ID1

Summary

Gene Symbol: ID1
Description: inhibitor of DNA binding 1, HLH protein
Alias: bHLHb24, DNA-binding protein inhibitor ID-1, class B basic helix-loop-helix protein 24, dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein), inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, inhibitor of differentiation 1
Species: human
Products:     ID1

Top Publications

  1. Kim H, Chung H, Kim H, Lee J, Oh M, Kim Y, et al. Id-1 regulates Bcl-2 and Bax expression through p53 and NF-kappaB in MCF-7 breast cancer cells. Breast Cancer Res Treat. 2008;112:287-96 pubmed
    ..In this regard, inactivation of Id-1 may provide a potential therapeutic strategy leading to inhibition of breast cancer progression and anti-cancer drug resistance. ..
  2. Kebebew E. Id1 gene expression and regulation in human thyroid tissue. Thyroid. 2005;15:522-30 pubmed
    The Id genes encode helix-loop-helix (HLH) transcription proteins that lack a DNA binding basic domain. Id proteins (Id1, Id2, Id3, and Id4) function as dominant negative regulators of basic HLH transcription factors by forming inactive ..
  3. Yuen H, Chiu Y, Chan K, Chan Y, Chua C, McCrudden C, et al. Prostate cancer cells modulate osteoblast mineralisation and osteoclast differentiation through Id-1. Br J Cancer. 2010;102:332-41 pubmed publisher
  4. Ling M, Wang X, Ouyang X, Xu K, Tsao S, Wong Y. Id-1 expression promotes cell survival through activation of NF-kappaB signalling pathway in prostate cancer cells. Oncogene. 2003;22:4498-508 pubmed
    ..Our findings also suggest a potential therapeutic strategy in which inactivation of Id-1 may lead to sensitization of prostate cancer cells to chemotherapeutic drug-induced apoptosis. ..
  5. Chambers R, Leoni P, Kaminski N, Laurent G, Heller R. Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching. Am J Pathol. 2003;162:533-46 pubmed
    ..The early induction of two members of the inhibitor of differentiation (ID) family of transcriptional regulators, ID1 and ID3, was followed by the up-regulation of a number of genes that are usually expressed by highly differentiated ..
  6. Trevino J, Pillai S, Kunigal S, Singh S, Fulp W, Centeno B, et al. Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia. 2012;14:1102-14 pubmed
    ..results in activation of Src kinase, which facilitated the induction of the inhibitor of differentiation-1 (Id1) transcription factor...
  7. Sun W, Guo M, Han P, Lin J, Liang F, Tan G, et al. Id-1 and the p65 subunit of NF-?B promote migration of nasopharyngeal carcinoma cells and are correlated with poor prognosis. Carcinogenesis. 2012;33:810-7 pubmed publisher
    ..Id-1 or/and NF-?B/p65 enhanced tumor cell migration, which is associated with the secretion of MMP-9. ..
  8. Li H, Zhuang Z, Wang Q, Pang J, Wang X, Wong H, et al. Epstein-Barr virus latent membrane protein 1 (LMP1) upregulates Id1 expression in nasopharyngeal epithelial cells. Oncogene. 2004;23:4488-94 pubmed
    ..In this study, we report a novel function of LMP1 to induce Id1 expression in nasopharyngeal epithelial cells (NP69) and human embryonal kidney cells (HEK293)...
  9. Maw M, Fujimoto J, Tamaya T. Overexpression of inhibitor of DNA-binding (ID)-1 protein related to angiogenesis in tumor advancement of ovarian cancers. BMC Cancer. 2009;9:430 pubmed publisher
    ..Moreover, ID-1 expression levels correlated with microvessel counts. Therefore, ID-1 might work on tumor advancement via angiogenesis and is considered to be a candidate for a prognostic indicator in ovarian cancers. ..

More Information

Publications78

  1. Ding Y, Wang G, Ling M, Wong Y, Li X, Na Y, et al. Significance of Id-1 up-regulation and its association with EGFR in bladder cancer cell invasion. Int J Oncol. 2006;28:847-54 pubmed
    ..Inactivation of Id-1 may be a potential therapeutic target to inhibit the invasion by bladder cancer cells. ..
