Hsp70

Summary

Gene Symbol: Hsp70
Description: heat shock protein family A (Hsp70) member 1A
Alias: HEL-S-103, HSP70-1, HSP70-1A, HSP70.1, HSP70I, HSP72, HSPA1, heat shock 70 kDa protein 1A, HSP70-1/HSP70-2, HSP70.1/HSP70.2, dnaK-type molecular chaperone HSP70-1, epididymis secretory protein Li 103, heat shock 70 kDa protein 1, heat shock 70 kDa protein 1/2, heat shock 70 kDa protein 1A/1B, heat shock 70kD protein 1A, heat shock 70kDa protein 1A, heat shock-induced protein
Species: human
Products:     Hsp70

Top Publications

  1. Selkirk G, McLellan T, Wright H, Rhind S. Expression of intracellular cytokines, HSP72, and apoptosis in monocyte subsets during exertional heat stress in trained and untrained individuals. Am J Physiol Regul Integr Comp Physiol. 2009;296:R575-86 pubmed publisher
    ..were analyzed for cytokines (TNF-alpha, IL-1beta, IL-6, IL-1ra, and IL-10) in CD14(++)CD16(-)/CD14(+)CD16(+) and HSP72/apoptosis in CD14(Bri)/CD14(Dim) subsets. In addition, serum levels of extracellular (e)HSP72 were also examined...
  2. Broquet A, Thomas G, Masliah J, Trugnan G, Bachelet M. Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release. J Biol Chem. 2003;278:21601-6 pubmed
    Accumulating evidence suggests that some heat shock proteins (Hsps), in particular the 72-kDa inducible Hsp70, associate to the cell membrane and might be secreted through an unknown mechanism to exert important functions in the immune ..
  3. Wang Y, Zhou F, Wu Y, Xu D, Li W, Liang S. The relationship between three heat shock protein 70 gene polymorphisms and susceptibility to lung cancer. Clin Chem Lab Med. 2010;48:1657-63 pubmed publisher
    Heat shock protein 70 (Hsp70) has been shown to act as a chaperone and be associated with a variety of tumors...
  4. Hageman J, van Waarde M, Zylicz A, Walerych D, Kampinga H. The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities. Biochem J. 2011;435:127-42 pubmed publisher
  5. Gurer C, Cimarelli A, Luban J. Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. J Virol. 2002;76:4666-70 pubmed
    ..cyclophilin A, we probed purified virions with antibodies against heat shock proteins Hsp27, Hsp40, Hsp60, Hsp70, Hsc70, and Hsp90...
  6. Temple S, Cheong K, Ardlie K, Sayer D, Waterer G. The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B. Intensive Care Med. 2004;30:1761-7 pubmed
    ..This suggests that HSPA1B-179C>T affects HSP70 production and is a key determinant of individual susceptibility to a variety of infectious and inflammatory ..
  7. Li J, Niu W, Qi Y, Mayila W, Zhu P, Muhuyati -, et al. Interactive association of heat shock protein 70 genes variants with natural longevity in Xinjiang Hetian Uygur ethnicity. Transl Res. 2009;154:257-64 pubmed publisher
    ..association of 3 variants (A1267G in HSPA1B, G190C in HSPA1A, and T2437C in HSPA1L) in the heat shock protein 70 (Hsp70) family with natural longevity in a Xinjiang Hetian Uygur population...
  8. Jinwal U, Akoury E, Abisambra J, O Leary J, Thompson A, Blair L, et al. Imbalance of Hsp70 family variants fosters tau accumulation. FASEB J. 2013;27:1450-9 pubmed publisher
    ..in a tetracycline (Tet)-based protein chase model, constitutive heat shock cognate 70 (Hsc70) and inducible Hsp72 slowed or accelerated tau clearance, respectively...
  9. Pae C, Mandelli L, Serretti A, Patkar A, Kim J, Lee C, et al. Heat-shock protein-70 genes and response to antidepressants in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:1006-11 pubmed
    ..In conclusion, genetic variants within the genes coding for HSP-70 family proteins may affect the action of antidepressants and thus their therapeutic efficacy. ..

