Gene Symbol: HSD17B4
Description: hydroxysteroid 17-beta dehydrogenase 4
Alias: DBP, MFE-2, MPF-2, PRLTS1, SDR8C1, peroxisomal multifunctional enzyme type 2, 17-beta-HSD 4, 17-beta-HSD IV, 17-beta-hydroxysteroid dehydrogenase 4, 17beta-estradiol dehydrogenase type IV, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase, D-3-hydroxyacyl-CoA dehydratase, D-bifunctional protein, peroxisomal, beta-hydroxyacyl dehydrogenase, beta-keto-reductase, hydroxysteroid dehydrogenase 4, multifunctional protein 2, peroxisomal multifunctional protein 2, short chain dehydrogenase/reductase family 8C member 1
Species: human
Products:     HSD17B4

Top Publications

  1. Koski K, Haapalainen A, Hiltunen J, Glumoff T. Crystal structure of 2-enoyl-CoA hydratase 2 from human peroxisomal multifunctional enzyme type 2. J Mol Biol. 2005;345:1157-69 pubmed
    2-Enoyl-CoA hydratase 2 is the middle part of the mammalian peroxisomal multifunctional enzyme type 2 (MFE-2), which is known to be important in the beta-oxidation of very-long-chain and alpha-methyl-branched fatty acids as well as in ..
  2. Pierce S, Walsh T, Chisholm K, Lee M, Thornton A, Fiumara A, et al. Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome. Am J Hum Genet. 2010;87:282-8 pubmed publisher
    ..sequencing of genomic DNA from one of these sisters revealed exactly one gene with two rare functional variants: HSD17B4, which encodes 17beta-hydroxysteroid dehydrogenase type 4 (HSD17B4), also known as D-bifunctional protein (DBP)...
  3. van Grunsven E, van Berkel E, Ijlst L, Vreken P, de Klerk J, Adamski J, et al. Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency. Proc Natl Acad Sci U S A. 1998;95:2128-33 pubmed
    ..The results show that the newly identified D-bifunctional protein plays an essential role in the peroxisomal beta-oxidation pathway that cannot be compensated for by the L-specific bifunctional protein. ..
  4. Haapalainen A, van Aalten D, Meriläinen G, Jalonen J, Pirilä P, Wierenga R, et al. Crystal structure of the liganded SCP-2-like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 A resolution. J Mol Biol. 2001;313:1127-38 pubmed
    ..In addition, the C-terminal peroxisomal targeting signal is ordered in the structure and solvent-exposed, which is not the case with unliganded rabbit SCP-2, supporting the hypothesis of a ligand-assisted targeting mechanism. ..
  5. Ferdinandusse S, Ylianttila M, Gloerich J, Koski M, Oostheim W, Waterham H, et al. Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis. Am J Hum Genet. 2006;78:112-24 pubmed
    D-bifunctional protein (DBP) deficiency is an autosomal recessive inborn error of peroxisomal fatty acid oxidation...
  6. Kashiwayama Y, Tomohiro T, Narita K, Suzumura M, Glumoff T, Hiltunen J, et al. Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative. J Biol Chem. 2010;285:26315-25 pubmed publisher
    ..Mass spectrometric analysis identified the 80-kDa protein as peroxisomal multifunctional enzyme type 2 (MFE2), one of the peroxisomal beta-oxidation enzymes...
  7. Grønborg S, Krätzner R, Spiegler J, Ferdinandusse S, Wanders R, Waterham H, et al. Typical cMRI pattern as diagnostic clue for D-bifunctional protein deficiency without apparent biochemical abnormalities in plasma. Am J Med Genet A. 2010;152A:2845-9 pubmed publisher
    ..The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established...
  8. McMillan H, Worthylake T, Schwartzentruber J, Gottlieb C, Lawrence S, MacKenzie A, et al. Specific combination of compound heterozygous mutations in 17?-hydroxysteroid dehydrogenase type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency. Orphanet J Rare Dis. 2012;7:90 pubmed publisher
    ..Ala34Val) and hydratase domain (c.1547T>C; p.Ile516Thr) of the 17?-hydroxysteroid dehydrogenase type 4 gene (HSD17B4)...
