HSPB8

Summary

Gene Symbol: HSPB8
Description: heat shock protein family B (small) member 8
Alias: CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22, heat shock protein beta-8, E2-induced gene 1 protein, alpha-crystallin C chain, heat shock 22kDa protein 8, heat shock 27kDa protein 8, protein kinase H11, small stress protein-like protein HSP22
Species: human
Products:     HSPB8

Top Publications

  1. Li B, Smith C, Laing J, Gober M, Liu L, Aurelian L. Overload of the heat-shock protein H11/HspB8 triggers melanoma cell apoptosis through activation of transforming growth factor-beta-activated kinase 1. Oncogene. 2007;26:3521-31 pubmed
    ..We report that overload of the recently cloned H11/HspB8 induces apoptosis in 55% of examined melanoma cultures...
  2. Carra S, Seguin S, Landry J. HspB8 and Bag3: a new chaperone complex targeting misfolded proteins to macroautophagy. Autophagy. 2008;4:237-9 pubmed
    ..The complex is formed of HspB8, a member of the HspB family of molecular chaperones, which is found mutated in neuromuscular diseases, and Bag3, ..
  3. Cui X, Wang N, Yang B, Gao W, Lin Y, Yao X, et al. HSPB8 is methylated in hematopoietic malignancies and overexpression of HSPB8 exhibits antileukemia effect. Exp Hematol. 2012;40:14-21 pubmed publisher
    b>HSPB8 has been shown to be involved in regulation of cell proliferation and apoptosis, and it has also been found to have divergent properties in solid tumors...
  4. Irobi J, Van Impe K, Seeman P, Jordanova A, Dierick I, Verpoorten N, et al. Hot-spot residue in small heat-shock protein 22 causes distal motor neuropathy. Nat Genet. 2004;36:597-601 pubmed
    ..3, we identified the same mutation (K141N) in small heat-shock 22-kDa protein 8 (encoded by HSPB8; also called HSP22). We found a second mutation (K141E) in two smaller families...
  5. Roelofs M, Boelens W, Joosten L, Abdollahi Roodsaz S, Geurts J, Wunderink L, et al. Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol. 2006;176:7021-7 pubmed
    ..In vitro, monocyte-derived DCs were stimulated with recombinant alphaA crystallin, alphaB crystallin, HSP20, HSPB8, and HSP27...
  6. Carra S, Seguin S, Lambert H, Landry J. HspB8 chaperone activity toward poly(Q)-containing proteins depends on its association with Bag3, a stimulator of macroautophagy. J Biol Chem. 2008;283:1437-44 pubmed
    Mutations in HspB8, a member of the B group of heat shock proteins (Hsp), have been associated with human neuromuscular disorders. However, the exact function of HspB8 is not yet clear...
  7. Sui X, Li D, Qiu H, Gaussin V, Depre C. Activation of the bone morphogenetic protein receptor by H11kinase/Hsp22 promotes cardiac cell growth and survival. Circ Res. 2009;104:887-95 pubmed publisher
    H11 kinase/Hsp22 (H11K) is a chaperone promoting cardiac cell growth and survival through the activation of Akt, a downstream effector of phosphatidylinositol 3-kinase (PI3K)...
  8. Nivon M, Abou Samra M, Richet E, Guyot B, Arrigo A, Kretz Remy C. NF-?B regulates protein quality control after heat stress through modulation of the BAG3-HspB8 complex. J Cell Sci. 2012;125:1141-51 pubmed publisher
    ..of misfolded or aggregated proteins--a process also called 'aggrephagy'--by controlling the expression of BAG3 and HSPB8 and by modulating the level of the BAG3-HspB8 complex...
  9. Smith C, Yu Y, Kulka M, Aurelian L. A novel human gene similar to the protein kinase (PK) coding domain of the large subunit of herpes simplex virus type 2 ribonucleotide reductase (ICP10) codes for a serine-threonine PK and is expressed in melanoma cells. J Biol Chem. 2000;275:25690-9 pubmed
    ..1995) Int. J. Onc. 7, 515-522). Here, we report the isolation and characterization of a novel gene, designated H11, that contains an open reading frame of 588 nucleotides, which encodes a protein similar to ICP10 PK...

More Information

Publications121 found, 100 shown here

  1. Aurelian L, Smith C, Winchurch R, Kulka M, Gyotoku T, Zaccaro L, et al. A novel gene expressed in human keratinocytes with long-term in vitro growth potential is required for cell growth. J Invest Dermatol. 2001;116:286-95 pubmed
    ..Here we report that a novel gene (H11) that codes for a protein similar to herpes simplex virus 2 ribonucleotide reductase protein kinase, is expressed ..
  2. Gober M, Smith C, Ueda K, Toretsky J, Aurelian L. Forced expression of the H11 heat shock protein can be regulated by DNA methylation and trigger apoptosis in human cells. J Biol Chem. 2003;278:37600-9 pubmed
    b>H11, the eukaryotic homologue of a herpes simplex virus protein, has the crystallin motif of heat shock proteins (Hsp), but it differs from canonical family members in that mRNA and protein levels were reduced in various tumor tissues ..
  3. Sun X, Fontaine J, Rest J, Shelden E, Welsh M, Benndorf R. Interaction of human HSP22 (HSPB8) with other small heat shock proteins. J Biol Chem. 2004;279:2394-402 pubmed
    ..Recently a new sHSP, HSP22 (HSPB8, H11), was identified in the human heart by its interaction with HSP27 (HSPB1)...
