Gene Symbol: HYAL1
Description: hyaluronoglucosaminidase 1
Alias: HYAL-1, LUCA1, MPS9, NAT6, hyaluronidase-1, luCa-1, lung carcinoma protein 1, plasma hyaluronidase, tumor suppressor LUCA-1
Species: human
Products:     HYAL1

Top Publications

  1. Frost G, Csoka A, Wong T, Stern R, Csóka T. Purification, cloning, and expression of human plasma hyaluronidase. Biochem Biophys Res Commun. 1997;236:10-5 pubmed
    ..matched a cDNA in the Expressed Sequence Tag database which, with 5'-RACE-PCR, was used to clone the plasma hyaluronidase gene, termed Hyal-1...
  2. Frost G, Mohapatra G, Wong T, Csoka A, Gray J, Stern R. HYAL1LUCA-1, a candidate tumor suppressor gene on chromosome 3p21.3, is inactivated in head and neck squamous cell carcinomas by aberrant splicing of pre-mRNA. Oncogene. 2000;19:870-7 pubmed
    The hyaluronidase first isolated from human plasma, Hyal-1, is expressed in many somatic tissues. The Hyal-1 gene, HYAL1, also known as LUCA-1, maps to chromosome 3p21...
  3. Franzmann E, Schroeder G, Goodwin W, Weed D, Fisher P, Lokeshwar V. Expression of tumor markers hyaluronic acid and hyaluronidase (HYAL1) in head and neck tumors. Int J Cancer. 2003;106:438-45 pubmed
    ..Reverse transcriptase (RT)-PCR analysis detected the expression of full-length HYAL1 type HAase transcript in tumor cells. None of the cells exhibited the expression of PH20 in RT-PCR analysis...
  4. Harada H, Takahashi M. CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2. J Biol Chem. 2007;282:5597-607 pubmed
    ..Based on these findings, Hyal-1 and -2 contribute to intracellular and extracellular catabolism of HA, respectively, in a CD44-dependent manner, and their HA degradation occurs independently from one another. ..
  5. Kramer M, Golshani R, Merseburger A, Knapp J, Garcia A, Hennenlotter J, et al. HYAL-1 hyaluronidase: a potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer. Eur Urol. 2010;57:86-93 pubmed publisher
    ..001; 76.8% accuracy) and recurrence (p=0.01; 67.8% accuracy). HYAL-1 is a potential prognostic marker for predicting progression to muscle invasion and recurrence. ..
  6. Nykopp T, Rilla K, Sironen R, Tammi M, Tammi R, Hamalainen K, et al. Expression of hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in serous ovarian carcinomas: inverse correlation between HYAL1 and hyaluronan content. BMC Cancer. 2009;9:143 pubmed publisher
    ..of hyaluronan, we examined the expression of hyaluronan synthases (HAS1, HAS2 and HAS3) and hyaluronidases (HYAL1 and HYAL2), correlated with hyaluronidase enzyme activity hyaluronan content and HAS1-3 immunoreactivity...
  7. Wang X, Tan J, Vasse M, Delpech B, Ren G. Comparison of hyaluronidase expression, invasiveness and tubule formation promotion in ER (-) and ER (+) breast cancer cell lines in vitro. Chin Med J (Engl). 2009;122:1300-4 pubmed
  8. Berdiaki A, Nikitovic D, Tsatsakis A, Katonis P, Karamanos N, Tzanakakis G. bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells. Biochim Biophys Acta. 2009;1790:1258-65 pubmed publisher
    ..bFGF regulates, in a cell-specific manner the migration capability of fibrosarcoma cells by modulating their HA metabolism. HA metabolism is suggested to be a potential therapeutic target in fibrosarcoma. ..
  9. Tan J, Wang X, Li H, Su X, Wang L, Ran L, et al. HYAL1 overexpression is correlated with the malignant behavior of human breast cancer. Int J Cancer. 2011;128:1303-15 pubmed publisher
    ..Levels of HAase are elevated in many cancers. Hyaluronidase-1 (HYAL1) is the major tumor-derived HAase...

More Information

Publications108 found, 100 shown here

  1. Csoka A, Frost G, Wong T, Stern R, Csóka T. Purification and microsequencing of hyaluronidase isozymes from human urine. FEBS Lett. 1997;417:307-10 pubmed
    ..Microsequencing confirmed that both urinary isozymes have N-termini identical to plasma hyaluronidase, but a second N-terminus was found in the smaller isozyme, apparently derived from the terminal 25 amino ..
  2. Rai S, Duh F, Vigdorovich V, Danilkovitch Miagkova A, Lerman M, Miller A. Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation. Proc Natl Acad Sci U S A. 2001;98:4443-8 pubmed
    ..HYAL2, whereas we could easily detect such activity from cells expressing the related serum hyaluronidase HYAL1. Although the function of HYAL2 is currently unknown, other GPI-anchored proteins are involved in signal ..
  3. Junker N, Latini S, Petersen L, Kristjansen P. Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines. Oncol Rep. 2003;10:609-16 pubmed
    ..Three hyaluronidases, HYAL1, HYAL2 and HYAL3, are located at the chromosomal region 3p21...
