HuR

Summary

Gene Symbol: HuR
Description: ELAV like RNA binding protein 1
Alias: ELAV1, HUR, Hua, MelG, ELAV-like protein 1, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R), Hu antigen R, embryonic lethal, abnormal vision, drosophila, homolog-like 1, hu-antigen R
Species: human

Top Publications

  1. ncbi IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR
    Esther A Suswam
    Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA
    Int J Cancer 113:911-9. 2005
  2. pmc Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46459. 2012
  3. pmc The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells
    Wan Lin Liao
    Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    J Biol Chem 286:35499-508. 2011
  4. pmc Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation
    Yuki Kuwano
    RNA Regulation Section, Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Mol Cell Biol 29:2622-35. 2009
  5. pmc T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade
    Vinod S Ramgolam
    Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine Cardiovascular Medicine and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e14450. 2010
  6. pmc Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
    Kylie Warren
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, QLD, Australia E Mails K W D W L M
    Viruses 1:873-94. 2009
  7. pmc Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells
    Selvi C Jeyaraj
    Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210, USA
    Am J Physiol Renal Physiol 291:F1255-63. 2006
  8. doi HuR regulates beta-tubulin isotype expression in ovarian cancer
    Giuseppina Raspaglio
    Laboratory of Antineoplastic Pharmacology, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy
    Cancer Res 70:5891-900. 2010
  9. ncbi Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis
    Eiji Suzuki
    Department of Clinical Immunology, University of Tsukuba, Ibaraki 305 8575, Japan
    Int J Mol Med 18:273-8. 2006
  10. pmc Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis
    Rachid Mazroui
    Department of Biochemistry, McGill University Health Center, McGill University, Montreal, Quebec H3G 146, Canada
    J Cell Biol 180:113-27. 2008

Research Grants

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
  2. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
  3. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
  4. Peter H King; Fiscal Year: 2015
  5. RNA Binding Proteins in Cancer
    Shrikant Anant; Fiscal Year: 2013
  6. Post-Transcriptional Regulation in Colorectal Cancer
    DAN ALAN DIXON; Fiscal Year: 2013
  7. Posttranscriptional Gene Regulation in Asthma
    Ulus Atasoy; Fiscal Year: 2010
  8. Jack D Keene; Fiscal Year: 2015
  9. FAOUD TERRENCE ISHMAEL; Fiscal Year: 2014
  10. VISWANATHAN PALANISAMY; Fiscal Year: 2016

Detail Information

Publications226 found, 100 shown here

  1. ncbi IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR
    Esther A Suswam
    Birmingham Veterans Affairs Medical Center, Birmingham, AL, USA
    Int J Cancer 113:911-9. 2005
    ..Immunoprecipitation analysis indicated that HuR, KSRP and TIAR bound to one or more loci in the 3'UTR...
  2. pmc Angiogenesis inhibitor vasohibin-1 enhances stress resistance of endothelial cells via induction of SOD2 and SIRT1
    Hiroki Miyashita
    Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    PLoS ONE 7:e46459. 2012
    ..The synthesis of VASH1 was regulated by HuR-mediated post-transcriptional regulation. We sought to define the underlying mechanism...
  3. pmc The RNA-binding protein HuR stabilizes cytosolic phospholipase A2α mRNA under interleukin-1β treatment in non-small cell lung cancer A549 Cells
    Wan Lin Liao
    Institute of Bioinformatics and Biosignal Transduction, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan 701, Taiwan
    J Biol Chem 286:35499-508. 2011
    ..By using EMSAs, HuR was identified as binding with the cPLA(2)α mRNA 3'-UTR, and the binding region was located at nucleotides 2716-..
  4. pmc Analysis of nitric oxide-stabilized mRNAs in human fibroblasts reveals HuR-dependent heme oxygenase 1 upregulation
    Yuki Kuwano
    RNA Regulation Section, Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Mol Cell Biol 29:2622-35. 2009
    ..All seven mRNAs showed at least one hit of a signature motif for the stabilizing RNA-binding protein (RBP) HuR; accordingly, ribonucleoprotein immunoprecipitation analysis revealed that all seven mRNAs associated with HuR...
  5. pmc T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 signaling cascade
    Vinod S Ramgolam
    Raymond and Beverly Sackler Foundation Cardiovascular Laboratory, Departments of Medicine Cardiovascular Medicine and Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 5:e14450. 2010
    ..AU-rich elements (AREs) by inducing rapid nuclear-to-cytosolic translocation of the RNA-stabilizing protein, HuR. However, little is known regarding integrin-induced signaling cascades that affect mRNA catabolism...
  6. pmc Reverse Transcriptase and Cellular Factors: Regulators of HIV-1 Reverse Transcription
    Kylie Warren
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, QLD, Australia E Mails K W D W L M
    Viruses 1:873-94. 2009
    ..In addition, recent studies implicate the cellular proteins HuR, AKAP149, and DNA topoisomerase I in reverse transcription through an interaction with RT...
  7. pmc Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells
    Selvi C Jeyaraj
    Department of Physiology and Cell Biology, The Ohio State University, 1645 Neil Ave, Columbus, OH 43210, USA
    Am J Physiol Renal Physiol 291:F1255-63. 2006
    Human antigen R (HuR) is a nucleocytoplasmic shuttling protein that binds to and stabilizes mRNAs containing adenine- and uridine-rich elements...
  8. doi HuR regulates beta-tubulin isotype expression in ovarian cancer
    Giuseppina Raspaglio
    Laboratory of Antineoplastic Pharmacology, Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy
    Cancer Res 70:5891-900. 2010
    ..In silico analysis of TUBB3 mRNA sequence predicted a putative binding site for the RNA-binding protein Hu antigen (HuR) in the 3' flanking untranslated region...
  9. ncbi Expression of TNF-alpha, tristetraprolin, T-cell intracellular antigen-1 and Hu antigen R genes in synovium of patients with rheumatoid arthritis
    Eiji Suzuki
    Department of Clinical Immunology, University of Tsukuba, Ibaraki 305 8575, Japan
    Int J Mol Med 18:273-8. 2006
    ..We measured the gene expression of ARBPs, including tristetraprolin, T-cell intracellular antigen (TIA)-1 and Hu antigen R (HuR), in synovial tissues from RA and osteoarthritis patients...
  10. pmc Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis
    Rachid Mazroui
    Department of Biochemistry, McGill University Health Center, McGill University, Montreal, Quebec H3G 146, Canada
    J Cell Biol 180:113-27. 2008
    The RNA-binding protein HuR affects cell fate by regulating the stability and/or the translation of messenger RNAs that encode cell stress response proteins...
