HTR2A

Summary

Gene Symbol: HTR2A
Description: 5-hydroxytryptamine receptor 2A
Alias: 5-HT2A, HTR2, 5-hydroxytryptamine receptor 2A, 5-HT2 receptor, 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled, serotonin 5-HT-2A receptor
Species: human
Products:     HTR2A

Top Publications

  1. Beretta L, Cossu M, Marchini M, Cappiello F, Artoni A, Motta G, et al. A polymorphism in the human serotonin 5-HT2A receptor gene may protect against systemic sclerosis by reducing platelet aggregation. Arthritis Res Ther. 2008;10:R103 pubmed publisher
    ..003 after correction for baseline adenosine diphosphate-induced aggregation values). The His452Tyr substitution may influence susceptibility to systemic sclerosis by altering platelet aggregation in response to serotonin. ..
  2. Hamdani N, Bonnière M, Ades J, Hamon M, Boni C, Gorwood P. Negative symptoms of schizophrenia could explain discrepant data on the association between the 5-HT2A receptor gene and response to antipsychotics. Neurosci Lett. 2005;377:69-74 pubmed
    ..This data indicate that negative symptoms are worth being systematically assessed in pharmacogenetic studies aimed at analysing candidate genes in schizophrenia. ..
  3. Rybakowski F, Slopien A, Dmitrzak Weglarz M, Czerski P, Rajewski A, Hauser J. The 5-HT2A -1438 A/G and 5-HTTLPR polymorphisms and personality dimensions in adolescent anorexia nervosa: association study. Neuropsychobiology. 2006;53:33-9 pubmed
    ..Our results may suggest that the A allele of the -1438 A/G polymorphism confers some genetic risk for adolescent AN patients, especially in those with personality traits, which are typical of the restrictive-type AN. ..
  4. Mutlu N, Erdal M, Herken H, Oz G, Bayazit Y. T102C polymorphism of the 5-HT2A receptor gene may be associated with temporomandibular dysfunction. Oral Dis. 2004;10:349-52 pubmed
    ..The overrepresentation of the C/C variant of 5-HT2A receptor gene in temporomandibular dysfunction suggests a possible role of the serotonergic system in this disease, particularly at the receptor level. ..
  5. Tochigi M, Umekage T, Kato C, Marui T, Otowa T, Hibino H, et al. Serotonin 2A receptor gene polymorphism and personality traits: no evidence for significant association. Psychiatr Genet. 2005;15:67-9 pubmed
    ..Thus, the present study provided no evidence for statistically significant associations between the 5-HT2A polymorphisms and the personality traits. ..
  6. Erritzoe D, Holst K, Frokjaer V, Licht C, Kalbitzer J, Nielsen F, et al. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. J Neurosci. 2010;30:3391-7 pubmed publisher
    ..That is, the observed association between the 5-HT(2A) receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand. ..
  7. Parsons M, D Souza U, Arranz M, Kerwin R, Makoff A. The -1438A/G polymorphism in the 5-hydroxytryptamine type 2A receptor gene affects promoter activity. Biol Psychiatry. 2004;56:406-10 pubmed
    ..SNP) lies just upstream of two alternative promoters for the 5-hydroxytryptamine type 2A (5-HT2A) receptor gene (HTR2A) and is in strong linkage disequilibrium with the 102T/C SNP...
  8. Knauer C, Campbell J, Chio C, Fitzgerald L. Pharmacological characterization of mitogen-activated protein kinase activation by recombinant human 5-HT2C, 5-HT2A, and 5-HT2B receptors. Naunyn Schmiedebergs Arch Pharmacol. 2009;379:461-71 pubmed publisher
    ..This profile differs from reports of "agonist-directed trafficking of receptor stimulus" between PI/Ca(2+) and AA pathways activated by 5-HT(2) receptors. ..
  9. Kring S, Werge T, Holst C, Toubro S, Astrup A, Hansen T, et al. Polymorphisms of serotonin receptor 2A and 2C genes and COMT in relation to obesity and type 2 diabetes. PLoS ONE. 2009;4:e6696 pubmed publisher
    ..01). The findings lend further support to the involvement of serotonin, noradrenaline and dopamine pathways on obesity and glucose homeostasis, in particular when combined genotype associations are explored. ..

