HSD3B1

Summary

Gene Symbol: HSD3B1
Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Alias: 3BETAHSD, HSD3B, HSDB3, HSDB3A, SDR11E1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, delta-5-3-ketosteroid isomerase, progesterone reductase, short chain dehydrogenase/reductase family 11E, member 1, steroid Delta-isomerase, trophoblast antigen FDO161G
Species: human

Top Publications

  1. ncbi Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase
    James L Thomas
    Division of Basic Medical Sciences and Department of Obstetrics Gynecology, Mercer University School of Medicine, Macon, Georgia 31207, USA
    J Biol Chem 278:35483-90. 2003
  2. ncbi Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin
    M Dumont
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    J Invest Dermatol 99:415-21. 1992
  3. ncbi Structural analysis of the gene encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase
    M C Lorence
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9051
    Mol Endocrinol 4:1850-5. 1990
  4. ncbi Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase
    V Luu The
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 3:1310-2. 1989
  5. ncbi Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Biochem Biophys Res Commun 293:629-32. 2002
  6. ncbi Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes
    J L Thomas
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110
    J Steroid Biochem 33:209-17. 1989
  7. ncbi Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids
    M C Lorence
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9051
    Endocrinology 126:2493-8. 1990
  8. ncbi The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency
    Goldy Carbunaru
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 89:783-94. 2004
  9. ncbi Dual subcellular localization of the 3 beta-hydroxysteroid dehydrogenase isomerase: characterization of the mitochondrial enzyme in the bovine adrenal cortex
    N Cherradi
    Unité INSERM 244, DBMS BRCE, Centre d Etudes Nucléaires, Grenoble, France
    J Steroid Biochem Mol Biol 46:773-9. 1993
  10. doi Evidence for an inhibitory role of bone morphogenetic protein(s) in the follicular-luteal transition in cattle
    Amjad R Kayani
    School of Biological Sciences, University of Reading, Whiteknights, Reading, UK
    Reproduction 137:67-78. 2009

Research Grants

  1. Ethnic difference in prostate cancer
    Timothy R Rebbeck; Fiscal Year: 2010
  2. Genes, Hormones and Breast Cancer Risk
    Veronica Wendy Setiawan; Fiscal Year: 2010
  3. PLACENTAL 3 BETA-HYDROXYSTEROID DEHYDROGENASE/ISOMERASE
    James Thomas; Fiscal Year: 2003
  4. Placental 3B-Hydroxysteroid Dehydrogenase/Isomerase
    James Thomas; Fiscal Year: 2008
  5. Rhesus-Human Adrenal Comparisons During Aging
    Charles Parker; Fiscal Year: 2002
  6. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
  7. ETIOLOGY, HORMONAL CRITERIA OF 3 BETA HSD DEFICIENCY
    Songya Pang; Fiscal Year: 2002
  8. OVARIAN LDL RECEPTOR AND STAR GENE REGULATION
    HOLLY LAVOIE; Fiscal Year: 2003
  9. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
  10. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005

Detail Information

Publications210 found, 100 shown here

  1. ncbi Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase
    James L Thomas
    Division of Basic Medical Sciences and Department of Obstetrics Gynecology, Mercer University School of Medicine, Macon, Georgia 31207, USA
    J Biol Chem 278:35483-90. 2003
    ....
  2. ncbi Characterization, expression, and immunohistochemical localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase in human skin
    M Dumont
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    J Invest Dermatol 99:415-21. 1992
    ..38 microM, 1.3 microM, and 1.2 microM, respectively. Immunohistochemical localization of 3 beta-HSD, illustrated by using an antibody raised against human placental 3 beta-HSD, shows that the enzyme is localized in sebaceous glands...
  3. ncbi Structural analysis of the gene encoding human 3 beta-hydroxysteroid dehydrogenase/delta 5----4-isomerase
    M C Lorence
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9051
    Mol Endocrinol 4:1850-5. 1990
    ..These findings will provide a foundation for the characterization of apparent 3 beta HSD clinical deficiencies when these are due to a mutation in the structural gene...
  4. ncbi Full length cDNA structure and deduced amino acid sequence of human 3 beta-hydroxy-5-ene steroid dehydrogenase
    V Luu The
    Department of Molecular Endocrinology, Laval University Medical Centre, Quebec, Canada
    Mol Endocrinol 3:1310-2. 1989
    ....
  5. ncbi Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure
    Roland Rosmond
    Department of Clinical Chemistry, Sahlgrenska University Hospital, S 413 45 Goteborg, Sweden
    Biochem Biophys Res Commun 293:629-32. 2002
    ..the present study was to examine the potential impact of a T-->C substitution at codon Leu(338) of the type I (HSD3B1) 3 beta-HSD gene on obesity, circulating hormones, and estimates of insulin, glucose, and lipid metabolism as well ..
  6. ncbi Human placental 3 beta-hydroxy-5-ene-steroid dehydrogenase and steroid 5----4-ene-isomerase: purification from mitochondria and kinetic profiles, biophysical characterization of the purified mitochondrial and microsomal enzymes
    J L Thomas
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110
    J Steroid Biochem 33:209-17. 1989
    ..These results suggest that the mitochondrial and microsomal enzymes are the same protein localized in different organelles...
  7. ncbi Human 3 beta-hydroxysteroid dehydrogenase/delta 5----4isomerase from placenta: expression in nonsteroidogenic cells of a protein that catalyzes the dehydrogenation/isomerization of C21 and C19 steroids
    M C Lorence
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas 75235 9051
    Endocrinology 126:2493-8. 1990
    ..Thus, the dehydrogenation/isomerization steps of steroid biosynthesis can be catalyzed by a single polypeptide chain, which can metabolize all of the major physiological substrates...
  8. ncbi The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency
    Goldy Carbunaru
    Department of Pediatrics, Division of Pediatric Endocrinology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 89:783-94. 2004
    To test our hypothesis that the hormonal phenotype of mild 3beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females (HF) is related to insulin-resistant polycystic ovary syndrome (PCOS), we compared insulin ..
  9. ncbi Dual subcellular localization of the 3 beta-hydroxysteroid dehydrogenase isomerase: characterization of the mitochondrial enzyme in the bovine adrenal cortex
    N Cherradi
    Unité INSERM 244, DBMS BRCE, Centre d Etudes Nucléaires, Grenoble, France
    J Steroid Biochem Mol Biol 46:773-9. 1993
    ....
  10. doi Evidence for an inhibitory role of bone morphogenetic protein(s) in the follicular-luteal transition in cattle
    Amjad R Kayani
    School of Biological Sciences, University of Reading, Whiteknights, Reading, UK
    Reproduction 137:67-78. 2009
    ..affecting expression of CYP11A1 or hydroxy-Delta-5-steroid dehydrogenase, 3 beta- and steroid Delta-isomerase 1 (HSD3B1)...