  11. ncbi Control of the ATP synthase beta subunit expression by RNA-binding proteins TIA-1, TIAR, and HuR
    José M Izquierdo
    Centro de Biologia Molecular Severo Ochoa, Universidad Autónoma de Madrid UAM CSIC, Facultad de Ciencias, Módulo C V, Lab 230, Cantoblanco, DP 28049, Madrid, Spain
    Biochem Biophys Res Commun 348:703-11. 2006
    ..element-binding proteins TIA-1 (T-cell intracellular antigen-1), TIAR (TIA-1-related protein), and HuR (Hu antigen R) interact with the beta-F1-ATPase mRNA through an AU-rich sequence located to the 3'-UTR...
  12. ncbi Post-transcriptional control of the MCT-1-associated protein DENR/DRP by RNA-binding protein AUF1
    Krystyna Mazan-Mamczarz
    University of Maryland, Marlene and Stewart Greenebaum Cancer Center 9 011 BRB, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    Cancer Genomics Proteomics 4:233-9. 2007
    ..RBPs binding to AREs such as AUF1, BRF1, KSRP, and TTP are known to regulate mRNA turnover, while TIAR and TIA-1 influence mRNA translation...
  13. ncbi Post-transcriptional regulation of HSP70 expression following oxidative stress in SH-SY5Y cells: the potential involvement of the RNA-binding protein HuR
    M Amadio
    Experimental and Applied Pharmacology Department, University of Pavia, Pavia, Italy
    Curr Pharm Des 14:2651-8. 2008
    ..In the present report we show that the RNA-binding protein ELAV/HuR can affect, post-transcriptionally, the fate of HSP70 mRNA following H(2)O(2)-mediated oxidative stress in SH-SY5Y ..
  14. pmc HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis
    Mercedes Vazquez-Chantada
    Centro de Investigación Cooperativa en Biociencias CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Technology Park of Bizkaia, Bizkaia, Spain
    Gastroenterology 138:1943-53. 2010
    ..MAT1A is expressed in the adult liver, whereas MAT2A expression primarily is extrahepatic and is associated strongly with liver proliferation. The mechanisms that regulate these expression patterns are not completely understood...
  15. pmc Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock
    I E Gallouzi
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    RNA 7:1348-61. 2001
    ..b>HuR, an RRM-containing RNA-binding protein, specifically interacts with AREs, stabilizing these mRNAs...
  16. ncbi Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase
    Hongwei Li
    Department of Pathology, University of Southern California, Keck School of Medicine, Los Angeles, California 90089 9176, USA
    J Biol Chem 277:44623-30. 2002
    The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements. This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light...
  17. pmc The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation
    Zheng Meng
    Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham Birmingham, AL 35294, USA
    Nucleic Acids Res 33:2962-79. 2005
    ..Here, we report the purification and identification of one of these IGF-IR 5'-UTR-binding proteins as HuR, using a novel RNA crosslinking/RNase elution strategy...
  18. doi p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR
    Faraz Farooq
    University of Ottawa, Ottawa K1H 8M5, Canada
    Hum Mol Genet 18:4035-45. 2009
    ..We demonstrate that Anisomycin activation of p38 causes a rapid cytoplasmic accumulation of HuR, a RNA binding protein which binds to and stabilizes the AU-rich element within the SMN transcript...
  19. ncbi HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities
    K Spångberg
    Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, 751 23, Sweden
    Virology 274:378-90. 2000
    ..Two of these proteins were identified as the ELAV-like HuR protein and hnRNP C...
  20. pmc AMP-activated kinase regulates cytoplasmic HuR
    Wengong Wang
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Internal Research Program, National Institutes of Health, Baltimore, Mayland 21224 6825, USA
    Mol Cell Biol 22:3425-36. 2002
    While transport of RNA-binding protein HuR from nucleus to cytoplasm is emerging as a key regulatory step for HuR function, the mechanisms underlying this process remain poorly understood...
  21. ncbi Role of the RNA-binding protein HuR in colon carcinogenesis
    Isabel Lopez de Silanes
    Laboratory of Cellular and Molecular Biology, National Institute of Health, Baltimore, MD 21224, USA
    Oncogene 22:7146-54. 2003
    ..tumor and normal tissue specimens revealed that the expression and cytoplasmic abundance of the RNA-binding protein HuR increased with malignancy, particularly in colon carcinomas...
  22. pmc Transportin2 functions as importin and mediates nuclear import of HuR
    Stephan Güttinger
    Swiss Federal Institute of Technology, Institute of Biochemistry, HPM F11 1, 8093 Zurich, Switzerland
    Proc Natl Acad Sci U S A 101:2918-23. 2004
    ..As expected of an import complex, RanGTP also disrupted the interaction between TRN2 and HuR, an RNA-binding protein previously described as a TRN2 export substrate...
  23. pmc Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR
    Ana Rebane
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    RNA 10:590-9. 2004
    Several mRNA-binding proteins, including hnRNP A1 and HuR, contain bidirectional transport signals that mediate both their nuclear import and export...
  24. ncbi Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    Carsten Denkert
    Institute of Pathology, Charite Hospital, Berlin, Germany
    Clin Cancer Res 10:5580-6. 2004
    The human ELAV (embryonic lethal abnormal vision)-like protein HuR stabilizes a certain group of cellular mRNAs that contain AU-rich elements in their 3'-untranslated region...
  25. pmc Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR
    Tomoko Kawai
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program NIH, Box 12, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    Mol Cell Biol 26:3295-307. 2006
    ..proteins that associate with its approximately 900-bp-long, adenine- and uridine-rich 3' untranslated region (UTR): HuR, which displayed affinity for several regions of the cytochrome c 3'UTR, and T-cell-restricted intracellular ..
  26. ncbi HuR: post-transcriptional paths to malignancy
    Isabel Lopez de Silanes
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland, USA
    RNA Biol 2:11-3. 2005
    The RNA-binding protein HuR regulates the stability and translation of target mRNAs...
  27. ncbi Posttranscriptional orchestration of an anti-apoptotic program by HuR
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, Maryland 21224, USA
    Cell Cycle 6:1288-92. 2007
    The RNA-binding protein HuR can stabilize and/or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents...
  28. pmc FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1
    Pamela S David
    Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA
    RNA 13:1453-68. 2007
    ..Two ARE binding proteins, HuR and AUF1, are associated with mRNA stabilization and destabilization, respectively...
  29. pmc Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR
    Vincenzo Casolaro
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Allergy Clin Immunol 121:853-9.e4. 2008
    ..IL-13, a critical cytokine in allergy, is regulated by as-yet-elusive mechanisms...
  30. doi Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human meningiomas
    Takahiro Sakuma
    Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Yoshida gun, Fukui 910 1193, Japan
    J Neurooncol 88:143-55. 2008
    We studied the expression of vascular endothelial growth factor-A (VEGF-A) and mRNA stability factor HuR in 40 supratentorial meningiomas using RT-PCR, ELISA and immunohistochemistry, and analyzed their associations with the ..
