Gene Symbol: HSF2
Description: heat shock transcription factor 2
Alias: HSF 2, HSTF 2, heat shock factor protein 2
Species: human
Products:     HSF2

Top Publications

  1. Zhang J, Goodson M, Hong Y, Sarge K. MEL-18 interacts with HSF2 and the SUMO E2 UBC9 to inhibit HSF2 sumoylation. J Biol Chem. 2008;283:7464-9 pubmed publisher
    In a previous study we found that sumoylation of the DNA-binding protein heat shock factor 2 (HSF2) is up-regulated during mitosis, but the mechanism that mediates this regulation was unknown...
  2. Sarge K, Zimarino V, Holm K, Wu C, Morimoto R. Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability. Genes Dev. 1991;5:1902-11 pubmed
    ..Both mHSF1 and mHSF2 are encoded by single-copy genes, and neither is transcriptionally regulated by heat shock. However, there is a striking difference in the levels of mHSF1 mRNA in different tissues of the mouse. ..
  3. Sandqvist A, Björk J, Akerfelt M, Chitikova Z, Grichine A, Vourc h C, et al. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Mol Biol Cell. 2009;20:1340-7 pubmed publisher
    ..Of the four HSFs in vertebrates (HSF1-4), HSF1 is activated by stress, whereas HSF2 lacks intrinsic stress responsiveness...
  4. Ahlskog J, Björk J, Elsing A, Aspelin C, Kallio M, Roos Mattjus P, et al. Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. Mol Cell Biol. 2010;30:5608-20 pubmed publisher
    ..substrate recognition by both Cdc20 and Cdh1, mediates ubiquitination and degradation of heat shock factor 2 (HSF2), a transcription factor that binds to the Hsp70 promoter...
  5. Östling P, Björk J, Roos Mattjus P, Mezger V, Sistonen L. Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. J Biol Chem. 2007;282:7077-86 pubmed
    ..Mammalian HSF1 was originally identified as the transcriptional regulator of the heat shock response, whereas HSF2 has not been implicated a role in the stress response...
  6. Xing H, Wilkerson D, Mayhew C, Lubert E, Skaggs H, Goodson M, et al. Mechanism of hsp70i gene bookmarking. Science. 2005;307:421-3 pubmed
    ..Here we show that hsp70i bookmarking is mediated by a transcription factor called HSF2, which binds this promoter in mitotic cells, recruits protein phosphatase 2A, and interacts with the CAP-G subunit ..
  7. Alastalo T, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L. Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. J Cell Sci. 2003;116:3557-70 pubmed
    ..In this study, we demonstrate that the less-well characterized HSF2 interacts physically with HSF1 and is a novel stress-responsive component of the stress granules...
  8. Vihervaara A, Sergelius C, Vasara J, Blom M, Elsing A, Roos Mattjus P, et al. Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells. Proc Natl Acad Sci U S A. 2013;110:E3388-97 pubmed publisher
    ..We determined the genomewide transcriptional program that is rapidly provoked by HSF1 and HSF2 under acute stress in human cells...
  9. Amaral I, Johnston I. Circadian expression of clock and putative clock-controlled genes in skeletal muscle of the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2012;302:R193-206 pubmed publisher
    ..7-fold for the repressor per1a. Out of 32 candidate clock-controlled genes, only myf6, igfbp3, igfbp5b, and hsf2 showed circadian expression patterns...

More Information


  1. Wu Y, Yang J, Ai Z, Yu M, Li J, Li S. Identification of key genes and transcription factors in aging mesenchymal stem cells by DNA microarray data. Gene. 2019;692:79-87 pubmed publisher
    ..11 TFs (CREB1, CUX1, EGR1, EP300, FOXC1, HSF2, MEF2A, PLAU, SP1, STAT1 and USF1) for DEGs were predicted and 2 highly scored co-expression relationships (EP300-..
  2. Wang C, Si L, Guo S, Zheng J. Negative effects of acute cadmium on stress defense, immunity, and metal homeostasis in liver of zebrafish: The protective role of environmental zinc dpre-exposure. Chemosphere. 2019;222:91-97 pubmed publisher
    ..Thirdly, Zn pre-exposure alone up-regulated transcription factors (hsf1, hsf2, and mtf-1, and nrf2) and their target genes (sod1, cat, hsp70, and mt2) under Cd exposure in a dose-dependent ..
