hsp60

Summary

Gene Symbol: hsp60
Description: heat shock protein family D (Hsp60) member 1
Alias: CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13, 60 kDa heat shock protein, mitochondrial, 60 kDa chaperonin, P60 lymphocyte protein, chaperonin 60, heat shock 60kDa protein 1 (chaperonin), heat shock protein 65, mitochondrial matrix protein P1, short heat shock protein 60 Hsp60s1
Species: human
Products:     hsp60

Top Publications

  1. Xanthoudakis S, Roy S, Rasper D, Hennessey T, Aubin Y, Cassady R, et al. Hsp60 accelerates the maturation of pro-caspase-3 by upstream activator proteases during apoptosis. EMBO J. 1999;18:2049-56 pubmed
    ..A biochemical analysis of the protein constituents of the activation complex showed that Hsp60 was also present...
  2. Chandra D, Choy G, Tang D. Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release: evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3. J Biol Chem. 2007;282:31289-301 pubmed
    Most heat shock proteins (HSPs) have pro-survival functions. However, the role of HSP60, a mitochondrial matrix protein, is somewhat controversial with both pro-survival and pro-apoptotic functions reported...
  3. Singh B, Patel H, Ridley R, Freeman K, Gupta R. Mitochondrial import of the human chaperonin (HSP60) protein. Biochem Biophys Res Commun. 1990;169:391-6 pubmed
    ..The cDNA for human hsp60 (synonyms: GroEL homolog, P1) was transcribed and translated in vitro and its import into isolated rat heart mitochondria examined...
  4. Xiao Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, et al. Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study. Stroke. 2005;36:2571-6 pubmed
    Previous work has shown that soluble heat shock protein 60 (HSP60; sHSP60), present in circulating blood, is associated with carotid atherosclerosis...
  5. Castilla C, Congregado B, Conde J, Medina R, Torrubia F, Japon M, et al. Immunohistochemical expression of Hsp60 correlates with tumor progression and hormone resistance in prostate cancer. Urology. 2010;76:1017.e1-6 pubmed publisher
    To investigate the expression of Hsp60 protein in prostate cancer biopsy samples, and its association with prognostic clinical parameters and hormone resistance and survival...
  6. Benagiano M, D Elios M, Amedei A, Azzurri A, van der Zee R, Ciervo A, et al. Human 60-kDa heat shock protein is a target autoantigen of T cells derived from atherosclerotic plaques. J Immunol. 2005;174:6509-17 pubmed
    ..This hypothesis is in agreement with the notion that immunization with HSP exacerbates atherosclerosis, whereas immunosuppression and T cell depletion prevent the formation of arteriosclerotic lesions in experimental animals. ..
  7. Hansen J, Bross P, Westergaard M, Nielsen M, Eiberg H, Børglum A, et al. Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter. Hum Genet. 2003;112:71-7 pubmed
    Although the mitochondrial chaperonin Hsp60 and its co-chaperonin Hsp10 have received great attention in the last decade, and it has been proposed that mutations and variations in these genes may be implicated in genetic diseases, the ..
  8. Lewthwaite J, Owen N, Coates A, Henderson B, Steptoe A. Circulating human heat shock protein 60 in the plasma of British civil servants: relationship to physiological and psychosocial stress. Circulation. 2002;106:196-201 pubmed
    ..Plasma was assayed for levels of Hsp60, tumor necrosis factor alpha (TNFalpha), C-reactive protein, von Willebrand factor, high density lipoprotein (HDL),..
  9. Kirchhoff S, Gupta S, Knowlton A. Cytosolic heat shock protein 60, apoptosis, and myocardial injury. Circulation. 2002;105:2899-904 pubmed
    ..key mitochondrial proteins in apoptosis and the known antiapoptotic effects of HSP27 and HSP72, we postulated that HSP60, primarily a mitochondrial protein, also exerts an antiapoptotic effect...