  31. doi Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition
    José M Izquierdo
    Departamento de Biología Molecular and the Centro de Biología Molecular Severo Ochoa, C S I C, Universidad Autonoma de Madrid, Cantoblanco 28049, Madrid, Spain
    J Biol Chem 283:19077-84. 2008
    ..I report that antiapoptotic regulator Hu antigen R (HuR, ELAVL1), a member of the embryonic lethal, abnormal vision, Drosophila-like (ELAVL) family, promotes Fas ..
  32. doi Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR
    Jodi M Saunus
    School of Molecular and Microbial Sciences, The University of Queensland and The Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
    Cancer Res 68:9469-78. 2008
    ..BRCA1 is posttranscriptionally regulated by RNA-binding proteins, the identities of which are unknown. HuR is an RNA binding protein implicated in posttranscriptional regulation of many genes and is overexpressed in ..
  33. pmc RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth
    W Al-Ahmadi
    Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Oncogene 28:1782-91. 2009
    ..Here, we show that overexpression of RNase L decreases cellular growth and downmodulates the RNA-binding protein, HuR, a regulator of cell-cycle progression and tumorigenesis...
  34. doi Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins
    Debashish Ray
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 27:667-70. 2009
    ..We tested RNAcompete by analyzing nine diverse RBPs (HuR, Vts1, FUSIP1, PTB, U1A, SF2/ASF, SLM2, RBM4 and YB1)...
  35. pmc Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR)
    Christopher von Roretz
    Biochemistry Department and Rosalind and Morris Goodman Cancer Center, McGill University, Montreal, Ontario H3G 1Y6, Canada
    J Biol Chem 285:16806-13. 2010
    The RNA-binding protein human antigen R (HuR) has been implicated in apoptosis in multiple ways...
  36. pmc The RNA-binding protein HuR promotes glioma growth and treatment resistance
    Natalia Filippova
    Department of Neurology, Division of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Mol Cancer Res 9:648-59. 2011
    ..We previously found that the mRNA-binding protein, ELAV 1 (HuR), is upregulated in primary brain tumors and stabilizes growth factor mRNAs such as VEGF and IL-8...
  37. doi Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR
    Svetlana Lebedeva
    Laboratory of Systems Biology of Gene Regulatory Elements, Max Delbruck Center for Molecular Medicine, Berlin, Germany
    Mol Cell 43:340-52. 2011
    ..The human RBP HuR/ELAVL1 is a conserved mRNA stability regulator...
  38. pmc HuR regulates alternative splicing of the TRA2β gene in human colon cancer cells under oxidative stress
    Yoko Akaike
    Department of Stress Science, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan
    Mol Cell Biol 34:2857-73. 2014
    b>Hu antigen R (HuR) regulates stress responses through stabilizing and/or facilitating the translation of target mRNAs...
  39. ncbi Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
    W J Ma
    Program in Molecular Pharmacology and Therapeutics, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Biol Chem 271:8144-51. 1996
    ..We have identified and cloned a fourth member of this family (HuR) that is expressed in a wide variety of cell types...
  40. pmc HuR regulates p21 mRNA stabilization by UV light
    W Wang
    Laboratory of Biological Chemistry, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell Biol 20:760-9. 2000
    ..The ubiquitous Elav-type RNA-binding protein HuR was identified within the p21 mRNA-protein complexes, as antibodies recognizing HuR supershifted these complexes ..
  41. pmc Protein ligands to HuR modulate its interaction with target mRNAs in vivo
    C M Brennan
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536, USA
    J Cell Biol 151:1-14. 2000
    ..b>HuR, a ubiquitously expressed member of the ELAV (embryonic lethal abnormal vision) family of RNA binding proteins, ..
  42. ncbi Delineation of mRNA export pathways by the use of cell-permeable peptides
    I E Gallouzi
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 294:1895-901. 2001
    ..We show that HuR, a protein implicated in the stabilization of short-lived mRNAs containing AU-rich elements (AREs), serves as an ..
  43. pmc Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization
    Chyi Ying A Chen
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston, Texas 77030, USA
    Mol Cell Biol 22:7268-78. 2002
    Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously expressed member of the family of Hu proteins, which consist of two N-terminal RNA recognition motifs (RRM1 and RRM2), a hinge region, and a C-..
  44. ncbi Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function
    Wengong Wang
    Laboratory of Cellular and Molecular Biology, NIA Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 278:27016-23. 2003
    Cytoplasmic export of the RNA-binding protein HuR, a process that critically regulates its function, was recently shown to be inhibited by the AMP-activated protein kinase (AMPK)...
  45. pmc RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
    Krystyna Mazan-Mamczarz
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 100:8354-9. 2003
    ..The 3' UTR of p53 was found to be a target of the RNA-binding protein HuR in a UVC-dependent manner in vitro and in vivo...
  46. ncbi The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U
    Steven J Cok
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:36157-62. 2003
    ..We identified four members of the protein-RNA complex as HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U (hnRNP U)...
  47. pmc Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2
    Hoanh Tran
    Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, CH 4058 Basel, Switzerland
    Mol Cell Biol 23:7177-88. 2003
    ..We show here that the mRNA-stabilizing factor HuR functionally interacts with these sequences...
  48. ncbi Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR
    Ulus Atasoy
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 171:4369-78. 2003
    ..Evidence that the mRNA-stabilizing protein HuR participated in the cytokine effect was obtained: first, HuR presence in the cytoplasm, believed to be required for ..
  49. pmc Identification of a target RNA motif for RNA-binding protein HuR
    Isabel Lopez de Silanes
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 101:2987-92. 2004
    b>HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal posttranscriptional regulator of gene expression...
  50. pmc Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs
    Ashish Lal
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, Baltimore, MD 21224, USA
    EMBO J 23:3092-102. 2004
    RNA-binding proteins HuR and AUF1 bind to many common AU-rich target mRNAs and exert opposing influence on target mRNA stability, but the functional interactions between HuR and AUF1 have not been systematically studied...
  51. ncbi AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR
    Wengong Wang
    Laboratory of Cellular and Molecular Biology, NIA Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 279:48376-88. 2004
    Nuclear import of HuR, a shuttling RNA-binding protein, is associated with reduced stability of its target mRNAs...
  52. pmc Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR
    Rudolf Pullmann
    Laboratory of Cellular and Molecular Biology and Laboratory of Cardiovascular Sciences, NIA Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    J Biol Chem 280:22819-26. 2005
    In dividing cells, the RNA-binding protein HuR associates with and stabilizes labile mRNAs encoding proliferative proteins, events that are linked to the increased cytoplasmic presence of HuR...
  53. pmc Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha
    Ashish Lal
    Laboratory of Cellular and Molecular Biology, National Institute on Aging IRP, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    EMBO J 24:1852-62. 2005
    We report the antiapoptotic effect of RNA-binding protein HuR, a critical regulator of the post-transcriptional fate of target transcripts...
