HSD3B1

Summary

Gene Symbol: HSD3B1
Description: hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Alias: 3BETAHSD, HSD3B, HSDB3, HSDB3A, SDR11E1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1, 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I, 3-beta-HSD I, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-Delta(5)-steroid dehydrogenase, delta-5-3-ketosteroid isomerase, progesterone reductase, short chain dehydrogenase/reductase family 11E, member 1, steroid Delta-isomerase, trophoblast antigen FDO161G
Species: human
Products:     HSD3B1

Top Publications

  1. Thomas J, Duax W, Addlagatta A, Brandt S, Fuller R, Norris W. Structure/function relationships responsible for coenzyme specificity and the isomerase activity of human type 1 3 beta-hydroxysteroid dehydrogenase/isomerase. J Biol Chem. 2003;278:35483-90 pubmed
  2. Lüttgenau J, Lingemann B, Wellnitz O, Hankele A, Schmicke M, Ulbrich S, et al. Repeated intrauterine infusions of lipopolysaccharide alter gene expression and lifespan of the bovine corpus luteum. J Dairy Sci. 2016;99:6639-6653 pubmed publisher
    ..PGE synthase, and the apoptosis-related factor CASP3 were higher, and those of steroidogenic factors STAR and HSD3B, the PGF receptor, and the angiogenic factor VEGFA121 were lower after LPS challenge compared with the control...
  3. Dziendzikowska K, Krawczynska A, Oczkowski M, Królikowski T, Brzoska K, Lankoff A, et al. Progressive effects of silver nanoparticles on hormonal regulation of reproduction in male rats. Toxicol Appl Pharmacol. 2016;313:35-46 pubmed publisher
    ..involved in steroidogenesis and the steroids metabolism revealed significant down-regulation of Star, Cyp11a1, Hsd3b1, Hsd17b3 and Srd5a1 mRNAs in AgNPs/AgSPs-exposed animals...
  4. Peng J, Xin H, Han P, Gao K, Gao T, Lei Y, et al. Expression and regulative function of tissue inhibitor of metalloproteinase 3 in the goat ovary and its role in cultured granulosa cells. Mol Cell Endocrinol. 2015;412:104-15 pubmed publisher
    ..decrease hCG-induced progesterone secretion and the mRNA abundance of key steroidogenic enzymes (StAR, p450scc and HSD3B) as well as ECM proteins (DCN and FN)...
  5. Nio Kobayashi J, Kudo M, Sakuragi N, Kimura S, Iwanaga T, Duncan W. Regulated C-C motif ligand 2 (CCL2) in luteal cells contributes to macrophage infiltration into the human corpus luteum during luteolysis. Mol Hum Reprod. 2015;21:645-54 pubmed publisher
    ..CCL2 mRNA expression was negatively correlated with both HSD3B1 and PGES, suggesting that locally produced progesterone and PGE suppress macrophage infiltration into the CL...
  6. Alamdar A, Xi G, Huang Q, Tian M, Eqani S, Shen H. Arsenic activates the expression of 3?-HSD in mouse Leydig cells through repression of histone H3K9 methylation. Toxicol Appl Pharmacol. 2017;326:7-14 pubmed publisher
    ..further elucidate the mechanism for the activation of 3?-HSD, we determined the histone H3K9 methylation levels in Hsd3b gene promoter, which also showed significant decrease of H3K9me2/3 in the investigated region after arsenic ..
  7. Guo X, Zhou S, Chen Y, Chen X, Liu J, Ge F, et al. Ziram Delays Pubertal Development of Rat Leydig Cells. Toxicol Sci. 2017;160:329-340 pubmed publisher
    ..expression levels of P450 cholesterol side cleavage enzyme (Cyp11a1), 3?-hydroxysteroid dehydrogenase 1 (Hsd3b1), 17?-hydroxylase/17,20-lyase (Cyp17a1), and 17?-hydroxysteroid dehydrogenase 3 (Hsd17b3) via downregulating the ..
  8. Karmaus A, TOOLE C, Filer D, Lewis K, Martin M. High-Throughput Screening of Chemical Effects on Steroidogenesis Using H295R Human Adrenocortical Carcinoma Cells. Toxicol Sci. 2016;150:323-32 pubmed publisher
    ..samples into 5 distinct profiles generally representing putative mechanisms of action, including CYP17A1 and HSD3B inhibition...
  9. Li Y, He X, Yang X, Huang K, Luo Y, Zhu L, et al. Zinc inhibits the reproductive toxicity of Zearalenone in immortalized murine ovarian granular KK-1 cells. Sci Rep. 2015;5:14277 pubmed publisher
    ..promoted the ZEA-induced estrogen production but regulated the expression of steroidogenic enzymes (Star, Cyp11a1, Hsd3b1, Cyp17a1) in different way. All these results indicated that zinc could inhibit the reproductive toxicity of ZEA.