  2. Zhang X, Ling M, Wang X, Wong Y. Inactivation of Id-1 in prostate cancer cells: A potential therapeutic target in inducing chemosensitization to taxol through activation of JNK pathway. Int J Cancer. 2006;118:2072-81 pubmed
  3. Wang X, Di K, Zhang X, Han H, Wong Y, Leung S, et al. Id-1 promotes chromosomal instability through modification of APC/C activity during mitosis in response to microtubule disruption. Oncogene. 2008;27:4456-66 pubmed publisher
    ..These results demonstrate a novel function of Id-1 in promoting chromosomal instability through modification of APC/C activity during mitosis and provide a novel molecular mechanism accounted for the function of Id-1 as an oncogene. ..
  4. Si C, Guo J, Yang Y, Zhang N, Pan C, Zhang Q, et al. Nuclear and cytoplasmic Id-1 expression patterns play different roles in angiogenesis and lymphangiogenesis in gastric carcinoma. Ann Diagn Pathol. 2011;15:46-51 pubmed publisher
    ..05). Aberrant expression of Id-1 from nuclear to cytoplasm is accompanied with tumor malignant progression, which promotes angiogenesis and lymphangiogenesis; and Id-1 should be developed as a target for gastric carcinoma therapy. ..
  5. Schmidt M, Asirvatham A, Chaudhary J. Inhibitor of differentiation 1 (ID1) promotes cell survival and proliferation of prostate epithelial cells. Cell Mol Biol Lett. 2010;15:272-95 pubmed publisher
    Id1 (inhibitor of differentiation 1) is a member of the bHLH protein family...
  6. Li B, Tsao S, Li Y, Wang X, Ling M, Wong Y, et al. Id-1 promotes tumorigenicity and metastasis of human esophageal cancer cells through activation of PI3K/AKT signaling pathway. Int J Cancer. 2009;125:2576-85 pubmed publisher
    ..In conclusion, our results provide the first evidence that Id-1 promotes tumorigenicity and metastasis of human esophageal cancer in vivo and that the PI3K inhibitor LY294002 can attenuate these effects. ..
  7. Shuno Y, Tsuno N, Okaji Y, Tsuchiya T, Sakurai D, Nishikawa T, et al. Id1/Id3 knockdown inhibits metastatic potential of pancreatic cancer. J Surg Res. 2010;161:76-82 pubmed publisher
    ..In the present study, we aimed to evaluate the effects of Id inhibition in human pancreatic cancer cells. Id1 and Id3 were stably double-knockdown in human pancreatic cancer cell line MIA-Paca2 by means of RNA interference...
  8. Cheng Y, Tsai J, Hsieh K, Yang Y, Chen Y, Huang M, et al. Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway. Cancer Lett. 2011;307:191-9 pubmed publisher
    ..Although Id1 is the Id family member mostly linked to tumorigenesis, its role in lung cancer is unclear...
  9. Ohtani N, Zebedee Z, Huot T, Stinson J, Sugimoto M, Ohashi Y, et al. Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature. 2001;409:1067-70 pubmed
    ..through the Ras-Raf-MEK kinase cascade and inhibited by a direct interaction with the helix-loop-helix protein Id1 (ref. 11)...
  10. Hara E, Yamaguchi T, Nojima H, Ide T, Campisi J, Okayama H, et al. Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts. J Biol Chem. 1994;269:2139-45 pubmed
    ..SVts8 cells may acquire some function redundant to Id proteins. HT1080 fibrosarcoma cells expressed the Id-1H gene but not the Id-2H gene, suggesting these Id genes may subserve redundant functions. ..
  11. Trausch Azar J, Lingbeck J, Ciechanover A, Schwartz A. Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD. J Biol Chem. 2004;279:32614-9 pubmed
    ..Following transfection to HeLa cells, Id1 is localized to the nucleus and rapidly (t(1/2) approximately 1 h) degraded via the ubiquitin-proteasome system...
