HSPB6

Summary

Gene Symbol: HSPB6
Description: heat shock protein family B (small) member 6
Alias: HEL55, Hsp20, PPP1R91, heat shock protein beta-6, epididymis luminal protein 55, heat shock 20 kDa-like protein p20, heat shock protein family B (small) member B6, heat shock protein, alpha-crystallin-related, B6, protein phosphatase 1, regulatory subunit 91
Species: human
Products:     HSPB6

Top Publications

  1. Sluchanko N, Sudnitsyna M, Seit Nebi A, Antson A, Gusev N. Properties of the monomeric form of human 14-3-3? protein and its interaction with tau and HspB6. Biochemistry. 2011;50:9797-808 pubmed publisher
    ..Using WMW and MMW mutants, we show that the monomeric form interacts with the tau protein and with the HspB6 protein, in both cases forming complexes with a 1:1 stoichiometry, in contrast to the 2:1 and/or 2:2 complexes ..
  2. Kappé G, Franck E, Verschuure P, Boelens W, Leunissen J, de Jong W. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. Cell Stress Chaperones. 2003;8:53-61 pubmed
    ..the 9 earlier recognized human sHsps (Hsp27/HspB1, HspB2, HspB3, alphaA-crystallin/HspB4, alphaB-crystallin/HspB5, Hsp20/HspB6, cvHsp/HspB7, H11/HspB8, and HspB9) and a sperm tail protein known since 1993 as outer dense fiber protein 1 ..
  3. Sudnitsyna M, Seit Nebi A, Gusev N. Cofilin weakly interacts with 14-3-3 and therefore can only indirectly participate in regulation of cell motility by small heat shock protein HspB6 (Hsp20). Arch Biochem Biophys. 2012;521:62-70 pubmed publisher
    ..weakly interacts with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3...
  4. Tessier D, Komalavilas P, Panitch A, Joshi L, Brophy C. The small heat shock protein (HSP) 20 is dynamically associated with the actin cross-linking protein actinin. J Surg Res. 2003;111:152-7 pubmed
    ..We hypothesized that HSP20 mediates vasorelaxation via dynamic interactions with cytoskeletal proteins, such as actin, or actin binding ..
  5. Bukach O, Seit Nebi A, Marston S, Gusev N. Some properties of human small heat shock protein Hsp20 (HspB6). Eur J Biochem. 2004;271:291-302 pubmed
    Human heat shock protein of apparent molecular mass 20 kDa (Hsp20) and its mutant, S16D, mimicking phosphorylation by cyclic nucleotide-dependent protein kinases, were cloned and expressed in Escherichia coli...
  6. Bagneris C, Bateman O, Naylor C, Cronin N, Boelens W, Keep N, et al. Crystal structures of alpha-crystallin domain dimers of alphaB-crystallin and Hsp20. J Mol Biol. 2009;392:1242-52 pubmed publisher
    ..Here, crystal structures of excised alpha-crystallin domain from rat Hsp20 and that from human alphaB-crystallin show that they form homodimers with a shared groove at the interface by ..
  7. Sluchanko N, Sudnitsyna M, Chernik I, Seit Nebi A, Gusev N. Phosphomimicking mutations of human 14-3-3? affect its interaction with tau protein and small heat shock protein HspB6. Arch Biochem Biophys. 2011;506:24-34 pubmed publisher
    ..with phosphorylated shortest isoform of human tau protein and phosphorylated human small heat shock protein HspB6 (Hsp20) was analyzed...
  8. Baranova E, Weeks S, Beelen S, Bukach O, Gusev N, Strelkov S. Three-dimensional structure of ?-crystallin domain dimers of human small heat shock proteins HSPB1 and HSPB6. J Mol Biol. 2011;411:110-22 pubmed publisher
    ..and solution small-angle X-ray scattering (SAXS) to study the ACD-containing fragments of human HSPB1 (HSP27) and HSPB6 (HSP20)...
  9. Chernik I, Seit Nebi A, Marston S, Gusev N. Small heat shock protein Hsp20 (HspB6) as a partner of 14-3-3gamma. Mol Cell Biochem. 2007;295:9-17 pubmed
    Interaction of human 14-3-3gamma with the small heat shock protein Hsp20 was analyzed by means of size-exclusion chromatography and chemical crosslinking...

More Information

Publications126 found, 100 shown here

  1. Kim J, Lim S, Jang C. Oryza sativa heat-induced RING finger protein 1 (OsHIRP1) positively regulates plant response to heat stress. Plant Mol Biol. 2019;99:545-559 pubmed publisher
    ..Some heat stress-inducible genes (HsfA3, HSP17.3, HSP18.2 and HSP20) were up-regulated in OsHIRP1-overexpressing Arabidopsis than control plants under heat stress conditions...
  2. Rosa A, Moncau C, Poleti M, Fonseca L, Balieiro J, Silva S, et al. Proteome changes of beef in Nellore cattle with different genotypes for tenderness. Meat Sci. 2018;138:1-9 pubmed publisher
    ..myosin (MYL1, MYL2, MYLPF and MYL6B), actin (ACTA1 and CAPZ?), troponin (TNNT1 and TNNT3) and heat shock proteins (HSPB6, HSPB1 and HSP70-2)...
  3. Contreras Castillo C, Lomiwes D, Wu G, Frost D, Farouk M. The effect of electrical stimulation on post mortem myofibrillar protein degradation and small heat shock protein kinetics in bull beef. Meat Sci. 2016;113:65-72 pubmed publisher
    ..Electrical stimulation significantly affected the variable levels of αβ-crystallin and HSP20 with higher concentrations of these sHSP in ES muscles at later ageing timepoints compared with NS muscles.
