ID2

Summary

Gene Symbol: ID2
Description: inhibitor of DNA binding 2
Alias: GIG8, ID2A, ID2H, bHLHb26, DNA-binding protein inhibitor ID-2, DNA-binding protein inhibitor ID2, cell growth-inhibiting gene 8, class B basic helix-loop-helix protein 26, helix-loop-helix protein ID2, inhibitor of DNA binding 2, HLH protein, inhibitor of DNA binding 2, dominant negative helix-loop-helix protein, inhibitor of differentiation 2
Species: human
Products:     ID2

Top Publications

  1. Wang S, Sdrulla A, Johnson J, Yokota Y, Barres B. A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte development. Neuron. 2001;29:603-14 pubmed
    ..We show here that oligodendrocyte lineage cells express the helix-loop-helix proteins Mash1 and Id2. Although Mash1 has been found to regulate neuronal development, we found that in the absence of Mash1 ..
  2. Yokota Y, Mansouri A, Mori S, Sugawara S, Adachi S, Nishikawa S, et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature. 1999;397:702-6 pubmed
    ..Here we show that Id2 is indispensable for normal development of mice. Id2-/- mice lack lymph nodes and Peyer's patches...
  3. Jögi A, Persson P, Grynfeld A, Påhlman S, Axelson H. Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation. J Biol Chem. 2002;277:9118-26 pubmed
    ..We found that the three Id proteins expressed in neuroblastoma cells (Id1, Id2, and Id3) were down-regulated during induced differentiation, indicating that Id proteins help keep the tumor cells ..
  4. Itahana Y, Singh J, Sumida T, Coppe J, Parrinello S, Bennington J, et al. Role of Id-2 in the maintenance of a differentiated and noninvasive phenotype in breast cancer cells. Cancer Res. 2003;63:7098-105 pubmed
  5. Liu J, Shi W, Warburton D. A cysteine residue in the helix-loop-helix domain of Id2 is critical for homodimerization and function. Biochem Biophys Res Commun. 2000;273:1042-7 pubmed
    ..In this study, we compared the expression of Id2 mRNA in proliferating (fetal) and nonproliferating (adult) alveolar epithelial cells (AECs)...
  6. Damdinsuren B, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Yamamoto T, et al. Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Int J Oncol. 2005;26:319-27 pubmed
    ..We examined the immunohistochemical expression of Id1, Id2 and Id3 proteins in 54 surgically resected HCCs with surrounding HCV or HBV-related chronic hepatitis (n=30) and ..
  7. Yates P, Atherton G, Deed R, Norton J, Sharrocks A. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 1999;18:968-76 pubmed
    ..Therefore, our results demonstrate a novel facet of Id function in the coordination of mitogenic signalling and cell cycle entry. ..
  8. Li X, Luo Y, Starremans P, McNamara C, Pei Y, Zhou J. Polycystin-1 and polycystin-2 regulate the cell cycle through the helix-loop-helix inhibitor Id2. Nat Cell Biol. 2005;7:1202-12 pubmed
    ..Here, we show that the ADPKD protein polycystin-2 (PC2) regulates the cell cycle through direct interaction with Id2, a member of the helix-loop-helix (HLH) protein family that is known to regulate cell proliferation and ..
  9. Rothschild G, Zhao X, Iavarone A, Lasorella A. E Proteins and Id2 converge on p57Kip2 to regulate cell cycle in neural cells. Mol Cell Biol. 2006;26:4351-61 pubmed
    ..Here we show that progression into S phase of human neuroblastoma cells is prevented by E proteins and promoted by Id2. Cyclin-dependent kinase inhibitors (CKI) have been identified as key effectors of cell cycle arrest in ..

More Information

Publications85

  1. Biggs J, Murphy E, Israel M. A human Id-like helix-loop-helix protein expressed during early development. Proc Natl Acad Sci U S A. 1992;89:1512-6 pubmed
    ..These findings suggest that Id-2 is an inhibitor of tissue-specific gene expression, although its distinctive pattern of expression during development suggests a role different from that of Id. ..