More Information

Publications76

  1. Barazi H, Zhou L, Templeton N, Krutzsch H, Roberts D. Identification of heat shock protein 60 as a molecular mediator of alpha 3 beta 1 integrin activation. Cancer Res. 2002;62:1541-8 pubmed
    ..The protein was identified as HSP60 using two-dimensional electrophoresis and mass spectrometry and confirmed by reimmunoprecipitation of the integrin ..
  2. Parnas A, Nadler M, Nisemblat S, Horovitz A, Mandel H, Azem A. The MitCHAP-60 disease is due to entropic destabilization of the human mitochondrial Hsp60 oligomer. J Biol Chem. 2009;284:28198-203 pubmed publisher
    ..The disease is caused by a point mutation at position 3 (D3G) of the mature mitochondrial Hsp60 protein, which renders it unable to complement the deletion of the homologous bacterial protein in Escherichia ..
  3. Chun J, Choi B, Lee K, Lee D, Kang D, Lee J, et al. Cytosolic Hsp60 is involved in the NF-kappaB-dependent survival of cancer cells via IKK regulation. PLoS ONE. 2010;5:e9422 pubmed publisher
    Cytoplasmic presence of Hsp60, which is principally a nuclear gene-encoded mitochondrial chaperonin, has frequently been stated, but its role in intracellular signaling is largely unknown...
  4. Ghosh J, Siegelin M, Dohi T, Altieri D. Heat shock protein 60 regulation of the mitochondrial permeability transition pore in tumor cells. Cancer Res. 2010;70:8988-93 pubmed publisher
    ..Here, we show that the molecular chaperone heat shock protein 60 (Hsp60) directly associates with cyclophilin D (CypD), a component of the mitochondrial permeability transition pore...
  5. Padwad Y, Mishra K, Jain M, Chanda S, Karan D, Ganju L. RNA interference mediated silencing of Hsp60 gene in human monocytic myeloma cell line U937 revealed decreased dengue virus multiplication. Immunobiology. 2009;214:422-9 pubmed publisher
    ..A significant expression of Hsp60 was observed in virally infected U937 cells as compared to controls...
  6. Kim Y, Koh J, Lee Y, Kim B, Lee S, Lee K, et al. Increased circulating heat shock protein 60 induced by menopause, stimulates apoptosis of osteoblast-lineage cells via up-regulation of toll-like receptors. Bone. 2009;45:68-76 pubmed publisher
    ..Previous studies have reported that the HSP60 stimulates osteoclast formation and bone resorption...
  7. Ikawa S, Weinberg R. An interaction between p21ras and heat shock protein hsp60, a chaperonin. Proc Natl Acad Sci U S A. 1992;89:2012-6 pubmed
    ..Nucleotide sequence analysis revealed that p60 is the murine heat shock protein hsp60, a chaperonin...
  8. Campanella C, Bucchieri F, Merendino A, Fucarino A, Burgio G, Corona D, et al. The odyssey of Hsp60 from tumor cells to other destinations includes plasma membrane-associated stages and Golgi and exosomal protein-trafficking modalities. PLoS ONE. 2012;7:e42008 pubmed publisher
    In a previous work we showed for the first time that human tumor cells secrete Hsp60 via exosomes, which are considered immunologically active microvesicles involved in tumor progression...
  9. Goh Y, Yap C, Huang B, Cronshaw A, Leung B, Lai P, et al. Heat-shock protein 60 translocates to the surface of apoptotic cells and differentiated megakaryocytes and stimulates phagocytosis. Cell Mol Life Sci. 2011;68:1581-92 pubmed publisher
    Heat-shock protein 60 (Hsp60) is a highly conserved stress protein which has chaperone functions in prokaryotes and mammalian cells...
  10. Cappello F, David S, Rappa F, Bucchieri F, Marasa L, Bartolotta T, et al. The expression of HSP60 and HSP10 in large bowel carcinomas with lymph node metastase. BMC Cancer. 2005;5:139 pubmed
    ..The objective of the present study was to evaluate the presence and expression of HSP60 and HSP10 in a series of large bowel carcinomas and locoregional lymph nodes with and without metastases...