  4. Picard B, Gagaoua M, Micol D, Cassar Malek I, Hocquette J, Terlouw C. Inverse relationships between biomarkers and beef tenderness according to contractile and metabolic properties of the muscle. J Agric Food Chem. 2014;62:9808-18 pubmed publisher
    ..Proteins such as lactate dehydrogenase-B, myosin heavy chain IIx, and small heat shock proteins (Hsp27, Hsp20, and αB-crystallin) were related to tenderness but inversely according to the muscle and breed...
  5. Bolhassani A, Shahbazi S, Agi E, Haghighipour N, Hadi A, Asgari F. Modified DCs and MSCs with HPV E7 antigen and small Hsps: Which one is the most potent strategy for eradication of tumors?. Mol Immunol. 2019;108:102-110 pubmed publisher
    ..Our data revealed that DCs pulsed with E7+Hsp27 and/or E7+Hsp20 in homologous and heterologous prime/ boost vaccinations could stimulate high levels of IgG2a, IgG2b, IFN-γ and ..
  6. Picard B, Gagaoua M, Al Jammas M, Bonnet M. Beef tenderness and intramuscular fat proteomic biomarkers: Effect of gender and rearing practices. J Proteomics. 2019;200:1-10 pubmed publisher
    ..A positive correlation between the abundance of the small HSP20 and slaughter age was observed in the 5 muscles...
  7. Chen S, Weng C, Lai M, Tamaki H, Narihiro T. Comparative genomic analyses reveal trehalose synthase genes as the signature in genus Methanoculleus. Mar Genomics. 2019;: pubmed publisher
    ..trehalose synthase genes are comprised of the signaling module of Per-Arnt-Sim (PAS) domain-containing proteins, Hsp20 family proteins, arabinose efflux permeases and multiple surface proteins with fasciclin-like (FAS) repeat...
  8. Zhang X, Yin F, Xiao S, Jiang C, Yu T, Chen L, et al. Proteomic analysis of the rice (Oryza officinalis) provides clues on molecular tagging of proteins for brown planthopper resistance. BMC Plant Biol. 2019;19:30 pubmed publisher
    ..A heat shock protein (HSP20) may take part in the physiological response to BPH infestation, making it a potential target for marker-assisted ..
  9. Wang J, Wang W, Wang H, Yuan F, Xu Z, Yang K, et al. Improvement of stress tolerance and riboflavin production of Bacillus subtilis by introduction of heat shock proteins from thermophilic bacillus strains. Appl Microbiol Biotechnol. 2019;: pubmed publisher
    ..Among them, strains B.s446-HSP20-3, B.s446-HSP20-2, and B.s446-PtDnaK-PtDnaJ-PtGrpE increased their cell densities over 25% at 44 to 48 °C...
  10. Ying H, Cooke I, Sprungala S, Wang W, Hayward D, Tang Y, et al. Comparative genomics reveals the distinct evolutionary trajectories of the robust and complex coral lineages. Genome Biol. 2018;19:175 pubmed publisher
    ..are apparent in the distribution and numbers of protein domains and an apparent correlation between number of HSP20 proteins and stress tolerance...
  11. Jhan P, Shim J, Lee S, Lee K. Differential responses between a vector species Bemisia tabaci and a nonvector species Trialeurodes vaporariorum following ingestion of tomato yellow leaf curl virus. Arch Insect Biochem Physiol. 2019;100:e21503 pubmed publisher
    ..In addition, TYLCV-ingested B. tabaci increased their levels of three heat shock protein genes ( hsp20, hsp70, and hsp90) against thermal stress, whereas TYLCV-ingested T. vaporariorum did not...
  12. Roy M, Gupta S, Patranabis S, Ghosh A. The oligomeric plasticity of Hsp20 of Sulfolobus acidocaldarius protects environment-induced protein aggregation and membrane destabilization. Biochim Biophys Acta Biomembr. 2018;1860:2549-2565 pubmed publisher
    ..Here, we investigated the structural and functional properties of Hsp20 from thermoacidophilic crenarchaeon Sulfolobus acidocaldarius...
  13. Gerthoffer W, Solway J, Camoretti Mercado B. Emerging targets for novel therapy of asthma. Curr Opin Pharmacol. 2013;13:324-30 pubmed publisher
    ..continues to be a promising drug target with the emergence of new PDE inhibitors and a novel PKA target protein, HSP20, which mediates smooth muscle relaxation via actin depolymerization...
  14. Li J, Zhang J, Jia H, Yue Z, Lu M, Xin X, et al. Genome-Wide Characterization of the sHsp Gene Family in Salix suchowensis Reveals Its Functions under Different Abiotic Stresses. Int J Mol Sci. 2018;19: pubmed publisher
    ..Though the gene structure and conserved motif were relatively conserved, the sequences of the Hsp20 domain were diversified...
  15. He Y, Fan M, Sun Y, Li L. Genome-Wide Analysis of Watermelon HSP20s and Their Expression Profiles and Subcellular Locations under Stresses. Int J Mol Sci. 2018;20: pubmed publisher
    ..In this study, we identified 44 watermelon HSP20 genes and analyzed their gene structures, conserved domains, phylogenetic relationships, chromosomal ..
  16. Li F, He M, Yang M, Fan Y, Chen Y, Xia X, et al. Alteration of heat shock protein 20 expression in preeclamptic patients and its effect in vascular and coagulation function. Front Med. 2018;12:542-549 pubmed publisher
    ..Heat shock protein 20 (HSP20) is ubiquitously expressed under normal physiological conditions and has important roles in vascular dilatation ..