  12. Ling M, Lau T, Zhou C, Chua C, Kwok W, Wang Q, et al. Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF). Carcinogenesis. 2005;26:1668-76 pubmed
    ..Since increased Id-1 has been reported in many types of advanced human cancers, our results indicate that downregulation of Id-1 may be a novel target to inhibit the growth of metastatic cancers through the suppression of angiogenesis. ..
  13. Anand G, Yin X, Shahidi A, Grove L, Prochownik E. Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome. J Biol Chem. 1997;272:19140-51 pubmed
    ..In a search for novel factors that interact with Id1, we identified a component of the 26 S proteasome, S5a, that has previously been implicated only in the recognition ..
  14. Hasskarl J, Mern D, Munger K. Interference of the dominant negative helix-loop-helix protein ID1 with the proteasomal subunit S5A causes centrosomal abnormalities. Oncogene. 2008;27:1657-64 pubmed
    ..Ectopic ID1 expression extends the life span of primary human epithelial cells, inhibits cellular differentiation and induces ..
  15. Zhao Z, Zhang Z, Zhang H, Jiang L, Wang M, Sun X. Overexpression of Id-1 protein is a marker in colorectal cancer progression. Oncol Rep. 2008;19:419-24 pubmed
    ..The cases with lymph node metastasis had a higher rate of a stronger Id-1 expression than those without lymph node metastasis. In conclusion, Id-1 overexpression plays an important role in colorectal cancer progression. ..
  16. Kim H, Chung H, Yoo Y, Kim H, Lee J, Lee M, et al. Inhibitor of DNA binding 1 activates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1alpha. Mol Cancer Res. 2007;5:321-9 pubmed
    ..In conclusion, we provide the molecular mechanism of the cross talk between HIF-1alpha and Id-1, which may play a critical role in tumor angiogenesis. ..
  17. Tsuchiya T, Okaji Y, Tsuno N, Sakurai D, Tsuchiya N, Kawai K, et al. Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancer. Cancer Sci. 2005;96:784-90 pubmed
    ..an attempt to develop new strategies for the treatment of peritoneal metastasis of gastric cancer, we prepared an Id1, 3 double-knockdown gastric cancer cell line, MKN45, by RNA interference and investigated its effects on the ..
  18. Yu X, Xu X, Han B, Zhou R. Inhibitor of DNA binding-1 overexpression in prostate cancer: relevance to tumor differentiation. Pathol Oncol Res. 2009;15:91-6 pubmed publisher
    Inhibitor of DNA binding-1 (Id1) is a dominant-negative regulator of basic helix-loop-helix transcription factor, which control malignant cell behaviors in several types of carcinomas...
  19. Maw M, Fujimoto J, Tamaya T. Expression of the inhibitor of DNA-binding (ID)-1 protein as an angiogenic mediator in tumour advancement of uterine cervical cancers. Br J Cancer. 2008;99:1557-63 pubmed publisher
    ..Therefore, ID-1 might work on tumour advancement through angiogenic activity and is considered to be a candidate for a prognostic indicator in uterine cervical cancers. ..
  20. Liang Y, Brunicardi F, Lin X. Smad3 mediates immediate early induction of Id1 by TGF-beta. Cell Res. 2009;19:140-8 pubmed publisher
    b>Id1 is a member of the inhibitor of differentiation (Id) protein family that regulates a wide range of cell functions...
  21. Damdinsuren B, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Yamamoto T, et al. Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Int J Oncol. 2005;26:319-27 pubmed
    ..We examined the immunohistochemical expression of Id1, Id2 and Id3 proteins in 54 surgically resected HCCs with surrounding HCV or HBV-related chronic hepatitis (n=30) ..
  22. Han S, Gou C, Hong L, Liu J, ZheyiHan -, Liu C, et al. Expression and significances of Id1 helix-loop-helix protein overexpression in gastric cancer. Cancer Lett. 2004;216:63-71 pubmed
    ..Our results demonstrate that Idl protein may play an important role in the process of gastric carcinogenesis and high-level Id I expression may be related to the malignant potential of tumor cells. ..
