ID4

Summary

Gene Symbol: ID4
Description: inhibitor of DNA binding 4, HLH protein
Alias: IDB4, bHLHb27, DNA-binding protein inhibitor ID-4, class B basic helix-loop-helix protein 27, inhibitor of DNA binding 4, dominant negative helix-loop-helix protein, inhibitor of differentiation 4
Species: human
Products:     ID4

Top Publications

  1. Beger C, Pierce L, Kruger M, Marcusson E, Robbins J, Welcsh P, et al. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. Proc Natl Acad Sci U S A. 2001;98:130-5 pubmed
    ..The cellular target gene of one ribozyme was identified to be the dominant negative transcriptional regulator Id4. Modulation of Id4 expression resulted in inversely regulated expression of BRCA1...
  2. Shan L, Yu M, Qiu C, Snyderwine E. Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. Am J Pathol. 2003;163:2495-502 pubmed
    b>Id4 belongs to a family of helix-loop-helix (HLH) proteins that impact cellular growth and differentiation via regulation of basic HLH transcription factors. Herein the rat Id4 gene was cloned (GenBank Accession No. AF468681)...
  3. Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu Y, et al. Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Nat Genet. 2005;37:265-74 pubmed
    ..We also identified Idb4 as a putative tumor-suppressor gene that is methylated in most mouse and human leukemias but in only a minority of ..
  4. Russell L, Akasaka T, Majid A, Sugimoto K, Loraine Karran E, Nagel I, et al. t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood. 2008;111:387-91 pubmed
    ..Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4...
  5. Chen S, Claus R, Lucas D, Yu L, Qian J, Ruppert A, et al. Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL. Blood. 2011;117:862-71 pubmed publisher
    Inhibitor of DNA binding protein 4 (ID4) is a member of the dominant-negative basic helix-loop-helix transcription factor family that lacks DNA binding activity and has tumor suppressor function...
  6. Fontemaggi G, Dell Orso S, Trisciuoglio D, Shay T, Melucci E, Fazi F, et al. The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. Nat Struct Mol Biol. 2009;16:1086-93 pubmed publisher
    b>ID4 (inhibitor of DNA binding 4) is a member of a family of proteins that function as dominant-negative regulators of basic helix-loop-helix transcription factors...
  7. Uhm K, Lee E, Lee Y, Park J, Kim S, Kim B, et al. Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia. J Korean Med Sci. 2009;24:493-7 pubmed publisher
    ..we identified the methylation status on one part of 5'CpG rich region of 8 genes, DAB2IP, DLC-1, H-cadherin, ID4, Integrin alpha4, RUNX3, SFRP1, and SHP1 in bone marrows from acute myeloid leukemia (AML) and chronic myeloid ..
  8. Jeon H, Jin X, Lee J, Oh S, Sohn Y, Park H, et al. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev. 2008;22:2028-33 pubmed publisher
    ..Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM...
  9. Wen Y, Ho A, Patil S, Akram M, Catalano J, Eaton A, et al. Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation. Breast Cancer Res Treat. 2012;135:93-102 pubmed publisher
    ..b>Id4, a helix-loop-helix DNA binding factor, blocks BRCA1 gene transcription in vitro and could downregulate BRCA1 in ..
  10. Lasorella A, Benezra R, Iavarone A. The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer. 2014;14:77-91 pubmed publisher
    ..The ability of ID proteins to function as central 'hubs' for the coordination of multiple cancer hallmarks has established these transcriptional regulators as therapeutic targets and biomarkers in specific types of human tumours. ..