  4. Carra S, Sivilotti M, Chávez Zobel A, Lambert H, Landry J. HspB8, a small heat shock protein mutated in human neuromuscular disorders, has in vivo chaperone activity in cultured cells. Hum Mol Genet. 2005;14:1659-69 pubmed
    ..In the present study, we investigated the capacity of the sHsp, HspB8/Hsp22, to prevent protein aggregation in the cells using the polyglutamine protein Htt43Q as a model...
  5. Seidel K, Vinet J, Dunnen W, Brunt E, Meister M, Boncoraglio A, et al. The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases. Neuropathol Appl Neurobiol. 2012;38:39-53 pubmed publisher
    b>HSPB8 is a small heat shock protein that forms a complex with the co-chaperone BAG3...
  6. Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, et al. The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS). Hum Mol Genet. 2010;19:3440-56 pubmed publisher
    ..we found that spinal cord motor neurons, accumulating mutant SOD1 also over-express the small heat shock protein HspB8. Using motor neuronal fALS models, we demonstrated that HspB8 decreases aggregation and increases mutant SOD1 ..
  7. Carra S, Boncoraglio A, Kanon B, Brunsting J, Minoia M, Rana A, et al. Identification of the Drosophila ortholog of HSPB8: implication of HSPB8 loss of function in protein folding diseases. J Biol Chem. 2010;285:37811-22 pubmed publisher
    ..ataxia 3 and peripheral neuropathies associated with the K141E and K141N mutations in the small heat shock protein HSPB8. In cells, HSPB8 cooperates with BAG3 to stimulate autophagy in an eIF2?-dependent manner and facilitates the ..
  8. Boardman L, Mitchell K, Terblanche J, Sørensen J. A transcriptomics assessment of oxygen-temperature interactions reveals novel candidate genes underlying variation in thermal tolerance and survival. J Insect Physiol. 2018;106:179-188 pubmed publisher
    ..Small heat shock proteins Hsp22 and Hsp23 were upregulated after both 10 and 21kPa O2-hot treatments...
  9. Pareyson D, Saveri P, Sagnelli A, Piscosquito G. Mitochondrial dynamics and inherited peripheral nerve diseases. Neurosci Lett. 2015;596:66-77 pubmed publisher
    ..transport and mutations in some of related encoding genes cause peripheral neuropathy (TUBB3, NEFL, HSPB1, HSPB8, HSPB3, DNAJB2)...
  10. McClung J, McCord T, Ryan T, Schmidt C, Green T, Southerland K, et al. BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. Circulation. 2017;136:281-296 pubmed publisher
    ..with BAG3Met81, BAG3Ile81 displayed improved binding to the small heat shock protein (HspB8) in ischemic skeletal muscle cells and enhanced ischemic muscle autophagic flux...
  11. Zhai Y, He Z, Kang Y, Yu H, Wang J, Du P, et al. Complete nucleotide sequence of pH11, an IncHI2 plasmid conferring multi-antibiotic resistance and multi-heavy metal resistance genes in a clinical Klebsiella pneumoniae isolate. Plasmid. 2016;86:26-31 pubmed publisher
    ..Harbored by a clinical Klebsiella pneumoniae strain H11, and isolated in Beijing, this plasmid contains multiple antibiotic resistance genes, including catA2, aac(6')-Ib, ..
  12. Eichhorn I, Heidemanns K, Ulrich R, Schmidt H, Semmler T, Fruth A, et al. Lysogenic conversion of atypical enteropathogenic Escherichia coli (aEPEC) from human, murine, and bovine origin with bacteriophage Φ3538 Δstx2::cat proves their enterohemorrhagic E. coli (EHEC) progeny. Int J Med Microbiol. 2018;308:890-898 pubmed publisher
    ..A third strain, the bovine aEPEC IMT19981, was of serotype O26:H11 and ST21 (STC29). All three aEPEC were successfully lysogenized with phage Φ3538 Δstx2::cat...
  13. Qi L, Pujanauski L, Davis A, Schwartzman L, Chertow D, Baxter D, et al. Contemporary avian influenza A virus subtype H1, H6, H7, H10, and H15 hemagglutinin genes encode a mammalian virulence factor similar to the 1918 pandemic virus H1 hemagglutinin. MBio. 2014;5:e02116 pubmed publisher
    ..pathogenic in mice and cytopathic in normal human bronchial epithelial cells, in contrast to H2-, H3-, H5-, H9-, H11-, H13-, H14-, and H16-expressing viruses...
  14. Rossor A, Kalmar B, Greensmith L, Reilly M. The distal hereditary motor neuropathies. J Neurol Neurosurg Psychiatry. 2012;83:6-14 pubmed publisher
    ..The causative genes have implicated proteins with diverse functions such as protein misfolding (HSPB1, HSPB8, BSCL2), RNA metabolism (IGHMBP2, SETX, GARS), axonal transport (HSPB1, DYNC1H1, DCTN1) and cation-channel ..
  15. Kim A, Seo J, Kim W, Choi H, Kim S, Morrow G, et al. The pathogenic human Torsin A in Drosophila activates the unfolded protein response and increases susceptibility to oxidative stress. BMC Genomics. 2015;16:338 pubmed publisher
    ..ER) resident chaperone Heat shock protein cognate 3 (HSC3) and a mitochondria chaperone Heat Shock Protein 22 (HSP22) were significantly increased in the HTorA(ΔE)- expressing brains compared to the normal HTorA (HTorA(WT)) ..