  11. ncbi Carriers for type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) deficiency can only be identified by HSD3B2 genotype study and not by hormone test
    Songya Pang
    Department of Pediatrics, University of Illinois, College of Medicine, Chicago, IL 60612, USA
    Clin Endocrinol (Oxf) 58:323-31. 2003
    ....
  12. ncbi New insight into the molecular basis of 3beta-hydroxysteroid dehydrogenase deficiency: identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional properties of twenty-five mutant enzymes
    A M Moisan
    Centre Hospitalier Université Laval Research Center and Laval University, Quebec, Canada
    J Clin Endocrinol Metab 84:4410-25. 1999
    Classical 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase (3betaHSD) deficiency is a form of congenital adrenal hyperplasia that impairs steroidogenesis in both the adrenals and gonads resulting from mutations in the HSD3B2 ..
  13. doi Activin A reduces luteinisation of human luteinised granulosa cells and has opposing effects to human chorionic gonadotropin in vitro
    Michelle Myers
    Obstetrics and Gynaecology, Department of Reproductive and Developmental Sciences, University of Edinburgh, 47 Little France Crescent, Edinburgh EH164TJ, UK
    J Endocrinol 199:201-12. 2008
    ..In addition, activin A blocked hCG upregulation of STAR, HSD3B1 and HSD11B1 and downregulation of oestrogen receptor alpha...
  14. doi Recovery of suppressed male reproduction in mice exposed to progesterone during embryonic development by testosterone
    C Harini
    Department of Biotechnology, Sri Venkateswara University, Tirupati, India
    Reproduction 137:439-48. 2009
    ..steroidogenic marker enzymes (hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase cluster (HSD3B) and hydroxysteroid (17-beta) dehydrogenase 1 (HSD17B)) decreased significantly in mice exposed to progesterone ..
  15. doi Leydig cell re-generation and expression of cell signaling molecules in the germ cell-free testis
    P J O'Shaughnessy
    Division of Cell Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, Bearsden Road, Glasgow G61 1QH, UK
    Reproduction 135:851-8. 2008
    ..enzymes cytochrome P450 11a1 (Cyp11a1), cytochrome P450 17a1 (Cyp17a1), 3beta-hydroxysteroid dehydrogenase type 1 (Hsd3b1), 17beta-hydroxysteroid dehydrogenase type 3 (Hsd17b3) and the LH receptor...
  16. ncbi The genes encoding gonadal and nongonadal forms of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase are closely linked on mouse chromosome 3
    P A Bain
    Graduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor 48109
    Genomics 16:219-23. 1993
    ..The mouse expresses four isoforms of 3 beta HSD. 3 beta HSD I is expressed in gonads and adrenal glands and appears to be the major steroidogenic form, 3 beta HSDs II and ..
  17. ncbi The expression of ovine placental lactogen, StAR and progesterone-associated steroidogenic enzymes in placentae of overnourished growing adolescent ewes
    Richard G Lea
    School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington Campus, Sutton Bonington LE12 5RD, UK
    Reproduction 133:785-96. 2007
    ..reflected transcript abundance for StAR (cholesterol transporter) and the steroidogenic enzymes (Cyp11A1, Hsd3b and Cyp17). Circulating and placental expression of ovine placental lactogen (oPL) was also investigated...
  18. pmc Di-(2 ethylhexyl) phthalate and flutamide alter gene expression in the testis of immature male rats
    Thuy T B Vo
    Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk, 361 763, Republic of Korea
    Reprod Biol Endocrinol 7:104. 2009
    ..Significant decreases in gene expression were observed in steroidogenic genes (i.e., Star, Cyp11a1 and Hsd3b)...
  19. doi DNA methylation is not involved in preovulatory down-regulation of CYP11A1, HSD3B1, and CYP19A1 in bovine follicles but may have a role in permanent silencing of CYP19A1 in large granulosa lutein cells
    Jens Vanselow
    Forschungsbereich Molekularbiologie, Forschungsinstitut fur die Biologie landwirtschaftlicher Nutztiere FBN, Dummerstorf, Germany
    Biol Reprod 82:289-98. 2010
    ..In the present study, the cell type-specific methylation profiles of CYP11A1, HSD3B1, and CYP19A1, genes that encode key enzymes of steroid hormone biosynthesis, were analyzed to elucidate whether ..
  20. doi Transforming growth factor-beta1 inhibits luteinization and promotes apoptosis in bovine granulosa cells
    Xiaofeng Zheng
    Faculte de Medecine Veterinaire, Centre de Recherche en Reproduction Animale CRRA, Universite de Montreal, Quebec, Canada
    Reproduction 137:969-77. 2009
    ..of TGFB1 for 6 days decreased P(4) secretion and mRNA levels of the P(4) synthesis-associated genes STAR, CYP11A1, HSD3B1, and GSTA (P<0.05)...
  21. doi Retinoblastoma 1 protein modulates XY germ cell entry into G1/G0 arrest during fetal development in mice
    Cassy M Spiller
    Division of Molecular Genetics and Development, and Australian Research Council Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
    Biol Reprod 82:433-43. 2010
    ..5 dpc. In Rb1(-/-) gonads, we observed normal somatic cell development, assessed by immunofluorescence for markers HSD3B1 and anti-Müllerian hormone. However, at 14...
  22. doi Expression profiling of candidate genes during ovary-to-testis trans-differentiation in rainbow trout masculinized by androgens
    Daniel Baron
    INRA, UR1037 SCRIBE, IFR140, Ouest genopole, Rennes, France
    Gen Comp Endocrinol 156:369-78. 2008
    ..was especially noticeable for many Leydig cell genes encoding proteins involved in steroidogenesis or its control (hsd3b1, star, cyp17a1, cyp11b2.1 and nr5a1b) that were down-regulated in the androgen-treated group...
  23. doi Increased posthatching mortality and loss of sexually dimorphic gene expression in alligators (Alligator mississippiensis) from a contaminated environment
    Matthew R Milnes
    Department of Zoology, University of Florida, Gainesville, Florida 32611, USA
    Biol Reprod 78:932-8. 2008
    ..cytochrome P450 11A1 (Cyp11a1), and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (Hsd3b1)...
  24. doi Fetal testis dysgenesis and compromised Leydig cell function in Tgfbr3 (beta glycan) knockout mice
    Mai A Sarraj
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Biol Reprod 82:153-62. 2010
    ..The expression levels of the Leydig cell markers Insl3, Cyp17a1, Cyp11a1, Star, and Hsd3b1 were reduced in knockout testis compared to wild-type testis, beginning at 12.5 dpc...