  11. Osterloh A, Meier Stiegen F, Veit A, Fleischer B, von Bonin A, Breloer M. Lipopolysaccharide-free heat shock protein 60 activates T cells. J Biol Chem. 2004;279:47906-11 pubmed
    A possible function of eukaryotic heat shock protein 60 (Hsp60) as endogenous danger signal has been controversially discussed in the past...
  12. Richardson A, Schwager F, Landry S, Georgopoulos C. The importance of a mobile loop in regulating chaperonin/ co-chaperonin interaction: humans versus Escherichia coli. J Biol Chem. 2001;276:4981-7 pubmed
    ..While bacterial GroEL is functionally promiscuous with various co-chaperonin partners, its human homologue, Hsp60 functions specifically with its co-chaperonin partner, Hsp10, and not with other co-chaperonins, such as the ..
  13. Michaelsson J, Teixeira de Matos C, Achour A, Lanier L, Kärre K, Soderstrom K. A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition. J Exp Med. 2002;196:1403-14 pubmed
    ..we demonstrate that HLA-E also presents a peptide derived from the leader sequence of human heat shock protein 60 (hsp60)...
  14. Bozner P, Wilson G, Druzhyna N, Bryant Thomas T, LeDoux S, Wilson G, et al. Deficiency of chaperonin 60 in Down's syndrome. J Alzheimers Dis. 2002;4:479-86 pubmed
    ..stress response in DS, we discovered a defective basal expression of a major mitochondrial heat shock protein, chaperonin 60 (Cpn60) in non-transformed dermal fibroblast cell lines from DS individuals...
  15. Park S, Lee S, Jung G. Antisense oligodeoxynucleotides targeted against molecular chaperonin Hsp60 block human hepatitis B virus replication. J Biol Chem. 2003;278:39851-7 pubmed
    ..Therefore, HBV pol may require many assistance factors for its roles. Previous reports have shown that Hsp60, a molecular chaperone, activates HBV pol both in vitro and ex vivo, such as inside insect cells...
  16. Samali A, Cai J, Zhivotovsky B, Jones D, Orrenius S. Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells. EMBO J. 1999;18:2040-8 pubmed
    ..pro-caspase-3 is present in the mitochondrial fraction of Jurkat T cells in a complex with the chaperone proteins Hsp60 and Hsp10...
  17. Zhang X, He M, Cheng L, Chen Y, Zhou L, Zeng H, et al. Elevated heat shock protein 60 levels are associated with higher risk of coronary heart disease in Chinese. Circulation. 2008;118:2687-93 pubmed publisher
    Although heat shock protein 60 (Hsp60) is implicated in the pathogenesis of atherosclerosis, its role in coronary heart disease (CHD) is uncertain...
  18. Märker T, Sell H, Zillessen P, Glöde A, Kriebel J, Ouwens D, et al. Heat shock protein 60 as a mediator of adipose tissue inflammation and insulin resistance. Diabetes. 2012;61:615-25 pubmed publisher
    The stress protein heat shock protein 60 (Hsp60) induces secretion of proinflammatory mediators from murine adipocytes...
  19. Ellins E, Shamaei Tousi A, Steptoe A, Donald A, O Meagher S, Halcox J, et al. The relationship between carotid stiffness and circulating levels of heat shock protein 60 in middle-aged men and women. J Hypertens. 2008;26:2389-92 pubmed publisher
    ..In this study, we measured the association between plasma HSP60 and carotid arterial stiffness in middle-aged men and women...
  20. Cappello F, Tripodo C, Farina F, Franco V, Zummo G. HSP10 selective preference for myeloid and megakaryocytic precursors in normal human bone marrow. Eur J Histochem. 2004;48:261-5 pubmed
    ..It is known that they regulate gene expression, and cell proliferation, differentiation and death. HSP60 is a mitochondrial chaperonin, highly preserved during evolution, responsible of protein folding...
