HuR

Summary

Gene Symbol: HuR
Description: ELAV like RNA binding protein 1
Alias: ELAV1, HUR, Hua, MelG, ELAV-like protein 1, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R), Hu antigen R, embryonic lethal, abnormal vision, drosophila, homolog-like 1, hu-antigen R
Species: human
Products:     HuR

Top Publications

  1. Suswam E, Nabors L, Huang Y, Yang X, King P. IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3' untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. Int J Cancer. 2005;113:911-9 pubmed
    ..Immunoprecipitation analysis indicated that HuR, KSRP and TIAR bound to one or more loci in the 3'UTR...
  2. Wang J, Collinge M, Ramgolam V, Ayalon O, Fan X, Pardi R, et al. LFA-1-dependent HuR nuclear export and cytokine mRNA stabilization in T cell activation. J Immunol. 2006;176:2105-13 pubmed
    ..T cell stimulation by LFA-1 promotes rapid nuclear-to-cytoplasmic translocation of the mRNA-stabilizing protein HuR, which in turn is capable of binding an AU-rich element sequence in vitro...
  3. Masuda K, Abdelmohsen K, Kim M, Srikantan S, Lee E, Tominaga K, et al. Global dissociation of HuR-mRNA complexes promotes cell survival after ionizing radiation. EMBO J. 2011;30:1040-53 pubmed publisher
    ..Here, we show that survival after IR strongly depends on the checkpoint kinase Chk2 acting upon its substrate HuR, an RNA-binding protein that stabilizes and/or modulates the translation of target mRNAs...
  4. Fialcowitz White E, Brewer B, Ballin J, Willis C, Toth E, Wilson G. Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences. J Biol Chem. 2007;282:20948-59 pubmed
    The RNA-binding factor HuR is a ubiquitously expressed member of the Hu protein family that binds and stabilizes mRNAs containing AU-rich elements (AREs)...
  5. Dormoy Raclet V, Ménard I, Clair E, Kurban G, Mazroui R, Di Marco S, et al. The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Mol Cell Biol. 2007;27:5365-80 pubmed
    ..Here we show that the RNA-binding protein HuR stabilizes the beta-actin mRNA by associating with a uridine-rich element within its 3' untranslated region...
  6. Yuan Z, Sanders A, Ye L, Wang Y, Jiang W. Prognostic value of the human antigen R (HuR) in human breast cancer: high level predicts a favourable prognosis. Anticancer Res. 2011;31:303-10 pubmed
    The role of human antigen R (HuR) and its prognostic value in breast cancer is currently only partially understood. This study aimed to determine the levels of expression of HuR in breast cancer and assess its prognostic value...
  7. Wang W, Yang X, Kawai T, Lopez de Silanes I, Mazan Mamczarz K, Chen P, et al. AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. J Biol Chem. 2004;279:48376-88 pubmed
    Nuclear import of HuR, a shuttling RNA-binding protein, is associated with reduced stability of its target mRNAs...
  8. Rhee W, Ni C, Zheng Z, Chang K, Jo H, Bao G. HuR regulates the expression of stress-sensitive genes and mediates inflammatory response in human umbilical vein endothelial cells. Proc Natl Acad Sci U S A. 2010;107:6858-63 pubmed publisher
    ..Here, we show that expression of HuR in human umbilical vein endothelial cells is regulated by shear stress and statin treatment; HuR, in turn, ..
  9. Mukherjee N, Corcoran D, Nusbaum J, Reid D, Georgiev S, Hafner M, et al. Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. Mol Cell. 2011;43:327-39 pubmed publisher
    ..We elucidated regulatory mechanisms of the RNA-binding protein HuR, by integrating data from diverse high-throughput targeting technologies, specifically PAR-CLIP, RIP-chip, and ..

More Information

Publications100

  1. Lebedeva S, Jens M, Theil K, Schwanhäusser B, Selbach M, Landthaler M, et al. Transcriptome-wide analysis of regulatory interactions of the RNA-binding protein HuR. Mol Cell. 2011;43:340-52 pubmed publisher
    ..The human RBP HuR/ELAVL1 is a conserved mRNA stability regulator...
  2. Wang W, Fan J, Yang X, Fürer Galban S, Lopez de Silanes I, Von Kobbe C, et al. AMP-activated kinase regulates cytoplasmic HuR. Mol Cell Biol. 2002;22:3425-36 pubmed
    While transport of RNA-binding protein HuR from nucleus to cytoplasm is emerging as a key regulatory step for HuR function, the mechanisms underlying this process remain poorly understood...
  3. Al Ahmadi W, Al Ghamdi M, Al Souhibani N, Khabar K. miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer. J Pathol. 2013;230:28-38 pubmed publisher
    ..These proteins include tristetraprolin (TTP, ZFP36) and HuR (ELAVL1), which respectively promote the decay or stability of adenylate-uridylate-rich (AU-rich) mRNAs...