  2. Tsunedomi R, Iizuka N, Tamesa T, Sakamoto K, Hamaguchi T, Somura H, et al. Decreased ID2 promotes metastatic potentials of hepatocellular carcinoma by altering secretion of vascular endothelial growth factor. Clin Cancer Res. 2008;14:1025-31 pubmed publisher
    We aimed to explore the molecular and biological functions of Inhibitor of DNA binding/differentiation 2 (ID2), which was found to be responsible for portal vein invasion of hepatocellular carcinoma (HCC)...
  3. Iavarone A, Garg P, Lasorella A, Hsu J, Israel M. The helix-loop-helix protein Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev. 1994;8:1270-84 pubmed
  4. Lasorella A, Stegmuller J, Guardavaccaro D, Liu G, Carro M, Rothschild G, et al. Degradation of Id2 by the anaphase-promoting complex couples cell cycle exit and axonal growth. Nature. 2006;442:471-4 pubmed
    In the developing nervous system, Id2 (inhibitor of DNA binding 2, also known as inhibitor of differentiation 2) enhances cell proliferation, promotes tumour progression and inhibits the activity of neurogenic basic helix-loop-helix (bHLH)..
  5. Renne C, Martin Subero J, Eickernjäger M, Hansmann M, Kuppers R, Siebert R, et al. Aberrant expression of ID2, a suppressor of B-cell-specific gene expression, in Hodgkin's lymphoma. Am J Pathol. 2006;169:655-64 pubmed
    ..We show here that ID2, which can inactivate E2A and perhaps PAX5, is not detectable in normal B cells but is strongly and uniformly ..
  6. Buitenhuis M, van Deutekom H, Verhagen L, Castor A, Jacobsen S, Lammers J, et al. Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. Blood. 2005;105:4272-81 pubmed
    ..In this study, we have investigated the role of Id1 and Id2 in the regulation of granulopoiesis...
  7. Gray M, Dallas N, Van Buren G, Xia L, Yang A, Somcio R, et al. Therapeutic targeting of Id2 reduces growth of human colorectal carcinoma in the murine liver. Oncogene. 2008;27:7192-200 pubmed publisher
    During development inhibitor of DNA-bind-2 (Id2) regulates proliferation and differentiation. Id2 expression has been detected in cancer cells, yet its cellular function and validity as a therapeutic target remains largely unknown...
  8. Fukuma M, Okita H, Hata J, Umezawa A. Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma. Oncogene. 2003;22:1-9 pubmed
    ..not in other tumor cell lines using the gene array technique, and found significantly enhanced expression of the Id2 gene. High levels of Id2 transcripts were detected in Ewing sarcoma cell lines and tumor tissues...
  9. Nishimori H, Sasaki Y, Yoshida K, Irifune H, Zembutsu H, Tanaka T, et al. The Id2 gene is a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors. Oncogene. 2002;21:8302-9 pubmed
    We report here that the Id2 (inhibitor of DNA binding 2) gene is a novel target of transcriptional activation by EWS-FLI1 and EWS-ERG, two fusion proteins that characterize Ewing family tumors (EFTs)...
  10. Liu C, Ding B, Wang H, Lengyel P. The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins. Mol Cell Biol. 2002;22:2893-905 pubmed
    ..least in part, by overcoming the inhibition of the activities of the MyoD and E47 proteins by the Id proteins: Id1, Id2, and Id3...
  11. Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, et al. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J Biol Chem. 1994;269:2139-45 pubmed
    ..SVts8 cells may acquire some function redundant to Id proteins. HT1080 fibrosarcoma cells expressed the Id-1H gene but not the Id-2H gene, suggesting these Id genes may subserve redundant functions. ..
  12. Hara E, Hall M, Peters G. Cdk2-dependent phosphorylation of Id2 modulates activity of E2A-related transcription factors. EMBO J. 1997;16:332-42 pubmed
    The helix-loop-helix (HLH) protein Id2 is thought to affect the balance between cell growth and differentiation by negatively regulating the function of basic-helix-loop-helix (bHLH) transcription factors...
