I mfa domain containing protein

Summary

Gene Symbol: I mfa domain containing protein
Description: MyoD family inhibitor domain containing
Alias: HIC, I-mfa domain-containing protein, myoD family inhibitor domain-containing protein
Species: human

Top Publications

  1. pmc Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import
    Lili Gu
    UCD Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin UCD, Belfield, Dublin 4, Ireland
    Retrovirology 8:17. 2011
  2. ncbi Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression
    S Thebault
    Institut de Biologie, Laboratoire Infections Retrovirales et Signalisation Cellulaire, CRBM CNRS UPR 1086, 4 Boulevard Henri IV, 34060 Montpellier, France
    J Biol Chem 275:4848-57. 2000
  3. ncbi HIC gene, a candidate suppressor gene within a minimal region of loss at 7q31.1 in myeloid neoplasms
    Daniela Cigognini
    Department of Medicine, Surgery and Dentistry, University of Milan, Via di Rudini 8, 20142 Milano, Italy
    Leuk Res 31:477-82. 2007
  4. doi Expression profile and differential regulation of the Human I-mfa domain-Containing protein (HIC) gene in immune cells
    Lili Gu
    School of Medicine and Medical Science, Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland
    Immunol Lett 123:179-84. 2009
  5. pmc The complex regulation of HIC (Human I-mfa domain containing protein) expression
    Ella Reiss-Sklan
    Department of Biological Chemistry, Institute of Life Science, The Hebrew University, Jerusalem, Israel
    PLoS ONE 4:e6152. 2009
  6. doi Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription
    Shuichi Kusano
    Division of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 396:608-13. 2010
  7. pmc Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription
    Qi Wang
    University of Medicine and Dentistry of New Jersey, Department of Biochemistry and Molecular Biology, New Jersey Medical School, Newark, NJ 07103 2714, USA
    J Mol Biol 367:630-46. 2007
  8. pmc The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription
    Tara M Young
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07013 2714, USA
    Mol Cell Biol 23:6373-84. 2003
  9. pmc I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways
    Shuichi Kusano
    Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, 27599 7295, USA
    Mol Cell Biol 22:6393-405. 2002
  10. doi The 3'UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells
    Jaron Liu
    Expression Engineering Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, 20 Biopolis Way, 06 01 Centros, Singapore 138668, Singapore
    J Biotechnol 139:152-5. 2009

Research Grants

  1. METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORS
    Stephen Baylin; Fiscal Year: 2007
  2. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2007
  3. Massive Iron Deposit Assessment (MIDAS)
    CLAUDIA M contact HILLENBRAND; Fiscal Year: 2010
  4. Room Temp Susceptometry For Hepatic Iron Measurement
    Kris Kowdley; Fiscal Year: 2006
  5. Matrix & Lysolipids Regulate Endothelial Cell Migration
    TRACEE PANETTI; Fiscal Year: 2006
  6. INTRACELLULAR MECHANISMS OF GLUCOCORTICOID ACTION
    Donald Defranco; Fiscal Year: 2005
  7. STRUCTURE AND FUNCTION OF PAXILLIN
    Christopher Turner; Fiscal Year: 2009
  8. STRUCTURE AND FUNCTION OF PAXILLIN
    Christopher E Turner; Fiscal Year: 2010
  9. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven Belinsky; Fiscal Year: 2002
  10. Regulation of Podocyte Structure by the Binding Protein
    William Smoyer; Fiscal Year: 2006

Detail Information

Publications140 found, 100 shown here

  1. pmc Intermolecular masking of the HIV-1 Rev NLS by the cellular protein HIC: novel insights into the regulation of Rev nuclear import
    Lili Gu
    UCD Centre for Research in Infectious Diseases, School of Medicine and Medical Science, University College Dublin UCD, Belfield, Dublin 4, Ireland
    Retrovirology 8:17. 2011
    ..However, it remains unclear which nuclear import pathway(s) predominate in vivo, and the cellular environment that modulates Rev nucleocytoplasmic shuttling remains to be characterised...
  2. ncbi Molecular cloning of a novel human I-mfa domain-containing protein that differently regulates human T-cell leukemia virus type I and HIV-1 expression
    S Thebault
    Institut de Biologie, Laboratoire Infections Retrovirales et Signalisation Cellulaire, CRBM CNRS UPR 1086, 4 Boulevard Henri IV, 34060 Montpellier, France
    J Biol Chem 275:4848-57. 2000
    ..The synthesis of this new factor, called HIC for Human I-mfa domain-Containing protein, is controlled at the translational level by two different codons, an ATG ..
  3. ncbi HIC gene, a candidate suppressor gene within a minimal region of loss at 7q31.1 in myeloid neoplasms
    Daniela Cigognini
    Department of Medicine, Surgery and Dentistry, University of Milan, Via di Rudini 8, 20142 Milano, Italy
    Leuk Res 31:477-82. 2007
    ..The closest gene to our most deleted microsatellite, D7S2554, is the human I-mfa domain containing (HIC) gene, alias MyoD family inhibitor domain containing (MDFIC)...
  4. doi Expression profile and differential regulation of the Human I-mfa domain-Containing protein (HIC) gene in immune cells
    Lili Gu
    School of Medicine and Medical Science, Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland
    Immunol Lett 123:179-84. 2009
    The Human I-mfa domain-Containing protein, HIC, is a 246 amino acid protein that functions as a transcriptional regulator...
  5. pmc The complex regulation of HIC (Human I-mfa domain containing protein) expression
    Ella Reiss-Sklan
    Department of Biological Chemistry, Institute of Life Science, The Hebrew University, Jerusalem, Israel
    PLoS ONE 4:e6152. 2009
    Human I-mfa domain containing protein (HIC) differentially regulates transcription from viral promoters. HIC affects the Wnt pathway, the JNK/SAPK pathway and the activity of positive transcription elongation factor-b (P-TEFb)...
  6. doi Human I-mfa domain proteins specifically interact with KSHV LANA and affect its regulation of Wnt signaling-dependent transcription
    Shuichi Kusano
    Division of Persistent and Oncogenic Viruses, Center for Chronic Viral Diseases, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
    Biochem Biophys Res Commun 396:608-13. 2010
    ..We show here that the I-mfa domain proteins, HIC (human I-mfa domain-containing protein) and I-mfa (inhibitor of MyoD family a), interacted in vivo with LANA ..
  7. pmc Developmental regulators containing the I-mfa domain interact with T cyclins and Tat and modulate transcription
    Qi Wang
    University of Medicine and Dentistry of New Jersey, Department of Biochemistry and Molecular Biology, New Jersey Medical School, Newark, NJ 07103 2714, USA
    J Mol Biol 367:630-46. 2007
    ..The related I-mfa (inhibitor of MyoD family a) and HIC (human I-mfa-domain-containing) proteins function in myogenic differentiation and embryonic development by ..