Detail Information

Publications62

  1. Beger C, Pierce L, Kruger M, Marcusson E, Robbins J, Welcsh P, et al. Identification of Id4 as a regulator of BRCA1 expression by using a ribozyme-library-based inverse genomics approach. Proc Natl Acad Sci U S A. 2001;98:130-5 pubmed
    ..The cellular target gene of one ribozyme was identified to be the dominant negative transcriptional regulator Id4. Modulation of Id4 expression resulted in inversely regulated expression of BRCA1...
  2. Shan L, Yu M, Qiu C, Snyderwine E. Id4 regulates mammary epithelial cell growth and differentiation and is overexpressed in rat mammary gland carcinomas. Am J Pathol. 2003;163:2495-502 pubmed
    b>Id4 belongs to a family of helix-loop-helix (HLH) proteins that impact cellular growth and differentiation via regulation of basic HLH transcription factors. Herein the rat Id4 gene was cloned (GenBank Accession No. AF468681)...
  3. Yu L, Liu C, Vandeusen J, Becknell B, Dai Z, Wu Y, et al. Global assessment of promoter methylation in a mouse model of cancer identifies ID4 as a putative tumor-suppressor gene in human leukemia. Nat Genet. 2005;37:265-74 pubmed
    ..We also identified Idb4 as a putative tumor-suppressor gene that is methylated in most mouse and human leukemias but in only a minority of ..
  4. Russell L, Akasaka T, Majid A, Sugimoto K, Loraine Karran E, Nagel I, et al. t(6;14)(p22;q32): a new recurrent IGH@ translocation involving ID4 in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Blood. 2008;111:387-91 pubmed
    ..Fluorescence in situ hybridization and long-distance inverse polymerase chain reaction (PCR) identified ID4 as the partner gene. Breakpoints were scattered over a 19kb region centromeric of ID4...
  5. Chen S, Claus R, Lucas D, Yu L, Qian J, Ruppert A, et al. Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL. Blood. 2011;117:862-71 pubmed publisher
    Inhibitor of DNA binding protein 4 (ID4) is a member of the dominant-negative basic helix-loop-helix transcription factor family that lacks DNA binding activity and has tumor suppressor function...
  6. Fontemaggi G, Dell Orso S, Trisciuoglio D, Shay T, Melucci E, Fazi F, et al. The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis. Nat Struct Mol Biol. 2009;16:1086-93 pubmed publisher
    b>ID4 (inhibitor of DNA binding 4) is a member of a family of proteins that function as dominant-negative regulators of basic helix-loop-helix transcription factors...
  7. Uhm K, Lee E, Lee Y, Park J, Kim S, Kim B, et al. Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia. J Korean Med Sci. 2009;24:493-7 pubmed publisher
    ..we identified the methylation status on one part of 5'CpG rich region of 8 genes, DAB2IP, DLC-1, H-cadherin, ID4, Integrin alpha4, RUNX3, SFRP1, and SHP1 in bone marrows from acute myeloid leukemia (AML) and chronic myeloid ..
  8. Jeon H, Jin X, Lee J, Oh S, Sohn Y, Park H, et al. Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev. 2008;22:2028-33 pubmed publisher
    ..Here, we report a pathogenetic role of the developmental regulator Id4 (inhibitor of differentiation 4) in GBM...
  9. Wen Y, Ho A, Patil S, Akram M, Catalano J, Eaton A, et al. Id4 protein is highly expressed in triple-negative breast carcinomas: possible implications for BRCA1 downregulation. Breast Cancer Res Treat. 2012;135:93-102 pubmed publisher
    ..b>Id4, a helix-loop-helix DNA binding factor, blocks BRCA1 gene transcription in vitro and could downregulate BRCA1 in ..
  10. Lasorella A, Benezra R, Iavarone A. The ID proteins: master regulators of cancer stem cells and tumour aggressiveness. Nat Rev Cancer. 2014;14:77-91 pubmed publisher
    ..The ability of ID proteins to function as central 'hubs' for the coordination of multiple cancer hallmarks has established these transcriptional regulators as therapeutic targets and biomarkers in specific types of human tumours. ..