  3. Zhang L, Qin Y, Gong X, Peng R, Cai C, Zheng Y, et al. A promoter variant in ZNF804A decreasing its expression increases the risk of autism spectrum disorder in the Han Chinese population. Transl Psychiatry. 2019;9:31 pubmed publisher
    ..b>HSF2 acted as a suppressor by down-regulating ZNF804A expression and had a stronger binding affinity for the T allele of ..
  4. Mathew A, Mathur S, Morimoto R. Heat shock response and protein degradation: regulation of HSF2 by the ubiquitin-proteasome pathway. Mol Cell Biol. 1998;18:5091-8 pubmed
    ..by heat shock and other stresses that result in the appearance of nonnative proteins, the stress signal for HSF2 has not been identified...
  5. Allais L, Zhao C, Fu M, Hu J, Qin J, Qiu L, et al. Nutrition and water temperature regulate the expression of heat-shock proteins in golden pompano larvae (Trachinotus ovata, Limmaeus 1758). Fish Physiol Biochem. 2018;: pubmed publisher
    ..Nannochloropsis sp.-enriched Artemia nauplii treatment was found to be the most appropriate feed type with moderate relative expressions of HSP60, HSP70, HSF1, HSF2, and GRP94.
  6. Wang H, Li X, Li P, Liu W, Du Z, Li J. Modulation of heat-shock response is associated with Di (2-ethylhexyl) phthalate (DEHP)-induced cardiotoxicity in quail (Coturnix japonica). Chemosphere. 2019;214:812-820 pubmed publisher
    ..In addition, the levels of HSF1, HSF2, and HSF3 were significantly increased...
  7. Fujimoto M, Hayashida N, Katoh T, Oshima K, Shinkawa T, Prakasam R, et al. A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock. Mol Biol Cell. 2010;21:106-16 pubmed publisher
    ..It is believed that HSF1 is required for the heat-inducible expression of these genes although HSF2 and HSF4 modulate some of the gene expression...
  8. Si L, Wang C, Guo S, Zheng J, Xia H. The lagged effects of environmentally relevant zinc on non-specific immunity in zebrafish. Chemosphere. 2019;214:85-93 pubmed publisher
    ..Although transcriptional levels of sod1, hsf1, hsf2, hsp70, il-6 and il-1β and activity levels of iNOS recovered to the control levels at 4 and 8 d post-exposure, ..
  9. Li P, Sheng C, Huang L, Zhang H, Huang L, Cheng Z, et al. MiR-183/-96/-182 cluster is up-regulated in most breast cancers and increases cell proliferation and migration. Breast Cancer Res. 2014;16:473 pubmed publisher
    ..The miR-183/-96/-182 cluster was transcribed in the same pri-miRNA and its transcription was regulated by ZEB1 and HSF2. It increased breast cell growth by promoting more rapid completion of mitosis, promoted cell migration and was ..
  10. Narumi T, Shishido T, Otaki Y, Kadowaki S, Honda Y, Funayama A, et al. High-mobility group box 1-mediated heat shock protein beta 1 expression attenuates mitochondrial dysfunction and apoptosis. J Mol Cell Cardiol. 2015;82:1-12 pubmed publisher
    ..Cardiac HMGB1 increases HSPB1 expression in cardiomyocytes in a heat shock factor 2-dependent manner. ..
  11. Kim S, Chang Z, Park J. Identification, tissue distribution and characterization of two heat shock factors (HSFs) in goldfish (Carassius auratus). Fish Shellfish Immunol. 2015;43:375-86 pubmed publisher
    ..paper reports the cDNA cloning of two goldfish (Carassius auratus) HSF gene families, HSF1 and three isoforms of HSF2. Both HSF1 and HSF2s showed high homology to the known HSFs from other organisms, particularly the zebrafish...