  8. pmc The human I-mfa domain-containing protein, HIC, interacts with cyclin T1 and modulates P-TEFb-dependent transcription
    Tara M Young
    Department of Biochemistry and Molecular Biology, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07013 2714, USA
    Mol Cell Biol 23:6373-84. 2003
    ..Among the proteins isolated was the human I-mfa domain-containing protein (HIC)...
  9. pmc I-mfa domain proteins interact with Axin and affect its regulation of the Wnt and c-Jun N-terminal kinase signaling pathways
    Shuichi Kusano
    Lineberger Comprehensive Cancer Center, School of Medicine, University of North Carolina, Chapel Hill, 27599 7295, USA
    Mol Cell Biol 22:6393-405. 2002
    ..of myogenic basic helix-loop-helix transcription factors, and a related human I-mfa domain-containing protein (HIC) also has been identified as a protein that regulates Tat- and Tax-mediated expression of viral promoters...
  10. doi The 3'UTR of HIC mRNA improves the production of recombinant proteins in Chinese hamster ovary cells
    Jaron Liu
    Expression Engineering Group, Bioprocessing Technology Institute, Agency for Science, Technology and Research A STAR, 20 Biopolis Way, 06 01 Centros, Singapore 138668, Singapore
    J Biotechnol 139:152-5. 2009
    ..It has been reported that the human I-mfa (inhibitor of MyoD family a) domain-containing protein (HIC) interacts with P-TEFb and that expression of HIC cDNA stimulates P-TEFb-dependent transcription...
  11. pmc Direct interaction of the human I-mfa domain-containing protein, HIC, with HIV-1 Tat results in cytoplasmic sequestration and control of Tat activity
    Virginie W Gautier
    Department of Medical Microbiology, Centre for Research in Infectious Diseases, Conway Institute of Molecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Proc Natl Acad Sci U S A 102:16362-7. 2005
    ..we report and characterize the interaction of the human inhibitor of MyoD family domain-containing protein (I-mfa), HIC, with Tat at a biochemical and a functional level...
  12. ncbi Leaking urine in Australian women: prevalence and associated conditions
    P Chiarelli
    Hunter Centre for Health Advancement
    Women Health 29:1-13. 1999
    ..mid-age women, 45-50 (N = 13,738) and older women, 70-75 (N = 12,417), were recruited randomly from the national HIC/Medicare database. Leaking urine was reported by approximately one in eight young women [estimated prevalence 12...
  13. ncbi Siderophore production by enterotoxigenic Salmonella
    S F Jiwa
    Department of Microbiology and Parasitology, Faculty of Veterinary Medicine, Sokoine University of Agriculture, Morogoro, Tanzania
    Zentralbl Bakteriol Mikrobiol Hyg A 266:338-46. 1987
    Eleven Salmonella strains of diverse origin studied previously for enterotoxigenicity, cell surface hydrophobicity (HIC) and haemagglutination (HA) were studied for the production of a siderophore precursor 2,3-dihydroxybenzoic acid (DHB)..
  14. ncbi Enhanced cancer growth in mice administered daily human-equivalent doses of some H1-antihistamines: predictive in vitro correlates
    L J Brandes
    Department of Medicine, Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Canada
    J Natl Cancer Inst 86:770-5. 1994
    ..It is thought that potency to bind to intracellular histamine receptors (HIC), some of which are on cytochromes P450, may correlate with tumor growth-promoting activity.
  15. ncbi Acacia senegal gum: continuum of molecular species differing by their protein to sugar ratio, molecular weight, and charges
    Denis Renard
    Unité de recherches Biopolymères, Interactions, Assemblages, INRA, rue de la Geraudiere, BP 71627 44316 Nantes Cedex 3, France
    Biomacromolecules 7:2637-49. 2006
    ..Three main molecular fractions were isolated after hydrophobic interaction chromatography (HIC) and biochemical analyses confirmed the presence of an arabinogalactan-peptide (FI), an arabinogalactan-protein (..
  16. ncbi [Investigation of hydrophobic characteristics of biofilm producer and non-producer Staphylococcus aureus clinical isolates]
    Selma Ay
    Inonu Universitesi Tip Fakultesi, Tibbi Mikrobiyoloji Anabilim Dali, Malatya
    Mikrobiyol Bul 44:221-30. 2010
    ..and phenyl-sepharose; Amersham Bioscience, Sweden) were studied by using hydrophobic interaction chromatography (HIC) method. After butyl- and octyl-sepharose chromatography, it was determined that slime negative S...
  17. ncbi New approach for separating Bacillus subtilis metalloprotease and alpha-amylase by affinity chromatography and for purifying neutral protease by hydrophobic chromatography
    I Lauer
    Centre de Recherche TEPRAL, Branche Boissons du Groupe Danone, Strasbourg, France
    J Chromatogr B Biomed Sci Appl 737:277-84. 2000
    ..Purification was achieved by means of affinity chromatography on Cibacron Blue and HIC as a polishing step...
  18. ncbi Ethanol tolerance and withdrawal responses in GABA(A) receptor alpha 6 subunit null allele mice and in inbred C57BL/6J and strain 129/SvJ mice
    G E Homanics
    Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania 15261, USA
    Alcohol Clin Exp Res 22:259-65. 1998
    ..At the end of the last treatment cycle, mice were scored for handling induced convulsions (HIC)...
  19. ncbi Study of the disulfide reduction of denatured proteins by liquid chromatography coupled with on-line cold-vapor-generation atomic-fluorescence spectrometry (LC-CVGAFS)
    Emilia Bramanti
    Laboratory of Instrumental Analytical Chemistry, Italian National Research Council Istituto per i Processi Chimico Fisici, Via G Moruzzi 1, 56124 Pisa, Italy
    Anal Bioanal Chem 380:310-8. 2004
    ..chromatography coupled on-line with chemical-vapor-generation atomic-fluorescence spectrometry (HIC-CVGAFS), optimized recently for the analysis of thiol-containing proteins under denaturing conditions, has been ..
  20. ncbi Comparison of the protein adsorption selectivity of salt-promoted agarose-based adsorbents. Hydrophobic, thiophilic and electron donor-acceptor adsorbents
    P P Berna
    Biochemical Separation Centre, University of Uppsala, BMC, Sweden
    J Chromatogr A 800:151-9. 1998
    ..The conclusion of this work is two-fold: (1) hydrophobic interaction chromatography (HIC) and electron donor-acceptor chromatography (EDAC) have opposed protein selectivities and are both salt-promoted...