More Information

Publications73

  1. Spagnolo P, Sato H, Marshall S, Antoniou K, Ahmad T, Wells A, et al. Association between heat shock protein 70/Hom genetic polymorphisms and uveitis in patients with sarcoidosis. Invest Ophthalmol Vis Sci. 2007;48:3019-25 pubmed
    ..b>HSP70 molecules play a key role in the immune response by functioning both as chaperones and as inducers of ..
  2. Konings A, Van Laer L, Michel S, Pawelczyk M, Carlsson P, Bondeson M, et al. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. Eur J Hum Genet. 2009;17:329-35 pubmed publisher
    ..This protection is highly variable between individuals. An association of HSP70 genes with NIHL has been described by Yang et al (2006) in a Chinese sample set of noise-exposed workers...
  3. Kotoglou P, Kalaitzakis A, Vezyraki P, Tzavaras T, Michalis L, Dantzer F, et al. Hsp70 translocates to the nuclei and nucleoli, binds to XRCC1 and PARP-1, and protects HeLa cells from single-strand DNA breaks. Cell Stress Chaperones. 2009;14:391-406 pubmed publisher
    For many years, there has been uncertainty concerning the reason for Hsp70 translocation to the nucleus and nucleolus...
  4. Goate A, Cooper D, Hall C, Leung T, Solomon E, Lim L. Localization of a human heat-shock HSP 70 gene sequence to chromosome 6 and detection of two other loci by somatic-cell hybrid and restriction fragment length polymorphism analysis. Hum Genet. 1987;75:123-8 pubmed
  5. Partida Rodríguez O, Torres J, Flores Luna L, Camorlinga M, Nieves Ramírez M, Lazcano E, et al. Polymorphisms in TNF and HSP-70 show a significant association with gastric cancer and duodenal ulcer. Int J Cancer. 2010;126:1861-1868 pubmed publisher
    Tumour Necrosis Factor (TNF) and Heat Shock Protein 70 (HSP70) are important molecules in inflammatory, infectious and tumoral processes...
  6. Ucisik Akkaya E, Davis C, Gorodezky C, Alaez C, Dorak M. HLA complex-linked heat shock protein genes and childhood acute lymphoblastic leukemia susceptibility. Cell Stress Chaperones. 2010;15:475-85 pubmed publisher
    Three heat shock protein 70 (HSP70) genes, HSPA1L, HSPA1A, and HSPA1B, are located within the human leukocyte antigen (HLA) class III region. HSPs act as stress signals and regulate natural killer cell response to cancer...
  7. Lancaster G, Møller K, Nielsen B, Secher N, Febbraio M, Nybo L. Exercise induces the release of heat shock protein 72 from the human brain in vivo. Cell Stress Chaperones. 2004;9:276-80 pubmed
    ..hypothesis that in response to physical stress the human brain has the capacity to release heat shock protein 72 (Hsp72) in vivo...
  8. Wang X, Wang Q, Guo L, Ying X, Zhao Y. Immunolocalisation of heat shock protein 72 and glycoprotein 96 in colonic adenocarcinoma. Acta Histochem. 2008;110:117-23 pubmed
    Heat shock protein 72 (HSP72) and glycoprotein 96 (gp96) are highly expressed in cancer tissues...
  9. He M, Guo H, Yang X, Zhang X, Zhou L, Cheng L, et al. Functional SNPs in HSPA1A gene predict risk of coronary heart disease. PLoS ONE. 2009;4:e4851 pubmed publisher
    b>HSP70 plays crucial roles in endothelial cell apoptosis, which is involved in the early phase and progress of coronary heart disease (CHD)...
  10. Gupta A, Cooper Z, Tulapurkar M, Potla R, Maity T, Hasday J, et al. Toll-like receptor agonists and febrile range hyperthermia synergize to induce heat shock protein 70 expression and extracellular release. J Biol Chem. 2013;288:2756-66 pubmed publisher
    Heat shock protein (Hsp) 70 expression can be stimulated by febrile range temperature (FRT). Hsp70 has been shown to be elevated in serum of patients with sepsis, and when released from cells, extracellular Hsp70 exerts endotoxin-like ..