  54. pmc RNA-binding protein HuR is required for stabilization of SLC11A1 mRNA and SLC11A1 protein expression
    Yong Zhong Xu
    McGill University, Departments of Experimental Medicine and Human Genetics, 1650 Cedar Avenue, L11 218, Montreal, QC, Canada H3G 1A4
    Mol Cell Biol 25:8139-49. 2005
    ..in human monocytes and HL-60 cells and then use HL-60 cells as a model to determine whether RNA-binding protein HuR is associated with the ARE and involved in SLC11A1 mRNA turnover...
  55. ncbi LFA-1-dependent HuR nuclear export and cytokine mRNA stabilization in T cell activation
    Jin Gene Wang
    Sections of Cardiovascular Medicine and Immunobiology, Vascular Biology and Transplant Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    J Immunol 176:2105-13. 2006
    ..T cell stimulation by LFA-1 promotes rapid nuclear-to-cytoplasmic translocation of the mRNA-stabilizing protein HuR, which in turn is capable of binding an AU-rich element sequence in vitro...
  56. ncbi IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression
    Johnson Rajasingh
    Division of Cardiovascular Research, Caritas St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, Massachusetts 02135, USA
    FASEB J 20:2112-4. 2006
    ..IL-10 sensitivity to TNF depends on the ability of IL-10 to inhibit the expression and mRNA-stabilizing protein HuR and via IL-10 mediated repression of p38 mitogen-activated protein (MAP) kinase activation...
  57. ncbi Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression
    Barbara Fries
    Heinrich Pette Institute for Experimental Virology and Immunology, Martinistrasse 52, 20251 Hamburg, Germany
    J Biol Chem 282:4504-15. 2007
    ..It has been recently shown that CD83 mRNA is transported from the nucleus to the cytoplasm in a HuR- and CRM1-dependent manner...
  58. pmc Phosphorylation of HuR by Chk2 regulates SIRT1 expression
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Mol Cell 25:543-57. 2007
    The RNA binding protein HuR regulates the stability of many target mRNAs...
  59. ncbi Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation
    Sripathi M Sureban
    Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, USA
    Gastroenterology 132:1055-65. 2007
    ..Although structurally homologous RNA binding proteins HuR and CUGBP2 stabilize COX-2 mRNA, HuR induces whereas CUGBP2 inhibits COX-2 mRNA translation...
  60. pmc Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences
    Elizabeth J Fialcowitz-White
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 282:20948-59. 2007
    The RNA-binding factor HuR is a ubiquitously expressed member of the Hu protein family that binds and stabilizes mRNAs containing AU-rich elements (AREs)...
  61. pmc The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner
    Virginie Dormoy-Raclet
    Department of Biochemistry, and McGill Cancer Center, McGill University, McIntyre Building, Room 904, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6
    Mol Cell Biol 27:5365-80. 2007
    ..Here we show that the RNA-binding protein HuR stabilizes the beta-actin mRNA by associating with a uridine-rich element within its 3' untranslated region...
  62. ncbi Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
    Nicole Claudia Meisner
    Novartis Institutes for BioMedical Research, Discovery Technologies, Brunnerstr 59, A 1235 Vienna, Austria
    Nat Chem Biol 3:508-15. 2007
    ..the identification and mechanistic characterization of the first low-molecular-weight inhibitors for Hu protein R (HuR) from microbial broths (Actinomyces sp.): dehydromutactin (1), MS-444 (2) and okicenone (3)...
  63. pmc RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha
    Stefanie Galban
    LCMB, NIA, NIH, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Mol Cell Biol 28:93-107. 2008
    ..Instead, we postulated that RNA-binding proteins HuR and PTB, previously shown to bind HIF-1alpha mRNA, participated in its translational upregulation after CoCl(2) ..
  64. ncbi Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas
    Nam Pyo Cho
    Department of Oral Pathology, School of Dentistry and Institute of Oral Bioscience, Chonbuk National University, Jeonju, Korea
    Pathology 39:545-50. 2007
    ..The human embryonic lethal abnormal vision (ELAV)-like protein, HuR, is an mRNA stability protein that can regulate COX-2 expression...
  65. ncbi Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression
    Silvia Niesporek
    Institute of Pathology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, Berlin, Germany
    Int J Oncol 32:341-7. 2008
    The human ELAV-like protein HuR is involved in the stabilization of the mRNAs of a group of genes implicated in the regulation of cellular growth, angiogenesis and rapid inflammatory response...
  66. pmc Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
    Anke Doller
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mol Cell Biol 28:2608-25. 2008
    The mRNA stabilizing factor HuR is involved in the posttranscriptional regulation of many genes, including that coding for cyclooxygenase 2 (COX-2)...
  67. pmc MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90
    Yuki Kuwano
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21228, USA
    Mol Cell Biol 28:4562-75. 2008
    ..Four RNA-binding proteins (RNA-BPs) that influence mRNA turnover and/or translation (HuR, NF90, TIAR, and TIA-1) were found to bind to biotinylated transcripts spanning the MKP-1 AU-rich 3' untranslated ..
  68. pmc HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells
    Julie Lemay
    Institut Cochin, Universite Paris Descartes, CNRS UMR8104, Paris, France
    Retrovirology 5:47. 2008
    ..reverse transcription is affected by the levels of a nucleocytoplasmic shuttling protein - the RNA-binding protein HuR. A direct protein-protein interaction between RT and HuR was observed in a yeast two-hybrid screen and confirmed in ..
  69. pmc RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment
    Chiu Hung Yeh
    Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
    Mol Biol Cell 19:3812-22. 2008
    ..Using RNA probe pulldown assay, HuR was demonstrated to interact with the TM 5'UTR...
  70. pmc Nuclear HuR accumulation through phosphorylation by Cdk1
    Hyeon Ho Kim
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, National Institutes of Health, Baltimore, Maryland 21224, USA
    Genes Dev 22:1804-15. 2008
    A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs...
  71. pmc Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype
    K Mazan-Mamczarz
    Marlene and Stewart Greenebaum Cancer Center, University of Maryland, Baltimore, MD 21201, USA
    Oncogene 27:6151-63. 2008
    ..Using RNA interference to knock down the expression of the RNA-binding protein HuR in MCF7 cells as well as HuR overexpression, we demonstrate that HuR plays an important role in translation of the ..
  72. pmc Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6
    Gary K Scott
    Buck Institute for Age Research, Novato, CA 94945, USA
    Mol Cancer Res 6:1250-8. 2008
    ..Using ERBB2-overexpressing human breast cancer cells (SKBR3), the mRNA stability factor HuR was shown to support ERBB2 transcript integrity, bind and endogenously associate with a conserved U-rich element ..
  73. ncbi Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells
    Christine Hostetter
    Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Camden, New Jersey 08106, USA
    Cancer Biol Ther 7:1496-506. 2008
    ..that inhibition of JNK, a member of the MAPK family, decreases cytoplasmic accumulation of the RNA binding protein HuR. This data combined with previous reports that erbB2/Her2 and IGF-IR signals through JNK, led us to hypothesize ..
