Gene Symbol: ICAT
Description: catenin beta interacting protein 1
Alias: ICAT, beta-catenin-interacting protein 1, beta-catenin-interacting protein ICAT, inhibitor of beta-catenin and Tcf-4
Species: human
Products:     ICAT

Top Publications

  1. Graham T, Clements W, Kimelman D, Xu W. The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. Mol Cell. 2002;10:563-71 pubmed
    ..We have determined the crystal structure at 2.5 A resolution of a complex between beta-catenin and ICAT, a protein that prevents the interaction between beta-catenin and Tcf/Lef family transcription factors...
  2. Koyama T, Tago K, Nakamura T, Ohwada S, Morishita Y, Yokota J, et al. Mutation and expression of the beta-catenin-interacting protein ICAT in human colorectal tumors. Jpn J Clin Oncol. 2002;32:358-62 pubmed
    ..We have recently identified the ICAT gene, which encodes a small protein that interacts with beta-catenin and represses Wnt signaling...
  3. Gottardi C, Gumbiner B. Role for ICAT in beta-catenin-dependent nuclear signaling and cadherin functions. Am J Physiol Cell Physiol. 2004;286:C747-56 pubmed
    Inhibitor of beta-catenin and TCF-4 (ICAT) is a 9-kDa polypeptide that inhibits beta-catenin nuclear signaling by binding beta-catenin and competing its interaction with the transcription factor TCF (T cell factor), but basic ..
  4. Deng Z, Niu G, Cai L, Wei R, Zhao X. The prognostic significance of CD44V6, CDH11, and ?-catenin expression in patients with osteosarcoma. Biomed Res Int. 2013;2013:496193 pubmed publisher
    ..Thus, our results indicated abnormal expression of CD44V6, CDH11, and ?-catenin in osteosarcomas and osteochondromas, which may provide important indicators for further research...
  5. Song L, Feng L, Guo Y. Hydrophilic quaternary ammonium-group-containing [FeFe]H2ase models prepared by quaternization of the pyridyl N atoms in pyridylazadiphosphine- and pyridylmethylazadiphosphine-bridged diiron complexes with various electrophiles. Dalton Trans. 2019;48:1443-1453 pubmed publisher
    ..In addition, the electrocatalytic study demonstrated that both 1 and 3 can serve as electrocatalysts for H2 production from acetic acid with higher icat/ip and TONs in MeCN/H2O than in MeCN.
  6. Morales Bárcenas R, Chirino Y, Sánchez Pérez Y, Osornio Vargas Ã, Melendez Zajgla J, Rosas I, et al. Particulate matter (PM₁₀) induces metalloprotease activity and invasion in airway epithelial cells. Toxicol Lett. 2015;237:167-73 pubmed publisher
    ..These in vitro findings are relevant in terms of the mechanism action of PM10 in lung epithelial cells, which could be helpful in understanding the pathogenesis of some human illness associated with highly polluted cities. ..
  7. Herve F, Ragolle I, Amarenco G, Viaene A, Guinet Lacoste A, Bonniaud V, et al. Assessment of Intermittent Self-Catheterization Procedures in Patients with Neurogenic Lower Urinary Tract Dysfunction: Dutch Translation and Validation of the Intermittent Catheterization Satisfaction Questionnaire, Intermittent Catheterization Acce. Urol Int. 2019;:1-6 pubmed publisher
    ..Catheterization Satisfaction Questionnaire (InCaSaQ), the Intermittent Catheterization Acceptance Test (ICAT), the Intermittent Self Catheterization Questionnaire (ISCQ) and the Intermittent Catheterization Difficulty ..
  8. Shin J, Shin Y, Oh S, Yang H, Yu W, Lee J, et al. MiR-29b controls fetal mouse neurogenesis by regulating ICAT-mediated Wnt/β-catenin signaling. Cell Death Dis. 2014;5:e1473 pubmed publisher
    ..accumulation in the nucleus, where it couples with T-cell factor (TCF), an association that is disrupted by ICAT (inhibitor of β-catenin and T cell factor)...
  9. Sandh G, Ramström M, Stensjö K. Analysis of the early heterocyst Cys-proteome in the multicellular cyanobacterium Nostoc punctiforme reveals novel insights into the division of labor within diazotrophic filaments. BMC Genomics. 2014;15:1064 pubmed publisher
    ..proteome of newly formed heterocysts, compared to N2-fixing filaments, using the cysteine-specific selective ICAT methodology. The data set defined a good quantitative accuracy of the ICAT reagent in complex protein samples...

More Information

Publications147 found, 100 shown here

  1. Wang T, Chen Z, Zhu Y, Pan Q, Liu Y, Qi X, et al. Inhibition of transient receptor potential channel 5 reverses 5-Fluorouracil resistance in human colorectal cancer cells. J Biol Chem. 2015;290:448-56 pubmed publisher
    ..Taken together, we demonstrated an essential role of TrpC5 in ABCB1 induction and drug resistance in human CRC cells via promoting nuclear β-catenin accumulation. ..
  2. Wang B, Hom G, Zhou S, Guo M, Li B, Yang J, et al. The oxidized thiol proteome in aging and cataractous mouse and human lens revealed by ICAT labeling. Aging Cell. 2017;16:244-261 pubmed publisher
    ..same approach to determine, in the same specimens, all the disulfide-forming noncrystallin proteins identified by ICAT proteomics...