  4. Christopoulos T, Papageorgakopoulou N, Theocharis D, Mastronikolis N, Papadas T, Vynios D. Hyaluronidase and CD44 hyaluronan receptor expression in squamous cell laryngeal carcinoma. Biochim Biophys Acta. 2006;1760:1039-45 pubmed
    ..aberrant expression of PH-20, the testicular-type hyaluronidase, at late stages of cancer and an overexpression of HYAL1 only at stage IV. In addition, CD44 was identified in two protein bands of 80 and 64 kDa in cancer samples...
  5. Tan J, Ren G, Tu G, Li X, Wang X, Ran L. [Effect of silencing of hyaluronidase gene HYAL1 by RNA interference on proliferation of human breast cancer cells]. Ai Zheng. 2006;25:844-8 pubmed
    ..This study was to investigate whether HYAL1 RNA interference (RNAi) could effectively inhibit gene mRNA expression as well as cell proliferation in human ..
  6. Lokeshwar V, Gomez P, Kramer M, Knapp J, McCornack M, Lopez L, et al. Epigenetic regulation of HYAL-1 hyaluronidase expression. identification of HYAL-1 promoter. J Biol Chem. 2008;283:29215-27 pubmed publisher
    ..Thus, HYAL-1 expression is epigenetically regulated by the binding of different transcription factors to the methylated and unmethylated HYAL-1 promoter. ..
  7. Wang F, Grigorieva E, Li J, Senchenko V, Pavlova T, Anedchenko E, et al. HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro. PLoS ONE. 2008;3:e3031 pubmed publisher
    ..The effect of expression HYAL1 and HYAL2 was studied by colony formation inhibition, growth curve and cell proliferation tests in vitro and ..
  8. Nykopp T, Rilla K, Tammi M, Tammi R, Sironen R, Hamalainen K, et al. Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma. BMC Cancer. 2010;10:512 pubmed publisher
    ..we examined the expression levels of the hyaluronan synthases (HAS1, HAS2 and HAS3) and hyaluronidases (HYAL1 and HYAL2), and correlated them with hyaluronan content and HAS1-3 immunoreactivity...
  9. Addotey J, Lengers I, Jose J, Hensel A. Hyal-1 inhibitors from the leaves of Phyllanthus muellerianus (Kuntze) Excell. J Ethnopharmacol. 2019;236:326-335 pubmed publisher
    ..muellerianus is justified, rather than the use of the isolated tannins. The traditional use of the plant as an anti-inflammatory agent for improved wound-healing can be rationalized by the anti-Hyal-1 activities of its constituents. ..
  10. de Sá V, Carvalho L, Gomes A, Alarcão A, Silva M, Couceiro P, et al. Role of the extracellular matrix in variations of invasive pathways in lung cancers. Braz J Med Biol Res. 2013;46:21-31 pubmed
    ..Therefore, our findings suggest that strategies aimed at preventing high HAS-3 and Hyal-1 synthesis, or local responses to low TGF-β and E-cadherin, may have a greater impact in lung cancer prognosis. ..
  11. Liu M, Du H, Khan A, Ji J, Yu A, Zhai G. Redox/enzyme sensitive chondroitin sulfate-based self-assembled nanoparticles loading docetaxel for the inhibition of metastasis and growth of melanoma. Carbohydr Polym. 2018;184:82-93 pubmed publisher
    ..With only minor cytotoxicity, CSCD nanoparticles could be promising nano-drug delivery systems for successful management of melanoma. ..
  12. Yoshino Y, Ishisaka M, Tsuruma K, Shimazawa M, Yoshida H, Inoue S, et al. Distribution and function of hyaluronan binding protein involved in hyaluronan depolymerization (HYBID, KIAA1199) in the mouse central nervous system. Neuroscience. 2017;347:1-10 pubmed publisher
    ..In real-time PCR, Hyal1 and Hyal2 mRNA levels, which code hyaluronidases 1 and 2, respectively, did not differ between the Hybid KO and ..
  13. Gatti V, Fierro C, Compagnone M, Giangrazi F, Markert E, Bongiorno Borbone L, et al. ΔNp63 regulates the expression of hyaluronic acid-related genes in breast cancer cells. Oncogenesis. 2018;7:65 pubmed publisher
    ..Importantly, high HAS3 expression is a negative prognostic factor of TNBC patients. Our data suggest that in basal-type breast carcinoma ∆Np63 might favor a HA-rich microenviroment, which can sustain tumor proliferation and stemness. ..
  14. Wypchło M, Korwin Kossakowska A, Bereznowski A, Hecold M, Lewczuk D. Polymorphisms in selected genes and analysis of their relationship with osteochondrosis in Polish sport horse breeds. Anim Genet. 2018;49:623-627 pubmed publisher
    ..Seven SNPs located in the MATN1, CPVL, HYAL1, XIRP2, FRZB, COL5A2 and IGF1 genes were found to be associated with occurrence of osteochondrotic lesions in ..
  15. Mammadov E, Aslan G, Tuna B, Bozkurt O, Yorukoglu K. Can recurrence and progression be predicted by HYAL-1 expression in primary T1 bladder cancer?. Asian Pac J Cancer Prev. 2014;15:10401-5 pubmed
    ..HYAL-1 expression did not have any prognostic value in estimating recurrence or progression. HYAL-1 expression was found to be high, but did not have any prognostic importance in T1 bladder urothelial carcinomas. ..