More Information

Publications163 found, 100 shown here

  1. Chen X, Li L, Li H, Guan H, Dong Y, Li X, et al. Prenatal exposure to di-n-butyl phthalate disrupts the development of adult Leydig cells in male rats during puberty. Toxicology. 2017;386:19-27 pubmed publisher
    ..secretion and down-regulation of the mRNA levels of Leydig cell biomarkers including Scarb1, Star, Cyp11a1, Hsd3b1, Hsd11b1, and Hsd17b3 as well as the gonadotroph biomarkers including Lhb and Gnrhr...
  2. Kalayou S, Hamre A, Ndossi D, Connolly L, Sørlie M, Ropstad E, et al. Using SILAC proteomics to investigate the effect of the mycotoxin, alternariol, in the human H295R steroidogenesis model. Cell Biol Toxicol. 2014;30:361-76 pubmed publisher
    ..in early stages of steroid biosynthesis (SOAT1, NPC1, and ACBD5) and C21-steroid hormone metabolism (CYP21A2 and HSD3B1)...
  3. Chen X, Dong Y, Tian E, Xie L, Wang G, Li X, et al. 4-Bromodiphenyl ether delays pubertal Leydig cell development in rats. Chemosphere. 2018;211:986-997 pubmed publisher
    ..in vitro induced ROS generation, inhibited androgen production, down-regulated Lhcgr, Scarb1, Star, Cyp11a1, Hsd3b1, Srd5a1, and Akr1c14 expression in immature Leydig cells after 24-h treatment...
  4. Granum C, Anchersen S, Karlsson C, Berg V, Olsaker I, Verhaegen S, et al. Steroidogenic differential effects in neonatal porcine Leydig cells exposed to persistent organic pollutants derived from cod liver oil. Reprod Toxicol. 2015;57:130-9 pubmed publisher
    ..A decrease in central steriodogenic genes including STAR, CYP11A1, HSD3B and CYP17A1 was obtained in both culture conditions with all POP extracts...
  5. Singh J, Paul A, Thakur N, Yadav V, Panda R, Bhure S, et al. Localization of IGF proteins in various stages of ovarian follicular development and modulatory role of IGF-I on granulosa cell steroid production in water buffalo (Bubalus bubalis). Anim Reprod Sci. 2015;158:31-52 pubmed publisher
    ..Expression of steroidogenic genes (StAR, CYP11A1, HSD3B) and progesterone concentration were increased in a dose and time dependent fashion...
  6. Costa K, da Silva W, Veroneze R, Montes J, Verardo L, Botelho M, et al. Morphological and molecular differences in corpus luteum of pregnant sows from divergent genetic groups. Theriogenology. 2017;104:105-114 pubmed publisher
    ..No differences in protein abundance of steroidogenic enzymes (CYP11A1 and HSD3B1) were observed...
  7. Schörghofer D, Kinslechner K, Preitschopf A, Schütz B, Röhrl C, Hengstschläger M, et al. The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence. Reprod Biol Endocrinol. 2015;13:88 pubmed publisher
    ..02) in patients expressing high intra-tumor levels of SR-BI. SR-BI mRNA correlated with HSD17B1 and HSD3B1 and SR-BI protein staining showed correlation with active ribosomal protein S6 (RS = 0...
  8. Bujnakova Mlynarcikova A, Scsukova S. Simultaneous effects of endocrine disruptor bisphenol A and flavonoid fisetin on progesterone production by granulosa cells. Environ Toxicol Pharmacol. 2018;59:66-73 pubmed publisher
    ..the combinations included a significant down-regulation of the key steroidogenesis-related genes (STAR, CYP11A1, HSD3B)...
  9. Li X, Liu J, Wu S, Zheng W, Li H, Bao S, et al. In utero single low-dose exposure of cadmium induces rat fetal Leydig cell dysfunction. Chemosphere. 2018;194:57-66 pubmed publisher
    ..fetal Leydig cell numbers, downregulated protein expression levels of Leydig (LHCGR, SCARB1, STAR, CYP11A1, HSD3B1, and CYP17A1), and Sertoli cells (HSD17B3, DHH, and FSHR)...
  10. Salvi E, Wang Z, Rizzi F, Gong Y, McDonough C, Padmanabhan S, et al. Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide. Hypertension. 2017;69:51-59 pubmed
    ..the gene-based approach, we identified hydroxy-delta-5-steroid dehydrogenase, 3 ?- and steroid ?-isomerase 1 gene (HSD3B1) as significantly associated with BP response (P<2.28×10-4 )...
  11. Chang B, Zheng S, Hawkins G, Isaacs S, Wiley K, Turner A, et al. Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility. Cancer Res. 2002;62:1784-9 pubmed
    ..for sequence variants in the putative promoter region, exons, exon-intron junctions, and 3'-untranslated region of HSD3B1 and HSD3B2 genes by direct sequencing...
  12. Setlur S, Chen C, Hossain R, Ha J, Van Doren V, Stenzel B, et al. Genetic variation of genes involved in dihydrotestosterone metabolism and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2010;19:229-39 pubmed publisher
    ..We also investigated associations between SNPs in genes (HSD3B1, SRD5A1/2, and AKR1C2) involved in the conversion of testosterone to DHT, and in DHT metabolism and PCA risk...