  11. Donnelly B, Needham P, Snyder A, Roy A, Khadem S, Brodsky J, et al. Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis. J Biol Chem. 2013;288:13124-35 pubmed publisher
    ..of NCC immunoprecipitates revealed that the cotransporter formed complexes with the core chaperones Hsp90, Hsp70, and Hsp40. Disruption of Hsp90 function accelerated NCC degradation, suggesting that Hsp90 promotes NCC folding...
  12. Liu H, Vuyyuru V, Pham C, Yang Y, Singh B. Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association. Oncogene. 1999;18:3461-70 pubmed
    ..We provide evidence that mouse c-Mos binds to Hsp70, a molecular chaperone. Hsp70 was found to associate with Mos ectopically expressed in COS-1 cells...
  13. Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A. HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction. PLoS Biol. 2010;8:e1000410 pubmed publisher
    ..Enhanced expression of Hsp72 has been shown to reduce tissue injury in response to stress stimuli and improve cell survival in experimental ..
  14. Sargent C, Dunham I, Trowsdale J, Campbell R. Human major histocompatibility complex contains genes for the major heat shock protein HSP70. Proc Natl Acad Sci U S A. 1989;86:1968-72 pubmed
    ..for the presence of additional loci, we have located a duplicated locus encoding the major heat shock protein HSP70 between the complement and tumor necrosis factor genes...
  15. Saleh A, Srinivasula S, Balkir L, Robbins P, Alnemri E. Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000;2:476-83 pubmed
    ..Here we show that the documented anti-apoptotic effect of the principal heat-shock protein, Hsp70, is mediated through its direct association with the caspase-recruitment domain (CARD) of Apaf-1 and through ..
  16. Vargas Alarcon G, Londoño J, Hernandez Pacheco G, Gamboa R, Castillo E, Pacheco Tena C, et al. Heat shock protein 70 gene polymorphisms in Mexican patients with spondyloarthropathies. Ann Rheum Dis. 2002;61:48-51 pubmed
    To investigate the role of HSP70 genes as contributors to genetic susceptibility of the spondyloarthropathies (SpA) in the Mexican population...
  17. Gao X, Zhou C, Zhou Z, Wu M, Cao C, Hu H. The C-terminal helices of heat shock protein 70 are essential for J-domain binding and ATPase activation. J Biol Chem. 2012;287:6044-52 pubmed publisher
    The J-domain co-chaperones work together with the heat shock protein 70 (HSP70) chaperone to regulate many cellular events, but the mechanism underlying the J-domain-mediated HSP70 function remains elusive...
  18. Voss K, Combs B, Patterson K, Binder L, Gamblin T. Hsp70 alters tau function and aggregation in an isoform specific manner. Biochemistry. 2012;51:888-98 pubmed publisher
    ..Chaperones of the heat shock protein 70 (Hsp70) family have been implicated in the prevention of abnormal tau aggregation in adult neurons...
  19. Singh R, Kølvraa S, Bross P, Christensen K, Bathum L, Gregersen N, et al. Anti-inflammatory heat shock protein 70 genes are positively associated with human survival. Curr Pharm Des. 2010;16:796-801 pubmed
    ..The involvement of heat shock protein 70 (Hsp70) in cellular maintenance and repair mechanisms, including its role as an anti-inflammatory protein, makes it a ..
  20. Gabai V, Budagova K, Sherman M. Increased expression of the major heat shock protein Hsp72 in human prostate carcinoma cells is dispensable for their viability but confers resistance to a variety of anticancer agents. Oncogene. 2005;24:3328-38 pubmed
    The major heat shock protein Hsp72 is expressed at high levels in various types of cancer...
  21. Iordanskiy S, Zhao Y, DiMarzio P, Agostini I, Dubrovsky L, Bukrinsky M. Heat-shock protein 70 exerts opposing effects on Vpr-dependent and Vpr-independent HIV-1 replication in macrophages. Blood. 2004;104:1867-72 pubmed
    ..In this report, we demonstrate that Hsp70, a heat-shock protein contributing to cellular stress responses, inhibits nuclear translocation of HIV-1 Vpr...