More Information

Publications69

  1. Shelton R, Sanders Bush E, Manier D, Lewis D. Elevated 5-HT 2A receptors in postmortem prefrontal cortex in major depression is associated with reduced activity of protein kinase A. Neuroscience. 2009;158:1406-15 pubmed publisher
    ..The correlation of 5-HT(2A) receptor levels with PKA activity in the depressed group suggests that abnormalities of 5-HT(2A) receptor abundance may depend on receptor uncoupling and heterologous regulation by PKA. ..
  2. Falkenberg V, Gurbaxani B, Unger E, Rajeevan M. Functional genomics of serotonin receptor 2A (HTR2A): interaction of polymorphism, methylation, expression and disease association. Neuromolecular Med. 2011;13:66-76 pubmed publisher
    ..of a promoter polymorphism, -1438G/A (rs6311), in one of the major genes of this system (serotonin receptor 2A, HTR2A) remains poorly understood in the context of epigenetic factors, transcription factors and endocrine influences...
  3. Gizer I, Ficks C, Waldman I. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet. 2009;126:51-90 pubmed publisher
    ..g., ADHD subtype diagnoses, gender, exposure to environmental risk factors). We conclude with a discussion of these findings in relation to emerging themes relevant to future studies of the genetics of ADHD. ..
  4. Ertugrul A, Kennedy J, Masellis M, Basile V, Jayathilake K, Meltzer H. No association of the T102C polymorphism of the serotonin 2A receptor gene (HTR2A) with suicidality in schizophrenia. Schizophr Res. 2004;69:301-5 pubmed
    ..role of serotonin (5-HT) in the pathogenesis of suicidal behavior is provided by a recent report that the 5-HT2A (HTR2A) T102C polymorphism was associated with suicidality in patients with major depression...
  5. Braden M, Nichols D. Assessment of the roles of serines 5.43(239) and 5.46(242) for binding and potency of agonist ligands at the human serotonin 5-HT2A receptor. Mol Pharmacol. 2007;72:1200-9 pubmed
    ..50, a strong interaction with Ser5.43(239) may be more effective in straightening the kink in helix 5, a feature that is possibly common to all type A GPCRs that have polar residues at position 5.43. ..
  6. Portnova G, Sysoeva O, Maliuchenko N, Timofeeva M, Kulikova M, Tonevitskii A, et al. [Genetic basis of time perception in athletes]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2007;57:450-60 pubmed
    ..The current study reveals that these physiological mechanisms have different molecular-neurochemical basis that helps to overcome the gap between the investigation on systemic and molecular levels. ..
  7. Saiz P, García Portilla M, Arango C, Morales B, Alvarez V, Coto E, et al. Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:741-5 pubmed
    ..Our findings support a possible synergistic effect of genetic factors influencing serotonergic neurotransmission on susceptibility to schizophrenia. ..
  8. Dijkstra J, Lindenberg S, Zijlstra L, Bouma E, Veenstra R. The secret ingredient for social success of young males: a functional polymorphism in the 5HT2A serotonin receptor gene. PLoS ONE. 2013;8:e54821 pubmed publisher
    ..This seems to be an "enhancer" effect of the G-allele whereby popularity relevant characteristics are made more noticeable. There is no "popularity gene", as the G-allele by itself had no effect on popularity. ..
  9. Zalsman G, Patya M, Frisch A, Ofek H, Schapir L, Blum I, et al. Association of polymorphisms of the serotonergic pathways with clinical traits of impulsive-aggression and suicidality in adolescents: a multi-center study. World J Biol Psychiatry. 2011;12:33-41 pubmed publisher
    ..This study evaluated association between common polymorphisms in the serotonergic and adrenergic candidate genes (HTR2A, 5HTTLPR, and MAOA) and suicidality, psychopathology and aggression in adolescents...