  4. Joseph R, Srivastava O, Pfister R. Downregulation of ?-actin gene and human antigen R in human keratoconus. Invest Ophthalmol Vis Sci. 2012;53:4032-41 pubmed publisher
    ..The human antigen R (HuR) gene expression was analyzed by real-time PCR in the stroma of five KC and five normal corneas...
  5. Rajasingh J, Bord E, Luedemann C, Asai J, Hamada H, Thorne T, et al. IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J. 2006;20:2112-4 pubmed
    ..IL-10 sensitivity to TNF depends on the ability of IL-10 to inhibit the expression and mRNA-stabilizing protein HuR and via IL-10 mediated repression of p38 mitogen-activated protein (MAP) kinase activation...
  6. Abdelmohsen K, Srikantan S, Yang X, Lal A, Kim H, Kuwano Y, et al. Ubiquitin-mediated proteolysis of HuR by heat shock. EMBO J. 2009;28:1271-82 pubmed publisher
    The RNA-binding protein HuR regulates the stability and translation of numerous mRNAs encoding stress-response and proliferative proteins...
  7. Warrilow D, Tachedjian G, Harrich D. Maturation of the HIV reverse transcription complex: putting the jigsaw together. Rev Med Virol. 2009;19:324-37 pubmed publisher
    ..Determining precisely how these proteins assist the RTC function needs to be addressed. ..
  8. Papadopoulou C, Patrinou Georgoula M, Guialis A. Extensive association of HuR with hnRNP proteins within immunoselected hnRNP and mRNP complexes. Biochim Biophys Acta. 2010;1804:692-703 pubmed publisher
    ..involving hnRNP proteins participating in several steps of mRNA processing (mainly pre-mRNA splicing) and HuR with an established role in stability/translation of associated mRNAs...
  9. Atasoy U, Curry S, Lopez de Silanes I, Shyu A, Casolaro V, Gorospe M, et al. Regulation of eotaxin gene expression by TNF-alpha and IL-4 through mRNA stabilization: involvement of the RNA-binding protein HuR. J Immunol. 2003;171:4369-78 pubmed
    ..Evidence that the mRNA-stabilizing protein HuR participated in the cytokine effect was obtained: first, HuR presence in the cytoplasm, believed to be required for ..
  10. Lafarga V, Cuadrado A, Lopez de Silanes I, Bengoechea R, Fernandez Capetillo O, Nebreda A. p38 Mitogen-activated protein kinase- and HuR-dependent stabilization of p21(Cip1) mRNA mediates the G(1)/S checkpoint. Mol Cell Biol. 2009;29:4341-51 pubmed publisher
    ..In particular, p38 MAPK phosphorylates the mRNA binding protein HuR on Thr118, which results in cytoplasmic accumulation of HuR and its enhanced binding to the p21(Cip1) mRNA...
  11. Sureban S, Murmu N, Rodriguez P, May R, Maheshwari R, Dieckgraefe B, et al. Functional antagonism between RNA binding proteins HuR and CUGBP2 determines the fate of COX-2 mRNA translation. Gastroenterology. 2007;132:1055-65 pubmed
    ..Although structurally homologous RNA binding proteins HuR and CUGBP2 stabilize COX-2 mRNA, HuR induces whereas CUGBP2 inhibits COX-2 mRNA translation...
  12. Ray D, Kazan H, Chan E, Pena Castillo L, Chaudhry S, Talukder S, et al. Rapid and systematic analysis of the RNA recognition specificities of RNA-binding proteins. Nat Biotechnol. 2009;27:667-70 pubmed publisher
    ..We tested RNAcompete by analyzing nine diverse RBPs (HuR, Vts1, FUSIP1, PTB, U1A, SF2/ASF, SLM2, RBM4 and YB1)...
  13. Rebane A, Aab A, Steitz J. Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. RNA. 2004;10:590-9 pubmed
    Several mRNA-binding proteins, including hnRNP A1 and HuR, contain bidirectional transport signals that mediate both their nuclear import and export...
  14. Lal A, Mazan Mamczarz K, Kawai T, Yang X, Martindale J, Gorospe M. Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs. EMBO J. 2004;23:3092-102 pubmed
    RNA-binding proteins HuR and AUF1 bind to many common AU-rich target mRNAs and exert opposing influence on target mRNA stability, but the functional interactions between HuR and AUF1 have not been systematically studied...
  15. Wang W, Yang X, Lopez de Silanes I, Carling D, Gorospe M. Increased AMP:ATP ratio and AMP-activated protein kinase activity during cellular senescence linked to reduced HuR function. J Biol Chem. 2003;278:27016-23 pubmed
    Cytoplasmic export of the RNA-binding protein HuR, a process that critically regulates its function, was recently shown to be inhibited by the AMP-activated protein kinase (AMPK)...
  16. Lal A, Kawai T, Yang X, Mazan Mamczarz K, Gorospe M. Antiapoptotic function of RNA-binding protein HuR effected through prothymosin alpha. EMBO J. 2005;24:1852-62 pubmed
    We report the antiapoptotic effect of RNA-binding protein HuR, a critical regulator of the post-transcriptional fate of target transcripts...