  9. Podfigurna A, Stellmach A, Szeliga A, Czyzyk A, Meczekalski B. Metabolic Profile of Patients with Premature Ovarian Insufficiency. J Clin Med. 2018;7: pubmed publisher
    ..glucose, insulin serum concentrations, HOMA-IR, as well as systolic (SBP) and diastolic blood pressure (DBP) did not differ significantly between both groups...

More Information

Publications149 found, 100 shown here

  1. Nascimento J, Mota C, Lacerda L, Pacheco S, Chorão R, Martins E, et al. D-bifunctional protein deficiency: a cause of neonatal onset seizures and hypotonia. Pediatr Neurol. 2015;52:539-43 pubmed publisher
    ..Asn457Tyr (N457Y) mutation of the HSD17B4 gene...
  2. Shridhar K, Satija A, Dhillon P, Agrawal S, Gupta R, Bowen L, et al. Association between empirically derived dietary patterns with blood lipids, fasting blood glucose and blood pressure in adults - the India migration study. Nutr J. 2018;17:15 pubmed publisher
    ..HDL-C), triglycerides, fasting-blood glucose (FBG), systolic and diastolic blood pressure (SBP and DBP) levels...
  3. Kassab R, Lokman M, Essawy E. Neurochemical alterations following the exposure to di-n-butyl phthalate in rats. Metab Brain Dis. 2019;34:235-244 pubmed publisher
    Due to its ability to cross blood brain barrier and placenta, dibutyl phthalate (di-n-butyl phthalate, DBP) is expected to cause severe side effects to the central nervous system of animals and humans...
  4. Zhang C, Liu Y, Qing E, Ma J. [Preoperative risk factors analysis of pulmonary hypertension crisis during perioperative period for caesarean section of woman with severe pulmonary hypertension]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:431-435 pubmed publisher
    ..sPAP) estimated by ultrasonic TI method, radial artery systolic blood pressure (SBP) and diastolic blood pressure (DBP), heart rate (HR), pulse oxygen saturation (SpO2) without oxygen, oral sildenafil ingestion, having Swan-..
  5. Lang I, Badr Eslam R, Greenlaw N, Young R, Steg P. Management and clinical outcome of stable coronary artery disease in Austria : Results from 5 years of the CLARIFY registry. Wien Klin Wochenschr. 2017;129:879-892 pubmed publisher
    ..After 5 years a systolic blood pressure (SBP) < 140?mm?Hg and diastolic blood pressure (DBP) < 90?mm?Hg was reached in 58.5% of patients. Of the patients 70.4% had LDL cholesterol plasma levels below 1...
  6. Chiang C, Wang T, Ueng K, Lin T, Yeh H, Chen C, et al. 2015 guidelines of the Taiwan Society of Cardiology and the Taiwan Hypertension Society for the management of hypertension. J Chin Med Assoc. 2015;78:1-47 pubmed publisher
    ..approximately a 10-mmHg decrease in systolic BP (SBP) (Rule of 10) and a 5-mmHg decrease in diastolic BP (DBP) (Rule of 5)...
  7. Li Q, Wu W, Lin H, Chang X, Bian H, Xia M, et al. Serum retinol binding protein 4 is negatively related to estrogen in Chinese women with obesity: a cross-sectional study. Lipids Health Dis. 2016;15:52 pubmed publisher
    ..with BMI, waist circumference, waist-to-hip ratio (WHR), systolic and diastolic (SBP), diastolic blood pressure (DBP), triglycerides (TG), low high-density lipoprotein cholesterol(LDL-c), and testosterone (TESTO) in the total group...
  8. Hetherington Rauth M, Bea J, Blew R, Funk J, Lee V, Roe D, et al. Relationship of cardiometabolic risk biomarkers with DXA and pQCT bone health outcomes in young girls. Bone. 2019;120:452-458 pubmed publisher
    ..low density lipoprotein cholesterol (LDL-C), triglyceride (TG), systolic and diastolic blood pressure (SBP and DBP), and C-reactive protein (CRP)...