  13. Langlands K, Yin X, Anand G, Prochownik E. Differential interactions of Id proteins with basic-helix-loop-helix transcription factors. J Biol Chem. 1997;272:19785-93 pubmed
    Dimerization of three Id proteins (Id1, Id2, and Id3) with the four class A E proteins (E12, E47, E2-2, and HEB) and two groups of class B proteins, the myogenic regulatory factors (MRFs: MyoD, myogenin, Myf-5 and MRF4/Myf-6), and the ..
  14. Coma S, Amin D, Shimizu A, Lasorella A, Iavarone A, Klagsbrun M. Id2 promotes tumor cell migration and invasion through transcriptional repression of semaphorin 3F. Cancer Res. 2010;70:3823-32 pubmed publisher
    ..It was found that Semaphorin 3F (SEMA3F), a potent inhibitor of metastasis, was repressed by Id2. High metastatic human tumor cell lines had relatively high amounts of Id2 and low SEMA3F levels compared with ..
  15. Lasorella A, Iavarone A, Israel M. Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins. Mol Cell Biol. 1996;16:2570-8 pubmed
    Cells which are highly proliferative typically lack expression of differentiated, lineage-specific characteristics. Id2, a member of the helix-loop-helix (HLH) protein family known to inhibit cell differentiation, binds to the ..
  16. Lasorella A, Iavarone A. The protein ENH is a cytoplasmic sequestration factor for Id2 in normal and tumor cells from the nervous system. Proc Natl Acad Sci U S A. 2006;103:4976-81 pubmed
    b>Id2 is a natural inhibitor of the basic helix-loop-helix transcription factors and the retinoblastoma tumor suppressor protein...
  17. Baghdoyan S, Lamartine J, Castel D, Pitaval A, Roupioz Y, Franco N, et al. Id2 reverses cell cycle arrest induced by {gamma}-irradiation in human HaCaT keratinocytes. J Biol Chem. 2005;280:15836-41 pubmed
    b>Id2 plays a key role in epithelial cells, regulating differentiation, the cell cycle, and proliferation...
  18. Liu Y, Burleigh D, Durning M, Hudson L, Chiu I, Golos T. Id2 is a primary partner for the E2-2 basic helix-loop-helix transcription factor in the human placenta. Mol Cell Endocrinol. 2004;222:83-91 pubmed
    We screened a term placental cDNA library by the yeast two-hybrid approach with Id2, a negative regulator of basic helix-loop-helix (bHLH) factors. Of the clones obtained, approximately one-third were the E2-2 bHLH transcription factor...
  19. Coppe J, Itahana Y, Moore D, Bennington J, Desprez P. Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression. Clin Cancer Res. 2004;10:2044-51 pubmed
    ..We propose that both Id-1 and Id-2 proteins control prostate cancer cell phenotypes and could serve as molecular markers of aggressive human prostate cancer. ..
  20. Fajerman I, Schwartz A, Ciechanover A. Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination. Biochem Biophys Res Commun. 2004;314:505-12 pubmed
    ..Here, we demonstrate that the inhibitor of differentiation (or inhibitor of DNA binding) 2, Id2, that downregulates gene expression in undifferentiated and self-renewing cells, is degraded by the UPS following ..
  21. Hacker C, Kirsch R, Ju X, Hieronymus T, Gust T, Kuhl C, et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol. 2003;4:380-6 pubmed
    ..Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo...
  22. Lasorella A, Noseda M, Beyna M, Yokota Y, Iavarone A. Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins. Nature. 2000;407:592-8 pubmed
    In mammalian cells, Id proteins coordinate proliferation and differentiation. Id2 is a dominant-negative antagonist of basic helix-loop-helix transcription factors and proteins of the retinoblastoma (Rb) family...
  23. Roberts E, Deed R, Inoue T, Norton J, Sharrocks A. Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding. Mol Cell Biol. 2001;21:524-33 pubmed
    ..Our results therefore demonstrate a novel facet of Id function in regulating cellular differentiation by functionally antagonizing the action of members of the Pax transcription factor family. ..
  24. Nigten J, Breems de Ridder M, Erpelinck Verschueren C, Nikoloski G, van der Reijden B, van Wageningen S, et al. ID1 and ID2 are retinoic acid responsive genes and induce a G0/G1 accumulation in acute promyelocytic leukemia cells. Leukemia. 2005;19:799-805 pubmed
    ..Here we report the identification of two ATRA responsive genes in APL cells, ID1 and ID2. These proteins act as antagonists of basic helix-loop-helix (bHLH) transcription factors...