  12. Korfanty J, Stokowy T, Widlak P, Gogler Piglowska A, Handschuh L, Podkowiński J, et al. Crosstalk between HSF1 and HSF2 during the heat shock response in mouse testes. Int J Biochem Cell Biol. 2014;57:76-83 pubmed publisher
    ..Heat Shock Factor 1 (HSF1) is the primary transcription factor responsible for the response to cellular stress, while HSF2 becomes activated during development and differentiation, including spermatogenesis...
  13. Kyung H, Kwong J, Bekerman V, Gu L, Yadegari D, Caprioli J, et al. Celastrol supports survival of retinal ganglion cells injured by optic nerve crush. Brain Res. 2015;1609:21-30 pubmed publisher
    ..The expression levels of Hsp70, Hsf1, Hsf2, HO-1 and TNF-alpha in the retina were analyzed to evaluate the roles of these proteins in the celastrol-mediated ..
  14. Shukla P, Gupta K, Agarwal P, Jha B, Agarwal P. Overexpression of a novel SbMYB15 from Salicornia brachiata confers salinity and dehydration tolerance by reduced oxidative damage and improved photosynthesis in transgenic tobacco. Planta. 2015;242:1291-308 pubmed publisher
    ..In the transgenic plants, the expression of stress-responsive genes such as LEA5, ERD10D, PLC3, LTP1, HSF2, ADC, P5CS, SOD and CAT was enhanced in the presence of salinity, dehydration and heat...
  15. Mahat D, Salamanca H, Duarte F, Danko C, Lis J. Mammalian Heat Shock Response and Mechanisms Underlying Its Genome-wide Transcriptional Regulation. Mol Cell. 2016;62:63-78 pubmed publisher
    ..Notably, HSF2 does not compensate for the lack of HSF1...
  16. Ohno Y, Egawa T, Yokoyama S, Nakai A, Sugiura T, Ohira Y, et al. Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice. Acta Physiol (Oxf). 2015;215:191-203 pubmed publisher
    ..Neither type of mice exhibited much effect of heat stress on HSF mRNA expression (HSF1, HSF2 and HSF4)...
  17. Chen J, Kuo C, Pai P, Ho T, Chen T, Tsai F, et al. Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity. J Cell Physiol. 2018;233:463-475 pubmed publisher
    ..b>HSF2 markedly translocated from the cytoplasm to the nucleus when cardiomyocytes were damaged by DOX...
  18. Jo S, Lee Y, Kim S, Lee H, Chung H. PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Biochim Biophys Acta. 2016;1863:1499-509 pubmed publisher
    ..group protein, has been suggested as an anti-SUMO E3 protein by inhibiting the sumoylation of UBE2I substrates, HSF2 and RANGAP1, via direct interaction...
  19. Cao J, Chen Y, Chen J, Yan H, Li M, Wang J. Fluoride exposure changed the structure and the expressions of Y chromosome related genes in testes of mice. Chemosphere. 2016;161:292-299 pubmed publisher
    ..Sperm malformation ratio was distinctly elevated. The expressions of Sly and HSF2 mRNA were markedly reduced in 100 mg/L NaF group and Ssty2 mRNA expression was dramatically decreased in 50 and ..
  20. Ferreira T, Moreno L, Felizardo M, de Gobbi D, Filsner P, de Moura Gomes V, et al. Pheno- and genotypic characterization of Pasteurella multocida isolated from cats, dogs and rabbits from Brazil. Comp Immunol Microbiol Infect Dis. 2016;45:48-52 pubmed publisher
    ..The hgbA, ptfA, sodC, tadD and hsf2 genes were more frequent among the rabbit strains...
  21. Cai H, Xue Y, Wang P, Wang Z, Li Z, Hu Y, et al. The long noncoding RNA TUG1 regulates blood-tumor barrier permeability by targeting miR-144. Oncotarget. 2015;6:19759-79 pubmed
    ..Furthermore, Knockdown of TUG1 also down-regulated Heat shock transcription factor 2 (HSF2), a transcription factor of the heat shock transcription factor family, which was defined as a direct and ..
