HSF1

Summary

Gene Symbol: HSF1
Description: heat shock transcription factor 1
Alias: HSTF1, heat shock factor protein 1
Species: human
Products:     HSF1

Top Publications

  1. Hietakangas V, Ahlskog J, Jakobsson A, Hellesuo M, Sahlberg N, Holmberg C, et al. Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1. Mol Cell Biol. 2003;23:2953-68 pubmed
    ..Hsp induction is mainly regulated at transcriptional level by stress-inducible heat shock factor 1 (HSF1)...
  2. Yoon Y, Kim J, Shin K, Shin D, Han Y, Lee Y, et al. KRIBB11 inhibits HSP70 synthesis through inhibition of heat shock factor 1 function by impairing the recruitment of positive transcription elongation factor b to the hsp70 promoter. J Biol Chem. 2011;286:1737-47 pubmed publisher
    Heat shock factor 1 (HSF1) is the master switch for heat shock protein (HSP) expression in eukaryotes...
  3. Yang J, Bridges K, Chen K, Liu A. Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. PLoS ONE. 2008;3:e2864 pubmed publisher
    ..Immuno-Western and -cytochemical analysis of HSF1 show that riluzole increased the amount of cytosolic HSF1 to afford a greater activation of HSF1 upon heat shock...
  4. Page T, Sikder D, Yang L, Pluta L, Wolfinger R, Kodadek T, et al. Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival. Mol Biosyst. 2006;2:627-39 pubmed
    Although HSF1 plays an important role in the cellular response to proteotoxic stressors, little is known about the structure and function of the human HSF1 signaling network under both stressed and unstressed conditions...
  5. Kim G, Meriin A, Gabai V, Christians E, Benjamin I, Wilson A, et al. The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype. Aging Cell. 2012;11:617-27 pubmed publisher
    ..was associated with inhibition of both activity and transcription of the heat shock transcription factor Hsf1. This inhibition in large part resulted from the downregulation of SIRT1, which in turn was because of decrease in ..
  6. Nunes S, Calderwood S. Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells. Biochem Biophys Res Commun. 1995;213:1-6 pubmed
    ..These experiments show a profound effect of heat shock on the structure and stability of HSF-1 complexes during nuclear localization and support the hypothesis that HSC70 binding may control HSF-1 function. ..
  7. Whitesell L, Lindquist S. Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets. 2009;13:469-78 pubmed
    In mammals, the cytoprotective heat-shock response is regulated primarily by heat shock factor 1 (HSF1)...
  8. Knauf U, Newton E, Kyriakis J, Kingston R. Repression of human heat shock factor 1 activity at control temperature by phosphorylation. Genes Dev. 1996;10:2782-93 pubmed
    Human heat shock transcription factor 1 (HSF1) is responsible for stress-induced transcription of heat shock protein genes...
  9. Xia W, Guo Y, Vilaboa N, Zuo J, Voellmy R. Transcriptional activation of heat shock factor HSF1 probed by phosphopeptide analysis of factor 32P-labeled in vivo. J Biol Chem. 1998;273:8749-55 pubmed
    Mapping of tryptic phosphopeptides of heat shock factor 1 (HSF1) from non-stressed or moderately heat-stressed HeLa cells, labeled in vivo by [32P]orthophosphate, revealed four major phosphopeptides A to D...

More Information

Publications77

  1. Tchenio T, Havard M, Martinez L, Dautry F. Heat shock-independent induction of multidrug resistance by heat shock factor 1. Mol Cell Biol. 2006;26:580-91 pubmed
    ..confer constitutive doxorubicin resistance has in both cases resulted in the isolation of the heat shock factor 1 (HSF1) transcription factor...
  2. Guettouche T, Boellmann F, Lane W, Voellmy R. Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress. BMC Biochem. 2005;6:4 pubmed
    Heat shock factor (HSF/HSF1) not only is the transcription factor primarily responsible for the transcriptional response of cells to physical and chemical stress but also coregulates other important signaling pathways...
  3. Batista Nascimento L, Neef D, Liu P, Rodrigues Pousada C, Thiele D. Deciphering human heat shock transcription factor 1 regulation via post-translational modification in yeast. PLoS ONE. 2011;6:e15976 pubmed publisher
    Heat shock transcription factor 1 (HSF1) plays an important role in the cellular response to proteotoxic stresses...