  9. Miller M, Sorkin J, Mastella L, Sutherland A, Rhyne J, Donnelly P, et al. Poly is more effective than monounsaturated fat for dietary management in the metabolic syndrome: The muffin study. J Clin Lipidol. 2016;10:996-1003 pubmed publisher
    ..02), systolic blood pressure (BP) (-7 ± 3 mm Hg, P = .01), diastolic BP (DBP) (-4 ± 2 mm Hg, P = .01) and improved flow mediated dilation (FMD) (7.1% ± 1.8% vs 13...
  10. Li J, Wang L, Huang Z, Zhang M, Li Y, Wang W, et al. [Study on the relationship between BMI and the risk of cardiovascular among Chinese adults]. Zhonghua Liu Xing Bing Xue Za Zhi. 2014;35:977-80 pubmed
    ..23 both P < 0.001), respectively. The levels of systolic blood pressure (SBP), diastolic blood pressure (DBP), triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-..
  11. Liu Y, Zhao P, Cheng M, Yu L, Cheng Z, Fan L, et al. AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study. Lipids Health Dis. 2018;17:275 pubmed publisher
    ..After adjusting for potential confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose, TC, LDL, eGFR, smoking and exercise statuses, fatty liver, alcohol ..
  12. Jia L, Zhang H, Zhao Y, Li M, Li J, Zhang Z, et al. [Analysis of core indicators of fatal gastrointestinal rebleeding in emergency from the perspective of big data]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:1190-1195 pubmed publisher
    ..were screened out, 3 of which were vital signs, including systolic blood pressure (SBP), diastolic blood pressure (DBP), temperature (T); 7 key indicators of blood routine, including white blood cell count (WBC), eosinophil (EOS), ..
  13. Lü S, Zhou X, Zheng Q, Chen H, Geng Y. Platelet membrane receptor P2Y12 H1/H2 polymorphism is highly associated with cerebral infarction: a case-control study. Neuropsychiatr Dis Treat. 2018;14:2225-2231 pubmed publisher
    ..In contrast, significant differences were found between these two groups (P<0.01) in terms of SBP, DBP and plasma fibrinogen level...
  14. Suksomboon N, Poolsup N, Lin W. Effect of kiwifruit on metabolic health in patients with cardiovascular risk factors: a systematic review and meta-analysis. Diabetes Metab Syndr Obes. 2019;12:171-180 pubmed publisher
    ..selected if they evaluated the effect of kiwifruit in patients with cardiovascular risk factors and reported SBP, DBP, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein ..
  15. Frasinyuk M, Zhang W, Wyrebek P, Yu T, Xu X, Sviripa V, et al. Developing antineoplastic agents that target peroxisomal enzymes: cytisine-linked isoflavonoids as inhibitors of hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4). Org Biomol Chem. 2017;15:7623-7629 pubmed publisher
    ..the target of these agents as the bifunctional peroxisomal enzyme, hydroxysteroid 17β-dehydrogenase-4 (HSD17B4)...
  16. Li W, Yao M, Wang R, Shi Y, Hou L, Hou Z, et al. Profile of cardiac lipid metabolism in STZ-induced diabetic mice. Lipids Health Dis. 2018;17:231 pubmed publisher
    ..binding protein 3 (FABP3), palmitoyl transferase 1α (CPT-1α), acyl-CoA oxidase 1 (AOX1), D-bifunctional protein (DBP), 3-ketoacyl-CoA thiolase A (THLA), uncoupling protein (UCP) 2 and UCP3 were investigated by quantitative reverse-..
  17. Zglejc Waszak K, Waszkiewicz E, Franczak A. Periconceptional undernutrition affects the levels of DNA methylation in the peri-implantation pig endometrium and in embryos. Theriogenology. 2019;123:185-193 pubmed publisher
    ..receptor type B (EDNRB), regulator of G-protein signalling 12 (RGS12), type 4 17β-hydroxysteroid dehydrogenase (HSD17B4), toll-like receptor 3 (TLR3), and adiponectin receptor 1 (ADIPOR1)...
  18. Gordon Larsen P, Boone Heinonen J, Sidney S, Sternfeld B, Jacobs D, Lewis C. Active commuting and cardiovascular disease risk: the CARDIA study. Arch Intern Med. 2009;169:1216-23 pubmed publisher
    ..86 (95% CI, 0.78 to 0.93); difference in mean diastolic blood pressure (millimeters of mercury) (DBP(active)) - (DBP(nonactive)) = -1.67 (95% CI, -3.20 to -0...