  23. Mern D, Hoppe Seyler K, Hoppe Seyler F, Hasskarl J, Burwinkel B. Targeting Id1 and Id3 by a specific peptide aptamer induces E-box promoter activity, cell cycle arrest, and apoptosis in breast cancer cells. Breast Cancer Res Treat. 2010;124:623-33 pubmed publisher
    ..Overexpression of Id proteins, especially Id1, correlates with unfavorable clinical prognosis. Thus, they are attractive molecular targets for anticancer therapy...
  24. Pillai S, Rizwani W, Li X, Rawal B, Nair S, Schell M, et al. ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling. Mol Cell Biol. 2011;31:3052-67 pubmed publisher
    Expression of ID1 (inhibitor of differentiation) has been correlated with the progression of a variety of cancers, but little information is available on its role in non-small cell lung cancer (NSCLC)...
  25. Kong Y, Cui H, Zhang H. Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence. Aging Cell. 2011;10:1038-46 pubmed publisher
    ..Here, we report for the first time the identification of Smurf2 as the E3 ligase that ubiquitinates Id1 and Id3...
  26. O Brien C, Kreso A, Ryan P, Hermans K, Gibson L, Wang Y, et al. ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. Cancer Cell. 2012;21:777-92 pubmed publisher
    ..Here, we establish that ID1 and ID3 function together to govern colon cancer-initiating cell (CC-IC) self-renewal through cell-cycle ..
  27. Soroceanu L, Murase R, Limbad C, Singer E, Allison J, Adrados I, et al. Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target. Cancer Res. 2013;73:1559-69 pubmed publisher
    ..Our results suggest that Id-1 regulates multiple tumor-promoting pathways in glioblastoma and that drugs targeting Id-1 represent a novel and promising strategy for improving the therapy and outcome of patients with glioblastoma. ..
  28. Sun X, Li C, Zhuang C, Gilmore W, Cobos E, Tao Y, et al. Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells. Carcinogenesis. 2009;30:2109-16 pubmed publisher
    ..novel function for Abi1 in the regulation of invadopodia formation and Src-inhibitor of differentiation protein 1 (Id1)-matrix metalloproteinase (MMP)-9 pathway in MDA-MB-231 human breast cancer cells...
  29. Yuen H, Chan Y, Chan K, Chu Y, Wong M, Law S, et al. Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma. Br J Cancer. 2007;97:1409-15 pubmed
    ..Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. ..
  30. Li B, Tsao S, Chan K, Ludwig D, Novosyadlyy R, Li Y, et al. Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance--implications for IGF-II and IGF-IR-targeted therapy. Clin Cancer Res. 2014;20:2651-62 pubmed publisher
    To investigate the autocrine/endocrine role of Id1-induced insulin-like growth factor-II (IGF-II) in esophageal cancer, and evaluate the potential of IGF-II- and IGF-type I receptor (IGF-IR)-targeted therapies...
  31. Chen K, Chen C, Tseng Y, Chang Y, Chang M. GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotion. Oncotarget. 2014;5:5017-28 pubmed
    ..Binding assays indicated that inhibitor of DNA binding/differentiation 1 (Id1) interacts with GCIP in the nucleus...
  32. Li Y, Yang J, Luo J, Dedhar S, Liu Y. Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1. J Am Soc Nephrol. 2007;18:449-60 pubmed
    ..Inhibitor of differentiation-1 (Id1), a dominant negative antagonist of the basic helix-loop-helix transcription factors, was found to be induced ..
  33. Langlands K, Down G, Kealey T. Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma. Cancer Res. 2000;60:5929-33 pubmed
    ..In squamous cell carcinoma of the head and neck, Id protein immunoreactivity was observed in the majority of malignant keratinocytes in the most poorly differentiated sections, with reduced staining in well-differentiated disease. ..
