ICOS

Summary

Gene Symbol: ICOS
Description: inducible T cell costimulator
Alias: AILIM, CD278, CVID1, inducible T-cell costimulator, activation-inducible lymphocyte immunomediatory molecule, inducible T-cell co-stimulator, inducible costimulator
Species: human
Products:     ICOS

Top Publications

  1. Kaartinen T, Lappalainen J, Haimila K, Autero M, Partanen J. Genetic variation in ICOS regulates mRNA levels of ICOS and splicing isoforms of CTLA4. Mol Immunol. 2007;44:1644-51 pubmed
    ..functional studies suggest that polymorphism in cytotoxic T lymphocyte-associated antigen-4 (CTLA4) and inducible costimulator (ICOS) genes, both reported to harbour autoimmune susceptibility loci, could regulate the immune ..
  2. Haaning Andersen A, Lange M, Lillevang S. Allelic variation of the inducible costimulator (ICOS) gene: detection of polymorphisms, analysis of the promoter region, and extended haplotype estimation. Tissue Antigens. 2003;61:276-85 pubmed
    The human chromosome region 2q33 including the three costimulatory molecules CD28, CTLA-4 and ICOS, has been subject to much attention due to its linkage to a number of autoimmune diseases...
  3. Wang S, Zhu G, Chapoval A, Dong H, Tamada K, Ni J, et al. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood. 2000;96:2808-13 pubmed
    ..Ig) fusion protein, B7-H2Ig, binds activated but not resting T cells and the binding is abrogated by inducible costimulator Ig (ICOSIg), but not CTLA4Ig...
  4. Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, et al. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med. 2000;192:1545-52 pubmed
    ..express high levels of CD40 ligand (CD40L), a costimulatory molecule required for B cell activation and inducible costimulator (ICOS), a recently identified costimulatory molecule of the CD28 family...
  5. Beier K, Hutloff A, Dittrich A, Heuck C, Rauch A, Buchner K, et al. Induction, binding specificity and function of human ICOS. Eur J Immunol. 2000;30:3707-17 pubmed
    Recently, we have identified the inducible co-stimulator (ICOS), an activation-dependent, T cell-specific cell surface molecule related to CD28 and CTLA-4...
  6. Yu D, Tan A, Hu X, Athanasopoulos V, Simpson N, Silva D, et al. Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature. 2007;450:299-303 pubmed publisher
    ..by limiting the levels on T lymphocytes of aco-stimulatory receptor, the inducible T-cell co-stimulator(ICOS)...
  7. Zhang Q, Wang H, Kantekure K, Paterson J, Liu X, Schaffer A, et al. Oncogenic tyrosine kinase NPM-ALK induces expression of the growth-promoting receptor ICOS. Blood. 2011;118:3062-71 pubmed publisher
    ..lymphoma cells carrying the NPM-ALK fusion protein (ALK(+) TCL) frequently express the cell-stimulatory receptor ICOS. ICOS expression in ALK(+) TCL is moderate and strictly dependent on the expression and enzymatic activity of NPM-..
  8. Hutloff A, Dittrich A, Beier K, Eljaschewitsch B, Kraft R, Anagnostopoulos I, et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature. 1999;397:263-6 pubmed
    ..Here we report the identification of a third member of this family of molecules, inducible co-stimulator (ICOS), which is a homodimeric protein of relative molecular mass 55,000-60,000 (M(r) 55K-60K)...
  9. Yoshinaga S, Whoriskey J, Khare S, Sarmiento U, Guo J, Horan T, et al. T-cell co-stimulation through B7RP-1 and ICOS. Nature. 1999;402:827-32 pubmed
    ..The receptor, which is related to CD28 and is the homologue of the human protein ICOS, is expressed on activated T cells and resting memory T cells...

More Information

Publications119 found, 100 shown here

  1. Aicher A, Hayden Ledbetter M, Brady W, Pezzutto A, Richter G, Magaletti D, et al. Characterization of human inducible costimulator ligand expression and function. J Immunol. 2000;164:4689-96 pubmed
    The inducible costimulator (ICOS) is the newest member of the CD28/CD152 receptor family involved in regulating T cell activation...
  2. Piras G, Monne M, Uras A, Palmas A, Murineddu M, Arru L, et al. Genetic analysis of the 2q33 region containing CD28-CTLA4-ICOS genes: association with non-Hodgkin's lymphoma. Br J Haematol. 2005;129:784-90 pubmed
    ..We analysed the 2q33 chromosomal region harbouring CD28, CTLA4 and ICOS genes, which are closely linked and have related functions in immune regulation, for association in 100 non-Hodgkin'..
  3. Ling V, Wu P, Finnerty H, Bean K, Spaulding V, Fouser L, et al. Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor. J Immunol. 2000;164:1653-7 pubmed
    ..Of the CD28, CTLA4, and ICOS fusion constructs tested, flow cytometric analysis demonstrated only mouse ICOS-IgG binding to mGL50 cell ..
  4. Haimila K, Turpeinen H, Alakulppi N, Kyllönen L, Salmela K, Partanen J. Association of genetic variation in inducible costimulator gene with outcome of kidney transplantation. Transplantation. 2009;87:393-6 pubmed publisher
    The closely-linked genes of CD28, cytotoxic T-lymphocyte associated antigen 4 (CTLA4), inducible costimulator (ICOS), and programmed cell death 1 on chromosome 2q encode costimulatory molecules, which are regulators of the T-cell activity...