  17. Liu X, Yu X, Xu X, Zhang X, Zhang X. The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism. Food Funct. 2018;9:5936-5949 pubmed publisher
    ..high-dose-specific TPG (Mtco3, Gal-6, Mptx, S100 g and Hpx) and low-dose-specific TPG (Zg16, Hexb, Insl5, Cept1, Hspb6 and Ifi27l2b), suggesting the complex acting mechanism of CMP33...
  18. Olguín N, Valdés La Hens D, Delfederico L, Semorile L. Relative expression of stress-related genes during acclimation at low temperature of psychrotrophic Oenococcus oeni strains from Patagonian wine. World J Microbiol Biotechnol. 2018;35:5 pubmed publisher
    ..rmlB and hsp20 genes presented a considerable increase in their expression level when strains were acclimated at 18 °C ..
  19. Aquilino M, Sánchez Argüello P, Novo M, Martínez Guitarte J. Effects on tadpole snail gene expression after exposure to vinclozolin. Ecotoxicol Environ Saf. 2019;170:568-577 pubmed publisher
    ..genes related to detoxification mechanisms (Cyp2u1, Cyp3a7, Cyp4f22, GSTo1, GSTt2, and MRP1), stress response (Hsp20.4, Hsp17, Hsp16...
  20. Shatov V, Weeks S, Strelkov S, Gusev N. The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8. Int J Mol Sci. 2018;19: pubmed publisher
    ..role of the first arginine residue of this conserved octet sequence in five human sHsps (HspB1, HspB4, HspB5, HspB6, and HspB8)...
  21. Popović Å, Subotić A, Nikolić T, Radojičić R, Blagojević D, Grubor LajÅ¡ić G, et al. Expression of stress-related genes in diapause of European corn borer (Ostrinia nubilalis Hbn.). Comp Biochem Physiol B Biochem Mol Biol. 2015;186:1-7 pubmed publisher
    ..Trx), glutaredoxin (Grx), ferritin (Fer), metallothionein (Mtn), and heat shock proteins Hsp90, Hsc70, Hsp20.4, and Hsp20...
  22. Ahmad S, Kabir M, Hayat M. Identification of Heat Shock Protein families and J-protein types by incorporating Dipeptide Composition into Chou's general PseAAC. Comput Methods Programs Biomed. 2015;122:165-74 pubmed publisher
    ..On the basis of functionality, HSPs are categorized into six major families namely: (i) HSP20 or sHSP (ii) HSP40 or J-proteins types (iii) HSP60 or GroEL/ES (iv) HSP70 (v) HSP90 and (vi) HSP100...
  23. Li J, Wei G, Wang L, Qian C, Li K, Zhang C, et al. KPNA3-knockdown eliminates the second heat shock protein peak associated with the heat shock response of male silkworm pupae (Bombyx mori) by reducing heat shock factor transport into the nucleus. Gene. 2016;575:452-457 pubmed publisher
    ..mori pupae for 30 min, we identified two heat shock protein (HSP) mRNA expression peaks correlating with HSP19.9, HSP20.4 and HSP25.4 at 4 h (peak 1) and 24 h (peak 2). The second peak was eliminated after knockdown of KPNA3...
  24. Malheiros J, Braga C, Grove R, Ribeiro F, Calkins C, Adamec J, et al. Influence of oxidative damage to proteins on meat tenderness using a proteomics approach. Meat Sci. 2019;148:64-71 pubmed publisher
    ..T (TNNT1 and TNNT3), antioxidant proteins (PRDX1, PRDX2 and PARK7) and heat shock proteins (HSPB1, CRYAB and HSPB6) showed an increase in the oxidative damage in tender meat when compared to the intermediate and tough meat (P &..
  25. Ghosh A. Small heat shock proteins (HSP12, HSP20 and HSP30) play a role in Ustilago maydis pathogenesis. FEMS Microbiol Lett. 2014;361:17-24 pubmed
    ..maydis This has been further confirmed by generation of deletion and complementation strains of three putative small HSPs. ..
  26. Peng J, Li Y, Wang X, Deng S, Holland J, Yates E, et al. An Hsp20-FBXO4 Axis Regulates Adipocyte Function through Modulating PPARγ Ubiquitination. Cell Rep. 2018;23:3607-3620 pubmed publisher
    ..Here, we demonstrate a critical role of Hsp20 as a negative regulator of adipocyte function...
  27. Yan Z, Wei H, Ren C, Yuan S, Fu H, Lv Y, et al. Gene expression of Hsps in normal and abnormal embryonic development of mouse hindlimbs. Hum Exp Toxicol. 2015;34:563-74 pubmed publisher
    ..Our previous studies found that Hsp25, HspB2, HspB3, HspB7, Hsp20, HspB9, HspB10, and Hsp40 may be related to all-trans retinoic acid (atRA)-induced phocomelic and other ..
  28. Bakthisaran R, Tangirala R, Rao C. Small heat shock proteins: Role in cellular functions and pathology. Biochim Biophys Acta. 2015;1854:291-319 pubmed publisher
    ..B-crystallin and Hsp20 exhitbit anti-platelet aggregation: these beneficial effects indicate their use as potential therapeutic agents...
  29. Chou W, Liu Y, Lin C, Lin M, Chen C, Liu W, et al. Exercise Rehabilitation Attenuates Cognitive Deficits in Rats with Traumatic Brain Injury by Stimulating the Cerebral HSP20/BDNF/TrkB Signalling Axis. Mol Neurobiol. 2018;55:8602-8611 pubmed publisher
    ..in rats with TBI and determined the contribution of hippocampal and cortical expression of heat shock protein 20 (HSP20) to PE-mediated cognitive recovery...