  34. Zhang X, Ling M, Wang Q, Lau C, Leung S, Lee T, et al. Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells. J Biol Chem. 2007;282:33284-94 pubmed
  35. Korchynskyi O, Ten Dijke P. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J Biol Chem. 2002;277:4883-91 pubmed
    ..Here we report that Id1, a dominant negative inhibitor of basic helix-loop-helix proteins, is a direct target gene for BMP...
  36. Coppe J, Itahana Y, Moore D, Bennington J, Desprez P. Id-1 and Id-2 proteins as molecular markers for human prostate cancer progression. Clin Cancer Res. 2004;10:2044-51 pubmed
    ..We propose that both Id-1 and Id-2 proteins control prostate cancer cell phenotypes and could serve as molecular markers of aggressive human prostate cancer. ..
  37. Straume O, Akslen L. Strong expression of ID1 protein is associated with decreased survival, increased expression of ephrin-A1/EPHA2, and reduced thrombospondin-1 in malignant melanoma. Br J Cancer. 2005;93:933-8 pubmed
    The ID1 protein, an inhibitor of basic helix-loop-helix transcription factors, has been involved in multiple cellular processes including cell cycle regulation, apoptosis, and angiogenesis...
  38. Zheng W, Wang H, Xue L, Zhang Z, Tong T. Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast. J Biol Chem. 2004;279:31524-32 pubmed
    b>Id1, a member of Id family of helix-loop-helix transcriptional regulatory proteins, is implicated in cellular senescence by repressing p16(INK4a) expression, but the mechanisms and cellular effects in human diploid fibroblasts remain ..
  39. Lee T, Man K, Ling M, Wang X, Wong Y, Lo C, et al. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway. Carcinogenesis. 2003;24:1729-36 pubmed
    ..In conclusion, the results provided an insight for the understanding of the role of Id-1 in functional inactivation of p16INK4a in HCC. ..
  40. Schindl M, Schoppmann S, Strobel T, Heinzl H, Leisser C, Horvat R, et al. Level of Id-1 protein expression correlates with poor differentiation, enhanced malignant potential, and more aggressive clinical behavior of epithelial ovarian tumors. Clin Cancer Res. 2003;9:779-85 pubmed
    ..Consequently, Id-1 inhibition in the future might be of benefit for patients with ovarian cancer. ..
  41. Tang J, Gordon G, Müller M, Dahiya M, Foreman K. Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen induces expression of the helix-loop-helix protein Id-1 in human endothelial cells. J Virol. 2003;77:5975-84 pubmed
    ..This may be an important mechanism by which KSHV allows KS tumor cells to escape normal cell cycle regulation and enhances their proliferation. ..
  42. Lee J, Kang M, Jang S, Qian T, Kim H, Kim C, et al. Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition. Oncogene. 2009;28:824-31 pubmed publisher
  43. Rothschild S, Kappeler A, Ratschiller D, Betticher D, Tschan M, Gugger M, et al. The stem cell gene "inhibitor of differentiation 1" (ID1) is frequently expressed in non-small cell lung cancer. Lung Cancer. 2011;71:306-11 pubmed publisher
    b>Inhibitor of differentiation 1 (ID1) plays a role in cellular differentiation, proliferation, angiogenesis and tumor invasion...
  44. Hasskarl J, Duensing S, Manuel E, Munger K. The helix-loop-helix protein ID1 localizes to centrosomes and rapidly induces abnormal centrosome numbers. Oncogene. 2004;23:1930-8 pubmed
    b>ID1 is a member of the inhibitor of DNA binding/differentiation (ID) family of dominant negative helix-loop-helix transcription factors...
  45. Hamajima Y, Komori M, Preciado D, Choo D, Moribe K, Murakami S, et al. The role of inhibitor of DNA-binding (Id1) in hyperproliferation of keratinocytes: the pathological basis for middle ear cholesteatoma from chronic otitis media. Cell Prolif. 2010;43:457-63 pubmed publisher
    ..The purpose of this study was to investigate the cellular proliferation and keratin production of keratinocytes under the influence of Id1, a candidate transcription factor to cell proliferation.