  21. ncbi Ultrastructural sequences during liver iron overload in genetic hemochromatosis
    T C Iancu
    B Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa
    J Hepatol 27:628-38. 1997
    ..The objective of the present study was to describe the ultrastructural changes in liver biopsies of patients in various stages of this condition and to correlate these with clinical, histopathological and biochemical data...
  22. ncbi Multidimensional analysis of denatured milk proteins by hydrophobic interaction chromatography coupled to a dynamic surface tension detector
    Emilia Bramanti
    Laboratory of Instrumental Analytical Chemistry, Istituto per i Processi Chimico Fisici, National Research Council of Italy CNR, Via G Moruzzi 1, 56124 Pisa, Italy
    J Chromatogr A 1023:79-91. 2004
    ..A hydrophobic interaction chromatography (HIC) column (a TSK-Gel Phenyl-5PW column, TosoBiosep), in the presence of 3...
  23. ncbi [Morbidity due to intracerebral hemorrhage]
    F J López-González
    Servicio de Neurologia, Complexo Hospitalario Universitario de Santiago Hospital Xeral de Galicia, Santiago de Compostela, Espana
    Rev Neurol 27:755-8. 1998
    Intracerebral hemorrhage (HIC) represents 10-30% of all stroke. Epidemiological studies have shown factors associated with its high mortality, but those which might lead to lower morbidity are little known.
  24. ncbi Iron overload in patients with chronic hepatitis C virus infection: clinical and histological study
    Ivonete S S Silva
    Department of Gastroenterology, Federal University of Sao Paulo, Rua Botucatu 740, 2nd Floor, CEP 04023 900 São Paulo SP, Brazil
    J Gastroenterol Hepatol 20:243-8. 2005
    ..of the present paper was to determine the prevalence of iron overload and to study the relationship between hepatic iron concentration (HIC) and clinical, biochemical and histological characteristics in chronic HCV-infected carriers.
  25. ncbi Hic-5 promotes endothelial cell migration to lysophosphatidic acid
    C Avraamides
    Department of Microbiology and Immunology, and Sol Sherry Thrombosis Research Center, Temple University School of Medicine, 3400 N Broad Street, Philadelphia, PA 19140, USA
    Am J Physiol Heart Circ Physiol 293:H193-203. 2007
    ..Hydrogen peroxide-inducible clone 5 (Hic-5), a paxillin family member, is enriched in the focal adhesions in bovine pulmonary artery endothelial (BPAE) ..
  26. ncbi Interaction of fibrinogen with n-alkylagaroses and its purification by critical hydrophobicity hydrophobic interaction chromatograpy
    Herbert P Jennissen
    Institut fur Physiologische Chemie, Universitat Duisburg Essen, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen 1, Germany
    J Chromatogr A 1109:197-213. 2006
    A rational application of hydrophobic interaction chromatography (HIC) to the purification of proteins has remained an enigma in spite of over 30 years of research...
  27. doi Hepatic iron overload in children with sickle cell anemia on chronic transfusion therapy
    Kathy Brown
    Department of Pediatric, Division of Pediatric Gastroenterology, Blair E Batson Hospital for Children, University of Mississippi Medical Center, Jackson, MS 39216, USA
    J Pediatr Hematol Oncol 31:309-12. 2009
    ..No firm consensus has been reached with regard to correlation between hepatic iron content (HIC) and variables including age, number of transfusions, and serum iron makers...
  28. pmc Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix
    L Yang
    Department of Pathology and Department of Biochemistry and Molecular Biology, University of Southern California, Los Angeles, California 90089, USA
    Mol Biol Cell 11:2007-18. 2000
    b>Hic-5 (hydrogen peroxide-inducible clone-5) is a focal adhesion protein that is involved in cellular senescence...
  29. pmc Changes in solvent exposure reveal the kinetics and equilibria of adsorbed protein unfolding in hydrophobic interaction chromatography
    R W Deitcher
    Department of Chemical Engineering, University of Virginia, Charlottesville, VA 22904 4741, USA
    J Chromatogr A 1217:5571-83. 2010
    ..Here, we propose a physically based model of simultaneous protein adsorption, unfolding and hydrogen exchange in HIC. An accompanying experimental protocol, utilizing mass spectrometry to quantify deuterium labeling, enables the ..
  30. doi Anticancer drugs are synergistic with freezing in induction of apoptosis in HCC cells
    FangJun Yuan
    Institute of Liver Surgery, DongFeng Hospital, Yunyang Medical College, 10 Daling Road, Shiyan, Hubei 442008, China
    Cryobiology 57:60-5. 2008
    ..cells (Bel-7402/R), as well as two control cell lines, the HCC cell line SMMC-7721 and a colorectal tumor cell line HIC-251...
  31. doi Monoliths from poly(ethylene glycol) diacrylate and dimethacrylate for capillary hydrophobic interaction chromatography of proteins
    Yuanyuan Li
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA
    J Chromatogr A 1217:4934-45. 2010
    ..chromatographic performance with respect to peak capacity and resolution in hydrophobic interaction chromatography (HIC)...
  32. ncbi Erythrocyte membrane ion transport in offspring of hypertensive parents: effect of acute hyperinsulinemia and relation to insulin action
    Gabriela Suchankova
    Institute for Clinical and Experimental Medicine, and Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
    Ann N Y Acad Sci 967:352-62. 2002
    ..passive membrane permeability) were measured before and after a hyperinsulinemic (75 microU/mL) euglycemic clamp (HIC) and compared to those found under isoinsulinemic isovolumic conditions in OHP and C...
  33. doi Interaction of the porcine reproductive and respiratory syndrome virus nucleocapsid protein with the inhibitor of MyoD family-a domain-containing protein
    Cheng Song
    Department of Pathobiology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Biol Chem 390:215-23. 2009
    ..We identified by yeast two-hybrid screening the inhibitor of MyoD family-a (I-mfa) domain-containing protein (HIC) as a cellular partner for PRRS virus (PRRSV) N protein...
  34. ncbi Concussion in professional football: comparison with boxing head impacts--part 10
    David C Viano
    Mild Traumatic Brain Injury Committee, National Football League, New York, New York, USA
    Neurosurgery 57:1154-72; discussion 1154-72. 2005
    ..Olympic boxers threw four different punches at an instrumented Hybrid III dummy and responses were compared with laboratory-reconstructed NFL concussions...
  35. ncbi The effects of arginine on protein binding and elution in hydrophobic interaction and ion-exchange chromatography
    Tsutomu Arakawa
    Alliance Protein Laboratories, Thousand Oaks, CA 91360, USA
    Protein Expr Purif 54:110-6. 2007
    ..we have examined the effects of arginine on binding and elution of the proteins during hydrophobic interaction (HIC) and ion- exchange chromatographies (IEC) using recombinant monoclonal antibodies (mAbs) and human interleukin-6...