  30. Haghighi K, Bidwell P, Kranias E. Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend. J Mol Cell Cardiol. 2014;77:160-7 pubmed publisher
    ..These include the inhibitor-1 (I-1) of protein phosphatase 1 (PP1), the small heat shock protein 20 (Hsp20) and the HS-1 associated protein X-1 (HAX1)...
  31. Zhang C, Dai L, Wang L, Qian C, Wei G, Li J, et al. Eicosanoids mediate sHSP 20.8 gene response to biotic stress in larvae of the Chinese oak silkworm Antheraea pernyi. Gene. 2015;562:32-9 pubmed publisher
    ..pernyi; Lepidoptera: Saturniidae), cDNA encoding HSP20.8 in A. pernyi, termed Ap-sHSP20.8, was identified as a 564 bp ORF...
  32. Sin Y, Baillie G. Heat shock protein 20 (HSP20) is a novel substrate for protein kinase D1 (PKD1). Cell Biochem Funct. 2015;33:421-6 pubmed publisher
    Heat shock protein 20 (HSP20) has cardioprotective qualities, which are triggered by PKA phosphorylation. PKD1 is also a binding partner for HSP20, and this prompted us to investigate whether the chaperone was a substrate for PKD1...
  33. Aoyama H, Saitoh S, Kuroiwa T, Nakamura S. Comparative analysis of zygospore transcripts during early germination in Chlamydomonas reinhardtii. J Plant Physiol. 2014;171:1685-92 pubmed publisher
    ..Meanwhile, three uncharacterized genes that contained an antibiotic biosynthesis monooxygenase domain and an HSP20/alpha crystallin family protein were specifically expressed at 1h after light exposure...
  34. Kim B, Rhee J, Lee K, Kim M, Shin K, Lee S, et al. UV-B radiation-induced oxidative stress and p38 signaling pathway involvement in the benthic copepod Tigriopus japonicus. Comp Biochem Physiol C Toxicol Pharmacol. 2015;167:15-23 pubmed publisher
    ..japonicus. Of the hsp family genes, transcriptional levels of hsp20, hsp20...
  35. Sluchanko N, Chebotareva N, Gusev N. Quaternary structure of human small heat shock protein HSPB6 (Hsp20) in crowded media modeled by trimethylamine N-oxide (TMAO): Effect of protein phosphorylation. Biochimie. 2015;108:68-75 pubmed publisher
    ..crowded intracellular conditions, on the quaternary structure of recombinant human small heat shock protein HspB6 (Hsp20) was analyzed by means of size-exclusion chromatography, chemical crosslinking and analytical ultracentrifugation...
  36. Lupoli T, Fay A, Adura C, Glickman M, Nathan C. Reconstitution of a Mycobacterium tuberculosis proteostasis network highlights essential cofactor interactions with chaperone DnaK. Proc Natl Acad Sci U S A. 2016;113:E7947-E7956 pubmed
    ..of the Mtb ClpB/DnaK bichaperone system with the cofactors DnaJ1, DnaJ2, and GrpE and the small heat shock protein Hsp20. We found that DnaJ1 and DnaJ2 activate the ATPase activity of DnaK differently...
  37. Longo V, Lana A, Bottero M, Zolla L. Apoptosis in muscle-to-meat aging process: The omic witness. J Proteomics. 2015;125:29-40 pubmed publisher
    ..and our evidences push towards the apoptotic behavior: the proteomic time course trend of annexin A2, RKIP, HSPB6, αB crystalline, adenylate kinase, DJ-1 and 31kDa actin fragment; the 0-1day increased phosphorylation of ..
  38. Hocking K, Evans B, Komalavilas P, Cheung Flynn J, Duvall C, Brophy C. Nanotechnology Enabled Modulation of Signaling Pathways Affects Physiology in Intact Vascular Tissue. Tissue Eng Part A. 2018;: pubmed publisher
    ..SAH vasospasm is associated with decreased phosphorylation of intracellular heat shock protein 20 (HSP20) and increased phosphorylation of heat shock protein 27 (HSP27)...
  39. Li W, Liu J, Zou D, Cai X, Wang J, Wang J, et al. Exploration of bladder cancer molecular mechanisms based on miRNA-mRNA regulatory network. Oncol Rep. 2017;37:1461-1468 pubmed publisher
    ..Then, activation of HspB6 induced the angiogenesis process which provides necessary nutrition and oxygen for tumor cells...
  40. Sin Y, Martin T, Wills L, Currie S, Baillie G. Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Commun Signal. 2015;13:16 pubmed publisher
    ..We have identified a novel complex between PKD1 and a heat shock protein (Hsp), Hsp20, which has been implicated as cardioprotective...
  41. Williams T, Liao Y, Ye J, Kuchel R, Poljak A, Raftery M, et al. Cold adaptation of the Antarctic haloarchaea Halohasta litchfieldiae and Halorubrum lacusprofundi. Environ Microbiol. 2017;19:2210-2227 pubmed publisher
    ..Hrr. lacusprofundi also formed biofilms and synthesized high levels of Hsp20 chaperones. Hht...
  42. Liu L, Chen J, Yang B, Wang Y. Crystal structure and function of an unusual dimeric Hsp20.1 provide insight into the thermal protection mechanism of small heat shock proteins. Biochem Biophys Res Commun. 2015;458:429-34 pubmed publisher
    ..Here, we report the Sulfolobus solfataricus Hsp20.1 ACD dimer structure, which shows a distinct dimeric interface. We observed that, in the absence of β6, Hsp20...