  17. Wang J, Wang B, Bi J, Zhang C. Cytoplasmic HuR expression correlates with angiogenesis, lymphangiogenesis, and poor outcome in lung cancer. Med Oncol. 2011;28 Suppl 1:S577-85 pubmed publisher
    b>HuR is a ubiquitously expressed RNA-binding protein that stabilizes the mRNAs of certain genes and regulates the translation to proteins...
  18. Gallouzi I, Brennan C, Steitz J. Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock. RNA. 2001;7:1348-61 pubmed
    ..b>HuR, an RRM-containing RNA-binding protein, specifically interacts with AREs, stabilizing these mRNAs...
  19. Güttinger S, Mühlhäusser P, Koller Eichhorn R, Brennecke J, Kutay U. Transportin2 functions as importin and mediates nuclear import of HuR. Proc Natl Acad Sci U S A. 2004;101:2918-23 pubmed
    ..As expected of an import complex, RanGTP also disrupted the interaction between TRN2 and HuR, an RNA-binding protein previously described as a TRN2 export substrate...
  20. Fries B, Heukeshoven J, Hauber I, Grüttner C, Stocking C, Kehlenbach R, et al. Analysis of nucleocytoplasmic trafficking of the HuR ligand APRIL and its influence on CD83 expression. J Biol Chem. 2007;282:4504-15 pubmed
    ..It has been recently shown that CD83 mRNA is transported from the nucleus to the cytoplasm in a HuR- and CRM1-dependent manner...
  21. Uren P, Burns S, Ruan J, Singh K, Smith A, Penalva L. Genomic analyses of the RNA-binding protein Hu antigen R (HuR) identify a complex network of target genes and novel characteristics of its binding sites. J Biol Chem. 2011;286:37063-6 pubmed publisher
    The ubiquitously expressed RNA-binding protein Hu antigen R (HuR) or ELAVL1 is implicated in a variety of biological processes as well as being linked with a number of diseases, including cancer...
  22. Meng Z, King P, Nabors L, Jackson N, Chen C, Emanuel P, et al. The ELAV RNA-stability factor HuR binds the 5'-untranslated region of the human IGF-IR transcript and differentially represses cap-dependent and IRES-mediated translation. Nucleic Acids Res. 2005;33:2962-79 pubmed
    ..Here, we report the purification and identification of one of these IGF-IR 5'-UTR-binding proteins as HuR, using a novel RNA crosslinking/RNase elution strategy...
  23. Abdelmohsen K, Gorospe M. Posttranscriptional regulation of cancer traits by HuR. Wiley Interdiscip Rev RNA. 2010;1:214-29 pubmed publisher
    ..The RNA-binding protein HuR is highly abundant in many cancers. Numerous HuR-regulated mRNAs encode proteins implicated in carcinogenesis...
  24. Niesporek S, Kristiansen G, Thoma A, Weichert W, Noske A, Buckendahl A, et al. Expression of the ELAV-like protein HuR in human prostate carcinoma is an indicator of disease relapse and linked to COX-2 expression. Int J Oncol. 2008;32:341-7 pubmed
    The human ELAV-like protein HuR is involved in the stabilization of the mRNAs of a group of genes implicated in the regulation of cellular growth, angiogenesis and rapid inflammatory response...
  25. Amadio M, Scapagnini G, Laforenza U, Intrieri M, Romeo L, Govoni S, et al. Post-transcriptional regulation of HSP70 expression following oxidative stress in SH-SY5Y cells: the potential involvement of the RNA-binding protein HuR. Curr Pharm Des. 2008;14:2651-8 pubmed
    ..In the present report we show that the RNA-binding protein ELAV/HuR can affect, post-transcriptionally, the fate of HSP70 mRNA following H(2)O(2)-mediated oxidative stress in SH-SY5Y ..
  26. Li H, Park S, Kilburn B, Jelinek M, Henschen Edman A, Aswad D, et al. Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1. Coactivator-associated arginine methyltransferase. J Biol Chem. 2002;277:44623-30 pubmed
    The RNA-binding protein HuR stabilizes labile mRNAs carrying AU-rich instability elements. This mRNA stabilization can be induced by hypoxia, lipopolysaccharide, and UV light...
  27. Srikantan S, Abdelmohsen K, Lee E, Tominaga K, Subaran S, Kuwano Y, et al. Translational control of TOP2A influences doxorubicin efficacy. Mol Cell Biol. 2011;31:3790-801 pubmed publisher
    ..Here, we report that the RNA-binding protein HuR, commonly overexpressed in cancers, binds to the TOP2A 3'-untranslated region (3'UTR) and increases TOP2A ..
  28. Yeh C, Hung L, Hsu C, LE S, Lee P, Liao W, et al. RNA-binding protein HuR interacts with thrombomodulin 5'untranslated region and represses internal ribosome entry site-mediated translation under IL-1 beta treatment. Mol Biol Cell. 2008;19:3812-22 pubmed publisher
    ..Using RNA probe pulldown assay, HuR was demonstrated to interact with the TM 5'UTR...