  36. pmc Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B
    S Deltour
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8526, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue Calmette, 59017 Lille Cedex, France
    Proc Natl Acad Sci U S A 96:14831-6. 1999
    Hypermethylated in cancer (HIC-1), a new candidate tumor suppressor gene located in 17p13...
  37. doi Global/local head models to analyse cerebral blood vessel rupture leading to ASDH and SAH
    Mohamad Zoghi-Moghadam
    Department of Mechanical Engineering, The City College of the City University of New York, New York, NY 10031, USA
    Comput Methods Biomech Biomed Engin 12:1-12. 2009
    ..The global models were subjected to two sets of impact loads (head injury criterion, HIC = 740 and 1044). The relative displacements between the brain and skull were determined from GSM...
  38. ncbi Complex formation between PSA isoenzymes and protease inhibitors
    J Leinonen
    Department of Clinical Chemistry, Helsinki University Central Hospital, Finland
    J Urol 155:1099-103. 1996
    ..We have studied complex formation between the isoenzymes of prostate specific antigen (PSA) and protease inhibitors in vitro...
  39. ncbi Organotin contamination in the Atlantic Ocean off the Iberian Peninsula in relation to shipping
    J L Gomez-Ariza
    Department of Chemistry and Material Science, Faculty of Experimental Sciences, University of Huelva, Campus de El Carmen, 21007 Huelva, Spain
    Chemosphere 64:1100-8. 2006
    ..The study was part of a European project (acronym HIC-TBT) co-financed by the EU-LIFE programme, intending to investigate and communicate the impact of organotins from ..
  40. ncbi Nootropic activity of tuber extract of Pueraria tuberosa (Roxb)
    N Venkata Rao
    Department of Pharmacology, V L College of Pharmacy, Raichur 584 103, India
    Indian J Exp Biol 46:591-8. 2008
    ..CIH), lithium-induced (5-HT mediated) head twitches (LIH) and haloperidol-induced (DA- mediated) catalepsy (HIC) models. Piracetam was used as the standard drug...
  41. ncbi [Hospital stay after cerebral hemorrhage]
    J M Lainez
    Servicio de Neurologia, Hospital General Universitario de Valencia, Universidad de Valencia, Espana
    Rev Neurol 25:1121-5. 1997
    ..DEVELOPMENT AND CONCLUSIONS: We therefore review the aetiology, physiopathological course and complications of HIC in order to better understand the circumstances which affect the average hospital stay and identify the factors ..
  42. doi Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla
    Shigeki Inui
    Department of Regenerative Dermatology, Osaka University School of Medicine, 2 2, G2, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Dermatol Sci 61:1-6. 2011
    ..Additionally, AR coactivator Hic-5/ARA55 is highly expressed in dermal papilla cells of hair follicles from androgen-sensitive sites such as AGA and ..
  43. pmc The focal adhesion protein Hic-5 is highly expressed in the rat myometrium during late pregnancy and labour and co-localizes with FAK
    Jenn M Croke
    Division of Basic Medical Sciences, Health Sciences Centre, Faculty of Medicine, Memorial University of Newfoundland, St John s, NL, Canada
    Reprod Biol Endocrinol 5:22. 2007
    ..The focal adhesion protein hydrogen peroxide-inducible clone-5 (Hic-5) has recently been found in mononuclear smooth muscle but was not examined in the myometrium during pregnancy...
  44. ncbi Impact of Triton X-100 on alpha 2-antiplasmin (SERPINF2) activity in solvent/detergent-treated plasma
    Thierry Burnouf
    Research Department, Human Plasma Product Services, 18 rue Saint Jacques, 59800 Lille, France
    Biologicals 35:349-53. 2007
    ..5% (v/v) soybean oil, centrifuged at 3800 x g for 30 min, and subjected to hydrophobic interaction chromatography (HIC) to remove the SD agents...
  45. ncbi Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry
    Kris V Kowdley
    University of Washington, Seattle, 98195, USA
    Gastroenterology 129:494-503. 2005
    ..We examined the effect of HFE mutations on posttransplantation survival in patients with hepatic iron overload...
  46. ncbi [Effect of iron overload on experimental immunological liver injury in rats and the role of angiotensin]
    Jiaju Zhuang
    Physiological department of Bethune Military Medical College, Shijiazhuang 050081, China
    Wei Sheng Yan Jiu 39:101-4. 2010
    ..To investigate the effect of iron overload on experimental immunological liver injury in rats and the roles of losartan (LOS), which is the selective antagonist of angiotensin II receptor subtype AT1...
  47. ncbi [A 3-year study of ultrasound examination of the central nervous system in high risk neonates at the hospital in Senta]
    G Vekonj-Fajka
    Sluzba za zdravstvenu zastitu dece, Zdravstveni centar Dr Gere Istvan, Senta
    Med Pregl 52:259-61. 1999
    ....
  48. ncbi Comparative study of intracytoplasmic sperm injection and in vitro fertilization with high insemination concentration in sibling oocytes in the treatment of unexplained infertility
    Charoenchai Chiamchanya
    Department of Obstetric and Gynecology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
    J Med Assoc Thai 91:1155-60. 2008
    ..couples may have fertilization failure; the in vitro fertilization (IVF) with high insemination concentration (HIC) and intracytoplasmic sperm injection (ICSI) were reported to give better fertilization rate when compared to ..
  49. ncbi Hydrophobic interaction chromatography of proteins. I. The effects of protein and adsorbent properties on retention and recovery
    Brian C S To
    Merck Research Laboratories, Sumneytown Pike, West Point, PA 19486, USA
    J Chromatogr A 1141:191-205. 2007
    ..and adsorbent properties to retention and recovery were examined for hydrophobic interaction chromatography (HIC) using eight commercially available phenyl media and five model proteins (ribonuclease A, lysozyme, alpha-..
  50. doi Extension of the selection of protein chromatography and the rate model to affinity chromatography
    G Sandoval
    Centre for Biochemical Engineering and Biotechnology, Institute for Cell Dynamics and Biotechnology, University of Chile, Beauchef 850, Santiago, Chile
    J Mol Recognit 23:609-17. 2010
    ..The extension of the theory developed previously for ion-exchange and HIC chromatography to affinity separations is analyzed in this paper...
  51. ncbi Hydrophobic interaction chromatography: harnessing multivalent protein-surface interactions for purification procedures
    Herbert P Jennissen
    Department of Physiological Chemistry, University of Duisberg Essen, Germany
    Methods Mol Biol 305:81-99. 2005
    Hydrophobic interaction chromatography (HIC) is one of the basic purification procedures in the biosciences...