  16. Xie Y, Zhou X, Zhang Z, Wang C, Sun Y, Liu T, et al. Absence of genetic structure in Baylisascaris schroederi populations, a giant panda parasite, determined by mitochondrial sequencing. Parasit Vectors. 2014;7:606 pubmed publisher
    ..schroederi populations were predominantly driven by three common haplotypes, atp6 A1, cox1 C10, and atp6 + cox1 H11. However, due to low rates of gene differentiation between the three populations, both the atp6 and cox1 genes ..
  17. Bartelt Kirbach B, Slowik A, Beyer C, Golenhofen N. Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats. Cell Stress Chaperones. 2017;22:653-663 pubmed publisher
    ..of the 11 HspBs investigated, HspB1/Hsp25, HspB3, HspB4/αA-crystallin, HspB5/αB-crystallin, HspB7/cvHsp, and HspB8/Hsp22 were significantly upregulated in the peri-infarct region of the cerebral cortex of infarcted hemispheres...
  18. Dabbaghizadeh A, Finet S, Morrow G, Moutaoufik M, Tanguay R. Oligomeric structure and chaperone-like activity of Drosophila melanogaster mitochondrial small heat shock protein Hsp22 and arginine mutants in the alpha-crystallin domain. Cell Stress Chaperones. 2017;22:577-588 pubmed publisher
    ..Interestingly, only the R110G-DmHsp22 mutant, and not the expected R109G equivalent to human R140-HspB1, R116-HspB4, and R120-HspB5, showed different structural properties compared with the DmHsp22WT. ..
  19. He Y, Fang J, Xue L, Wu J, Dawar F, Mei J. Potential contributions of heat shock proteins and related genes in sexual differentiation in yellow catfish (Pelteobagrus fulvidraco). Fish Physiol Biochem. 2017;43:465-475 pubmed publisher
    ..Hspa5, Hip, and Cdc37 were expressed more highly in ovary than in testis, whereas Hsp90?, Hspb2, Hspb8, and Hspbp1 were expressed more highly in testis than in ovary...
  20. Suarez Vega A, Gutiérrez Gil B, Arranz J. Transcriptome expression analysis of candidate milk genes affecting cheese-related traits in 2 sheep breeds. J Dairy Sci. 2016;99:6381-6390 pubmed publisher
    ..transporter (FABP4), an intermediate molecule of the citric acid cycle (SUCNR1), and 2 heat shock proteins (HSP70, HSPB8) that could be related to high protein production...
  21. Martín Folgar R, Martínez Guitarte J. Cadmium alters the expression of small heat shock protein genes in the aquatic midge Chironomus riparius. Chemosphere. 2017;169:485-492 pubmed publisher
    ..was used to evaluate the effects of acute Cd exposure to the expression profile of seven shsp genes (hsp17, hsp21, hsp22, hsp23, hsp24, hsp27, and hsp34) in C. riparius larvae...
  22. Anderson A, Baranowska Hustad M, Braathen R, Grodeland G, Bogen B. Simultaneous Targeting of Multiple Hemagglutinins to APCs for Induction of Broad Immunity against Influenza. J Immunol. 2018;200:2057-2066 pubmed publisher
    ..In this study, we have used hemagglutinin (HA) genes from each of six group 1 influenza viruses (H5, H6, H8, H9, H11, and H13), and inserted these into a DNA vaccine format that induces delivery of the HA protein Ags to MHC class II ..
  23. Ramirez A, Morris S, Maucourant S, D Ascanio I, Crescente V, Lu I, et al. A virus-like particle vaccine candidate for influenza A virus based on multiple conserved antigens presented on hepatitis B tandem core particles. Vaccine. 2018;36:873-880 pubmed publisher
    ..The polyclonal antibodies induced by Tandiflu1 can bind IAV Group 1 hemagglutinin types H1, H5, H11, H9, H16 and a conserved epitope on matrix protein 2 expressed by most strains of IAV...
  24. Bai L, Hurley D, Li J, Meng Q, Wang J, Fanning S, et al. Characterisation of multidrug-resistant Shiga toxin-producing Escherichia coli cultured from pigs in China: co-occurrence of extended-spectrum ?-lactamase- and mcr-1-encoding genes on plasmids. Int J Antimicrob Agents. 2016;48:445-8 pubmed publisher
    ..Two of the ten isolates, namely STEC-CQ09 (O116:H11/CC23/ST88) and CQ10 (O2:H32/ST3628), were selected for further study as described in this report.
  25. Meki I, Kariithi H, Ahmadi M, Parker A, Vreysen M, Vlak J, et al. Hytrosavirus genetic diversity and eco-regional spread in Glossina species. BMC Microbiol. 2018;18:143 pubmed publisher
    ..The G. pallidipes-infecting haplotypes H10, H11 and H12 (from Kenya) clustered with H7 (from Ethiopia), which presumably corresponds to the recently sequenced ..
  26. Nefedova V, Muranova L, Sudnitsyna M, Ryzhavskaya A, Gusev N. Small Heat Shock Proteins and Distal Hereditary Neuropathies. Biochemistry (Mosc). 2015;80:1734-47 pubmed publisher
    ..Data concerning point mutations of Lys141 of HspB8 and those associated with hereditary neuropathy and different forms of Charcot-Marie-Tooth disease are analyzed...
  27. La Padula V, Staszewski O, Nestel S, Busch H, Boerries M, Roussa E, et al. HSPB3 protein is expressed in motoneurons and induces their survival after lesion-induced degeneration. Exp Neurol. 2016;286:40-49 pubmed publisher
    ..Mutations in HSPBs can lead to human disease and particularly point mutations in HSPB1 and HSPB8 are known to lead to peripheral neuropathies...