  13. Zeebaree B, Kwong W, Mann G, Gutierrez C, Sinclair K. Physiological responses of cultured bovine granulosa cells to elevated temperatures under low and high oxygen in the presence of different concentrations of melatonin. Theriogenology. 2018;105:107-114 pubmed publisher
    ..5 °C but to reduce P4 at 40.0 °C. Transcript expression for HSD3B1 paralleled temporal changes in P4 production, and those for HBA were greater at 5% than 20% O2
  14. Zhang T, Guan Y, Wang S, Wang L, Cheng M, Yuan C, et al. Bisphenol A induced abnormal DNA methylation of ovarian steroidogenic genes in rare minnow Gobiocypris rarus. Gen Comp Endocrinol. 2018;: pubmed publisher
    ..elements (ERE) to recruit estrogen receptor (ER), while the 14-day BPA treatment remarkably induced transcript of hsd3b and enhanced the capacity of ERE to recruitment ER in ovaries...
  15. Rosmond R, Chagnon M, Bouchard C, Bjorntorp P. Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type I gene (HSD3B1) and blood pressure. Biochem Biophys Res Commun. 2002;293:629-32 pubmed
    ..the present study was to examine the potential impact of a T-->C substitution at codon Leu(338) of the type I (HSD3B1) 3 beta-HSD gene on obesity, circulating hormones, and estimates of insulin, glucose, and lipid metabolism as well ..
  16. Hearn J, Abuali G, Reichard C, Reddy C, Magi Galluzzi C, Chang K, et al. HSD3B1 and resistance to androgen-deprivation therapy in prostate cancer: a retrospective, multicohort study. Lancet Oncol. 2016;17:1435-1444 pubmed publisher
    b>HSD3B1 (1245A>C) has been mechanistically linked to castration-resistant prostate cancer because it encodes an altered enzyme that augments dihydrotestosterone synthesis from non-gonadal precursors...
  17. Di Luoffo M, Daems C, Bergeron F, Tremblay J. Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells. Biol Reprod. 2015;93:9 pubmed publisher
    ..These include Ahr, Bmal1, Cyp1b1, Hsd3b1, Hsd17b7, Map2k1, Nr0b2, Pde8a, Por, Smad4, Star, and Tsc22d3, which were all downregulated in the absence of MEF2...
  18. Morrison N, Nickson D, McBride M, Mueller U, Boyd E, Sutcliffe R. Regional chromosomal assignment of human 3-beta-hydroxy-5-ene steroid dehydrogenase to 1p13.1 by non-isotopic in situ hybridisation. Hum Genet. 1991;87:223-5 pubmed
  19. Zhang Y, Yuan K, Liang Y, Chu Y, Lian Q, Ge Y, et al. Alterations of gene profiles in Leydig-cell-regenerating adult rat testis after ethane dimethane sulfonate-treatment. Asian J Androl. 2015;17:253-60 pubmed publisher
    ..genes include steroidogenic pathway proteins: steroidogenic acute regulatory protein, Scarb1, Cyp11a1, Cyp17a1, Hsd3b1, Cyp1b1 and Cyp2a1. Seven days after treatment, there were 89 mRNAs up-regulated two-fold or more including Pkib...
  20. Okamura H, Doi M, Goto K, Kojima R. Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II. Hypertens Res. 2016;39:681-687 pubmed publisher
    ..of a DNA microarray analysis of the adrenal gland and subsequent biochemical analyses, we discovered that Hsd3b6/HSD3B1, a subtype of 3?-HSD, is markedly overexpressed in aldosterone-producing cells in the Cry-null adrenal cortex...
  21. Nyante S, Gammon M, Kaufman J, Bensen J, Lin D, Barnholtz Sloan J, et al. Genetic variation in estrogen and progesterone pathway genes and breast cancer risk: an exploration of tumor subtype-specific effects. Cancer Causes Control. 2015;26:121-31 pubmed publisher
    ..19 subfamily A polypeptide 1 (CYP19A1), estrogen receptor (ESR1), 3-beta hydroxysteroid dehydrogenase type I (HSD3B1), 17-beta hydroxysteroid dehydrogenase type II (HSD17B2), progesterone receptor (PGR), and sex hormone-binding ..
  22. Zheng W, Ge F, Wu K, Chen X, Li X, Chen Y, et al. In utero exposure to hexavalent chromium disrupts rat fetal testis development. Toxicol Lett. 2018;299:201-209 pubmed publisher
    ..Further study demonstrated that the expression of Leydig cell (Lhcgr, Scarb1, and Hsd3b1) and Sertoli cell (Fshr, Pdgfa, and Lif) genes in the testis was upregulated at dose of 3 mg/kg while the ..