  21. Jindal S, Dudani A, Singh B, Harley C, Gupta R. Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen. Mol Cell Biol. 1989;9:2279-83 pubmed
    ..and an additional 20% conservative replacements) to the 65-kilodalton major antigen of mycobacteria, to the GroEL protein of Escherichia coli, and to the ribulose 1,5-bisphosphate carboxylase-oxygenase (rubisco) subunit binding ..
  22. Ghosh J, Dohi T, Kang B, Altieri D. Hsp60 regulation of tumor cell apoptosis. J Biol Chem. 2008;283:5188-94 pubmed
    ..cell cycle regulator and apoptosis inhibitor survivin as a novel protein associated with the molecular chaperone Hsp60. Acute ablation of Hsp60 by small interfering RNA destabilizes the mitochondrial pool of survivin, induces ..
  23. Merendino A, Bucchieri F, Campanella C, Marciano V, Ribbene A, David S, et al. Hsp60 is actively secreted by human tumor cells. PLoS ONE. 2010;5:e9247 pubmed publisher
    b>Hsp60, a Group I mitochondrial chaperonin, is classically considered an intracellular chaperone with residence in the mitochondria; nonetheless, in the last few years it has been found extracellularly as well as in the cell membrane...
  24. Lin L, Kim S, Wang Y, Gupta S, Davis B, Simon S, et al. HSP60 in heart failure: abnormal distribution and role in cardiac myocyte apoptosis. Am J Physiol Heart Circ Physiol. 2007;293:H2238-47 pubmed
    Heat shock protein (HSP) 60 is a mitochondrial and cytosolic protein. Previously, we reported that HSP60 doubled in end-stage heart failure, even though levels of the protective HSP72 were unchanged...
  25. Osterloh A, Kalinke U, Weiss S, Fleischer B, Breloer M. Synergistic and differential modulation of immune responses by Hsp60 and lipopolysaccharide. J Biol Chem. 2007;282:4669-80 pubmed
    ..In this study we show that Hsp60 mediates immune stimulation by different mechanisms, dependent and independent of lipopolysaccharide (LPS)...
  26. de Graaf R, Kloppenburg G, Kitslaar P, Bruggeman C, Stassen F. Human heat shock protein 60 stimulates vascular smooth muscle cell proliferation through Toll-like receptors 2 and 4. Microbes Infect. 2006;8:1859-65 pubmed
    ..receptors for exogenous pathogen-associated molecular patterns and have recently been thought to play a role in HSP60-induced cellular activation...
  27. Pignatelli D, Ferreira J, Soares P, Costa M, Magalhães M. Immunohistochemical study of heat shock proteins 27, 60 and 70 in the normal human adrenal and in adrenal tumors with suppressed ACTH production. Microsc Res Tech. 2003;61:315-23 pubmed
    ..HSP70 increases its levels in the cell in response to any stress and is induced by ACTH in the adrenal gland. HSP60 is located in the mitochondria and assists in the folding of mitochondrial peptides...
  28. Soltys B, Gupta R. Cell surface localization of the 60 kDa heat shock chaperonin protein (hsp60) in mammalian cells. Cell Biol Int. 1997;21:315-20 pubmed
    To investigate whether the 60-kDa heat shock chaperonin protein (hsp60) is present on the surface of mammalian cells, we used immunogold labeling of intact cells and backscattered electron imaging to image gold particles...
  29. Lebret T, Watson R, Molinie V, O Neill A, Gabriel C, Fitzpatrick J, et al. Heat shock proteins HSP27, HSP60, HSP70, and HSP90: expression in bladder carcinoma. Cancer. 2003;98:970-7 pubmed
    ..Expression levels of the 27-kilodalton HSP (HSP27), HSP60, HSP70, and HSP90 were studied using immunohistochemistry on tissue sections from 42 transitional cell carcinomas ..