  3. Jiang Y, Ren W, Wang W, Xia J, Gou L, Liu M, et al. Inhibitor of ?-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/?-catenin complex. Oncol Rep. 2017;38:2597-2606 pubmed publisher
    The inhibitor of ?-catenin and TCF (ICAT) blocks the binding of TCF to ?-catenin and has been demonstrated as a suppressor of the Wnt/?-catenin signaling pathway...
  4. Matono H, Oda Y, Nakamori M, Tamiya S, Yamamoto H, Yokoyama R, et al. Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors. Hum Pathol. 2008;39:1802-8 pubmed publisher
  5. Schussel J, Pinto D, Martins M. Altered β-catenin expression related to cancer progression on actinic cheilitis and squamous cell carcinoma of the lip. Ann Diagn Pathol. 2011;15:1-5 pubmed publisher
    ..Cytoplasmatic and nuclear staining of β-catenin on studied cases point to pathway alterations. Results demonstrated that β-catenin expression is altered on epithelial dysplasia, and it is related to degree of alterations. ..
  6. Maltsev V, Lakatta E. Numerical models based on a minimal set of sarcolemmal electrogenic proteins and an intracellular Ca(2+) clock generate robust, flexible, and energy-efficient cardiac pacemaking. J Mol Cell Cardiol. 2013;59:181-95 pubmed publisher
    ..Inclusion of If or ICaT decreased the flexibility, but increased the robustness of the models (a relatively larger number of sets did not ..
  7. Qi W, Chen J, Cheng X, Huang J, Xiang T, Li Q, et al. Targeting the Wnt-Regulatory Protein CTNNBIP1 by microRNA-214 Enhances the Stemness and Self-Renewal of Cancer Stem-Like Cells in Lung Adenocarcinomas. Stem Cells. 2015;33:3423-36 pubmed publisher
    ..The identification of this functional miR-214-CTNNBIP1 interaction that regulates self-renewal in CSLCs has the potential to direct the development of novel therapeutic strategies for LAC. ..
  8. Pike J, Xie B, Tan N, Sabado Liwag M, Orne A, Toilolo T, et al. Developing an Internet- and Mobile-Based System to Measure Cigarette Use Among Pacific Islanders: An Ecological Momentary Assessment Study. JMIR Mhealth Uhealth. 2016;4:e2 pubmed publisher
    ..mobile phone apps, the enhanced functionality offered by Internet-based Cell phone-optimized Assessment Techniques (ICAT), and the high survey completion rates exhibited by EMA studies that used electronic diaries...
  9. Wang W, Tang W, Qiu Z. Comparative proteomics analysis on differentiation of human promyelocytic leukemia HL-60 cells into granulocyte and monocyte lineages. Ai Zheng. 2009;28:117-21 pubmed
    ..The differentially expressed proteins were identified using PD-Quest software and analyzed by MOLDI-TOF MS. ICAT protein with differential expression was verified by reverse transcription-polymerase chain reaction (RT-PCR) and ..
  10. Xie N, Huang K, Lei Y, Ran Y, Huang C. Proteomics annotation of lipid rafts modified by virus infection. Comb Chem High Throughput Screen. 2012;15:253-65 pubmed
    ..electrophoresis (2D-PAGE), two-dimensional difference gel electrophoresis (2D-DIGE), isotope-coded affinity tags (ICAT), Proteolytic ¹?O Labeling, isotope Tags for Relative and Absolute Quantification (iTRAQ), Stable Isotope Labeling ..
  11. Campos M, Sánchez Arévalo Lobo V, Rodolosse A, Gottardi C, Mafficini A, Beghelli S, et al. ICAT is a novel Ptf1a interactor that regulates pancreatic acinar differentiation and displays altered expression in tumours. Biochem J. 2013;451:395-405 pubmed publisher
    ..Using yeast two-hybrid screening, we identified ICAT (inhibitor of ?-catenin and Tcf4) as a novel Ptf1a interactor...
  12. Thrul J, Kuntsche E. The impact of friends on young adults' drinking over the course of the evening--an event-level analysis. Addiction. 2015;110:619-26 pubmed publisher
    ..Participants used the internet-based cellphone-optimized assessment technique (ICAT) to complete a series of cellphone questionnaires every Thursday, Friday and Saturday evening over five weekends...
  13. Peixoto Neves D, Wang Q, Leal Cardoso J, Rossoni L, Jaggar J. Eugenol dilates mesenteric arteries and reduces systemic BP by activating endothelial cell TRPV4 channels. Br J Pharmacol. 2015;172:3484-94 pubmed publisher
    ..mesenteric arteries (size 200-300 μm) was measured using wire myography; non-selective cation currents (ICat ) were recorded in endothelial cells using patch clamp electrophysiology...
  14. Ji L, Lu B, Wang Z, Yang Z, Reece Hoyes J, Russ C, et al. Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction. Mol Cell. 2018;72:37-47.e4 pubmed publisher
    ..Through a CRISPR screen of β-catenin stability, we have identified ICAT, a polypeptide previously known to block β-catenin-TCF interaction, as a natural inhibitor of APC...
