HSP27

Summary

Gene Symbol: HSP27
Description: heat shock protein family B (small) member 1
Alias: CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27, heat shock protein beta-1, 28 kDa heat shock protein, epididymis secretory protein Li 102, estrogen-regulated 24 kDa protein, heat shock 27 kDa protein, heat shock 27kD protein 1, heat shock 27kDa protein 1, stress-responsive protein 27
Species: human
Products:     HSP27

Top Publications

  1. Lavoie J, Lambert H, Hickey E, Weber L, Landry J. Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol Cell Biol. 1995;15:505-16 pubmed
    Phosphorylation of heat shock protein 27 (HSP27) can modulate actin filament dynamics in response to growth factors...
  2. Rane M, Pan Y, Singh S, Powell D, Wu R, Cummins T, et al. Heat shock protein 27 controls apoptosis by regulating Akt activation. J Biol Chem. 2003;278:27828-35 pubmed
    ..in a signaling complex with p38 MAPK, MAPK-activated protein kinase-2 (MAPKAPK-2), and heat shock protein-27 (Hsp27); and Hsp27 dissociates from the complex upon neutrophil activation...
  3. Kammanadiminti S, Chadee K. Suppression of NF-kappaB activation by Entamoeba histolytica in intestinal epithelial cells is mediated by heat shock protein 27. J Biol Chem. 2006;281:26112-20 pubmed
    ..However in THP-1 conditioned intestinal epithelial cells SAP enhanced Hsp27 and Hsp72, which was dependent on the activation of ERK MAP kinase...
  4. Almeida Souza L, Goethals S, de Winter V, Dierick I, Gallardo R, Van Durme J, et al. Increased monomerization of mutant HSPB1 leads to protein hyperactivity in Charcot-Marie-Tooth neuropathy. J Biol Chem. 2010;285:12778-86 pubmed publisher
    ..We have previously shown that missense mutations in the small heat shock protein HSPB1 (HSP27) cause distal hereditary motor neuropathy and axonal Charcot-Marie-Tooth disease...
  5. Merendino A, Paul C, Vignola A, Costa M, Melis M, Chiappara G, et al. Heat shock protein-27 protects human bronchial epithelial cells against oxidative stress-mediated apoptosis: possible implication in asthma. Cell Stress Chaperones. 2002;7:269-80 pubmed
    ..Here, we have evaluated the extent of apoptosis as well as the Hsp27 level of expression in epithelial cells from bronchial biopsy samples taken from normal and asthmatic subjects...
  6. Zimmermann M, Nickl S, Lambers C, Hacker S, Mitterbauer A, Hoetzenecker K, et al. Discrimination of clinical stages in non-small cell lung cancer patients by serum HSP27 and HSP70: a multi-institutional case-control study. Clin Chim Acta. 2012;413:1115-20 pubmed publisher
    ..Serum levels of HSP27, phospho-HSP27 (pHSP27) and HSP70 in patients with non-small cell lung cancer (NSCLC) diagnosed at an early (..
  7. Sun P, Yoshizuka N, New L, Moser B, Li Y, Liao R, et al. PRAK is essential for ras-induced senescence and tumor suppression. Cell. 2007;128:295-308 pubmed
    ..Furthermore, we show that PRAK activates p53 by direct phosphorylation. We propose that phosphorylation of p53 by PRAK following activation of p38 MAPK by ras plays an important role in ras-induced senescence and tumor suppression. ..
  8. Shashidharamurthy R, Koteiche H, Dong J, McHaourab H. Mechanism of chaperone function in small heat shock proteins: dissociation of the HSP27 oligomer is required for recognition and binding of destabilized T4 lysozyme. J Biol Chem. 2005;280:5281-9 pubmed
    ..To test this hypothesis and define the binding-competent oligomeric state of human Hsp27, we have perturbed the two former equilibria and quantitatively determined the consequences on binding...
  9. Bruey J, Ducasse C, Bonniaud P, Ravagnan L, Susin S, Diaz Latoud C, et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat Cell Biol. 2000;2:645-52 pubmed
    ..Several of these proteins interfere negatively with apoptosis. We show that the small HSP known as Hsp27 inhibits cytochrome-c-mediated activation of caspases in the cytosol...