  23. Bergeron F, Nadeau G, Viger R. GATA4 knockdown in MA-10 Leydig cells identifies multiple target genes in the steroidogenic pathway. Reproduction. 2015;149:245-57 pubmed publisher
    ..Gata4 knockdown also led to an important decrease in other novel steroidogenic targets including Srd5a1, Gsta3, Hsd3b1, and Hsd3b6, as well as genes known to participate in cholesterol metabolism such as Scarb1, Ldlr, Soat1, Scap, ..
  24. Liu Y, Su X, Hao J, Chen M, Liu W, Liao X, et al. Overexpression of PRL7D1 in Leydig Cells Causes Male Reproductive Dysfunction in Mice. Int J Mol Sci. 2016;17: pubmed publisher
    ..regulatory protein (STAR) and hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase cluster (HSD3B). Further studies revealed that PRL7D1 overexpression affected the expression of transferrin (TF) in Sertoli cells...
  25. Samir M, Glister C, Mattar D, Laird M, Knight P. Follicular expression of pro-inflammatory cytokines tumour necrosis factor-α (TNFα), interleukin 6 (IL6) and their receptors in cattle: TNFα, IL6 and macrophages suppress thecal androgen production in vitro. Reproduction. 2017;154:35-49 pubmed publisher
    ..In addition, TNFα reduced INSL3, HSD3B1 and NOS3 expression but increased NOS2 expression...
  26. Legacki E, Ball B, Corbin C, Loux S, Scoggin K, Stanley S, et al. Equine fetal adrenal, gonadal and placental steroidogenesis. Reproduction. 2017;154:445-454 pubmed publisher
    ..i>CYP17A1 was higher in fetal gonads than adrenals or allantochorion, and HSD3B1 was higher in fetal adrenals and allantochorion than gonads...
  27. Tetti M, Castellano I, Venziano F, Magnino C, Veglio F, Mulatero P, et al. Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells. Int J Mol Sci. 2018;19: pubmed publisher
    ..dehydrogenase (Hsd3b6), the murine counterpart to the human type I 3β-hydroxyl-steroid dehydrogenase (HSD3B1) gene...
  28. Guang Yu L, Hai Yan L, Ji Hong L, Yun Cong M, Xue Lian D, Chun Yu L, et al. MCL1 is a key regulator of steroidogenesis in mouse Leydig cells. Mol Reprod Dev. 2016;83:226-35 pubmed publisher
    ..The mRNA abundance of the steroidogenic genes Star, Cyp11a1, Cyp17a1, Hsd3b1, Srd5a, and the luteinizing hormone/choriogonadotropin receptor Lhcgr were significantly reduced following MCL1 ..
  29. Mostaghel E, Zhang A, Hernandez S, Marck B, Zhang X, Tamae D, et al. Contribution of Adrenal Glands to Intra-tumor Androgens and Growth of Castration Resistant Prostate Cancer. Clin Cancer Res. 2018;: pubmed publisher
    ..expressed enzymes for adrenal androgen utilization and 9 expressed enzymes for de novo steroidogenesis (HSD3B1, CYP17A, AKR1C3 and HSD17B3). Mice are appropriate for evaluating adrenal impact of steroidogenesis inhibitors...
  30. Alvarez C, Genti Raimondi S, Patrito L, Flury A. Topography of human placental 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase in microsomal membrane. A study using limited proteolysis and immunoblotting. Biochim Biophys Acta. 1994;1207:102-8 pubmed
  31. Li H, Zhang C, Ni F, Guo S, Wang W, Liu J, et al. Gestational N-hexane inhalation alters the expression of genes related to ovarian hormone production and DNA methylation states in adult female F1 rat offspring. Toxicol Lett. 2015;239:141-51 pubmed publisher
    ..the 500 ppm group, and decreased and significantly upregulated mRNA expression of the Star, Cyp11a1, Cyp17a1, and Hsd3b genes was observed in the 12,500 ppm and 500 ppm groups, respectively...
  32. Nio Kobayashi J, Kudo M, Sakuragi N, Iwanaga T, Duncan W. Loss of luteotropic prostaglandin E plays an important role in the regulation of luteolysis in women. Mol Hum Reprod. 2017;23:271-281 pubmed publisher
    ..05-0.001). PTGES mRNA expression positively correlated with that of 3?-hydroxysteroid dehydrogenase (HSD3B1; r = 0.7836, P < 0.001), while AKR1C3 expression inversely correlated with that of HSD3B1 (r = -0.7514, P = 0...
  33. Hagberg Thulin M, Nilsson M, Thulin P, Céraline J, Ohlsson C, Damber J, et al. Osteoblasts promote castration-resistant prostate cancer by altering intratumoral steroidogenesis. Mol Cell Endocrinol. 2016;422:182-191 pubmed publisher
    ..LNCaP-19 cells displayed an increased expression of genes encoding for steroidogenic enzymes (CYP11A1, HSD3B1, and AKR1C3), estrogen signaling-related genes (CYP19A1, and ESR2), and genes for DHT-inactivating enzymes (UGT2B7,..