  25. Lasorella A, Boldrini R, Dominici C, Donfrancesco A, Yokota Y, Inserra A, et al. Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma. Cancer Res. 2002;62:301-6 pubmed
    Perturbation of the function of the retinoblastoma (Rb) protein is found in most human tumors. Id2 is a natural target of the Rb protein that is recruited by Myc oncoproteins to bypass the tumor suppressor function of Rb...
  26. Moreno M, Fernández V, Monllau J, Borrell V, Lerin C, de la Iglesia N. Transcriptional Profiling of Hypoxic Neural Stem Cells Identifies Calcineurin-NFATc4 Signaling as a Major Regulator of Neural Stem Cell Biology. Stem Cell Reports. 2015;5:157-65 pubmed publisher
    ..that the calcineurin-NFATc4 signaling axis acts as a major regulator of NSC self-renewal and proliferation in vitro and in vivo by promoting the expression of TFs, including Id2, that contribute to the maintenance of the NSC state.
  27. Wang W, Liu Y, Hao J, Zheng S, Wen Y, Xiao X, et al. Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis. Gene. 2016;591:43-47 pubmed publisher
    ..OA cartilage detected 8 common differently expressed genes, including COL5A1, OGN, ANGPTL4, CRIP1, NFIL3, METRNL, ID2 and STEAP1...
  28. Tsai T, JOHNSON J, White Y, John J. The molecular characterization of porcine egg precursor cells. Oncotarget. 2017;8:63484-63505 pubmed publisher
    ..Moreover, porcine EPCs expressed self-renewal and proliferation markers including Myc, Esrrb, Id2, Klf4, Klf5, Stat3, Fgfr1, Fgfr2 and Il6st...
  29. Rollin J, Blechet C, Regina S, Tenenhaus A, Guyetant S, Gidrol X. The intracellular localization of ID2 expression has a predictive value in non small cell lung cancer. PLoS ONE. 2009;4:e4158 pubmed publisher
    b>ID2 is a member of a subclass of transcription regulators belonging to the general bHLH (basic-helix-loop-helix) family of transcription factors...
  30. Wang H, Qian L, Zhao Y, Mengarelli J, Adrianto I, Montgomery C, et al. Downregulation of E Protein Activity Augments an ILC2 Differentiation Program in the Thymus. J Immunol. 2017;198:3149-3156 pubmed publisher
    ..b>Id2, an inhibitor of E protein transcription factors, is indispensable for ILC differentiation...
  31. Ripamonti U, Klar R, Parak R, Dickens C, Dix Peek T, Duarte R. Tissue segregation restores the induction of bone formation by the mammalian transforming growth factor-β(3) in calvarial defects of the non-human primate Papio ursinus. Biomaterials. 2016;86:21-32 pubmed publisher
    ..OP-1), osteocalcin (OC), bone morphogenetic protein-2 (BMP-2), RUNX-2 and inhibitor of DNA binding-2 and -3 (ID2,ID3) and up regulation of TGF-β3, a molecular signalling pathway inhibiting the induction of membranous bone ..
  32. Khaliq M, Choi T, So J, Shin D. Id2a is required for hepatic outgrowth during liver development in zebrafish. Mech Dev. 2015;138 Pt 3:399-414 pubmed publisher
    ..However, a functional role of Id2a in liver development has not yet been reported...
  33. Zhang X, Lv C, Du B, Ma X, Guan J, Gao S, et al. Upregulation of ID2 antagonizes arsenic trioxide-induced antitumor effects in cancer cells. Tumori. 2014;100:352-7 pubmed publisher
    ..Although many signaling pathways are involved in its antitumor mechanism, a detailed investigation of the transforming growth factor beta-bone morphogenetic protein signaling pathway has not been performed...
  34. Ward S, Fernando S, Hou T, Duffield G. The transcriptional repressor ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression. J Biol Chem. 2010;285:38987-9000 pubmed publisher
    b>ID2 is a rhythmically expressed HLH transcriptional repressor. Deletion of Id2 in mice results in circadian phenotypes, highlighted by disrupted locomotor activity rhythms and an enhanced photoentrainment response...
