HUEL

Summary

Gene Symbol: HUEL
Description: solute carrier family 30 member 9
Alias: BILAPES, C4orf1, GAC63, HUEL, ZNT9, zinc transporter 9, GRIP1-dependent nuclear receptor coactivator, expressed in human embryonic lung, human embryonic lung protein, solute carrier family 30 (zinc transporter), member 9, znT-9
Species: human
Products:     HUEL

Top Publications

  1. Wahono N, Ford D, Wakeling L, Valentine R. The presence and response to Zn of ZnT family mRNAs in human dental pulp. Metallomics. 2019;11:613-620 pubmed publisher
    ..ZnT1, ZnT5 and ZnT9 mRNAs were detected by RT-PCR in both the secretory odontoblast cells and human dental pulp...
  2. Vargas D, De Bastiani M, Zimmer E, Klamt F. Alzheimer's disease master regulators analysis: search for potential molecular targets and drug repositioning candidates. Alzheimers Res Ther. 2018;10:59 pubmed publisher
  3. Gartmann L, Wex T, Grüngreiff K, Reinhold D, Kalinski T, Malfertheiner P, et al. Expression of zinc transporters ZIP4, ZIP14 and ZnT9 in hepatic carcinogenesis-An immunohistochemical study. J Trace Elem Med Biol. 2018;49:35-42 pubmed publisher
    ..of this study is to assess the expression level of three zinc transporters in liver tissue and HCC: ZIP4, ZIP14 and ZnT9. The study is based on tissue samples obtained from 138 patients with histologically proven HCC...
  4. Wu X, Gao L, Zhou K, Li X, Lin X, Wan D, et al. Deposition and transport of trace mineral elements were affected by stocking density in fattening pigs. J Trace Elem Med Biol. 2018;50:566-571 pubmed publisher
    ..Stocking density also affected mRNA expression of trace mineral transporters in both the liver and intestinal mucosa of fattening pigs under the studied conditions. ..
  5. Generous A, Thorson M, Barcus J, Jacher J, Busch M, Sleister H. Identification of putative interactions between swine and human influenza A virus nucleoprotein and human host proteins. Virol J. 2014;11:228 pubmed publisher
    ..This study extends previous findings by suggesting a mechanism by which these host proteins associate with the IAV, i.e., physical interaction with NP. Furthermore, this study revealed novel host protein-NP interactions in yeast. ..
  6. Beaver L, Nkrumah Elie Y, Truong L, Barton C, Knecht A, Gonnerman G, et al. Adverse effects of parental zinc deficiency on metal homeostasis and embryonic development in a zebrafish model. J Nutr Biochem. 2017;43:78-87 pubmed publisher
    ..embryos had altered expression of genes that regulate metal homeostasis including several zinc transporters (ZnT8, ZnT9) and the metal-regulatory transcription factor 1 (MTF-1)...
  7. Engelken J, Espadas G, Mancuso F, Bonet N, Scherr A, Jímenez Álvarez V, et al. Signatures of Evolutionary Adaptation in Quantitative Trait Loci Influencing Trace Element Homeostasis in Liver. Mol Biol Evol. 2016;33:738-54 pubmed publisher
  8. Hennigar S, Kelley A, McClung J. Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review. Adv Nutr. 2016;7:735-46 pubmed publisher
    ..zinc transporter (ZnT)1 (SLC30A1), ZnT2 (SLC30A2), ZnT4 (SLC30A4), ZnT5 (SLC30A5), ZnT6 (SLC30A6), ZnT7 (SLC30A7), ZnT9 (SLC30A9), and/or metallothionein in various blood cells isolated from healthy adult men and women in response to ..
  9. Sim D, Yeo W, Chow V. The novel human HUEL (C4orf1) protein shares homology with the DNA-binding domain of the XPA DNA repair protein and displays nuclear translocation in a cell cycle-dependent manner. Int J Biochem Cell Biol. 2002;34:487-504 pubmed
    We have previously isolated and characterized a novel human gene HUEL (C4orf1) that is ubiquitously expressed in a wide range of human fetal, adult tissues and cancer cell lines...

More Information

Publications18

  1. Falcon Perez J, Dell Angelica E. Zinc transporter 2 (SLC30A2) can suppress the vesicular zinc defect of adaptor protein 3-depleted fibroblasts by promoting zinc accumulation in lysosomes. Exp Cell Res. 2007;313:1473-83 pubmed
  2. Sim D, Chow V. The novel human HUEL (C4orf1) gene maps to chromosome 4p12-p13 and encodes a nuclear protein containing the nuclear receptor interaction motif. Genomics. 1999;59:224-33 pubmed
    ..This gene was designated HUEL and given the symbol C4orf1 by the HUGO Nomenclature Committee...
  3. Bodiga V, Thokala S, Kovur S, Bodiga S. Zinc Dyshomeostasis in Cardiomyocytes after Acute Hypoxia/Reoxygenation. Biol Trace Elem Res. 2017;179:117-129 pubmed publisher
    ..Neither hypoxia nor reoxygenation altered the levels of ZnT9. Increased intracellular zinc at the end of hypoxia is related to enhanced expression of ZIPs, whereas decreased ..
  4. Hardt S, Heidler J, Albuquerque B, Valek L, Altmann C, Wilken Schmitz A, et al. Loss of synaptic zinc transport in progranulin deficient mice may contribute to progranulin-associated psychopathology and chronic pain. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2727-2745 pubmed publisher
    ..In particular, progranulin deficiency was associated with a deficiency of nuclear and synaptic zinc transporters (ZnT9/Slc30a9; ZnT3/Slc30a3) with low plasma zinc...
  5. Cheng X, Xu C, DeGiorgio M. Fast and robust detection of ancestral selective sweeps. Mol Ecol. 2017;: pubmed publisher
    ..Finally, we provide open-source software, CalcABS, which can perform genomic scans of ancestral sweeps with ABS from population allele frequency data. This article is protected by copyright. All rights reserved...
  6. Chen Y, Kim J, Stallcup M. GAC63, a GRIP1-dependent nuclear receptor coactivator. Mol Cell Biol. 2005;25:5965-72 pubmed
    ..In this study, we identified a novel NR coactivator, GAC63, which binds to the N-terminal region of p160 coactivators as well as the ligand binding domains of some NRs...
  7. Kang X, Chen R, Zhang J, Li G, Dai P, Chen C, et al. Expression Profile Analysis of Zinc Transporters (ZIP4, ZIP9, ZIP11, ZnT9) in Gliomas and their Correlation with IDH1 Mutation Status. Asian Pac J Cancer Prev. 2015;16:3355-60 pubmed
    ..IDH1 mutation status and mRNA expression of four zinc transporters (ZIP4, ZIP9, ZIP11, and ZnT9) were determined by subjecting a panel of 74 glioma tissue samples to quantitative real-time PCR and pyrosequencing...
  8. Perez Y, Shorer Z, Liani Leibson K, Chabosseau P, Kadir R, Volodarsky M, et al. SLC30A9 mutation affecting intracellular zinc homeostasis causes a novel cerebro-renal syndrome. Brain. 2017;140:928-939 pubmed publisher
  9. Overbeck S, Uciechowski P, Ackland M, Ford D, Rink L. Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9. J Leukoc Biol. 2008;83:368-80 pubmed
    ..These data provide insight into the regulation of intracellular zinc homeostasis in cells of the immune system and may explain the variable effects of zinc deficiency on different leukocyte subsets. ..