  16. Krishnamurthy V, Stout A, Sapp M, Matuska B, Lauer M, Grande Allen K. Dysregulation of hyaluronan homeostasis during aortic valve disease. Matrix Biol. 2017;62:40-57 pubmed publisher
    ..Pathological heavy chain HA together with abnormal regional expression of the enzymes HAS2, HYAL1, KIAA1199, TSG6 and I?I was demonstrated in calcified valve tissues identifying the collapse of HA homeostatic ..
  17. Liu M, Khan A, Ji J, Lin G, Zhao X, Zhai G. Crosslinked self-assembled nanoparticles for chemo-sonodynamic combination therapy favoring antitumor, antimetastasis management and immune responses. J Control Release. 2018;290:150-164 pubmed publisher
    ..Our work thus presents a convenient approach to fabricate intelligent multifunctional nanoparticles and paves a path for effective cancer therapies. ..
  18. Colombaro V, Jadot I, Declèves A, Voisin V, Giordano L, Habsch I, et al. Lack of hyaluronidases exacerbates renal post-ischemic injury, inflammation, and fibrosis. Kidney Int. 2015;88:61-71 pubmed publisher
    ..Here we tested whether Hyal1-/- and Hyal2-/- mice display exacerbated renal damage following unilateral IRI due to a higher HA accumulation in ..
  19. Nikitovic D, Berdiaki A, Galbiati V, Kavasi R, Papale A, Tsatsakis A, et al. Hyaluronan regulates chemical allergen-induced IL-18 production in human keratinocytes. Toxicol Lett. 2015;232:89-97 pubmed publisher
    ..This is the first indication that LMWHA can act as a DAMP in keratinocytes. In conclusion LMWHA fragments are important mediators in the process of contact sensitisation leading to IL-18 dependent responses. ..
  20. Mehić M, de Sá V, Hebestreit S, Heldin C, Heldin P. The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function. Oncogenesis. 2017;6:e348 pubmed publisher
    ..is balanced through the actions of hyaluronan-synthesizing enzymes (HAS1, 2 and 3) and degrading hyaluronidases (Hyal 1, 2, 3 and PH20)...
  21. Nasioudis D, Beghini J, Bongiovanni A, Giraldo P, Linhares I, Witkin S. α-Amylase in Vaginal Fluid: Association With Conditions Favorable to Dominance of Lactobacillus. Reprod Sci. 2015;22:1393-8 pubmed publisher
    ..Concomitant production of NGAL and SLPI would retard growth of BV-related bacteria. ..
  22. McAtee C, Booth C, Elowsky C, Zhao L, Payne J, Fangman T, et al. Prostate tumor cell exosomes containing hyaluronidase Hyal1 stimulate prostate stromal cell motility by engagement of FAK-mediated integrin signaling. Matrix Biol. 2018;: pubmed publisher
    The hyaluronidase Hyal1 is clinically and functionally implicated in prostate cancer progression and metastasis...
  23. Nieuwdorp M, Holleman F, de Groot E, Vink H, Gort J, Kontush A, et al. Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis. Diabetologia. 2007;50:1288-93 pubmed
    ..These data may lend further support to altered glycosaminoglycan metabolism in type 1 diabetes as a potential mechanism involved in accelerated atherogenesis. ..
  24. Pelch K, Tokar E, Merrick B, Waalkes M. Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium. Toxicol Appl Pharmacol. 2015;286:159-67 pubmed publisher
    ..Of the most highly dysregulated genes, five genes that can be relevant to the carcinogenic process (S100P, HYAL1, NTM, NES, ALDH1A1) were chosen for an in-depth analysis of the DNA methylation profile...
  25. Colombaro V, Jadot I, Declèves A, Voisin V, Giordano L, Habsch I, et al. Hyaluronidase 1 and hyaluronidase 2 are required for renal hyaluronan turnover. Acta Histochem. 2015;117:83-91 pubmed publisher
    b>Hyaluronidase 1 (HYAL1) and hyaluronidase 2 (HYAL2) are the major hyaluronidases acting synergistically to degrade hyaluronan (HA). In the kidney, HA is distributed heterogeneously...
  26. Dogne S, Flamion B, Caron N. Endothelial Glycocalyx as a Shield Against Diabetic Vascular Complications: Involvement of Hyaluronan and Hyaluronidases. Arterioscler Thromb Vasc Biol. 2018;38:1427-1439 pubmed publisher
    ..The amount of HA in the EG may be regulated by HYAL (hyaluronidase) 1, the most active somatic hyaluronidase. HYAL1 seems enriched in endothelial cells through endocytosis from the bloodstream...
  27. Maksimenko A, Turashev A, Beabealashvili R. Stratification of chondroitin sulfate binding sites in 3D-model of bovine testicular hyaluronidase and effective size of glycosaminoglycan coat of the modified protein. Biochemistry (Mosc). 2015;80:284-95 pubmed publisher
    ..testicular hyaluronidase (BTH) was constructed based on established tertiary structure of human hyaluronidase Hyal1 using a molecular homological modeling method in silico...
  28. Addotey J, Lengers I, Jose J, Gampe N, Beni S, Petereit F, et al. Isoflavonoids with inhibiting effects on human hyaluronidase-1 and norneolignan clitorienolactone B from Ononis spinosa L. root extract. Fitoterapia. 2018;130:169-174 pubmed publisher
    ..Thus, a possible explanation for diuretic properties of Ononis spinosa L. root extract may be postulated from the results so far obtained. ..