  25. ncbi Cloning, expression, and physical mapping of the 3beta-hydroxysteroid dehydrogenase gene cluster (HSD3BP1-HSD3BP5) in human
    M W McBride
    Institute of Biomedical and Life Sciences, Glasgow University, Glasgow, G12 8QQ, Scotland
    Genomics 61:277-84. 1999
    ..b>HSD3B1 and 2 express 3beta-HSD enzymes; HSD3Bpsi1-5 are unprocessed pseudogenes that are closely related to HSD3B1 and 2 ..
  26. ncbi Cattle and sheep use different promoters to direct the expression of the aromatase cytochrome P450 encoding gene, Cyp19, during pregnancy
    Jens Vanselow
    Research Institute for the Biology of Farm Animals, Research Unit Molecular Biology, Wilhelm Stahl Allee 2, 18196 Dummerstorf, Germany
    Domest Anim Endocrinol 27:99-114. 2004
    ..Cyp19 transcript variants, derived from different promoters, as well as transcripts of Hsd3b, Cyp11A1, and Cyp17, encoding the steroidogenic enzymes P450arom, 3beta-HSD, P450SCC, and P450C17, respectively, ..
  27. ncbi Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 75:342-51. 2006
    ..It also decreased the levels of the HSD3B, CYP11A1, STAR, and CYP19A1 proteins in response to FSH (10(-8) M) and of HSD3B in the basal state only...
  28. doi Role of transforming growth factor-beta1 in gene expression and activity of estradiol and progesterone-generating enzymes in FSH-stimulated bovine granulosa cells
    Xiaofeng Zheng
    Faculte de Medecine Veterinaire, Centre de Recherche en Reproduction Animale CRRA, Universite de Montreal, St Hyacinthe, Quebec, Canada
    Reproduction 136:447-57. 2008
    ..FSH dose did not affect P(4) secretion and mRNA expression of 3beta-hydroxysteroid dehydrogenase (HSD3B) and alpha-glutathione S-transferase (GSTA), but inhibited the amount of steroidogenic acute regulatory protein (..
  29. doi Calcitriol inhibits TNF-alpha-induced inflammatory cytokines in human trophoblasts
    Lorenza Díaz
    Department of Reproductive Biology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Vasco de Quiroga No 15, Tlalpan 14000, Mexico, D F, Mexico
    J Reprod Immunol 81:17-24. 2009
    ..The effects of TNF-alpha on CYP24A1, chorionic gonadotropin (hCG), 3beta-hydroxysteroid dehydrogenase (HSD3B1) and P(450)-aromatase (CYP19) mRNA expression were also studied...
  30. ncbi Molecular biology of the 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase gene family
    Jacques Simard
    Cancer Genomics Laboratory, T3 57, Laval University Medical Center CHUL Research Center, 2705 Laurier Boulevard, Quebec City, Quebec, Canada
    Endocr Rev 26:525-82. 2005
    ..It was shown that epidermal growth factor (EGF) requires intact STAT5; on the other hand IL-4 induces HSD3B1 gene expression, along with IL-13, through STAT 6 activation...
  31. ncbi Evaluation of genetic variations in the androgen and estrogen metabolic pathways as risk factors for sporadic and familial prostate cancer
    Julie M Cunningham
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Cancer Epidemiol Biomarkers Prev 16:969-78. 2007
    ..Those genes tested included PRL, LHB, CYP11A1, HSD3B1, HSD3B2, HSD17B2, CYP17, SRD5A2, AKR1C3, UGT2B15, AR, SHBG, and KLK3 from the androgen pathway and CYP19, HSD17B1, ..
  32. doi Chorangiocarcinoma: a case report and review of the literature
    Ilana Ariel
    Perinatal Pathology Unit, Hadassah Hebrew University Medical Center, Mount Scopus, Jerusalem, Israel
    Int J Gynecol Pathol 28:267-71. 2009
    ..strongly positive for pancytokeratin and the beta subunit of human chorionic gonadotropin and focally positive for HSD3B1. There was no invasion of the basement membrane, and no free-floating tumor cells in the intervillous space...
  33. pmc The mouse follicle microenvironment regulates antrum formation and steroid production: alterations in gene expression profiles
    Erin R West-Farrell
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biol Reprod 80:432-9. 2009
    ..The expression levels of genes (Star, Cyp11a1, Cyp17a1, Hsd3b1, Cyp19a1, Fshr, Lhcgr, Aqp7, Aqp8, Aqp9, and Hif1a) were measured and correlated to follicle developmental status...
  34. ncbi Chromosome localization of the 31 type I Texas bovine markers in sheep and goat chromosomes by comparative FISH-mapping and R-banding
    G P Di Meo
    National Research Council CNR, ISPAAM, Laboratory of Animal Cytogenetics and Gene Mapping, Naples, Italy
    Anim Genet 34:294-6. 2003
    ..In addition, we have extended physical maps of sheep and goat as 11 genes (HSD3B1, INHBA, CSN10, IGF2R, PIGR, MAP1B, DSC1, ELN, TNFRSF6, CGN1, IGF2) and 14 genes (SOD1, HSD3B1, CSN10, IGF2R, RB1, ..
  35. pmc Adrenal androgen production in catarrhine primates and the evolution of adrenarche
    Robin M Bernstein
    Department of Anthropology, Center for the Advanced Study of Hominid Paleobiology, George Washington University, Washington, DC 20052, USA
    Am J Phys Anthropol 147:389-400. 2012
    ..mediated by a retrotransposon that resulted in two 3-β-hydroxysteroid dehydrogenase/Delta 5-Delta 4 genes (HSD3B1 and HSD3B2) with tissue specific functions in catarrhines...
  36. pmc Dioxin exposure reduces the steroidogenic capacity of mouse antral follicles mainly at the level of HSD17B1 without altering atresia
    Bethany N Karman
    Department of Comparative Biosciences, University of Illinois at Urbana Champaign, Urbana, IL 61802, USA
    Toxicol Appl Pharmacol 264:1-12. 2012
    ..TCDD exposure for 48h increased levels of A4, without changing HSD3B1 protein, HSD17B1 protein, estrone (E1), T or E2 levels...
  37. doi Effects of low concentrations of the antiprogestin mifepristone (RU486) in adults and embryos of zebrafish (Danio rerio): 2. Gene expression analysis and in vitro activity
    Nancy Blüthgen
    University of Applied Sciences Northwestern Switzerland, School of Life Sciences, Institute for Ecopreneurship, Gründenstrasse 40, 4132 Muttenz, Switzerland University of Basel, Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland
    Aquat Toxicol 144:96-104. 2013
    ..enzymes including 17β-hydroxysteroid dehydrogenase type 3 (hsd17b3), 3 β-hydroxysteroid dehydrogenase (hsd3b), P450 aromatase A (cyp19a) and 11β-hydroxylase (cyp11b)...