  46. Buitenhuis M, van Deutekom H, Verhagen L, Castor A, Jacobsen S, Lammers J, et al. Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2. Blood. 2005;105:4272-81 pubmed
    ..In this study, we have investigated the role of Id1 and Id2 in the regulation of granulopoiesis...
  47. Man C, Rosa J, Yip Y, Cheung A, Kwong Y, Doxsey S, et al. Id1 overexpression induces tetraploidization and multiple abnormal mitotic phenotypes by modulating aurora A. Mol Biol Cell. 2008;19:2389-401 pubmed publisher
    The basic helix-loop-helix transcription factor, Id1, was shown to induce tetraploidy in telomerase-immortalized nasopharyngeal epithelial cells in this study...
  48. Lee T, Poon R, Yuen A, Ling M, Wang X, Wong Y, et al. Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. Clin Cancer Res. 2006;12:6910-9 pubmed
    ..Id-1 is a novel angiogenic factor for HCC metastasis and down-regulation of Id-1 may be a novel target to inhibit HCC metastasis through suppression of angiogenesis. ..
  49. Darby S, Cross S, Brown N, Hamdy F, Robson C. BMP-6 over-expression in prostate cancer is associated with increased Id-1 protein and a more invasive phenotype. J Pathol. 2008;214:394-404 pubmed
    ..001) across all samples for both benign and cancer cases. These data demonstrate that BMP-6 promotes migration and invasion of prostate cancer cells, potentially through activation of Id-1 and MMP activation. ..
  50. Manthey C, Mern D, Gutmann A, Zielinski A, Herz C, Lassmann S, et al. Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells. BMC Cell Biol. 2010;11:2 pubmed publisher
    ..Ectopic (over-)expression of ID1 extends the lifespan of primary human epithelial cells...
  51. Li Y, Wen X, Liu Y. Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis. Kidney Int. 2012;81:880-91 pubmed publisher
    ..We previously identified the inhibitor of differentiation-1 (Id1), a dominant negative antagonist of basic helix-loop-helix transcription factors, as a major trigger of tubular ..
  52. Singh J, Murata K, Itahana Y, Desprez P. Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex. Oncogene. 2002;21:1812-22 pubmed
    ..On the basis of these findings, we propose a mechanism for the loss of regulation of Id-1 promoter in invasive and metastatic human breast cancer cells. ..
  53. Ling M, Wang X, Lee D, Tam P, Tsao S, Wong Y. Id-1 expression induces androgen-independent prostate cancer cell growth through activation of epidermal growth factor receptor (EGF-R). Carcinogenesis. 2004;25:517-25 pubmed
    ..Inactivation of Id-1 may provide a potential therapeutic strategy leading to inhibition of androgen-independent prostate cancer cell growth. ..
  54. Yates P, Atherton G, Deed R, Norton J, Sharrocks A. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 1999;18:968-76 pubmed
    ..Therefore, our results demonstrate a novel facet of Id function in the coordination of mitogenic signalling and cell cycle entry. ..
  55. Cheung H, Ling M, Tsao S, Wong Y, Wang X. Id-1-induced Raf/MEK pathway activation is essential for its protective role against taxol-induced apoptosis in nasopharyngeal carcinoma cells. Carcinogenesis. 2004;25:881-7 pubmed
    ..Our evidence also indicates a novel treatment strategy to increase anticancer drug-induced apoptosis through inactivation of the Id-1 protein. ..
  56. Yang H, Liu H, Liu G, Zhu H, Meng Q, Qu L, et al. Expression and prognostic values of Id-1 and Id-3 in gastric adenocarcinoma. J Surg Res. 2011;167:258-66 pubmed publisher
    ..Consequently, Id-3 might be used to independently predict survival of patients with gastric cancer. ..
  57. Swarbrick A, Akerfeldt M, Lee C, Sergio C, Caldon C, Hunter L, et al. Regulation of cyclin expression and cell cycle progression in breast epithelial cells by the helix-loop-helix protein Id1. Oncogene. 2005;24:381-9 pubmed
    The helix-loop-helix protein Id1 has been implicated in regulating mammary epithelial cell proliferation and differentiation but the underlying molecular mechanisms are not well characterized...