  22. Michels A, Kanon B, Bensaude O, Kampinga H. Heat shock protein (Hsp) 40 mutants inhibit Hsp70 in mammalian cells. J Biol Chem. 1999;274:36757-63 pubmed
    ..H. (1997) J. Biol. Chem. 272, 33283-33289). We now provide further evidence for a functional interaction between Hsp70 and the J-domain of Hsp40 with denatured luciferase resulting in reactivation of heat-denatured luciferase within ..
  23. Kawaguchi S, Hagiwara A, Suzuki M. Polymorphic analysis of the heat-shock protein 70 gene (HSPA1A) in Ménière's disease. Acta Otolaryngol. 2008;128:1173-7 pubmed publisher
    The single nucleotide polymorphism (SNP) 190 G/C in HSP70-1 (HSPA1A) was found to be a factor associated with Meniere's disease (MD)...
  24. Li J, Tang B, Sun H, Feng M, Cheng Z, Niu W. Interacting contribution of the five polymorphisms in three genes of Hsp70 family to essential hypertension in Uygur ethnicity. Cell Stress Chaperones. 2009;14:355-62 pubmed publisher
    Experimental evidence suggesting that heat shock protein 70 (Hsp70) gene or associated genes are responsible for the pathophysiology of hypertension is accumulating...
  25. Abboud P, Lahni P, Page K, Giuliano J, Harmon K, Dunsmore K, et al. The role of endogenously produced extracellular hsp72 in mononuclear cell reprogramming. Shock. 2008;30:285-92 pubmed publisher
    Intracellular heat shock protein 72 (Hsp72) is known to serve a broad cytoprotective role...
  26. Milner C, Campbell R. Structure and expression of the three MHC-linked HSP70 genes. Immunogenetics. 1990;32:242-51 pubmed
    A duplicated locus encoding the major heat shock-induced protein HSP70 is located in the major histocompatibility complex (MHC) class III region 92 kilobases (kb) telomeric to the C2 gene...
  27. Chow A, Steel R, Anderson R. Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis. Cell Stress Chaperones. 2009;14:253-63 pubmed publisher
    In addition to its role as a molecular chaperone, heat shock protein 72 (Hsp72) protects cells against a wide range of apoptosis inducing stresses...
  28. Hurwitz M, Kaur P, Nagaraja G, Bausero M, Manola J, Asea A. Radiation therapy induces circulating serum Hsp72 in patients with prostate cancer. Radiother Oncol. 2010;95:350-8 pubmed publisher
    b>Hsp72 found in the extracellular milieu has been shown to play an important role in immune regulation. The impact of common cancer therapies on extracellular release of Hsp72 however, has been to date undefined...
  29. Qi Y, Niu W, Zhu T, Liu J, Dong W, Xu Y, et al. Genetic interaction of Hsp70 family genes polymorphisms with high-altitude pulmonary edema among Chinese railway constructors at altitudes exceeding 4000 meters. Clin Chim Acta. 2009;405:17-22 pubmed publisher
    ..polymorphisms within HSPA1A (rs1043618 and rs1008438), HSPA1B (rs1061581 and rs539689) and HSPA1L (rs2227956) of Hsp70 family to explore their potential interaction upon susceptibility to HAPE in Chinese...
  30. Shi Y, Mosser D, Morimoto R. Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev. 1998;12:654-66 pubmed
    ..These events coincide with elevated levels of Hsp70 and other heat shock proteins (molecular chaperones)...
  31. Powers M, Clarke P, Workman P. Dual targeting of HSC70 and HSP72 inhibits HSP90 function and induces tumor-specific apoptosis. Cancer Cell. 2008;14:250-62 pubmed publisher
    Heat-shock protein 70 (HSP70) isoforms contribute to tumorigenesis through their well-documented antiapoptotic activity and via their role as cochaperones for the HSP90 molecular chaperone...