  34. Pang S, Wang W, Rich B, David R, Chang Y, Carbunaru G, et al. A novel nonstop mutation in the stop codon and a novel missense mutation in the type II 3beta-hydroxysteroid dehydrogenase (3beta-HSD) gene causing, respectively, nonclassic and classic 3beta-HSD deficiency congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2002;87:2556-63 pubmed
    ..The increased LH in the female with the frameshift genotype and the appropriate LH response in the female with the nonstop genotype correlated with predictably severe and mild ovarian type II 3beta-HSD deficiency, respectively. ..
  35. Beuten J, Gelfond J, Franke J, Weldon K, Crandall A, Johnson Pais T, et al. Single and multigenic analysis of the association between variants in 12 steroid hormone metabolism genes and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2009;18:1869-80 pubmed publisher
    ..risk and the genetic variants of 12 key genes within the steroid hormone pathway (CYP17, HSD17B3, ESR1, SRD5A2, HSD3B1, HSD3B2, CYP19, CYP1A1, CYP1B1, CYP3A4, CYP27B1, and CYP24A1)...
  36. Lin H, Yuan K, Zhou H, Bu T, Su H, Liu S, et al. Time-course changes of steroidogenic gene expression and steroidogenesis of rat Leydig cells after acute immobilization stress. Int J Mol Sci. 2014;15:21028-44 pubmed publisher
    ..Other mRNA levels, including Cyp11a1, Hsd3b1 and Hsd17b3, began to decline after 3 h. Hsd11b1 and Nos2 mRNA levels did not change during the course of stress...
  37. Adam G, Sorensen E, Cravatt B. Trifunctional chemical probes for the consolidated detection and identification of enzyme activities from complex proteomes. Mol Cell Proteomics. 2002;1:828-35 pubmed
  38. Chouhan V, Dangi S, Vazhoor B, Yadav V, Gupta M, Pathak M, et al. Stimulatory effect of luteinizing hormone, insulin-like growth factor-1, and epidermal growth factor on progesterone secretion and viability of cultured bubaline luteal cells. Theriogenology. 2014;82:1212-23 pubmed publisher
    ..STARD1), cytochrome P450 cholesterol side-chain cleavage (CYP11A1), and 3β-hydroxysteroid dehydrogenase (HSD3B), anti-apoptotic gene PCNA, and pro-apoptotic gene BAX in luteal cells of mid-luteal phase in buffalo...
  39. Tao W, Sun L, Shi H, Cheng Y, Jiang D, Fu B, et al. Integrated analysis of miRNA and mRNA expression profiles in tilapia gonads at an early stage of sex differentiation. BMC Genomics. 2016;17:328 pubmed publisher
    ..miR-96, miR-200b, miR-212 and miR-7977) included genes encoding key enzymes in steroidogenic pathways (Cyp11a1, Hsd3b, Cyp19a1a, Hsd11b) and key molecules involved in vertebrate sex differentiation (Foxl2, Amh, Star1, Sf1, Dmrt1, ..
  40. Nakamura I, Kusakabe M, Swanson P, Young G. Regulation of sex steroid production and mRNAs encoding gonadotropin receptors and steroidogenic proteins by gonadotropins, cyclic AMP and insulin-like growth factor-I in ovarian follicles of rainbow trout (Oncorhynchus mykiss) at two stages of vitel. Comp Biochem Physiol A Mol Integr Physiol. 2016;201:132-140 pubmed publisher
    ..steroidogenic acute regulatory protein (star; MV), 3β-hydroxysteroid dehydrogenase/Δ(5-4) isomerase (hsd3b; MV) and P450 aromatase (cyp19a1a; MV) transcript levels...
  41. Mao T, Kurman R, Jeng Y, Huang W, Shih I. HSD3B1 as a novel trophoblast-associated marker that assists in the differential diagnosis of trophoblastic tumors and tumorlike lesions. Am J Surg Pathol. 2008;32:236-42 pubmed publisher
    ..In this report, we assessed the potential of hydroxyl-delta-5-steroid dehydrogenase (HSD3B1), an enzyme that catalyzes the oxidative conversion of delta-5-3 beta-hydroxy steroids to the delta-4-3-keto ..
  42. Zschockelt L, Amelkina O, Koster S, Painer J, Okuyama M, Serra R, et al. Comparative analysis of intraluteal steroidogenic enzymes emphasises the functionality of fresh and persistent corpora lutea during pro--and metoestrus in the lynx. J Steroid Biochem Mol Biol. 2015;154:75-84 pubmed publisher
    ..It is noteworthy that the HSD3B1 mRNA amount was significantly elevated in fresh compared to perCLs (metoestrus)...
  43. Lai T, Li H, Li Y, Hung P, Shyu M, Hu M. Proximal GATA-binding sites are essential for human HSD3B1 gene transcription in the placenta. Sci Rep. 2017;7:4271 pubmed publisher
    ..Two human 3?-HSD isoforms are expressed in a tissue-specific pattern. HSD3B1 (type I) expression is essential to produce progesterone for pregnancy maintenance...