  30. Kim S, Stice J, Chen L, Jung J, Gupta S, Wang Y, et al. Extracellular heat shock protein 60, cardiac myocytes, and apoptosis. Circ Res. 2009;105:1186-95 pubmed publisher
    ..b>HSP60 has been reported to be a ligand of toll-like receptor (TLR)-4...
  31. Yuan J, Dunn P, Martinus R. Detection of Hsp60 in saliva and serum from type 2 diabetic and non-diabetic control subjects. Cell Stress Chaperones. 2011;16:689-93 pubmed publisher
    ..Heat shock protein (Hsp60) is a mitochondrial stress protein known to be induced under conditions of mitochondrial impairment...
  32. Pockley A, Bulmer J, Hanks B, Wright B. Identification of human heat shock protein 60 (Hsp60) and anti-Hsp60 antibodies in the peripheral circulation of normal individuals. Cell Stress Chaperones. 1999;4:29-35 pubmed
    ..Although primarily regarded as being intracellular, this study has identified the presence of heat shock protein 60 (Hsp60) in the peripheral circulation of normal individuals. The median Hsp60 concentration was approximately 3...
  33. Johnson B, Le T, Dobbin C, Banovic T, Howard C, Flores F, et al. Heat shock protein 10 inhibits lipopolysaccharide-induced inflammatory mediator production. J Biol Chem. 2005;280:4037-47 pubmed
    Heat shock protein 10 (Hsp10) and heat shock protein 60 (Hsp60) were originally described as essential mitochondrial proteins involved in protein folding...
  34. Campanella C, Bucchieri F, Ardizzone N, Marino Gammazza A, Montalbano A, Ribbene A, et al. Upon oxidative stress, the antiapoptotic Hsp60/procaspase-3 complex persists in mucoepidermoid carcinoma cells. Eur J Histochem. 2008;52:221-8 pubmed
    b>Hsp60, a mitochondrial chaperonin highly conserved during evolution, has been found elevated in the cytosol of cancer cells, both in vivo and in vitro, but its role in determining apoptosis during oxidative stress (OS) has not yet been ..
  35. Abu Hadid M, Wilkes J, Elakawi Z, Pendyala L, Perez R. Relationship between heat shock protein 60 (HSP60) mRNA expression and resistance to platinum analogues in human ovarian and bladder carcinoma cell lines. Cancer Lett. 1997;119:63-70 pubmed
    Heat shock protein 60 (HSP60) participates in protein assembly, folding and transport...
  36. Shamaei Tousi A, Steptoe A, O Donnell K, Palmen J, Stephens J, Hurel S, et al. Plasma heat shock protein 60 and cardiovascular disease risk: the role of psychosocial, genetic, and biological factors. Cell Stress Chaperones. 2007;12:384-92 pubmed
    ..The levels of circulating Hsp60 in 860 participants from the Whitehall cohort and 761 individuals diagnosed with diabetes have been measured and ..
  37. Flohé S, Brüggemann J, Lendemans S, Nikulina M, Meierhoff G, Flohe S, et al. Human heat shock protein 60 induces maturation of dendritic cells versus a Th1-promoting phenotype. J Immunol. 2003;170:2340-8 pubmed
    ..In the present study, we characterized the effects of human HSP60 maturation, cytokine release, and T cell-activating capacity of bone marrow-derived dendritic cells (DC)...
  38. Pfister G, Stroh C, Perschinka H, Kind M, Knoflach M, Hinterdorfer P, et al. Detection of HSP60 on the membrane surface of stressed human endothelial cells by atomic force and confocal microscopy. J Cell Sci. 2005;118:1587-94 pubmed
    ..In the present study, the surface localization of HSP60 on stressed and unstressed human umbilical venous endothelial cells (HUVECs) was investigated using sensitive high ..