  32. Osipiuk J, Walsh M, Freeman B, Morimoto R, Joachimiak A. Structure of a new crystal form of human Hsp70 ATPase domain. Acta Crystallogr D Biol Crystallogr. 1999;55:1105-7 pubmed
    b>Hsp70 proteins are highly conserved proteins induced by heat shock and other stress conditions. An ATP-binding domain of human Hsp70 protein has been crystallized in two major morphological forms at pH 7...
  33. Alfirevic A, Mills T, Harrington P, Pinel T, Sherwood J, Jawaid A, et al. Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006;16:287-96 pubmed
    ..The heat shock protein (HSP70) gene cluster is located in the MHC class III region...
  34. Stankiewicz A, Lachapelle G, Foo C, Radicioni S, Mosser D. Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. J Biol Chem. 2005;280:38729-39 pubmed
    b>Hsp70 overexpression can protect cells from stress-induced apoptosis. Our previous observation that Hsp70 inhibits cytochrome c release in heat-stressed cells led us to examine events occurring upstream of mitochondrial disruption...
  35. Wu Y, Wang C, Chen C, Hsu Y, Lin S, Lin Y, et al. Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease. Hum Genet. 2004;114:236-41 pubmed
    ..of polymorphisms -110 A/C, +190 G/C, +1267 A/G, +2074 G/C, and +2437 G/C in the 5' and coding regions of the HSP70-1, HSP70-2, and HSP70-hom genes with the risk of PD by screening DNA samples from 274 PD patients and 183 controls ..
  36. Yamada P, Amorim F, Moseley P, Schneider S. Heat shock protein 72 response to exercise in humans. Sports Med. 2008;38:715-33 pubmed
    ..e. skeletal muscle vs lymphocyte) and the origin of the sample (i.e. venous vs arterial serum). Collectively, the reviewed studies reveal exciting and novel research that encourages future investigation in this area. ..
  37. Singh R, Kølvraa S, Bross P, Christensen K, Gregersen N, Tan Q, et al. Heat-shock protein 70 genes and human longevity: a view from Denmark. Ann N Y Acad Sci. 2006;1067:301-8 pubmed
    We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat-shock protein) genes on 6p21 with human longevity...
  38. Clemons N, Buzzard K, Steel R, Anderson R. Hsp72 inhibits Fas-mediated apoptosis upstream of the mitochondria in type II cells. J Biol Chem. 2005;280:9005-12 pubmed
    Heat shock protein 72 (Hsp72) inhibits apoptosis induced by some stresses that trigger the intrinsic apoptosis pathway...
  39. Iordanskiy S, Zhao Y, Dubrovsky L, Iordanskaya T, Chen M, Liang D, et al. Heat shock protein 70 protects cells from cell cycle arrest and apoptosis induced by human immunodeficiency virus type 1 viral protein R. J Virol. 2004;78:9697-704 pubmed
    ..A screening for multicopy suppressors of these Vpr activities in fission yeast identified heat shock protein 70 (Hsp70) as a suppressor of Vpr-induced cell cycle arrest...
  40. Young J, Hoogenraad N, Hartl F. Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70. Cell. 2003;112:41-50 pubmed
    ..Here, we show that in mammals, the cytosolic chaperones Hsp90 and Hsp70 dock onto a specialized TPR domain in the import receptor Tom70 at the outer mitochondrial membrane...
  41. Scheufler C, Brinker A, Bourenkov G, Pegoraro S, Moroder L, Bartunik H, et al. Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine. Cell. 2000;101:199-210 pubmed
    The adaptor protein Hop mediates the association of the molecular chaperones Hsp70 and Hsp90...
  42. Ravagnan L, Gurbuxani S, Susin S, Maisse C, Daugas E, Zamzami N, et al. Heat-shock protein 70 antagonizes apoptosis-inducing factor. Nat Cell Biol. 2001;3:839-43 pubmed
    Heat-shock protein 70 (Hsp70) has been reported to block apoptosis by binding apoptosis protease activating factor-1 (Apaf-1), thereby preventing constitution of the apoptosome, the Apaf-1/cytochrome c/caspase-9 activation complex [1,2]...