  15. Bi W, Huang J, Nie C, Liu B, He G, Han J, et al. CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of β-catenin pathway. J Exp Clin Cancer Res. 2018;37:275 pubmed publisher
    ..CircRNA_102171 overexpression promotes PTC progression through activating Wnt/β-catenin pathway in a CTNNBIP1-dependent way. ..
  16. Chahrour O, Cobice D, Malone J. Stable isotope labelling methods in mass spectrometry-based quantitative proteomics. J Pharm Biomed Anal. 2015;113:2-20 pubmed publisher
    ..Several different strategies involving stable isotopes label (ICAT, ICPL, IDBEST, iTRAQ, TMT, IPTL, SILAC), label-free statistical assessment approaches (MRM, SWATH) and absolute ..
  17. Shin J, Kim H, Rhyu I, Kee S. Axin is expressed in mitochondria and suppresses mitochondrial ATP synthesis in HeLa cells. Exp Cell Res. 2016;340:12-21 pubmed publisher
    ..using various inhibitors of Wnt signaling showed that the reduction in cellular ATP levels was weaker in cases of ICAT protein expression and treatment with iCRT3 or NSC668036 compared with XAV939 treatment, suggesting that XAV939 ..
  18. Ramkumar S, Fan X, Wang B, Yang S, Monnier V. Reactive cysteine residues in the oxidative dimerization and Cu2+ induced aggregation of human γD-crystallin: Implications for age-related cataract. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3595-3604 pubmed publisher
    ..In contrast to our recently published results using ICAT-labeling method, manual mining of the same database confirmed the specific involvement of Cys111 in disulfides with ..
  19. Thrul J, Kuntsche E. Interactions Between Drinking Motives and Friends in Predicting Young Adults' Alcohol Use. Prev Sci. 2016;17:626-35 pubmed publisher
    ..Using the Internet-based cell phone-optimized assessment technique (ICAT), 183 young adults (53.0 % female, mean age?=?23...
  20. Chen Y, Li Y, Xue J, Gong A, Yu G, Zhou A, et al. Wnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation. EMBO J. 2016;35:668-84 pubmed publisher
    ..Wnt target-gene promoter and activates the Wnt signaling pathway by protecting the β-catenin/TCF4 complex from ICAT inhibition...
  21. Kim S, Park C, Lee M, Kwon M, Jho E, Song W. Cyclin-dependent kinase 2 regulates the interaction of Axin with beta-catenin. Biochem Biophys Res Commun. 2004;317:478-83 pubmed
    ..This suggests that cyclin A/CDK2 is a negative regulator of beta-catenin-mediated signal transduction, which exerts its effects through phosphorylation of Axin. ..
  22. Liu X, Wang L, Zhao S, Ji X, Luo Y, Ling F. ?-Catenin overexpression in malignant glioma and its role in proliferation and apoptosis in glioblastma cells. Med Oncol. 2011;28:608-14 pubmed publisher
    ..Taken together, these results indicate that overexpression of ?-catenin may be an important contributing factor to glioma progression. ..
  23. Liang S, Xu Z, Xu X, Zhao X, Huang C, Wei Y. Quantitative proteomics for cancer biomarker discovery. Comb Chem High Throughput Screen. 2012;15:221-31 pubmed
    ..gel-based methods, stable isotope labeling with amino acids in cell culture (SILAC), isotope-coded affinity tag (ICAT), the isobaric tags for relative and absolute quantification (iTRAQ), ¹?O labeling, absolute quantitation and ..
  24. Liu C, Tu Y, Sun X, Jiang J, Jin X, Bo X, et al. Wnt/beta-Catenin pathway in human glioma: expression pattern and clinical/prognostic correlations. Clin Exp Med. 2011;11:105-12 pubmed publisher
    ..01, 0.007 and 0.005, respectively). These results provide convincing evidence that the Wnt/?-catenin pathway correlated closely with the progression of gliomas and might be a novel prognostic marker for this neoplasm. ..
  25. Chen Q, Yu L, Tsang P, Wei J, Song Y, Cheuk A, et al. Systematic proteome analysis identifies transcription factor YY1 as a direct target of miR-34a. J Proteome Res. 2011;10:479-87 pubmed publisher
    ..profiling on miR-34a treated neuroblastoma cells (IMR32) was performed using isotope-coded affinity tags (ICAT) and Affymetrix U133plus2 microarray, respectively...
  26. Petriz B, Franco O. Application of cutting-edge proteomics technologies for elucidating host-bacteria interactions. Adv Protein Chem Struct Biol. 2014;95:1-24 pubmed publisher
    ..as the advances of gel-free quantitative proteomic techniques, from metabolic and chemical labeling (SILAC, iTRAQ, ICAT, (16)O/(18)O, QconCAT) to nonlabeling (MS spectra counting and peak integration) strategies...
  27. Tan Z, Zheng H, Liu X, Zhang W, Zhu J, Wu G, et al. MicroRNA-1229 overexpression promotes cell proliferation and tumorigenicity and activates Wnt/?-catenin signaling in breast cancer. Oncotarget. 2016;7:24076-87 pubmed publisher
    ..polyposis coli (APC), glycogen synthase kinase-3? (GSK-3?), and inhibitor of ?-catenin and T cell factor (ICAT)...