  28. Schwartzman L, Cathcart A, Pujanauski L, Qi L, Kash J, Taubenberger J. An Intranasal Virus-Like Particle Vaccine Broadly Protects Mice from Multiple Subtypes of Influenza A Virus. MBio. 2015;6:e01044 pubmed publisher
    ..protection following challenge with influenza viruses expressing 1918 H1, 1957 H2, and avian H5, H6, H7, H10, and H11 hemagglutinin subtypes...
  29. Wattin M, Gaweda L, Muller P, Baritaud M, Scholtes C, Lozano C, et al. Modulation of Protein Quality Control and Proteasome to Autophagy Switch in Immortalized Myoblasts from Duchenne Muscular Dystrophy Patients. Int J Mol Sci. 2018;19: pubmed publisher
    ..This stress is combined with BAG1 to BAG3 switch, NF?B activation and up-regulation of BAG3/HSPB8 complexes that ensure preferential routing of misfolded/aggregated proteins to autophagy rather than to deficient ..
  30. Martín Folgar R, de la Fuente M, Morcillo G, Martínez Guitarte J. Characterization of six small HSP genes from Chironomus riparius (Diptera, Chironomidae): Differential expression under conditions of normal growth and heat-induced stress. Comp Biochem Physiol A Mol Integr Physiol. 2015;188:76-86 pubmed publisher
    ..a comparative study and characterized secondary structure of the six newly identified sHsp genes Hsp17, Hsp21, Hsp22, Hsp23, Hsp24, and Hsp34. A characteristic α-crystallin domain is predicted in all the new proteins...
  31. Tiwari S, Mahata M, Kumar K, Rai V. Enhanced temperature sensing response of upconversion luminescence in ZnO-CaTiO3: Er(3+)/Yb(3+) nano-composite phosphor. Spectrochim Acta A Mol Biomol Spectrosc. 2015;150:623-30 pubmed publisher
    ..bands at 410, 492, 524, 545 and 662 nm corresponding to (2)H9/2→(4)I15/2, (4)F3/2→(4)I15/2, (2)H11/2→(4)I15/2, (4)S3/2→(4)I15/2 and (4)F9/2→(4)I15/2 transitions, respectively are found under ..
  32. Moraes C, Polatto J, Rossato S, Izquierdo M, Munhoz D, Martins F, et al. Flagellin and GroEL mediates in vitro binding of an atypical enteropathogenic Escherichia coli to cellular fibronectin. BMC Microbiol. 2015;15:278 pubmed publisher
    ..Previous studies from our group demonstrated that aEPEC O26:H11 (strain BA2103) showed high binding activity to fibronectin, not shared by its counterpart, aEPEC O26:HNM...
  33. Hailmann M, Wolf N, Renner R, Schäfer T, Hupp B, Steffen A, et al. Unprecedented Efficient Structure Controlled Phosphorescence of Silver(I) Clusters Stabilized by Carba-closo-dodecaboranylethynyl Ligands. Angew Chem Int Ed Engl. 2016;55:10507-11 pubmed publisher
    Ag2 (12-C?C-closo-1-CB11 H11 )}n and selected pyridine ligands have been used for the synthesis of photostable Ag(I) clusters that, with one exception, exhibit for Ag(I) compounds unusual room-temperature phosphorescence...
  34. McArthur M, Chen W, Magder L, Levine M, Sztein M. Impact of CD4+ T Cell Responses on Clinical Outcome following Oral Administration of Wild-Type Enterotoxigenic Escherichia coli in Humans. PLoS Negl Trop Dis. 2017;11:e0005291 pubmed publisher
    ..of vials, each containing a standardized inoculum of virulent wild-type (wt) ETEC strain H10407 (serotype O78:H11 expressing colonization factor antigen I and heat-labile and heat-stable enterotoxins), were prepared under current ..
  35. Timmerman V, De Jonghe P, Simokovic S, Lofgren A, Beuten J, Nelis E, et al. Distal hereditary motor neuropathy type II (distal HMN II): mapping of a locus to chromosome 12q24. Hum Mol Genet. 1996;5:1065-9 pubmed
    ..Significant linkage was obtained with markers located at chromosome 12q24, and the gene for distal HMN II was assigned to the 13 cM interval between D12S86 and D12S340. ..
  36. Shemetov A, Gusev N. Biochemical characterization of small heat shock protein HspB8 (Hsp22)-Bag3 interaction. Arch Biochem Biophys. 2011;513:1-9 pubmed publisher
    Interaction of human Bag3 with small heat shock proteins HspB6, HspB8 and its K141E mutant was analyzed by different biochemical methods...
  37. Verma N, Gupta I, Verma A, Kumar R, Das R, Vineeth M. Novel SNPs in HSPB8 gene and their association with heat tolerance traits in Sahiwal indigenous cattle. Trop Anim Health Prod. 2016;48:175-80 pubmed publisher
    ..b>HSPB8 gene has been mapped on Bos taurus autosome 17 (BTA-17) spanning nearly 13,252 bp and comprising three exons and ..
  38. McLaren D, Previs S, Phair R, Stout S, Xie D, Chen Y, et al. Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux. J Lipid Res. 2016;57:398-409 pubmed publisher
    ..Two isotopomers ([(2)H11] and [(13)C18]) of oleic acid were administered (orally and intravenously, respectively) to serve as precursors for ..