More Information

Publications72

  1. Wu R, Kausar H, Johnson P, Montoya Durango D, Merchant M, Rane M. Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. J Biol Chem. 2007;282:21598-608 pubmed
    ..Akt exists in a signal complex with p38 MAPK, MAPK-activated protein kinase-2 (MK2), and heat shock protein 27 (Hsp27) and MK2 phosphorylates Akt on Ser-473...
  2. O Callaghan Sunol C, Gabai V, Sherman M. Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res. 2007;67:11779-88 pubmed
    The small heat shock protein Hsp27 is expressed at high levels in many tumors and provides protection against anticancer drugs...
  3. Arrigo A, Firdaus W, Mellier G, Moulin M, Paul C, Diaz Latoud C, et al. Cytotoxic effects induced by oxidative stress in cultured mammalian cells and protection provided by Hsp27 expression. Methods. 2005;35:126-38 pubmed
    ..Finally, techniques to study modalities of constitutive expression of Hsp27 in mammalian cells are considered as well as methods used to determine the protective activity of this small heat ..
  4. Landry J, Lambert H, Zhou M, Lavoie J, Hickey E, Weber L, et al. Human HSP27 is phosphorylated at serines 78 and 82 by heat shock and mitogen-activated kinases that recognize the same amino acid motif as S6 kinase II. J Biol Chem. 1992;267:794-803 pubmed
    The intracellular concentration of the 27-kDa mammalian heat shock protein, HSP27, increases several-fold after heat and other metabolic stresses and is closely associated with the acquisition of thermotolerance...
  5. Langer R, Ott K, Specht K, Becker K, Lordick F, Burian M, et al. Protein expression profiling in esophageal adenocarcinoma patients indicates association of heat-shock protein 27 expression and chemotherapy response. Clin Cancer Res. 2008;14:8279-87 pubmed publisher
    ..and gene expression analysis confirmed these data, showing a significant association between low HSP27 expression and nonresponse to neoadjuvant chemotherapy (P = 0.049 and P = 0.032, respectively)...
  6. Friedman M, Li S, Li X. Activation of gene transcription by heat shock protein 27 may contribute to its neuronal protection. J Biol Chem. 2009;284:27944-51 pubmed publisher
    ..The small heat shock protein HSP27 (or HSPB1) has multiple cytoplasmic roles...
  7. Foster C, Dodson A, Ambroisine L, Fisher G, Møller H, Clark J, et al. Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement. Br J Cancer. 2009;101:1137-44 pubmed publisher
  8. Hayashi N, Peacock J, Beraldi E, Zoubeidi A, Gleave M, Ong C. Hsp27 silencing coordinately inhibits proliferation and promotes Fas-induced apoptosis by regulating the PEA-15 molecular switch. Cell Death Differ. 2012;19:990-1002 pubmed publisher
    Heat shock protein 27 (Hsp27) is emerging as a promising therapeutic target for treatment of various cancers...
  9. Korngut L, Ma C, Martinez J, Toth C, Guo G, Singh V, et al. Overexpression of human HSP27 protects sensory neurons from diabetes. Neurobiol Dis. 2012;47:436-43 pubmed publisher
    ..We explored the intrinsic protective properties of overexpressed human HSP27 on experimental DPN. HSP27 is a small pro-survival heat shock protein that also increases axonal regeneration...
  10. Cuesta R, Laroia G, Schneider R. Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. Genes Dev. 2000;14:1460-70 pubmed
    ..We demonstrate that chaperone Hsp27 is a heat shock-induced inhibitor of cellular protein synthesis...
  11. Sun X, Fontaine J, Rest J, Shelden E, Welsh M, Benndorf R. Interaction of human HSP22 (HSPB8) with other small heat shock proteins. J Biol Chem. 2004;279:2394-402 pubmed
    ..Recently a new sHSP, HSP22 (HSPB8, H11), was identified in the human heart by its interaction with HSP27 (HSPB1). Using phylogenetic analysis we show that HSP22 is a true member of the sHSP superfamily...
  12. Parcellier A, Schmitt E, Gurbuxani S, Seigneurin Berny D, Pance A, Chantome A, et al. HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Mol Cell Biol. 2003;23:5790-802 pubmed
    b>HSP27 is an ATP-independent chaperone that confers protection against apoptosis through various mechanisms, including a direct interaction with cytochrome c...