  29. Lal S, Burkhart R, Beeharry N, Bhattacharjee V, Londin E, Cozzitorto J, et al. HuR posttranscriptionally regulates WEE1: implications for the DNA damage response in pancreatic cancer cells. Cancer Res. 2014;74:1128-40 pubmed publisher
    HuR (ELAV1), an RNA-binding protein abundant in cancer cells, primarily resides in the nucleus, but under specific stress (e.g...
  30. Meisner N, Hintersteiner M, Mueller K, Bauer R, Seifert J, Naegeli H, et al. Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR. Nat Chem Biol. 2007;3:508-15 pubmed
    ..the identification and mechanistic characterization of the first low-molecular-weight inhibitors for Hu protein R (HuR) from microbial broths (Actinomyces sp.): dehydromutactin (1), MS-444 (2) and okicenone (3)...
  31. Filippova N, Yang X, Wang Y, Gillespie G, Langford C, King P, et al. The RNA-binding protein HuR promotes glioma growth and treatment resistance. Mol Cancer Res. 2011;9:648-59 pubmed publisher
    ..We previously found that the mRNA-binding protein, ELAV 1 (HuR), is upregulated in primary brain tumors and stabilizes growth factor mRNAs such as VEGF and IL-8...
  32. Chen C, Xu N, Shyu A. Highly selective actions of HuR in antagonizing AU-rich element-mediated mRNA destabilization. Mol Cell Biol. 2002;22:7268-78 pubmed
    Human RNA-binding protein HuR, a nucleocytoplasmic shuttling protein, is a ubiquitously expressed member of the family of Hu proteins, which consist of two N-terminal RNA recognition motifs (RRM1 and RRM2), a hinge region, and a C-..
  33. Farooq F, Balabanian S, Liu X, Holcik M, MacKenzie A. p38 Mitogen-activated protein kinase stabilizes SMN mRNA through RNA binding protein HuR. Hum Mol Genet. 2009;18:4035-45 pubmed publisher
    ..We demonstrate that Anisomycin activation of p38 causes a rapid cytoplasmic accumulation of HuR, a RNA binding protein which binds to and stabilizes the AU-rich element within the SMN transcript...
  34. Mazan Mamczarz K, Hagner P, Corl S, Srikantan S, Wood W, Becker K, et al. Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. Oncogene. 2008;27:6151-63 pubmed publisher
    ..Using RNA interference to knock down the expression of the RNA-binding protein HuR in MCF7 cells as well as HuR overexpression, we demonstrate that HuR plays an important role in translation of the ..
  35. Kuwano Y, Kim H, Abdelmohsen K, Pullmann R, Martindale J, Yang X, et al. MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90. Mol Cell Biol. 2008;28:4562-75 pubmed publisher
    ..Four RNA-binding proteins (RNA-BPs) that influence mRNA turnover and/or translation (HuR, NF90, TIAR, and TIA-1) were found to bind to biotinylated transcripts spanning the MKP-1 AU-rich 3' untranslated ..
  36. Lopez de Silanes I, Fan J, Yang X, Zonderman A, Potapova O, Pizer E, et al. Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene. 2003;22:7146-54 pubmed
    ..tumor and normal tissue specimens revealed that the expression and cytoplasmic abundance of the RNA-binding protein HuR increased with malignancy, particularly in colon carcinomas...
  37. Fan J, Ishmael F, Fang X, Myers A, Cheadle C, Huang S, et al. Chemokine transcripts as targets of the RNA-binding protein HuR in human airway epithelium. J Immunol. 2011;186:2482-94 pubmed publisher
    b>HuR is a regulator of mRNA turnover or translation of inflammatory genes through binding to adenylate-uridylate-rich elements and related motifs present in the 3'untranslated region (UTR) of mRNAs...
  38. Vo D, Abdelmohsen K, Martindale J, Qiao M, Tominaga K, Burton T, et al. The oncogenic RNA-binding protein Musashi1 is regulated by HuR via mRNA translation and stability in glioblastoma cells. Mol Cancer Res. 2012;10:143-55 pubmed publisher
    ..This type of sequence motif is often targeted by HuR, another important RBP known to be highly expressed in tumor tissue such as glioblastoma and to regulate a variety ..
  39. Meisner N, Filipowicz W. Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression. Adv Exp Med Biol. 2010;700:106-23 pubmed
    ..b>HuR, a ubiquitously expressed member of the ELAV family of RBPs, has been implicated in regulation of stability and ..
  40. Mazroui R, Di Marco S, Clair E, von Roretz C, Tenenbaum S, Keene J, et al. Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. J Cell Biol. 2008;180:113-27 pubmed publisher
    The RNA-binding protein HuR affects cell fate by regulating the stability and/or the translation of messenger RNAs that encode cell stress response proteins...