  39. Chiu C, Lin C, Lee L, Chen Y, Lu Y, Wang H, et al. Molecular chaperones as a common set of proteins that regulate the invasion phenotype of head and neck cancer. Clin Cancer Res. 2011;17:4629-41 pubmed publisher
    ..expressed in five sublines, Hsp90?, Hsp90?, Hsp90-B1/Gp96, Hsp70-A5/Grp78, and HYOU1, that upregulate, whereas Hsp60 and glucosidase-? neutral AB (GANAB) downregulate. Four molecules were further investigated...
  40. Dunachie S, Jenjaroen K, Reynolds C, Quigley K, Sergeant R, Sumonwiriya M, et al. Infection with Burkholderia pseudomallei - immune correlates of survival in acute melioidosis. Sci Rep. 2017;7:12143 pubmed publisher
    ..T cell immunity to GroEL (BPSL2697) was specifically impaired in diabetic individuals...
  41. Buján N, Mohammed H, Balboa S, Romalde J, Toranzo A, Arias C, et al. Genetic studies to re-affiliate Edwardsiella tarda fish isolates to Edwardsiella piscicida and Edwardsiella anguillarum species. Syst Appl Microbiol. 2018;41:30-37 pubmed publisher
    ..The study of the taxonomic resolution of the genes 16S rRNA, adk, atpD, dnaJ, glnA, hsp60, tuf as well as the possible combinations among housekeeping genes, showed that the gene dnaJ was the more ..
  42. Qiu J, Gao H, Liang Y, Yu H, Zhou R. Comparative proteomics analysis reveals role of heat shock protein 60 in digoxin-induced toxicity in human endothelial cells. Biochim Biophys Acta. 2008;1784:1857-64 pubmed publisher
    ..H3, lamin A, profilin-1, proteasome subunit 5, succinyl-CoA ligase beta chain and heat shock protein 60 (HSP60)...
  43. Lorenzo N, Altruda F, Silengo L, Del Carmen Domínguez M. APL-1, an altered peptide ligand derived from heat-shock protein, alone or combined with methotrexate attenuates murine collagen-induced arthritis. Clin Exp Med. 2017;17:209-216 pubmed publisher
    ..is an altered peptide ligand derived from a novel CD4 + T cell epitope of human heat-shock protein of 60 kDa (HSP60), an autoantigen involved in the pathogenesis of rheumatoid arthritis (RA)...
  44. Lee S, VanBik D, Kim N, Park S, Kwon O, Kim T, et al. First molecular detection and genetic analysis of Anaplasma phagocytophilum in shelter cats in Seoul, Korea. Infect Genet Evol. 2016;46:71-73 pubmed publisher
    ..9%) out of 222 shelter cats from Seoul, Korea, yielded positive results for the A. phagocytophilum 16S rRNA, groEL, and msp2 genes...
  45. Guisasola M, Dulín E, Almendral J, García Barreno P. Reduction of heat shock protein antibody levels by statin therapy. Lipids. 2009;44:317-24 pubmed publisher
    ..effects, paying special attention to the measurement of circulating concentrations of anti-Hsp70 and anti-Hsp60 antibodies previously related to vascular disease...
  46. Ding J, Li J, Yang D, Yang F, Nie H, Huo Z, et al. Molecular characteristics of a novel HSP60 gene and its differential expression in Manila clams (Ruditapes philippinarum) under thermal and hypotonic stress. Cell Stress Chaperones. 2018;23:179-187 pubmed publisher
    ..Heat shock protein 60 (HSP60) is an evolutionarily conserved, multi-functional protein that plays a significant role in protecting organisms ..
  47. Dapunt U, Gaida M, Meyle E, Prior B, Hänsch G. Activation of phagocytic cells by Staphylococcus epidermidis biofilms: effects of extracellular matrix proteins and the bacterial stress protein GroEL on netosis and MRP-14 release. Pathog Dis. 2016;74: pubmed publisher
    ..entities within the extracellular polymeric substance (EPS) of biofilms (the bacterial heat shock protein GroEL) and that this process does not require opsonization...