  74. pmc Ubiquitin-mediated proteolysis of HuR by heat shock
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, NIA IRP, NIH, Baltimore, MD 21224, USA
    EMBO J 28:1271-82. 2009
    The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins...
  75. doi The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis
    Jun Wang
    Cancer Institute of the People s Liberation Army, Xinqiao Hospital, Third Military Medical University, Chongqing, China
    Oncology 76:420-9. 2009
    The expression levels of the RNA-binding protein Hu antigen (HuR) and vascular endothelial growth factor-C (VEGF-C) were examined immunohistochemically in 81 non-small cell lung cancers (NSCLC) and 15 benign human lung tissues...
  76. pmc B cell lymphoma (Bcl)-2 protein is the major determinant in bcl-2 adenine-uridine-rich element turnover overcoming HuR activity
    Laura Ghisolfi
    Department of Pharmacology, Universita degli Studi di Milano, 20129 Milan
    J Biol Chem 284:20946-55. 2009
    ..In the context of an AUBPs silencing approach, HuR knockdown reduced the expression of endogenous bcl-2, whereas unexpectedly, a bcl-2 ARE-reporter transcript ..
  77. pmc p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint
    Vanesa Lafarga
    CNIO Spanish National Cancer Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Mol Cell Biol 29:4341-51. 2009
    ..In particular, p38 MAPK phosphorylates the mRNA binding protein HuR on Thr118, which results in cytoplasmic accumulation of HuR and its enhanced binding to the p21(Cip1) mRNA...
  78. doi Maturation of the HIV reverse transcription complex: putting the jigsaw together
    David Warrilow
    Division of Infectious Diseases, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    Rev Med Virol 19:324-37. 2009
    ..Determining precisely how these proteins assist the RTC function needs to be addressed...
  79. pmc Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor
    Liang Lu
    Department of Neurology, University of Alabama at Birmingham and the Birmingham Veterans Affairs Medical Center, Birmingham, Alabama 35294, USA
    J Biol Chem 284:33989-98. 2009
    ..Here, we show that the major RNA stabilizer, Hu Antigen R (HuR), and TIA-1-related protein (TIAR) colocalize with mutant SOD1 in mouse spinal cord extracts and cultured ..
  80. pmc MicroRNA-125a represses cell growth by targeting HuR in breast cancer
    Xu Guo
    Department of Cell Biology and Physiology and Cancer Research and Treatment Center, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    RNA Biol 6:575-83. 2009
    ..In this study, we observed that the expression of miR-125a was inversely correlated with HuR expression in several different breast carcinoma cell lines...
  81. doi Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes
    Christina Papadopoulou
    RNA Processing Program, Institute of Biological Research and Biotechnology, National Hellenic Research Foundation, 11635 Athens, Greece
    Biochim Biophys Acta 1804:692-703. 2010
    ..involving hnRNP proteins participating in several steps of mRNA processing (mainly pre-mRNA splicing) and HuR with an established role in stability/translation of associated mRNAs...
  82. pmc Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR
    Anke Doller
    Pharmazentrum frankfurt ZAFES, Klinikum der Johann Wolfgang Goethe Universität Frankfurt am Main, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Mol Cell Biol 30:1397-410. 2010
    Stabilization of mRNA by the ubiquitous RNA binding protein human antigen R (HuR), a member of the embryonic lethal abnormal vision (ELAV) protein family, requires canonical binding to AU-rich element (ARE)-bearing target mRNA and export ..
  83. pmc HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells
    Won Jong Rhee
    Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 107:6858-63. 2010
    ..Here, we show that expression of HuR in human umbilical vein endothelial cells is regulated by shear stress and statin treatment; HuR, in turn, ..
  84. doi Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer
    Jun Wang
    Department of Oncology, General Hospital, Jinan Command of the People s Liberation Army, 250031 Jinan, China
    Med Oncol 28:S577-85. 2011
    b>HuR is a ubiquitously expressed RNA-binding protein that stabilizes the mRNAs of certain genes and regulates the translation to proteins...
  85. pmc Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium
    Jinshui Fan
    Division of Allergy and Clinical Immunology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Immunol 186:2482-94. 2011
    b>HuR is a regulator of mRNA turnover or translation of inflammatory genes through binding to adenylate-uridylate-rich elements and related motifs present in the 3'untranslated region (UTR) of mRNAs...
  86. ncbi Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis
    Zhu Yuan
    Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Heath Park, Cardiff, UK
    Anticancer Res 31:303-10. 2011
    The role of human antigen R (HuR) and its prognostic value in breast cancer is currently only partially understood. This study aimed to determine the levels of expression of HuR in breast cancer and assess its prognostic value.
  87. doi High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells
    Anke Doller
    pharmazentrum frankfurt ZAFES and University of Frankfurt Medical School, Theodor Stern Kai 7, Frankfurt Main, Germany
    Carcinogenesis 32:676-85. 2011
    Overexpression of the messenger RNA (mRNA)-binding protein HuR is an important feature of many tumors and in most cases correlates with a high-grade malignancy...
  88. pmc Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation
    Kiyoshi Masuda
    Laboratory of Molecular Biology and Immunology, Baltimore, MD, USA
    EMBO J 30:1040-53. 2011
    ..Here, we show that survival after IR strongly depends on the checkpoint kinase Chk2 acting upon its substrate HuR, an RNA-binding protein that stabilizes and/or modulates the translation of target mRNAs...
  89. doi HuR-mediated control of C/EBPbeta mRNA stability and translation in ALK-positive anaplastic large cell lymphomas
    Julie Bergalet
    CRCT, INSERM UMR1037, Universite Paul Sabatier, Toulouse, France
    Mol Cancer Res 9:485-96. 2011
    ..By using human ALCL-derived cells and a murine model of ALK-transformed cells, we show that the AU-binding protein HuR binds to the 3'-UTR of C/EBPβ mRNA, as previously reported in adipocytes, and that NPM-ALK enhances this ..
  90. ncbi Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression
    Nicole Claudia Meisner
    Novartis Institutes for BioMedical Research, Novartis Campus, 4002 Basel, Switzerland
    Adv Exp Med Biol 700:106-23. 2010
    ..b>HuR, a ubiquitously expressed member of the ELAV family of RBPs, has been implicated in regulation of stability and ..
  91. pmc Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability
    Neelanjan Mukherjee
    Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA
    Mol Cell 43:327-39. 2011
    ..We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-CLIP, RIP-chip, and ..
  92. pmc Translational control of TOP2A influences doxorubicin efficacy
    Subramanya Srikantan
    Laboratory of Molecular Biology and Immunology, NIA IRP, NIH, Baltimore, Maryland 21224, USA
    Mol Cell Biol 31:3790-801. 2011
    ..Here, we report that the RNA-binding protein HuR, commonly overexpressed in cancers, binds to the TOP2A 3'-untranslated region (3'UTR) and increases TOP2A ..