  43. Pae C, Kim T, Kwon O, Artioli P, Serretti A, Lee C, et al. Polymorphisms of heat shock protein 70 gene (HSPA1A, HSPA1B and HSPA1L) and schizophrenia. Neurosci Res. 2005;53:8-13 pubmed
    The heat shock protein 70 (HSP70) is believed to be involved in the pathogenesis of schizophrenia with regards to neurodevelopment...
  44. Dedmon M, Christodoulou J, Wilson M, Dobson C. Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species. J Biol Chem. 2005;280:14733-40 pubmed
    ..Moreover, our studies reveal that Hsp70 alters the characteristics of toxic alphaSyn aggregates and indicate that cellular toxicity arises from the ..
  45. Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C. BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72. Int J Mol Sci. 2016;18: pubmed publisher
    ..Here, we examined the functional correlation of HSP72, CHIP, and BAG2, employing human primary fibroblasts...
  46. Rogers R, Morris E, Wheatley J, Archer A, McCoin C, White K, et al. Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease. Diabetes. 2016;65:3341-3351 pubmed
    ..The positive metabolic actions of heat shock protein 72 (HSP72), which include increased oxidative capacity and enhanced mitochondrial function, underlie the protective effects ..
  47. Gibson O, Turner G, Tuttle J, Taylor L, Watt P, Maxwell N. Heat acclimation attenuates physiological strain and the HSP72, but not HSP90α, mRNA response to acute normobaric hypoxia. J Appl Physiol (1985). 2015;119:889-99 pubmed publisher
    ..Hemoglobin mass did not change following HA nor CON. HSP72 and HSP90α mRNA increased in response to each HA session, but did not change with CON...
  48. Cheng L, Smith D, Anderson R, Nagley P. Modulation of cellular Hsp72 levels in undifferentiated and neuron-like SH-SY5Y cells determines resistance to staurosporine-induced apoptosis. PLoS ONE. 2011;6:e24473 pubmed publisher
    Increased expression of Hsp72 accompanies differentiation of human neuroblastoma SH-SY5Y cells to neuron-like cells...
  49. Kanouchi H, Kakimoto T, Nakano H, Suzuki M, Nakai Y, Shiozaki K, et al. The Brewed Rice Vinegar Kurozu Increases HSPA1A Expression and Ameliorates Cognitive Dysfunction in Aged P8 Mice. PLoS ONE. 2016;11:e0150796 pubmed publisher
    ..However, concentrated Kurozu could not increase HSPA1A expression in mouse primary neurons, suggesting it may not directly affect neurons. ..
  50. Dulin E, Garcia Barreno P, Guisasola M. Genetic variations of HSPA1A, the heat shock protein levels, and risk of atherosclerosis. Cell Stress Chaperones. 2012;17:507-16 pubmed publisher
    ..Given the antiatherogenic functions of intracellular HSPA1A, the -110A and +190 G alleles could constitute potential genetic biomarkers of a less severe clinical phenotype for the risk of developing atherosclerosis. ..
  51. Li D, Gao J, Yang Y, Sun L, Suo S, Luo Y, et al. CYLD coordinates with EB1 to regulate microtubule dynamics and cell migration. Cell Cycle. 2014;13:974-83 pubmed publisher
    ..These findings also support the notion that coordinated actions of microtubule-binding proteins are critical for microtubule-mediated cellular events. ..
  52. Zhang F, Zang T, Wilson S, Johnson M, Bieniasz P. Clathrin facilitates the morphogenesis of retrovirus particles. PLoS Pathog. 2011;7:e1002119 pubmed publisher
    ..We propose a model in which clathrin contributes to the spatial organization of Gag and Pol proteins, and thereby regulates proteolytic processing of virion components during particle assembly. ..
  53. Hernández M, Sullivan W, Toft D. The assembly and intermolecular properties of the hsp70-Hop-hsp90 molecular chaperone complex. J Biol Chem. 2002;277:38294-304 pubmed
    The highly coordinated interactions of several molecular chaperones, including hsp70 and hsp90, are required for the folding and conformational regulation of a variety of proteins in eukaryotic cells, such as steroid hormone receptors ..