  28. Pisitkun T, Bieniek J, Tchapyjnikov D, Wang G, Wu W, Shen R, et al. High-throughput identification of IMCD proteins using LC-MS/MS. Physiol Genomics. 2006;25:263-76 pubmed
    ..We used the isotope-coded affinity tag (ICAT) technique to identify IMCD proteins that change in abundance in response to vasopressin...
  29. Kevans D, Wang L, Sheahan K, Hyland J, O Donoghue D, Mulcahy H, et al. Epithelial-mesenchymal transition (EMT) protein expression in a cohort of stage II colorectal cancer patients with characterized tumor budding and mismatch repair protein status. Int J Surg Pathol. 2011;19:751-60 pubmed publisher
    ..001) compared with MSI cases. Epithelial mesenchymal protein expression plays a key role in tumor budding and prognosis in early-stage colorectal cancer and requires further evaluation. ..
  30. Ashihara K, Saito T, Mizumoto H, Adachi K, Tanaka R, Nishimura M, et al. Loss of gamma-Catenin expression in squamous differentiation in endometrial carcinomas. Int J Gynecol Pathol. 2002;21:246-54 pubmed
    ..Our results suggest that unique molecular events, i.e., stimulation of beta-catenin and suppression of gamma-catenin expression, occur within endometrial carcinomas with squamous differentiation. ..
  31. Reichel O, Mayr D, Durst F, Berghaus A. E-cadherin but not beta-catenin expression is decreased in laryngeal biopsies from patients with laryngopharyngeal reflux. Eur Arch Otorhinolaryngol. 2008;265:937-42 pubmed publisher
    ..E-cadherin immunostaining of laryngeal biopsies could be a further diagnostic tool to confirm the diagnosis in patients with suspected LPR. ..
  32. Wang W, Zhang X, Deng K, Huang S, Mao X, Fu Y, et al. ICAT as a potential enhancer of monocytic differentiation: implications from the comparative proteome analysis of the HL60 cell line stimulated by all-trans retinoic acid and NSC67657. Cell Biochem Funct. 2009;27:329-37 pubmed publisher
    ..After verification by RT-PCR, Western blotting, and immunocytochemistry, only the protein ICAT was found to be elevated by NSC67657 treatment alone...
  33. Chen Q, Song Y, Yu L, Wei J, Chung J, Hewitt S, et al. Global genomic and proteomic analysis identifies biological pathways related to high-risk neuroblastoma. J Proteome Res. 2010;9:373-82 pubmed publisher
    ..on NB tumors of stage 4 MYCN-amplified (4+) and stage 1 MYCN-not-amplified (1-) using isotope-coded affinity tags (ICAT) and Affymetrix U133plus2 microarray, respectively...
  34. Chung Y, Kim H, Park S, Yoon J, Kim M, Nam S, et al. Transcriptome analysis reveals that Müllerian inhibiting substance regulates signaling pathways that contribute to endometrial carcinogenesis. Int J Oncol. 2015;46:2039-46 pubmed publisher
    ..of cell cycle inhibitory genes, apoptotic protease activating factor-1 (APAF-1), β-catenin-interacting protein (ICAT), Rb related protein 130 (p130), and inhibitor of disheveled Dvl and Axin complex (IDAX), were gradually increased ..
  35. Wu G, Liu A, Zhu J, Lei F, Wu S, Zhang X, et al. MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway. Oncotarget. 2015;6:28882-94 pubmed publisher
    ..and suppressing secreted Frizzled-related protein 1 (SFRP1), AXIN2 and inhibitor of β-catenin and TCF-4 (ICAT), which are vital negative regulators of the Wnt/β-catenin pathway...
  36. Sethi S, Chourasia D, Parhar I. Approaches for targeted proteomics and its potential applications in neuroscience. J Biosci. 2015;40:607-27 pubmed
    ..This review will also discuss advanced approaches for targeted proteomics using isotope-coded affinity tag (ICAT) coupled with laser capture microdissection (LCM) followed by liquid chromatography tandem mass spectrometric (LC-..
  37. Selbach M, Mann M. Protein interaction screening by quantitative immunoprecipitation combined with knockdown (QUICK). Nat Methods. 2006;3:981-3 pubmed
    ..We used this screen to identify interaction partners of beta-catenin and Cbl. ..
  38. Fan X, Ma X, Cui L, Dang S, Qu J, Zhang J, et al. CARF activates beta-catenin/TCF signaling in the hepatocellular carcinoma. Oncotarget. 2016;7:80404-80414 pubmed publisher
    ..mechanism study, CARF was found to interact with beta-catenin, impaired the interaction between beta-catenin and ICAT, and activated beta-catenin/TCF signaling...
  39. Haworth T, Haverinen J, Shiels H, Vornanen M. Electrical excitability of the heart in a Chondrostei fish, the Siberian sturgeon (Acipenser baerii). Am J Physiol Regul Integr Comp Physiol. 2014;307:R1157-66 pubmed publisher
    ..b>ICaT/ICaL ratio of the sturgeon atrial myocytes (2.42) is the highest value ever measured for a vertebrate species...
  40. Yang Y, Yang J, Tao H, Jin W. New perspectives on β-catenin control of cell fate and proliferation in colon cancer. Food Chem Toxicol. 2014;74:14-9 pubmed publisher
    ..These results show that β-catenin may serve as a good diagnosis biomarker of early-stage tumor development and a novel potential therapeutic target for colon cancer. ..