  5. Tezuka K, Tsuji T, Hirano D, Tamatani T, Sakamaki K, Kobayashi Y, et al. Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family. Biochem Biophys Res Commun. 2000;276:335-45 pubmed
    ..mouse and human AILIM homologues and the predicted amino acid sequences were identical to those of the inducible costimulator ICOS/CRP-1, which belongs to the CD28/CTLA4 family...
  6. Takahashi N, Matsumoto K, Saito H, Nanki T, Miyasaka N, Kobata T, et al. Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. J Immunol. 2009;182:5515-27 pubmed publisher
    Interaction of ICOS with its ligand is essential for germinal center formation, T cell immune responses, and development of autoimmune diseases...
  7. Bouwhuis M, Gast A, Figl A, Eggermont A, Hemminki K, Schadendorf D, et al. Polymorphisms in the CD28/CTLA4/ICOS genes: role in malignant melanoma susceptibility and prognosis?. Cancer Immunol Immunother. 2010;59:303-12 pubmed publisher
    ..CD28, Cytotoxic T lymphocyte antigen 4 (CTLA4) and inducible costimulator (ICOS) molecules are important secondary signal molecules in the T lymphocyte activation...
  8. Wassink L, Vieira P, Smits H, Kingsbury G, Coyle A, Kapsenberg M, et al. ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells. J Immunol. 2004;173:1779-86 pubmed
    Previous mouse studies have shown that IL-4 increases the expression of ICOS on activated Th cells, resulting in enhanced ICOS expression on Th2 cells...
  9. Suwalska K, Pawlak E, Karabon L, Tomkiewicz A, Dobosz T, Urbaniak Kujda D, et al. Association studies of CTLA-4, CD28, and ICOS gene polymorphisms with B-cell chronic lymphocytic leukemia in the Polish population. Hum Immunol. 2008;69:193-201 pubmed publisher
    ..of the costimulatory molecules cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28, and inducible co-stimulator (ICOS) leads to disturbances of immune response and an increased risk of cancer...
  10. Wu J, Tang J, Wu S, Lio H, Yang Y. Functional polymorphism of CTLA-4 and ICOS genes in allogeneic hematopoietic stem cell transplantation. Clin Chim Acta. 2009;403:229-33 pubmed publisher
    ..Cytotoxic T lymphocyte antigen-4 (CTLA-4) and inducible costimulator (ICOS) are costimulatory molecules of T cell activation and their genetic variations can affect the ..
  11. Graves S, Rezvani A, Sale G, Stone D, Parker M, Rosinski S, et al. A Canine Model of Chronic Graft-versus-Host Disease. Biol Blood Marrow Transplant. 2017;23:420-427 pubmed publisher
    ..Peripheral blood lymphocyte surface antigen expression of CD28 and inducible costimulator was elevated in dogs with GHVD compared with those in normal dogs, but not significantly so...
  12. Malik K, He H, Huynh T, Tran G, Mueller K, Doytcheva K, et al. Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature. J Allergy Clin Immunol. 2019;143:604-618 pubmed publisher
    ..in a severity-related manner, patients with Netherton syndrome showed the greatest T-cell activation (inducible costimulator [ICOS]) and a broader immune phenotype with TH1/IFN-γ, OASL, and TH2/IL-4 receptor/..
  13. Sanmamed M, Pastor F, Rodriguez A, Perez Gracia J, Rodriguez Ruiz M, Jure Kunkel M, et al. Agonists of Co-stimulation in Cancer Immunotherapy Directed Against CD137, OX40, GITR, CD27, CD28, and ICOS. Semin Oncol. 2015;42:640-55 pubmed publisher
    ..or CD27 and others whose expression is induced upon recent previous antigen priming, ie, CD137, GITR, OX40, and ICOS. Ligation of these glycoproteins with agonist antibodies actively conveys activating signals to the lymphocyte...
  14. Jounai K, Ikado K, Sugimura T, Ano Y, Braun J, Fujiwara D. Spherical lactic acid bacteria activate plasmacytoid dendritic cells immunomodulatory function via TLR9-dependent crosstalk with myeloid dendritic cells. PLoS ONE. 2012;7:e32588 pubmed publisher
    ..L. lactis strains also stimulated expression of immunoregulatory receptors on pDC (ICOS-L and PD-L1), and accordingly augmented pDC induction of CD4(+)CD25(+)FoxP3(+) Treg compared to the Lactobacillus ..
  15. Cheng H, Tay S, Wen C, Lin C, Wang A, Shih L, et al. Bioimaging of alloantigen-stimulated regulatory T cells in rat vascularized composite allotransplantation. PLoS ONE. 2018;13:e0203624 pubmed publisher
    ..vivo migratory pattern coincided with the altered expression of cell surface molecules of CD62L, CD103, CD134, and CD278, following donor-antigen stimulation...
  16. Shibutani M, Maeda K, Nagahara H, Fukuoka T, Matsutani S, Kashiwagi S, et al. A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study. BMC Cancer. 2018;18:371 pubmed publisher
    ..cell death 1 (PD-1), cytotoxic T-lymphocyte-associated protein 4 (CTLA4), inducible T-cell co-stimulator (ICOS), Glucocorticoid induced tumor necrosis factor receptor related protein (GITR), Human Leukocyte Antigen - antigen D ..