  4. Lin P, Simon S, Koh W, Folorunso O, Umbaugh C, Pierce A. Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener. 2013;8:43 pubmed publisher
    ..homeostasis in ALS, we crossed SOD1 H46R/H48Q mutant mice with mice over-expressing the heat shock factor 1 (HSF1) transcription factor...
  5. Zuo J, Baler R, Dahl G, Voellmy R. Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure. Mol Cell Biol. 1994;14:7557-68 pubmed
  6. Mendillo M, Santagata S, Koeva M, Bell G, Hu R, Tamimi R, et al. HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell. 2012;150:549-62 pubmed publisher
    Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival, and proliferation in model systems...
  7. Liu A, Mathur R, Mei N, Langhammer C, Babiarz B, Firestein B. Neuroprotective drug riluzole amplifies the heat shock factor 1 (HSF1)- and glutamate transporter 1 (GLT1)-dependent cytoprotective mechanisms for neuronal survival. J Biol Chem. 2011;286:2785-94 pubmed publisher
    Heat shock factor 1 (HSF1) mediates the cellular response to stress to increase the production of heat shock protein (HSP) chaperones for proper protein folding, trafficking, and degradation; failure of this homeostatic mechanism likely ..
  8. Santagata S, Hu R, Lin N, Mendillo M, Collins L, Hankinson S, et al. High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A. 2011;108:18378-83 pubmed publisher
    Heat-shock factor 1 (HSF1) is the master transcriptional regulator of the cellular response to heat and a wide variety of other stressors. We previously reported that HSF1 promotes the survival and proliferation of malignant cells...
  9. Wang X, Khaleque M, Zhao M, Zhong R, Gaestel M, Calderwood S. Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding. J Biol Chem. 2006;281:782-91 pubmed
    Heat shock transcription factor 1 (HSF1) monitors the structural integrity of intracellular proteins and its regulation is essential for the health and longevity of eukaryotic organisms...
  10. Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, et al. Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest. 2012;122:3742-54 pubmed publisher
    ..A striking example is heat shock factor 1 (HSF1), master transcriptional regulator of the heat shock response...
  11. Rawat P, Mitra D. Cellular heat shock factor 1 positively regulates human immunodeficiency virus-1 gene expression and replication by two distinct pathways. Nucleic Acids Res. 2011;39:5879-92 pubmed publisher
    ..As expression of HSPs is regulated by heat shock factors (HSFs), we have now studied the role of HSF1 not only in Nef-dependent HSP40 induction but also in HIV-1 gene expression...
  12. Wang Y, Theriault J, He H, Gong J, Calderwood S. Expression of a dominant negative heat shock factor-1 construct inhibits aneuploidy in prostate carcinoma cells. J Biol Chem. 2004;279:32651-9 pubmed
    Recent studies have implicated heat shock proteins (HSP) and heat shock transcription factor 1 (HSF1) in tumor progression. We have examined the role of HSF1 in the malignant phenotype of PC-3 prostate carcinoma cells...
  13. Wang X, Grammatikakis N, Siganou A, Calderwood S. Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1. Mol Cell Biol. 2003;23:6013-26 pubmed
    Heat shock factor 1 (HSF1) regulates the transcription of molecular chaperone hsp genes. However, the cellular control mechanisms that regulate HSF1 activity are not well understood...
  14. Shamovsky I, Ivannikov M, Kandel E, Gershon D, Nudler E. RNA-mediated response to heat shock in mammalian cells. Nature. 2006;440:556-60 pubmed
    The heat-shock transcription factor 1 (HSF1) has an important role in the heat-shock response in vertebrates by inducing the expression of heat-shock proteins (HSPs) and other cytoprotective proteins...
  15. Wang F, Wu X, Liu W, Liao Y, Lin S, Zong Y, et al. Heat shock factor 1 upregulates transcription of Epstein-Barr Virus nuclear antigen 1 by binding to a heat shock element within the BamHI-Q promoter. Virology. 2011;421:184-91 pubmed publisher
    ..Using bioinformatics, a high affinity and functional heat shock factor 1 (HSF1)-binding element within the -17/+4 oligonucleotide of the Qp was found, and was determined by electrophoretic ..
  16. Murshid A, Chou S, Prince T, Zhang Y, Bharti A, Calderwood S. Protein kinase A binds and activates heat shock factor 1. PLoS ONE. 2010;5:e13830 pubmed publisher
    ..We have studied such regulation of Heat Shock Factor 1 (HSF1), a key protein in control of the heat shock response, and a participant in carcinogenisis, neurological health and ..