  22. Widlak W, Vydra N. The Role of Heat Shock Factors in Mammalian Spermatogenesis. Adv Anat Embryol Cell Biol. 2017;222:45-65 pubmed publisher
    ..Different HSFs could cooperate to maintain proper spermatogenesis. Cooperation of HSF1 and HSF2 is especially well established since their double knockout results in meiosis arrest, spermatocyte apoptosis, and ..
  23. Shen L, Zhao L, Tang J, Wang Z, Bai W, Zhang F, et al. Key Genes in Stomach Adenocarcinoma Identified via Network Analysis of RNA-Seq Data. Pathol Oncol Res. 2017;23:745-752 pubmed publisher
    ..A total of 20 drugs, 9 TFs and 6 miRNAs were acquired that may regulate the DEGs. NFAT-COL1A1/ANXA1, HSF2-FOS, SREBP-IL1RN and miR-26-COL5A2 regulation axes may be important mechanisms for STAD.
  24. Frigault J, Lang Ouellette D, Morin P. Up-regulation of Long Non-coding RNA TUG1 in Hibernating Thirteen-lined Ground Squirrels. Genomics Proteomics Bioinformatics. 2016;14:113-8 pubmed publisher
    ..Furthermore, transcript levels of HSF2 also increased 2.44-fold in the skeletal muscle in hibernating animals...
  25. Liu X, Wang Y, Dan X, Kumar A, Ye T, Yu Y, et al. Anti-inflammatory potential of β-cryptoxanthin against LPS-induced inflammation in mouse Sertoli cells. Reprod Toxicol. 2016;60:148-55 pubmed publisher
    ..In addition, CX significantly limited the LPS-induced down-regulation of AR, HSF2, CREB, FSHR, INHBB and ABP in Sertoli cells...
  26. Kubota H, Matsumoto S, Yokota S, Yanagi H, Yura T. Transcriptional activation of mouse cytosolic chaperonin CCT subunit genes by heat shock factors HSF1 and HSF2. FEBS Lett. 1999;461:125-9 pubmed
    ..These results suggest that HSF1 and/or HSF2 play a role in Cct gene expression.
  27. Schuetz T, Gallo G, Sheldon L, Tempst P, Kingston R. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc Natl Acad Sci U S A. 1991;88:6911-5 pubmed
    ..amp; Wu, C. (1991) Proc. Natl. Acad. Sci. USA 88, 6906-6910.] It therefore appears that there is a human heat shock factor gene family and that at least two separate but related HSF proteins regulate the stress response in humans. ..
  28. Meng X, Chen X, Lu P, Ma W, Yue D, Song L, et al. miR-202 Promotes Cell Apoptosis in Esophageal Squamous Cell Carcinoma by Targeting HSF2. Oncol Res. 2017;25:215-223 pubmed publisher
    ..We then identified HSF2 as a direct target of miR-202 with the binding site on the 3'-UTR of HSF2 mRNA in ESCC cells...
  29. Zheng J, Guo S, Yuan S, Xia H, Zhu Q, Lv Z. Preheating mitigates cadmium toxicity in zebrafish livers: Evidence from promoter demethylation, gene transcription to biochemical levels. Aquat Toxicol. 2017;190:104-111 pubmed publisher
    ..dismutase (Cu/Zn-SOD), and up-regulated mRNA levels of heat shock protein 70 (HSP70) and heat shock factor 2 (HSF2)...
  30. Kuo C, Pai P, Ho T, Lin Y, Chen R, Tsai F, et al. Inhibition of HSF2 SUMOylation via MEL18 upregulates IGF-IIR and leads to hypertension-induced cardiac hypertrophy. Int J Cardiol. 2018;257:283-290 pubmed publisher
    ..In this study, we found that heat shock transcription factor 2 (HSF2) activated IGF-IIR to induce cardiac hypertrophy for hypertension-induced heart failure...
  31. Yoshima T, Yura T, Yanagi H. Novel testis-specific protein that interacts with heat shock factor 2. Gene. 1998;214:139-46 pubmed
    Although heat shock factor 2 (HSF2) binds to heat shock element (HSE) constitutively during differentiation, development and spermatogenesis, little is known about the nature and mechanism of transcriptional control of heat shock genes by ..