  17. Kozela E, Juknat A, Kaushansky N, Ben Nun A, Coppola G, Vogel Z. Cannabidiol, a non-psychoactive cannabinoid, leads to EGR2-dependent anergy in activated encephalitogenic T cells. J Neuroinflammation. 2015;12:52 pubmed publisher
    ..factor), and LAG3 mRNAs, as well as of several enhancers of cell cycle arrest (such as Nfatc1, Casp4, Cdkn1a, and Icos)...
  18. Tai Y, Sakamoto K, Takano A, Haga K, Harada Y. Dysregulation of humoral immunity in Foxp3 conditional-knockout mice. Biochem Biophys Res Commun. 2019;: pubmed publisher
    ..mice had increased expression of several activation markers, including inducible costimulator and CD40 ligand, as well as the cytokines interleukin 4 and interferon gamma...
  19. Lee S, Moon S, Kim E, Seo H, Yang E, Son H, et al. Metformin Suppresses Systemic Autoimmunity in Roquinsan/san Mice through Inhibiting B Cell Differentiation into Plasma Cells via Regulation of AMPK/mTOR/STAT3. J Immunol. 2017;198:2661-2670 pubmed publisher
    ..A significant reduction in ICOS+ follicular helper T cells was found in the spleens of the metformin-treated group compared with the ..
  20. Aljurayyan A, Puksuriwong S, Ahmed M, Sharma R, Krishnan M, Sood S, et al. Activation and Induction of Antigen-Specific T Follicular Helper Cells Play a Critical Role in Live-Attenuated Influenza Vaccine-Induced Human Mucosal Anti-influenza Antibody Response. J Virol. 2018;92: pubmed publisher
    ..LAIV-induced TFH differentiation was inhibited by BCL6, interleukin-21 (IL-21), ICOS, and CD40 signaling blocking, and that diminished anti-HA antibody production...
  21. Guttman Yassky E, Bissonnette R, Ungar B, Suárez Fariñas M, Ardeleanu M, Esaki H, et al. Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis. J Allergy Clin Immunol. 2019;143:155-172 pubmed publisher
    ..IL31, CCL17, CCL18, and CCL26), epidermal hyperplasia (keratin 16 [K16] and MKi67), T cells, dendritic cells (ICOS, CD11c, and CTLA4), and TH17/TH22 activity (IL17A, IL-22, and S100As) and concurrently ..
  22. Dai K, Huang L, Sun X, Yang L, Gong Z. Hepatic CD206-positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection. J Leukoc Biol. 2015;98:1071-80 pubmed publisher
    ..the immunosuppressive activity of intrahepatic regulatory T cells, demonstrated by higher expression of CTLA-4, ICOS, and CD39, as well as stronger inhibition of antiviral function of CD8(+) T cells...
  23. Shimosaki S, Nakahata S, Ichikawa T, Kitanaka A, Kameda T, Hidaka T, et al. Development of a complete human IgG monoclonal antibody to transferrin receptor 1 targeted for adult T-cell leukemia/lymphoma. Biochem Biophys Res Commun. 2017;485:144-151 pubmed publisher
    ..Therefore, we developed human IgG monoclonal antibodies to human TFR1 using a phage display method (ICOS method) to block the incorporation of the transferrin (TF)-iron complex into ATLL cells for inhibiting cell growth...
  24. Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, et al. Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target. PLoS ONE. 2014;9:e107490 pubmed publisher
    ..mice had an impaired ability to secrete Th2 cytokines in response to anti-CD3 stimulation whilst the expression of ICOS was not significantly different to wild type...
  25. Tsai H, Wu C, Chen Y, Liao H, Chyuan I, Hsu P. Galectin-3 suppresses mucosal inflammation and reduces disease severity in experimental colitis. J Mol Med (Berl). 2016;94:545-56 pubmed publisher
    ..In addition, primary T cells treated with galectin-3 ex vivo induced the expression of FOXP3, ICOS, and PD-1 with a Treg cell phenotype having a suppression function...
  26. Tousa S, Semitekolou M, Morianos I, Banos A, Trochoutsou A, Brodie T, et al. Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses. Proc Natl Acad Sci U S A. 2017;114:E2891-E2900 pubmed publisher
    ..of CD4+ T cells that express the Tr1-cell-associated molecules IL-10, inducible T-Cell costimulator (ICOS), lymphocyte activation gene 3 protein (LAG-3), and CD49b, and exert strongly suppressive functions toward allergic ..
  27. Heim L, Friedrich J, Engelhardt M, Trufa D, Geppert C, Rieker R, et al. NFATc1 Promotes Antitumoral Effector Functions and Memory CD8+ T-cell Differentiation during Non-Small Cell Lung Cancer Development. Cancer Res. 2018;78:3619-3633 pubmed publisher
    ..In CD4+ICOS+ T cells, programmed cell death 1 (PD-1) was induced in the draining lymph nodes of these mice and ..
  28. Li B, Stadhouders R, de Bruijn M, Lukkes M, Beerens D, Brem M, et al. Group 2 Innate Lymphoid Cells Exhibit a Dynamic Phenotype in Allergic Airway Inflammation. Front Immunol. 2017;8:1684 pubmed publisher
    ..IL-33-activated BAL fluid ILC2s exhibited an almost uniform CD25+CD127+T1/ST2+ICOS+KLRG1+ phenotype, at a comparable time point after HDM exposure BAL fluid ILC2s had a very ..