  17. Hayashida N, Fujimoto M, Tan K, Prakasam R, Shinkawa T, Li L, et al. Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. EMBO J. 2010;29:3459-69 pubmed publisher
    Heat shock transcription factor 1 (HSF1) is an important regulator of protein homeostasis (proteostasis) by controlling the expression of major heat shock proteins (Hsps) that facilitate protein folding...
  18. Chu B, Soncin F, Price B, Stevenson M, Calderwood S. Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1. J Biol Chem. 1996;271:30847-57 pubmed
  19. Jolly C, Konecny L, Grady D, Kutskova Y, Cotto J, Morimoto R, et al. In vivo binding of active heat shock transcription factor 1 to human chromosome 9 heterochromatin during stress. J Cell Biol. 2002;156:775-81 pubmed
    ..Coincident with these events is the rapid and reversible redistribution of HSF1 to discrete nuclear structures termed HSF1 granules, whose function is still unknown...
  20. Schuetz T, Gallo G, Sheldon L, Tempst P, Kingston R. Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans. Proc Natl Acad Sci U S A. 1991;88:6911-5 pubmed
    ..These peptides are encoded by a distinct human cDNA, HSF1, described by Rabindran et al. [Rabindran, S. K., Giorgi, G., Clos, J. & Wu, C. (1991) Proc. Natl. Acad. Sci...
  21. Guo Y, Guettouche T, Fenna M, Boellmann F, Pratt W, Toft D, et al. Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex. J Biol Chem. 2001;276:45791-9 pubmed
    ..This repression mechanism may be required for a proportional transcriptional response to stress. Formation of the heterocomplex may also represent the first step toward returning the hHSF1 to its unactivated form. ..
  22. Shi Y, Mosser D, Morimoto R. Molecular chaperones as HSF1-specific transcriptional repressors. Genes Dev. 1998;12:654-66 pubmed
    The rapid yet transient transcriptional activation of heat shock genes is mediated by the reversible conversion of HSF1 from an inert negatively regulated monomer to a transcriptionally active DNA-binding trimer...
  23. Dudeja V, Chugh R, Sangwan V, Skube S, Mujumdar N, Antonoff M, et al. Prosurvival role of heat shock factor 1 in the pathogenesis of pancreatobiliary tumors. Am J Physiol Gastrointest Liver Physiol. 2011;300:G948-55 pubmed publisher
    ..The heat shock response is one such evolutionarily conserved survival mechanism. Heat shock factor-1 (HSF1) is a transcriptional regulator of the heat shock response...
  24. Westerheide S, Anckar J, Stevens S, Sistonen L, Morimoto R. Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1. Science. 2009;323:1063-6 pubmed publisher
    Heat shock factor 1 (HSF1) is essential for protecting cells from protein-damaging stress associated with misfolded proteins and regulates the insulin-signaling pathway and aging...
  25. Jolly C, Usson Y, Morimoto R. Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules. Proc Natl Acad Sci U S A. 1999;96:6769-74 pubmed
    Heat shock factor 1 (HSF1) is essential for the stress-induced expression of heat shock genes. On exposure to heat shock, HSF1 localizes within seconds to discrete nuclear granules...
  26. Kim S, Yoon J, Kim D, Kim S, Ahn S. CHIP interacts with heat shock factor 1 during heat stress. FEBS Lett. 2005;579:6559-63 pubmed
    Heat shock factor 1 (HSF1) is a major transactivator of heat shock genes in response to stress and mediates cell protection against various harmful conditions...
  27. Fujimoto M, Takaki E, Hayashi T, Kitaura Y, Tanaka Y, Inouye S, et al. Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. J Biol Chem. 2005;280:34908-16 pubmed
    ..Here, we examined the impact of active forms of heat shock transcription factor 1 (HSF1), which induces a set of Hsps, on polyglutamine inclusion formation and disease progression...
  28. Xie Y, Chen C, Stevenson M, Auron P, Calderwood S. Heat shock factor 1 represses transcription of the IL-1beta gene through physical interaction with the nuclear factor of interleukin 6. J Biol Chem. 2002;277:11802-10 pubmed
    ..Following our previous study, which demonstrated the transcriptional repression of the IL-1beta gene by HSF1 (Cahill, C. M., Waterman, W. R., Xie, Y., Auron, P. E., and Calderwood, S. K. (1996) J. Biol. Chem...