  38. pmc Proliferation of luteal steroidogenic cells in cattle
    Shin Yoshioka
    Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan
    PLoS ONE 8:e84186. 2013
    ..was expressed during the early, developing and mid luteal stages and some Ki-67-positive cells co-expressed HSD3B (a steroidogenic marker)...
  39. doi Molecular determinants of a competent bovine corpus luteum: first- vs final-wave dominant follicles
    E Gregson
    School of BiosciencesUniversity of Nottingham, Loughborough, UK
    Reproduction 151:563-75. 2016
    ..These impaired CLs had reduced expression of steroidogenic enzymes (e.g. STAR and HSD3B1), luteotrophic receptors (LHCGR) and angiogenic regulators (e.g...
  40. ncbi Effects of butylated hydroxyanisole on the steroidogenesis of rat immature Leydig cells
    Xiaoheng Li
    a Center of Scientific Research, The Second Affiliated Hospital and Yuying Children s Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
    Toxicol Mech Methods 26:511-519. 2016
    ..Q-PCR was used to measure the mRNA levels of following genes: Lhcgr, Scarb1, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, Srd5a1 and Akr1c14...
  41. ncbi Apelin (APLN) and Apelin Receptor (APLNR) in Human Ovary: Expression, Signaling, and Regulation of Steroidogenesis in Primary Human Luteinized Granulosa Cells
    Jennifer Roche
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, Nouzilly, France
    Biol Reprod 95:104. 2016
    ..presence of ML221, an APLNR antagonist, which was associated with an increased 3beta-hydrosteroid dehydrogenase (HSD3B) protein concentration...
  42. doi Progressive effects of silver nanoparticles on hormonal regulation of reproduction in male rats
    K Dziendzikowska
    Division of Nutrition Physiology, Department of Dietetics, Faculty of Human Nutrition and Consumer Science, Warsaw University of Life Sciences SGGW, Nowoursynowska 159C, 02 776 Warsaw, Poland Electronic address
    Toxicol Appl Pharmacol 313:35-46. 2016
    ..involved in steroidogenesis and the steroids metabolism revealed significant down-regulation of Star, Cyp11a1, Hsd3b1, Hsd17b3 and Srd5a1 mRNAs in AgNPs/AgSPs-exposed animals...
  43. ncbi Congenital adrenal hyperplasia due to 3beta-hydroxysteroid dehydrogenase/Delta(5)-Delta(4) isomerase deficiency
    Jacques Simard
    Cancer Genomics Laboratory, Oncology and Molecular Endocrinology Research Center, Laval University Medical Center CHUL, Laval University, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2
    Semin Reprod Med 20:255-76. 2002
    ..Indeed these experiments confirm that no functional 3betaHSD type II isoenzyme is expressed in the adrenals and gonads of the patients suffering from a severe salt-wasting ..
  44. doi The mycotoxins alternariol and alternariol methyl ether negatively affect progesterone synthesis in porcine granulosa cells in vitro
    U Tiemann
    Research Institute for the Biology of Farm Animals, Dummerstorf, Germany
    Toxicol Lett 186:139-45. 2009
    ..enzyme (P450SCC) and 3-beta-hydroxysteroid dehydrogenase (3-beta-HSD), and of the corresponding Cyp11a1 and Hsd3b transcripts in cultured pig granulosa cells. Already 0.8 microM, AOH and AME inhibited P(4) secretion and 1...
  45. pmc Influences of sex, incubation temperature, and environmental quality on gonadal estrogen and androgen receptor messenger RNA expression in juvenile American alligators (Alligator mississippiensis)
    Brandon C Moore
    Department of Biology, University of Florida, Gainesville, Florida, USA
    Biol Reprod 82:194-201. 2010
    ..Elevated ESR2 and CYP19A1 expressions were diagnostic of alligator ovary, whereas elevated HSD3B1, CYP11A1, and CYP17A1 expressions were indicative of testis...
  46. pmc Transcript profiling of candidate genes in testis of pigs exhibiting large differences in androstenone levels
    Eli Grindflek
    Norsvin, The Norwegian Pig Breeders Association, Hamar, Norway
    BMC Genet 11:4. 2010
    ..The primary goal of the present investigation was to determine the differential gene expression of selected candidate genes related to levels of androstenone in pigs...
  47. doi The pre-ovulatory luteinizing hormone surge is followed by down-regulation of CYP19A1, HSD3B1, and CYP17A1 and chromatin condensation of the corresponding promoters in bovine follicles
    Marika Nimz
    Leibniz Institute for Farm Animal Biology FBN, Dummerstorf, Germany
    Mol Reprod Dev 77:1040-8. 2010
    ..CYP19A1, HSD3B1, and CYP17A1 transcripts, which encode key enzymes of steroid hormone biosynthesis, were quantified by real-time ..
  48. doi Expression of 3β-HSD1 and P450 Aromatase enzymes during mouse gonad differentiation
    N R Antonio-Rubio
    Department of Cell Biology and Physiology, Instituto de Investigaciones Biomedicas, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, Mexico, DF, Mexico
    J Mol Histol 42:535-43. 2011
    ....
  49. doi Adverse effects of di-(2-ethylhexyl) phthalate on Leydig cell regeneration in the adult rat testis
    Xing Wang Li
    Institute of Reproductive Biomedicine and the 2nd Affiliated Hospital, Wenzhou Medical College, Wenzhou, Zhejiang 325027, PR China
    Toxicol Lett 215:84-91. 2012
    ..Quantitative PCR showed that Leydig cell specific genes including Lhcgr, Cyp11a1, Hsd3b1, and Insl3 were significantly down-regulated in 750 mg/kg DEHP-treated testes on post-EDS day 21 and beyond...
  50. doi Neurosteroidogenic enzymes and their regulation in the early brain of the protogynous grouper Epinephelus coioides during gonadal sex differentiation
    Ganesan Nagarajan
    Department of Aquaculture, National Taiwan Ocean University, Keelung 20224, Taiwan
    Gen Comp Endocrinol 181:271-87. 2013
    ..The temporal expressions of key enzymes, cyp11a1 (cytochrome P450 side chain cleavage), hsd3b1 (3β-hydroxysteroid dehydrogenase) and cyp17a1 (cytochrome P450c17) were studied at different developmental ages (..