  48. Cazzaniga A, Maier J, Castiglioni S. Impact of simulated microgravity on human bone stem cells: New hints for space medicine. Biochem Biophys Res Commun. 2016;473:181-186 pubmed publisher
    ..Positioning Machine and found that mesenchymal stem cells respond to gravitational unloading by upregulating HSP60, HSP70, cyclooxygenase 2 and superoxyde dismutase 2...
  49. Zhang T, Shen S, Qu J, Ghaemmaghami S. Global Analysis of Cellular Protein Flux Quantifies the Selectivity of Basal Autophagy. Cell Rep. 2016;14:2426-39 pubmed publisher
    ..This selectivity may establish a proteostatic feedback mechanism that stabilizes the proteasome and CCT/TRiC when autophagy is inhibited. ..
  50. Pons M, Silva Caso W, Del Valle Mendoza J, Ruiz J. Multi-Locus Sequence Typing of Bartonella bacilliformis DNA Performed Directly from Blood of Patients with Oroya's Fever During a Peruvian Outbreak. PLoS Negl Trop Dis. 2016;10:e0004391 pubmed publisher
    ..fever were analyzed with MLST, with the amplification of 7 genetic loci (ftsZ, flaA, ribC, rnpB, rpoB, bvrR and groEL) and a phylogenetic analysis of the different Sequence Types (ST) was performed...
  51. Tong Y, Feng S, Xin Y, Yang H, Zhang L, Wang W, et al. Enhancement of soluble expression of codon-optimized Thermomicrobium roseum sarcosine oxidase in Escherichia coli via chaperone co-expression. J Biotechnol. 2016;218:75-84 pubmed publisher
    ..that the soluble expression of TrSOX was greatly improved by the co-expression of molecular chaperones GroES-GroEL and DnaK-DnaJ-GrpE-GroES-GroEL...
  52. Lin L, Pan S, Zhao J, Liu C, Wang P, Fu L, et al. HSPD1 interacts with IRF3 to facilitate interferon-beta induction. PLoS ONE. 2014;9:e114874 pubmed publisher
    ..In the present study, heat shock protein 60 (HSP60, HSPD1) was identified as a novel IRF3-interacting protein...
  53. Lehnardt S, Schott E, Trimbuch T, Laubisch D, Krueger C, Wulczyn G, et al. A vicious cycle involving release of heat shock protein 60 from injured cells and activation of toll-like receptor 4 mediates neurodegeneration in the CNS. J Neurosci. 2008;28:2320-31 pubmed publisher
    ..We show here that the intracellular chaperone heat shock protein 60 (HSP60) serves as a signal of CNS injury by activating microglia through a toll-like receptor 4 (TLR4)-dependent and ..
  54. Kreutmayer S, Csordas A, Kern J, Maass V, Almanzar G, Offterdinger M, et al. Chlamydia pneumoniae infection acts as an endothelial stressor with the potential to initiate the earliest heat shock protein 60-dependent inflammatory stage of atherosclerosis. Cell Stress Chaperones. 2013;18:259-68 pubmed publisher
    ..pneumoniae as a potent primary endothelial stressor for arterial endothelial cells leading to enrichment of hHSP60 on the cellular membrane and, as such, a potential initiator of atherosclerosis...
  55. Counts J, Hester T, Rouhana L. Genetic expansion of chaperonin-containing TCP-1 (CCT/TRiC) complex subunits yields testis-specific isoforms required for spermatogenesis in planarian flatworms. Mol Reprod Dev. 2017;: pubmed publisher
  56. Hittelman A, Burakov D, Iñiguez Lluhí J, Freedman L, Garabedian M. Differential regulation of glucocorticoid receptor transcriptional activation via AF-1-associated proteins. EMBO J. 1999;18:5380-8 pubmed
    ..These results suggest that DRIP150 and DRIP205 functionally link GR AF-1 and AF-2, and represent important mediators of GR transcriptional enhancement. ..