  32. Goodson M, Hong Y, Rogers R, Matunis M, Park Sarge O, Sarge K. Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor. J Biol Chem. 2001;276:18513-8 pubmed
    Heat shock transcription factor 2 (HSF2) is a transcription factor that regulates heat shock protein gene expression, but the mechanisms regulating the function of this factor are unclear...
  33. Roccisana J, Kawanabe N, Kajiya H, Koide M, Roodman G, Reddy S. Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells. J Biol Chem. 2004;279:10500-7 pubmed
    ..These data further suggest that HSF-2 is a downstream target of b-FGF to induce RANKL expression in stromal/osteoblast cells, and that HSF may play an important role in modulating RANKL gene expression in the bone microenvironment. ..
  34. Mou L, Wang Y, Li H, Huang Y, Jiang T, Huang W, et al. A dominant-negative mutation of HSF2 associated with idiopathic azoospermia. Hum Genet. 2013;132:159-65 pubmed publisher
    Idiopathic azoospermia (IA) is a severe form of male infertility due to unknown causes. The HSF2 gene, encoding the heat shock transcription factor 2, had been suggested to play a significant role in the spermatogenesis process since the ..
  35. Wilkerson D, Skaggs H, Sarge K. HSF2 binds to the Hsp90, Hsp27, and c-Fos promoters constitutively and modulates their expression. Cell Stress Chaperones. 2007;12:283-90 pubmed
    ..Previously, we reported a role for the DNA-binding protein heat shock factor (HSF2) in bookmarking the stress-inducible 70,000-Da heat shock protein (hsp70) gene...
  36. Zhao S, Guo S, Zhu Q, Yuan S, Zheng J. Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish Shellfish Immunol. 2018;72:1-8 pubmed publisher
    ..activity levels of Cu/Zn-SOD, CAT and iNOS, MTs protein levels, and mRNA levels of Nrf2, Cu/Zn-SOD, CAT, HSF1, HSF2, HSP70, MTF-1, MTs, IL-6, IL-10, IL-1?, TNF-?, iNOS and NF-?B...
  37. Björk J, Åkerfelt M, Joutsen J, Puustinen M, Cheng F, Sistonen L, et al. Heat-shock factor 2 is a suppressor of prostate cancer invasion. Oncogene. 2016;35:1770-84 pubmed publisher
    ..Although HSF1 has been identified as a driver of carcinogenesis, HSF2 has not been explored in malignancies...
  38. Zhu Q, Guo S, Yuan S, Lv Z, Zheng J, Xia H. Heat indicators of oxidative stress, inflammation and metal transport show dependence of cadmium pollution history in the liver of female zebrafish. Aquat Toxicol. 2017;191:1-9 pubmed publisher
    ..and iNOS; LPO; MT protein), 8 molecular indicators of oxidative stress (mRNA levels of Nrf2, Cu/Zn-SOD, CAT, HSF1, HSF2, HSP70, MTF-1 and MT), 5 molecular indicators of inflammation (mRNA levels of IL-6, IL-1?, TNF-?, iNOS and NF-?B), ..
  39. Walsh D, Li Z, Wu Y, Nagata K. Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development. Cell Mol Life Sci. 1997;53:198-211 pubmed
    ..embryonic cells but appears not to bind to the HSE until early head fold stage at gastrulation when the presence of HSF2 is observed...
  40. Yoshima T, Yura T, Yanagi H. The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62. Biochem Biophys Res Commun. 1997;240:228-33 pubmed
    Heat shock factor 2 (HSF2) acquires DNA binding activity during hemin-induced differentiation of human K562 erythroleukemia cells...
  41. Sheldon L, Kingston R. Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2. Genes Dev. 1993;7:1549-58 pubmed
    b>HSF2, one of the heat shock transcription factors in mammalian cells, is localized to the cytoplasm during normal growth and moves to the nucleus upon activation...
  42. Xing H, Hong Y, Sarge K. Identification of the PP2A-interacting region of heat shock transcription factor 2. Cell Stress Chaperones. 2007;12:192-7 pubmed
    ..work in our laboratory demonstrated the existence of an association between heat shock transcription factor 2 (HSF2) and the serine/threonine phosphatase 2A, which is mediated by interaction between HSF2 and the A subunit (also ..