  43. Zeng L, Tan J, Lu W, Hu Z. Blockade of Ser16-Hsp20 phosphorylation attenuates neuroprotection dependent upon Bcl-2 and Bax. Curr Neurovasc Res. 2013;10:208-15 pubmed
    ..b>Hsp20, one of the small heat shock proteins, has been implicated in multiple physiological and pathophysiological ..
  44. Neishabouri S, Hutson S, Davoodi J. Chronic activation of mTOR complex 1 by branched chain amino acids and organ hypertrophy. Amino Acids. 2015;47:1167-82 pubmed publisher
    ..b>HSP20, HSP27 and GAPDH were also increased in the heart but not gastrocnemius, consistent with mTORC1 activation...
  45. Costantini A, Rantsiou K, Majumder A, Jacobsen S, Pessione E, Svensson B, et al. Complementing DIGE proteomics and DNA subarray analyses to shed light on Oenococcus oeni adaptation to ethanol in wine-simulated conditions. J Proteomics. 2015;123:114-27 pubmed publisher
    ..different stress responses: in mild ethanol stress (8%), chaperones with prevalent refolding activity (like HSP20) were over-expressed, whereas at higher alcohol concentration (12%), together with HSP20 and the refolding DNAJ/K, ..
  46. Deng Y, Zheng H, Yan Z, Liao D, Li C, Zhou J, et al. Full-Length Transcriptome Survey and Expression Analysis of Cassia obtusifolia to Discover Putative Genes Related to Aurantio-Obtusin Biosynthesis, Seed Formation and Development, and Stress Response. Int J Mol Sci. 2018;19: pubmed publisher
    ..Meanwhile, most members of Hsp20 genes showed high expression level in seed and flower; seven of which might have chaperon activities under various ..
  47. Hu T, Sun X, Zhang X, Nevo E, Fu J. An RNA sequencing transcriptome analysis of the high-temperature stressed tall fescue reveals novel insights into plant thermotolerance. BMC Genomics. 2014;15:1147 pubmed publisher
    ..Low molecular weight heat shock protein (LMW-HSP, HSP20) showed activated in two stressed genotypes and high molecular weight HSP (HMW-HSP, HSP90) just in PI578718...
  48. Yang Z, Zhuang L, Szatmary P, Wen L, Sun H, Lu Y, et al. Upregulation of heat shock proteins (HSPA12A, HSP90B1, HSPA4, HSPA5 and HSPA6) in tumour tissues is associated with poor outcomes from HBV-related early-stage hepatocellular carcinoma. Int J Med Sci. 2015;12:256-63 pubmed publisher
    ..001). In contrast, HSPB6, HSPB7, HSPA6, HSPB2 and HSPB3 were upregulated in non-tumour tissues (all P < 0.001)...
  49. Morelli F, Mediani L, Heldens L, Bertacchini J, Bigi I, Carrà A, et al. An interaction study in mammalian cells demonstrates weak binding of HSPB2 to BAG3, which is regulated by HSPB3 and abrogated by HSPB8. Cell Stress Chaperones. 2017;22:531-540 pubmed publisher
    ..Interaction of HSPB8 with BAG3 regulates its stability and function. Weak association of HSPB5 and HSPB6 with BAG3 has been also reported upon overexpression in cells, supporting the idea that BAG3 might indirectly ..
  50. Eguchi T, Calderwood S, Takigawa M, Kubota S, Kozaki K. Intracellular MMP3 Promotes HSP Gene Expression in Collaboration With Chromobox Proteins. J Cell Biochem. 2017;118:43-51 pubmed publisher
    ..We found that mRNA levels of HSP family members (HSP70B', HSP72, HSP40/DNAJ, and HSP20/CRYAB) are upregulated by the intracellular MMP3 overload...
  51. Khamis I, Chan D, Shirriff C, Campbell J, Heikkila J. Expression and localization of the Xenopus laevis small heat shock protein, HSPB6 (HSP20), in A6 kidney epithelial cells. Comp Biochem Physiol A Mol Integr Physiol. 2016;201:12-21 pubmed publisher
    ..We now report the analysis of X. laevis HSPB6, an ortholog of mammalian HSPB6. X...
  52. Li Y, Baldwin T, Wang Y, Subramaniam J, Carbajal A, Brand C, et al. Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction. Sci Rep. 2017;7:5522 pubmed publisher
    ..patterns are not altered in AC9-/- heart, however, basal phosphorylation of heat shock protein 20 (Hsp20) is significantly decreased...
  53. Jiang S, Zhang Q, Su Y, Pan L. Network-Based Differential Analysis to Identify Molecular Features of Tumorigenesis for Esophageal Squamous Carcinoma. Molecules. 2018;23: pubmed publisher
    ..In addition, six genes (RBPMS2, PDK4, IGK, SBSN, IFIT3 and HSPB6) were likely to be the biomarkers of tumorigenesis for esophageal squamous carcinoma due to the fact that the ..
  54. Qiu C, Li H, Li J, Qin R, Xu R, Yang Y, et al. Isolation and characterization of three cadmium-inducible promoters from Oryza sativa. J Biotechnol. 2015;216:11-9 pubmed publisher
    ..genes in the rice genome: two tau class glutathione S-transferase (GSTU) genes, OsGSTU5 and OsGSTU37, and an HSP20/alpha crystallin family protein gene, OsHSP18.6...
  55. Muranova L, Perfilov M, Serebryakova M, Gusev N. Effect of methylglyoxal modification on the structure and properties of human small heat shock protein HspB6 (Hsp20). Cell Stress Chaperones. 2016;21:617-29 pubmed publisher
    Human small heat shock protein HspB6 (Hsp20) was modified by metabolic ?-dicarbonyl compound methylglyoxal (MGO). At low MGO/HspB6 molar ratio, Arg13, Arg14, Arg27, and Arg102 were the primary sites of MGO modification...