  11. Divito K, Simbulan Rosenthal C, Chen Y, Trabosh V, Rosenthal D. Id2, Id3 and Id4 overcome a Smad7-mediated block in tumorigenesis, generating TGF-β-independent melanoma. Carcinogenesis. 2014;35:951-8 pubmed publisher
    ..We found that endogenous Id2, Id3 and Id4 expression was elevated in 1205Lu versus 1205Lu cells constitutively expressing Smad7, indicating Ids may play a ..
  12. Knowell A, Patel D, Morton D, Sharma P, Glymph S, Chaudhary J. Id4 dependent acetylation restores mutant-p53 transcriptional activity. Mol Cancer. 2013;12:161 pubmed publisher
    ..Here we demonstrate that Id4, an HLH transcriptional regulator and a tumor suppressor, can restore the mutant p53 transcriptional activity in ..
  13. Gómez del Pulgar T, Valdes Mora F, Bandres E, Pérez Palacios R, Espina C, Cejas P, et al. Cdc42 is highly expressed in colorectal adenocarcinoma and downregulates ID4 through an epigenetic mechanism. Int J Oncol. 2008;33:185-93 pubmed
    ..Cdc42 levels through siRNA revealed that Cdc42 overexpression down-regulated the potential tumour suppressor gene ID4. Results were validated by quantitative RT-PCR and the methylation status of the specific promoter, analyzed...
  14. Sullivan J, Havrda M, Kettenbach A, Paolella B, Zhang Z, Gerber S, et al. Phosphorylation Regulates Id2 Degradation and Mediates the Proliferation of Neural Precursor Cells. Stem Cells. 2016;34:1321-31 pubmed publisher
    Inhibitor of DNA binding proteins (Id1-Id4) function to inhibit differentiation and promote proliferation of many different cell types...
  15. Boareto M, Iber D, Taylor V. Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation. Development. 2017;144:3465-3474 pubmed publisher
    ..During brain development, Notch signaling dominates and directly regulates Id4 expression, preventing other ID factors from inducing NSC quiescence...
  16. Agrimson K, Oatley M, Mitchell D, Oatley J, Griswold M, Hogarth C. Retinoic acid deficiency leads to an increase in spermatogonial stem number in the neonatal mouse testis, but excess retinoic acid results in no change. Dev Biol. 2017;: pubmed publisher
    ..Whole mount immunofluorescence and flow cytometric analysis using the Id4-eGfp transgenic reporter mouse line revealed an enrichment for ID4-EGFP+ cells within the testis following ..
  17. Peddada S, Yasui D, LaSalle J. Inhibitors of differentiation (ID1, ID2, ID3 and ID4) genes are neuronal targets of MeCP2 that are elevated in Rett syndrome. Hum Mol Genet. 2006;15:2003-14 pubmed
    ..all four known members of the inhibitors of differentiation or inhibitors of DNA-binding (ID1, ID2, ID3 and ID4) subfamily of helix-loop-helix genes as novel neuronal targets of MeCP2...
  18. Zhao Y, Wang Q, Li H, Bo J, Dou L, Jing Y, et al. [Significance of id4 promoter methylation in monitoring AML patients with completely remission]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008;16:476-8 pubmed
    The study was purposed to investigate the significance of id4 gene promoter methylation in monitoring AML patients with complete remission (CR)...
  19. Loveys D, Streiff M, Kato G. E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein. Nucleic Acids Res. 1996;24:2813-20 pubmed
    ..Four murine cDNAs were identified in the screen, all of which encode helix-loop-helix proteins: E12, E47, ALF1 and Id4. Co-immunoprecipitation assays confirm that Id3 interacts with E12, E47 and two alternative splice products of ALF1 ..
  20. Rigolet M, Rich T, Gross Morand M, Molina Gomes D, Viegas Pequignot E, Junien C. cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. DNA Res. 1998;5:309-13 pubmed