  19. Zhu Y, Yang H, Diao Z, Li Y, Yan C. Reduced Serum Level of Interleukin-10 is Associated with Cerebral Infarction: A Case-Control and Meta-Analysis Study. Mol Neurobiol. 2016;53:2698-704 pubmed publisher
    ..high-density lipoprotein (HDL), creatinine (Cr), systolic blood pressure (SBP), and diastolic blood pressure (DBP), strongly correlated with CI development (all P < 0.05)...
  20. Liu X, Zhang N, Chen R, Zhao J, Yu P. Efficacy and safety of sodium-glucose cotransporter 2 inhibitors in type 2 diabetes: a meta-analysis of randomized controlled trials for 1 to 2years. J Diabetes Complications. 2015;29:1295-303 pubmed publisher
    ..528 to -1.220; I(2)=98.1%; for 2years result, WMD: -7.500; 95% CI: -7.698 to -7.302) and diastolic blood pressure (DBP) (for 1year result, WMD: -1.950; 95% CI: -2.890 to -1.010; I(2)=98.0%; for 2years result, WMD: -2.197; 95% CI: -3...
  21. Chen C, Dai J. Triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio and arterial stiffness in Japanese population: a secondary analysis based on a cross-sectional study. Lipids Health Dis. 2018;17:130 pubmed publisher
    ..The author only used this data for secondary analysis. After adjusting potential confounders (age, sex, BMI, SBP, DBP, AST, ALT, GGT, uric acid, fasting glucose, TC, LDL, eGFR, smoking and exercise status, fatty liver, alcohol ..
  22. Podolecka E, Grzeszczak W, Zukowska Szczechowska E. Correlation between serum low-density lipoprotein cholesterol concentration and arterial wall stiffness. Kardiol Pol. 2018;76:1712-1716 pubmed publisher
    ..Screening for dyslipidaemia in the general population and its prompt treatment are highly recom-mended. ..
  23. Nair N. Dose-dependent short-term study of di-n-butyl phthalate on the testicular antioxidant system of Wistar rats. Environ Sci Pollut Res Int. 2015;22:2196-204 pubmed publisher
    Di-n-butyl phthalate (DBP), a xenobiotic, is widely used in industries as a softener for polyvinyl chloride resins. The aim of the present study was to evaluate whether DBP induces oxidative stress in testes of Wistar rats...
  24. Wu J, Qiu L, Guo X, Xu T, Cheng X, Zhang L, et al. Apolipoprotein E gene polymorphisms are associated with primary hyperuricemia in a Chinese population. PLoS ONE. 2014;9:e110864 pubmed publisher
    ..genotype and the ε3 allele after adjustment for sex, body mass index (BMI), diastolic blood pressure (DBP), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), creatinine (Cr) and fasting blood glucose (FBG)...
  25. Cetin N, Sav N, Karabel D, Yildirim A, Yildiz B. Serum albumin and von Willebrand factor: possible markers for early detection of vascular damage in children undergoing peritoneal dialysis. Clin Invest Med. 2016;39:E111-9 pubmed
    ..high sensitive-CRP, hemoglobin, phosphorus and parathyroid hormone (PTH) levels, systolic (SBP) and diastolic (DBP) blood pressure, carotid intima-media thickness (cIMT) and left ventricular mass index (LVMI) were measured in 21 ..
  26. Yaya S, Ekholuenetale M, Bishwajit G. Differentials in prevalence and correlates of metabolic risk factors of non-communicable diseases among women in sub-Saharan Africa: evidence from 33 countries. BMC Public Health. 2018;18:1168 pubmed publisher
    ..Hypertension was defined as systolic blood pressure (SBP) ≥140 mmHg and/or diastolic blood pressure (DBP) ≥90 mmHg...
  27. Beltifa A, Feriani A, Machreki M, Ghorbel A, Ghazouani L, Di Bella G, et al. Plasticizers and bisphenol A, in packaged foods sold in the Tunisian markets: study of their acute in vivo toxicity and their environmental fate. Environ Sci Pollut Res Int. 2017;24:22382-22392 pubmed publisher
    ..products analyzed using GC-MS/MS indicated the presence of the benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP), diisodecyl phthalate (DiDP), diisononyl phthalate (DiNP), and 1,2-cyclohexane ..
