Gene Symbol: HTR1E
Description: 5-hydroxytryptamine receptor 1E
Alias: 5-HT1E, 5-hydroxytryptamine receptor 1E, 5-HT-1E, 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled, S31, serotonin receptor 1E
Species: human
Products:     HTR1E

Top Publications

  1. Suárez Trujillo A, Arguello A, Rivero M, Capote J, Castro N. Short communication: Differences in distribution of serotonin receptor subtypes in the mammary gland of sheep, goats, and cows during lactation and involution. J Dairy Sci. 2019;102:2703-2707 pubmed publisher
    ..Additionally, 5-HTR1E was present in cow endothelium...
  2. Sener E, Taheri S, Sahin M, Bayramov K, Marasli M, Zararsiz G, et al. Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders. J Mol Neurosci. 2019;67:89-96 pubmed publisher
    ..Gene expression also differed according to gender. Alterations in the mRNA expression patterns of the HTR1E, OPRL1, OPRM1, TACR1, PRKG1, SCN9A and DRD4 genes provide further evidence for a relevant effect of the respective ..
  3. Engwerda A, Frentz B, den Ouden A, Flapper B, Swertz M, Gerkes E, et al. The phenotypic spectrum of proximal 6q deletions based on a large cohort derived from social media and literature reports. Eur J Hum Genet. 2018;26:1478-1489 pubmed publisher
    ..known or assumed to be related to developmental delay and/or autism (BAI3, RIMS1, KCNQ5, HTR1B, PHIP, SYNCRIP, HTR1E, ZNF292, AKIRIN2 and EPHA7)...
  4. Hou Y, Xiong P, Gu X, Huang X, Wang M, Wu J. Association of Serotonin Receptors with Attention Deficit Hyperactivity Disorder: A Systematic Review and Meta-analysis. Curr Med Sci. 2018;38:538-551 pubmed publisher
    ..we also carried on a casecontrol study to explore the relevance between potential candidate genes 5-HTR1A, 5-HTR1E, 5-HTR3A and ADHD. The results indicated that 5-HTR1A rs6295 genotype (CC+CG vs. GG OR=2.00, 95% CI: 1.23-3...
  5. Sourbron J, Schneider H, Kecskés A, Liu Y, Buening E, Lagae L, et al. Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model. ACS Chem Neurosci. 2016;7:588-98 pubmed publisher
    ..Modulating certain serotonergic receptors was shown to effectively reduce seizures. Our findings therefore open new avenues for the development of future novel DS therapeutics. ..
  6. Burri A, Hysi P, Clop A, Rahman Q, Spector T. A genome-wide association study of female sexual dysfunction. PLoS ONE. 2012;7:e35041 pubmed publisher
    ..2 × 10(-7); and rs13209281 P = 8.3 × 10(-7)) on chromosome 6, around 500 kb upstream of the locus HTR1E (5-hydroxytryptamine receptor 1E) locus, related to the serotonin brain pathways...
  7. Corominas R, Sobrido M, Ribases M, Cuenca León E, Blanco Arias P, Narberhaus B, et al. Association study of the serotoninergic system in migraine in the Spanish population. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:177-84 pubmed publisher
    ..These results suggest a differential involvement of serotonin-related genes in the genetic background of MO and MA. ..
  8. Ramos Lopez O, Arpón A, Riezu Boj J, Milagro F, Mansego M, Martinez J. DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population. Appetite. 2018;120:230-239 pubmed publisher
    ..cg15947487 (CALHM1), cg11658986 (ADCY6), cg04149773 (ADCY6), cg02841941 (P2RY1), cg02315111 (P2RX2), cg08273233 (HTR1E), cg14523238 (GABBR2), cg12315353 (GABBR1) and cg05579652 (CACNA1C)...
  9. Klein M, Dukat M, Glennon R, Teitler M. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011;337:860-7 pubmed publisher
    ..The insights generated from this study will inform future drug development and molecular modeling studies for both 5-HT(1E) and 5-HT(1F) receptors. ..