  35. Yang J, Davies R, Southwood M, Long L, Yang X, Sobolewski A, et al. Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension. Circ Res. 2008;102:1212-21 pubmed publisher
    ..Mutant cells demonstrated a marked deficiency in BMP4-stimulated Id1 and Id2 gene and protein expression compared with control cells...
  36. Svoboda M, Meshcheryakova A, Heinze G, Jaritz M, Pils D, Castillo Tong D, et al. AID/APOBEC-network reconstruction identifies pathways associated with survival in ovarian cancer. BMC Genomics. 2016;17:643 pubmed publisher
    ..Furthermore, several of the profiling-derived variables such as ID3, PTPRC/CD45, AID, APOBEC3G, and ID2 exceed the prognostic impact of some clinicopathological variables...
  37. Ma J, Zeng S, Zhang Y, Deng G, Qu Y, Guo C, et al. BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling. Mol Carcinog. 2017;56:2279-2289 pubmed publisher
    ..b>Id2 was directly upregulated by BMP4, resulting in the mediated expression of cell cycle regulatory protein of CDKN1B...
  38. Han W, Wu Z, Zhao Y, Meng Y, Si Y, Yang J, et al. FHL2 interacts with and acts as a functional repressor of Id2 in human neuroblastoma cells. Nucleic Acids Res. 2009;37:3996-4009 pubmed publisher
    b>Inhibitor of differentiation 2 (Id2) is a natural inhibitor of the basic helix-loop-helix transcription factors...
  39. Mowel W, McCright S, Kotzin J, Collet M, Uyar A, Chen X, et al. Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA. Immunity. 2017;47:435-449.e8 pubmed publisher
    Commitment to the innate lymphoid cell (ILC) lineage is determined by Id2, a transcriptional regulator that antagonizes T and B cell-specific gene expression programs...
  40. Sumida T, Ishikawa A, Nakano H, Yamada T, Mori Y, Desprez P. Targeting ID2 expression triggers a more differentiated phenotype and reduces aggressiveness in human salivary gland cancer cells. Genes Cells. 2016;21:915-20 pubmed publisher
    ..Here, we show that ID2 is also expressed in aggressive SGC cells...
  41. Ghisi M, Kats L, Masson F, Li J, Kratina T, Vidacs E, et al. Id2 and E Proteins Orchestrate the Initiation and Maintenance of MLL-Rearranged Acute Myeloid Leukemia. Cancer Cell. 2016;30:59-74 pubmed publisher
    ..We found that Id2 acts as a key regulator of leukemia stem cell (LSC) potential in MLL-rearranged acute myeloid leukemia (AML)...
  42. Mo S, Liu X, Hao X, Chen W, Zhang K, Cai J, et al. EYA4 functions as tumor suppressor gene and prognostic marker in pancreatic ductal adenocarcinoma through ?-catenin/ID2 pathway. Cancer Lett. 2016;380:403-12 pubmed publisher
    ..activity, EYA4 dephosphorylated ?-catenin at Ser675, blocked ?-catenin nuclear translocation and inhibited ID2 transactivation...
  43. Mori K, Nakamura H, Kurooka H, Miyachi H, Tamada K, Sugai M, et al. Id2 determines intestinal identity through repression of the foregut transcription factor, Irx5. Mol Cell Biol. 2018;: pubmed publisher
    ..Here, we report on the involvement of the helix-loop-helix inhibitor Id2 in establishing the specific characteristics of the intestinal epithelium...
  44. Siegel P, Shu W, Massague J. Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. J Biol Chem. 2003;278:35444-50 pubmed
    ..b>Id2 expression is often highest in proliferating epithelial cells and declines during differentiation...
  45. Sato Y, Kobayashi Y, Sasaki H, Toyama T, Kondo S, Kiriyama M, et al. Expression of Id2 mRNA in neuroblastoma and normal ganglion. Eur J Surg Oncol. 2003;29:284-7 pubmed
    Inhibitors of DNA binding 2 (Id2) has been reported to be overexpressed in neuroblastoma cell lines carrying extra copies of the N-myc gene...