  28. Jiang S, Bo L, Gong C, Du X, Kan H, Xie Y, et al. Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents. Int Arch Occup Environ Health. 2016;89:911-21 pubmed publisher
    ..60 times higher of systolic blood pressure (SBP) and 1.91 times higher of diastolic blood pressure (DBP). Contrary to the increase in above biological effects, there were 1.06 times lower of low frequency (LF), 1...
  29. Akinrinde A, Oyagbemi A, Omobowale T, Asenuga E, Ajibade T. Alterations in blood pressure, antioxidant status and caspase 8 expression in cobalt chloride-induced cardio-renal dysfunction are reversed by Ocimum gratissimum and gallic acid in Wistar rats. J Trace Elem Med Biol. 2016;36:27-37 pubmed publisher
    ..CoCl2 also produced significant reduction (p<0.05) in systolic (SBP), diastolic (DBP) and mean arterial (MAP) blood pressures. Oral COG and gallic acid treatment significantly reduced (p<0...
  30. Xu J, Boström A, Saeed M, Dubey R, Waeber G, Vollenweider P, et al. A genetic variant in the catechol-O-methyl transferase (COMT) gene is related to age-dependent differences in the therapeutic effect of calcium-channel blockers. Medicine (Baltimore). 2017;96:e7029 pubmed publisher
    ..metabolism in relation to sex- and age-specific differences in the systolic and diastolic blood pressure (SBP and DBP) outcome under the treatment of diuretics, calcium-channel blockers (CCBs), angiotensin-converting-enzyme ..
  31. Wang J, Zheng X, Sun M, Wang Z, Fu Q, Shi Y, et al. Low serum free thyroxine concentrations associate with increased arterial stiffness in euthyroid subjects: a population-based cross-sectional study. Endocrine. 2015;50:465-73 pubmed publisher
    ..076, P = 0.005). After adjusting for potential cardiovascular risk factors, mean diastolic blood pressure (DBP), HOMA-IR, and baPWV levels decreased across increasing FT4 quartiles (DBP, P < 0...
  32. Ying X, Jiang Y, Qin G, Qian Y, Shen X, Jiang Z, et al. Association of body mass index, waist circumference, and metabolic syndrome with serum cystatin C in a Chinese population. Medicine (Baltimore). 2017;96:e6289 pubmed publisher
    ..high sensitivity C-reactive protein (hs-CRP), BMI, WC, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine (Scr), and CysC were significantly higher, and HDL-C and the estimated glomerular filtration ..
  33. Yang J, Wei Q, Peng X, Peng X, Yuan J, Hu D. Relationship between Methyl Tertiary Butyl Ether Exposure and Non-Alcoholic Fatty Liver Disease: A Cross-Sectional Study among Petrol Station Attendants in Southern China. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..for age, gender, physical exercise, body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP), alanine aminotransferase (ALT), white blood cell (WBC), total cholesterol (TC), triglycerides (TG), low-density ..
  34. Nasreddine L, Tamim H, Mailhac A, Albuhairan F. Prevalence and predictors of metabolically healthy obesity in adolescents: findings from the national "Jeeluna" study in Saudi-Arabia. BMC Pediatr. 2018;18:281 pubmed publisher
    ..following traditional cardiometabolic risk (CR) factors: systolic blood pressure (SBP) or diastolic blood pressure (DBP) >90th percentile for age, sex, and height; triglycerides (TG) > 1...
  35. Popova E, Arkhipova N. [Metabolic risk factors in patients 60 years and older with arterial hypertension, living in extreme conditions of the Far North]. Adv Gerontol. 2015;28:561-566 pubmed
    ..Ethnic differences were found in SBP and DBP levels (p<0,001)...