  41. Cho S, Jung Y, Zhang J, Chen X. The RNA-binding protein RNPC1 stabilizes the mRNA encoding the RNA-binding protein HuR and cooperates with HuR to suppress cell proliferation. J Biol Chem. 2012;287:14535-44 pubmed publisher
    The RNA-binding protein HuR, a member of the embryonic lethal abnormal vision/Hu protein family, plays a critical role in many cellular processes, including cell proliferation, angiogenesis, and inflammatory response...
  42. Abdelmohsen K, Pullmann R, Lal A, Kim H, Galban S, Yang X, et al. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell. 2007;25:543-57 pubmed
    The RNA binding protein HuR regulates the stability of many target mRNAs...
  43. Prechtel A, Chemnitz J, Schirmer S, Ehlers C, Langbein Detsch I, Stülke J, et al. Expression of CD83 is regulated by HuR via a novel cis-active coding region RNA element. J Biol Chem. 2006;281:10912-25 pubmed
    ..Here, we show that the coding region of CD83 mRNA contains a novel cis-acting structured RNA element that binds to HuR, a member of the ELAV family of AU-rich element RNA-binding proteins...
  44. Doller A, Winkler C, Azrilian I, Schulz S, Hartmann S, Pfeilschifter J, et al. High-constitutive HuR phosphorylation at Ser 318 by PKC{delta} propagates tumor relevant functions in colon carcinoma cells. Carcinogenesis. 2011;32:676-85 pubmed publisher
    Overexpression of the messenger RNA (mRNA)-binding protein HuR is an important feature of many tumors and in most cases correlates with a high-grade malignancy...
  45. Lopez de Silanes I, Lal A, Gorospe M. HuR: post-transcriptional paths to malignancy. RNA Biol. 2005;2:11-3 pubmed
    The RNA-binding protein HuR regulates the stability and translation of target mRNAs...
  46. Doller A, Schlepckow K, Schwalbe H, Pfeilschifter J, Eberhardt W. Tandem phosphorylation of serines 221 and 318 by protein kinase Cdelta coordinates mRNA binding and nucleocytoplasmic shuttling of HuR. Mol Cell Biol. 2010;30:1397-410 pubmed publisher
    Stabilization of mRNA by the ubiquitous RNA binding protein human antigen R (HuR), a member of the embryonic lethal abnormal vision (ELAV) protein family, requires canonical binding to AU-rich element (ARE)-bearing target mRNA and export ..
  47. Dickson A, Anderson J, Barnhart M, Sokoloski K, Oko L, Opyrchal M, et al. Dephosphorylation of HuR protein during alphavirus infection is associated with HuR relocalization to the cytoplasm. J Biol Chem. 2012;287:36229-38 pubmed publisher
    We have demonstrated previously that the cellular HuR protein binds U-rich elements in the 3' untranslated region (UTR) of Sindbis virus RNA and relocalizes from the nucleus to the cytoplasm upon Sindbis virus infection in 293T cells...
  48. Cok S, Acton S, Morrison A. The proximal region of the 3'-untranslated region of cyclooxygenase-2 is recognized by a multimeric protein complex containing HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U. J Biol Chem. 2003;278:36157-62 pubmed
    ..We identified four members of the protein-RNA complex as HuR, TIA-1, TIAR, and the heterogeneous nuclear ribonucleoprotein U (hnRNP U)...
  49. David P, Tanveer R, Port J. FRET-detectable interactions between the ARE binding proteins, HuR and p37AUF1. RNA. 2007;13:1453-68 pubmed
    ..Two ARE binding proteins, HuR and AUF1, are associated with mRNA stabilization and destabilization, respectively...
  50. Mazan Mamczarz K, Galban S, Lopez de Silanes I, Martindale J, Atasoy U, Keene J, et al. RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci U S A. 2003;100:8354-9 pubmed
    ..The 3' UTR of p53 was found to be a target of the RNA-binding protein HuR in a UVC-dependent manner in vitro and in vivo...
  51. Spångberg K, Wiklund L, Schwartz S. HuR, a protein implicated in oncogene and growth factor mRNA decay, binds to the 3' ends of hepatitis C virus RNA of both polarities. Virology. 2000;274:378-90 pubmed
    ..Two of these proteins were identified as the ELAV-like HuR protein and hnRNP C...
  52. Wang J, Zhao W, Guo Y, Zhang B, Xie Q, Xiang D, et al. The expression of RNA-binding protein HuR in non-small cell lung cancer correlates with vascular endothelial growth factor-C expression and lymph node metastasis. Oncology. 2009;76:420-9 pubmed publisher
    The expression levels of the RNA-binding protein Hu antigen (HuR) and vascular endothelial growth factor-C (VEGF-C) were examined immunohistochemically in 81 non-small cell lung cancers (NSCLC) and 15 benign human lung tissues...
  53. St Laurent G, Shtokalo D, Heydarian M, Palyanov A, Babiy D, Zhou J, et al. Insights from the HuR-interacting transcriptome: ncRNAs, ubiquitin pathways, and patterns of secondary structure dependent RNA interactions. Mol Genet Genomics. 2012;287:867-79 pubmed publisher
    The HuR protein regulates the expression of thousands of cellular transcripts by modulating mRNA splicing, trafficking, translation, and stability...