  57. Cappello F, Conway de Macario E, Rappa F, Zummo G, Macario A. Immunohistochemistry of Human Hsp60 in Health and Disease: From Autoimmunity to Cancer. Methods Mol Biol. 2018;1709:293-305 pubmed publisher
    b>Hsp60 (also called Cpn60) is a chaperonin with essential functions for cell physiology and survival. Additionally, its involvement in the pathogenesis of a variety of diseases (e.g...
  58. Cohen Sfady M, Nussbaum G, Pevsner Fischer M, Mor F, Carmi P, Zanin Zhorov A, et al. Heat shock protein 60 activates B cells via the TLR4-MyD88 pathway. J Immunol. 2005;175:3594-602 pubmed
    ..We found that human HSP60 (but not the Escherichia coli GroEL or the Mycobacterial HSP65 molecules) induced naive mouse B cells to proliferate and to secrete IL-10 and IL-6...
  59. Kang S, Shin M, Kim J, Oh J. Proteomic profiling of cellular proteins interacting with the hepatitis C virus core protein. Proteomics. 2005;5:2227-37 pubmed
    ..We discuss the functional implications of the interactions of the core protein with newly identified cellular proteins in HCV infection and pathogenesis...
  60. Illingworth M, Hooppaw A, Ruan L, Fisher D, Chen L. Biochemical and Genetic Analysis of the Chlamydia GroEL Chaperonins. J Bacteriol. 2017;199: pubmed publisher
    ..In addition to the presence of groEL and groES homologs, groEL paralogs are found in many bacteria, including pathogens, and have ..
  61. Panneerselvam L, Raghunath A, Perumal E. Differential expression of myocardial heat shock proteins in rats acutely exposed to fluoride. Cell Stress Chaperones. 2017;22:743-750 pubmed publisher
    ..The present study was aimed to decipher the status of myocardial heat shock proteins (Hsps-Hsp27, Hsp32, Hsp40, Hsp60, Hsp70, Hsp90) and heat shock transcription factor 1 (Hsf1) in acute F--intoxicated rats...
  62. Bing X, Attardo G, Vigneron A, Aksoy E, Scolari F, Malacrida A, et al. Unravelling the relationship between the tsetse fly and its obligate symbiont Wigglesworthia: transcriptomic and metabolomic landscapes reveal highly integrated physiological networks. Proc Biol Sci. 2017;284: pubmed publisher
    ..i>Wigglesworthia overexpress a molecular chaperone (GroEL) to augment their translational/transport machinery and biosynthesize an abundance of B vitamins (specifically B<..
  63. Wälti M, Schmidt T, Murray D, Wang H, Hinshaw J, Clore G. Chaperonin GroEL accelerates protofibril formation and decorates fibrils of the Het-s prion protein. Proc Natl Acad Sci U S A. 2017;114:9104-9109 pubmed publisher
    We have studied the interaction of the prototypical chaperonin GroEL with the prion domain of the Het-s protein using solution and solid-state NMR, electron and atomic force microscopies, and EPR...
  64. Illingworth M, Ellis H, Chen L. Creating the Functional Single-Ring GroEL-GroES Chaperonin Systems via Modulating GroEL-GroES Interaction. Sci Rep. 2017;7:9710 pubmed publisher
    Chaperonin and cochaperonin, represented by E. coli GroEL and GroES, are essential molecular chaperones for protein folding...
  65. Schafer C, Williams J. Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease. J Gastroenterol. 2000;35:1-9 pubmed
    ..Similarly, a number of Hsps have been identified in pancreas, including Hsp27, Hsp60, and Hsp70...
  66. Tsai Y, Yang M, Huang C, Chang S, Chen P, Liu C, et al. Interaction between HSP60 and beta-catenin promotes metastasis. Carcinogenesis. 2009;30:1049-57 pubmed publisher
    Heat shock protein 60 (HSP60) plays an essential role in assisting many newly synthesized proteins to reach their native forms. Increased HSP60 expression is observed in different types of human cancers with metastasis (e.g...