  44. Penny G, Cochran R, Pihlajoki M, Kyrönlahti A, Schrade A, Häkkinen M, et al. Probing GATA factor function in mouse Leydig cells via testicular injection of adenoviral vectors. Reproduction. 2017;154:455-467 pubmed publisher
    ..Three days after Ad-Cre-IRES-GFP injection, expression of androgen biosynthetic genes (Hsd3b1, Cyp17a1 and Hsd17b3) was reduced, whereas expression of another Leydig cell marker, Insl3..
  45. Gupta A, Singh J, Dufort I, Robert C, Dias F, Anzar M. Transcriptomic difference in bovine blastocysts following vitrification and slow freezing at morula stage. PLoS ONE. 2017;12:e0187268 pubmed publisher
    ..mainly involving embryo implantation (PTGS2, CALB1), lipid peroxidation and reactive oxygen species generation (HSD3B1, AKR1B1, APOA1) and cell differentiation (KRT19, CLDN23)...
  46. Jones S, Boisvert A, Francois S, Zhang L, Culty M. In utero exposure to di-(2-ethylhexyl) phthalate induces testicular effects in neonatal rats that are antagonized by genistein cotreatment. Biol Reprod. 2015;93:92 pubmed publisher
    ..DEHP stimulated the mRNA and protein expression of the steroidogenic enzyme HSD3B, uniquely at PND3...
  47. Thitiphuree T, Nagasawa K, Osada M. Molecular identification of steroidogenesis-related genes in scallops and their potential roles in gametogenesis. J Steroid Biochem Mol Biol. 2018;: pubmed publisher
    ..17,20-lyase (cyp17a), 17?-hydroxysteroid dehydrogenase (hsd17b), and 3?-hydroxysteroid dehydrogenase (hsd3b)...
  48. Chang Y, Chen C, Chen M, Lin J, Lin C, Huang W, et al. Expression of 3?-Hydroxysteroid Dehydrogenase Type 1 in Breast Cancer is Associated with Poor Prognosis Independent of Estrogen Receptor Status. Ann Surg Oncol. 2017;24:4033-4041 pubmed publisher
    Human 3?-hydroxysteroid dehydrogenase type 1 (HSD3B1) plays a vital role in steroidogenesis in breast tumors and may therefore be a suitable target for treatment of breast cancer...
  49. Shimodaira M, Nakayama T, Sato N, Aoi N, Sato M, Izumi Y, et al. Association of HSD3B1 and HSD3B2 gene polymorphisms with essential hypertension, aldosterone level, and left ventricular structure. Eur J Endocrinol. 2010;163:671-80 pubmed publisher
    b>HSD3B1 and HSD3B2 are crucial enzymes for the synthesis of hormonal steroids, including aldosterone. Therefore, HSD3B gene variations could possibly influence blood pressure (BP) by affecting the aldosterone level...
  50. Carbunaru G, Prasad P, Scoccia B, Shea P, Hopwood N, Ziai F, et al. The hormonal phenotype of Nonclassic 3 beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females is associated with insulin-resistant polycystic ovary syndrome and is not a variant of inherited HSD3B2 deficiency. J Clin Endocrinol Metab. 2004;89:783-94 pubmed
    To test our hypothesis that the hormonal phenotype of mild 3beta-hydroxysteroid dehydrogenase (HSD3B) deficiency in hyperandrogenic females (HF) is related to insulin-resistant polycystic ovary syndrome (PCOS), we compared insulin ..
  51. Yenuganti V, Viergutz T, Vanselow J. Oleic acid induces specific alterations in the morphology, gene expression and steroid hormone production of cultured bovine granulosa cells. Gen Comp Endocrinol. 2016;232:134-44 pubmed publisher
    ..the transcript abundance of the gonadotropin hormone receptors, FSHR and LHCGR, steroidogenic genes STAR, CYP11A1, HSD3B1 and CYP19A1, the cell cycle regulator CCND2, but not of the proliferation marker PCNA...
  52. Wen Q, Wang Y, Tang J, Cheng C, Liu Y. Sertoli Cell Wt1 Regulates Peritubular Myoid Cell and Fetal Leydig Cell Differentiation during Fetal Testis Development. PLoS ONE. 2016;11:e0167920 pubmed publisher
    ..progenitor cell marker gene Vcam1 were down-regulated, whereas FLC marker genes StAR, Cyp11a1, Cyp17a1 and Hsd3b1 were up-regulated, in neonatal Wt1SC-cKO testes...
  53. Hahn A, Gill D, Nussenzveig R, Poole A, Farnham J, Cannon Albright L, et al. Germline Variant in HSD3B1 (1245 A > C) and Response to Abiraterone Acetate Plus Prednisone in Men With New-Onset Metastatic Castration-Resistant Prostate Cancer. Clin Genitourin Cancer. 2018;16:288-292 pubmed publisher
    The HSD3B1 gene encodes the enzyme 3β-hydroxysteroid dehydrogenase-1 (3βHSD1), which catalyzes adrenal androgen precursors into dihydrotestosterone, the most potent androgen...