  29. Zheng R, Chen F, Gao W, Wang D, Yang Q, Wang K, et al. The TH2-polarizing function of atopic interleukin 17 receptor B-positive dendritic cells up-regulated by lipopolysaccharide. Ann Allergy Asthma Immunol. 2017;118:474-482.e1 pubmed publisher
    ..In addition, LPS increased the expression of the OX40 ligand (OX40L) but decreased inducible costimulator ligand on atopic CD86+ mo-DCs...
  30. Deist M, Gallardo R, Bunn D, Kelly T, Dekkers J, Zhou H, et al. Novel Mechanisms Revealed in the Trachea Transcriptome of Resistant and Susceptible Chicken Lines following Infection with Newcastle Disease Virus. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..The pathways conserved across lines and at all three time points postinfection included iCOS-iCOSL signaling in T helper cells, NF-?B signaling, the role of nuclear factor of activated T cells in the ..
  31. Kawamoto M, Harigai M, Hara M, Kawaguchi Y, Tezuka K, Tanaka M, et al. Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production. Arthritis Res Ther. 2006;8:R62 pubmed
    Inducible co-stimulator (ICOS) is the third member of the CD28/cytotoxic T-lymphocyte associated antigen-4 family and is involved in the proliferation and activation of T cells...
  32. Butty V, Roy M, Sabeti P, Besse W, Benoist C, Mathis D. Signatures of strong population differentiation shape extended haplotypes across the human CD28, CTLA4, and ICOS costimulatory genes. Proc Natl Acad Sci U S A. 2007;104:570-5 pubmed
    The three members of the costimulatory receptor family, CD28, CTLA-4, and ICOS, have complementary effects on T cell activation, and their balance controls the overall outcome of immune and autoimmune responses...
  33. Franko J, Levine A. Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner. J Leukoc Biol. 2009;85:526-38 pubmed publisher
    Engagement of the costimulatory protein ICOS activates effector/memory T cells in tissue by enhancing TCR-mediated proliferation and cytokine production...
  34. Li W, Pan H, Chen G, Tao J, Li X, Ye D. Expression of inducible co-stimulator on peripheral blood T lymphocytes in patients with lupus nephritis. Rheumatol Int. 2012;32:2051-5 pubmed publisher
    ..Studies have shown that elevated inducible co-stimulator (ICOS) in SLE. The purpose of the study was to investigate the expression of ICOS on T cells in patients with LN...
  35. FABIAN C. Prevention and Treatment of Cardiac Dysfunction in Breast Cancer Survivors. Adv Exp Med Biol. 2015;862:213-30 pubmed publisher
    ..are likely best achieved by partnerships between cardiologists, oncologists and internists such as those initiated with the formation of the International CardiOncology Society (ICOS) and the NCI Community Cardiotoxicity Task Force.
  36. Czarnowicki T, Esaki H, Gonzalez J, Malajian D, Shemer A, Noda S, et al. Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)(+) TH2/TH1 cell imbalance, whereas adults acquire CLA(+) TH22/TC22 cell subsets. J Allergy Clin Immunol. 2015;136:941-951.e3 pubmed publisher
    ..Flow cytometry was used to measure CD69/inducible costimulator/HLA-DR frequency in memory cell subsets, as well as IFN-γ, IL-13, IL-9, IL-17, and IL-22 cytokines, ..
  37. Zamarin D, Holmgaard R, Ricca J, Plitt T, Palese P, Sharma P, et al. Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity. Nat Commun. 2017;8:14340 pubmed publisher
    ..innate immunity, upregulates the expression of T-cell co-stimulatory receptors, with the inducible co-stimulator (ICOS) being most notable...
  38. Liu Z, Ravindranathan R, Kalinski P, Guo Z, Bartlett D. Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy. Nat Commun. 2017;8:14754 pubmed publisher
    ..non-redundant tumour infiltration of effector CD8+, CD4+ T cells, with increased IFN-γ, ICOS, granzyme B and perforin expression...
  39. Arbour K, Naidoo J, Steele K, Ni A, Moreira A, Rekhtman N, et al. Expression of PD-L1 and other immunotherapeutic targets in thymic epithelial tumors. PLoS ONE. 2017;12:e0182665 pubmed publisher
    ..membranous PD-L1 on tumor cells, CD3+ and CD8+ tumor infiltrating lymphocytes (TILs), co-stimulatory (CD137, GITR, ICOS), and co-inhibitory immune checkpoint molecules (PD-1, CTLA-4, TIM-3) were assessed semi-quantitatively using ..
  40. Quiroga M, Pasquinelli V, Martinez G, Jurado J, Zorrilla L, Musella R, et al. Inducible costimulator: a modulator of IFN-gamma production in human tuberculosis. J Immunol. 2006;176:5965-74 pubmed
    ..We investigated the regulated expression and functional role of the inducible costimulator (ICOS), a receptor known to regulate Th cytokine production, in the context of human tuberculosis...
  41. Li J, Heinrichs J, Leconte J, Haarberg K, Semple K, Liu C, et al. Phosphatidylinositol 3-kinase-independent signaling pathways contribute to ICOS-mediated T cell costimulation in acute graft-versus-host disease in mice. J Immunol. 2013;191:200-7 pubmed publisher
    We and others have previously shown that ICOS plays an important role in inducing acute graft-versus-host disease (GVHD) in murine models of allogeneic bone marrow transplantation...
  42. Ramakrishna V, Sundarapandiyan K, Zhao B, Bylesjo M, Marsh H, Keler T. Characterization of the human T cell response to in vitro CD27 costimulation with varlilumab. J Immunother Cancer. 2015;3:37 pubmed publisher
    ..Activation was accompanied by upregulated cell surface expression of costimulatory [4-1BB, OX40, GITR and ICOS] and coinhibitory [PD-1] molecules...