  52. doi Interferon-gamma and interleukin-4 single nucleotide gene polymorphisms in Paracoccidioidomycosis
    A Bozzi
    Departamento de Bioquímica e Imunologia do Instituto de Ciências Biológicas, UFMG, Caixa Postal 486, CEP 31 270 901, Belo Horizonte, MG, Brazil
    Cytokine 48:212-7. 2009
    ..IFN-gamma showed an increase occurrence of A/T genotype in both PCM patients and healthy individuals as control (HIC) (56% and 45%, respectively), while the allelic distribution showed 82% of A allele in the patients and 80% in the ..
  53. ncbi Effect of different photo-activation methods on push out force, hardness and cross-link density of resin composite restorations
    William Cunha Brandt
    Department of Restorative Dentistry, Dental Materials Division, Piracicaba Dental School, State University of Campinas, UNICAMP, Av Limeira 901, 13414 903, Piracicaba SP, Brazil
    Dent Mater 24:846-50. 2008
    ..To evaluate push out force, hardness and cross-link density (CLD) of composite restorations photo-activated by different methods...
  54. ncbi High resolution of multiple forms of rabbit reticulocyte hexokinase type I by hydrophobic interaction chromatography
    V Stocchi
    Istituto di Chimica Biologica, Giorgio Fornaini, , Italy
    J Chromatogr A 676:51-63. 1994
    Hydrophobic interaction chromatography (HIC) has been employed extensively in the separation of proteins by elution using a descending salt gradient, with and without the use of detergents or denaturing agents...
  55. ncbi Improving collaboration between private psychiatrists, the public mental health sector and general practitioners: evaluation of the Partnership Project
    Jane Pirkis
    Program Evaluation Unit, School of Population Health, University of Melbourne, Victoria 3010, Australia
    Aust N Z J Psychiatry 38:125-34. 2004
    ..The evaluation aimed to describe the impacts and outcomes of these elements...
  56. ncbi [Problems in model-beds for tuberculosis patients]
    Kunihiko Ito
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokoyo, Japan
    Kekkaku 84:9-14. 2009
    ..To investigate the possibility and obstacles to care tuberculosis patients in general hospitals...
  57. ncbi DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes
    Kiyoshi Asada
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Oncol Rep 15:1241-8. 2006
    ..DNA cytosine methylation status in the promoter CpG islands of eight cancer-related genes (p16, Socs-1, Rassf1A, Hic-1, Dlc-1, Timp-1, Timp-2, and Timp-3) in five rat hepatocyte cell lines, including normal cell lines (Clone 9 and ..
  58. ncbi [Preparation and immunogenicity of a Pichia pastoris-derived hepatitis B vaccine containing preS1, preS2 and S epitopes]
    Chang Yao Tan
    Laboratory of Biotechnology, Chengdu Institute of Biological Products, Chengdu 610023, China
    Sheng Wu Gong Cheng Xue Bao 23:700-3. 2007
    ..SSIS2 antigen was extracted and purified by silica adsorption, HIC and SEC to 99% purity from the harvested cells...
  59. pmc Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    Naoshi Nishida
    Division of Gastroenterology, Department of Internal Medicine and Charles A Sammons Cancer Center, Dallas, TX, USA
    Hepatology 47:908-18. 2008
    ..Normal liver tissues showed methylation primarily in group 1 loci (HIC-1, CASP8, GSTP1, SOCS1, RASSF1A, p16, APC), which was significantly higher than group 2 (CDH1, RUNX3, RIZ1, SFRP2, ..
  60. ncbi Hydrophobic nature of rat lymph chylomicrons
    Tayfun Güldür
    Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya 44069, Turkey
    Clin Chim Acta 342:161-9. 2004
    ..Some of the hydrophobic characteristics of rat lymph chylomicrons were investigated...
  61. doi Evaluation of the pH- and thermal stability of the recombinant green fluorescent protein (GFP) in the presence of sodium chloride
    Marina Ishii
    Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Science, University of Sao Paulo, SP, Brazil
    Appl Biochem Biotechnol 137:555-71. 2007
    ..cells by the three-phase partitioning method and purified through a butyl hydrophobic interaction chromatography (HIC) column, was diluted in water for injection (WFI) (pH 6.0-7.0) and in 10 mM buffer solutions (acetate, pH 5...
  62. ncbi Fractional precipitation of plasmid DNA from lysate by CTAB
    Russel J Lander
    Merck and Co, Inc, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Biotechnol Bioeng 79:776-84. 2002
    ..Chromatographic methods such as hydrophobic interaction chromatography (HIC), reversed phase chromatography (RPC), and size exclusion chromatography (SEC) are the only effective means of ..
  63. ncbi Cryoprotective activities of group 3 late embryogenesis abundant proteins from Chlorella vulgaris C-27
    K I Honjoh
    Department of Bioscience and Biotechnology, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 64:1656-63. 2000
    The nucleotide sequence of hiC12, isolated as a cDNA clone of hardening-induced Chlorella (hiC) genes, was identified...
  64. ncbi [A case of mixed (parenchymatous meningo-basal) neurocysticercosis]
    S Manzano Blanco
    , , Madrid,
    Rev Neurol 25:1585-8. 1997
    ..The commonest presenting symptoms are intracranial hypertension (HIC) in the extra-parenchymatous forms and convulsions in the parenchymatous forms...
  65. ncbi Hepatic iron overload in patients with chronic viral hepatitis: role of HFE gene mutations
    A Piperno
    Istituto di Scienze Biomediche, Universita di Milano, Divisione di Medicina I, Ospedale S Gerardo, Monza, Italy
    Hepatology 28:1105-9. 1998
    ..Hepatic iron was evaluated by semiquantitative analysis in all the patients, and hepatic iron concentration (HIC) was determined in 97 of them (26 women, 71 men)...
  66. doi Dynamic control of protein conformation transition in chromatographic separation based on hydrophobic interactions: molecular dynamics simulation
    Lin Zhang
    Department of Chemical Engineering, Tsinghua University, Beijing, China
    J Chromatogr A 1216:2483-90. 2009
    ..of a protein in hydrophobic interaction based chromatography, including hydrophobic interaction chromatography (HIC) and reversed-phase liquid chromatography (RPLC), and their impact on the separation process and performance were ..
  67. ncbi Steatosis is a cofactor in liver injury in hemochromatosis
    Elizabeth E Powell
    School of Medicine, The University of Queensland, Brisbane, Australia
    Gastroenterology 129:1937-43. 2005
    ....
  68. pmc Comparative performance of playground surfacing materials including conditions of extreme non-compliance
    A H Gunatilaka
    Accident Research Centre, Monash University, Melbourne, Australia
    Inj Prev 10:174-9. 2004
    ....
  69. pmc Out on a limb: risk factors for arm fracture in playground equipment falls
    S Sherker
    NSW Injury Risk Management Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Inj Prev 11:120-4. 2005
    ..To investigate and quantify fall height, surface depth, and surface impact attenuation as risk factors for arm fracture in children who fall from playground equipment...