  54. Gibson O, Mee J, Taylor L, Tuttle J, Watt P, Maxwell N. Isothermic and fixed-intensity heat acclimation methods elicit equal increases in Hsp72 mRNA. Scand J Med Sci Sports. 2015;25 Suppl 1:259-68 pubmed publisher
    Thermotolerance, to which heat shock protein-72 (Hsp72) contributes, is an acquired state achieved following heat acclimation (HA), eliciting cellular adaption and protection against thermal stress...
  55. Shevtsov M, Huile G, Multhoff G. Membrane heat shock protein 70: a theranostic target for cancer therapy. Philos Trans R Soc Lond B Biol Sci. 2018;373: pubmed publisher
    ..Heat shock protein 70 (HSP70), also termed HSPA1A, the major stress-inducible member of this family is overexpressed in a large variety of ..
  56. Yang S, Oh K, Park E, Chang H, Park J, Seong M, et al. USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate katanin-p60-mediated axonal growth. J Neurosci. 2013;33:12728-38 pubmed publisher
    ..Here we showed that USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate the stability of katanin-p60 and thereby axonal growth...
  57. Takayama S, Xie Z, Reed J. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem. 1999;274:781-6 pubmed
    Heat Shock Protein 70 kDa (Hsp70) family molecular chaperones play critical roles in protein folding and trafficking in all eukaryotic cells...
  58. Valen G, Kawakami T, Tähepõld P, Dumitrescu A, Löwbeer C, Vaage J. Glucocorticoid pretreatment protects cardiac function and induces cardiac heat shock protein 72. Am J Physiol Heart Circ Physiol. 2000;279:H836-43 pubmed
    ..and we hypothetized that this protection might be due to induction of the cardioprotective heat shock protein 72 (HSP72)...
  59. Xu H, Ito T, Tawada A, Maeda H, Yamanokuchi H, Isahara K, et al. Effect of hyaluronan oligosaccharides on the expression of heat shock protein 72. J Biol Chem. 2002;277:17308-14 pubmed
    ..intraarticular treatment with a hyaluronan (HA) preparation (840 kDa), HA84, up-regulates heat shock protein 72 (Hsp72) expression and suppresses degeneration of synovial cells in an arthritis model...
  60. Liu Q, D Silva P, Walter W, Marszalek J, Craig E. Regulated cycling of mitochondrial Hsp70 at the protein import channel. Science. 2003;300:139-41 pubmed
    b>Hsp70 of the mitochondrial matrix (mtHsp70) provides a critical driving force for the import of proteins into mitochondria. Tim44, a peripheral inner-membrane protein, tethers it to the import channel...
  61. Wang X, Zhou Y, Sun L, Chen W, Li X, Wang Q, et al. Complex formation between heat shock protein 72 and hepatitis B virus X protein in hepatocellular carcinoma tissues. J Proteome Res. 2008;7:5133-7 pubmed publisher
    ..Heat shock protein 72 (HSP72) as a molecular chaperone has been confirmed to overexpress in epithelial carcinoma cells...
  62. Fang C, Kuo H, Pan T, Yu F, Yih L. HSP70 regulates the function of mitotic centrosomes. Cell Mol Life Sci. 2016;73:3949-60 pubmed publisher
    ..Inhibition or depletion of HSP70 impaired the function of mitotic centrosome and disrupted MT nucleation and polymerization from the spindle pole, ..
  63. Soudry E, Stern Shavit S, Hardy B, Morgenstern S, Hadar T, Feinmesser R. Heat shock proteins HSP90, HSP70 and GRP78 expression in medullary thyroid carcinoma. Ann Diagn Pathol. 2017;26:52-56 pubmed publisher
    ..These findings, though preliminary imply that these proteins may have a role in medullary thyroid carcinoma's tumor biology and may have and future therapeutic options. Larger cohorts are needed to corroborate these results. ..
  64. Yoon H, Chan D, Reynolds A, Qin J, Wong J. N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso. Mol Cell. 2003;12:723-34 pubmed
    ..Thus, our data demonstrate a critical role for a methyl CpG binding protein in mediating DNA methylation-dependent repression and reveal the mechanism by which it represses transcription. ..