  29. Qiu L, Zhang W, Wang S, Zhang X, Zhao Y, Cao L, et al. Construction of multifunctional porous silica nanocarriers for pH/enzyme-responsive drug release. Mater Sci Eng C Mater Biol Appl. 2017;81:485-491 pubmed publisher
    ..The obtained ZnO/HA-gated pSiO2 delivery system would achieve minimized premature release and responsive release under a physiological environment. ..
  30. Xin Y, Hao M, Fan G, Zhang Y, Zheng M, Zhang L. Affinity adsorption of bovine hyaluronidase with ligands targeting to active site. J Chromatogr B Analyt Technol Biomed Life Sci. 2018;1092:422-431 pubmed publisher
    ..2 and 96.4%; the bioactivity recoveries were 83.5 and 89.4%. In addition, the bands on SDS-PAGE gel were also extracted and confirmed with linear trap quadropole mass spectrometry (LTQ-MS) analysis. ..
  31. Tzuman Y, Sapoznik S, Granot D, Nevo N, Neeman M. Peritoneal adhesion and angiogenesis in ovarian carcinoma are inversely regulated by hyaluronan: the role of gonadotropins. Neoplasia. 2010;12:51-60 pubmed
    ..Accordingly, angiogenesis of the adhered spheroids was significantly elevated in DON-treated tumors. These results can explain the selective pressure that can lead to simultaneously increased tumor expression of both HASs and Hyals...
  32. Midgley A, Duggal L, Jenkins R, Hascall V, Steadman R, Phillips A, et al. Hyaluronan regulates bone morphogenetic protein-7-dependent prevention and reversal of myofibroblast phenotype. J Biol Chem. 2015;290:11218-34 pubmed publisher
    ..In addition, we identify Hyal2 and CD44v7/8 as new potential targets for manipulation in prevention and reversal of fibrotic pathology. ..
  33. McAtee C, Berkebile A, Elowsky C, Fangman T, Barycki J, Wahl J, et al. Hyaluronidase Hyal1 Increases Tumor Cell Proliferation and Motility through Accelerated Vesicle Trafficking. J Biol Chem. 2015;290:13144-56 pubmed publisher
    ..To determine the mechanism, we overexpressed hyaluronidase 1 (Hyal1) as a fluorescent fusion protein and examined its impact on endocytosis and vesicular trafficking...
  34. Schmaus A, Sleeman J. Hyaluronidase-1 expression promotes lung metastasis in syngeneic mouse tumor models without affecting accumulation of small hyaluronan oligosaccharides in tumor interstitial fluid. Glycobiology. 2015;25:258-68 pubmed publisher
    ..hyaluronan, a glycosaminoglycan component of the extracellular matrix, and hyaluronidases such as hyaluronidase-1 (Hyal1) that degrade hyaluronan have both been linked to poor prognosis and metastasis, suggesting that the turnover of ..
  35. Wu M, Cao M, He Y, Liu Y, Yang C, Du Y, et al. A novel role of low molecular weight hyaluronan in breast cancer metastasis. FASEB J. 2015;29:1290-8 pubmed publisher
    ..higher LMW-HA level was accompanied by the overexpression of hyaluronan synthase (HAS2) and hyaluronidase (both HYAL1 and HYAL2)...
  36. Binsila K, Selvaraju S, Ghosh S, Parthipan S, Archana S, Arangasamy A, et al. Isolation and enrichment of putative spermatogonial stem cells from ram (Ovis aries) testis. Anim Reprod Sci. 2018;196:9-18 pubmed publisher
    ..The enzyme combinations suitable for isolation of putative SSCs from prepubertal testis are different from adult ram testis and the laminin has been found to be effective for purification of putative SSCs from testicular cells isolates. ..
  37. Puissant E, Boonen M. Monocytes/Macrophages Upregulate the Hyaluronidase HYAL1 and Adapt Its Subcellular Trafficking to Promote Extracellular Residency upon Differentiation into Osteoclasts. PLoS ONE. 2016;11:e0165004 pubmed publisher
    ..Here we report that the acid hydrolase HYAL1, a hyaluronidase able to degrade the glycosaminoglycans hyaluronic acid (HA) and chondroitin sulfate, is also ..
  38. Shimizu H, Shimoda M, Mochizuki S, Miyamae Y, Abe H, Chijiiwa M, et al. Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization Is Up-Regulated and Involved in Hyaluronan Degradation in Human Osteoarthritic Cartilage. Am J Pathol. 2018;188:2109-2119 pubmed publisher
    ..These data are the first to demonstrate that HYBID is up-regulated in OA cartilage, and suggest that tumor necrosis factor ?-stimulated HYBID plays a role in HA degradation in OA cartilage. ..
  39. Saito N, Adachi H, Tanaka H, Nakata S, Kawada N, Oofusa K, et al. Interstitial fluid flow-induced growth potential and hyaluronan synthesis of fibroblasts in a fibroblast-populated stretched collagen gel culture. Biochim Biophys Acta Gen Subj. 2017;1861:2261-2273 pubmed publisher
    ..synthase 2 (HAS2) and matrix metalloprotease 1 (MMP1) gene expressions but not of the other genes (MMP2, HYAL1, HYAL2, HYAL3, COL1A1, COL3A1, and CD44)...