  41. Petter E, Lusk N, Hesslow G, Meck W. Interactive roles of the cerebellum and striatum in sub-second and supra-second timing: Support for an initiation, continuation, adjustment, and termination (ICAT) model of temporal processing. Neurosci Biobehav Rev. 2016;71:739-755 pubmed publisher
  42. Park S, Chung Y, Song J, Kim S, Pépin D, MacLaughlin D, et al. Müllerian inhibiting substance inhibits an ovarian cancer cell line via ?-catenin interacting protein deregulation of the Wnt signal pathway. Int J Oncol. 2017;50:1022-1028 pubmed publisher
    ..that MIS/AMH inhibits ovarian cancer by deregulating the Wnt signal pathway via the ?-catenin interacting protein (ICAT)...
  43. Lee J, Marshall J, Steeg P, Horak C. Altered gene and protein expression by Nm23-H1 in metastasis suppression. Mol Cell Biochem. 2009;329:141-8 pubmed publisher
    ..In addition, isotope capture affinity tag (ICAT) proteomic analysis was performed to identify differentially expressed proteins not accounted for by microarray ..
  44. Plachtovics M, Goczan J, Nagy K. The effect of calibration and detector temperature on the reconstructed cone beam computed tomography image quality: a study for the workflow of the iCAT Classic equipment. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:473-80 pubmed publisher
    ..the evaluation of image quality, including spatial accuracy and density response with and without WUP and CP using iCAT Classic equipment...
  45. Marron J, DuBois S, Glade Bender J, Kim A, Crompton B, Meyer S, et al. Patient/parent perspectives on genomic tumor profiling of pediatric solid tumors: The Individualized Cancer Therapy (iCat) experience. Pediatr Blood Cancer. 2016;63:1974-82 pubmed publisher
    ..We surveyed individuals who previously underwent GTP through the iCat (Individualized Cancer Therapy) pilot study of molecular profiling in children with relapsed, refractory, and high-..
  46. Sano M, Driscoll D, DeJesus Monge W, Quattrochi B, Appleman V, Ou J, et al. Activation of WNT/?-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61. Neoplasia. 2016;18:785-794 pubmed publisher
    ..In contrast, these phenotypes were significantly impaired by the introduction of ICAT, an inhibitor of the ?-catenin/TCF4 interaction...
  47. Pereira T, Diniz M, França J, Moreira R, Menezes G, Sousa S, et al. The Wnt/?-catenin pathway is deregulated in cemento-ossifying fibromas. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018;125:172-178 pubmed publisher
    ..Although NGS detected no oncogenic mutation, deregulation of key Wnt/?-catenin signaling pathway genes appears to be relevant to the molecular pathogenesis of COF. ..
  48. von Koch C, Gulati M, Aldape K, Berger M. Familial medulloblastoma: case report of one family and review of the literature. Neurosurgery. 2002;51:227-33; discussion 233 pubmed
    ..We briefly summarize all published cases of familial medulloblastoma and review the literature on the genes involved in medulloblastoma formation. ..
  49. Muraki K, Ohnishi K, Takezawa A, Suzuki H, Hatano N, Muraki Y, et al. Na+ entry through heteromeric TRPC4/C1 channels mediates (-)Englerin A-induced cytotoxicity in synovial sarcoma cells. Sci Rep. 2017;7:16988 pubmed publisher
    ..EA induced cation channel current (Icat) in SW982 cells with biophysical characteristics of heteromeric TRPC4/C1 channels...
  50. Wang H, Tekpetey F, Kidder G. Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells. Mol Hum Reprod. 2009;15:11-7 pubmed publisher
    ..The results suggest that WNT2 could act through its receptor FZD9 to regulate the beta-CATENIN pathway in cumulus cells, recruiting beta-CATENIN into plasma membranes and promoting the formation of adherens junctions involving CDH1. ..
  51. Matsuzaki E, Hiratsuka S, Hamachi T, Takahashi Yanaga F, Hashimoto Y, Higashi K, et al. Sphingosine-1-phosphate promotes the nuclear translocation of ?-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines. Bone. 2013;55:315-24 pubmed publisher
  52. Bertoldo D, Khan M, Dessen P, Held W, Huelsken J, Heinis C. Phage Selection of Peptide Macrocycles against β-Catenin To Interfere with Wnt Signaling. ChemMedChem. 2016;11:834-9 pubmed publisher
    ..The binding site of one group of ligands was mapped to the interaction region of the translational Wnt inhibitor ICAT (inhibitor of β-catenin and Tcf), which is a prime target site on β-catenin for therapeutic intervention, and ..
  53. You S, Zhang F, Meng F, Li H, Liu Q, Liang Y, et al. EBV-encoded LMP1 increases nuclear β-catenin accumulation and its transcriptional activity in nasopharyngeal carcinoma. Tumour Biol. 2011;32:623-30 pubmed publisher
    ..Moreover, LMP1 expression was closely related to abnormal β-catenin expression in NPC tissues by immunohistochemistry. LMP1 may be involved in nasopharyngeal carcinogenesis via β-catenin signaling pathway. ..