  43. Rhodes D, Reith W, Trowsdale J. Regulation of Immunity by Butyrophilins. Annu Rev Immunol. 2016;34:151-72 pubmed publisher
    ..1 (CD80), B7.2 (CD86), and related molecules, such as PD-L1 (B7-H1, CD274), ICOS-L (CD275), and B7-H3 (CD276)...
  44. Hu X, Liu C, An J, Shen Y, Hu Y, Jiang J, et al. Development of a Novel Functional Monoclonal Antibody to Human CD275: Characterization and Biological Activity. Monoclon Antib Immunodiagn Immunother. 2016;35:18-24 pubmed publisher
    ..the antibody recognized different epitopes of CD275 antigen compared with commercial antibodies and could block ICOS-CD275 interaction...
  45. Yi J, Ready N, Healy P, Dumbauld C, Osborne R, Berry M, et al. Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus Ipilimumab. Clin Cancer Res. 2017;23:7474-7482 pubmed publisher
    ..Significant increases in the frequencies of CD4+ cells expressing activation markers ICOS, HLA-DR, CTLA-4, and PD-1 were apparent...
  46. Jayaraman A, Sharma M, Prabhakar B, Holterman M, Jayaraman S. Amelioration of progressive autoimmune encephalomyelitis by epigenetic regulation involves selective repression of mature neutrophils during the preclinical phase. Exp Neurol. 2018;304:14-20 pubmed publisher
    ..Interestingly, the co-inhibitory ligand CD274+ (PD-L1+) but not CD275+ (ICOS-L+), CD39+ or CD11c+ dendritic cells were decreased in the peripheral lymphoid ..
  47. Athanasopoulos V, Barker A, Yu D, Tan A, Srivastava M, Contreras N, et al. The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. FEBS J. 2010;277:2109-27 pubmed publisher
    ..but essential role in preventing T-cell-mediated autoimmune disease and in microRNA-mediated repression of inducible costimulator (Icos) mRNA...
  48. Matsui K, Adelsberger J, Kemp T, Baseler M, Ledgerwood J, Pinto L. Circulating CXCR5⁺CD4⁺ T Follicular-Like Helper Cell and Memory B Cell Responses to Human Papillomavirus Vaccines. PLoS ONE. 2015;10:e0137195 pubmed publisher
    ..Using CXCR5, CXCR3, CCR6, CCR7, PD1, and ICOS as markers, Tfh-like cells can be identified in the circulation and be classified into three functionally distinct ..
  49. Li J, Lu E, Yi T, Cyster J. EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells. Nature. 2016;533:110-4 pubmed publisher
    ..they interact with activated dendritic cells and are exposed to Tfh-cell-promoting inducible co-stimulator (ICOS) ligand...
  50. Shan Y, Qi C, Liu Y, Gao H, Zhao D, Jiang Y. Increased frequency of peripheral blood follicular helper T cells and elevated serum IL?21 levels in patients with knee osteoarthritis. Mol Med Rep. 2017;15:1095-1102 pubmed publisher
    ..Frequency of peripheral blood inducible costimulator (ICOS)+, programmed death 1 (PD?1)+, and IL?21+ CXCR5+CD4+ T cells in 40 patients with OA and 13 ..
  51. Friedlander P, Wassmann K, Christenfeld A, Fisher D, Kyi C, Kirkwood J, et al. Whole-blood RNA transcript-based models can predict clinical response in two large independent clinical studies of patients with advanced melanoma treated with the checkpoint inhibitor, tremelimumab. J Immunother Cancer. 2017;5:67 pubmed publisher
    ..A 15-gene pre-treatment classifier model (containing ADAM17, CDK2, CDKN2A, DPP4, ERBB2, HLA-DRA, ICOS, ITGA4, LARGE, MYC, NAB2, NRAS, RHOC, TGFB1, and TIMP1) achieved an area under the curve (AUC) of 0...
  52. Wang Y, Lin C, Cao Y, Duan Z, Guan Z, Xu J, et al. Up-regulation of Interleukin-21 Contributes to Liver Pathology of Schistosomiasis by Driving GC Immune Responses and Activating HSCs in Mice. Sci Rep. 2017;7:16682 pubmed publisher
    ..mouse model, we studied the dynamics and effects of Tfh cells in vivo and demonstrated that Tfh phenotype molecules ICOS, PD-1 and functional factor IL-21 were positively correlated with disease development by flow cytometry...
  53. Haimila K, Partanen J, Holopainen P. Genetic polymorphism of the human ICOS gene. Immunogenetics. 2002;53:1028-32 pubmed
    b>Inducible costimulator (ICOS) is a novel receptor belonging to the same family as CD28 and CTLA4, which regulate T-lymphocyte activation in the immune response...
  54. Fos C, Salles A, Lang V, Carrette F, Audebert S, Pastor S, et al. ICOS ligation recruits the p50alpha PI3K regulatory subunit to the immunological synapse. J Immunol. 2008;181:1969-77 pubmed
    b>ICOS ligation in concert with TCR stimulation results in strong PI3K activation in T lymphocytes...