  54. La Perle K, Green M, Niewiesk S. Trophoblast deportation to the lungs of cotton rats (Sigmodon hispidus). Comp Med. 2014;64:448-55 pubmed
    ..histologic evidence, limited to the lungs, of embolized cells that were confirmed to be trophoblastic in origin by HSD3B1 immunoreactivity...
  55. Zhu Y, Li E, Sun W, Xu D, Liu Z, Zhao W, et al. Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring. Reprod Toxicol. 2016;61:169-76 pubmed publisher
    ..of serum testosterone, as well as reduced expression of genes related to the androgen signaling pathway (Cyp11a1, Hsd3b, Scarb1, Star, AR, Srd5a2) were found in the testes of ARMs & hypospadias male rats after DBP exposure as ..
  56. Cao F, Zhu L, Li H, Yu S, Wang C, Qiu L. Reproductive toxicity of azoxystrobin to adult zebrafish (Danio rerio). Environ Pollut. 2016;219:1109-1121 pubmed publisher
    ..lhr), steroid hormone receptors (era, er2b and ar), steroidogenic enzymes (cyp11a, cyp11b, cyp17, cyp19a, cyp19b, hsd3b and hsd17b) in the hypothalamic-pituitary-gonad (HPG) axis and vitellogenin (vtg1 and vtg2) in the livers were ..
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    ..expression, and decreased progesterone (P4) production and hydroxyl-delta-5-steroid dehydrogenase 3 beta (HSD3B) mRNA expression (P?<?0.05)...
  58. Buñay J, Larriba E, Patiño Garcia D, Cruz Fernandes L, Castañeda Zegarra S, Rodriguez Fernandez M, et al. Differential Effects of Exposure to Single versus a Mixture of Endocrine-Disrupting Chemicals on Steroidogenesis Pathway in Mouse Testes. Toxicol Sci. 2017;: pubmed publisher
    ..mRNA levels of genes encoding hormones of the steroid pathway (Cyp11a1, Hsd3b1, Cyp17a1 and Cyp19a1), cholesterol transporters (Star), and transcriptional factors (Sp1) showed that mice exposed ..
  59. Taheri S, Zararsiz G, Karaburgu S, Borlu M, Ozgun M, Karaca Z, et al. Is idiopathic hirsutism (IH) really idiopathic? mRNA expressions of skin steroidogenic enzymes in women with IH. Eur J Endocrinol. 2015;173:447-54 pubmed publisher
    ..of genes associated with local androgen synthesis and metabolism (CYP11A1, STS, CYP19A1, SRD5A1, SRD5A2, HSD3B1, AR, COMT, ESR1, ESR2, HSD3B2, CYP17A1, SULT2A1, SULT1E1, HSD17B2, IL6, TGFB1, TNFA) from skin biopsy and blood ..
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    ..Quantitative real-time PCR was applied to assess mRNA expression of steroidogenic factors (STAR, HSD3B), caspase 3, toll-like receptors (TLR2, -4), tumor necrosis factor α (TNFA), and prostaglandin-related factors (..
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    ..Real-time PCR analysis showed that activin A primarily increased Pcna expression but reduced Star, Hsd3b1, and Cyp17a1 expression levels...
  62. Falvo S, Chieffi Baccaria G, Spaziano G, Rosati L, Venditti M, Di Fiore M, et al. StAR protein and steroidogenic enzyme expressions in the rat Harderian gland. C R Biol. 2018;341:160-166 pubmed publisher
    ..The results demonstrate, for the first time, the expression of StAR gene and protein, and Cyp11a1, Hsd3b1, Hsd17b3, Srd5a1, Srd5a2 and Cyp19a1 genes in the rat HG...
  63. Patel R, Fleming J, Mui E, Loveridge C, Repiščák P, Blomme A, et al. Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1. EMBO Mol Med. 2018;10: pubmed publisher
    ..form of CRPC Mechanistically, HER2-IL6 signalling axis enhances the expression of androgen biosynthetic enzyme HSD3B1 and increases SRB1-mediated cholesterol uptake in SPRY2-deficient tumours...
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    ..stimulates steroidogenesis in several organs by modulating activity of 3β-hydroxysteroid dehydrogenases (HSD3B) and steroid 5α-reductases (SRD5A)...
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    ..However, the mechanism is unclear. Progesterone formed by 3?-hydroxysteroid dehydrogenase 1 (HSD3B1) and estradiol by aromatase (CYP19A1) in placenta are critical for maintaining pregnancy...
  66. Chen L, Zhao Y, Li L, Xie L, Chen X, Liu J, et al. Bisphenol A stimulates differentiation of rat stem Leydig cells in vivo and in vitro. Mol Cell Endocrinol. 2018;474:158-167 pubmed publisher
    ..regeneration process by increasing serum testosterone level and Leydig cell-specific gene (Lhcgr, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, and Hsd11b1) and their protein expression levels...