  54. Akaike Y, Masuda K, Kuwano Y, Nishida K, Kajita K, Kurokawa K, et al. HuR regulates alternative splicing of the TRA2? gene in human colon cancer cells under oxidative stress. Mol Cell Biol. 2014;34:2857-73 pubmed publisher
    b>Hu antigen R (HuR) regulates stress responses through stabilizing and/or facilitating the translation of target mRNAs...
  55. Jeyaraj S, Dakhlallah D, Hill S, Lee B. Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells. Am J Physiol Renal Physiol. 2006;291:F1255-63 pubmed
    Human antigen R (HuR) is a nucleocytoplasmic shuttling protein that binds to and stabilizes mRNAs containing adenine- and uridine-rich elements...
  56. Saunus J, French J, Edwards S, Beveridge D, Hatchell E, Wagner S, et al. Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR. Cancer Res. 2008;68:9469-78 pubmed publisher
    ..BRCA1 is posttranscriptionally regulated by RNA-binding proteins, the identities of which are unknown. HuR is an RNA binding protein implicated in posttranscriptional regulation of many genes and is overexpressed in ..
  57. Hostetter C, Licata L, Witkiewicz A, Costantino C, Yeo C, Brody J, et al. Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells. Cancer Biol Ther. 2008;7:1496-506 pubmed
    ..that inhibition of JNK, a member of the MAPK family, decreases cytoplasmic accumulation of the RNA binding protein HuR. This data combined with previous reports that erbB2/Her2 and IGF-IR signals through JNK, led us to hypothesize ..
  58. Guo X, Hartley R. HuR contributes to cyclin E1 deregulation in MCF-7 breast cancer cells. Cancer Res. 2006;66:7948-56 pubmed
    ..We show here that the mRNA-binding protein HuR increases cyclin E1 mRNA stability in MCF-7 breast carcinoma cells...
  59. Doller A, Huwiler A, Müller R, Radeke H, Pfeilschifter J, Eberhardt W. Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2. Mol Biol Cell. 2007;18:2137-48 pubmed
    ..ATP analogue adenosine-5'-O-(3-thio)triphosphate-induced nucleocytoplasmic shuttling of the mRNA stabilizing factor HuR in human (h) mesangial cells (MC)...
  60. Abdelmohsen K, Lal A, Kim H, Gorospe M. Posttranscriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle. 2007;6:1288-92 pubmed
    The RNA-binding protein HuR can stabilize and/or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents...
  61. Gallouzi I, Steitz J. Delineation of mRNA export pathways by the use of cell-permeable peptides. Science. 2001;294:1895-901 pubmed
    ..We show that HuR, a protein implicated in the stabilization of short-lived mRNAs containing AU-rich elements (AREs), serves as an ..
  62. Doller A, Akool E, Huwiler A, Müller R, Radeke H, Pfeilschifter J, et al. Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA. Mol Cell Biol. 2008;28:2608-25 pubmed publisher
    The mRNA stabilizing factor HuR is involved in the posttranscriptional regulation of many genes, including that coding for cyclooxygenase 2 (COX-2)...
  63. Kim I, Kwak H, Lee H, Hyun S, Jeong S. ?-Catenin recognizes a specific RNA motif in the cyclooxygenase-2 mRNA 3'-UTR and interacts with HuR in colon cancer cells. Nucleic Acids Res. 2012;40:6863-72 pubmed publisher
    ..More significantly, the C-terminal domain of ?-catenin interacted with HuR and the Armadillo repeat domain associated with RNA to form the RNA-?-catenin-HuR complex in vitro and in cells...
  64. Pullmann R, Juhaszova M, Lopez de Silanes I, Kawai T, Mazan Mamczarz K, Halushka M, et al. Enhanced proliferation of cultured human vascular smooth muscle cells linked to increased function of RNA-binding protein HuR. J Biol Chem. 2005;280:22819-26 pubmed
    In dividing cells, the RNA-binding protein HuR associates with and stabilizes labile mRNAs encoding proliferative proteins, events that are linked to the increased cytoplasmic presence of HuR...
  65. Bergalet J, Fawal M, Lopez C, Desjobert C, Lamant L, Delsol G, et al. HuR-mediated control of C/EBPbeta mRNA stability and translation in ALK-positive anaplastic large cell lymphomas. Mol Cancer Res. 2011;9:485-96 pubmed publisher
    ..By using human ALCL-derived cells and a murine model of ALK-transformed cells, we show that the AU-binding protein HuR binds to the 3'-UTR of C/EBP? mRNA, as previously reported in adipocytes, and that NPM-ALK enhances this ..
  66. Galban S, Kuwano Y, Pullmann R, Martindale J, Kim H, Lal A, et al. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008;28:93-107 pubmed
    ..Instead, we postulated that RNA-binding proteins HuR and PTB, previously shown to bind HIF-1alpha mRNA, participated in its translational upregulation after CoCl(2) ..