More Information


  1. Zgombick J, Schechter L, Macchi M, Hartig P, Branchek T, Weinshank R. Human gene S31 encodes the pharmacologically defined serotonin 5-hydroxytryptamine1E receptor. Mol Pharmacol. 1992;42:180-5 pubmed
    ..clone hp75d is identical to that of the recently isolated, but uncharacterized, novel serotonin receptor gene S31. Transmembrane domain sequence comparison of clone hp75d with other guanine nucleotide-binding protein-coupled ..
  2. Oades R, Lasky Su J, Christiansen H, Faraone S, Sonuga Barke E, Banaschewski T, et al. The influence of serotonin- and other genes on impulsive behavioral aggression and cognitive impulsivity in children with attention-deficit/hyperactivity disorder (ADHD): Findings from a family-based association test (FBAT) analysis. Behav Brain Funct. 2008;4:48 pubmed publisher
    ..Nominal significance was shown for 12 SNPs from BDNF, DRD1, HTR1E, HTR2A, HTR3B, DAT1/SLC6A3, and TPH2 genes replicating reported associations with ADHD...
  3. Smith A, Dimulescu I, Falkenberg V, Narasimhan S, Heim C, Vernon S, et al. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology. 2008;33:188-97 pubmed
    ..A total of 77 polymorphisms in genes related to serotonin synthesis (TPH2), signaling (HTR1A, HTR1E, HTR2A, HTR2B, HTR2C, HTR3A, HTR3B, HTR4, HTR5A, HTR6, and HTR7), transport (SLC6A4), and catabolism (MAOA) were ..
  4. Turecki G, Sequeira A, Gingras Y, Seguin M, Lesage A, Tousignant M, et al. Suicide and serotonin: study of variation at seven serotonin receptor genes in suicide completers. Am J Med Genet B Neuropsychiatr Genet. 2003;118B:36-40 pubmed
    ..we investigated variation at genes that code for serotonin receptor 1B (5-HTR1B), 1Dalpha (5-HTR1Dalpha), 1E (5-HTR1E), 1F (5-HTR1F), 2C (5-HTR2C), 5A (5-HTR5A), and 6 (5-HTR6) in a total sample of 106 suicide completers and 120 ..
  5. Pierce P, Xie G, Meuser T, Peroutka S. 5-Hydroxytryptamine receptor subtype messenger RNAs in human dorsal root ganglia: a polymerase chain reaction study. Neuroscience. 1997;81:813-9 pubmed
    ..No 5-HT2C receptor subtype messenger RNA could be detected. Findings from this study may direct further efforts to determine the role of serotonin receptors in the peripheral nervous system. ..
  6. Levy F, Holtgreve Grez H, Tasken K, Solberg R, Ried T, Gudermann T. Assignment of the gene encoding the 5-HT1E serotonin receptor (S31) (locus HTR1E) to human chromosome 6q14-q15. Genomics. 1994;22:637-40 pubmed
    ..serotonin receptor was recently cloned, but no chromosomal assignment has yet been given to this gene (locus HTR1E)...
  7. Levy F, Gudermann T, Birnbaumer M, Kaumann A, Birnbaumer L. Molecular cloning of a human gene (S31) encoding a novel serotonin receptor mediating inhibition of adenylyl cyclase. FEBS Lett. 1992;296:201-6 pubmed
    We report the molecular cloning of human gene (S31) containing an open reading frame of 1095 nucleotides, which encodes a protein of 365 amino acids...
  8. McAllister G, Charlesworth A, Snodin C, Beer M, Noble A, Middlemiss D, et al. Molecular cloning of a serotonin receptor from human brain (5HT1E): a fifth 5HT1-like subtype. Proc Natl Acad Sci U S A. 1992;89:5517-21 pubmed
    ..The excellent correlation observed between the pharmacology of the expressed receptor encoded by AC1 and the human brain 5HT1E binding site confirms that AC1 encodes a 5HT1E receptor and establishes a fifth 5HT1-like receptor subtype. ..