  70. ncbi [Tumors showing perivascular epithelioid cell differentiation: a clinicopathologic study of 39 cases]
    Dong lan Luo
    Department of Pathology and Medical Laboratory, Guangdong Provincial People s Hospital, Guangzhou 510080, China
    Zhonghua Yi Xue Za Zhi 87:2909-13. 2007
    ..To investigate the clinicopathologic features of tumors showing perivascular epithelioid cell differentiation (PEComas)...
  71. ncbi Gonadotropin-releasing hormone functionally antagonizes testosterone activation of the human androgen receptor in prostate cells through focal adhesion complexes involving Hic-5
    Stuart Maudsley
    Medical Research Council Human Reproductive Sciences Unit, The Queen s Medical Research Institute, and Ardana Bioscience, Edinburgh, UK
    Neuroendocrinology 84:285-300. 2006
    ..kinase Pyk2, the non-receptor tyrosine kinase c-Src and the focal adhesion protein/steroid receptor co-factor, Hic-5...
  72. ncbi On-column refolding of consensus interferon at high concentration with guanidine-hydrochloride and polyethylene glycol gradients
    Fangwei Wang
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China
    J Chromatogr A 1115:72-80. 2006
    ..Hydrophobic interaction chromatography (HIC) was tried but a simple step-wise elution could not refold the protein...
  73. ncbi Two-step recovery process for tryptophan tagged cutinase: interfacing aqueous two-phase extraction and hydrophobic interaction chromatography
    Cecilia Kepka
    Department of Biochemistry, Centerfor Chemistry and Chemical Engineering, Lund University, P O Box 124, SE 221 00 Lund, Sweden
    J Chromatogr A 1075:33-41. 2005
    ..of a poly(ethylene glycol) (PEG)-phosphate aqueous two-phase system with hydrophobic interaction chromatography (HIC) for primary recovery of an intracellular protein was evaluated...
  74. doi The Fh8 tag: a fusion partner for simple and cost-effective protein purification in Escherichia coli
    Sofia J Costa
    IBB Institute for Biotechnology and Bioengineering, Centre of Biological Engineering, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal Instituto Nacional de Saúde Dr Ricardo Jorge INSARJ, Porto, Portugal
    Protein Expr Purif 92:163-70. 2013
    ..properties of Fh8 tag to a hydrophobic matrix were first studied via hydrophobic interaction chromatography (HIC)...
  75. ncbi Preparation of hydrophobic interaction chromatographic packings based on monodisperse poly(glycidylmethacrylate-co-ethylenedimethacrylate) beads and their application
    Bolin Gong
    Institute of Modern Separation Science, Key Laboratory of Modern Separation Science in Shaanxi Province, Northwest University, Xi an 710069, China
    J Chromatogr A 1022:33-9. 2004
    ..Based on this media, a hydrophobic interaction chromatographic (HIC) stationary phase for HPLC was synthesized by a new chemically modified method...
  76. pmc A model for 'reverse innovation' in health care
    Jacqueline W Depasse
    Director, Global Primary Care Program, Massachusetts General Hospital, Boston, MA, USA
    Global Health 9:40. 2013
    ..countries; (2) innovation and spread in the low-income country (LIC); (3) crossover to the higher-income country (HIC); and (4) innovation and spread in the HIC...
  77. doi Single step plasmid DNA purification using methacrylate monolith bearing combination of ion-exchange and hydrophobic groups
    Vida Smrekar
    JAFRAL d o o, Koprska ulica 94, 1000 Ljubljana, Slovenia
    J Chromatogr A 1276:58-64. 2013
    ..Recently, a process comprising the combination of hydrophobic interaction (HIC) monolith and ion-exchange monolith was developed...
  78. ncbi Hydrophobic interaction chromatography selectivity changes among three stable proteins: conformation does not play a major role
    Tara Tibbs Jones
    Department of Chemical Engineering, University of Virginia, 102 Engineers Way, PO Box 400741, Charlottesville, Virginia 22904 4741, USA
    Biotechnol Bioeng 87:388-99. 2004
    ..and selectivity changes have been noted for a number of proteins in hydrophobic interaction chromatography (HIC)...
  79. ncbi [Refractory arterial hypertension--where is the refractoriness? Hic rhodus, hic salta!]
    B Jelakovic
    Zavod za nefrologiju i arterijsku hipertenziju, Klinika za unutrasnje bolesti Medicinskog, fakulteta Sveucilista u Zagrebu i Klinickoga bolnickog centra Zagreb
    Lijec Vjesn 123:184-90. 2001
    ..The treatment of RH patients is a serious challenge which may unfortunately be frustrating and not infrequently have a fatal outcome due to either disease progression or patient's obstinacy...
  80. pmc Cbl-c ubiquitin ligase activity is increased via the interaction of its RING finger domain with a LIM domain of the paxillin homolog, Hic 5
    Philip E Ryan
    Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 7:e49428. 2012
    ..In this study we identify a new Cbl-c interacting protein, Hydrogen peroxide Induced Construct 5 (Hic-5)...
  81. pmc Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA
    Nicholas O Deakin
    Department of Cell and Developmental Biology, State University of New York Upstate Medical University, Syracuse, New York, United States of America
    PLoS ONE 7:e37990. 2012
    ..between the focal adhesion proteins vinculin and paxillin, as well as the closely related family member Hic-5 are spatially and reciprocally regulated by the activity of Rac1 and RhoA...
  82. doi Hic-5 affects proliferation, migration and invasion of B16 murine melanoma cells
    Fumihito Noguchi
    Department of Regenerative Dermatology, Graduate School of Medicine, Osaka University, Osaka, Japan
    Pigment Cell Melanoma Res 25:773-82. 2012
    b>Hic-5 is a shuttling protein between the cell membrane and the nucleus which functions as a focal adhesion adaptor protein and a nuclear receptor coactivator...
  83. doi Pedestrian headform testing: inferring performance at impact speeds and for headform masses not tested, and estimating average performance in a range of real-world conditions
    T Paul Hutchinson
    Centre for Automotive Safety Research, University of Adelaide, Adelaide, Australia
    Traffic Inj Prev 13:402-11. 2012
    ....
  84. doi Effects of vehicle impact velocity, vehicle front-end shapes on pedestrian injury risk
    Yong Han
    Department of Mechanical Engineering, Xiamen University of Technology, Xiamen, China
    Traffic Inj Prev 13:507-18. 2012
    ..This study aimed at investigating the effects of vehicle impact velocity, vehicle front-end shape, and pedestrian size on injury risk to pedestrians in collisions with passenger vehicles with various frontal shapes...