  54. Ou C, LaBonte M, Manegold P, So A, Ianculescu I, Gerke D, et al. A coactivator role of CARM1 in the dysregulation of ?-catenin activity in colorectal cancer cell growth and gene expression. Mol Cancer Res. 2011;9:660-70 pubmed publisher
  55. Chen Q, Cai J, Wang Q, Wang Y, Liu M, Yang J, et al. Long Noncoding RNA NEAT1, Regulated by the EGFR Pathway, Contributes to Glioblastoma Progression Through the WNT/β-Catenin Pathway by Scaffolding EZH2. Clin Cancer Res. 2018;24:684-695 pubmed publisher
    ..was critical for glioma cell growth and invasion by increasing β-catenin nuclear transport and downregulating ICAT, GSK3B, and Axin2...
  56. Takeda K, Kinoshita I, Shimizu Y, Ohba Y, Itoh T, Matsuno Y, et al. Clinicopathological significance of expression of p-c-Jun, TCF4 and beta-Catenin in colorectal tumors. BMC Cancer. 2008;8:328 pubmed publisher
    ..These results suggest that nuclear expression of p-c-Jun, TCF4 and beta-Catenin have important roles in human colorectal tumor development and that p-c-Jun may play a pivotal role in the earlier stages of tumor development. ..
  57. Domingues M, Martinez Sanz J, Papon L, Larue L, Mouawad L, Bonaventure J. Structure-based mutational analysis of ICAT residues mediating negative regulation of ?-catenin co-transcriptional activity. PLoS ONE. 2017;12:e0172603 pubmed publisher
    b>ICAT (Inhibitor of ?-CAtenin and TCF) is a small acidic protein that negatively regulates ?-catenin co-transcriptional activity by competing with TCF/LEF factors in their binding to ?-catenin superhelical core...
  58. Armanious H, Gelebart P, Mackey J, Ma Y, Lai R. STAT3 upregulates the protein expression and transcriptional activity of ?-catenin in breast cancer. Int J Clin Exp Pathol. 2010;3:654-64 pubmed
  59. Meckel S, Taschner C, Elsheikh S, Maurer C, Urbach H. [Mechanical thrombectomy for acute ischemic stroke : current evidence and open questions]. Nervenarzt. 2015;86:1226-35 pubmed publisher
    ..The use of MT is more effective than IVT for internal carotid artery terminus (ICAT), M1 segment and tandem occlusions, i.e...
  60. Fan X, Zhou S, Wang B, Hom G, Guo M, Li B, et al. Evidence of Highly Conserved β-Crystallin Disulfidome that Can be Mimicked by In Vitro Oxidation in Age-related Human Cataract and Glutathione Depleted Mouse Lens. Mol Cell Proteomics. 2015;14:3211-23 pubmed publisher
    ..2D-PAGE and proteomics, and then systematically identified in vivo and in vitro all disulfide forming sites using ICAT labeling method coupled with proteomics...
  61. Park C, Hahm E, Park S, Kim H, Yang C. The inhibitory mechanism of curcumin and its derivative against beta-catenin/Tcf signaling. FEBS Lett. 2005;579:2965-71 pubmed
  62. Zhang K, Zhu S, Liu Y, Dong X, Shi Z, Zhang A, et al. ICAT inhibits glioblastoma cell proliferation by suppressing Wnt/β-catenin activity. Cancer Lett. 2015;357:404-11 pubmed publisher
    Inhibitor of β-catenin and T-cell factor (ICAT) is a key component of Wnt/β-catenin signaling...
  63. Sirenko S, Maltsev V, Yaniv Y, Bychkov R, Yaeger D, Vinogradova T, et al. Electrochemical Na+ and Ca2+ gradients drive coupled-clock regulation of automaticity of isolated rabbit sinoatrial nodal pacemaker cells. Am J Physiol Heart Circ Physiol. 2016;311:H251-67 pubmed publisher
    ..modeling predicted that, as the ENa and ECa monotonically reduced over time in response to DG, ion currents (ICaL, ICaT, If, IKr, and IbNa) monotonically decreased...
  64. Penman G, Leung L, Nathke I. The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions. J Cell Sci. 2005;118:4741-50 pubmed
  65. Kim S, Lee O, Kwon J, Kim J, Sul H, Song K, et al. Altered Expression of Yes-associated Protein and β-Catenin in Non-neoplastic and Neoplastic Gastric Surface Epithelia. Anticancer Res. 2015;35:3925-31 pubmed
  66. Zirn B, Samans B, Wittmann S, Pietsch T, Leuschner I, Graf N, et al. Target genes of the WNT/beta-catenin pathway in Wilms tumors. Genes Chromosomes Cancer. 2006;45:565-74 pubmed
    ..This article contains Supplementary Material available at http://www.interscience.wiley.com/jpages/1045-2257/suppmat. ..
  67. Kang D, Lee B, Suh Y, Choi Y, Jang S, Kim Y, et al. Phospholipase D1 Inhibition Linked to Upregulation of ICAT Blocks Colorectal Cancer Growth Hyperactivated by Wnt/?-Catenin and PI3K/Akt Signaling. Clin Cancer Res. 2017;23:7340-7350 pubmed publisher
    ..molecular crosstalk between the Wnt/?-catenin and PI3K/Akt pathways via inhibitor of ?-catenin and T-cell factor (ICAT), a negative regulator of Wnt/?-catenin signaling...