  39. Xianwei T, Diannan L, Boxiong W. Substrate transport pathway inside outward open conformation of EmrD: a molecular dynamics simulation study. Mol Biosyst. 2016;12:2634-41 pubmed publisher
    ..of two sub-pathways, one sub-pathway, including H2, H4, and H5, and another sub-pathway, including H8, H10, and H11. The results give us have a further insight to the ways of substrate translocation of an MFS protein...
  40. Chong B, Moore E. Structure and efficient luminescence upconversion of Ln(iii) aromatic N-oxide coordination polymers. Dalton Trans. 2016;45:12200-5 pubmed publisher
    ..luminescence measurements reveal visible emission in the red, green, and blue regions corresponding to the (2)H11/2?(4)I15/2, (4)F9/2?(4)I15/2 and (2)H9/2?(4)I15/2 transitions of the Er(iii) cation upon two and three-photon ..
  41. Rauch J, Tse E, Freilich R, Mok S, Makley L, Southworth D, et al. BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins. J Mol Biol. 2017;429:128-141 pubmed publisher
    ..that BAG3 uses both of its IPV motifs to interact with sHsps, including Hsp27 (HspB1), ?B-crystallin (HspB5), Hsp22 (HspB8), and Hsp20 (HspB6)...
  42. Yu Y, Heller A, Liehr T, Smith C, Aurelian L. Expression analysis and chromosome location of a novel gene (H11) associated with the growth of human melanoma cells. Int J Oncol. 2001;18:905-11 pubmed
    We have previously described the isolation of a new human gene, H11, that codes for a 25 kDa phosphoprotein with autokinase activity the expression of which is required for cell growth...
  43. Teixidor F, Sillanpää R, Pepiol A, Lupu M, Viñas C. Synthesis of globular precursors. Chemistry. 2015;21:12778-86 pubmed publisher
    ..yield through the ring-opening reaction of cyclic oxonium compound [3,3'-Co(8-C4 H8 O2 -1,2-C2 B9 H10 )(1',2'-C2 B9 H11 )] by using terminal hydroxyl groups as nucleophiles...
  44. Callon C, Arliguie C, Montel M. Control of Shigatoxin-producing Escherichia coli in cheese by dairy bacterial strains. Food Microbiol. 2016;53:63-70 pubmed publisher
    ..mobile, Enterococcus faecalis, Enterococcus faecium, Macrococcus caseolyticus and Hafnia alvei reduced STEC O26:H11 counts by 1.4-2.5 log cfu g(-1) and to a lesser extent STEC O157:H7 counts in pasteurized milk cheeses...
  45. Kudoh A, Miyakawa K, Matsunaga S, Matsushima Y, Kosugi I, Kimura H, et al. H11/HSPB8 Restricts HIV-2 Vpx to Restore the Anti-Viral Activity of SAMHD1. Front Microbiol. 2016;7:883 pubmed publisher
    ..The screen identified H11/HSPB8 as a Vpx-binding protein that negatively regulates the stability and function of Vpx...
  46. Bruchatá K, Némethy A, Čižmáriková R, Racanská E, Habala L. Synthesis and In Vitro Pharmacological Evaluation of 5-(Alkoxymethyl)-2-(3-alkylamino-2-hydroxypropoxy)phenylethanones Related to Acebutolol and Celiprolol. Arch Pharm (Weinheim). 2016;349:733-40 pubmed publisher
    ..was expressed as ?1 /?2 ratio and the values of compounds with an alkoxy group (CH3 O, iC3 H5 O, C5 H11 O, CH2 ?CHCH2 O, CH3 OCH2 CH2 O) in the lipophilic part and with tert-butyl in the hydrophilic part of the molecule ..
  47. Crippa V, Cicardi M, Ramesh N, Seguin S, Ganassi M, Bigi I, et al. The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity. Hum Mol Genet. 2016;25:3908-3924 pubmed publisher
    ..Upregulation of HSPB8 is one possible approach for this purpose, since this chaperone promotes the clearance of an ALS associated ..
  48. Minchenko D, Novik Y, Maslak H, Tiazhka O, Minchenko O. [EXPRESSION OF PFKFB, HK2, NAMPT, TSPAN13 AND HSPB8 GENES IN PEDIATRIC GLIOMA]. Lik Sprava. 2015;:43-8 pubmed
    ..and corresponding non-malignant tissue counterparts and PFKFB1, PFKFB2, PFKFB3, PFKFB4, HK2, NAMPT, TSPAN13, and HSPB8 gene expressions were studied by quantitative polymerase chain reaction...
  49. Ganassi M, Matějů D, Bigi I, Mediani L, Poser I, Lee H, et al. A Surveillance Function of the HSPB8-BAG3-HSP70 Chaperone Complex Ensures Stress Granule Integrity and Dynamism. Mol Cell. 2016;63:796-810 pubmed publisher
    ..SGs is targeted by autophagy, whereas the majority disassembles in a process that requires assistance by the HSPB8-BAG3-HSP70 chaperone complex...
  50. Molloy M, Andrews P. Phosphopeptide derivatization signatures to identify serine and threonine phosphorylated peptides by mass spectrometry. Anal Chem. 2001;73:5387-94 pubmed
    ..The approach was further used to examine in vitro phosphorylation of recombinant human HSP22 by protein kinase C, revealing phosphorylation of Thr-63.
  51. Morrow G, Kim H, Pellerito O, Bourrelle Langlois M, Le Pécheur M, Groebe K, et al. Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a mitochondrial localization for cathepsin D. Mech Ageing Dev. 2016;155:36-47 pubmed publisher
    b>Hsp22 is a small mitochondrial heat shock protein (sHSP) preferentially up-regulated during aging in Drosophila melanogaster. Its developmental expression is strictly regulated and it is rapidly induced in conditions of stress...
