ID1

Summary

Gene Symbol: ID1
Description: inhibitor of DNA binding 1, HLH protein
Alias: bHLHb24, DNA-binding protein inhibitor ID-1, class B basic helix-loop-helix protein 24, dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein), inhibitor of DNA binding 1, dominant negative helix-loop-helix protein, inhibitor of differentiation 1
Species: human
Products:     ID1

Top Publications

  1. Anand G, Yin X, Shahidi A, Grove L, Prochownik E. Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome. J Biol Chem. 1997;272:19140-51 pubmed
    ..In a search for novel factors that interact with Id1, we identified a component of the 26 S proteasome, S5a, that has previously been implicated only in the recognition ..
  2. Trausch Azar J, Lingbeck J, Ciechanover A, Schwartz A. Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD. J Biol Chem. 2004;279:32614-9 pubmed
    ..Following transfection to HeLa cells, Id1 is localized to the nucleus and rapidly (t(1/2) approximately 1 h) degraded via the ubiquitin-proteasome system...
  3. Cheng Y, Tsai J, Hsieh K, Yang Y, Chen Y, Huang M, et al. Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway. Cancer Lett. 2011;307:191-9 pubmed publisher
    ..Although Id1 is the Id family member mostly linked to tumorigenesis, its role in lung cancer is unclear...
  4. Kim H, Chung H, Yoo Y, Kim H, Lee J, Lee M, et al. Inhibitor of DNA binding 1 activates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1alpha. Mol Cancer Res. 2007;5:321-9 pubmed
    ..In conclusion, we provide the molecular mechanism of the cross talk between HIF-1alpha and Id-1, which may play a critical role in tumor angiogenesis. ..
  5. Damdinsuren B, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Yamamoto T, et al. Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Int J Oncol. 2005;26:319-27 pubmed
    ..We examined the immunohistochemical expression of Id1, Id2 and Id3 proteins in 54 surgically resected HCCs with surrounding HCV or HBV-related chronic hepatitis (n=30) ..
  6. Hasskarl J, Mern D, Munger K. Interference of the dominant negative helix-loop-helix protein ID1 with the proteasomal subunit S5A causes centrosomal abnormalities. Oncogene. 2008;27:1657-64 pubmed
    ..Ectopic ID1 expression extends the life span of primary human epithelial cells, inhibits cellular differentiation and induces ..
  7. Kong Y, Cui H, Zhang H. Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence. Aging Cell. 2011;10:1038-46 pubmed publisher
    ..Here, we report for the first time the identification of Smurf2 as the E3 ligase that ubiquitinates Id1 and Id3...
  8. O Brien C, Kreso A, Ryan P, Hermans K, Gibson L, Wang Y, et al. ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. Cancer Cell. 2012;21:777-92 pubmed publisher
    ..Here, we establish that ID1 and ID3 function together to govern colon cancer-initiating cell (CC-IC) self-renewal through cell-cycle ..
  9. Sun X, Li C, Zhuang C, Gilmore W, Cobos E, Tao Y, et al. Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells. Carcinogenesis. 2009;30:2109-16 pubmed publisher
    ..novel function for Abi1 in the regulation of invadopodia formation and Src-inhibitor of differentiation protein 1 (Id1)-matrix metalloproteinase (MMP)-9 pathway in MDA-MB-231 human breast cancer cells...
  10. Yuen H, Chan Y, Chan K, Chu Y, Wong M, Law S, et al. Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma. Br J Cancer. 2007;97:1409-15 pubmed
    ..Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. ..