  46. Scott C, Soen B, Martens L, Skrypek N, Saelens W, Taminau J, et al. The transcription factor Zeb2 regulates development of conventional and plasmacytoid DCs by repressing Id2. J Exp Med. 2016;213:897-911 pubmed publisher
    ..Several transcription factors (TFs) have been implicated in regulating the development of pDCs (E2-2 and Id2) and cDC1s (Irf8, Id2, and Batf3); however, those required for the early commitment of pre-cDCs toward the cDC2 ..
  47. Zhao T, Jia H, Zhang Z, Zhao X, Zou Y, Zhang W, et al. LncRNA H19 regulates ID2 expression through competitive binding to hsa-miR-19a/b in acute myelocytic leukemia. Mol Med Rep. 2017;16:3687-3693 pubmed publisher
    ..expression of hsa‑microRNA (miR)‑19a/b and decreased expression of inhibitor of DNA binding 2 (ID2) in AML cells...
  48. He R, Hou S, Liu C, Zhang A, Bai Q, Han M, et al. Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection. Nature. 2016;537:412-428 pubmed publisher
    ..Furthermore, we identified the Id2-E2A signalling axis as an important regulator of the generation of this subset...
  49. Seyerle A, Lin H, Gogarten S, Stilp A, Mendez Giraldez R, Soliman E, et al. Genome-wide association study of PR interval in Hispanics/Latinos identifies novel locus at ID2. Heart. 2017;: pubmed publisher
    ..However, they remain chronically understudied. We present the first genome-wide association study (GWAS) of PR in 14?756 participants of Hispanic/Latino ancestry from three studies...
  50. Male V, Brady H. Murine thymic NK cells: A case of identity. Eur J Immunol. 2017;47:797-799 pubmed publisher
    ..They provide a valuable insight into the distinctive identity of thymic NK cells with regard to Tbet, Nfil3, Id2, and Ets1...
  51. Shaw L, Belanger S, Omilusik K, Cho S, Scott Browne J, Nance J, et al. Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation. Nat Immunol. 2016;17:834-43 pubmed publisher
    ..Here, TH1 cells showed more robust Id2 expression than that of TFH cells, and depletion of Id2 via RNA-mediated interference increased the frequency of ..
  52. He S, Liu Y, Meng L, Sun H, Wang Y, Ji Y, et al. Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity. Nat Commun. 2017;8:2125 pubmed publisher
    ..Ezh2 activates Id3 while silencing Id2, Prdm1 and Eomes, promoting the expansion of memory precursor cells and their differentiation into functional ..
  53. Jensen K, Rother M, Brusletto B, Olstad O, Dalsbotten Aass H, van Zelm M, et al. Increased ID2 levels in adult precursor B cells as compared with children is associated with impaired Ig locus contraction and decreased bone marrow output. J Immunol. 2013;191:1210-9 pubmed publisher
    ..not in children, showed highly upregulated expression of the differentiation inhibitor, inhibitor of DNA binding 2 (ID2), in absence of changes in expression of the ID2-binding partner E2A...
  54. Gabrielli S, Sun M, Bell A, Zook E, de Pooter R, Zamai L, et al. Murine thymic NK cells are distinct from ILC1s and have unique transcription factor requirements. Eur J Immunol. 2017;47:800-805 pubmed publisher
    ..tNK cells resemble NK cells rather than ILC1 in their requirements for the E protein transcription factor inhibitor ID2. We provide further insight into the mechanisms governing tNK-cell development by showing that the transcription ..
  55. Moldes M, Boizard M, Liepvre X, Feve B, Dugail I, Pairault J. Functional antagonism between inhibitor of DNA binding (Id) and adipocyte determination and differentiation factor 1/sterol regulatory element-binding protein-1c (ADD1/SREBP-1c) trans-factors for the regulation of fatty acid synthase promoter in adip. Biochem J. 1999;344 Pt 3:873-80 pubmed
    ..Gel mobility-shift assays performed with in vitro-translated ADD1, Id2 or Id3 proteins and a fatty acid synthase (FAS) promoter oligonucleotide showed evidence for a marked inhibition of ..