    A cDNA e encoding the human Id4 protein has been isolated from an astrocytoma library. The predicted protein product shares 98% identity with the mouse Id4 protein and is markedly different from that already reported...
  21. Galardi S, Savino M, Scagnoli F, Pellegatta S, Pisati F, Zambelli F, et al. Resetting cancer stem cell regulatory nodes upon MYC inhibition. EMBO Rep. 2016;17:1872-1889 pubmed
    ..identity such as OLIG2, POU3F2, SOX2, upregulation of effectors of tumour suppression and differentiation such as ID4, MIAT, PTEN, and modulation of the expression of microRNAs that target molecules implicated in glioblastoma growth ..
  22. Nguyen T, Shively J. Induction of Lumen Formation in a Three-dimensional Model of Mammary Morphogenesis by Transcriptional Regulator ID4: ROLE OF CaMK2D IN THE EPIGENETIC REGULATION OF ID4 GENE EXPRESSION. J Biol Chem. 2016;291:16766-76 pubmed publisher
    ..b>ID4, a transcriptional regulator lacking a DNA binding domain, is highly up-regulated in CEACAM1-transfected MCF7 cells,..
  23. Mohan R, Morgan B, Anumanthan G, Sharma A, Chaurasia S, Rieger F. Characterization of Inhibitor of differentiation (Id) proteins in human cornea. Exp Eye Res. 2016;146:145-53 pubmed publisher
    ..HCF expressed all known mammalian Id genes (Id1-Id4). In addition, Id1 and Id2 are selectively expressed in HCF...
  24. Zhao Y, Bo J, Dou L, Jing Y, Wang S, Wang Q, et al. [Preliminary study on difference of Id4 gene methylation in various types of myelodysplastic syndromes]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009;17:618-20 pubmed
    The aim of this study was to investigate the difference of Id4 gene promoter methylation in patients with different subtypes of myelodysplastic syndromes (MDS)...
  25. Edenberg H, Koller D, Xuei X, Wetherill L, McClintick J, Almasy L, et al. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res. 2010;34:840-52 pubmed publisher
    ..SNPs nominated as candidates in earlier GWAS studies replicated in ours, including CPE, DNASE2B, SLC10A2, ARL6IP5, ID4, GATA4, SYNE1, and ADCY3...
  26. Saied M, Marzec J, Khalid S, Smith P, Down T, Rakyan V, et al. Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats. PLoS ONE. 2012;7:e33213 pubmed publisher
    ..MeDIP-seq data were validated using bisulfite pyrosequencing and the Infinium array. ..
  27. Albertsen H, Chettier R, Farrington P, Ward K. Genome-wide association study link novel loci to endometriosis. PLoS ONE. 2013;8:e58257 pubmed publisher
    ..51×10(-7) we identify two additional loci in our meta-analysis that associate with endometriosis:, RNF144B-ID4 on 6p22.3 (rs6907340; P = 2.19×10(-7), OR = 1.20, Cl = 1.12-1.28), and HNRNPA3P1-LOC100130539 on 10q11...
  28. Zhao Y, Wang Q, Dou L, Bo J, Li H, Jing Y, et al. [Methylation of Id4 gene promoter in acute leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007;15:1156-60 pubmed
    This study was purpose to investigate the difference of Id4 gene promoter methylation between healthy individuals and acute leukemia patients...
  29. Wang X, Kang H, Cen J, Li Y, Wang L, Yu L. [Methylation status of id4 gene promoter in patients with chronic myeloid leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18:1402-4 pubmed
    This study was purposed to investigate the methylation status of id4 gene promoter in patients with chronic myeloid leukemia (CML) and explore the relationship between methylation of the id4 gene and progress of CML...
  30. Fernani D, Prado M, da Silva T, Massetti T, de Abreu L, Magalhães F, et al. Evaluation of speed-accuracy trade-off in a computer task in individuals with cerebral palsy: a cross-sectional study. BMC Neurol. 2017;17:143 pubmed publisher
    ..CP and TD groups, speed-accuracy trade-off was found when using different indices of difficulty (ID2 and ID4)...