  68. Alves Pereira K, do Amaral B, dos Santos B, Galvão H, Freitas R, de Souza L. Immunohistochemical expression of E-cadherin and beta-catenin in ameloblastomas and tooth germs. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:425-31 pubmed publisher
    ..The expression of these molecules seems mainly to be related to the process of cell differentiation. ..
  69. Ruffner H, Sprunger J, Charlat O, Leighton Davies J, Grosshans B, Salathe A, et al. R-Spondin potentiates Wnt/?-catenin signaling through orphan receptors LGR4 and LGR5. PLoS ONE. 2012;7:e40976 pubmed publisher
    ..Identification of LGR4 and its relative LGR5, an adult stem cell marker, as the receptors of RSPO will facilitate the further characterization of these receptor/ligand pairs in regenerative medicine applications. ..
  70. Ono M, Yin P, Navarro A, Moravek M, Coon V J, Druschitz S, et al. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertil Steril. 2014;101:1441-9 pubmed publisher
    To assess the effect of three WNT/β-catenin pathway inhibitors-inhibitor of β-catenin and TCF4 (ICAT), niclosamide, and XAV939-on the proliferation of primary cultures of human uterine leiomyoma cells...
  71. Evans C, Glen A, Eaton C, Larré S, Catto J, Hamdy F, et al. Prostate cancer proteomics: The urgent need for clinically validated biomarkers. Proteomics Clin Appl. 2009;3:197-212 pubmed publisher
    ..urine, serum, tissues, and cell lines have been studied using proteomic approaches such as 2-DE, SELDI-TOF, SILAC, ICAT, iTRAQ, and MALDI-IMS...
  72. Fu X, Zhu X, Qin F, Zhang Y, Lin J, Ding Y, et al. Linc00210 drives Wnt/β-catenin signaling activation and liver tumor progression through CTNNBIP1-dependent manner. Mol Cancer. 2018;17:73 pubmed publisher
    ..Linc00210 interacts with CTNNBIP1 and blocks the combination between CTNNBIP1 and β-catenin, driving the activation of Wnt/β-catenin signaling. Linc00210-CTNNBIP1-Wnt/β-catenin axis can be targeted for liver TIC elimination. ..
  73. Tago K, Nakamura T, Nishita M, Hyodo J, Nagai S, Murata Y, et al. Inhibition of Wnt signaling by ICAT, a novel beta-catenin-interacting protein. Genes Dev. 2000;14:1741-9 pubmed
    ..Here, we identify a novel beta-catenin-interacting protein, ICAT, that was found to inhibit the interaction of beta-catenin with TCF-4 and represses beta-catenin-TCF-4-mediated ..
  74. Yochum G, Cleland R, Goodman R. A genome-wide screen for beta-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression. Mol Cell Biol. 2008;28:7368-79 pubmed publisher
    ..Our findings indicate that a downstream enhancer element provides the principal regulation of c-Myc expression. ..
  75. Konsavage W, Yochum G. Intersection of Hippo/YAP and Wnt/?-catenin signaling pathways. Acta Biochim Biophys Sin (Shanghai). 2013;45:71-9 pubmed publisher
    ..In this review, we will discuss the points of intersection between the Wnt/?-catenin and Hippo/YAP pathways and how these interactions contribute to homeostasis, organ repair, and tumorigenesis. ..
  76. Pereira Maciel P, Tavares de Sousa E, Oliveira Sales M. The mandibular incisive canal and its anatomical relationships: A cone beam computed tomography study. Med Oral Patol Oral Cir Bucal. 2015;20:e723-8 pubmed
    ..views (axial, panoramic and cross-sectional) and three-dimensional representations were performed using iCAT CBCT software...
  77. Daniels D, Weis W. ICAT inhibits beta-catenin binding to Tcf/Lef-family transcription factors and the general coactivator p300 using independent structural modules. Mol Cell. 2002;10:573-84 pubmed
    ..The crystal structure of ICAT, an inhibitor of beta-catenin-mediated transcription, bound to the armadillo repeat domain of beta-catenin, has ..
  78. Mukherjee N, Dasgupta H, Bhattacharya R, Pal D, Roy R, Islam S, et al. Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance. Biochim Biophys Acta. 2016;1862:1472-84 pubmed publisher
    ..Thus, our data suggests that inactivation of MCC/CTNNBIP1 could be an important event in activation of β-catenin mediated transcription of target genes in BC. ..
  79. Flozak A, Lam A, Gottardi C. A Simple Method to Assess Abundance of the β-Catenin Signaling Pool in Cells. Methods Mol Biol. 2016;1481:49-60 pubmed publisher
    ..allows for simple assessment of the cadherin-free fraction of β-catenin in cells, using a GST-tagged form of ICAT (Inhibitor of β-Catenin and Tcf) as an affinity matrix...
  80. Zhang H, Yu C, Dai J, Keller J, Hua A, Sottnik J, et al. Parathyroid hormone-related protein inhibits DKK1 expression through c-Jun-mediated inhibition of ?-catenin activation of the DKK1 promoter in prostate cancer. Oncogene. 2014;33:2464-77 pubmed publisher
    ..Together, these results demonstrate a novel signaling linkage between PTHrP and Wnt signaling pathways that results in downregulation of a Wnt inhibitor allowing for Wnt activity that could contribute the osteoblastic nature of PCa. ..