  43. Anckar J, Hietakangas V, Denessiouk K, Thiele D, Johnson M, Sistonen L. Inhibition of DNA binding by differential sumoylation of heat shock factors. Mol Cell Biol. 2006;26:955-64 pubmed
    ..of highly similar loop structures within the DNA-binding domains of heat shock transcription factor 1 (HSF1) and HSF2. Site-specific mutagenesis in combination with molecular modeling revealed that the sumoylation specificity is ..
  44. Murphy L, Wilkerson D, Hong Y, Sarge K. PRC1 associates with the hsp70i promoter and interacts with HSF2 during mitosis. Exp Cell Res. 2008;314:2224-30 pubmed publisher
    ..b>HSF2 is a DNA binding protein that we previously showed bookmarks the hsp70i gene during mitosis, an epigenetic ..
  45. Hong Y, Sarge K. Regulation of protein phosphatase 2A activity by heat shock transcription factor 2. J Biol Chem. 1999;274:12967-70 pubmed
    ..Here, it is shown that a member of the HSF family, HSF2, interacts with the PR65 (A) subunit of protein phosphatase 2A (PP2A)...
  46. Park S, Kim S, Ahn S. HSF2 autoregulates its own transcription. Int J Mol Med. 2015;36:1173-9 pubmed publisher
    Heat shock factor 2 (HSF2) is one of the most important regulators affecting stress mechanisms, and is frequently amplified in the ubiquitin proteasome pathway...
  47. Springelkamp H, Höhn R, Mishra A, Hysi P, Khor C, Loomis S, et al. Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process. Nat Commun. 2014;5:4883 pubmed publisher
    ..This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition. ..
  48. Jin X, Eroglu B, Moskophidis D, Mivechi N. Targeted Deletion of Hsf1, 2, and 4 Genes in Mice. Methods Mol Biol. 2018;1709:1-22 pubmed publisher
    ..There are at least five Hsfs in mammalian cells, Hsf1, Hsf2, Hsf3, Hsf4, and Hsfy (Wu, Annu Rev Cell Dev Biol 11:441-469, 1995; Morimoto, Genes Dev 12:3788-3796, 1998; Tessari ..
  49. Liu Q, Lei Z, Dai M, Wang X, Yuan Z. Toxic metabolites, Sertoli cells and Y chromosome related genes are potentially linked to the reproductive toxicity induced by mequindox. Oncotarget. 2017;8:87512-87528 pubmed publisher
    ..Additionally, the changed levels of Y chromosome microdeletion related genes, such as DDX3Y, HSF2, Sly and Ssty2 in the testis might be a mechanism for the inhibition of spermatogenesis induced by MEQ...
  50. Hayashida N. Set1/MLL complex is indispensable for the transcriptional ability of heat shock transcription factor 2. Biochem Biophys Res Commun. 2015;467:805-12 pubmed publisher
    Heat shock transcription factor 2 (HSF2) is one of four mammalian HSFs, and it is essential in neurogenesis and gametogenesis. However, other aspects of this transcription factor have not been thoroughly characterized...
  51. Pai P, Kuo C, Ho T, Lin J, Lin D, Tsai F, et al. p53-mediated miR-18 repression activates HSF2 for IGF-IIR-dependent myocyte hypertrophy in hypertension-induced heart failure. Cell Death Dis. 2017;8:e2990 pubmed publisher
    ..However, the role of heat shock factor 2 (HSF2) in hypertension-induced cardiac hypertrophy is unknown...
  52. Jaeger A, Pemble C, Sistonen L, Thiele D. Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors. Nat Struct Mol Biol. 2016;23:147-54 pubmed publisher
    ..We present crystal structures of the human HSF2 DNA-binding domain (DBD) bound to DNA, revealing an unprecedented view of HSFs that provides insights into their ..