  67. Cho N, Han H, Soh Y, Lee K, Son H. Cytoplasmic HuR over-expression is associated with increased cyclooxygenase-2 expression in laryngeal squamous cell carcinomas. Pathology. 2007;39:545-50 pubmed
    ..The human embryonic lethal abnormal vision (ELAV)-like protein, HuR, is an mRNA stability protein that can regulate COX-2 expression...
  68. Latorre E, Tebaldi T, Viero G, Spartà A, Quattrone A, Provenzani A. Downregulation of HuR as a new mechanism of doxorubicin resistance in breast cancer cells. Mol Cancer. 2012;11:13 pubmed publisher
    b>HuR, an RNA binding protein involved in the post-transcriptional regulation of a wide spectrum of mRNAs, has been demonstrated to be a determinant of carcinogenesis and tumor aggressiveness in several cancer types...
  69. Tran H, Maurer F, Nagamine Y. Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Mol Cell Biol. 2003;23:7177-88 pubmed
    ..We show here that the mRNA-stabilizing factor HuR functionally interacts with these sequences...
  70. Lemay J, Maidou Peindara P, Bader T, Ennifar E, Rain J, Benarous R, et al. HuR interacts with human immunodeficiency virus type 1 reverse transcriptase, and modulates reverse transcription in infected cells. Retrovirology. 2008;5:47 pubmed publisher
    ..reverse transcription is affected by the levels of a nucleocytoplasmic shuttling protein - the RNA-binding protein HuR. A direct protein-protein interaction between RT and HuR was observed in a yeast two-hybrid screen and confirmed in ..
  71. Guo X, Wu Y, Hartley R. MicroRNA-125a represses cell growth by targeting HuR in breast cancer. RNA Biol. 2009;6:575-83 pubmed
    ..In this study, we observed that the expression of miR-125a was inversely correlated with HuR expression in several different breast carcinoma cell lines...
  72. Lu L, Wang S, Zheng L, Li X, Suswam E, Zhang X, et al. Amyotrophic lateral sclerosis-linked mutant SOD1 sequesters Hu antigen R (HuR) and TIA-1-related protein (TIAR): implications for impaired post-transcriptional regulation of vascular endothelial growth factor. J Biol Chem. 2009;284:33989-98 pubmed publisher
    ..Here, we show that the major RNA stabilizer, Hu Antigen R (HuR), and TIA-1-related protein (TIAR) colocalize with mutant SOD1 in mouse spinal cord extracts and cultured ..
  73. Scott G, Marx C, Berger C, Saunders L, Verdin E, Schafer S, et al. Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6. Mol Cancer Res. 2008;6:1250-8 pubmed publisher
    ..Using ERBB2-overexpressing human breast cancer cells (SKBR3), the mRNA stability factor HuR was shown to support ERBB2 transcript integrity, bind and endogenously associate with a conserved U-rich element ..
  74. Ghisolfi L, Calastretti A, Franzi S, Canti G, Donnini M, Capaccioli S, et al. B cell lymphoma (Bcl)-2 protein is the major determinant in bcl-2 adenine-uridine-rich element turnover overcoming HuR activity. J Biol Chem. 2009;284:20946-55 pubmed publisher
    ..In the context of an AUBPs silencing approach, HuR knockdown reduced the expression of endogenous bcl-2, whereas unexpectedly, a bcl-2 ARE-reporter transcript ..
  75. Al Ahmadi W, Al Haj L, Al Mohanna F, Silverman R, Khabar K. RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth. Oncogene. 2009;28:1782-91 pubmed publisher
    ..Here, we show that overexpression of RNase L decreases cellular growth and downmodulates the RNA-binding protein, HuR, a regulator of cell-cycle progression and tumorigenesis...
  76. Brennan C, Gallouzi I, Steitz J. Protein ligands to HuR modulate its interaction with target mRNAs in vivo. J Cell Biol. 2000;151:1-14 pubmed
    ..b>HuR, a ubiquitously expressed member of the ELAV (embryonic lethal abnormal vision) family of RNA binding proteins, ..
  77. Wang W, Furneaux H, Cheng H, Caldwell M, Hutter D, Liu Y, et al. HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol. 2000;20:760-9 pubmed
    ..The ubiquitous Elav-type RNA-binding protein HuR was identified within the p21 mRNA-protein complexes, as antibodies recognizing HuR supershifted these complexes ..
  78. von Roretz C, Gallouzi I. Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). J Biol Chem. 2010;285:16806-13 pubmed publisher
    The RNA-binding protein human antigen R (HuR) has been implicated in apoptosis in multiple ways...
  79. Vazquez Chantada M, Fernandez Ramos D, Embade N, Martínez López N, Varela Rey M, Woodhoo A, et al. HuR/methyl-HuR and AUF1 regulate the MAT expressed during liver proliferation, differentiation, and carcinogenesis. Gastroenterology. 2010;138:1943-53 pubmed publisher
    ..and MAT2A revealed putative binding sites for the RNA-binding proteins AU-rich RNA binding factor 1 (AUF1) and HuR, respectively...