  55. Hu J, Li Q, Hou S, Peng H, Guo J. Association of Inducible T Cell Costimulator Polymorphisms with Susceptibility and Outcome of Hepatitis B Virus Infection in a Chinese Han Population. Scand J Immunol. 2015;82:275-81 pubmed publisher
    b>Inducible T cell costimulator (ICOS) functions to regulate cell-cell signalling, immune responses and cell proliferation. ICOS single nucleotide polymorphism (SNP) may affect protein expression and functions...
  56. Ma C, Wong N, Rao G, Avery D, Torpy J, Hambridge T, et al. Monogenic mutations differentially affect the quantity and quality of T follicular helper cells in patients with human primary immunodeficiencies. J Allergy Clin Immunol. 2015;136:993-1006.e1 pubmed publisher
    ..with PIDs resulting from mutations in STAT3, STAT1, TYK2, IL21, IL21R, IL10R, IFNGR1/2, IL12RB1, CD40LG, NEMO, ICOS, or BTK. Loss-of-function (LOF) mutations in STAT3, IL10R, CD40LG, NEMO, ICOS, or BTK reduced cTFH cell frequencies...
  57. Zhang Z, Zhang W, Guo J, Gu Q, Zhu X, Zhou X. Activation and Functional Specialization of Regulatory T Cells Lead to the Generation of Foxp3 Instability. J Immunol. 2017;198:2612-2625 pubmed publisher
    ..We further demonstrated that the signal switch from IL-2 to ICOS during Treg activation induced Treg instability and reprogramming...
  58. Zheng Z, Xu P, Wang L, Zhao H, Weng X, Zhong H, et al. MiR21 sensitized B-lymphoma cells to ABT-199 via ICOS/ICOSL-mediated interaction of Treg cells with endothelial cells. J Exp Clin Cancer Res. 2017;36:82 pubmed publisher
    ..of Bcl-2positive and Bcl-2negative B-lymphoma cells, miR21 induced inducible co-stimulator (ICOS) expression on regulatory T (Treg) cells...
  59. Tsai A, Khan A, Worgo C, Wang L, Liang Y, Davila E. A Multikinase and DNA-PK Inhibitor Combination Immunomodulates Melanomas, Suppresses Tumor Progression, and Enhances Immunotherapies. Cancer Immunol Res. 2017;5:790-803 pubmed publisher
    ..and exhibited a favorably altered phenotype, including increased CD25, CD28, inducible T-cell costimulator (ICOS), and reduced expression of coinhibitory receptors. Cytokine production was also increased in treated T cells...
  60. Guzman V, Yambartsev A, Goncalves Primo A, Silva I, Carvalho C, Ribalta J, et al. New approach reveals CD28 and IFNG gene interaction in the susceptibility to cervical cancer. Hum Mol Genet. 2008;17:1838-44 pubmed publisher
    ..A total of 14 single nucleotide polymorphisms (SNPs) distributed in CD28, CTLA4, ICOS, PDCD1, FAS, TNFA, IL6, IFNG, TGFB1 and IL10 genes were determined in patients and healthy individuals from three ..
  61. Buus T, Schmidt J, Bonefeld C, Geisler C, Lauritsen J. Development of interleukin-17-producing V?2+ ?? T cells is reduced by ICOS signaling in the thymus. Oncotarget. 2016;7:19341-54 pubmed publisher
    ..In this study, we have investigated the role of inducible T cell co-stimulator (ICOS) on the development of ?? T cells...
  62. Mahne A, Mauze S, Joyce Shaikh B, Xia J, Bowman E, Beebe A, et al. Dual Roles for Regulatory T-cell Depletion and Costimulatory Signaling in Agonistic GITR Targeting for Tumor Immunotherapy. Cancer Res. 2017;77:1108-1118 pubmed publisher
    ..persisting Tregs following anti-GITR mAb treatment showed that a highly activated subpopulation of CD44hiICOShi intratumoral Tregs were preferentially targeted for elimination, with the remaining Tregs exhibiting a ..
  63. Shalaby K, Al Heialy S, Tsuchiya K, Farahnak S, McGovern T, Risse P, et al. The TLR4-TRIF pathway can protect against the development of experimental allergic asthma. Immunology. 2017;152:138-149 pubmed publisher
    ..role of these adaptors in the TLR4-dependent inhibition of allergic airway disease and induction of CD4+ ICOS+ T cells by nasal application of Protollin™, a mucosal adjuvant composed of TLR2 and TLR4 agonists...
  64. Lownik J, Luker A, Damle S, Cooley L, El Sayed R, Hutloff A, et al. ADAM10-Mediated ICOS Ligand Shedding on B Cells Is Necessary for Proper T Cell ICOS Regulation and T Follicular Helper Responses. J Immunol. 2017;199:2305-2315 pubmed publisher
    The proper regulation of ICOS and ICOS ligand (ICOSL) has been shown to be essential for maintaining proper immune homeostasis...
  65. Wilson P, Larminie C, Smith R. Literature mining, gene-set enrichment and pathway analysis for target identification in Behçet's disease. Clin Exp Rheumatol. 2016;34:101-110 pubmed
    ..Computational methods have captured pertinent features of the prominent disease characteristics presented in Behçet's disease and have highlighted NOD2, ICOS and IL18 signalling as potential therapeutic strategies.
  66. Xerri L, Huet S, Venstrom J, Szafer Glusman E, Fabiani B, Canioni D, et al. Rituximab treatment circumvents the prognostic impact of tumor-infiltrating T-cells in follicular lymphoma patients. Hum Pathol. 2017;64:128-136 pubmed publisher
    ..was quantified using automated image analysis in 417, 287, 418, 406, 379, and 369 patients for CD3, CD4, CD8, PD1, ICOS, and FOXP3, respectively. RNAseq analysis was used to quantify TIL-related mRNA transcripts from 148 patients...