  56. He J, Liu J, Liu F, Tan P, Lin T, Li X. Mutation screening of BMP4 and Id2 genes in Chinese patients with congenital ureteropelvic junction obstruction. Eur J Pediatr. 2012;171:451-6 pubmed publisher
    ..Evidence has shown that BMP4 and Id2 play crucial roles in nephrogenesis, alterations of which may cause ureteral developmental anomalies...
  57. Su F, Li B, Wang J, Xu X, Ren R, Li L, et al. Molecular regulation of vasculogenic mimicry in human uveal melanoma cells: role of helix-loop-helix Id2 (inhibitor of DNA binding 2). Graefes Arch Clin Exp Ophthalmol. 2009;247:411-9 pubmed publisher
    ..RNAi (RNA interference) technology was used to examine whether inhibitor of DNA binding 2 (Id2) was involved in the uveal melanoma vasculogenic mimicry...
  58. Vandesompele J, Edsjö A, De Preter K, Axelson H, Speleman F, Påhlman S. ID2 expression in neuroblastoma does not correlate to MYCN levels and lacks prognostic value. Oncogene. 2003;22:456-60 pubmed
    ..Recently, it was reported that the ID2 gene is a direct target for the MYCN and MYC transcription factors, and that ID2 expression and MYCN amplification ..
  59. Rodriguez J, Sandoval J, Serviddio G, Sastre J, Morante M, Perrelli M, et al. Id2 leaves the chromatin of the E2F4-p130-controlled c-myc promoter during hepatocyte priming for liver regeneration. Biochem J. 2006;398:431-7 pubmed
    ..that the molecular mechanisms of liver regeneration are not completely understood prompted us to study the fate of Id2 in proliferating liver...
  60. May A, Frey A, Bogatyreva L, Benkisser Petersen M, Hauschke D, Lubbert M, et al. ID2 and ID3 protein expression mirrors granulopoietic maturation and discriminates between acute leukemia subtypes. Histochem Cell Biol. 2014;141:431-40 pubmed publisher
    ..To elucidate the involvement of IDs in hematopoiesis and acute leukemias (AL), we analyzed ID2 and ID3 expression in hematopoiesis and leukemic blasts in bone marrow biopsies (BMB)...
  61. Kurabayashi M, Jeyaseelan R, Kedes L. Two distinct cDNA sequences encoding the human helix-loop-helix protein Id2. Gene. 1993;133:305-6 pubmed
    Two distinct Id2 cDNA clones, Id2A and Id2B (inhibitor of differentiation), have been isolated from a human heart cDNA library and sequenced...
  62. Tu X, Baffa R, Luke S, Prisco M, Baserga R. Intracellular redistribution of nuclear and nucleolar proteins during differentiation of 32D murine hemopoietic cells. Exp Cell Res. 2003;288:119-30 pubmed
    ..The four proteins studied were the insulin receptor substrate-1 (IRS-1), the ID2 protein, nucleolin, and the upstream binding factor (UBF), all of which are involved directly or indirectly in the ..
  63. Law S, Zhang Y, Fashena S, Toby G, Estojak J, Golemis E. Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain. Exp Cell Res. 1999;252:224-35 pubmed
    ..heterodimerization with a recognition specificity similar to that of the transcriptional regulatory HLH proteins Id2, E12, and E47...
  64. Yanqin Y, Jing T, Wei C, Nan L. Grifolin Attenuates White Matter Lesion in Oxygen/Glucose Deprivation. Transl Neurosci. 2017;8:102-110 pubmed publisher
    ..day of OGD injury for the estimation of expressions of myelin basic protein (MBP) and inhibitor of DNA binding 2 (Id2) in OPCs respectively...
  65. Boareto M, Iber D, Taylor V. Differential interactions between Notch and ID factors control neurogenesis by modulating Hes factor autoregulation. Development. 2017;144:3465-3474 pubmed publisher
    ..Conversely, during adult neurogenesis, Notch signaling and Id2/3 regulate neurogenesis in a complementary manner and ID factors can induce NSC maintenance and quiescence in the ..