  13. Charette S, Landry J. The interaction of HSP27 with Daxx identifies a potential regulatory role of HSP27 in Fas-induced apoptosis. Ann N Y Acad Sci. 2000;926:126-31 pubmed
    The heat shock protein HSP27 protects cells against a wide variety of toxic treatments and blocks apoptosis induced by exposures to anticancer drugs and activation of the death receptor Fas...
  14. Xu L, Chen S, Bergan R. MAPKAPK2 and HSP27 are downstream effectors of p38 MAP kinase-mediated matrix metalloproteinase type 2 activation and cell invasion in human prostate cancer. Oncogene. 2006;25:2987-98 pubmed
    ..protein kinase 2 (MAPKAPK2), a known substrate of p38 MAP kinase, as well as heat-shock protein 27 (HSP27), a known substrate of MAPKAPK2, in both PC3 and PC3-M human prostate cells...
  15. Kim E, Lee H, Lee D, Bae S, Soh J, Jeoung D, et al. Inhibition of heat shock protein 27-mediated resistance to DNA damaging agents by a novel PKC delta-V5 heptapeptide. Cancer Res. 2007;67:6333-41 pubmed
    Heat shock protein 27 (HSP27), which is highly expressed in human lung and breast cancer tissues, induced resistance to cell death against various stimuli...
  16. Voss O, Batra S, Kolattukudy S, Gonzalez Mejia M, Smith J, Doseff A. Binding of caspase-3 prodomain to heat shock protein 27 regulates monocyte apoptosis by inhibiting caspase-3 proteolytic activation. J Biol Chem. 2007;282:25088-99 pubmed
    ..Here we show that the small heat shock protein 27 (Hsp27) associates with caspase-3 and protein-protein interaction experiments in vivo and with purified proteins ..
  17. Tsuruta M, Nishibori H, Hasegawa H, Ishii Y, Endo T, Kubota T, et al. Heat shock protein 27, a novel regulator of 5-fluorouracil resistance in colon cancer. Oncol Rep. 2008;20:1165-72 pubmed
    ..Heat shock protein 27 (HSP27) mRNA expression has recently been shown to be correlated with 5-FU resistance in 5-FU-resistant cell lines...
  18. Wu Y, Liu J, Zhang Z, Huang H, Shen J, Zhang S, et al. HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination. Cell Signal. 2009;21:143-50 pubmed publisher
    Heat shock protein 27 (HSP27) is an ubiquitiously expressed protein, which has been mediated in various biological functions...
  19. Charette S, Lavoie J, Lambert H, Landry J. Inhibition of Daxx-mediated apoptosis by heat shock protein 27. Mol Cell Biol. 2000;20:7602-12 pubmed
    Heat shock protein 27 (HSP27) confers cellular protection against a variety of cytotoxic stresses and also against physiological stresses associated with growth arrest or receptor-mediated apoptosis...
  20. Guo H, Bai Y, Xu P, Hu Z, Liu L, Wang F, et al. Functional promoter -1271G>C variant of HSPB1 predicts lung cancer risk and survival. J Clin Oncol. 2010;28:1928-35 pubmed publisher
    PURPOSE Heat-shock protein 27 (Hsp27), encoded by HSPB1, plays crucial roles in tumorigenesis and cell survival and is reported to be an independent prognosis marker for cancer...
  21. Gibert B, Hadchity E, Czekalla A, Aloy M, Colas P, Rodriguez Lafrasse C, et al. Inhibition of heat shock protein 27 (HspB1) tumorigenic functions by peptide aptamers. Oncogene. 2011;30:3672-81 pubmed publisher
    Human heat shock protein 27 (Hsp27, HspB1) is an anti-apoptotic protein characterized for its tumorigenic and metastatic properties, and now referenced as a major therapeutic target in many types of cancer...
  22. Almeida Souza L, Asselbergh B, d Ydewalle C, Moonens K, Goethals S, de Winter V, et al. Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy. J Neurosci. 2011;31:15320-8 pubmed publisher
    Mutations in the small heat shock protein HSPB1 (HSP27) are causative for Charcot-Marie-Tooth (CMT) neuropathy...