  67. Marafioti T, Paterson J, Ballabio E, Chott A, Natkunam Y, Rodriguez Justo M, et al. The inducible T-cell co-stimulator molecule is expressed on subsets of T cells and is a new marker of lymphomas of T follicular helper cell-derivation. Haematologica. 2010;95:432-9 pubmed publisher
    ..In the present study the expression pattern of ICOS protein was investigated by immunohistochemistry-based techniques in routine sections of normal lymphoid tissues ..
  68. Torres Martínez M, Rubio Infante N, García Hernández A, Nava Acosta R, Ilhuicatzi Alvarado D, Moreno Fierros L. Cry1Ac toxin induces macrophage activation via ERK1/2, JNK and p38 mitogen-activated protein kinases. Int J Biochem Cell Biol. 2016;78:106-115 pubmed publisher
    ..7 macrophages with the Cry1Ac toxin resulted in upregulation of the costimulatory molecules CD80, CD86 and ICOS-L and enhanced production of nitric oxide, the chemokine MCP-1 and the proinflammatory cytokines TNF-? and IL-6...
  69. Sim G, Liu C, Wang E, Liu H, Creasy C, Dai Z, et al. IL2 Variant Circumvents ICOS+ Regulatory T-cell Expansion and Promotes NK Cell Activation. Cancer Immunol Res. 2016;4:983-994 pubmed
    ..to selective expansion of CD4+CD25+Foxp3+ T-regulatory cells (Treg), especially ICOS+ Tregs, rather than natural killer (NK) cells and effector T cells...
  70. Beider K, Naor D, Voevoda V, Ostrovsky O, Bitner H, Rosenberg E, et al. Dissecting the mechanisms involved in anti-human T-lymphocyte immunoglobulin (ATG)-induced tolerance in the setting of allogeneic stem cell transplantation - potential implications for graft versus host disease. Oncotarget. 2017;8:90748-90765 pubmed publisher
    ..Phenotypic characterization revealed a significant increase in the expression of FoxP3, GITR, CD95, PD-1 and ICOS as well as the complement inhibitory molecules CD55, CD58 and CD59 on CD4+CD25+ T cells upon ATG treatment...
  71. Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat Immunol. 2003;4:261-8 pubmed
    ..In a search for CVID candidate proteins, we found four of 32 patients to lack ICOS, the "inducible costimulator" on activated T cells, due to an inherited homozygous deletion in the ICOS gene...
  72. Kämmerer P, Toyoshima T, Schöder F, Kämmerer P, Kuhr K, Brieger J, et al. Association of T-cell regulatory gene polymorphisms with oral squamous cell carcinoma. Oral Oncol. 2010;46:543-8 pubmed publisher
    ..aim of this study was to determine the relevance of cytotoxic T-lymphocyte antigen 4 (CTLA-4), CD28 and inducible costimulator (ICOS) polymorphisms in oral squamous cell carcinoma (OSCC)...
  73. Ferreira M, Zhao Z, Thomsen S, James M, Evans D, Postmus P, et al. Association and interaction analyses of eight genes under asthma linkage peaks. Allergy. 2009;64:1623-8 pubmed publisher
    ..Ninety-five single nucleotide polymorphisms (SNP) located in eight genes (CD28, CTLA4, ICOS, ADAM23, ADAMTSL1, MS4A2, CDH26 and HRH3) were genotyped in >5000 individuals from Australian (n = 1162), Dutch (..
  74. Karabon L, Pawlak E, Tomkiewicz A, Jedynak A, Passowicz Muszyńska E, Zajda K, et al. CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer. Hum Immunol. 2011;72:947-54 pubmed publisher
    Polymorphisms in genes encoding CD28, ICOS, and CTLA-4 were demonstrated to be associated with susceptibility to malignancies...
  75. Tahiliani V, Hutchinson T, Abboud G, Croft M, Salek Ardakani S. OX40 Cooperates with ICOS To Amplify Follicular Th Cell Development and Germinal Center Reactions during Infection. J Immunol. 2017;198:218-228 pubmed
    ..Whereas costimulatory receptors such as ICOS are accepted as being important for the induction of Tfh cell fate decision, other molecules may play key roles in ..
  76. Kovaleva M, Johnson K, Steven J, Barelle C, Porter A. Therapeutic Potential of Shark Anti-ICOSL VNAR Domains is Exemplified in a Murine Model of Autoimmune Non-Infectious Uveitis. Front Immunol. 2017;8:1121 pubmed publisher
    ..ligand (ICOSL) plays an important role in the activation of T cells through its interaction with the inducible costimulator, ICOS...
  77. Rehage N, Davydova E, Conrad C, Behrens G, Maiser A, Stehklein J, et al. Binding of NUFIP2 to Roquin promotes recognition and regulation of ICOS mRNA. Nat Commun. 2018;9:299 pubmed publisher
    ..Post-transcriptional repression of human ICOS by endogenous Roquin proteins requires two neighboring non-canonical stem-loops in the ICOS 3'-UTR...
  78. Riley J, Mao M, Kobayashi S, Biery M, Burchard J, Cavet G, et al. Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors. Proc Natl Acad Sci U S A. 2002;99:11790-5 pubmed
    ..CD28 and ICOS costimulation had nearly identical effects on gene regulation, but a few transcripts (e.g...