  56. Wang X, Gu H, Huang W, Peng J, Li Y, Yang L, et al. Hsp20-Mediated Activation of Exosome Biogenesis in Cardiomyocytes Improves Cardiac Function and Angiogenesis in Diabetic Mice. Diabetes. 2016;65:3111-28 pubmed publisher
    ..We recently showed that diabetic cardiomyocytes could release detrimental exosomes, which contain lower levels of Hsp20 than normal ones...
  57. Heirbaut M, Lermyte F, Martin E, Beelen S, Verschueren T, Sobott F, et al. The preferential heterodimerization of human small heat shock proteins HSPB1 and HSPB6 is dictated by the N-terminal domain. Arch Biochem Biophys. 2016;610:41-50 pubmed publisher
    ..Here we study the oligomers formed between human HSPB1 and HSPB6. Using small-angle X-ray scattering we could characterize two distinct heterooligomeric species present in ..
  58. Nefedova V, Sudnitsyna M, Gusev N. Interaction of small heat shock proteins with light component of neurofilaments (NFL). Cell Stress Chaperones. 2017;22:467-479 pubmed publisher
    ..HspB6 (Hsp20) and HspB8 (Hsp22) were less effective than HspB1 (or HspB5) in modulation of NFL assembly...
  59. Zhong B, Hu Z, Tan J, Lu T, Lei Q, Chen C, et al. Hsp20 Protects against Oxygen-Glucose Deprivation/Reperfusion-Induced Golgi Fragmentation and Apoptosis through Fas/FasL Pathway. Oxid Med Cell Longev. 2015;2015:606934 pubmed publisher
    ..Protective effects of Hsp20, a potential cytoprotective agent due to its chaperone-like activity and involvement in regulation of many vital ..
  60. Bartelt Kirbach B, Moron M, Glomb M, Beck C, Weller M, Golenhofen N. HspB5/?B-crystallin increases dendritic complexity and protects the dendritic arbor during heat shock in cultured rat hippocampal neurons. Cell Mol Life Sci. 2016;73:3761-75 pubmed publisher
    ..density were not affected by any HspB, dendritic complexity was enhanced by HspB5 and, to a lesser extent, by HspB6. Furthermore, we could show that this process was dependent on phosphorylation, since a non-phosphorylatable ..
  61. Rauch J, Tse E, Freilich R, Mok S, Makley L, Southworth D, et al. BAG3 Is a Modular, Scaffolding Protein that physically Links Heat Shock Protein 70 (Hsp70) to the Small Heat Shock Proteins. J Mol Biol. 2017;429:128-141 pubmed publisher
    ..its IPV motifs to interact with sHsps, including Hsp27 (HspB1), ?B-crystallin (HspB5), Hsp22 (HspB8), and Hsp20 (HspB6)...
  62. Muthusamy S, Dalal M, Chinnusamy V, Bansal K. Genome-wide identification and analysis of biotic and abiotic stress regulation of small heat shock protein (HSP20) family genes in bread wheat. J Plant Physiol. 2017;211:100-113 pubmed publisher
    Small Heat Shock Proteins (sHSPs)/HSP20 are molecular chaperones that protect plants by preventing protein aggregation during abiotic stress conditions, especially heat stress...
  63. Matsushima Nishiwaki R, Toyoda H, Takamatsu R, Yasuda E, Okuda S, Maeda A, et al. Heat shock protein 22 (HSPB8) reduces the migration of hepatocellular carcinoma cells through the suppression of the phosphoinositide 3-kinase (PI3K)/AKT pathway. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1629-1639 pubmed publisher
    Small heat shock proteins (HSPs) regulate a variety of cell functions. Among them, HSP22 and HSP20 are recognized to be ubiquitously expressed in various tissues...
  64. Zhao P, Wang D, Wang R, Kong N, Zhang C, Yang C, et al. Genome-wide analysis of the potato Hsp20 gene family: identification, genomic organization and expression profiles in response to heat stress. BMC Genomics. 2018;19:61 pubmed publisher
    Heat shock proteins (Hsps) are essential components in plant tolerance mechanism under various abiotic stresses. Hsp20 is the major family of heat shock proteins, but little of Hsp20 family is known in potato (Solanum tuberosum), which ..
  65. Zhang C, Qu S, Wei X, Feng Y, Zhu H, Deng J, et al. HSP25 down-regulation enhanced p53 acetylation by dissociation of SIRT1 from p53 in doxorubicin-induced H9c2 cell apoptosis. Cell Stress Chaperones. 2016;21:251-60 pubmed publisher
    ..Subsequent studies found that HSP25, but not HSP90, HSP70, and HSP20, interacted with SIRT1...
  66. Lim H, Kim B, Hwang I, Lee J, Choi I, Kim Y, et al. Thermal stress induces a distinct transcriptome profile in the Pacific oyster Crassostrea gigas. Comp Biochem Physiol Part D Genomics Proteomics. 2016;19:62-70 pubmed publisher
    ..g. ribosomal protein genes), were repressed. In particular, several hsp70 isoforms and a small hsp20 maintained prolonged mRNA expressions for 72h...
  67. Weeks S, Muranova L, Heirbaut M, Beelen S, Strelkov S, Gusev N. Characterization of human small heat shock protein HSPB1 α-crystallin domain localized mutants associated with hereditary motor neuron diseases. Sci Rep. 2018;8:688 pubmed publisher
    ..Specific differences are observed in the ability to form hetero-oligomers with the homologue HSPB6 (HSP20)...