  23. Miller H, Poon S, Hibbert B, Rayner K, Chen Y, O Brien E. Modulation of estrogen signaling by the novel interaction of heat shock protein 27, a biomarker for atherosclerosis, and estrogen receptor beta: mechanistic insight into the vascular effects of estrogens. Arterioscler Thromb Vasc Biol. 2005;25:e10-4 pubmed
    ..Using a yeast 2-hybrid screen, we identified heat shock protein 27 (HSP27) as an ERbeta-associated protein...
  24. Song H, Ethier S, Dziubinski M, Lin J. Stat3 modulates heat shock 27kDa protein expression in breast epithelial cells. Biochem Biophys Res Commun. 2004;314:143-50 pubmed
    ..Our results showed that heat shock 27kDa protein (HSP27) was markedly induced by Stat3-C expression...
  25. New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood L, et al. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J. 1998;17:3372-84 pubmed
    ..Activated PRAK in turn phosphorylated small heat shock protein 27 (HSP27) at the physiologically relevant sites...
  26. Zhao M, Ding J, Zeng K, Zhao J, Shen F, Yin Y, et al. Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?. Tumour Biol. 2014;35:1051-6 pubmed publisher
    ..The early detection of peritoneal metastases in epithelial ovarian cancer may be more important in clinical care. HSP27, a small heat shock protein, is correlated with peritoneal metastases in epithelial ovarian cancer tissues...
  27. Kostenko S, Johannessen M, Moens U. PKA-induced F-actin rearrangement requires phosphorylation of Hsp27 by the MAPKAP kinase MK5. Cell Signal. 2009;21:712-8 pubmed publisher
    ..In particular, the p38 MAPK/MAPK-activated protein kinase 2 (MK2)/heat shock protein 27 (Hsp27) pathway is involved in F-actin alternations...
  28. Hino M, Kurogi K, Okubo M, Murata Hori M, Hosoya H. Small heat shock protein 27 (HSP27) associates with tubulin/microtubules in HeLa cells. Biochem Biophys Res Commun. 2000;271:164-9 pubmed
    ..Immunoscreening of a HeLa cDNA library revealed that mH3 antigen is a small heat shock protein, HSP27. Immunoprecipitation analysis using mH3 suggested that both alpha- and beta-tubulin are associated with HSP27...
  29. Chen S, Kim M, Kim M, Song J, Park S, Wells D, et al. Mice that overexpress human heat shock protein 27 have increased renal injury following ischemia reperfusion. Kidney Int. 2009;75:499-510 pubmed publisher
    ..the kidney against ischemia-reperfusion injury by induction and phosphorylation of heat shock protein 27 (HSP27)...
  30. Hickey E, Brandon S, Potter R, Stein G, Stein J, Weber L. Sequence and organization of genes encoding the human 27 kDa heat shock protein. Nucleic Acids Res. 1986;14:4127-45 pubmed
    The 27 kDa human heat shock protein (hsp27) is encoded by a gene family of 4 members. Two genomic fragments hybridizing to cDNA encoding hsp27 have been isolated, characterized, and sequenced...
  31. Vasiljevic N, Ahmad A, Beesley C, Thorat M, Fisher G, Berney D, et al. Association between DNA methylation of HSPB1 and death in low Gleason score prostate cancer. Prostate Cancer Prostatic Dis. 2013;16:35-40 pubmed publisher
  32. Evgrafov O, Mersiyanova I, Irobi J, Van Den Bosch L, Dierick I, Leung C, et al. Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. Nat Genet. 2004;36:602-6 pubmed
    ..reported a Russian family with autosomal dominant axonal CMT and assigned the locus underlying the disease (CMT2F; OMIM 606595) to chromosome 7q11-q21 (ref. 2)...
  33. Jakob U, Gaestel M, Engel K, Buchner J. Small heat shock proteins are molecular chaperones. J Biol Chem. 1993;268:1517-20 pubmed
    ..To test this hypothesis we studied the influence of murine Hsp25, human Hsp27, and bovine alpha-B-crystallin (an eye lens protein homologous to sHsps) on the unfolding and refolding of citrate ..
  34. Thuringer D, Jego G, Wettstein G, Terrier O, Cronier L, Yousfi N, et al. Extracellular HSP27 mediates angiogenesis through Toll-like receptor 3. FASEB J. 2013;27:4169-83 pubmed publisher
    The heat-shock protein 27 (HSP27) is up-regulated in tumor cells and released in their microenvironment. Here, we show that extracellular HSP27 has a proangiogenic effect evidenced on chick chorioallantoic membrane...