  40. Lokeshwar V, Mirza S, Jordan A. Targeting hyaluronic acid family for cancer chemoprevention and therapy. Adv Cancer Res. 2014;123:35-65 pubmed publisher
    ..This review discusses basic and clinical translational aspects of targeting each HA family member and respective treatment approaches that have been described in the literature. ..
  41. Raspollini M, Luque R, Menéndez C, Bollito E, Brunelli M, Martignoni G, et al. T1 high-grade bladder carcinoma outcome: the role of p16, topoisomerase-II?, survivin, and E-cadherin. Hum Pathol. 2016;57:78-84 pubmed publisher
  42. Jokela T, Kärnä R, Rauhala L, Bart G, Pasonen Seppänen S, Oikari S, et al. Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis. J Biol Chem. 2017;292:4861-4872 pubmed publisher
    ..i>HAS2 expression, although the other hyaluronan synthases (HAS1, HAS3) and hyaluronidases (HYAL1, HYAL2) were not affected...
  43. Orlando Z, Lengers I, Melzig M, Buschauer A, Hensel A, Jose J. Autodisplay of Human Hyaluronidase Hyal-1 on Escherichia coli and Identification of Plant-Derived Enzyme Inhibitors. Molecules. 2015;20:15449-68 pubmed publisher
    ..4 and 1.7 mg/mL. In summary, Autodisplay enabled the expression of functional human target protein Hyal-1 in E. coli and facilitated an accelerated testing of potential inhibitors. ..
  44. Chen X, Liu Z. A pH-Responsive Hydrogel Based on a Tumor-Targeting Mesoporous Silica Nanocomposite for Sustained Cancer Labeling and Therapy. Macromol Rapid Commun. 2016;37:1533-9 pubmed publisher
    ..All these properties have distinct benefits for tumor treatment, demonstrating that this device is a promising candidate for oncotherapy applications. ..
  45. Yamamoto H, Tobisawa Y, Inubushi T, Irie F, Ohyama C, Yamaguchi Y. A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase. J Biol Chem. 2017;292:7304-7313 pubmed publisher
    ..b>HYAL1 and HYAL2 have properties more consistent with lysosomal hyaluronidases, whereas CEMIP/KIAA1199, a recently ..
  46. Bourguignon V, Flamion B. Respective roles of hyaluronidases 1 and 2 in endogenous hyaluronan turnover. FASEB J. 2016;30:2108-14 pubmed publisher
    ..HA was localized and quantified using HA binding proteins in various tissues of Hyal1(-/-) and Hyal2(-/-) mice (knockout mice) as well as control mice...
  47. Zhang Q, Gou W, Wang X, Zhang Y, Ma J, Zhang H, et al. Genome Resequencing Identifies Unique Adaptations of Tibetan Chickens to Hypoxia and High-Dose Ultraviolet Radiation in High-Altitude Environments. Genome Biol Evol. 2016;8:765-76 pubmed publisher
    ..in the development of cardiorespiratory system (FGFR1, CTGF, ADAM9, JPH2, SATB1, BMP4, LOX, LPR, ANGPTL4, and HYAL1), inflammation and immune responses (AIRE, MYO1F, ZAP70, DDX60, CCL19, CD47, JSC, and FAS), DNA repair, and ..
  48. Dogne S, Rath G, Jouret F, Caron N, Dessy C, Flamion B. Hyaluronidase 1 Deficiency Preserves Endothelial Function and Glycocalyx Integrity in Early Streptozotocin-Induced Diabetes. Diabetes. 2016;65:2742-53 pubmed publisher
    ..Endocytosed hyaluronidase HYAL1 is known to degrade HA into small fragments in different cell types, including endothelial cells...
  49. Huang C, Liu H, Gong X, Wen B, Chen D, Liu J, et al. Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis. Mol Med Rep. 2016;14:2555-65 pubmed publisher
    ..These observations may be useful for early diagnosis of colorectal cancer. ..
  50. Deschrevel B, Lenormand H, Tranchepain F, Levasseur N, Asteriou T, Vincent J. Hyaluronidase activity is modulated by complexing with various polyelectrolytes including hyaluronan. Matrix Biol. 2008;27:242-53 pubmed
    ..Finally, the extent of such non-specific interactions between polyelectrolytes and proteins in HAase inhibition or activation, in particular under in vivo conditions, is discussed. ..
  51. Mohey Elsaeed O, Marei W, Fouladi Nashta A, El Saba A. Histochemical structure and immunolocalisation of the hyaluronan system in the dromedary oviduct. Reprod Fertil Dev. 2016;28:936-947 pubmed publisher
    ..focusing on the immnolocalisation of hyaluronic acid (HA) synthases (HAS2 and HAS3), hyaluronidases (HYAL2 and HYAL1) and the HA receptor CD44 in the ampulla and isthmus...
  52. Della Colleta H, Carvalho H. Hyaluronan Content and Distribution in the Rat Ventral Prostate after Castration. Biochem Cell Biol. 2018;: pubmed publisher
    ..Hyaluronan synthases (HAS 1-3) and hyaluronidases (Hyal 1-3) mRNA abundance and CD44 (a HA receptor) distribution were assessed by RT-PCR and immunohistochemistry, ..