  51. doi 171 expression of androgen-producing enzymes in nelore and angus heifers with low and high numbers of follicles in the ovary
    B Loureiro
    Universidade Estadual Paulista, Botucatu, Sao Paulo, Brazil
    Reprod Fertil Dev 25:234. 2012
    ..This experiment was designed to assess mRNA levels of androgen-producing enzymes (CYP11A1, CYP17A1, HSD3B, HSD17B) in Nelore and Angus heifers with high (HFC) and low follicle counts (LFC)...
  52. doi Effects of hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 polymorphisms on fat androstenone level and gene expression in Duroc pigs
    J M Kim
    College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea
    Anim Genet 44:592-5. 2013
    ..Porcine hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (3β-HSD, also known as HSD3B1) plays a key role in the hepatic metabolism that catalyzes androstenone to β-androstenol...
  53. doi Misregulated progesterone secretion and impaired pregnancy in Cyp11a1 transgenic mice
    Yu Chien
    Institute of Biochemistry and Molecular Biology, National Yang Ming University, Taipei, Taiwan
    Biol Reprod 89:91. 2013
    ..P4), which is secreted from ovarian luteal cells via enzymatic steps catalyzed by P450scc (CYP11A1) and HSD3B. The development and maintenance of corpora lutea during pregnancy, however, are less well understood...
  54. pmc A gain-of-function mutation in DHT synthesis in castration-resistant prostate cancer
    Kai Hsiung Chang
    Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
    Cell 154:1074-84. 2013
    ..We suggest that 3βHSD1 is a valid target for the treatment of CRPC. ..
  55. doi Endometrial Intracrinology--generation of an estrogen-dominated microenvironment in the secretory phase of women
    D A Gibson
    Medical Research Council MRC Centre for Reproductive Health, The University of Edinburgh, Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK
    J Clin Endocrinol Metab 98:E1802-6. 2013
    ..The human endometrium is a complex multicellular tissue subject to cyclical fluctuations in ovarian-derived steroid hormones. Fertile cycles are characterized by differentiation (decidualization) of endometrial stromal cells (ESC)...
  56. doi Hepatic transcriptome profiling identifies differences in expression of genes associated with changes in metabolism and postnatal growth between Hereford and Holstein-Friesian bulls
    Pawel Lisowski
    Department of Molecular Biology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Postepu 36A, 05 552, Magdalenka, Jastrzebiec n Warsaw, Poland
    Anim Genet 45:288-92. 2014
    ..H bulls, we observed up-regulation of genes involved in fatty acid biosynthesis and lipid metabolism (CD36, CAT, HSD3B1, FABP1, ACAA1) and involved in insulin signaling (INSR, INSIG2, NR4A1) and down-regulation of genes involved in ..
  57. pmc Peripheral benzodiazepine receptor/translocator protein global knock-out mice are viable with no effects on steroid hormone biosynthesis
    Lan N Tu
    From the Department of Animal Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, New York 14853 and
    J Biol Chem 289:27444-54. 2014
    ..of gene expression profiles showed that genes involved in steroid hormone biosynthesis (Star, Cyp11a1, and Hsd3b1) were unchanged in Tspo(-/-) mice...
  58. doi Molecular adaptations of testosterone-producing Leydig cells during systemic in vivo blockade of the androgen receptor
    Maja M Bjelic
    Reproductive Endocrinology and Signaling Group, Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia
    Mol Cell Endocrinol 396:10-25. 2014
    ..Testosterone-reduced expression of some steroidogenic enzymes/proteins (Tspo,StAR,Hsd3b1/2) and transcription factors (Nur77,Gata4,Dax1) was completely abrogated, while decreased expression of Star,..
  59. pmc Time-course changes of steroidogenic gene expression and steroidogenesis of rat Leydig cells after acute immobilization stress
    Han Lin
    Department of Anesthesiology of the Second Affiliated Hospital
    Int J Mol Sci 15:21028-44. 2014
    ..Other mRNA levels, including Cyp11a1, Hsd3b1 and Hsd17b3, began to decline after 3 h. Hsd11b1 and Nos2 mRNA levels did not change during the course of stress...
  60. doi Using SILAC proteomics to investigate the effect of the mycotoxin, alternariol, in the human H295R steroidogenesis model
    Shewit Kalayou
    Norwegian School of Veterinary Science, Oslo, Norway
    Cell Biol Toxicol 30:361-76. 2014
    ..in early stages of steroid biosynthesis (SOAT1, NPC1, and ACBD5) and C21-steroid hormone metabolism (CYP21A2 and HSD3B1)...
  61. pmc Variant allele of HSD3B1 increases progression to castration-resistant prostate cancer
    Gang Wu
    Department of Urology, Tongji Hospital, Tongji University School of Medicine, Shanghai, PR China
    Prostate 75:777-82. 2015
    ....
  62. doi Regulated C-C motif ligand 2 (CCL2) in luteal cells contributes to macrophage infiltration into the human corpus luteum during luteolysis
    Junko Nio-Kobayashi
    MRC Centre for Reproductive Health, The Queen s Medical Research Institute, The University of Edinburgh, Edinburgh EH16 4TJ, UK Laboratory of Histology and Cytology, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Mol Hum Reprod 21:645-54. 2015
    ..CCL2 mRNA expression was negatively correlated with both HSD3B1 and PGES, suggesting that locally produced progesterone and PGE suppress macrophage infiltration into the CL...
  63. doi Melatonin replacement restores the circadian behavior in adult rat Leydig cells after pinealectomy
    Aleksandar Z Baburski
    Department of Biology and Ecology, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia
    Mol Cell Endocrinol 413:26-35. 2015
    ..increased 24-h-oscillations of serum testosterone and LC's cAMP levels, expression of Insl3, Per1, Star/StAR, Hsd3b1/2, Nur77, decreased Arr19 and canceled Per2 oscillatory expression pattern...
  64. doi Gestational N-hexane inhalation alters the expression of genes related to ovarian hormone production and DNA methylation states in adult female F1 rat offspring
    Hong Li
    Department of Pharmaceuticals, Fujian Health College, Fuzhou 350101, China
    Toxicol Lett 239:141-51. 2015
    ..the 500 ppm group, and decreased and significantly upregulated mRNA expression of the Star, Cyp11a1, Cyp17a1, and Hsd3b genes was observed in the 12,500 ppm and 500 ppm groups, respectively...
  65. doi Morphological characterization of adult mouse Leydig cells in culture
    Jian qi Wang
    Transgenic and Stem Cell Core, Institute of Animal Sciences and Veterinary Medicine, Chinese Academy of Agricultural Sciences, Beijing 100193, PR China
    Biochem Biophys Res Commun 469:836-41. 2016
    ..The Leydig cells were identified by HSD3B staining and RT-PCR...