  10. Herbeth B, Aubry E, Fumeron F, Aubert R, Cailotto F, Siest G, et al. Polymorphism of the 5-HT2A receptor gene and food intakes in children and adolescents: the Stanislas Family Study. Am J Clin Nutr. 2005;82:467-70 pubmed
    ..The 5-HT2A gene polymorphism in the promoter region is associated with energy and fat intakes in young people. This could be explained by the role of the serotonergic system as a determinant of food intakes and eating behavior. ..
  11. Quednow B, Kuhn K, Mossner R, Schwab S, Schuhmacher A, Maier W, et al. Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms. Biol Psychiatry. 2008;64:434-7 pubmed publisher
    ..Our findings suggest that PPI and habituation are modulated by 5-HT(2A)R A-1438G and T102C genotype in schizophrenia. Consequently, alterations within brain 5-HT(2A)Rs may contribute to the PPI deficits in schizophrenia. ..
  12. Yoon H, Kim Y. Association between serotonin-related gene polymorphisms and suicidal behavior in depressive patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:1293-7 pubmed publisher
    ..Our results were in line with most previous studies. More work is needed to replicate these findings. Our future studies aim at identifying other genetic associations. ..
  13. Garbett K, Gal Chis R, Gaszner G, Lewis D, Mirnics K. Transcriptome alterations in the prefrontal cortex of subjects with schizophrenia who committed suicide. Neuropsychopharmacol Hung. 2008;10:9-14 pubmed
    ..Furthermore, the observed gene expression signature contains a prefrontal cortical downregulation of the HTR2A serotonin receptor transcript, strengthening previously reported genetic susceptibility reports...
  14. Ribases M, Ramos Quiroga J, Hervas A, Bosch R, Bielsa A, Gastaminza X, et al. Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB. Mol Psychiatry. 2009;14:71-85 pubmed
  15. Assal F, Alarcon M, Solomon E, Masterman D, Geschwind D, Cummings J. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Arch Neurol. 2004;61:1249-53 pubmed
    ..Absence of other positive associations may be due to the relatively small sample size and/or potentially small effect size of the polymorphisms and requires further study. ..
  16. Khait V, Huang Y, Zalsman G, Oquendo M, Brent D, HARKAVY FRIEDMAN J, et al. Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects. Neuropsychopharmacology. 2005;30:166-72 pubmed
    ..The TT genotype appears associated with higher platelet 5-HT2A Bmax in the healthy population, but this genotypic effect appears absent in mood disorders and unrelated to psychopathology. ..
  17. Sakai K, Takada T, Nakayama H, Kubota Y, Nakamata M, Satoh M, et al. Serotonin-2A and 2C receptor gene polymorphisms in Japanese patients with obstructive sleep apnea. Intern Med. 2005;44:928-33 pubmed
    ..Polymorphisms in the 5-HT 2A receptor gene (HTR2A) and 5-HT 2C receptor gene (HTR2C) are associated with various diseases...
  18. Wingen M, Kuypers K, Ramaekers J. Selective verbal and spatial memory impairment after 5-HT1A and 5-HT2A receptor blockade in healthy volunteers pre-treated with an SSRI. J Psychopharmacol. 2007;21:477-85 pubmed
  19. Filippini N, Scassellati C, Boccardi M, Pievani M, Testa C, Bocchio Chiavetto L, et al. Influence of serotonin receptor 2A His452Tyr polymorphism on brain temporal structures: a volumetric MR study. Eur J Hum Genet. 2006;14:443-9 pubmed
    ..These findings should be considered preliminary and future replication is needed. ..
  20. McMahon F, Buervenich S, Charney D, Lipsky R, Rush A, Wilson A, et al. Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet. 2006;78:804-814 pubmed publisher
    ..We detected significant and reproducible association between treatment outcome and a marker in HTR2A (P range 1 x 10(-6) to 3.7 x 10(-5) in the total sample)...
  21. Bayazit Y, Yilmaz M, Ciftci T, Erdal E, Kokturk O, Gokdogan T, et al. Association of the -1438G/A polymorphism of the 5-HT2A receptor gene with obstructive sleep apnea syndrome. ORL J Otorhinolaryngol Relat Spec. 2006;68:123-8 pubmed
    ..However, the -1438G/A polymorphism is associated with OSAS occurrence, especially in male patients. This polymorphism may also be associated with different OSAS incidences of both genders. ..