Detail Information

Publications62

  1. Anand G, Yin X, Shahidi A, Grove L, Prochownik E. Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome. J Biol Chem. 1997;272:19140-51 pubmed
    ..In a search for novel factors that interact with Id1, we identified a component of the 26 S proteasome, S5a, that has previously been implicated only in the recognition ..
  2. Trausch Azar J, Lingbeck J, Ciechanover A, Schwartz A. Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD. J Biol Chem. 2004;279:32614-9 pubmed
    ..Following transfection to HeLa cells, Id1 is localized to the nucleus and rapidly (t(1/2) approximately 1 h) degraded via the ubiquitin-proteasome system...
  3. Cheng Y, Tsai J, Hsieh K, Yang Y, Chen Y, Huang M, et al. Id1 promotes lung cancer cell proliferation and tumor growth through Akt-related pathway. Cancer Lett. 2011;307:191-9 pubmed publisher
    ..Although Id1 is the Id family member mostly linked to tumorigenesis, its role in lung cancer is unclear...
  4. Kim H, Chung H, Yoo Y, Kim H, Lee J, Lee M, et al. Inhibitor of DNA binding 1 activates vascular endothelial growth factor through enhancing the stability and activity of hypoxia-inducible factor-1alpha. Mol Cancer Res. 2007;5:321-9 pubmed
    ..In conclusion, we provide the molecular mechanism of the cross talk between HIF-1alpha and Id-1, which may play a critical role in tumor angiogenesis. ..
  5. Damdinsuren B, Nagano H, Kondo M, Yamamoto H, Hiraoka N, Yamamoto T, et al. Expression of Id proteins in human hepatocellular carcinoma: relevance to tumor dedifferentiation. Int J Oncol. 2005;26:319-27 pubmed
    ..We examined the immunohistochemical expression of Id1, Id2 and Id3 proteins in 54 surgically resected HCCs with surrounding HCV or HBV-related chronic hepatitis (n=30) ..
  6. Hasskarl J, Mern D, Munger K. Interference of the dominant negative helix-loop-helix protein ID1 with the proteasomal subunit S5A causes centrosomal abnormalities. Oncogene. 2008;27:1657-64 pubmed
    ..Ectopic ID1 expression extends the life span of primary human epithelial cells, inhibits cellular differentiation and induces ..
  7. Kong Y, Cui H, Zhang H. Smurf2-mediated ubiquitination and degradation of Id1 regulates p16 expression during senescence. Aging Cell. 2011;10:1038-46 pubmed publisher
    ..Here, we report for the first time the identification of Smurf2 as the E3 ligase that ubiquitinates Id1 and Id3...
  8. O Brien C, Kreso A, Ryan P, Hermans K, Gibson L, Wang Y, et al. ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21. Cancer Cell. 2012;21:777-92 pubmed publisher
    ..Here, we establish that ID1 and ID3 function together to govern colon cancer-initiating cell (CC-IC) self-renewal through cell-cycle ..
  9. Sun X, Li C, Zhuang C, Gilmore W, Cobos E, Tao Y, et al. Abl interactor 1 regulates Src-Id1-matrix metalloproteinase 9 axis and is required for invadopodia formation, extracellular matrix degradation and tumor growth of human breast cancer cells. Carcinogenesis. 2009;30:2109-16 pubmed publisher
    ..novel function for Abi1 in the regulation of invadopodia formation and Src-inhibitor of differentiation protein 1 (Id1)-matrix metalloproteinase (MMP)-9 pathway in MDA-MB-231 human breast cancer cells...
  10. Yuen H, Chan Y, Chan K, Chu Y, Wong M, Law S, et al. Id-1 and Id-2 are markers for metastasis and prognosis in oesophageal squamous cell carcinoma. Br J Cancer. 2007;97:1409-15 pubmed
    ..Our results suggest that Id-1 may promote distant metastasis in ESCC, and both Id-1 and Id-2 may be used for prognostication for ESCC patients. ..
  11. Zhang X, Ling M, Wang Q, Lau C, Leung S, Lee T, et al. Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells. J Biol Chem. 2007;282:33284-94 pubmed
    ....
  12. Li B, Tsao S, Chan K, Ludwig D, Novosyadlyy R, Li Y, et al. Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance--implications for IGF-II and IGF-IR-targeted therapy. Clin Cancer Res. 2014;20:2651-62 pubmed publisher
    To investigate the autocrine/endocrine role of Id1-induced insulin-like growth factor-II (IGF-II) in esophageal cancer, and evaluate the potential of IGF-II- and IGF-type I receptor (IGF-IR)-targeted therapies...
  13. Chen K, Chen C, Tseng Y, Chang Y, Chang M. GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotion. Oncotarget. 2014;5:5017-28 pubmed
    ..Binding assays indicated that inhibitor of DNA binding/differentiation 1 (Id1) interacts with GCIP in the nucleus...