  29. Ishiwata J, Kasamatsu A, Sakuma K, Iyoda M, Yamatoji M, Usukura K, et al. State of heat shock factor 1 expression as a putative diagnostic marker for oral squamous cell carcinoma. Int J Oncol. 2012;40:47-52 pubmed publisher
    Heat shock factor 1 (HSF1) is responsible for expres-- sion of a large class of heat shock proteins that have been implicated in the malignant phenotype of human cancers...
  30. Wang J, Yao M, Gu J, Sun L, Shen Y, Liu X. Blocking HSF1 by dominant-negative mutant to sensitize tumor cells to hyperthermia. Biochem Biophys Res Commun. 2002;290:1454-61 pubmed
    ..In the present study, we inhibited the expression of HSP70 by blocking the heat shock transcription factor 1 (HSF1) function with its dominant-negative mutant (mHSF1) in Bcap37 cells, a thermotolerant breast cancer cell line...
  31. Fang F, Chang R, Yang L. Heat shock factor 1 promotes invasion and metastasis of hepatocellular carcinoma in vitro and in vivo. Cancer. 2012;118:1782-94 pubmed publisher
    Heat shock factor 1 (HSF1) is a powerful, multifaceted modifier of carcinogenesis. However, the clinical significance and biologic function of HSF1 in hepatocellular carcinoma (HCC) remain unknown...
  32. Desai S, Liu Z, Yao J, Patel N, Chen J, Wu Y, et al. Heat shock factor 1 (HSF1) controls chemoresistance and autophagy through transcriptional regulation of autophagy-related protein 7 (ATG7). J Biol Chem. 2013;288:9165-76 pubmed publisher
    Heat shock factor 1 (HSF1), a master regulator of heat shock responses, plays an important role in tumorigenesis...
  33. Santagata S, Mendillo M, Tang Y, Subramanian A, Perley C, Roche S, et al. Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science. 2013;341:1238303 pubmed publisher
    ..transcriptional effect of blocking protein translation in cancer cells was inactivation of heat shock factor 1 (HSF1), a multifaceted transcriptional regulator of the heat-shock response and many other cellular processes essential ..
  34. Green M, Schuetz T, Sullivan E, Kingston R. A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function. Mol Cell Biol. 1995;15:3354-62 pubmed
    Human heat shock factor 1 (HSF1) stimulates transcription from heat shock protein genes following stress...
  35. Steele A, Hutter G, Jackson W, Heppner F, Borkowski A, King O, et al. Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A. 2008;105:13626-31 pubmed publisher
    ..We hypothesized that the transcriptional regulator of the stress response, heat shock factor 1 (HSF1), would play an important role in prion disease...
  36. Rossi A, Trotta E, Brandi R, Arisi I, Coccia M, Santoro M. AIRAP, a new human heat shock gene regulated by heat shock factor 1. J Biol Chem. 2010;285:13607-15 pubmed publisher
    Heat shock factor-1 (HSF1) is the central regulator of heat-induced transcriptional responses leading to rapid expression of molecular chaperones that protect mammalian cells against proteotoxic stress...
  37. Neef D, Turski M, Thiele D. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010;8:e1000291 pubmed publisher
    ..protein chaperones suppress polyQ protein misfolding, the master regulator of protein chaperone gene transcription, HSF1, is an attractive target for small molecule intervention...
  38. Cotto J, Fox S, Morimoto R. HSF1 granules: a novel stress-induced nuclear compartment of human cells. J Cell Sci. 1997;110 ( Pt 23):2925-34 pubmed
    Heat shock factor 1 (HSF1) is the ubiquitous stress-responsive transcriptional activator which is essential for the inducible transcription of genes encoding heat shock proteins and molecular chaperones...
  39. Dai C, Whitesell L, Rogers A, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell. 2007;130:1005-18 pubmed
    Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserved protective mechanism. HSF1 function increases survival under a great many pathophysiological conditions...
  40. Maity T, Henry M, Tulapurkar M, Shah N, Hasday J, Singh I. Distinct, gene-specific effect of heat shock on heat shock factor-1 recruitment and gene expression of CXC chemokine genes. Cytokine. 2011;54:61-7 pubmed publisher
    ..Our earlier studies showed that the stress-activated transcription factor, heat shock factor-1 (HSF1), activated at febrile range or HS temperatures also modified expression of non-HSP genes including cytokine and ..
  41. Pierce A, Podlutskaya N, Halloran J, Hussong S, Lin P, Burbank R, et al. Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease. J Neurochem. 2013;124:880-93 pubmed publisher
    ..Read the Editorial Highlight for this article on doi: 10.1111/jnc.12098. ..