  66. pmc Effects of in Utero Exposure to Dicyclohexyl Phthalate on Rat Fetal Leydig Cells
    Xiaoheng Li
    The Second Affiliated Hospital and amp Yuying Children s Hospital of Wenzhou Medical University, Wenzhou 325027, China
    Int J Environ Res Public Health 13:. 2016
    ..DCHP reduced the expression levels of steroidogenesis-related genes (including Star, Hsd3b1, and Hsd17b3) and testis-descent related gene Insl3 as well as protein levels of 3β-hydroxysteroid dehydrogenase ..
  67. pmc Comparison of the Effects of Dibutyl and Monobutyl Phthalates on the Steroidogenesis of Rat Immature Leydig Cells
    Linxi Li
    Center of Scientific Research, The Second Affiliated Hospital and Yuying Children s Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325027, China
    Biomed Res Int 2016:1376526. 2016
    ..MBP mainly downregulated Cyp11a1 and Hsd3b1 expression levels at 50 nM...
  68. doi Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II
    Hitoshi Okamura
    Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Hypertens Res 39:681-687. 2016
    ..of a DNA microarray analysis of the adrenal gland and subsequent biochemical analyses, we discovered that Hsd3b6/HSD3B1, a subtype of 3β-HSD, is markedly overexpressed in aldosterone-producing cells in the Cry-null adrenal cortex...
  69. ncbi Structure and expression of a new complementary DNA encoding the almost exclusive 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in human adrenals and gonads
    E Rheaume
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Center, Quebec, Canada
    Mol Endocrinol 5:1147-57. 1991
    ..The present data show for the first time that adrenals and gonads express a type of 3 beta HSD isoenzyme that is distinct from the type expressed in the placenta.(ABSTRACT TRUNCATED AT 400 WORDS)..
  70. ncbi Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells
    Y Lachance
    Medical Research Council Group in Molecular Endocrinology, CHUL Research Centre, Quebec, Canada
    J Biol Chem 265:20469-75. 1990
    ....
  71. ncbi Genome-wide linkage analysis of systolic and diastolic blood pressure: the Québec Family Study
    T Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 102:1956-63. 2000
    ..While some loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals that can be detected with a genome scan approach...
  72. ncbi The partial female to male sex reversal in Wnt-4-deficient females involves induced expression of testosterone biosynthetic genes and testosterone production, and depends on androgen action
    Minna Heikkilä
    Biocenter Oulu, University of Oulu, Aapistie 5A, University of Oulu, P O Box 5000, FIN 90014 Oulu, Finland
    Endocrinology 146:4016-23. 2005
    ..to the synthesis of testosterone in the mouse is induced in the Wnt-4-deficient ovary, including Cyp11a, Cyp17, Hsd3b1, Hsd17b1, and Hsd17b3...
  73. ncbi Assignment of the bovine PTGFR and HSD3B1 genes to bovine chromosome 3 with somatic and radiation hybrid panel mapping
    L C Nakata
    Department of Biology, IBILCE, UNESP, Sao Paulo State University, Sao Jose Rio Preto, SP, Brazil
    Cytogenet Genome Res 114:94E. 2006
  74. ncbi Effects of metformin on bovine granulosa cells steroidogenesis: possible involvement of adenosine 5' monophosphate-activated protein kinase (AMPK)
    Lucie Tosca
    Unite de Physiologie de la Reproduction et des Comportements, Institut National de la Recherche Agronomique, 37380 Nouzilly, France
    Biol Reprod 76:368-78. 2007
    ..follicles, metformin (10 mM) reduced production of both progesterone and estradiol and decreased the abundance of HSD3B, CYP11A1, and STAR proteins in presence or absence of FSH (10(-8) M) and IGF1 (10(-8) M)...
  75. doi Plasticity of the zona reticularis in the adult marmoset adrenal cortex: voyages of discovery in the New World
    J Christina Pattison
    Perinatal Research Laboratories, University of Wisconsin Madison, 7E Meriter Hospital Park, 202 South Park Street, Madison, Wisconsin 53715, USA
    J Endocrinol 203:313-26. 2009
    ..by P450c17 (CYP17A1 as listed in HUGO Database) in the ZR results from a coincident fall in the expression of HSD3B, which would otherwise compete for pregnenolone substrate...
  76. doi Transcriptional regulation of steroidogenic genes: STARD1, CYP11A1 and HSD3B
    Holly A Lavoie
    Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC 29208, USA
    Exp Biol Med (Maywood) 234:880-907. 2009
    ..cleavage enzyme, cytochrome P450scc (CYP11A1) and 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase (HSD3B), is tightly controlled by a battery of transcription factors in the adrenal cortex, the gonads and the placenta...
  77. doi IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells
    Arul Murugan Mani
    Reproduction Group, Department of Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire AL9 7TA, UK
    Reproduction 139:139-51. 2010
    ..a significant increase in 17beta-oestradiol (OE(2)) production, cell number and in mRNA expression of CYP11A1, HSD3B1, CYP19A1, BAX, type 1 IGF receptor (IGF1R) and FSHR, while FSH alone had no significant effects...
  78. doi Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6
    Masao Doi
    Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto, Japan
    Nat Med 16:67-74. 2010
    ..Translation of these findings to humans will require clinical examination of human HSD3B1 gene, which we found to be functionally similar to mouse Hsd3b6.
  79. doi Pig preovulatory oocytes modulate cumulus cell protein and gene expression in vitro
    Francois Paradis
    Swine Reproduction Development Program, Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB, Canada
    Mol Cell Endocrinol 320:87-96. 2010
    ..The oocyte also up-regulated HSD3B mRNA, suggesting an effect on cumulus cell progesterone synthesis...
  80. doi Polymorphisms in catechol-O-methyltransferase and cytochrome p450 subfamily 19 genes predispose towards Madurella mycetomatis-induced mycetoma susceptibility
    Wendy W J van de Sande
    Erasmus MC, University Medical Centre Rotterdam, Department of Medical Microbiology and Infectious Diseases, Rotterdam, The Netherlands
    Med Mycol 48:959-68. 2010
    ..cytochrome p450 subfamily 17 (CYP17), cytochrome p450 subfamily 19 (CYP19) and hydroxysteroid dehydrogenase 3B (HSD3B). Significant differences in allele distribution were demonstrated for CYP19 (P=0.004) and COMT (P=0...
  81. ncbi A case of primary aldosteronism caused by multiple adrenocortical macronodules
    Naoko Hashimoto
    Division of Diabetes and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Intern Med 50:585-90. 2011
    ..immunohistochemical analysis demonstrated that these nodules were positive for 3β-hydroxysteroid dehydrogenase (HSD3B) but not for CYP17...