  93. pmc Posttranscriptional regulation of cancer traits by HuR
    Kotb Abdelmohsen
    LCMB, NIA IRP, NIH, Baltimore, MD 21224, USA
    Wiley Interdiscip Rev RNA 1:214-29. 2010
    ..The RNA-binding protein HuR is highly abundant in many cancers. Numerous HuR-regulated mRNAs encode proteins implicated in carcinogenesis...
  94. pmc The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells
    Dat T Vo
    Greehey Children s Cancer Research Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Mol Cancer Res 10:143-55. 2012
    ..This type of sequence motif is often targeted by HuR, another important RBP known to be highly expressed in tumor tissue such as glioblastoma and to regulate a variety ..
  95. pmc The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation
    Seong Jun Cho
    Center for Comparative Oncology, University of California, Davis, California 95616, USA
    J Biol Chem 287:14535-44. 2012
    The RNA-binding protein HuR, a member of the embryonic lethal abnormal vision/Hu protein family, plays a critical role in many cellular processes, including cell proliferation, angiogenesis, and inflammatory response...
  96. pmc Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells
    Elisa Latorre
    Laboratory of Genomic Screening, Centre for Integrative Biology, CIBIO, University of Trento, Trento, Italy
    Mol Cancer 11:13. 2012
    b>HuR, an RNA binding protein involved in the post-transcriptional regulation of a wide spectrum of mRNAs, has been demonstrated to be a determinant of carcinogenesis and tumor aggressiveness in several cancer types...
  97. pmc β-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells
    Inae Kim
    Department of Molecular Biology, National Research Lab for RNA Cell Biology, BK21 Graduate Program for RNA Biology, Institute of Nanosensor and Biotechnology, Dankook University, Yongin, Gyeonggi do 448 701, Republic of Korea
    Nucleic Acids Res 40:6863-72. 2012
    ..More significantly, the C-terminal domain of β-catenin interacted with HuR and the Armadillo repeat domain associated with RNA to form the RNA-β-catenin-HuR complex in vitro and in cells...
  98. pmc Downregulation of β-actin gene and human antigen R in human keratoconus
    Roy Joseph
    Department of Vision Sciences, University of Alabama at Birmingham, Birmingham, Alabama 35294 4390, USA
    Invest Ophthalmol Vis Sci 53:4032-41. 2012
    ..The purpose of this study was to determine the expression levels and regulation of β-actin in the stroma of keratoconus (KC) and normal corneas...
  99. pmc Dephosphorylation of HuR protein during alphavirus infection is associated with HuR relocalization to the cytoplasm
    Alexa M Dickson
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 287:36229-38. 2012
    We have demonstrated previously that the cellular HuR protein binds U-rich elements in the 3' untranslated region (UTR) of Sindbis virus RNA and relocalizes from the nucleus to the cytoplasm upon Sindbis virus infection in 293T cells...
  100. pmc miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer
    Wijdan Al-Ahmadi
    Molecular Biomedicine Programme, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
    J Pathol 230:28-38. 2013
    ..These proteins include tristetraprolin (TTP, ZFP36) and HuR (ELAVL1), which respectively promote the decay or stability of adenylate-uridylate-rich (AU-rich) mRNAs...
  101. ncbi Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element
    Alexander T Prechtel
    Heinrich Pette Institute for Experimental Virology and Immunology, D 20251 Hamburg, Germany
    J Biol Chem 281:10912-25. 2006
    ..Here, we show that the coding region of CD83 mRNA contains a novel cis-acting structured RNA element that binds to HuR, a member of the ELAV family of AU-rich element RNA-binding proteins...

Research Grants66

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. A role for miRNAs in adenosine-dependent alternative macrophage activation
    Samuel Joseph Leibovich; Fiscal Year: 2013
    ..Conserved overlapping sites for miR-466L and for the RNA binding proteins HuR and TTP are present in the 3'UTR...
  3. MOLECULAR REGULATION OF ILEAL/RENAL BILE ACID TRANSPORT
    Benjamin L Shneider; Fiscal Year: 2012
    ..Aim 2: To test the hypothesis that the RNA binding protein HuR regulates the ontogeny of ASBT via changes in mRNA stability...
  4. Peter H King; Fiscal Year: 2015
    ..The RBP, HuR, plays a major positive role in this molecular pathway by binding to these elements...
  5. RNA Binding Proteins in Cancer
    Shrikant Anant; Fiscal Year: 2013
    ..RBM3 interacts with HuR and hnRNP A1, and with AU-RNA sequences to enhance mRNA stability and translation of AU-rich transcripts such as ..
  6. Post-Transcriptional Regulation in Colorectal Cancer
    DAN ALAN DIXON; Fiscal Year: 2013
    ..two primary RNA-binding proteins associated with post-transcriptional regulation are the mRNA stability factor Hu antigen R (HuR) and the mRNA decay factor tristetraprolin (TTP)...
  7. Posttranscriptional Gene Regulation in Asthma
    Ulus Atasoy; Fiscal Year: 2010
    ..Our central hypothesis is that the RNA binding protein, HuR, is coordinately regulating IL-4 and IL-13 cytokine genes during allergen driven asthma...
  8. Jack D Keene; Fiscal Year: 2015
    ..Weinberg with RAS, telomerase and four other transforming proteins quantify dynamic changes in RNAs associated with HuR (early response gene mRNAs), TIAR (stress granule RNAs) and AGO2/RISC (processing "P" body RNAs)...
  9. FAOUD TERRENCE ISHMAEL; Fiscal Year: 2014
    ..Two RNA binding proteins (RBPs), TTP and HuR appear to play central roles in the inflammatory response: HuR increases mRNA stability and promotes inflammation, ..
  10. VISWANATHAN PALANISAMY; Fiscal Year: 2016
    ..First, among various RNA- binding proteins, HuR is a prominent protein influencing cellular response to stress, proliferative signals, immune triggers, and ..
  11. RNA-binding Protein HuR in Allergic Inflammation
    Cristiana Stellato; Fiscal Year: 2009
    ..relies on the stabilization of the eotaxin mRNA, and that this process involves the cytokine-induced association of HuR to the 3'UTR of eotaxin mRNA...
  12. MOLECULAR MODELS OF IMMUNE-MEDIATED VASCULAR INJURY
    Jeffrey R Bender; Fiscal Year: 2012
    ..sequences, and requires LFA-1 engagement-induced nuclear-to-cytoplasmic translocation of the RNA binding protein HuR. We have also demonstrated that LFA-1-triggered, PI3-kinase- dependent activation of the guanine nucleotide ..
  13. Ulus Atasoy; Fiscal Year: 2016
    ..Our hypothesis is that the RNA binding protein, HuR, is coordinately regulating Th2 polarization and cytokine gene expression in allergic airway inflammation...