  22. Vaquero Lorenzo C, Baca Garcia E, Diaz Hernandez M, Perez Rodriguez M, Fernandez Navarro P, Giner L, et al. Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:645-9 pubmed publisher
    ..The C allele of the T102C polymorphism of the 5-HT2A receptor gene may be associated with biological susceptibility for suicidal behavior or psychiatric conditions. ..
  23. Etain B, Rousseva A, Roy I, Henry C, Malafosse A, Buresi C, et al. Lack of association between 5HT2A receptor gene haplotype, bipolar disorder and its clinical subtypes in a West European sample. Am J Med Genet B Neuropsychiatr Genet. 2004;129B:29-33 pubmed
    ..Our study suggests that the 5HT2AR gene is unlikely to be involved in genetic susceptibility to BPAD but should be further investigated in a pharmacogenetic study. ..
  24. Oades R, Lasky Su J, Christiansen H, Faraone S, Sonuga Barke E, Banaschewski T, et al. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Behav Brain Funct. 2008;4:48 pubmed publisher
    ..Nominal significance was shown for 12 SNPs from BDNF, DRD1, HTR1E, HTR2A, HTR3B, DAT1/SLC6A3, and TPH2 genes replicating reported associations with ADHD...
  25. Maginnis M, Haley S, Gee G, Atwood W. Role of N-linked glycosylation of the 5-HT2A receptor in JC virus infection. J Virol. 2010;84:9677-84 pubmed publisher
    ..These data affirm the importance of 5-HT(2A)R as a JCV receptor and demonstrate that the sialic acid component of the receptor is not directly linked to 5-HT(2A)R...
  26. Reuter M, Kirsch P, Hennig J. Inferring candidate genes for attention deficit hyperactivity disorder (ADHD) assessed by the World Health Organization Adult ADHD Self-Report Scale (ASRS). J Neural Transm (Vienna). 2006;113:929-38 pubmed
    ..52, p = 0.020) and the total ASRS scale (F(1, 201) = 4.21, p = 0.042) with highest scores in carriers of the TT genotype. The data provide evidence for the structural as well as for the external validity of the ASRS. ..
  27. Yin G, Ye J, Han D, Zhang Y, Zeng W, Liang C. Association of the 5-HT2A receptor gene polymorphisms with obstructive sleep apnea hypopnea syndrome in Chinese Han population. Acta Otolaryngol. 2012;132:203-9 pubmed publisher
    ..001, p = 0.005, respectively). In the patients, the A/A and G/A genotypes were over-represented in the subgroups with lowest nocturnal SaO(2) (LSaO(2)) ?75% and LSaO(2) >75%, respectively (p = 0.006). ..
  28. Ni X, Bismil R, Chan K, Sicard T, Bulgin N, McMain S, et al. Serotonin 2A receptor gene is associated with personality traits, but not to disorder, in patients with borderline personality disorder. Neurosci Lett. 2006;408:214-9 pubmed
    ..The serotonin 2A receptor gene (HTR2A) is considered a candidate gene for BPD because multiple lines of evidence suggest that it plays an important role ..
  29. de Carvalho T, Suman M, Molina F, Piatto V, Maniglia J. Relationship of obstructive sleep apnea syndrome with the 5-HT2A receptor gene in Brazilian patients. Sleep Breath. 2013;17:57-62 pubmed publisher
    ..The aim of this study was to determine the prevalence of the 102T-C and -1438G-A polymorphisms in the 5-HTR2A gene in Brazilian patients with and without OSAS...
  30. Smith A, Dimulescu I, Falkenberg V, Narasimhan S, Heim C, Vernon S, et al. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology. 2008;33:188-97 pubmed
    ..A total of 77 polymorphisms in genes related to serotonin synthesis (TPH2), signaling (HTR1A, HTR1E, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, and HTR7), transport (SLC6A4), and catabolism (MAOA) were examined ..
