescue TGFβ-driven transdifferentiation of fibroblasts to myofibroblasts in the presence ..
  39. Gopinath C, Law W, Rodriguez Molina J, Prasad A, Song L, Crawford G, et al. Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation. BMC Genomics. 2016;17:887 pubmed
    ..map to loci involved in the negative regulation of gliogenesis including SOX5, SOX6, NOTCH1, HMGA2, HES1, MYCN, ID4, and ID2...
  40. Morton D, Patel D, Joshi J, Hunt A, Knowell A, Chaudhary J. ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation. Oncotarget. 2017;8:2536-2549 pubmed publisher
    ..Using p53 null prostate cancer cell line we show that ID4 dependent acetylation promotes mutant p53 DNA-binding capabilities to its wild type consensus sequence, thus ..
  41. Agboola A, Ebili H, Iyawe V, Banjo A, Salami B, Rakha E, et al. Tumour cell membrane laminin expression is associated with basal-like phenotype and poor survival in Nigerian breast cancer. Malays J Pathol. 2016;38:83-92 pubmed
    ..005), premenopausal status (p=0.003), expression of EGFR (p=0.002), ID4 and MTA1, basal cytokeratin 5/6, p53, and triple negative tumours (all p<0.001)...
  42. Piai A, Calçada E, Tarenzi T, Grande A, Varadi M, Tompa P, et al. Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy. Biophys J. 2016;110:372-381 pubmed publisher
    Here, we present a structural and dynamic description of CBP-ID4 at atomic resolution. ID4 is the fourth intrinsically disordered linker of CREB-binding protein (CBP)...
  43. Peretz Y, Wu H, Patel S, Bellacosa A, Katz R. Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells. PLoS ONE. 2015;10:e0116839 pubmed publisher
    ..to development and neural stem cell biology, which included SRY-box 2 (SOX2) and Inhibitor of DNA Binding 4 (ID4). A gene set related to cancer cell motility and invasiveness was concomitantly downregulated...
  44. Lord T, Oatley J. A revised Asingle model to explain stem cell dynamics in the mouse male germline. Reproduction. 2017;154:R55-R64 pubmed publisher
    ..i>eGfp) that reflects expression of the SSC-specific transcription factor 'inhibitor of DNA binding 4' (Id4), we propose a revised version of the traditional model in which SSCs are a subset of the Asingle ..
  45. Ahuja S, Dogra D, Stainier D, Reischauer S. Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development. Dev Biol. 2016;412:71-82 pubmed publisher
    ..Here we identify a new role for the basic helix-loop-helix factor Id4 in zebrafish AVC valve development and function...
  46. Kitagaki J, Miyauchi S, Asano Y, Imai A, Kawai S, Michikami I, et al. A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population. PLoS ONE. 2016;11:e0160765 pubmed publisher
    ..genes was through the GPR126-induced increase of bone morphogenic protein-2, inhibitor of DNA binding (ID) 2, and ID4 expression...
  47. Nguyen N, de Oliveira Andrade F, Jin L, Zhang X, Macon M, Cruz M, et al. Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice. Breast Cancer Res. 2017;19:77 pubmed publisher
    ..cancer risk (ANKEF1, IGFBP6, SEMA5B), increased resistance to cancer treatments (SLC26A3), poor prognosis (ID4, JAM3, TBX2), and impaired anticancer immunity (EGR3, ZBP1)...
  48. Miyata K, Miyata T, Nakabayashi K, Okamura K, Naito M, Kawai T, et al. DNA methylation analysis of human myoblasts during in vitro myogenic differentiation: de novo methylation of promoters of muscle-related genes and its involvement in transcriptional down-regulation. Hum Mol Genet. 2015;24:410-23 pubmed publisher
    ..Sequence motif analysis identified 8-bp motifs somewhat similar to the binding motifs of ID4 and ZNF238 to be most significantly enriched in hypermethylated promoter regions...
  49. Kim S, Kelland E, Kim J, Lund B, Chang X, Wang K, et al. The influence of retinoic acid on the human oligodendrocyte precursor cells by RNA-sequencing. Biochem Biophys Rep. 2017;9:166-172 pubmed publisher
    ..differentiation: Hes5 following prolonged treatment with all-trans-RA, 9-cis RA and 13-cis RA; and Id4 following treatment with 13cisRA...
  50. Sullivan J, Havrda M, Kettenbach A, Paolella B, Zhang Z, Gerber S, et al. Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells. Stem Cells. 2016;34:1321-31 pubmed publisher
    Inhibitor of DNA binding proteins (Id1-Id4) function to inhibit differentiation and promote proliferation of many different cell types...