  68. Zhu Z, Reiser G. The small heat shock proteins, especially HspB4 and HspB5 are promising protectants in neurodegenerative diseases. Neurochem Int. 2018;115:69-79 pubmed publisher
    ..Currently, 11 members of this family have been classified, namely HspB1 to HspB11. HspB1, HspB2, HspB5, HspB6, HspB7, and HspB8, which are expressed in brain have been observed to be related to the pathology of ..
  69. Gagaoua M, Terlouw E, Boudjellal A, Picard B. Coherent correlation networks among protein biomarkers of beef tenderness: What they reveal. J Proteomics. 2015;128:365-74 pubmed publisher
    ..For the two muscles of the three breeds, DJ-1 and Peroxiredoxin 6 were consistently correlated with Hsp20 and μ-calpain, respectively. For the three breeds, μ-calpain was related to Hsp70-8 in the LT muscle...
  70. Kwon S, Kim S, Song N, Chang S, Hwang Y, Yang D, et al. Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1. J Nutr Biochem. 2016;30:24-32 pubmed publisher
    ..heat shock proteins (Hsp) 40 (Dnajb1) and Hsp90 (Hsp90b1), but not those of other heat shock proteins including Hsp20, Hsp27, Hsp47, Hsp70, Hsp72, and Hsp90, and another type of Hsp40 (Dnaja1)...
  71. Yusof N, Hashim N, Beddoe T, Mahadi N, Illias R, Bakar F, et al. Thermotolerance and molecular chaperone function of an SGT1-like protein from the psychrophilic yeast, Glaciozyma antarctica. Cell Stress Chaperones. 2016;21:707-15 pubmed publisher
    ..We isolated a G. antarctica homologue of small heat shock protein 20 (HSP20), GaSGT1, and observed that the GaSGT1 mRNA expression in G...
  72. He F, Shi E, Yan L, Li J, Jiang X. Inhibition of micro-ribonucleic acid-320 attenuates neurologic injuries after spinal cord ischemia. J Thorac Cardiovasc Surg. 2015;150:398-406 pubmed publisher
    ..In parallel experiments, expressions of miR-320, and the phosphorylation state of heat-shock protein 20 (phospho-Hsp20) in the spinal cord were evaluated by quantitative real-time polymerase chain reaction and western blot analysis...
  73. Olguín N, Champomier Vergès M, Anglade P, Baraige F, Cordero Otero R, Bordons A, et al. Transcriptomic and proteomic analysis of Oenococcus oeni PSU-1 response to ethanol shock. Food Microbiol. 2015;51:87-95 pubmed publisher
    ..observed that some genes were over-expressed in response to ethanol stress (for example, the heat shock protein Hsp20 and a dipeptidase). Proteomic analysis showed that several proteins are affected by the presence of ethanol...
  74. Kathy Lee S, Yoon K, Park J, Kim H, Woo J, Lee S, et al. Additional Effects of Back-Shu Electroacupuncture and Moxibustion in Cardioprotection of Rat Ischemia-Reperfusion Injury. Evid Based Complement Alternat Med. 2015;2015:625645 pubmed publisher
    ..In addition, HSP20 and HSP27 were expressed significantly more in the treatment groups...
  75. Kumar R, Gupta I, Verma A, Kumari R, Verma N. Molecular characterization and SNP identification in HSPB6 gene in Karan Fries (Bos taurus x Bos indicus) cattle. Trop Anim Health Prod. 2017;49:1059-1063 pubmed publisher
    ..The present study was undertaken for molecular characterization and detection of genetic polymorphisms of HSPB6 gene in 100 Karan Fries Cattle...
  76. van Doorn R, Slieker R, Boonk S, Zoutman W, Goeman J, Bagot M, et al. Epigenomic Analysis of Sézary Syndrome Defines Patterns of Aberrant DNA Methylation and Identifies Diagnostic Markers. J Invest Dermatol. 2016;136:1876-1884 pubmed publisher
    ..Validation in an independent sample set showed promoter hypermethylation of CMTM2, C2orf40, G0S2, HSPB6, PROM1, and PAM in 94-100% of Sz samples but not in EID samples...
  77. Lai P, Tribe R, Johnson M. Differential impact of acute and prolonged cAMP agonist exposure on protein kinase A activation and human myometrium contractile activity. J Physiol. 2016;594:6369-6393 pubmed publisher
    ..to determine the relationship between myometrial contractility (spontaneous and oxytocin-induced), PKA activity, HSP20 phosphorylation and expression of contraction-associated and cAMP signalling proteins...
  78. Karolczak Bayatti M, Sweeney M, Cheng J, Edey L, Robson S, Ulrich S, et al. Acetylation of heat shock protein 20 (Hsp20) regulates human myometrial activity. J Biol Chem. 2011;286:34346-55 pubmed publisher
    Phosphorylation of heat shock protein 20 (Hsp20) by protein kinase A (PKA) is now recognized as an important regulatory mechanism modulating contractile activity in the human myometrium...
  79. Liu G, Zhu H, Cai W, Wang X, Jiang M, Essandoh K, et al. Regulation of BECN1-Mediated Autophagy by HSPB6: Insights from A Human HSPB6S10F Mutant. Autophagy. 2017;:1-56 pubmed publisher
    HSPB6/Hsp20 (heat shock protein family B [small] member 6) has emerged as a novel cardioprotector against stress-induced injury...
  80. Kato K, Goto S, Inaguma Y, Hasegawa K, Morishita R, Asano T. Purification and characterization of a 20-kDa protein that is highly homologous to alpha B crystallin. J Biol Chem. 1994;269:15302-9 pubmed
    ..These results suggest that p20 is related to stress proteins. ..