  52. Wu H, Peng X, Peng X, Wu N. Isolation and molecular characterization of reassortant H11N3 subtype avian influenza viruses isolated from domestic ducks in Zhejiang Province in China. Virus Genes. 2016;52:732-7 pubmed publisher
    ..genes showed that these strains clustered in the AIV Eurasian lineage, and these strains received their genes from H11, H7, and H1 AIVs in Eastern China...
  53. Douëllou T, Delannoy S, Ganet S, Mariani Kurkdjian P, Fach P, Loukiadis E, et al. Shiga toxin-producing Escherichia coli strains isolated from dairy products - Genetic diversity and virulence gene profiles. Int J Food Microbiol. 2016;232:52-62 pubmed publisher
    ..Here we evaluate the genetic diversity of 197 strains, mainly STEC, from serotypes O157:H7, O26:H11, O103:H2, O111:H8 and O145:28 and compared strains recovered in dairy products against strains from human, meat and ..
  54. Malik A, Nagy B, Kugler R, Szmolka A. Pathogenic potential and virulence genotypes of intestinal and faecal isolates of porcine post-weaning enteropathogenic Escherichia coli. Res Vet Sci. 2017;115:102-108 pubmed publisher
    ..Intestinal EPEC isolates of sero-/intimin types O45:H11:eae-?, O49:NM:eae-?, O84:H7:eae-?, and O123:H11:eae-? formed adherent microcolonies of EPEC with AE lesions on ..
  55. Kappé G, Verschuure P, Philipsen R, Staalduinen A, Van de Boogaart P, Boelens W, et al. Characterization of two novel human small heat shock proteins: protein kinase-related HspB8 and testis-specific HspB9. Biochim Biophys Acta. 2001;1520:1-6 pubmed
    ..One of these, being the eighth known human sHsp and thus named HspB8, was recently described as a serine-threonine protein kinase (H11), but not identified as an sHsp (C.C. Smith, Y.X...
  56. Tang B, Luo W, Xia K, Xiao J, Jiang H, Shen L, et al. A new locus for autosomal dominant Charcot-Marie-Tooth disease type 2 (CMT2L) maps to chromosome 12q24. Hum Genet. 2004;114:527-33 pubmed
    ..08 for marker D12S76 at a recombination fraction (theta) of 0 strongly supported linkage to this locus. Thus, CMT2 neuropathy in this family represents a novel genetic entity that we have designated as CMT2L.
  57. Capponi S, Geroldi A, Fossa P, Grandis M, Ciotti P, Gulli R, et al. HSPB1 and HSPB8 in inherited neuropathies: study of an Italian cohort of dHMN and CMT2 patients. J Peripher Nerv Syst. 2011;16:287-94 pubmed publisher
    Mutations in the small heat-shock protein 27 kDa protein 1 (HSPB1) and 22 kDa protein 8 (HSPB8) genes were associated with distal hereditary motor neuropathy (dHMN) and with the axonal form of Charcot-Marie-Tooth disease type 2 (CMT2)...
  58. Fratev F, Tsakovska I, Al Sharif M, Mihaylova E, Pajeva I. Structural and Dynamical Insight into PPARγ Antagonism: In Silico Study of the Ligand-Receptor Interactions of Non-Covalent Antagonists. Int J Mol Sci. 2015;16:15405-24 pubmed publisher
    ..Two key interactions have been detected within the cavity between helices H3, H11 and the activation helix H12, as well as with H12...
  59. Kulshreshtha P, Tiwari A, Priyanka -, Joon S, Sinha S, Bhatnagar R. Investigation of a panel of monoclonal antibodies and polyclonal sera against anthrax toxins resulted in identification of an anti-lethal factor antibody with disease-enhancing characteristics. Mol Immunol. 2015;68:185-93 pubmed publisher
    ..EF (edema factor) and LF (lethal factor), while the other two hybridomas secreted LF-specific antibodies (H7 and H11). Single chain variable fragment (LETscFv) was derived from H10 hybridoma...
  60. Jiang W, Wang S, Chen H, Ren H, Huang X, Wang G, et al. A Bivalent Heterologous DNA Virus-Like-Particle Prime-Boost Vaccine Elicits Broad Protection against both Group 1 and 2 Influenza A Viruses. J Virol. 2017;91: pubmed publisher
    ..We show that this vaccine elicited antibody responses that bound HA from group 1 (H1, H2, H5, H6, H8, H9, H11, and H12) and group 2 (H3, H4, H7, H10, H14, and H15) and neutralized homologous and intrasubtypic H5 and H7 and ..
  61. Timmerman V, Raeymaekers P, Nelis E, De Jonghe P, Muylle L, Ceuterick C, et al. Linkage analysis of distal hereditary motor neuropathy type II (distal HMN II) in a single pedigree. J Neurol Sci. 1992;109:41-8 pubmed
    ..In this study we excluded all four regions for the presence of distal HMN II, indicating that this neuropathy is genetically different from CMT 1 and recessive SMA. ..
  62. Zhao D, Xie Z. Visible-Light-Promoted Photocatalytic B-C Coupling via a Boron-Centered Carboranyl Radical: Facile Synthesis of B(3)-Arylated o-Carboranes. Angew Chem Int Ed Engl. 2016;55:3166-70 pubmed publisher
    A visible-light-mediated in situ generation of a boron-centered carboranyl radical (o-C2 B10 H11(.)) has been described...