  51. Gao X, Zhao W, Wang G, Cui M, Zhang Y, Li W. Inhibitor of DNA binding 4 functions as a tumor suppressor and is targetable by 5-aza-2'-deoxycytosine with potential therapeutic significance in Burkitt's lymphoma. Mol Med Rep. 2016;13:1269-74 pubmed publisher
    ..One important target for gene methylation analysis in non-Hodgkin lymphoma (NHL) is inhibitor of DNA binding 4 (ID4)...
  52. Kang H, Wang X, Gao L, Cen J, Li M, Wang W, et al. Clinical implications of the quantitative detection of ID4 gene methylation in myelodysplastic syndrome. Eur J Med Res. 2015;20:16 pubmed publisher
    ..Hypermethylation of the inhibitor of DNA binding 4 (ID4) gene may play an important role in the initiation and development of MDS and AL...
  53. Zhang Y, Zhang B, Fang J, Cao X. Hypomethylation of DNA-binding inhibitor 4 serves as a potential biomarker in distinguishing acquired tamoxifen-refractory breast cancer. Int J Clin Exp Pathol. 2015;8:9500-5 pubmed
    To explore the methylation status of DNA-binding inhibitor 4 (ID4) in tamoxifen-refractory (TR) breast cancer...
  54. Cui X, Wang J, Liu K, Cui S, Zhang J, Luo Y, et al. Role of heteroplasmic mutations in the mitochondrial genome and the ID4 gene promoter methylation region in the pathogenesis of chronic aplastic anemia in patients suffering from Kidney yin deficiency. Chin J Integr Med. 2016;22:412-9 pubmed publisher
    To analyze changes in gene amplification in the mitochondrial genome and in the ID4 gene promoter methylation region in patients with chronic aplastic anemia (CAA) suffering from Kidney (Shen) yin deficiency or Kidney yang deficiency...
  55. Peddada S, Yasui D, LaSalle J. Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet. 2006;15:2003-14 pubmed
    ..all four known members of the inhibitors of differentiation or inhibitors of DNA-binding (ID1, ID2, ID3 and ID4) subfamily of helix-loop-helix genes as novel neuronal targets of MeCP2...
  56. Divito K, Trabosh V, Chen Y, Simbulan Rosenthal C, Rosenthal D. Inhibitor of differentiation-4 (Id4) stimulates pigmentation in melanoma leading to histiocyte infiltration. Exp Dermatol. 2015;24:101-7 pubmed publisher
    ..suppress melanomagenesis; however, little work examining Ids has been reported in melanoma, particularly for Id4. Here, we report that Id4, but not Id2 or Id3 expression, surprisingly, activated robust melanin production in ..
  57. Patel D, Knowell A, Korang Yeboah M, Sharma P, Joshi J, Glymph S, et al. Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer. Mol Endocrinol. 2014;28:1239-53 pubmed publisher
    ..Our studies have shown that genetic ablation of inhibitor of differentiation 4 (Id4), a dominant-negative helix loop helix protein, in mice results in prostatic intraepithelial ..
  58. Zhao Y, Wang Q, Li H, Bo J, Dou L, Jing Y, et al. [Significance of id4 promoter methylation in monitoring AML patients with completely remission]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16:476-8 pubmed
    The study was purposed to investigate the significance of id4 gene promoter methylation in monitoring AML patients with complete remission (CR)...
  59. Boareto M, Iber D, Taylor V. Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation. Development. 2017;144:3465-3474 pubmed publisher
    ..During brain development, Notch signaling dominates and directly regulates Id4 expression, preventing other ID factors from inducing NSC quiescence...
  60. Agrimson K, Oatley M, Mitchell D, Oatley J, Griswold M, Hogarth C. Retinoic acid deficiency leads to an increase in spermatogonial stem number in the neonatal mouse testis, but excess retinoic acid results in no change. Dev Biol. 2017;432:229-236 pubmed publisher
    ..Whole mount immunofluorescence and flow cytometric analysis using the Id4-eGfp transgenic reporter mouse line revealed an enrichment for ID4-EGFP+ cells within the testis following ..
  61. Sharma P, Knowell A, Chinaranagari S, Komaragiri S, Nagappan P, Patel D, et al. Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN. Mol Cancer. 2013;12:67 pubmed publisher
    b>Inhibitor of differentiation 4 (Id4), a member of the helix-loop-helix family of transcriptional regulators has emerged as a tumor suppressor in prostate cancer...