  80. Filippova N, Yang X, King P, Nabors L. Phosphoregulation of the RNA-binding protein Hu antigen R (HuR) by Cdk5 affects centrosome function. J Biol Chem. 2012;287:32277-87 pubmed publisher
    b>Hu antigen R (HuR) is an mRNA-binding protein belonging to the ELAV family. It is highly expressed in cancer and involved in cell survival and proliferation...
  81. Izquierdo J. Hu antigen R (HuR) functions as an alternative pre-mRNA splicing regulator of Fas apoptosis-promoting receptor on exon definition. J Biol Chem. 2008;283:19077-84 pubmed publisher
    ..I report that antiapoptotic regulator Hu antigen R (HuR, ELAVL1), a member of the embryonic lethal, abnormal vision, Drosophila-like (ELAVL) family, promotes Fas ..
  82. Kim H, Abdelmohsen K, Lal A, Pullmann R, Yang X, Galban S, et al. Nuclear HuR accumulation through phosphorylation by Cdk1. Genes Dev. 2008;22:1804-15 pubmed publisher
    A predominantly nuclear RNA-binding protein, HuR translocates to the cytoplasm in response to stress and proliferative signals, where it stabilizes or modulates the translation of target mRNAs...
  83. Kawai T, Lal A, Yang X, Galban S, Mazan Mamczarz K, Gorospe M. Translational control of cytochrome c by RNA-binding proteins TIA-1 and HuR. Mol Cell Biol. 2006;26:3295-307 pubmed
    ..proteins that associate with its approximately 900-bp-long, adenine- and uridine-rich 3' untranslated region (UTR): HuR, which displayed affinity for several regions of the cytochrome c 3'UTR, and T-cell-restricted intracellular ..
  84. Xu Y, Di Marco S, Gallouzi I, Rola Pleszczynski M, Radzioch D. RNA-binding protein HuR is required for stabilization of SLC11A1 mRNA and SLC11A1 protein expression. Mol Cell Biol. 2005;25:8139-49 pubmed
    ..in human monocytes and HL-60 cells and then use HL-60 cells as a model to determine whether RNA-binding protein HuR is associated with the ARE and involved in SLC11A1 mRNA turnover...
  85. Kim G, Lim S, Kim Y. Expression of HuR, COX-2, and survivin in lung cancers; cytoplasmic HuR stabilizes cyclooxygenase-2 in squamous cell carcinomas. Mod Pathol. 2011;24:1336-47 pubmed publisher
    b>Hu antigen R (HuR) is a member of the human family of embryonic-lethal, abnormal vision-like proteins, which serves as an mRNA-binding protein...
  86. Casolaro V, Fang X, Tancowny B, Fan J, Wu F, Srikantan S, et al. Posttranscriptional regulation of IL-13 in T cells: role of the RNA-binding protein HuR. J Allergy Clin Immunol. 2008;121:853-9.e4 pubmed publisher
    ..We investigated IL-13 posttranscriptional regulation by HuR, a protein associating with adenylate-uridylate-rich elements in the 3' untranslated regions (UTRs) of mRNA, ..
  87. Denkert C, Weichert W, Winzer K, Müller B, Noske A, Niesporek S, et al. Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res. 2004;10:5580-6 pubmed
    The human ELAV (embryonic lethal abnormal vision)-like protein HuR stabilizes a certain group of cellular mRNAs that contain AU-rich elements in their 3'-untranslated region...
  88. Sakuma T, Nakagawa T, Ido K, Takeuchi H, Sato K, Kubota T. Expression of vascular endothelial growth factor-A and mRNA stability factor HuR in human meningiomas. J Neurooncol. 2008;88:143-55 pubmed publisher
    We studied the expression of vascular endothelial growth factor-A (VEGF-A) and mRNA stability factor HuR in 40 supratentorial meningiomas using RT-PCR, ELISA and immunohistochemistry, and analyzed their associations with the ..
  89. Lopez de Silanes I, Zhan M, Lal A, Yang X, Gorospe M. Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci U S A. 2004;101:2987-92 pubmed
    b>HuR, a protein that binds to specific mRNA subsets, is increasingly recognized as a pivotal posttranscriptional regulator of gene expression...
  90. Ma W, Cheng S, Campbell C, Wright A, Furneaux H. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein. J Biol Chem. 1996;271:8144-51 pubmed
    ..We have identified and cloned a fourth member of this family (HuR) that is expressed in a wide variety of cell types...
  91. Raspaglio G, De Maria I, Filippetti F, Martinelli E, Zannoni G, Prislei S, et al. HuR regulates beta-tubulin isotype expression in ovarian cancer. Cancer Res. 2010;70:5891-900 pubmed publisher
    ..In silico analysis of TUBB3 mRNA sequence predicted a putative binding site for the RNA-binding protein Hu antigen (HuR) in the 3' flanking untranslated region...