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    ..Among the expression of endocrine-related genes, esr1, ar, cyp19a1b, hsd3b1 and ugt1a1 were all increased by tamoxifen exposure, similar to bisphenol A...
  69. Smolinska N, Dobrzyn K, Kiezun M, Szeszko K, Maleszka A, Kaminski T. Effect of adiponectin on the steroidogenic acute regulatory protein, P450 side chain cleavage enzyme and 3?-hydroxysteroid dehydrogenase gene expression, progesterone and androstenedione production by the porcine uterus during early pregnancy. J Physiol Pharmacol. 2016;67:443-56 pubmed
    ..The expression of steroidogenic acute regulatory protein (StAR) and 3?-hydroxysteroid dehydrogenase (HSD3B1) were observed in the human and porcine uterus during the oestrous cycle and pregnancy...
  70. Roche J, Rame C, Reverchon M, Mellouk N, Cornuau M, Guerif F, et al. Apelin (APLN) and Apelin Receptor (APLNR) in Human Ovary: Expression, Signaling, and Regulation of Steroidogenesis in Primary Human Luteinized Granulosa Cells. Biol Reprod. 2016;95:104 pubmed
    ..presence of ML221, an APLNR antagonist, which was associated with an increased 3beta-hydrosteroid dehydrogenase (HSD3B) protein concentration...
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    ..There was low-level expression of HSD3B and CYP11B2, with HSD3B located mainly in the definitive zone...
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    ..These genes consisted of CYP4A11 (T8590C), RGS2 (1891-1892del TC and G638A), HTR2A (T102C), GNAS (T393C), and HSD3B1 (T?C Leu338)...
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    ..On the whole, our data demonstrate that the effects of orexin-A on the survival and function of human adrenocortical cells are mediated through the AKT signaling pathway. ..
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    ..Further studies demonstrated that the mRNA or protein levels of Leydig (Lhcgr, Scarb1, Star, Cyp11a1, Hsd3b1, Cyp17a1, Hsd17b3, and Hsd11b1), non-Leydig (Fshr and Dhh), and gonadotroph (Lhb) cells were also significantly ..
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    ..With the wildtype genotype as reference, men with HSD3B1 (c.1100 A/C) heterozygous genotype (hazard ratio (HR)=0.7, 95% confidence intervals (CI)=0.6, 0...
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    ..Three polymorphisms in separate genes (CYP19A1, HSD3B1, and HSD17B4) were significantly (P < ...
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    ..As the reverse was true for the human enzymes, gossypol might be useful for treating metastatic prostate cancer. ..
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    ..Progesterone formed from pregnenolone by 3β-hydroxysteroid dehydrogenase 1 (HSD3B1) and estradiol from androgen by aromatase (CYP19A1) are critical for the maintenance of pregnancy or associated ..
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    ..Also, our results suggest an attenuation of 3beta-HSD expression in EOC although further studies are required for confirmation. ..
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    ..increased 24-h-oscillations of serum testosterone and LC's cAMP levels, expression of Insl3, Per1, Star/StAR, Hsd3b1/2, Nur77, decreased Arr19 and canceled Per2 oscillatory expression pattern...
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    ..of the estrous cycle (CYP19A1, ESR2, PTGS2, HIF1A, and EDN1) and on days 12-14 of pregnancy (SCARB1, PGRMC1, STAR, HSD3B1, NR5A1, PTGFR, PTGER4, and VEGFA)...
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    ..Results of qPCR analysis revealed that expression of HSD3B2 mRNA was significantly higher than that of HSD3B1, and CYP11B1 mRNA was significantly higher than CYP11B2...
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  85. Stone J, Gurrin L, Byrnes G, Schroen C, Treloar S, Padilla E, et al. Mammographic density and candidate gene variants: a twins and sisters study. Cancer Epidemiol Biomarkers Prev. 2007;16:1479-84 pubmed
    ..We measured six single nucleotide polymorphisms from six candidate genes (COMT, HSD3B1, IGFBP3, HER2, XPD, and XRCC3)...
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    ..progesterone and estradiol secretion, and this was associated with an increase in the protein level of STAR, the HSD3B activity, and the phosphorylation levels of IGF1R and MAPK ERK1/2 in the presence or absence of IGF1 (10(-8) M)...
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    ..Thus, H156 in WT 1 vs. Y156 in WT 2 accounts for the substantially higher affinity of WT 1 3beta-HSD activity for these substrate and inhibitor steroids relative to the WT 2 enzyme. ..
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    ..case-control study was to estimate whether polymorphisms of the maternal estrogen synthesis genes (CYP19A1, HSD3B1 and HSD3B2) are associated with preeclampsia (PE) and gestational hypertension (GH)...
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    ..evaluate mRNA expression of receptors for LPS (TLR2, -4) and LH (LHCGR); the cytokine TNFA; steroidogenic (STAR, HSD3B), angiogenic (VEGFA121, FGF2), and vasoactive (EDN1) factors; and factors of prostaglandin synthesis (PGES, PGFS, ..
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