  53. Kiykim E, Barut K, Cansever M, Zeybek C, Zubarioglu T, Aydin A, et al. Screening Mucopolysaccharidosis Type IX in Patients with Juvenile Idiopathic Arthritis. JIMD Rep. 2016;25:21-24 pubmed
    ..187). In conclusion, the data reported in our study indicates that systemic metabolic investigation for hyaluronidase activity is not recommended in all patients with JIA. ..
  54. Beghini J, Giraldo P, Eleutério J, Amaral R, Polpeta N, Gonçalves A. Vaginal Inflammation: Association between Leukocyte Concentration and Levels of Immune Mediators. Am J Reprod Immunol. 2016;75:126-33 pubmed publisher
    ..05), while Hyal-1 did not. EMMPRIN concentrations were correlated with HA and MMP-8 levels. EMMPRIN, MMP-8, HA, β-defensin, and NGAL are elevated in women with vaginal inflammation. ..
  55. Triggs Raine B, Salo T, Zhang H, Wicklow B, Natowicz M. Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. Proc Natl Acad Sci U S A. 1999;96:6296-300 pubmed
    ..3 and encoding proteins with homology to a sperm protein with hyaluronidase activity. These genes, HYAL1 and HYAL2, encode two distinct lysosomal hyaluronidases with different substrate specificities...
  56. Shuttleworth T, Wilson M, Wicklow B, Wilkins J, Triggs Raine B. Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. J Biol Chem. 2002;277:23008-18 pubmed
    ..have been identified, but the only clue to the function of their products has come from the identification of hyaluronidase 1 deficiency in a single patient with a mild clinical phenotype...
  57. Monzon M, Manzanares D, Schmid N, Casalino Matsuda S, Forteza R. Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells. Am J Respir Cell Mol Biol. 2008;39:289-95 pubmed publisher
    ..Our observations indicate that Hyal 1, 2, and 3 are expressed in airway epithelium and may operate in a coordinated fashion to depolymerize HA during ..
  58. Anedchenko E, Dmitriev A, Krasnov G, Kondrat eva T, Kopantsev E, Vinogradova T, et al. [Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer]. Mol Biol (Mosk). 2008;42:965-76 pubmed
    ..3 (RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 in basic types of non-small cell lung cancer (NSCLC)--squamous cell lung cancer (SCC) and lung ..
  59. Reitinger S, Müllegger J, Greiderer B, Nielsen J, Lepperdinger G. Designed human serum hyaluronidase 1 variant, HYAL1DeltaL, exhibits activity up to pH 5.9. J Biol Chem. 2009;284:19173-7 pubmed publisher
    ..Human serum hyaluronidase 1 (HYAL1) is active solely below pH 5.1...
  60. Monzon M, Fregien N, Schmid N, Falcon N, Campos M, Casalino Matsuda S, et al. Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation. J Biol Chem. 2010;285:26126-34 pubmed publisher
    ..In summary, this work provides evidence that ROS induce Hyal2, suggesting that Hyal2 is likely responsible for the sustained HA fragmentation in the airway lumen observed in inflammatory conditions associated with oxidative stress. ..
  61. Lanktree M, Johansen C, Anand S, Davis A, Miller R, Yusuf S, et al. Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration. Blood. 2010;116:2160-3 pubmed publisher
    ..05). However, 5 loci (HABP2, HSPA1A, HYAL1, MBTPS1, TARP) were associated with PAI-1 concentration at a P < 1 × 10(-5) threshold...
  62. Yoffou P, Edjekouane L, Meunier L, Tremblay A, Provencher D, Mes Masson A, et al. Subtype specific elevated expression of hyaluronidase-1 (HYAL-1) in epithelial ovarian cancer. PLoS ONE. 2011;6:e20705 pubmed publisher
    ..Our objective was to evaluate the expression of HYAL1, located at chromosome 3p21...
  63. Gurski L, Xu X, Labrada L, Nguyen N, Xiao L, van Golen K, et al. Hyaluronan (HA) interacting proteins RHAMM and hyaluronidase impact prostate cancer cell behavior and invadopodia formation in 3D HA-based hydrogels. PLoS ONE. 2012;7:e50075 pubmed publisher
    ..Thus, we report development of a 3D system amenable to dissection of biological processes associated with cancer cell motility through HA-rich connective tissues...
  64. Nykopp T, Pasonen Seppänen S, Tammi M, Tammi R, Kosma V, Anttila M, et al. Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer. Gynecol Oncol. 2015;137:152-9 pubmed publisher
    Hyaluronidases (HYAL1 and HYAL2) are key enzymes in the degradation of hyaluronan, and their expression has been altered in various cancer types...
  65. Panogeorgou T, Tserbini E, Filou S, Vynios D, Naxakis S, Papadas T, et al. Hyaluronan synthases and hyaluronidases in nasal polyps. Eur Arch Otorhinolaryngol. 2016;273:1801-8 pubmed publisher
    ..Therefore, they could be a potential target for the design of a more advanced treatment for nasal polyposis. ..
  66. Wei M, Latif F, Bader S, Kashuba V, Chen J, Duh F, et al. Construction of a 600-kilobase cosmid clone contig and generation of a transcriptional map surrounding the lung cancer tumor suppressor gene (TSG) locus on human chromosome 3p21.3: progress toward the isolation of a lung cancer TSG. Cancer Res. 1996;56:1487-92 pubmed
    ..This large cosmid clone contig and high resolution maps will prove crucial in the identification of the lung cancer TSG(s). ..