  58. Lingbeck J, Trausch Azar J, Ciechanover A, Schwartz A. E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1. Oncogene. 2005;24:6376-84 pubmed
    ..In muscle, the degradation of the muscle transcription factor MyoD and its inhibitor Id1 occurs via the ubiquitin-proteasome system...
  59. Ling M, Kwok W, Fung M, Xianghong W, Wong Y. Proteasome mediated degradation of Id-1 is associated with TNFalpha-induced apoptosis in prostate cancer cells. Carcinogenesis. 2006;27:205-15 pubmed
  60. Caldon C, Swarbrick A, Lee C, Sutherland R, Musgrove E. The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini. Cancer Res. 2008;68:3026-36 pubmed publisher
    Overexpression of the helix-loop-helix (HLH) protein Id1 has been associated with metastasis in breast cancer, but its role in models of early breast tumorigenesis is not well characterized...
  61. Jang K, Han H, Paik S, Brown P, Kong G. Id-1 overexpression in invasive ductal carcinoma cells is significantly associated with intratumoral microvessel density in ER-negative/node-positive breast cancer. Cancer Lett. 2006;244:203-10 pubmed
    ..Thus, Id-1 presents a possible therapeutic antitumor target molecule in ER-negative and node-positive breast cancer. ..
  62. Hui C, Cheung P, Ling M, Tsao S, Wang X, Wong Y, et al. Id-1 promotes proliferation of p53-deficient esophageal cancer cells. Int J Cancer. 2006;119:508-14 pubmed
  63. Lee K, Lee Y, Lee J, Choi S, Rhee J, Paik S, et al. Overexpression of Id-1 is significantly associated with tumour angiogenesis in human pancreas cancers. Br J Cancer. 2004;90:1198-203 pubmed
  64. Poomthavorn P, Wong S, Higgins S, Werther G, Russo V. Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells. Endocr Relat Cancer. 2009;16:991-1004 pubmed publisher
    ..followed by the increase of mRNA for vascular endothelial growth factor (VEGF) and nuclear accumulation of the ID1-2 transcription factors by 4 h...
  65. Kim M, Park T, Lee Y, Jo Y, Kim S. Expression of Id-1 and VEGF in non-small cell lung cancer. Int J Clin Exp Pathol. 2013;6:2102-11 pubmed
    ..Id-1 may function in tumor growth and progression via angiogenesis. Therefore, Id-1 is considered to be a candidate for new therapeutic target and a prognostic factor in NSCLC. ..
  66. Katagiri T, Imada M, Yanai T, Suda T, Takahashi N, Kamijo R. Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis. Genes Cells. 2002;7:949-60 pubmed
    ..BMP-2 induces transcription of Id1, an inhibitor for myogenesis, within 1 h in the cells...
  67. Ouyang X, Wang X, Ling M, Wong H, Tsao S, Wong Y. Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway. Carcinogenesis. 2002;23:721-5 pubmed
    ..Given the fact that both Id-1 over-expression and inactivation of p16(INK4a)/pRB are common events in prostate cancer, our results provide a possible mechanism on the molecular basis of prostate carcinogenesis. ..
  68. Castañon E, Bosch Barrera J, Lopez I, Collado V, Moreno M, Lopez Picazo J, et al. Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy. J Transl Med. 2013;11:13 pubmed publisher
    Inhibitor of DNA binding 1 (Id1) and 3 (Id3) genes have been related with the inhibition of cell differentiation, cell growth promotion and tumor metastasis...
  69. Forootan S, Wong Y, Dodson A, Wang X, Lin K, Smith P, et al. Increased Id-1 expression is significantly associated with poor survival of patients with prostate cancer. Hum Pathol. 2007;38:1321-9 pubmed
    ..01). These results suggest that Id-1 is a useful prognostic marker to predict the outcomes of patients with prostate cancer. ..