  31. Wrzosek M, Łukaszkiewicz J, Wrzosek M, Serafin P, Jakubczyk A, Klimkiewicz A, et al. Association of polymorphisms in HTR2A, HTR1A and TPH2 genes with suicide attempts in alcohol dependence: a preliminary report. Psychiatry Res. 2011;190:149-51 pubmed publisher
    We investigated a relationship between selected polymorphisms: rs6313 in HTR2A, rs6295 in HTR1A and rs1386494 in TPH2, and suicidal behaviour in 150 alcohol-dependent patients...
  32. Hurlemann R, Matusch A, Kuhn K, Berning J, Elmenhorst D, Winz O, et al. 5-HT2A receptor density is decreased in the at-risk mental state. Psychopharmacology (Berl). 2008;195:579-90 pubmed
    ..Five single nucleotide polymorphisms (SNPs) in the 5-HT(2A)R-encoding gene (HTR2A; 13q14-21) were genotyped to control for a potential bias in BP(1)' due to between-group differences in genotype ..
  33. Ben Efraim Y, Wasserman D, Wasserman J, Sokolowski M. Family-based study of HTR2A in suicide attempts: observed gene, gene × environment and parent-of-origin associations. Mol Psychiatry. 2013;18:758-66 pubmed publisher
    ..by serotonergic system alterations, specific associations with genetic variation in the serotonin 2A receptor (HTR2A) gene have been inconsistent...
  34. Denys D, Van Nieuwerburgh F, Deforce D, Westenberg H. Prediction of response to paroxetine and venlafaxine by serotonin-related genes in obsessive-compulsive disorder in a randomized, double-blind trial. J Clin Psychiatry. 2007;68:747-53 pubmed
  35. Heiser P, Dempfle A, Friedel S, Konrad K, Hinney A, Kiefl H, et al. Family-based association study of serotonergic candidate genes and attention-deficit/hyperactivity disorder in a German sample. J Neural Transm (Vienna). 2007;114:513-21 pubmed
    ..in three genes (serotonin transporter (5-HTT), serotonin receptor 1B (5-HTR1B) and serotonin receptor 2A (5-HTR2A)), which have previously been shown to be associated with ADHD...
  36. Moreno J, Muguruza C, Umali A, Mortillo S, Holloway T, Pilar Cuéllar F, et al. Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function. J Biol Chem. 2012;287:44301-19 pubmed publisher
    ..Together, these findings provide structural evidence for the unique behavioral function of a GPCR heteromer. ..
  37. Gu L, Long J, Yan Y, Chen Q, Pan R, Xie X, et al. HTR2A-1438A/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: a meta-analysis. J Neurosci Res. 2013;91:623-33 pubmed publisher
    ..a strong genetic component, and we conducted this study to investigate whether the -1438A/G polymorphism of the HTR2A gene was associated with susceptibility to schizophrenia (SZ), bipolar disorder (BD), and major depressive ..
  38. Cao J, Liu X, Han S, Zhang C, Liu Z, Li D. Association of the HTR2A gene with alcohol and heroin abuse. Hum Genet. 2014;133:357-65 pubmed publisher
    ..of rs6313 (102T/C at exon 1) and rs6311 (-1438A/G) on the 5-hydroxytryptamine (serotonin) 2A receptor gene (HTR2A or 5-HT2A) were reported for alcohol and drug abuse; however, other association studies failed to produce ..
  39. Seddighzadeh M, Korotkova M, Kallberg H, Ding B, Daha N, Kurreeman F, et al. Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis. Eur J Hum Genet. 2010;18:821-6 pubmed publisher
    ..Recently, we found that HTR2A, a member of the serotonin receptor family, is associated with rheumatoid arthritis (RA)...
  40. Rubin D, Althoff R, Ehli E, Davies G, Rettew D, Crehan E, et al. Candidate gene associations with withdrawn behavior. J Child Psychol Psychiatry. 2013;54:1337-45 pubmed publisher
    ..Withdrawn behavior was highly associated with polymorphism rs6314 of the serotonin receptor 2A (HTR2A) [p = .009, estimate = 0.310 (bootstrap 95% CI 0.155-0.448), bootstrap p = ...