  67. Csoka A, Frost G, Heng H, Scherer S, Mohapatra G, Stern R, et al. The hyaluronidase gene HYAL1 maps to chromosome 3p21.2-p21.3 in human and 9F1-F2 in mouse, a conserved candidate tumor suppressor locus. Genomics. 1998;48:63-70 pubmed
    We recently cloned and expressed the major hyaluronidase activity from human plasma, HYAL1, and found that the protein is 40% identical to the testicular hyaluronidase, PH-20...
  68. Chow G, Knudson C, Knudson W. Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines. Osteoarthritis Cartilage. 2006;14:849-58 pubmed
    ..Thus, local turnover of HA is dependent on receptor-mediated endocytosis and delivery to low pH intracellular organelles for its complete degradation. ..
  69. Kramer M, Escudero D, Lokeshwar S, Golshani R, Ekwenna O, Acosta K, et al. Association of hyaluronic acid family members (HAS1, HAS2, and HYAL-1) with bladder cancer diagnosis and prognosis. Cancer. 2011;117:1197-209 pubmed publisher
    ..004; RR = 6.7). HYAL-1 and HAS1 expression predicted BCa metastasis, and HYAL-1 expression also predicted disease-specific survival. Furthermore, the combined HAS2-HYAL-1 biomarker detected BCa and significantly predicted its recurrence. ..
  70. Tan J, Wang X, Su X, Li H, Shi Y, Wang L, et al. Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis. PLoS ONE. 2011;6:e22836 pubmed publisher
    ..Hyaluronidase-1 (HYAL1) is the major tumor-derived HAase...
  71. Goto Y, Niwa Y, Suzuki T, Dohmae N, Umezawa K, Simizu S. C-mannosylation of human hyaluronidase 1: possible roles for secretion and enzymatic activity. Int J Oncol. 2014;45:344-50 pubmed publisher
    ..b>Hyaluronidase 1 (HYAL1), degrading hyaluronic acid (HA), has two predicted C-mannosylation sites at Trp¹³? and Trp³²¹...
  72. Ni Y, Zhao S, Yin X, Wang H, Guang Q, Hu G, et al. Intravesicular administration of sodium hyaluronate ameliorates the inflammation and cell proliferation of cystitis cystica et glandularis involving interleukin-6/JAK2/Stat3 signaling pathway. Sci Rep. 2017;7:15892 pubmed publisher
    ..Immunohistochemical staining showed that the staining intensities of hyaluronidase (HYAL 1/2), CD44, IL-6 and phosphorylated signal transducer and activator of transcription 3 (p-Stat3) in bladder mucosal ..
  73. Natowicz M, Short M, Wang Y, Dickersin G, Gebhardt M, Rosenthal D, et al. Clinical and biochemical manifestations of hyaluronidase deficiency. N Engl J Med. 1996;335:1029-33 pubmed
  74. Lokeshwar V, Schroeder G, Carey R, Soloway M, Iida N. Regulation of hyaluronidase activity by alternative mRNA splicing. J Biol Chem. 2002;277:33654-63 pubmed
    ..Increased concentration of HYAL1-type hyaluronidase correlates with tumor progression and is a marker for grade (G) 2 or 3 bladder cancer...
  75. Selbi W, de La Motte C, Hascall V, Day A, Bowen T, Phillips A. Characterization of hyaluronan cable structure and function in renal proximal tubular epithelial cells. Kidney Int. 2006;70:1287-95 pubmed
    ..In addition, hyaluronidase (hyal1 and hyal2) and bikunin mRNA expression were increased, whereas PalphaI HC3 mRNA expression was unchanged in the ..
  76. Lokeshwar V, Estrella V, Lopez L, Kramer M, Gomez P, Soloway M, et al. HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. Cancer Res. 2006;66:11219-27 pubmed
    Tumor cells express HYAL1 hyaluronidase, which degrades hyaluronic acid. HYAL1 expression in bladder cancer cells promotes tumor growth, invasion, and angiogenesis...
  77. Li L, Asteriou T, Bernert B, Heldin C, Heldin P. Growth factor regulation of hyaluronan synthesis and degradation in human dermal fibroblasts: importance of hyaluronan for the mitogenic response of PDGF-BB. Biochem J. 2007;404:327-36 pubmed
    ..that PDGF-BB treatment induced a 3-fold increase in the already high level of HAS2 mRNA, and increases in HAS1 and HYAL1 mRNA, whereas the levels of HAS3 and HYAL2 mRNA were not affected...
  78. Bharadwaj A, Rector K, Simpson M. Inducible hyaluronan production reveals differential effects on prostate tumor cell growth and tumor angiogenesis. J Biol Chem. 2007;282:20561-72 pubmed
    ..can be predicted in human tumor biopsies by abundant hyaluronan (HA) and its processing enzyme, the hyaluronidase HYAL1. Accumulation of HA is dictated by the balance between expression levels of HA synthases, the enzymes that produce ..
  79. Zhang L, Bharadwaj A, Casper A, Barkley J, Barycki J, Simpson M. Hyaluronidase activity of human Hyal1 requires active site acidic and tyrosine residues. J Biol Chem. 2009;284:9433-42 pubmed publisher
    ..However, elevated expression of the Hyal1 isozyme accelerates tumor growth and metastatic progression...