  66. Ding B, Liu C, Huang Y, Yu J, Kong W, Lengyel P. p204 protein overcomes the inhibition of the differentiation of P19 murine embryonal carcinoma cells to beating cardiac myocytes by Id proteins. J Biol Chem. 2006;281:14893-906 pubmed
    ..This was in consequence of the binding of Id1, Id2, or Id3 protein to the Gata4 and Nkx2...
  67. Sugai M, Gonda H, Kusunoki T, Katakai T, Yokota Y, Shimizu A. Essential role of Id2 in negative regulation of IgE class switching. Nat Immunol. 2003;4:25-30 pubmed
    ..B cells lacking Id2 have increased E2A activity, which leads to specific enhancement of germline transcription of the immunoglobulin ..
  68. Chandra J, Kuo P, Hahn A, Belz G, Frazer I. Batf3 selectively determines acquisition of CD8+ dendritic cell phenotype and function. Immunol Cell Biol. 2017;95:215-223 pubmed publisher
    ..However, whether Batf3 is absolutely required for the development of CD8+ DCs remains controversial. Id2 is required for CD8+ DC development...
  69. Li H, Liu C, Xiao Y, Chu F, Liang X, Peng W, et al. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal. 2016;9:ra94 pubmed publisher
    ..or melanoma-conditioned medium, rapidly suppressed DC-intrinsic expression of the gene encoding inhibitor of differentiation 2 (ID2), a transcriptional regulator...
  70. Mathas S, Kreher S, Meaburn K, Johrens K, Lamprecht B, Assaf C, et al. Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A. 2009;106:5831-6 pubmed publisher
    ..The affected genes include the oncogenic transcription factor Fra2 (located on 2p23), the HLH protein Id2 (2p25), and the oncogenic tyrosine kinase CSF1-receptor (5q33.1)...
  71. Paolella B, Havrda M, Mantani A, Wray C, Zhang Z, Israel M. p53 directly represses Id2 to inhibit the proliferation of neural progenitor cells. Stem Cells. 2011;29:1090-101 pubmed publisher
    ..We have identified inhibitor of DNA binding 2 (Id2) as a novel target gene directly repressed by p53 to maintain normal NPC proliferation...
  72. Wong M, Jiang S, Palasingam P, Kolatkar P. A divalent ion is crucial in the structure and dominant-negative function of ID proteins, a class of helix-loop-helix transcription regulators. PLoS ONE. 2012;7:e48591 pubmed publisher
    ..We present the high-resolution 2.1Ã… crystal structure of ID2 (HLH domain), coupled with novel biochemical insights in the presence of a divalent ion, possibly calcium (Ca2+), ..
  73. Veerasamy M, Phanish M, Dockrell M. Smad mediated regulation of inhibitor of DNA binding 2 and its role in phenotypic maintenance of human renal proximal tubule epithelial cells. PLoS ONE. 2013;8:e51842 pubmed publisher
    ..The downregulation of one of the members of bHLH family protein, inhibitor of DNA binding 2 (Id2) has been shown to induce de-differentiation of epithelial cells...
  74. Terai S, Aoki H, Ashida K, Thorgeirsson S. Human homologue of maid: A dominant inhibitory helix-loop-helix protein associated with liver-specific gene expression. Hepatology. 2000;32:357-66 pubmed
    ..Comparison of the dominant inhibitory effects of HHM and Id2 on the binding of E12/MyoD dimer to an E-box element revealed a weaker inhibition by HHM...
  75. Chahine M, Deschene I, Chen L, Kallen R. Electrophysiological characteristics of cloned skeletal and cardiac muscle sodium channels. Am J Physiol. 1996;271:H498-506 pubmed
    ..The data on a chimeric channel in which D1 and D4 are derived from hH1 while D2 and D3 and the ID1-2, ID2-3, and ID3-4 loops are from rSkM1 show that D1 and/or D4 seem to be responsible for the slower kinetics of ..
  76. Weigent D. Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. Cell Immunol. 2009;255:46-54 pubmed publisher
    ..of GH in EL4 T lymphoma cells (GHo) also significantly increased levels of the inhibitor of differentiation-2 (Id2). The increase in Id2 was suggested in both Id2 promoter luciferase assays and by Western analysis for Id2 protein...