  35. Delbecq S, Jehle S, Klevit R. Binding determinants of the small heat shock protein, ?B-crystallin: recognition of the 'IxI' motif. EMBO J. 2012;31:4587-94 pubmed publisher
    ..IxI-mimicking peptides bind the isolated ACD at 22°C in a manner similar to interactions observed in the oligomer at low temperature, confirming these interactions are likely to exist in functional ?B oligomers. ..
  36. Liao W, Wu M, Wang H, Tien Y, Lin J. Serum heat shock protein 27 is increased in chronic pancreatitis and pancreatic carcinoma. Pancreas. 2009;38:422-6 pubmed publisher
    A prior study suggested serum heat shock protein 27 (HSP27) as a potential marker for pancreatic carcinoma, but its accuracy in differentiating cancer from chronic pancreatitis was not evaluated...
  37. Brunet Simioni M, de Thonel A, Hammann A, Joly A, Bossis G, Fourmaux E, et al. Heat shock protein 27 is involved in SUMO-2/3 modification of heat shock factor 1 and thereby modulates the transcription factor activity. Oncogene. 2009;28:3332-44 pubmed publisher
    Heat shock protein 27 (HSP27) accumulates in stressed cells and helps them to survive adverse conditions...
  38. Paul C, Manero F, Gonin S, Kretz Remy C, Virot S, Arrigo A. Hsp27 as a negative regulator of cytochrome C release. Mol Cell Biol. 2002;22:816-34 pubmed
    We previously showed that Hsp27 protects against apoptosis through its interaction with cytosolic cytochrome c. We have revisited this protective activity in murine cell lines expressing different levels of Hsp27...
  39. Ghosh A, Lai C, McDonald S, Suraweera N, Sengupta N, Propper D, et al. HSP27 expression in primary colorectal cancers is dependent on mutation of KRAS and PI3K/AKT activation status and is independent of TP53. Exp Mol Pathol. 2013;94:103-8 pubmed publisher
    ..Here, we characterised the expression of two major HSP proteins (HSP27 and 72) by immunohistochemistry (IHC), the mutation status of TP53, KRAS and PIK3CA genes by direct sequencing and ..
  40. Stokoe D, Engel K, Campbell D, Cohen P, Gaestel M. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett. 1992;313:307-13 pubmed
    ..protein kinase-2 (MAPKAP kinase-2) phosphorylates the serine residues in murine heat shock protein 25 (hsp25) and human heat shock protein 27 (hsp27) which are phosphorylated in vivo in response to growth factors and heat ..
  41. Joanisse D, Inaguma Y, Tanguay R. Cloning and developmental expression of a nuclear ubiquitin-conjugating enzyme (DmUbc9) that interacts with small heat shock proteins in Drosophila melanogaster. Biochem Biophys Res Commun. 1998;244:102-9 pubmed
    ..Further, two-hybrid system analysis reveals DmUbc9 interaction with Drosophila and mammalian Hsp27. In situ hybridization localizes Dmubc9 as a doublet at locus 21D on chromosome 2L, and genomic cloning of the ..
  42. Gibert B, Eckel B, Fasquelle L, Moulin M, Bouhallier F, Gonin V, et al. Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. PLoS ONE. 2012;7:e29719 pubmed publisher
    b>Hsp27 belongs to the heat shock protein family and displays chaperone properties in stress conditions by holding unfolded polypeptides, hence avoiding their inclination to aggregate...
  43. Tang B, Liu X, Zhao G, Luo W, Xia K, Pan Q, et al. Mutation analysis of the small heat shock protein 27 gene in chinese patients with Charcot-Marie-Tooth disease. Arch Neurol. 2005;62:1201-7 pubmed
    ..Recently, mutations in small heat shock protein 27 (Hsp27) were reported to cause CMT disease type 2F and distal hereditary motor neuropathy...
  44. López Guerra J, Wei Q, Yuan X, Gomez D, Liu Z, Zhuang Y, et al. Functional promoter rs2868371 variant of HSPB1 associates with radiation-induced esophageal toxicity in patients with non-small-cell lung cancer treated with radio(chemo)therapy. Radiother Oncol. 2011;101:271-7 pubmed publisher
    ..This finding should be validated in large multi-institutional prospective trials. ..