  79. Flesch I. Inducible costimulator (ICOS). J Biol Regul Homeost Agents. 2002;16:214-6 pubmed
  80. Akalin E, Dikman S, Murphy B, Bromberg J, Hancock W. Glomerular infiltration by CXCR3+ ICOS+ activated T cells in chronic allograft nephropathy with transplant glomerulopathy. Am J Transplant. 2003;3:1116-20 pubmed
    ..Immunohistologic analysis of human renal transplant biopsies showed expression of inducible costimulator (ICOS), the chemokine receptor CXCR3, and its ligands, Mig and IP-10, by intraglomerular and ..
  81. Mo L, Chen Q, Zhang X, Shi X, Wei L, Zheng D, et al. Depletion of regulatory T cells by anti-ICOS antibody enhances anti-tumor immunity of tumor cell vaccine in prostate cancer. Vaccine. 2017;35:5932-5938 pubmed publisher
    b>ICOS+Treg cells exert important immunosuppressive effects in tumor immunity...
  82. Hu W, Janke A, Ortler S, Hartung H, Leder C, Kieseier B, et al. Expression of CD28-related costimulatory molecule and its ligand in inflammatory neuropathies. Neurology. 2007;68:277-82 pubmed
    ..To analyze the expression and distribution pattern of the inducible costimulator (ICOS), a recently identified costimulatory molecule implicated in T-cell activation, and its unique ..
  83. Figueiredo M, Costa P, Diniz S, Henriques P, Kano F, Tada M, et al. T follicular helper cells regulate the activation of B lymphocytes and antibody production during Plasmodium vivax infection. PLoS Pathog. 2017;13:e1006484 pubmed publisher
    ..vivax malaria. We demonstrate that P. vivax infection triggers IL-21 production and an increase in Tfh cells (PD-1+ICOS+CXCR5+CD45RO+CD4+CD3+)...
  84. Lee Y, Ji J, Sohn J, Song G. Polymorphsims of CTLA-4 exon 1 +49, CTLA-4 promoter -318 and Fas promoter -670 in spondyloarthropathies. Clin Rheumatol. 2001;20:420-2 pubmed
    ..However, further studies are required to discover the possible contribution of the polymorphisms of the CTLA-4 and Fas to the pathogenesis of SpA. ..
  85. Karunarathne D, Horne Debets J, Huang J, Faleiro R, Leow C, Amante F, et al. Programmed Death-1 Ligand 2-Mediated Regulation of the PD-L1 to PD-1 Axis Is Essential for Establishing CD4(+) T Cell Immunity. Immunity. 2016;45:333-45 pubmed publisher
    ..malaria, because it not only inhibited PD-L1 to PD-1 activity but also increased CD3 and inducible co-stimulator (ICOS) expression on T cells...
  86. Ammitzbøll C, Börnsen L, Romme Christensen J, Ratzer R, Romme Nielsen B, Søndergaard H, et al. Smoking reduces circulating CD26hiCD161hi MAIT cells in healthy individuals and patients with multiple sclerosis. J Leukoc Biol. 2017;101:1211-1220 pubmed publisher
    ..differences were seen in plasmacytoid dendritic cells (pDCs) and CD8+ T cells as higher percentages of ICOS ligand (ICOSL)+ pDCs and lower percentages of CD26hiCD161hi CD8+ T ..
  87. Alakulppi N, Kyllönen L, Partanen J, Salmela K, Laine J. Diagnosis of acute renal allograft rejection by analyzing whole blood mRNA expression of lymphocyte marker molecules. Transplantation. 2007;83:791-8 pubmed
    ..The mRNA expression of granzyme B, perforin, FasL, granulysin, CD154, ICOS, CTLA4 and PD-1 were analyzed with real-time quantitative polymerase chain reaction...
  88. Douroudis K, Laine A, Heinonen M, Hermann R, Lipponen K, Veijola R, et al. Association of CTLA4 but not ICOS polymorphisms with type 1 diabetes in two populations with different disease rates. Hum Immunol. 2009;70:536-9 pubmed publisher
    Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases...
  89. Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, et al. Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature. 2010;466:113-7 pubmed publisher
    ..We have defined the genetic underpinnings of AA, placing it within the context of shared pathways among autoimmune diseases, and implicating a novel disease mechanism, the upregulation of ULBP ligands, in triggering autoimmunity. ..
  90. Wang D, Zhou D, Du Q, Liang Q, Wang Q, Fang L, et al. Aberrant production of soluble inducible T-cell co-stimulator (sICOS) and soluble programmed cell death protein 1 (sPD-1) in patients with chronic hepatitis C. Mol Med Rep. 2013;7:1197-202 pubmed publisher
    ..Co?stimulation signals, including programmed cell death protein 1 (PD?1) and inducible T?cell co?stimulator (ICOS), have been demonstrated to be involved in the pathogenesis of HCV...
  91. Wang L, Sun X, Qiu J, Cai Y, Ma L, Zhao P, et al. Increased numbers of circulating ICOS⁺ follicular helper T and CD38⁺ plasma cells in patients with newly diagnosed primary biliary cirrhosis. Dig Dis Sci. 2015;60:405-13 pubmed publisher
    ..The numbers of circulating CD27(+), CD38(+), CD86(+) and CD95(+) B cells as well as inducible T cell costimulator (ICOS)(+) and programmed death-1 (PD-1)(+), IL-21(+) TFH cells were examined in 58 patients with newly ..