  14. OLGA VALERY VOLPERT; Fiscal Year: 2016
    ..expression in UVB/Api-treated keratinocytes occurs post-transcriptionally and is mediated by RNA-binding protein HuR. Importantly, HuR has recently been demonstrated to play an important role in translation of TSP-1 mRNA...
  15. Nutritional Regulation of Leptin Production
    Susan K Fried; Fiscal Year: 2010
    ..The leptin 3'UTR includes AU-rich sequences and motifs for binding of RBPs that are known to stimulate (HuR) or inhibit (TIA-1, TIAR) the translation of specific mRNAs...
  16. Jian Ying Wang; Fiscal Year: 2016
    ..Our preliminary results indicate a) RNA-binding protein (RBP) HuR binds to the occludin mRNA, while HuR silencing represses occludin translation;b) HuR- binding affinity decreases ..
  17. CALLIE PREAST WIGINGTON; Fiscal Year: 2014
    ..may achieve this transcript specificity via another RBP that recognizes specific mRNAs, such as Human Antigen R (HuR), an AU-rich element binding protein already strongly linked to breast cancer...
  18. Control of Renal Glutaminase Expression during Acidosis
    Norman P Curthoys; Fiscal Year: 2012
    ..b>HuR and p40-AUF1 bind to the pHRE with high affinity and specificity...
  19. Post-Transcriptional Mechanisms and Vascular Inflammation
    TIMOTHY TUN HLA; Fiscal Year: 2013
    ..Studies supported by this grant have also shown that the RNA binding protein HuR regulates the COX-2 gene at the post-transcriptional level...
  20. Jian Ying Wang; Fiscal Year: 2016
    ..knockdown of Wnt receptors represses epithelial repair;and c) polyamines modulate RNA-binding proteins TIAR and HuR that are involved in translational control of their target mRNAs...
  21. Dysregulation of VEGF RNA Stability in Amyotrophic Lateral Sclerosis
    Liang Lu; Fiscal Year: 2012
    ..related hypotheses: 1) VEGF destabilization and down-regulation is due to dysfunction of the RNA stabilizer, HuR, in the presence of mutant SOD1...
  22. Katherine L B Borden; Fiscal Year: 2016
    ..to elevate eIF4E levels, through increased eIF4E mRNA stability via interactions with the mRNA stability factor HuR. Like eIF4E, HuR is a potent proto-oncogene...
  23. Raj Kishore; Fiscal Year: 2016
    ..IL-10 inhibits the expression of mRNA stabilizing protein HuR and its ability to bind to TNF-ARE sequences...
  24. Regulation of mRNA stability in Kidney epithelia
    BETH LEE; Fiscal Year: 2009
    ..Investigation into the role of the RNA-stabilizing protein HuR in an in vitro model of renal ischemic injury demonstrated that it is required for maintaining appropriate ..
  25. Ionizing Radiation Control of Inflammatory Cytokine mRNA Stability and Expression
    Robert Schneider; Fiscal Year: 2013
    ..macrophages, and determine the extent to which other ARE-binding proteins such as TTP, KSRP and stabilizing protein HuR are involved in IR-mediated stabilization of inflammatory cytokine ARE-mRNAs...
  26. Transcriptional Regulation and Vascular Protection by IL-10
    Anthony A Cuneo; Fiscal Year: 2012
    ..IL-19 transiently reduces expression of HuR, an inflammatory and proliferative gene mRNA stabilizing protein...
  27. Signaling pathways that regulate IFN-g production in human tuberculosis.
    VERONICA EDITH GARCIA; Fiscal Year: 2012
    ..We will analyze the Ets expression (controls SAP promoter activity) and AUF1/HuR and mRNA stability. 3. Does IL-17 modulate SLAM/CREB activation during IFN-3 regulation in TB? 3.1...
  28. Donna M Driscoll; Fiscal Year: 2016
    ..The data demonstrated that CRABP-II directly associates with HuR, the best characterized regulator of transcript stability in animals from drosophila to man, and that it markedly ..
  29. Translational Regulation in Bronchial Epithelial Cells
    Ann Bin Shyu; Fiscal Year: 2009
    ..After a persistent exposure to IL-4/TNF-α, translocation of HuR, an AU-rich element (ARE) binding protein, from the nucleus to the cytoplasm is elicited in activated bronchial ..
  30. Rajagopal Ramesh; Fiscal Year: 2016
    ..b>HuR, a member of the embryonic lethal abnormal vision (ELAV) protein family, is one such protein that controls the ..
  31. Jennifer S Brodbelt; Fiscal Year: 2016
    ..An in silico database search algorithm, MassMatrixLPS, will be developed by collaborator Hua Xu to facilitate automated, higher-throughput data analysis. 4) Applications to lipid A and LPS of H. pylori, C...
  32. HuR Regulation of HSP 70 in Brain Reperfusion
    JEFFREY SZYMANSKI; Fiscal Year: 2013
    ..Our preliminary data shows nuclear export of the mRNA-stabilizing protein HuR correlates with HSP70 translation. HuR binds ARE-containing mRNAs, and hsp70 mRNA contains an ARE sequence...
  33. Xinmin Simon Xie; Fiscal Year: 2014
    ..The discovery of these lead TP compounds comes from the collaboration among Dr. Hua, a medicinal chemist, Dr. Jin, an AD neuropathology expert, and recently the PI Dr...
  34. Hu proteins as novel splicing regulators in neurons
    Hua Lou; Fiscal Year: 2009
    Lou, Hua Title: Hu proteins as novel splicing regulators in neurons Project Summary: The long-term goal of this project is to understand how alternative splicing is regulated in the mammalian central nervous system (CNS)...
  35. Michael B Kastan; Fiscal Year: 2016
    ..Preliminary data now also implicate the ATM and Chk2 kinases and the HuR translational regulatory protein in this pathway...
  36. Regulation of T Lymphocyte mRNA Degradation
    Paul Bohjanen; Fiscal Year: 2006
    ..The proteins HuA and TTP bind specifically to AREs and thereby regulate mRNA degradation...
  37. Treating type 2 diabetes with menin inhibitors
    Frank Leu; Fiscal Year: 2013
    ..Recent x-ray crystallography work carried out by Dr. Hua and collaborators revealed a potentially druggable pocket in the co-crystal structure of menin bound to a short MLL ..
  38. Suppression of VSMC Activation and Mechanisms of Vascular Protection by IL-19
    Michael V Autieri; Fiscal Year: 2012
    ..induces expression of the suppressor of cytokine signaling 5 (SOCS5), but inhibits expression and translocation of HuR, a stability factor which regulates decay of inflammatory and proliferative gene mRNA...
  39. Pathological interactions of a-syn, mitochondria, and pesticides in PD models
    Michael K Lee; Fiscal Year: 2010
    ..the pathological relationships between mitochondrial dysfunction, oxidative stress and alpha-synucleinopathies in Hua-Syn Tg mice and in cell models (Aims 1 and 2)...