  42. Holmberg C, Hietakangas V, Mikhailov A, Rantanen J, Kallio M, Meinander A, et al. Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1. EMBO J. 2001;20:3800-10 pubmed
    Heat shock factor 1 (HSF1) is a serine-rich constitutively phosphorylated mediator of the stress response...
  43. Wang X, Grammatikakis N, Siganou A, Stevenson M, Calderwood S. Interactions between extracellular signal-regulated protein kinase 1, 14-3-3epsilon, and heat shock factor 1 during stress. J Biol Chem. 2004;279:49460-9 pubmed
    ..have examined the interaction of two key molecular components in the response, heat shock transcription factor 1 (HSF1) and extracellular signal regulated protein kinase (ERK)...
  44. Chou S, Prince T, Gong J, Calderwood S. mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis. PLoS ONE. 2012;7:e39679 pubmed publisher
    ..As HSP transcription is regulated by heat shock transcription factor 1 (HSF1), we examined whether mTOR could directly phosphorylate this factor...
  45. Abravaya K, Myers M, Murphy S, Morimoto R. The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression. Genes Dev. 1992;6:1153-64 pubmed
    ..We suggest that hsp70 may negatively regulate the activation of HSF. ..
  46. Raychaudhuri S, Loew C, Körner R, Pinkert S, Theis M, Hayer Hartl M, et al. Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1. Cell. 2014;156:975-85 pubmed publisher
    ..A key feature of this response is the heat shock transcription factor 1 (HSF1)-dependent expression of molecular chaperones...
  47. Rabindran S, Giorgi G, Clos J, Wu C. Molecular cloning and expression of a human heat shock factor, HSF1. Proc Natl Acad Sci U S A. 1991;88:6906-10 pubmed
    ..We have isolated recombinant DNA clones for a human HSF (HSF1) by screening cDNA libraries with a human cDNA fragment...
  48. Baler R, Zou J, Voellmy R. Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells. Cell Stress Chaperones. 1996;1:33-9 pubmed
    ..insults (stress) cause unfolding of proteins, triggering the activation of heat shock transcription factor HSF (HSF1 in vertebrates) that, in higher eukaryotes, involves trimerization of the factor and acquisition of heat shock ..
  49. Xie Y, Zhong R, Chen C, Calderwood S. Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes. J Biol Chem. 2003;278:4687-98 pubmed
    Heat shock factor 1 (HSF1), in addition to its pivotal role as a regulator of the heat shock response, functions as a versatile gene repressor...
  50. Ignatenko N, Gerner E. Regulation of the HIV1 long terminal repeat by mutant heat shock factor. Exp Cell Res. 2003;288:1-8 pubmed
    ..luciferase constructs were generated and tested in cell culture in combination with a mutant heat shock factor 1 (HSF1+), which is transcriptionally active in the absence of heat stress...
  51. Hong S, Kim S, Heo M, Choi Y, Park M, Yoo M, et al. Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock. FEBS Lett. 2004;559:165-70 pubmed
    ..cells increase the expression of the heat shock proteins (HSP) through activation of the heat shock factor 1 (HSF1)...
  52. Sandqvist A, Björk J, Akerfelt M, Chitikova Z, Grichine A, Vourc h C, et al. Heterotrimerization of heat-shock factors 1 and 2 provides a transcriptional switch in response to distinct stimuli. Mol Biol Cell. 2009;20:1340-7 pubmed publisher
    ..Of the four HSFs in vertebrates (HSF1-4), HSF1 is activated by stress, whereas HSF2 lacks intrinsic stress responsiveness...
  53. Chen C, Xie Y, Stevenson M, Auron P, Calderwood S. Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene. J Biol Chem. 1997;272:26803-6 pubmed
  54. Zou J, Guo Y, Guettouche T, Smith D, Voellmy R. Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell. 1998;94:471-80 pubmed
    ..In a novel in vitro system, in which human HSF1 can be activated by nonnative protein, heat, and geldanamycin, addition of Hsp90 inhibits activation...
  55. Hu Y, Mivechi N. HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo. J Biol Chem. 2003;278:17299-306 pubmed
    Heat shock factor 1 (HSF1) regulates the rapid and transient expression of heat shock genes in response to stress...
  56. Soncin F, Zhang X, Chu B, Wang X, Asea A, Ann Stevenson M, et al. Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2. Biochem Biophys Res Commun. 2003;303:700-6 pubmed
    ..As HSF1 is activated by heat shock simultaneously with the nuclear translocation of the protein kinase CK2, we have ..