  41. Smith R, Papp A, Webb A, Ruble C, Munsie L, Nisenbaum L, et al. Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex. Biol Psychiatry. 2013;73:546-54 pubmed publisher
    The 5-hydroxytryptamine 2A receptor, encoded by HTR2A, is a major postsynaptic target for serotonin in the human brain and a therapeutic drug target...
  42. Wagner M, Schuhmacher A, Schwab S, Zobel A, Maier W. The His452Tyr variant of the gene encoding the 5-HT2A receptor is specifically associated with consolidation of episodic memory in humans. Int J Neuropsychopharmacol. 2008;11:1163-7 pubmed publisher
    ..Results suggest a possible role of 5-HT2A receptors in memory consolidation. Serotonergic drugs may have the potential to improve memory. ..
  43. Gonzalez Maeso J, ANG R, Yuen T, Chan P, Weisstaub N, Lopez Gimenez J, et al. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature. 2008;452:93-7 pubmed publisher
    ..These regulatory changes indicate that the 2AR-mGluR2 complex may be involved in the altered cortical processes of schizophrenia, and this complex is therefore a promising new target for the treatment of psychosis. ..
  44. Nomura M, Nomura Y. Psychological, neuroimaging, and biochemical studies on functional association between impulsive behavior and the 5-HT2A receptor gene polymorphism in humans. Ann N Y Acad Sci. 2006;1086:134-43 pubmed
    ..This hypothesis was evaluated by using a behavioral task measure that could directly reveal impulsive behavioral traits in humans. ..
  45. Polina E, Contini V, Hutz M, Bau C. The serotonin 2A receptor gene in alcohol dependence and tobacco smoking. Drug Alcohol Depend. 2009;101:128-31 pubmed publisher
    ..Variations in the serotonergic system may influence some aspects of smoking. The serotonin receptor gene HTR2A has been a candidate gene with some evidence for association with alcohol and nicotine dependencies...
  46. Papassotiropoulos A, Henke K, Aerni A, Coluccia D, Garcia E, Wollmer M, et al. Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory. Neuroreport. 2005;16:839-42 pubmed
    ..We conclude that age strongly modulates the effect of the 5-HT2a receptor polymorphism at residue 452 on episodic memory. ..
  47. Guimarães A, Zeni C, Polanczyk G, Genro J, Roman T, Rohde L, et al. Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:69-73 pubmed
    ..of the serotonin transporter (SLC6A4) and two polymorphisms (-1438 A > G and His452Tyr) in the serotonin 5-HTR2A receptor gene using family based association analyses in a sample of 243 Brazilian ADHD children and adolescents ..
  48. Sigurdh J, Allard P, Spigset O, Hägglöf B. Platelet serotonin transporter and 5-HT2A receptor binding in adolescents with eating disorders. Int J Neurosci. 2013;123:333-8 pubmed publisher
  49. Cho I, Yoo H, Park M, Lee Y, Kim S. Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios. Brain Res. 2007;1139:34-41 pubmed
    ..Promoter region polymorphisms (5-HTTLPR) of the serotonin transporter gene (SLC6A4) and the 5-HT2A receptor gene (HTR2A) have been studied as potential candidate genes in autism spectrum disorder (ASD)...
  50. Zhang J, Shen Y, He G, Li X, Meng J, Guo S, et al. Lack of association between three serotonin genes and suicidal behavior in Chinese psychiatric patients. Prog Neuropsychopharmacol Biol Psychiatry. 2008;32:467-71 pubmed
    ..to be involved in suicidal behavior and there is evidence of biological abnormalities of two serotonin receptors (HTR2A, HTR2C) and one serotonin transporter (5HTT) in suicide victims...
  51. Tander B, Gunes S, Boke O, Alayli G, Kara N, Bagci H, et al. Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. Rheumatol Int. 2008;28:685-91 pubmed publisher
    ..05). Our results suggest that the investigated polymorphisms seem not to be the susceptibility factors in etiology of FMS. ..