  63. Yamamoto N, Tokuda H, Kuroyanagi G, Kainuma S, Matsushima Nishiwaki R, Fujita K, et al. Heat shock protein 22 (HSPB8) limits TGF-?-stimulated migration of osteoblasts. Mol Cell Endocrinol. 2016;436:1-9 pubmed publisher
    ..b>HSP22 (HSPB8), a low-molecular weight HSP, is ubiquitously expressed in many cell types...
  64. Álvarez Suárez M, Otero A, García López M, Dahbi G, Blanco M, Mora A, et al. Genetic characterization of Shiga toxin-producing Escherichia coli (STEC) and atypical enteropathogenic Escherichia coli (EPEC) isolates from goat's milk and goat farm environment. Int J Food Microbiol. 2016;236:148-54 pubmed publisher
    ..All the 25 EPEC isolates were considered atypical (aEPEC) and one aEPEC strain was of serotype O26:H11, a serotype frequently isolated in children with diarrhea...
  65. Mendoza J, Schneider W, Hoffmann H, Vercauteren K, Jude K, Xiong A, et al. The IFN-λ-IFN-λR1-IL-10Rβ Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity. 2017;46:379-392 pubmed publisher
    ..We used yeast surface display to engineer a higher-affinity IFN-λ variant, H11, which enabled crystallization of the ternary complex...
  66. Shi J, Chen S, Guo C, Li Y, Ding J, Meng L. The mTOR inhibitor AZD8055 overcomes tamoxifen resistance in breast cancer cells by down-regulating HSPB8. Acta Pharmacol Sin. 2018;39:1338-1346 pubmed publisher
    ..In this study, we report that small heat protein beta-8 (HSPB8) may serve as an important molecule in tamoxifen resistance...
  67. Peferoen L, Gerritsen W, Breur M, Ummenthum K, Peferoen Baert R, van der Valk P, et al. Small heat shock proteins are induced during multiple sclerosis lesion development in white but not grey matter. Acta Neuropathol Commun. 2015;3:87 pubmed publisher
    ..We analysed transcript levels and protein distribution profiles for HSPB1, HSPB6, HSPB8 and HSPB11 in MS lesions at different stages, comparing them with normal-appearing brain tissue from MS patients ..
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  70. Suzuki M, Matsushima Nishiwaki R, Kuroyanagi G, Suzuki N, Takamatsu R, Furui T, et al. Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-α-induced ovary cancer cell migration. Arch Biochem Biophys. 2015;571:40-9 pubmed publisher
    Accumulating evidence suggests that heat shock proteins (HSPs) are implicated in progression of cancer. HSP22 (HSPB8), a small HSP, is recognized to be ubiquitously expressed in various tissues...
  71. Piccolella M, Crippa V, Cristofani R, Rusmini P, Galbiati M, Cicardi M, et al. The small heat shock protein B8 (HSPB8) modulates proliferation and migration of breast cancer cells. Oncotarget. 2017;8:10400-10415 pubmed publisher
    ..The autophagy facilitator HSPB8 has been found overexpressed in some BC...
  72. Böhnlein C, Kabisch J, Müller Herbst S, Fiedler G, Franz C, Pichner R. Persistence and reduction of Shiga toxin-producing Escherichia coli serotype O26:H11 in different types of raw fermented sausages. Int J Food Microbiol. 2017;261:82-88 pubmed publisher
    ..of serogroup O26 in food are rare, so that the aim of this study was to investigate the survival of STEC O26:H11 in different types of fermented sausages ("Teewurst", fast-ripened and long-fermented salami)...
  73. Luo S, Xie Z, Xie Z, Xie L, Huang L, Huang J, et al. Surveillance of Live Poultry Markets for Low Pathogenic Avian Influenza Viruses in Guangxi Province, Southern China, from 2012-2015. Sci Rep. 2017;7:17577 pubmed publisher
    ..Among the samples, 622 (16.3%) were positive for LPAIVs. Six subtypes (H1, H3, H4, H6, H9 and H11) were individually isolated and identified...
  74. Shemetov A, Seit Nebi A, Gusev N. Structure, properties, and functions of the human small heat-shock protein HSP22 (HspB8, H11, E2IG1): a critical review. J Neurosci Res. 2008;86:264-9 pubmed
    The recently described human HSP22 belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain...
  75. Kasakov A, Bukach O, Seit Nebi A, Marston S, Gusev N. Effect of mutations in the beta5-beta7 loop on the structure and properties of human small heat shock protein HSP22 (HspB8, H11). FEBS J. 2007;274:5628-42 pubmed
    ..and function of small heat shock proteins, we mutated two highly conservative residues (K137 and K141) of human HSP22 and investigated the properties of the K137E and K137,141E mutants...
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    ..intrinsic fluorescence) to investigate the thermal-induced changes in the structure of small heat shock protein Hsp22. It has been shown that this protein undergoes thermal-induced unfolding that occurs within a very broad ..
  77. Kaur H, Shorie M, Sharma M, Ganguli A, Sabherwal P. Bridged Rebar Graphene functionalized aptasensor for pathogenic E. coli O78:K80:H11 detection. Biosens Bioelectron. 2017;98:486-493 pubmed publisher
    ..coli O78:K80:H11. The chemical facilitated unscrolling of MWCNT and subsequent bridging with terephthalaldehyde (TPA) to form 3D-..
  78. Charpentier A, Bednarek A, Daniel R, Hawkins K, Laflin K, Gaddis S, et al. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res. 2000;60:5977-83 pubmed
    ..We cloned five novel genes (E2IG1-5), which were observed up-regulated by the hormonal treatment...