  81. Scherbakov A, Stefanova L, Sorokin D, Semina S, Berstein L, Krasil nikov M. Snail/beta-catenin signaling protects breast cancer cells from hypoxia attack. Exp Cell Res. 2013;319:3150-9 pubmed publisher
    ..Moreover, we suggest that the level of these proteins as well the level of AMPK phosphorylation may be considered as predictors of the tumor sensitivity to anti-angiogenic drugs. ..
  82. Bazas V, Lukyanova N, Demash D, Galakhin K, Myasoedov D. Relation between cell-to-cell adhesion and angiogenesis and clinico-morphological prognostic factors in patients with gastric cancer. Exp Oncol. 2008;30:235-9 pubmed
    ..At the base of combined clinical, histological and immunohistochemical analysis of gastric tumors it has been shown that E-cadherin, alpha-catenin and VEGF could be used as informative markers of the disease course. ..
  83. Kim Y, Kim J, Bae Y, Suh K, Jung J. ICAT participates in proliferation and osteogenic differentiation of human adipose tissue-derived mesenchymal stem cell. Life Sci. 2008;83:851-8 pubmed publisher
    ..Therefore, in the present study, we investigated how ICAT (inhibitor of beta-catenin and TCF-4), a negative regulator of the Wnt signaling pathway, influenced ..
  84. Iwai S, Yonekawa A, Harada C, Hamada M, Katagiri W, Nakazawa M, et al. Involvement of the Wnt-?-catenin pathway in invasion and migration of oral squamous carcinoma cells. Int J Oncol. 2010;37:1095-103 pubmed
    ..This would enhance the invasion and migration of oral SCC cells. ..
  85. Zhang Y, Li T, Guo P, Kang J, Wei Q, Jia X, et al. MiR-424-5p reversed epithelial-mesenchymal transition of anchorage-independent HCC cells by directly targeting ICAT and suppressed HCC progression. Sci Rep. 2014;4:6248 pubmed publisher
    ..Target analysis showed that a potent β-catenin inhibitor, ICAT/CTNNBIP1 was a direct target of miR-424-5p...
  86. Umbreit C, Erben P, Faber A, Hofheinz R, Aderhold C, Weiss C, et al. MMP9, Cyclin D1 and β-Catenin Are Useful Markers of p16-positive Squamous Cell Carcinoma in Therapeutic EGFR Inhibition In Vitro. Anticancer Res. 2015;35:3801-10 pubmed
    ..The presented cell culture model is, therefore, well-suited for further study of epigenetic regulation of molecular targeted-therapy by EGFR inhibition and prevention of mesenchymal transition in p16-positive SCC cells. ..
  87. Seo E, Jho E. Axin-independent phosphorylation of APC controls beta-catenin signaling via cytoplasmic retention of beta-catenin. Biochem Biophys Res Commun. 2007;357:81-6 pubmed
    ..The retained beta-catenin in cytoplasm by APC may be down-regulated by Axin 2, which is induced by beta-catenin/Tcf signaling. ..
  88. Guo M, Breslin J, Wu M, Gottardi C, Yuan S. VE-cadherin and beta-catenin binding dynamics during histamine-induced endothelial hyperpermeability. Am J Physiol Cell Physiol. 2008;294:C977-84 pubmed publisher
    ..assessed the ability of a beta-catenin binding polypeptide known as inhibitor of beta-catenin and T cell factor (ICAT) to compete beta-catenin binding to VE-cadherin in vitro...
  89. Lill C, Schneider S, Ghanim B, Brunner M, Heiduschka G, Loewe R, et al. Expression of ?-catenin and cyclin D1 in Merkel cell carcinomas of the head and neck. Wien Klin Wochenschr. 2013;125:501-7 pubmed publisher
    ..We could describe the expression pattern of cyclin D1 for the first time. ..
  90. Domingues M, Rambow F, Job B, Papon L, Liu W, Larue L, et al. ?-catenin inhibitor ICAT modulates the invasive motility of melanoma cells. Cancer Res. 2014;74:1983-95 pubmed publisher
    Inhibitor of ?-catenin and TCF (ICAT) inhibits ?-catenin transcriptional activity by competing with T-cell factor/lymphoid enhancer factor...
  91. Erdem H, Gundogdu B, Ankarali H, Yasar M, Sener E, Oktay M, et al. Correlation of astrocyte elevated gene-1, basic-fibroblast growth factor, beta-catenin, Ki-67, tumor necrosis factor-alfa with prognostic parameters in ductal carcinomas and ductal intraepithelial neoplasms. Niger J Clin Pract. 2015;18:638-43 pubmed publisher
    ..We found a relationship between these factors. ..
  92. Choi H, Huber A, Weis W. Thermodynamics of beta-catenin-ligand interactions: the roles of the N- and C-terminal tails in modulating binding affinity. J Biol Chem. 2006;281:1027-38 pubmed
    ..The thermodynamics of beta-catenin binding to E-cadherin, Lef-1, APC, axin, and the transcriptional inhibitor ICAT have been determined by isothermal titration calorimetry...