  45. de Souza A, Wait R, Mitchell A, Banner N, Dunn M, Rose M. Heat shock protein 27 is associated with freedom from graft vasculopathy after human cardiac transplantation. Circ Res. 2005;97:192-8 pubmed
    ..04). This spot was identified by mass spectrometry and a combination of techniques as a diphosphorylated form of HSP27. Immunohistochemistry of further biopsies not only validated that HSP27 was more abundantly expressed on biopsies ..
  46. Marin Vinader L, Shin C, Onnekink C, Manley J, Lubsen N. Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock. Mol Biol Cell. 2006;17:886-94 pubmed
    A heat stress causes a rapid inhibition of splicing. Exogenous expression of Hsp27 did not prevent that inhibition but enhanced the recovery of splicing afterward. Another small heat shock protein, alphaB-crystallin, had no effect...
  47. Knapinska A, Gratacós F, Krause C, Hernandez K, Jensen A, Bradley J, et al. Chaperone Hsp27 modulates AUF1 proteolysis and AU-rich element-mediated mRNA degradation. Mol Cell Biol. 2011;31:1419-31 pubmed publisher
    ..We recently found chaperone Hsp27 to be an AUF1-associated ARE-binding protein required for tumor necrosis factor alpha (TNF-?) mRNA degradation in ..
  48. Zoubeidi A, Zardan A, Beraldi E, Fazli L, Sowery R, Rennie P, et al. Cooperative interactions between androgen receptor (AR) and heat-shock protein 27 facilitate AR transcriptional activity. Cancer Res. 2007;67:10455-65 pubmed
    ..novel feed-forward loop involving cooperative interactions between ligand-activated AR and heat-shock protein 27 (Hsp27) phospho-activation that enhance AR stability, shuttling, and transcriptional activity, thereby increasing ..
  49. Bausero M, Bharti A, Page D, Perez K, Eng J, Ordonez S, et al. Silencing the hsp25 gene eliminates migration capability of the highly metastatic murine 4T1 breast adenocarcinoma cell. Tumour Biol. 2006;27:17-26 pubmed
    The 25-kDa heat shock protein (Hsp25) is associated with various malignancies and is expressed at high levels in biopsies as well as circulating in the serum of breast cancer patients...
  50. Ackerley S, James P, Kalli A, French S, Davies K, Talbot K. A mutation in the small heat-shock protein HSPB1 leading to distal hereditary motor neuronopathy disrupts neurofilament assembly and the axonal transport of specific cellular cargoes. Hum Mol Genet. 2006;15:347-54 pubmed
    ..Mutations in the small heat-shock protein HSPB1 (HSP27) are responsible for one form of dHMN...
  51. Hacker S, Lambers C, Hoetzenecker K, Pollreisz A, Aigner C, Lichtenauer M, et al. Elevated HSP27, HSP70 and HSP90 alpha in chronic obstructive pulmonary disease: markers for immune activation and tissue destruction. Clin Lab. 2009;55:31-40 pubmed
    ..b>HSP27, HSP70 and HSP90 alpha were significantly altered in patients suffering from COPD as compared to controls...
  52. Aquilina J, Shrestha S, Morris A, Ecroyd H. Structural and functional aspects of hetero-oligomers formed by the small heat shock proteins ?B-crystallin and HSP27. J Biol Chem. 2013;288:13602-9 pubmed publisher
    B-crystallin and HSP27 are mammalian intracellular small heat shock proteins. These proteins exchange subunits in a rapid and temperature-dependent manner...
  53. Al Madhoun A, Chen Y, Haidari L, Rayner K, Gerthoffer W, McBride H, et al. The interaction and cellular localization of HSP27 and ERbeta are modulated by 17beta-estradiol and HSP27 phosphorylation. Mol Cell Endocrinol. 2007;270:33-42 pubmed
    Recently, we identified heat shock protein 27 (HSP27) as an estrogen receptor-beta (ERbeta) associated protein that acts as a co-repressor of estrogen signaling and serves as a biomarker of atherosclerosis...