  81. Fontaine J, Sun X, Benndorf R, Welsh M. Interactions of HSP22 (HSPB8) with HSP20, alphaB-crystallin, and HSPB3. Biochem Biophys Res Commun. 2005;337:1006-11 pubmed
    ..we now show that HSP22 also can interact with two additional members of the sHSP family, alphaB-crystallin and HSP20. We also show that HSP22 is found in HPLC fractions of primate cardiac muscle containing high molecular weight ..
  82. Nefedova V, Sudnitsyna M, Strelkov S, Gusev N. Structure and properties of G84R and L99M mutants of human small heat shock protein HspB1 correlating with motor neuropathy. Arch Biochem Biophys. 2013;538:16-24 pubmed publisher
    ..Both mutants weakly interact with HspB6 forming small heterooligomers and being unable to form large heterooligomers characteristic for the wild type ..
  83. Qiao N, Zhu Y, Li H, Qu Z, Xiao Z. Expression of heat shock protein 20 inversely correlated with tumor progression in patients with ovarian cancer. Eur J Gynaecol Oncol. 2014;35:576-9 pubmed
    To investigate a possible correlation between expression levels of heat shock protein 20 (HSP20) and tumor progression in patients with ovarian cancer...
  84. Matsushima Nishiwaki R, Toyoda H, Nagasawa T, Yasuda E, Chiba N, Okuda S, et al. Phosphorylated Heat Shock Protein 20 (HSPB6) Regulates Transforming Growth Factor-α-Induced Migration and Invasion of Hepatocellular Carcinoma Cells. PLoS ONE. 2016;11:e0151907 pubmed publisher
    ..We previously reported that protein levels of a small HSP, HSP20 (HSPB6), decrease in vascular invasion positive HCC compared with those in the negative vascular invasion...
  85. Zhang L, Zhang Q, Wang X, Yang X, Li X, Yuan M. Selection of reference genes for qRT-PCR and expression analysis of high-altitude-related genes in grassland caterpillars (Lepidoptera: Erebidae: Gynaephora) along an altitude gradient. Ecol Evol. 2017;7:9054-9065 pubmed publisher
    ..Additionally, the expression patterns of four other genes (GPI,HIF1A,HSP20, and USP) associated with adaptation to extreme environments were assessed to explore the adaptive ..
  86. Fuchs M, Poirier D, Seguin S, Lambert H, Carra S, Charette S, et al. Identification of the key structural motifs involved in HspB8/HspB6-Bag3 interaction. Biochem J. 2009;425:245-55 pubmed publisher
    ..In addition, we show that Bag3 can bind to the molecular chaperone HspB6. The interaction between HspB6 and Bag3 requires the same regions that are involved in the HspB8-Bag3 association ..
  87. Ke L, Meijering R, Hoogstra Berends F, Mackovicova K, Vos M, Van Gelder I, et al. HSPB1, HSPB6, HSPB7 and HSPB8 protect against RhoA GTPase-induced remodeling in tachypaced atrial myocytes. PLoS ONE. 2011;6:e20395 pubmed publisher
    ..In addition to HSPB1, also overexpression of HSPB6, HSPB7 and HSPB8 protected against tachypacing-induced CaT reduction...
  88. Ju Y, Kwag S, Park H, Jung E, Jeong C, Jeong S, et al. Decreased expression of heat shock protein 20 in colorectal cancer and its implication in tumorigenesis. J Cell Biochem. 2015;116:277-86 pubmed publisher
    Heat shock protein 20 (HSP20), which is a member of the small heat shock protein family, is known to participate in many pathological processes, such as asthma, intimal hyperplasia, and insulin resistance...
  89. Yang M, Zhang Y, Zhang H, Wang H, Wei T, Che S, et al. Identification of MsHsp20 Gene Family in Malus sieversii and Functional Characterization of MsHsp16.9 in Heat Tolerance. Front Plant Sci. 2017;8:1761 pubmed publisher
    ..In this study, 12 putative M. sieversii Hsp20 genes were identified from RNA-Seq data and analyzed in terms of gene structure and phylogenetic relationships...
  90. Fuchs L, Giulumian A, Knoepp L, Pipkin W, Dickinson M, Hayles C, et al. Stress causes decrease in vascular relaxation linked with altered phosphorylation of heat shock proteins. Am J Physiol Regul Integr Comp Physiol. 2000;279:R492-8 pubmed
    ..vascular relaxation is associated with increases in the phosphorylation of a small heat shock protein (HSP), HSP20. An increase in phosphorylation of another small HSP, HSP27, is associated with impaired cyclic nucleotide-..
  91. Koga Y, Pelizzola M, Cheng E, Krauthammer M, Sznol M, Ariyan S, et al. Genome-wide screen of promoter methylation identifies novel markers in melanoma. Genome Res. 2009;19:1462-70 pubmed publisher
    ..05). Promoter methylation and differential gene expression of five markers (COL1A2, NPM2, HSPB6, DDIT4L, MT1G) were validated by sequencing of bisulfite-modified DNA and real-time reverse transcriptase PCR, ..
  92. Bruinsma I, Bruggink K, Kinast K, Versleijen A, Segers Nolten I, Subramaniam V, et al. Inhibition of ?-synuclein aggregation by small heat shock proteins. Proteins. 2011;79:2956-67 pubmed publisher
    ..Therefore, we investigated if the sHsps ?B-crystallin, Hsp27, Hsp20, HspB8, and HspB2B3 bind to ?-syn and affect ?-syn aggregation...