  82. pmc Genomic biomarkers of phthalate-induced male reproductive developmental toxicity: a targeted RT-PCR array approach for defining relative potency
    Bethany R Hannas
    Reproductive Toxicology Branch, Toxicology Assessment Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 125:544-57. 2012
    ..the six phthalates from most to least was Cyp11b1 > Star = Scarb1 > Cyp17a1 = T production > Cyp11a1 = Hsd3b = Insl3 > Cyp11b2...
  83. ncbi Towards an understanding of the evolution of the chorioallantoic placenta: steroid biosynthesis and steroid hormone signaling in the chorioallantoic membrane of an oviparous reptile
    Lori Cruze
    Department of Biology, University of Florida, Gainesville, Florida, USA
    Biol Reprod 87:71. 2012
    ..the regulation of steroidogenesis (NR5A1), the key steroidogenic enzymes involved in the synthesis of progestins (HSD3B1), androgens (CYP17A1), and estrogens (CYP19A1), and the receptors involved in the signaling of progestins (PR), ..
  84. pmc Genetic susceptibility factors on genes involved in the steroid hormone biosynthesis pathway and progesterone receptor for gastric cancer risk
    Lisa Y Cho
    Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea
    PLoS ONE 7:e47603. 2012
    The objective of the study was to investigate the role of genes (HSD3B1, CYP17A1, CYP19A1, HSD17B2, HSD17B1) involved in the steroid hormone biosynthesis pathway and progesterone receptor (PGR) in the etiology of gastric cancer in a ..
  85. doi 235 progesterone affects the messenger RNA expression of in vitro-produced bovine embryos
    K Knauer
    University of Veterinary Medicine, Foundation, Hannover, Germany
    Reprod Fertil Dev 25:265. 2012
    ..Subsequently, the relative amounts of six developmentally important gene transcripts (IGF1R, SLC2A1, HSD3B1, IFNT, PGRMC1, and PGRMC2) were analysed in single embryos of all groups...
  86. doi 267 effect of follicular fluid concentration on in vitro development of porcine oocytes and the expression of genes related to cumulus expansion and embryo quality
    J E Park
    Seoul National University, Seoul, Korea
    Reprod Fertil Dev 25:281. 2012
    ..6±3.1 v. 54.4±2.5, respectively). In addition, the expression of matrix molecule (HAS2, GREM1), steroidogenesis (HSD3B), epidermal growth factor signalling (AREG, BTC), and cell cycle regulator (CCND2) genes were upregulated in the ..
  87. doi Reversible infertility in a liver receptor homologue-1 (LRH-1)-knockdown mouse model
    Han Gerrits
    Merck Sharp and Dohme Research Laboratories, Women s Health Department, Molenstraat 110, 5342 CC, Oss, The Netherlands Corresponding author Email
    Reprod Fertil Dev 26:293-306. 2014
    ..with the observed decrease in plasma progesterone levels, key steroid biosynthesis genes, namely Star, Cyp11a1, Hsd3b and Scarb1, were downregulated in LRH-1-knockdown ovaries...
  88. doi Sertoli cell androgen receptor expression regulates temporal fetal and adult Leydig cell differentiation, function, and population size
    Rasmani Hazra
    ANZAC Research Institute, Concord Hospital, Sydney, New South Wales 2139, Australia
    Endocrinology 154:3410-22. 2013
    ..gene expression, with down-regulated Star, Cyp11a1, and Cyp17a1 expression contrasting with up-regulated Hsd3b1, Hsd17b3, and Srd5a1 expression...
  89. doi Androgen metabolite-dependent growth of hormone receptor-positive breast cancer as a possible aromatase inhibitor-resistance mechanism
    Toru Hanamura
    Department of Molecular and Functional Dynamics, Graduate School of Medicine, Tohoku University, 2 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Breast Cancer Res Treat 139:731-40. 2013
    ..5α-Androstane-3β,17β-diol (3β-diol) generated from DHT by 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) shows androgenic and substantial estrogenic activities, representing a potential mechanism of AI resistance...
  90. doi Short oestrous cycles in sheep during anoestrus involve defects in progesterone biosynthesis and luteal neovascularisation
    H M Brown
    UMR Physiologie de la Reproduction et des Comportements, UMR 6175, INRA CNRS Université de Tours Haras Nationaux, 37380 Nouzilly, France
    Reproduction 147:357-67. 2014
    ..loss of expression of genes coding key proteins involved in the biosynthesis of progesterone (STAR, CYP11A1 and HSD3B1 (HSD3B)) as well as genes coding proteins critical for vascular development during early luteal development (VEGFA ..
  91. doi Isoform-specific monoclonal antibodies against 3β-hydroxysteroid dehydrogenase/isomerase family provide markers for subclassification of human primary aldosteronism
    Masao Doi
    Department of Systems Biology M D, J M F, M T, Y H, Y T, H O, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan and Departments of Medicine F S, R M, S I, Pathology T M, Y N, H S, and Radiology K T, Division of Nephrology, Endocrinology, and Vascular Medicine, Tohoku University Hospital, Sendai 980 8574, Japan
    J Clin Endocrinol Metab 99:E257-62. 2014
    ..Two different isoforms of 3β-hydroxysteroid dehydrogenase (HSD3B1 and HSD3B2) are thought to be expressed in the human adrenal gland, but the lack of isoform-specific antibody has ..
  92. pmc Androgen deficiency during mid- and late pregnancy alters progesterone production and metabolism in the porcine corpus luteum
    Malgorzata Grzesiak
    1Department of Endocrinology, Institute of Zoology, Jagiellonian University in Krakow, Krakow, Poland
    Reprod Sci 21:778-90. 2014
    ..The 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (HSD3B) mRNA and protein expression were significantly reduced only in the GD108F group as compared with the control...
  93. doi Alginate hydrogel matrix stiffness influences the in vitro development of caprine preantral follicles
    I R Brito
    Faculty of Veterinary, Laboratory of Manipulation of Oocyte and Preantral Follicles LAMOFOPA, PPGCV, State University of Ceara, Fortaleza, CE, Brazil
    Mol Reprod Dev 81:636-45. 2014
    ..5, ALG 1, or the control, as well as higher levels of CYP19A1 and HSD3B mRNA. In conclusion, a three-dimensional system that uses ALG 0...
  94. doi Mitochondrial complex I gene variations; as a potential genetic risk factor in pathogenesis of multiple sclerosis
    Ahmad Poursadegh Zonouzi
    Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
    J Neurol Sci 345:220-3. 2014
    ..In this study, we investigated the possible association between mitochondrial complex I gene variations and MS in a Filipino population...
  95. pmc Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects
    Sarah J Nyante
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    Cancer Causes Control 26:121-31. 2015
    ..19 subfamily A polypeptide 1 (CYP19A1), estrogen receptor (ESR1), 3-beta hydroxysteroid dehydrogenase type I (HSD3B1), 17-beta hydroxysteroid dehydrogenase type II (HSD17B2), progesterone receptor (PGR), and sex hormone-binding ..