  85. doi Estimating medical expenditures spent on rule-out diagnoses in Japan
    Shinichi Tanihara
    Department of Hygiene and Preventive Medicine, School of Medicine, Fukuoka University, Fukuoka, Japan
    J Eval Clin Pract 18:426-32. 2012
    ..scheme in Japan's health insurance system, rule-out diagnoses must be included in a health insurance claim (HIC) to ensure reimbursement for clinical procedures whose results show that a suspected disease is not present...
  86. doi Biomechanical impact response of the human chin and manubrium
    Jason A Stammen
    National Highway Traffic Safety Administration, East Liberty, OH, USA
    Ann Biomed Eng 40:666-78. 2012
    ..HYGE sled crash simulation tests, and these contact forces were strongly correlated with the Head Injury Criterion (HIC(36 ms))...
  87. pmc The potential for brain injury on selected surfaces used by cheerleaders
    Brenda J Shields
    Center for Injury Research and Policy, The Research Institute at Nationwide Children s Hospital, 700 Children s Drive, Columbus, OH 43205, USA
    J Athl Train 44:595-602. 2009
    ..Although playground surfaces have been investigated for fall impact attenuation, the surfaces that cheerleaders use have received little attention...
  88. ncbi Potassium channels as targets for ethanol: studies of G-protein-coupled inwardly rectifying potassium channel 2 (GIRK2) null mutant mice
    Y A Blednov
    Waggoner Center for Alcohol and Addiction Research and Section of Neurobiology, University of Texas at Austin, Texas 78712 1095, USA
    J Pharmacol Exp Ther 298:521-30. 2001
    ..cage (habituated) motor activity, anxiolytic action in elevated-plus maze test, and handling-induced convulsions (HIC) after an acute injection of ethanol...
  89. pmc Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae
    Ying Lin
    Department of Chemistry and Biochemistry, University of Oklahoma, 620 Parrington Oval, Norman, Oklahoma 73018, USA
    Biochemistry 48:7305-12. 2009
    ..by approximately 2400- and approximately 680-fold, respectively, compared to that of wild-type HIcDH; the K(m) for HIc does not change significantly...
  90. pmc Expression of the Hypermethylated in Cancer gene (HIC-1) is associated with good outcome in human breast cancer
    G Nicoll
    Department of Surgery and Molecular Oncology, University of Dundee, Dundee DD1 9SY, UK
    Br J Cancer 85:1878-82. 2001
    A new cancer gene, HIC-1 (Hypermethylated in Cancer) telomeric to p53 on chromosome 17p may be of clinical importance in sporadic breast cancer. Regional DNA hypermethylation of 17p13...
  91. ncbi Allelic variation in the highly polymorphic locus pspC of Streptococcus pneumoniae
    Francesco Iannelli
    Laboratory of Molecular Microbiology and Biotechnology, Sezione di Microbiologia, Dipartimento di Biologia Molecolare, Universita di Siena, 53100, Siena, Italy
    Gene 284:63-71. 2002
    PspC, also called SpsA, CbpA, PbcA, and Hic, is a surface protein of Streptococcus pneumoniae studied for its antigenic properties, its capability to bind secretory IgA, C3 and complement factor H, and its activity as an adhesin...
  92. doi Impact of curing protocol on the selected properties of a model bis-GMA/TEGDMA dental resin composite
    Murilo B Lopes
    Department of Restorative Dentistry, School of Dentistry, North of Paraná University, Rua Marselha, 183, 86041 140 Londrina, PR, Brazil
    Biomed Mater 4:025014. 2009
    ..The protocols tested were: high-intensity continuous (HIC-500 mW cm(-2) for 20 s), medium-intensity continuous (MIC-250 mW cm(-2) for 40 s), low-intensity continuous (LIC-..
  93. doi Assessment of COMT isolation by HIC using a dual salt system and low temperature
    V S Nunes
    CICS Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, 6201 001 Covilha, Portugal
    Biomed Chromatogr 24:858-62. 2010
    ..dual salt system, ammonium sulfate (AS) and SC on binding and elution conditions of recombinant hSCOMT on typical HIC sorbents...
  94. ncbi Chronic hepatitis C: hepatic iron content does not correlate with response to antiviral therapy
    Patricia da Silva Fucuta Pereira
    Division of Gastroenterology, Hepatitis Section, Federal University of Sao Paulo, SP, Sao Paulo, Brazil
    Rev Inst Med Trop Sao Paulo 51:331-6. 2009
    ..The aim of this study was to evaluate the influence of hepatic iron concentration (HIC) on the sustained virological response (SVR) to antiviral therapy in patients with chronic hepatitis C...
  95. pmc Expression of focal adhesion proteins in the developing rat kidney
    Sato Matsuura
    Department of Pediatrics, Institute of Health Bioscience, The University of Tokushima Graduate School, Tokushima, Japan
    J Histochem Cytochem 59:864-74. 2011
    ..Focal adhesion kinase (FAK), paxillin, integrin-linked kinase (ILK), and hydrogen peroxide-inducible clone-5 (Hic-5) are major proteins that contribute to these events...
  96. ncbi Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin
    S M Thomas
    Department of Medicine, Cancer Biology Program, Beth Israel Deaconess Medical Center Harvard Medical School, Boston, MA 02215, USA
    J Cell Sci 112:181-90. 1999
    ..Two alternatively spliced mouse paxillin cDNAs were cloned and in the process, a paxillin-related protein, Hic-5, was also identified...
  97. pmc Transforming growth factor-β1-induced transcript 1 protein, a novel marker for smooth muscle contractile phenotype, is regulated by serum response factor/myocardin protein
    Xiaobo Wang
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York 12208, USA
    J Biol Chem 286:41589-99. 2011
    ..Previous studies have shown that transforming growth factor-β1-induced transcript 1 (TGFB1I1, also known as Hic-5) is a TGF-β-responsive gene and is involved in the cellular response to vascular injury, but the regulation of ..
  98. doi Effect of mouthguards on head responses and mandible forces in football helmet impacts
    David C Viano
    ProBiomechanics LLC, 265 Warrington Rd, Bloomfield Hills, MI 48304 2952, USA
    Ann Biomed Eng 40:47-69. 2012
    ..In phase 1, one of five mouthguards significantly lowered HIC in 6.7 m/s impacts (p = 0.025) from the no mouthguard condition but not in 9.5 m/s tests...
  99. doi Solubility and binding properties of PEGylated lysozyme derivatives with increasing molecular weight on hydrophobic-interaction chromatographic resins
    Egbert Müller
    Tosoh Bioscience GmbH, Stuttgart, Germany
    J Chromatogr A 1217:4696-703. 2010
    ..derivatives with varying molecular weights of poly (ethylene) glycol (PEG) with 5 kDa, 10 kDa and 30 kDa for HIC resins and columns are presented...