  62. Choy L, Hagenbeek T, Solon M, French D, Finkle D, Shelton A, et al. Constitutive NOTCH3 Signaling Promotes the Growth of Basal Breast Cancers. Cancer Res. 2017;77:1439-1452 pubmed publisher
    ..signature that included Notch pathway components, the oncogene c-Myc, and the mammary stem cell regulator Id4 This signature drove clustering of breast cancer cell lines and tumors into the common subtypes and correlated ..
  63. Loveys D, Streiff M, Kato G. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res. 1996;24:2813-20 pubmed
    ..Four murine cDNAs were identified in the screen, all of which encode helix-loop-helix proteins: E12, E47, ALF1 and Id4. Co-immunoprecipitation assays confirm that Id3 interacts with E12, E47 and two alternative splice products of ALF1 ..
  64. Galardi S, Savino M, Scagnoli F, Pellegatta S, Pisati F, Zambelli F, et al. Resetting cancer stem cell regulatory nodes upon MYC inhibition. EMBO Rep. 2016;17:1872-1889 pubmed
    ..identity such as OLIG2, POU3F2, SOX2, upregulation of effectors of tumour suppression and differentiation such as ID4, MIAT, PTEN, and modulation of the expression of microRNAs that target molecules implicated in glioblastoma growth ..
  65. Saied M, Marzec J, Khalid S, Smith P, Down T, Rakyan V, et al. Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats. PLoS ONE. 2012;7:e33213 pubmed publisher
    ..MeDIP-seq data were validated using bisulfite pyrosequencing and the Infinium array. ..
  66. Baker L, Holliday H, Swarbrick A. ID4 controls luminal lineage commitment in normal mammary epithelium and inhibits BRCA1 function in basal-like breast cancer. Endocr Relat Cancer. 2016;23:R381-92 pubmed publisher
    ..One member of this family, ID4, controls lineage commitment during mammary gland development by acting upstream of key developmental pathways...
  67. Albertsen H, Chettier R, Farrington P, Ward K. Genome-wide association study link novel loci to endometriosis. PLoS ONE. 2013;8:e58257 pubmed publisher
    ..51×10(-7) we identify two additional loci in our meta-analysis that associate with endometriosis:, RNF144B-ID4 on 6p22.3 (rs6907340; P?=?2.19×10(-7), OR?=?1.20, Cl?=?1.12-1.28), and HNRNPA3P1-LOC100130539 on 10q11...
  68. Cen J, Shen J, Wang X, Kang H, Wang L, Sun L, et al. Association between lymphoma prognosis and aberrant methylation of ID4 and ZO-1 in bone marrow and paraffin-embedded lymphoma tissues of treatment-naive patients. Oncol Rep. 2013;30:455-61 pubmed publisher
    ..the association between lymphoma prognosis and aberrant methylation of inhibitor of DNA binding factor 4 (ID4) and tight junction protein 1 (ZO-1) genes in samples isolated from the bone marrow and paraffin-embedded lymphoma ..
  69. Edenberg H, Koller D, Xuei X, Wetherill L, McClintick J, Almasy L, et al. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res. 2010;34:840-52 pubmed publisher
    ..SNPs nominated as candidates in earlier GWAS studies replicated in ours, including CPE, DNASE2B, SLC10A2, ARL6IP5, ID4, GATA4, SYNE1, and ADCY3...
  70. Zhao Y, Bo J, Dou L, Jing Y, Wang S, Wang Q, et al. [Preliminary study on difference of Id4 gene methylation in various types of myelodysplastic syndromes]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009;17:618-20 pubmed
    The aim of this study was to investigate the difference of Id4 gene promoter methylation in patients with different subtypes of myelodysplastic syndromes (MDS)...
  71. Rahme G, Israel M. Id4 suppresses MMP2-mediated invasion of glioblastoma-derived cells by direct inactivation of Twist1 function. Oncogene. 2015;34:53-62 pubmed publisher
    ..b>Id4 is expressed in GBM at more variable levels than these other family members and we sought to determine its role in ..
  72. Hafez M, Al Shabanah O, Al Rejaie S, Al Harbi N, Hassan Z, Alsheikh A, et al. Increased hypermethylation of glutathione S-transferase P1, DNA-binding protein inhibitor, death associated protein kinase and paired box protein-5 genes in triple-negative breast cancer Saudi females. Asian Pac J Cancer Prev. 2015;16:541-9 pubmed
    ..5 (PAX5), death associated protein kinase (DAPK), twist-related protein (TWIST), DNA-binding protein inhibitor (ID4), High In Normal-1 (HIN-1), cyclin-dependent kinase inhibitor 2A (p16), cyclin D2 and retinoic acid receptor-β (..