  57. Santon A, Garcia Cosio M, Cristobal E, Pascual A, Muriel A, García Laraña J. Expression of heat shock proteins in classical Hodgkin lymphoma: correlation with apoptotic pathways and prognostic significance. Histopathology. 2011;58:1072-80 pubmed publisher
    ..We analysed the expression of relevant HSPs and heat shock factor 1 (HSF1) in classical Hodgkin lymphoma (cHL) and their relationship with caspase signalling pathways and patient outcome...
  58. Vujanac M, Fenaroli A, Zimarino V. Constitutive nuclear import and stress-regulated nucleocytoplasmic shuttling of mammalian heat-shock factor 1. Traffic. 2005;6:214-29 pubmed
    ..expression of major cytosolic and nuclear chaperone proteins is mediated by the heat-shock transcription factor HSF1 that is activated by derepressive mechanisms triggered by transient heat stress and sustained proteotoxicity...
  59. Liang D, Benko Z, Agbottah E, Bukrinsky M, Zhao R. Anti-vpr activities of heat shock protein 27. Mol Med. 2007;13:229-39 pubmed
    ..Together, these data suggest a potential dynamic and antagonistic interaction between HIV-1 Vpr and a host cell HSP27, suggesting that HSP27 may contribute to cellular intrinsic immunity against HIV infection. ..
  60. Khaleque M, Bharti A, Gong J, Gray P, Sachdev V, Ciocca D, et al. Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1. Oncogene. 2008;27:1886-93 pubmed
    Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer...
  61. Wang J, Yao M, Zhang Z, Zhang Y, Wang Y, Liu X. HSF1 blockade-induced tumor thermotolerance abolishment is mediated by JNK-dependent caspase-3 activation. Biochem Biophys Res Commun. 2004;321:736-45 pubmed
    ..Our results suggest that mHSF1 plays a valuable role in the thermotolerance abolishment of Bcap37 cells, which likely contributes to tumor therapy in combination with hyperthermia. ..
  62. Alastalo T, Hellesuo M, Sandqvist A, Hietakangas V, Kallio M, Sistonen L. Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70. J Cell Sci. 2003;116:3557-70 pubmed
    The heat-shock response is characterized by the activation of heat-shock transcription factor 1 (HSF1), followed by increased expression of heat-shock proteins (Hsps)...
  63. Rossi A, Coccia M, Trotta E, Angelini M, Santoro M. Regulation of cyclooxygenase-2 expression by heat: a novel aspect of heat shock factor 1 function in human cells. PLoS ONE. 2012;7:e31304 pubmed publisher
    ..In humans HSF1 is considered the central regulator of heat-induced transcriptional responses...
  64. Östling P, Björk J, Roos Mattjus P, Mezger V, Sistonen L. Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1. J Biol Chem. 2007;282:7077-86 pubmed
    ..Mammalian HSF1 was originally identified as the transcriptional regulator of the heat shock response, whereas HSF2 has not been ..
  65. Dai R, Frejtag W, He B, Zhang Y, Mivechi N. c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity. J Biol Chem. 2000;275:18210-8 pubmed
    ..Taken together, these findings indicate that JNK phosphorylates HSF-1 and suppresses its transcriptional activity by rapidly clearing HSF-1 from the sites of transcription. ..
  66. Reinke H, Saini C, Fleury Olela F, Dibner C, Benjamin I, Schibler U. Differential display of DNA-binding proteins reveals heat-shock factor 1 as a circadian transcription factor. Genes Dev. 2008;22:331-45 pubmed publisher
    ..In addition to several established circadian transcription factors, we found DNA binding of heat-shock factor 1 (HSF1) to be highly rhythmic...
  67. Kline M, Morimoto R. Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation. Mol Cell Biol. 1997;17:2107-15 pubmed
    Heat shock transcription factor 1 (HSF1) is constitutively expressed in mammalian cells and negatively regulated for DNA binding and transcriptional activity...
  68. Zhao Y, Zhou M, Liu H, Ding Y, Khong H, Yu D, et al. Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene. 2009;28:3689-701 pubmed publisher
    ..the expression of glycolysis-regulating molecules lactate dehydrogenase A (LDH-A) and heat shock factor 1 (HSF1). ErbB2 activated HSF1, indicated by the increased HSF1 trimer formation, and promoted HSF1 protein synthesis...