  80. Gasingirwa M, Thirion J, Mertens Strijthagen J, Wattiaux de Coninck S, Flamion B, Wattiaux R, et al. Endocytosis of hyaluronidase-1 by the liver. Biochem J. 2010;430:305-13 pubmed publisher
    ..Although its degradation half-time is short, Hyal-1 could exert its activity due to a constant supply of active molecules from the blood. ..
  81. Bouga H, Tsouros I, Bounias D, Kyriakopoulou D, Stavropoulos M, Papageorgakopoulou N, et al. Involvement of hyaluronidases in colorectal cancer. BMC Cancer. 2010;10:499 pubmed publisher
    ..The results provided new evidence on the mechanisms involved in the progression of colorectal cancer. ..
  82. Kurdykowski S, Mine S, Bardey V, Danoux L, Jeanmaire C, Pauly G, et al. Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes. Photochem Photobiol. 2011;87:1105-12 pubmed publisher
    ..The mRNA expression of HYAL1, HYAL2 and HYAL3 and the hyaluronidase enzymatic activity were quantified using real-time PCR and a microtiter-..
  83. Eissa S, Matboli M, Essawy N, Kotb Y. Integrative functional genetic-epigenetic approach for selecting genes as urine biomarkers for bladder cancer diagnosis. Tumour Biol. 2015;36:9545-52 pubmed publisher
    ..1) We analyzed the expression of urinary Hyaluronoglucosaminidase 1 (HYAL1) protein in BC and control samples by zymography...
  84. Meshach Paul D, Rajasekaran R. In silico approach to explore the disruption in the molecular mechanism of human hyaluronidase 1 by mutant E268K that directs Natowicz syndrome. Eur Biophys J. 2017;46:157-169 pubmed publisher
    ..mucopolysaccharidoses type 9) is a lysosomal storage disorder caused by deficient or defective human hyaluronidase 1. The disorder is not well studied at the molecular level...
  85. Witzel I, Marx A, Muller V, Wikman H, Matschke J, Schumacher U, et al. Role of HYAL1 expression in primary breast cancer in the formation of brain metastases. Breast Cancer Res Treat. 2017;162:427-438 pubmed publisher
    ..hypothesized that two enzymes involved in the hyaluronan metabolism, namely, hyaluronan synthase 2 (HAS2) and hyaluronidase 1 (HYAL1) are associated with brain metastases formation...
  86. Compagnone M, Gatti V, Presutti D, Ruberti G, Fierro C, Markert E, et al. ?Np63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis. Proc Natl Acad Sci U S A. 2017;114:13254-13259 pubmed publisher
    ..Altogether, our data shed light on a ?Np63-dependent pathway functionally important to the regulation of HNSCC progression. ..
  87. Hofinger E, Spickenreither M, Oschmann J, Bernhardt G, Rudolph R, Buschauer A. Recombinant human hyaluronidase Hyal-1: insect cells versus Escherichia coli as expression system and identification of low molecular weight inhibitors. Glycobiology. 2007;17:444-53 pubmed
    ..Within this series, l-ascorbic acid tridecanoate was identified as the most potent inhibitor with an IC(50) of 50 +/- 4 microM comparable with glycyrrhizic acid. ..
  88. Chao K, Muthukumar L, Herzberg O. Structure of human hyaluronidase-1, a hyaluronan hydrolyzing enzyme involved in tumor growth and angiogenesis. Biochemistry. 2007;46:6911-20 pubmed
    ..Thus, these variants may function by competing with the full-length enzyme for the putative protein partner and regulating enzymatic activity in healthy cells. ..
  89. Poola I, Abraham J, Marshalleck J, Yue Q, Lokeshwar V, Bonney G, et al. Molecular risk assessment for breast cancer development in patients with ductal hyperplasias. Clin Cancer Res. 2008;14:1274-80 pubmed publisher
    ..The purpose of this study is to investigate whether expression of hyaluronoglucosaminidase 1 (HYAL1), a known tumor promoter, in hyperplastic tissues identifies a "true precancerous stage" and predicts ..
  90. Lenormand H, Deschrevel B, Tranchepain F, Vincent J. Electrostatic interactions between hyaluronan and proteins at pH 4: how do they modulate hyaluronidase activity. Biopolymers. 2008;89:1088-103 pubmed publisher
    ..These results, in addition to data in the literature, show that HA-protein complexes, which can exist under numerous and varied conditions of pH, ionic strength and protein over HA ratio, might control the in vivo HAase activity. ..
  91. Imundo L, LeDuc C, Guha S, Brown M, Perino G, Gushulak L, et al. A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis. J Inherit Metab Dis. 2011;34:1013-22 pubmed publisher
    ..Dideoxy sequencing identified a homozygous deletion in HYAL1, c.104delT, resulting in a premature termination codon, p.Val35AlafsX25, found in all three affected children...
  92. Ma X, Gao X. The effect of Ureaplasma urealyticum on the level of P34H expression, the activity of hyaluronidase, and DNA fragmentation in human spermatozoa. Am J Reprod Immunol. 2017;77: pubmed publisher
    ..Ureaplasma urealyticum infection may affect the level of P34H protein expression, the percentage of the P34H-positive rate, the activity of HYD, and DNA fragmentation that influence fertility. ..