  96. doi GATA4 knockdown in MA-10 Leydig cells identifies multiple target genes in the steroidogenic pathway
    Francis Bergeron
    ReproductionMother and Child Health, Room T3 67, Centre de Recherche du Centre Hospitalier Universitaire CHU de Québec, Centre de Recherche en Biologie de la Reproduction CRBR, 2705 Laurier Boulevard, Quebec City, Quebec, Canada G1V 4G2Department of Obstetrics and GynecologyFaculty of Medicine, Laval University, Quebec City, Quebec, Canada G1K 7P4
    Reproduction 149:245-57. 2015
    ..Gata4 knockdown also led to an important decrease in other novel steroidogenic targets including Srd5a1, Gsta3, Hsd3b1, and Hsd3b6, as well as genes known to participate in cholesterol metabolism such as Scarb1, Ldlr, Soat1, Scap, ..
  97. doi Effects of bleomycin, etoposide and cisplatin treatment on Leydig cell structure and transcription of steroidogenic enzymes in rat testis
    Maie Al-Bader
    Departments of Physiology, Faculty of Medicine, Kuwait University, Kuwait
    Eur J Pharmacol 747:150-9. 2015
    ..inhibitory effects on the transcription of all of the above genes in addition to luteinizing hormone receptor and HSD3B1, but not on the StAR gene...
  98. doi Prolonged in vivo administration of testosterone-enanthate, the widely used and abused anabolic androgenic steroid, disturbs prolactin and cAMP signaling in Leydig cells of adult rats
    Maja M Bjelic
    Reproductive Endocrinology and Signaling Group, Faculty of Sciences, University of Novi Sad, Novi Sad, Serbia
    J Steroid Biochem Mol Biol 149:58-69. 2015
    ..Oppositely, Hsd3b1/2, Hsd3b5, Hsd17b4, Ar, Arr19 increased...
  99. pmc Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis
    Sameer S Udhane
    1 Pediatric Endocrinology and Diabetology, Department of Pediatrics, University Children s Hospital, Inselspital 2 The Department of Clinical Research, University of Bern, 3010 Bern, Switzerland
    Sci Rep 5:10132. 2015
    ..profiling of normal versus starved H295R cells revealed fourteen differentially expressed genes; HSD3B2, HSD3B1, CYP21A2, RARB, ASS1, CFI, ASCL1 and ENC1 play a role in steroid and energy metabolism and ANGPTL1, PLK2, DUSP6, ..
  100. doi Comparative analysis of intraluteal steroidogenic enzymes emphasises the functionality of fresh and persistent corpora lutea during pro--and metoestrus in the lynx
    Lina Zschockelt
    Leibniz Institute for Zoo and Wildlife Research, Department of Reproduction Biology, PF700430, 10324 Berlin, Germany Electronic address
    J Steroid Biochem Mol Biol 154:75-84. 2015
    ..It is noteworthy that the HSD3B1 mRNA amount was significantly elevated in fresh compared to perCLs (metoestrus)...
  101. doi Oxytocin differentially effects 3β-hydroxysteroid dehydrogenase and 5α-reductase activities in prostate cancer cell lines
    Stephen J Assinder
    Disciplines of Physiology, School of Medical Sciences and Bosch Institute, University of Sydney, NSW 2006, Australia Electronic address
    Peptides 71:149-55. 2015
    ..oxytocin stimulates steroidogenesis in several organs by modulating activity of 3β-hydroxysteroid dehydrogenases (HSD3B) and steroid 5α-reductases (SRD5A)...

Research Grants13

  1. Ethnic difference in prostate cancer
    Timothy R Rebbeck; Fiscal Year: 2010
    ..CYP19, 5alpha-reductase II (SRD5A2), androgen receptor (AR), and the hydroxy-steroid dehydrogenases type II 3beta (HSD3B) and type 17beta (HSD17B)...
  2. Genes, Hormones and Breast Cancer Risk
    Veronica Wendy Setiawan; Fiscal Year: 2010
    ..plasma hormone levels, 2) characterize genetic variation of estrogen biosynthesis genes (CYP11A, CYP17, CYP19, HSD3B1, HSD3B2, HSD17B1, HSD17B2, and SHBG) using a two-pronged approach (putative functional variants and inferred ..
  3. PLACENTAL 3 BETA-HYDROXYSTEROID DEHYDROGENASE/ISOMERASE
    James Thomas; Fiscal Year: 2003
    ..The absence of detergent in the pure cytosolic enzyme preparation facilitates the growth of crystals for future structural studies. ..
  4. Placental 3B-Hydroxysteroid Dehydrogenase/Isomerase
    James Thomas; Fiscal Year: 2008
    ..These studies may ultimately produce new treatments for the prevention of premature birth and the treatment of hormone-sensitive breast cancer while leaving adrenal steroidogenesis intact. [unreadable] [unreadable]..
  5. Rhesus-Human Adrenal Comparisons During Aging
    Charles Parker; Fiscal Year: 2002
    ..abstract_text> ..
  6. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
    ..Such knowledge can be applied for promoting or inhibiting these critical facets of ovarian physiology, thereby allowing us to better manage fertility, infertility, and ovarian-based disorders. [unreadable] [unreadable]..
  7. ETIOLOGY, HORMONAL CRITERIA OF 3 BETA HSD DEFICIENCY
    Songya Pang; Fiscal Year: 2002
    ....
  8. OVARIAN LDL RECEPTOR AND STAR GENE REGULATION
    HOLLY LAVOIE; Fiscal Year: 2003
    ..These studies will promote our understanding of how multiple genes are coordinated by different trophic factors in the ovary during follicular differentiation and add to our understanding of mechanisms of infertility. ..
  9. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..
  10. ESTROGEN, DIET, GENETICS AND ENDOMETRIAL CANCER
    Sara Olson; Fiscal Year: 2005
    ..This study will provide data on genetic susceptibility in endometrial cancer in conjunction with established risk factors, as well as the first epidemiologic data on the more lethal serous and clear cell tumors. ..
  11. MENOPAUSAL TRANSITION: A BIOBEHAVIORAL MODEL OF SYMPTOMS
    Ellen Mitchell; Fiscal Year: 2006
    ..abstract_text> ..
  12. Vascular and Inflammatory Predictors of MCI Risk and Progression
    ROSEBUD ROBERTS; Fiscal Year: 2008
    ..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]..
  13. Sertoli Cell Mediated Engulfment of Apoptotic Germ Cells
    Kodi S Ravichandran; Fiscal Year: 2010
    ..abstract_text> ..