  53. Nykanen P, Alastalo T, Ahlskog J, Horelli Kuitunen N, Pirkkala L, Sistonen L. Genomic organization and promoter analysis of the human heat shock factor 2 gene. Cell Stress Chaperones. 2001;6:377-85 pubmed
    Heat shock factor 2 (HSF2) is a member of the heat shock transcription factor family, which appears to be activated during differentiation and development rather than on cellular stress...
  54. He H, Soncin F, Grammatikakis N, Li Y, Siganou A, Gong J, et al. Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress. J Biol Chem. 2003;278:35465-75 pubmed
    Heat shock factor 2 (HSF2) belongs to a family of structurally related transcription factors, which share the property of binding to heat shock elements in the promoters of hsp molecular chaperone genes...
  55. Elsing A, Aspelin C, Björk J, Bergman H, Himanen S, Kallio M, et al. Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival. J Cell Biol. 2014;206:735-49 pubmed publisher
    ..Hsps are transcriptionally regulated by heat shock factors (HSFs). Of these, HSF1 is the master regulator and HSF2 modulates Hsp expression by interacting with HSF1...
  56. Rossi A, Riccio A, Coccia M, Trotta E, La Frazia S, Santoro M. The proteasome inhibitor bortezomib is a potent inducer of zinc finger AN1-type domain 2a gene expression: role of heat shock factor 1 (HSF1)-heat shock factor 2 (HSF2) heterocomplexes. J Biol Chem. 2014;289:12705-15 pubmed publisher
    ..protein is detected at high levels for at least 48 h after bortezomib exposure, together with the accumulation of HSF2, a factor implicated in differentiation and development regulation...
  57. Kim S, Yoon J, Ahn S. Heat shock factor 4a (HSF4a) represses HSF2 expression and HSF2-mediated transcriptional activity. J Cell Physiol. 2012;227:1-6 pubmed publisher
    ..b>HSF2, which is one of the HSFs, is activated during differentiation and development but it is unclear how they regulate ..
  58. Chen R, Liliental J, Kowalski P, Lu Q, Cohen S. Regulation of transcription of hypoxia-inducible factor-1? (HIF-1?) by heat shock factors HSF2 and HSF4. Oncogene. 2011;30:2570-80 pubmed publisher
    ..We further demonstrate that HSF2 and HSF4 displace each other from HSF/HSE complexes in the HIF-1? promoter so that HIF-1? transcription is also ..
  59. Xing H, Hong Y, Sarge K. PEST sequences mediate heat shock factor 2 turnover by interacting with the Cul3 subunit of the Cul3-RING ubiquitin ligase. Cell Stress Chaperones. 2010;15:301-8 pubmed publisher
    ..Here we show that the PEST sequences of a short-lived protein called HSF2 interact with Cullin3, a subunit of a Cullin-RING E3 ubiquitin ligase, and that this interaction mediates the Cul3-..
  60. Feng H, Wang S, Guo L, Punekar A, Ladenstein R, Wang D, et al. MD simulation of high-resolution X-ray structures reveals post-translational modification dependent conformational changes in HSF-DNA interaction. Protein Cell. 2016;7:916-920 pubmed publisher
  61. Pack C, Ahn S. Heat shock-induced interactions among nuclear HSFs detected by fluorescence cross-correlation spectroscopy. Biochem Biophys Res Commun. 2015;463:303-8 pubmed publisher
    ..A previous study demonstrated that nuclear HSF1 and HSF2 molecules in live cells interacted with target DNAs on the stress granules...
  62. Miao J, Niu J, Wang K, Xiao Y, Du Y, Zhou L, et al. Heat shock factor 2 levels are associated with the severity of ulcerative colitis. PLoS ONE. 2014;9:e88822 pubmed publisher
    ..The expression of heat shock factor 2(HSF2)in colonic mucosa in Crohn's disease, Behcet's disease, ulcerative colitis, intestinal tuberculosis, infective ..
  63. Tateishi Y, Ariyoshi M, Igarashi R, Hara H, Mizuguchi K, Seto A, et al. Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2. J Biol Chem. 2009;284:2435-47 pubmed publisher
    Heat shock factor 2 (HSF2) is a member of a vertebrate transcription factor family for genes of heat shock proteins and is involved in the regulation of development and cellular differentiation...