  73. Junankar S, Baker L, Roden D, Nair R, Elsworth B, Gallego Ortega D, et al. ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype. Nat Commun. 2015;6:6548 pubmed publisher
    ..In this study, we show that inhibitor of differentiation 4 (ID4) is a key regulator of mammary stem cell self-renewal and marks a subset of BLBC with a putative ..
  74. Rigolet M, Rich T, Gross Morand M, Molina Gomes D, Viegas Pequignot E, Junien C. cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. DNA Res. 1998;5:309-13 pubmed
    A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported...
  75. Branham M, Campoy E, Laurito S, Branham R, Urrutia G, Orozco J, et al. Epigenetic regulation of ID4 in the determination of the BRCAness phenotype in breast cancer. Breast Cancer Res Treat. 2016;155:13-23 pubmed publisher
    ..predictors for BRCAness tumors were the methylations of MLH1 and PAX5 plus the unmethylations of CCND2 and ID4. We determined that ID4 unmethylation correlated with the expression levels of both its mRNA and protein...
  76. Mohan R, Morgan B, Anumanthan G, Sharma A, Chaurasia S, Rieger F. Characterization of Inhibitor of differentiation (Id) proteins in human cornea. Exp Eye Res. 2016;146:145-53 pubmed publisher
    ..HCF expressed all known mammalian Id genes (Id1-Id4). In addition, Id1 and Id2 are selectively expressed in HCF...
  77. Nguyen T, Shively J. Induction of Lumen Formation in a Three-dimensional Model of Mammary Morphogenesis by Transcriptional Regulator ID4: ROLE OF CaMK2D IN THE EPIGENETIC REGULATION OF ID4 GENE EXPRESSION. J Biol Chem. 2016;291:16766-76 pubmed publisher
    ..b>ID4, a transcriptional regulator lacking a DNA binding domain, is highly up-regulated in CEACAM1-transfected MCF7 cells,..
  78. Zhang J, Zhou W, Liu Y, Li N. Integrated analysis of DNA methylation and RNA?sequencing data in Down syndrome. Mol Med Rep. 2016;14:4309-4314 pubmed publisher
    ..Functional enrichment analysis indicated that inhibitor of DNA binding 4 (ID4) was involved in neuronal differentiation and transcriptional suppression...
  79. Zhao Y, Wang Q, Dou L, Bo J, Li H, Jing Y, et al. [Methylation of Id4 gene promoter in acute leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007;15:1156-60 pubmed
    This study was purpose to investigate the difference of Id4 gene promoter methylation between healthy individuals and acute leukemia patients...
  80. Pruszko M, Milano E, Forcato M, Donzelli S, Ganci F, Di Agostino S, et al. The mutant p53-ID4 complex controls VEGFA isoforms by recruiting lncRNA MALAT1. EMBO Rep. 2017;18:1331-1351 pubmed publisher
    ..In this study, we demonstrate that oncogenic splicing factor SRSF1 bridges MALAT1 to mutant p53 and ID4 proteins in breast cancer cells...
  81. Zhang Y, Zhang L, Liu X, Zhao F, Ge C, Chen T, et al. Id4 promotes cell proliferation in hepatocellular carcinoma. Chin J Cancer. 2017;36:19 pubmed publisher
    ..As a member of the inhibitor of differentiation (Id) family, Id4 has been reported to function in many cancer types, but relatively little is known about its role in HCC...
  82. Fernani D, Prado M, da Silva T, Massetti T, de Abreu L, Magalhães F, et al. Evaluation of speed-accuracy trade-off in a computer task in individuals with cerebral palsy: a cross-sectional study. BMC Neurol. 2017;17:143 pubmed publisher
    ..CP and TD groups, speed-accuracy trade-off was found when using different indices of difficulty (ID2 and ID4)...
  83. Wang X, Kang H, Cen J, Li Y, Wang L, Yu L. [Methylation status of id4 gene promoter in patients with chronic myeloid leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18:1402-4 pubmed
    This study was purposed to investigate the methylation status of id4 gene promoter in patients with chronic myeloid leukemia (CML) and explore the relationship between methylation of the id4 gene and progress of CML...