  54. Chen G, Hitomi M, Han J, Stacey D. The p38 pathway provides negative feedback for Ras proliferative signaling. J Biol Chem. 2000;275:38973-80 pubmed
    ..These studies thus establish a negative feedback mechanism by which Ras proliferative activity is regulated via signaling integrations of MAPK pathways. ..
  55. Jonak C, Mildner M, Klosner G, Paulitschke V, Kunstfeld R, Pehamberger H, et al. The hsp27kD heat shock protein and p38-MAPK signaling are required for regular epidermal differentiation. J Dermatol Sci. 2011;61:32-7 pubmed publisher
    In human epidermal keratinocytes the expression of hsp27 is closely related to differentiation in vitro and in situ...
  56. Baranova E, Weeks S, Beelen S, Bukach O, Gusev N, Strelkov S. Three-dimensional structure of ?-crystallin domain dimers of human small heat shock proteins HSPB1 and HSPB6. J Mol Biol. 2011;411:110-22 pubmed publisher
    ..and solution small-angle X-ray scattering (SAXS) to study the ACD-containing fragments of human HSPB1 (HSP27) and HSPB6 (HSP20)...
  57. Shin J, Jeong Y, Jo H, Kang M, Chang I, Baek J, et al. Increased interaction between heat shock protein 27 and mitogen-activated protein kinase (p38 and extracellular signal-regulated kinase) in pre-eclamptic placentas. J Obstet Gynaecol Res. 2009;35:888-94 pubmed publisher
    Heat shock protein 27 (Hsp27) is a well-known stress response protein that is characterized by its phosphorylative capacity. Hsp27 becomes phosphorylated in response to various stimuli through interaction with several different kinases...
  58. Rogalla T, Ehrnsperger M, Preville X, Kotlyarov A, Lutsch G, Ducasse C, et al. Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation. J Biol Chem. 1999;274:18947-56 pubmed
    The small heat shock proteins (sHsps) from human (Hsp27) and mouse (Hsp25) form large oligomers which can act as molecular chaperones in vitro and protect cells from heat shock and oxidative stress when overexpressed...
  59. Coupland S, Vorum H, Mandal N, Kalirai H, Honoré B, Urbak S, et al. Proteomics of uveal melanomas suggests HSP-27 as a possible surrogate marker of chromosome 3 loss. Invest Ophthalmol Vis Sci. 2010;51:12-20 pubmed publisher
    ..Further validation is necessary to determine whether immunohistochemical assessment of HSP-27 expression correlates with metastatic mortality. ..
  60. Lelj Garolla B, Mauk A. Self-association and chaperone activity of Hsp27 are thermally activated. J Biol Chem. 2006;281:8169-74 pubmed
    The small heat shock protein 27 (Hsp27) is an oligomeric, molecular chaperone in vitro. This chaperone activity and other physiological roles attributed to Hsp27 have been reported to depend on the state of self-association...
  61. Park H, Park E, Bae S, Park M, Kim S, Yoo H, et al. Expression of heat shock protein 27 in human atherosclerotic plaques and increased plasma level of heat shock protein 27 in patients with acute coronary syndrome. Circulation. 2006;114:886-93 pubmed
    ..analysis on carotid atherosclerotic endarterectomy specimens (n = 10) revealed that heat shock protein 27 (Hsp27) expression was significantly increased in the nearby normal-appearing area compared with the plaque core area ..
  62. During R, Gibson B, Li W, Bishai E, Sidhu G, Landry J, et al. Anthrax lethal toxin paralyzes actin-based motility by blocking Hsp27 phosphorylation. EMBO J. 2007;26:2240-50 pubmed
    ..LT inhibition of actin assembly is mediated by blockade of Hsp27 phosphorylation, and can be reproduced by treating cells with the p38 mitogen-activated protein (MAP) kinase ..
  63. Houlden H, Laura M, Wavrant De Vrieze F, Blake J, Wood N, Reilly M. Mutations in the HSP27 (HSPB1) gene cause dominant, recessive, and sporadic distal HMN/CMT type 2. Neurology. 2008;71:1660-8 pubmed publisher
    ..Recently, mutations in both the small heat shock protein 27 (HSP27 or HSPB1) and 22 (HSP22 or HSPB8) genes have been reported to cause autosomal dominant CMT with minimal sensory ..