  40. Enhancing ENCODE Through a Transcription Factor Tagging Approach to ChIP-seq
    Kevin P White; Fiscal Year: 2011
    ..2008;Hua, Kittler and White 2009)...
  41. Michael V Autieri; Fiscal Year: 2016
    ..does NOT inhibit NF-kB, but does reduce the stability of inflammatory and proliferative mRNA transcripts in an HuR-dependent manner;4- IL-19 induces expression of the vascular and cyto-protective protein Hemeoxygenase-1 (HO-1), ..
  42. MOLECULAR REGULATION AND ROLE OF PLACENTA GROWTH FACTOR
    Donald S Torry; Fiscal Year: 2010
    ..Aim 3 will investigate functional roles that the mRNA stabilizing proteins, HuR and AUF-1, have in regulating PIGF expression in normal and preeclamptic trophoblast...
  43. Mechanisms directing oncoprotein and cytokine mRNA decay
    Gerald M Wilson; Fiscal Year: 2013
    ..Using the ubiquitously expressed ARE-binding proteins AUF1 and HuR as model systems, we will first characterize specific protein subdomains contributing to ARE binding affinity and ..
  44. TORRY ALLE TUCKER; Fiscal Year: 2016
    ..An advisory committee including Dr. Hua Tang and Dr. Sreerama Shetty resident experts in the field of lung fibrosis and Dr. L...
  45. REGULATION OF HEPATIC HEME METABOLISM
    HERBERT BONKOVSKY; Fiscal Year: 2009
    ..this post-transcriptional effect is mediated by HuR, the protein that plays a critical role in determining mRNA stability;4...
  46. Chitosan Endoluminal Hemostatic Dressing
    Hua Xie; Fiscal Year: 2009
    ..PA-08-051 Chitosan Endoluminal Hemostatic Dressing Project Summary Abstract P.I. - Hua Xie Page 1 Co-PI - Simon McCarthy Abstract The goal of this proposal is to demonstrate Phase I feasibility of a ..
  47. Stem cells as vehicles for therapeutic nanoparticle delivery to breast cancer
    Deryl Troyer; Fiscal Year: 2009
    ..b>Hua (co- investigator) at Kansas State University), Doxorubricin, and Cisplatin is polyethylene glycol- ..
  48. Chemoprevention of Early Pulmonary Lesions in Mice
    ALVIN MALKINSON; Fiscal Year: 2004
    ..These include pro-inflammatory enzymes (COX-1, COX-2, and iNOS) and hnRNP proteins (AUF1 , HuR, and A1)...
  49. XIAO HUA A ZHOU; Fiscal Year: 2016
    ..D. degrees in the Department of Biostatistics. This training program will be co-directed by Xiao-Hua (Andrew) Zhou, Ph.D., a Professor in the Department of Biostatistics, and Wayne Katon, M.D...
  50. RIBONUCLEOTIDE REDUCTASE GENES OF WT AND HUR POXVIRUS
    MARY SLABAUGH; Fiscal Year: 1990
    ..These studies are designed to evaluate the role of ribonucleotide reductase in replicating systems, and ultimately to ask whether this enzyme has a role in tumorigenesis...
  51. Adrenergic Receptor Mechanisms in Antidepressant Therapy
    CURTIS MACHIDA; Fiscal Year: 2004
    ..Firstly, we have recently determined that the RNA binding factors HuR, hnRNP A1, and AUF-1 all interact with the 3' untranslated region (UTR) of the rat 61- AR mRNAs, and that HuR ..
  52. DEREGULATION BY HU PROTEINS IN LUNG CANCER
    Ite Laird Offringa; Fiscal Year: 2002
    ..HuD, HuC and Hel-N1 are expressed in neuronal tissue, while HuR is expressed ubiquitously...
  53. PLA2 activation by mast cell tryptase in IC
    Jane McHowat; Fiscal Year: 2007
    ..The specific aims to test this hypothesis are: 1. To determine whether tryptase stimulation of human urothelial (HUR) cells contributes to the propagation of the inflammatory process by increasing PLA2 activity and production of ..
  54. Antidepressant Treatment and Suicidality: Biostatistical/Methodological Solutions
    Robert Gibbons; Fiscal Year: 2006
    ..The multidisciplinary group includes the areas of statistics (Drs. Gibbons, (PI), Brown (co-Pi), Bhaumik, Duan, Hur, Marcus, SahaRay), psychiatry from adult, child, and genetic perspectives (Brent, Mann, Reynolds, Tsuang), health ..
  55. DEVELOPMENT OF INTESTINAL TRANSPORT OF CA++ AND PI
    Fayez Ghishan; Fiscal Year: 2007
    ..Ghishan, M.D P.I. James F. Collins, Ph.D. Co P.I. Shougang Zhuang, M.D Res Asst Prof Hua Xu Res Specialist Sr PHS 398 (Rev...
  56. POSTTRANSCRIPTIONAL GENE REGULATION IN T CELL ACTIVATION
    JACK KEENE; Fiscal Year: 2004
    ..We will focus on the role of the ELAV/Hu proteins in T cells by production of HuR-deficient mice using the cre/lox mediated T cell knockout procedure...
  57. RNA-BP in Regulation of T Lymphocyte Activation
    Paul Bohjanen; Fiscal Year: 2004
    ..focuses on characterizing the regulation and function of the ARE-binding proteins tristetraprolin (TTP) and HuA proteins in T lymphocytes...
  58. Post-transcriptional regulation of TNF-alpha production
    Paul Anderson; Fiscal Year: 2005
    ..g. TIA-l and TIAR), rnRNA stabilizers (e.g. HuR) and mRNA destabilizers (e.g. AUF1 and TTP)...
  59. REGULATION OF VEGF MRNA STABILITY BY HYPOXIA
    Henry Furneaux; Fiscal Year: 2002
    ..They have also identified a trans acting factor (HuR) that binds to this element and increases the expression of VEGF...
  60. Development of pp32 Gene Family-Based Cancer Diagnostics
    JAMES LAZAR; Fiscal Year: 2003
    ..APRIL was isolated as part of the complex with HuR. A number of clinical studies suggest that pp32, pp32rl, and pp32r2 may be useful markers in establishing the ..
  61. Post-transcriptional Regulation Requires Phosphorylation of HuR in Glioma
    LOUIS NABORS; Fiscal Year: 2009
    ..at the top of each printed page and each continuation page. RESEARCH GRANT TABLE OF CONTENTS Page Numbers Face Page 1 Description, ..
  62. Aberrant VEGF RNA Stability in Amyotrophic Lateral Sclerosis
    Peter King; Fiscal Year: 2008
    ..We will also test whether the RNA stabilizer, HuR, can reverse the mutant SOD1-induced destabilization of VEGF RNA...