  52. Wilkie M, Smith G, Day R, Matthews K, Smith D, Blackwood D, et al. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy. Pharmacogenomics J. 2009;9:61-70 pubmed publisher
    ..In this study, nine polymorphisms in four serotonin receptor genes (HTR1B, HTR2A, HTR5A and HTR6) and the serotonin transporter gene (SLC6A4) were analysed to investigate their influence on ..
  53. Yoon H, Kim Y. TPH2 -703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:403-9 pubmed publisher
    ..In this study, we aimed to investigate the association of serotonin 2A receptor gene -1438A/G SNP (HTR2A -1438A/G), tryptophan hydroxylase 2 gene -703G/T SNP (TPH2 -703G/T) and serotonin 1A receptor C-1019G (HTR1A C-..
  54. Sorli J, Frances F, Gonzalez J, Guillen M, Portoles O, Sabater A, et al. Impact of the -1438G>a polymorphism in the serotonin 2A receptor gene on anthropometric profile and obesity risk: a case-control study in a Spanish Mediterranean population. Appetite. 2008;50:260-5 pubmed
    ..The polymorphism -1438G>A in the serotonin 2A receptor or 5-hydroxytriptamine (5-HT) type 2A receptor (5-HTR2A) gene has been associated with alterations in food intake such as anorexia and bulimia...
  55. Correa H, De Marco L, Boson W, Nicolato R, Teixeira A, Campo V, et al. Association study of T102C 5-HT(2A) polymorphism in schizophrenic patients: diagnosis, psychopathology, and suicidal behavior. Dialogues Clin Neurosci. 2007;9:97-101 pubmed
    ..These results suggest that the 5-HT(2A) gene polymorphism (102T/C) is not involved in genetic susceptibility to suicidal behavior, but further studies in a larger sample are needed. ..
  56. Jakubczyk A, Wrzosek M, Lukaszkiewicz J, Sadowska Mazuryk J, Matsumoto H, Sliwerska E, et al. The CC genotype in HTR2A T102C polymorphism is associated with behavioral impulsivity in alcohol-dependent patients. J Psychiatr Res. 2012;46:44-9 pubmed publisher
    ..Blood was collected and analyzed for the T102C (rs6313) polymorphism in the serotonin type 2A receptor gene (HTR2A)...
  57. Golimbet V, Lavrushina O, Kaleda V, Abramova L, Lezheiko T. Supportive evidence for the association between the T102C 5-HTR2A gene polymorphism and schizophrenia: a large-scale case-control and family-based study. Eur Psychiatry. 2007;22:167-70 pubmed
    Serotonin type 2A receptors (5-HTR2A) have long been implicated in schizophrenia pathology...
  58. Abdolmaleky H, Yaqubi S, Papageorgis P, Lambert A, Ozturk S, Sivaraman V, et al. Epigenetic dysregulation of HTR2A in the brain of patients with schizophrenia and bipolar disorder. Schizophr Res. 2011;129:183-90 pubmed publisher
    b>HTR2A gene has been the subject of numerous studies in psychiatric genetics because LSD, which resembles serotonin causes psychosis and atypical antipsychotic drugs target the HTR2A receptor...
  59. Saiz P, Garcia Portilla M, Paredes B, Arango C, Morales B, Alvarez V, et al. Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts. Psychiatr Genet. 2008;18:213-8 pubmed publisher
    ..The haplotype analysis showed no association between suicide attempt and haplotype distribution [likelihood ratio test (5)=4.40, P=0.493]. Our findings suggest that the -1438A allele may predispose for nonimpulsive suicidal behavior. ..
  60. Blasi G, De Virgilio C, Papazacharias A, Taurisano P, Gelao B, Fazio L, et al. Converging evidence for the association of functional genetic variation in the serotonin receptor 2a gene with prefrontal function and olanzapine treatment. JAMA Psychiatry. 2013;70:921-30 pubmed publisher
    ..Furthermore, newer antipsychotic drugs target 5-HT2AR. A single-nucleotide polymorphism in the 5-HT2AR gene (HTR2A rs6314, C>T; OMIM 182135) has been weakly associated with differential 5-HT2AR signaling and with physiologic ..