  100. ncbi Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain
    N Nishiya
    Department of Microbiology, Showa University School of Pharmaceutical Sciences, Hatanodai 1 5 8, Shinagawa ku, Tokyo, Japan
    J Biol Chem 274:9847-53. 1999
    The Hic-5 protein is encoded by a transforming growth factor-beta1- and hydrogen peroxide-inducible gene, hic-5, and has striking similarity to paxillin, especially in their C-terminal LIM domains...
  101. doi Impact performance of modern football helmets
    David C Viano
    ProBiomechanics LLC, 265 Warrington Rd, Bloomfield Hills, MI 48304, USA
    Ann Biomed Eng 40:160-74. 2012
    ..with an array of 3-2-2-2 accelerometers to determine translational acceleration, rotational acceleration, and HIC. Twenty-three (23) different impacts were conducted on four identical helmets of each model at eight sites on the ..

Research Grants69

  1. METHYLATION OF THE CALCITONIN GENE IN HUMAN TUMORS
    Stephen Baylin; Fiscal Year: 2007
    ..In the first specific aim, we have created a mouse knockout model for HIC-1 (Hypermethylated-in-Cancer-1), a gene cloned by screening for hypermethylated loci in a frequent LOH area for ..
  2. Alkylammonium Formate Mobile Phase Modifiers for Protein Liquid Chromatography
    NEIL DANIELSON; Fiscal Year: 2007
    ..Both reversed phase LC and hydrophobic interaction chromatography (HIC) of proteins will be characterized using MAF and EAF as mobile phase modifiers and improved resolution particularly ..
  3. Massive Iron Deposit Assessment (MIDAS)
    CLAUDIA M contact HILLENBRAND; Fiscal Year: 2010
    ..via its effect on tissue relaxation properties, have been used to noninvasively measure hepatic iron concentration (HIC)...
  4. Room Temp Susceptometry For Hepatic Iron Measurement
    Kris Kowdley; Fiscal Year: 2006
    ..At present, biochemical measurement of hepatic iron concentration (HIC) is considered the most sensitive method for clinical assessment of iron overload...
  5. Matrix & Lysolipids Regulate Endothelial Cell Migration
    TRACEE PANETTI; Fiscal Year: 2006
    ..We demonstrated that recruitment of Hic-5 is a critical difference between migrating BPAE cells attached to gelatin and non-migrating BPAE cells attached ..
  6. INTRACELLULAR MECHANISMS OF GLUCOCORTICOID ACTION
    Donald Defranco; Fiscal Year: 2005
    ..Furthermore, HIC-5 does not appear to be restricted to focal adhesions, as a fraction has been localized to the nuclear matrix...
  7. STRUCTURE AND FUNCTION OF PAXILLIN
    Christopher Turner; Fiscal Year: 2009
    ..b>Hic-5, a close relative of paxillin is upregulated during epithelial-mesenchymal transition to promote cell migration ..
  8. STRUCTURE AND FUNCTION OF PAXILLIN
    Christopher E Turner; Fiscal Year: 2010
    ..b>Hic-5, a close relative of paxillin is upregulated during epithelial-mesenchymal transition to promote cell migration ..
  9. TUMOR SUPPRESSOR GENE METHYLATION IN LUNG ADENOCARCINOMA
    Steven Belinsky; Fiscal Year: 2002
    ..The four TSGs selected p16, ER, HIC-1, and E-cadherin, are all inactivated by methylation and involved in adenocarcinoma...
  10. Regulation of Podocyte Structure by the Binding Protein
    William Smoyer; Fiscal Year: 2006
    ..of this protection, we screened a glomerular yeast two-hybrid library for hsp27-binding proteins, and found hic-5, a known focal adhesion and steroid receptor co-activator protein...
  11. EBV EXPRESSION IN NASOPHARYNGEAL CARCINOMA
    Nancy Raab Traub; Fiscal Year: 2009
    ..used two hybrid analysis with one of the BART ORFs, RK-BARF0, and determined that RK-BARF0 interacts with Notch, HIC, epithelin, and scramblase...
  12. Regulation of HIV transcription by Tat and P-TEPb
    TSAFI PE ERY; Fiscal Year: 2004
    ..in HIV-1 latency and reactivation, and to investigate the regulation of these proteins by the cellular factors HIC and granulin...
  13. Hypoxia-induced Endothelial Barrier Dysfunction
    Usamah Kayyali; Fiscal Year: 2009
    ..through the p38 MAP kinase pathway involving MK2 and HSP27 activation that leads to actin cytoskeleton and hic-5 redistribution...
  14. Roles for HIC1 in neural development and tumor suppression
    DAVID NEIL WATKINS; Fiscal Year: 2010
    ..that HIC1 is a transcriptional represser required for neural differentiation, and (2) epigenetic silencing of the HIC-1 plays a critical role in the development of medulloblastoma...
  15. Roles for HIC1 in neural development and tumor suppression
    David Watkins; Fiscal Year: 2007
    ..that HIC1 is a transcriptional represser required for neural differentiation, and (2) epigenetic silencing of the HIC-1 plays a critical role in the development of medulloblastoma...
  16. ALCOHOL PREDISPOSITION: COMPARATIVE WITHDRAWAL SYNDROMES
    John Belknap; Fiscal Year: 1992
    ..lines of mice which have been selectively-bred for either increased or decreased handling- induced convulsions (HIC) following withdrawal from ethanol (WSP and WSR lines)...
  17. Proteomic /Genetic Approaches to Monoamine Transporters
    Gonzalo Torres; Fiscal Year: 2007
    ..Aim II: To elucidate the physiological role of PICK1 and Hic-5 in the regulation of DAT function using genetic approaches...
  18. PHOSPHOENOLPYRUVATE--GLYCOSE PHOSPHOTRANSFERASE SYSTEM
    Saul Roseman; Fiscal Year: 2000
    ..We have now constructed 15 crr (HIC*) mutants, and these will be used to further probe interactions between this key regulatory molecule and P-BPr, and ..
  19. Effect of HIV Tat on endothelial cell function
    Lance Terada; Fiscal Year: 2007
    ..A secondary screen for TRAF4-interacting proteins yielded the Proline-rich Tyrosine Kinase-2 (Pyk2)scaffold Hic-5...
  20. MOLECULAR MECHANISMS CONTROLLING PROGRAMMED CELL DEATH
    Lawrence Schwartz; Fiscal Year: 2003
    ..Ectopic expression of DALP, or its mammalian paralog Hic-5, blocks differentiation and induces apoptosis in mouse C2Ct2 myoblasts...
  21. Creation of a PDGF-C Autocrine Loop by HIC1 Inactivation
    Brian Rood; Fiscal Year: 2007
    ..the importance of chromosome 17p deletion and epigenetic inactivation in the silencing of the tumor suppressor gene HIC-1 in medulloblastoma...