  79. Kwok A, Phadwal K, Turner B, Oliver P, Raw A, Simon A, et al. HspB8 mutation causing hereditary distal motor neuropathy impairs lysosomal delivery of autophagosomes. J Neurochem. 2011;119:1155-61 pubmed publisher
    b>HspB8, a small heat-shock protein implicated in autophagy, is mutated in patients with distal hereditary motor neuropathy type II (dHMNII)...
  80. Hu X, Hu S, Wang J, Dong Y, Zhang L, Dong Y. Steered Molecular Dynamics for Studying Ligand Unbinding of Ecdysone Receptor. J Biomol Struct Dyn. 2017;:1-28 pubmed publisher
    ..most likely exit path for BYI06830, which was located in the cleft formed by the H3-H4 loop, H6-H7 loop, and the H11 C-terminus...
  81. Tokonami S, Shimizu E, Tamura M, Iida T. Mechanism in External Field-mediated Trapping of Bacteria Sensitive to Nanoscale Surface Chemical Structure. Sci Rep. 2017;7:16651 pubmed publisher
    ..Particularly, we reveal the rapid specific identification of E. coli group serotypes (O157:H7 and O26:H11) using an alternating electric field and a quartz crystal microbalance...
  82. Berciano J, Combarros O, Figols J, Calleja J, Cabello A, Silos I, et al. Hereditary motor and sensory neuropathy type II. Clinicopathological study of a family. Brain. 1986;109 ( Pt 5):897-914 pubmed
    ..These anatomical findings are consistent with the hypothesis that HMSN type II represents a primary neuronopathy affecting motor and sensory neurons. ..
  83. Irobi J, Tissir F, De Jonghe P, De Vriendt E, Van Broeckhoven C, Timmerman V, et al. A clone contig of 12q24.3 encompassing the distal hereditary motor neuropathy type II gene. Genomics. 2000;65:34-43 pubmed
    ..This physical map provides a valuable resource for mapping genes and markers located within the distal HMN II region and facilitates the positional cloning of the distal HMN II gene. ..
  84. Kim M, Seit Nebi A, Marston S, Gusev N. Some properties of human small heat shock protein Hsp22 (H11 or HspB8). Biochem Biophys Res Commun. 2004;315:796-801 pubmed
    Untagged recombinant human small heat shock protein with apparent molecular mass 22 kDa (Hsp22) was obtained in homogeneous state...
  85. Fuchs M, Poirier D, Seguin S, Lambert H, Carra S, Charette S, et al. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem J. 2009;425:245-55 pubmed publisher
    The molecular chaperone HspB8 [Hsp (heat-shock protein) B8] is member of the B-group of Hsps. These proteins bind to unfolded or misfolded proteins and protect them from aggregation...
  86. Echaniz Laguna A, Geuens T, Petiot P, Pereon Y, Adriaenssens E, Haidar M, et al. Axonal Neuropathies due to Mutations in Small Heat Shock Proteins: Clinical, Genetic, and Functional Insights into Novel Mutations. Hum Mutat. 2017;38:556-568 pubmed publisher
    ..spectrum of distal hereditary motor neuropathy caused by mutations in the small heat shock proteins HSPB1 and HSPB8 and investigate the functional consequences of newly discovered variants...
  87. Moran Gilad J, Rokney A, Danino D, Ferdous M, Alsana F, Baum M, et al. Real-time genomic investigation underlying the public health response to a Shiga toxin-producing Escherichia coli O26:H11 outbreak in a nursery. Epidemiol Infect. 2017;145:2998-3006 pubmed publisher
    ..sequencing (WGS) was used for real-time investigation of the incident and revealed a unique strain of STEC O26:H11 carrying stx2a and intimin. Following a public health intervention, no additional cases have occurred...
  88. Kim M, Seit Nebi A, Gusev N. The problem of protein kinase activity of small heat shock protein Hsp22 (H11 or HspB8). Biochem Biophys Res Commun. 2004;325:649-52 pubmed
    The recently described protein denoted H11, Hsp22 or HspB8 seems to participate in regulation of proliferation, apoptosis, and cardiac hypertrophy. Mutation of Hsp22 causes distal motor neuropathy...
  89. Badri K, Modem S, Gerard H, Khan I, Bagchi M, Hudson A, et al. Regulation of Sam68 activity by small heat shock protein 22. J Cell Biochem. 2006;99:1353-62 pubmed
    ..In the present study, we identified small heat shock protein, hsp22, as a novel interacting partner of Sam68. Hsp22 binds to Sam68 in vitro and in vivo...
  90. Sengar G, Deb R, Singh U, Raja T, Kant R, Sajjanar B, et al. Differential expression of microRNAs associated with thermal stress in Frieswal (Bos taurus x Bos indicus) crossbred dairy cattle. Cell Stress Chaperones. 2018;23:155-170 pubmed publisher
    ..profile during peak summer, bta-miR-2898 was chosen for reporter assay to identify its effect on the target HSPB8 (heat shock protein 22) gene in stressed bovine PBMC cell cultured model...
  91. Modem S, Chinnakannu K, Bai U, Reddy G, Reddy T. Hsp22 (HspB8/H11) knockdown induces Sam68 expression and stimulates proliferation of glioblastoma cells. J Cell Physiol. 2011;226:2747-51 pubmed publisher
    ..We previously reported that heat shock protein-22 (Hsp22) antagonizes Sam68 function in rev-response element (RRE)-mediated gene expression...