  14. Lee T, Man K, Ling M, Wang X, Wong Y, Lo C, et al. Over-expression of Id-1 induces cell proliferation in hepatocellular carcinoma through inactivation of p16INK4a/RB pathway. Carcinogenesis. 2003;24:1729-36 pubmed
    ..In conclusion, the results provided an insight for the understanding of the role of Id-1 in functional inactivation of p16INK4a in HCC. ..
  15. Zheng W, Wang H, Xue L, Zhang Z, Tong T. Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast. J Biol Chem. 2004;279:31524-32 pubmed
    b>Id1, a member of Id family of helix-loop-helix transcriptional regulatory proteins, is implicated in cellular senescence by repressing p16(INK4a) expression, but the mechanisms and cellular effects in human diploid fibroblasts remain ..
  16. Darby S, Cross S, Brown N, Hamdy F, Robson C. BMP-6 over-expression in prostate cancer is associated with increased Id-1 protein and a more invasive phenotype. J Pathol. 2008;214:394-404 pubmed
    ..001) across all samples for both benign and cancer cases. These data demonstrate that BMP-6 promotes migration and invasion of prostate cancer cells, potentially through activation of Id-1 and MMP activation. ..
  17. Hamajima Y, Komori M, Preciado D, Choo D, Moribe K, Murakami S, et al. The role of inhibitor of DNA-binding (Id1) in hyperproliferation of keratinocytes: the pathological basis for middle ear cholesteatoma from chronic otitis media. Cell Prolif. 2010;43:457-63 pubmed publisher
    ..The purpose of this study was to investigate the cellular proliferation and keratin production of keratinocytes under the influence of Id1, a candidate transcription factor to cell proliferation.
  18. Lee J, Kang M, Jang S, Qian T, Kim H, Kim C, et al. Id-1 activates Akt-mediated Wnt signaling and p27(Kip1) phosphorylation through PTEN inhibition. Oncogene. 2009;28:824-31 pubmed publisher
    ....
  19. Li Y, Wen X, Liu Y. Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis. Kidney Int. 2012;81:880-91 pubmed publisher
    ..We previously identified the inhibitor of differentiation-1 (Id1), a dominant negative antagonist of basic helix-loop-helix transcription factors, as a major trigger of tubular ..
  20. Singh J, Murata K, Itahana Y, Desprez P. Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex. Oncogene. 2002;21:1812-22 pubmed
    ..On the basis of these findings, we propose a mechanism for the loss of regulation of Id-1 promoter in invasive and metastatic human breast cancer cells. ..
  21. Yates P, Atherton G, Deed R, Norton J, Sharrocks A. Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors. EMBO J. 1999;18:968-76 pubmed
    ..Therefore, our results demonstrate a novel facet of Id function in the coordination of mitogenic signalling and cell cycle entry. ..
  22. Caldon C, Swarbrick A, Lee C, Sutherland R, Musgrove E. The helix-loop-helix protein Id1 requires cyclin D1 to promote the proliferation of mammary epithelial cell acini. Cancer Res. 2008;68:3026-36 pubmed publisher
    Overexpression of the helix-loop-helix (HLH) protein Id1 has been associated with metastasis in breast cancer, but its role in models of early breast tumorigenesis is not well characterized...
  23. Lingbeck J, Trausch Azar J, Ciechanover A, Schwartz A. E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1. Oncogene. 2005;24:6376-84 pubmed
    ..In muscle, the degradation of the muscle transcription factor MyoD and its inhibitor Id1 occurs via the ubiquitin-proteasome system...
  24. Poomthavorn P, Wong S, Higgins S, Werther G, Russo V. Activation of a prometastatic gene expression program in hypoxic neuroblastoma cells. Endocr Relat Cancer. 2009;16:991-1004 pubmed publisher
    ..followed by the increase of mRNA for vascular endothelial growth factor (VEGF) and nuclear accumulation of the ID1-2 transcription factors by 4 h...
  25. Ouyang X, Wang X, Ling M, Wong H, Tsao S, Wong Y. Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway. Carcinogenesis. 2002;23:721-5 pubmed
    ..Given the fact that both Id-1 over-expression and inactivation of p16(INK4a)/pRB are common events in prostate cancer, our results provide a possible mechanism on the molecular basis of prostate carcinogenesis. ..
  26. CastaƱon E, Bosch Barrera J, Lopez I, Collado V, Moreno M, Lopez Picazo J, et al. Id1 and Id3 co-expression correlates with clinical outcome in stage III-N2 non-small cell lung cancer patients treated with definitive chemoradiotherapy. J Transl Med. 2013;11:13 pubmed publisher
    Inhibitor of DNA binding 1 (Id1) and 3 (Id3) genes have been related with the inhibition of cell differentiation, cell growth promotion and tumor metastasis...