  36. Muyumba E, Nkulu D, Mukeng C, Musung J, Kakoma P, Kakisingi C, et al. Oscillometric blood pressure by age and height for non overweight children and adolescents in Lubumbashi, Democratic Republic of Congo. BMC Cardiovasc Disord. 2018;18:9 pubmed publisher
    ..After excluding overweight and obese subjects according to the IOTF definition (n?=?640), gender-specific SBP and DBP percentiles, which simultaneously accounted for age and height by using an extension of the LMS method, namely ..
  37. Jarvis S, Okada Y, Levine B, Fu Q. Central integration and neural control of blood pressure during the cold pressor test: a comparison between hydrochlorothiazide and aliskiren. Physiol Rep. 2015;3: pubmed publisher
    ..women) subjects performed a CPT pre- and post treatment where heart rate (HR), systolic BP (SBP) and diastolic BP (DBP), and MSNA were measured. Blood samples were withdrawn for assessment of renal-adrenal hormones...
  38. Soldà G, Caccia S, Robusto M, Chiereghin C, Castorina P, Ambrosetti U, et al. First independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family. J Hum Genet. 2016;61:295-300 pubmed publisher
    ..Recently, mutations in five genes (HSD17B4, HARS2, CLPP, LARS2 and C10ORF2) were found to be responsible for Perrault syndrome, although they do not account ..
  39. Wickramasinghe V, Arambepola C, Bandara P, Abeysekera M, Kuruppu S, Dilshan P, et al. Defining Obesity Using a Biological End Point in Sri Lankan Children. Indian J Pediatr. 2017;84:117-123 pubmed publisher
    ..high density lipoprotein-cholesterol (HDL-C), triglyceride, and systolic and diastolic blood pressure (SBP/DBP)]. Receiver-Operator Characteristics (ROCs) were drawn to determine the best %FM that predicted MetS...
  40. Li J, Zou Q, Peng X. [Pharmacokinetics of a cisatracurium dose according to fat-free mass for anesthesia induction in morbidly obese patients]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:1396-1400 pubmed
    ..SBP, DBP, HR, MAP, SpO2 and PetCO2 were recorded before anesthetic induction (T0) and at 1 ..
  41. Šelmytė Besusparė A, Barysiene J, Petrikonytė D, Aidietis A, Marinskis G, Laucevicius A. Auscultatory versus oscillometric blood pressure measurement in patients with atrial fibrillation and arterial hypertension. BMC Cardiovasc Disord. 2017;17:87 pubmed publisher
    ..4?±?9.9 mmHg (AM), 83.5?±?11.8 mmHg (OM), p?=?0.037. The averages of differences for SBP and DBP in sinus rhythm group were (-5.3 mmHg (95% limits of agreement -27.2 - 16.6)) and (-1...
  42. Niewiński P, Janczak D, Ruciński A, Tubek S, Engelman Z, Jazwiec P, et al. Dissociation between blood pressure and heart rate response to hypoxia after bilateral carotid body removal in men with systolic heart failure. Exp Physiol. 2014;99:552-61 pubmed publisher
    ..Likewise, systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) slopes were calculated as slopes relating the lowest oxygen saturations to the highest SBP, ..
  43. Jiang J, Xu H, Zhu Y, Wood K, Li E, Sun W, et al. Reduced Fgf10/Fgfr2 and androgen receptor (AR) in anorectal malformations male rats induced by di-n-butyl phthalate (DBP): A study on the local and systemic toxicology of DBP. Toxicology. 2015;338:77-85 pubmed publisher
    ..the general conditions of anorectal malformations (ARMs) male rats are severely affected by di-n-butyl phthalate (DBP) maternal exposure. However, the mechanisms underlying DBP-induced congenital defects remain elusive...
  44. Gougoutsa C, Christophoridis C, Zacharis C, Fytianos K. Assessment, modeling and optimization of parameters affecting the formation of disinfection by-products in water. Environ Sci Pollut Res Int. 2016;23:16620-30 pubmed publisher
    ..in order to determine the main experimental variables affecting chlorinated and brominated disinfection by-product (DBP) formation in water during chlorination experiments and (b) the application of a central composite design (CCD) ..
  45. Qi X, Zhang Y, Pan J, Ma L, Wang L, Wang J. Effect of Bone Cement Implantation on Haemodynamics in Elderly Patients and Preventive Measure in Cemented Hemiarthroplasty. Biomed Res Int. 2015;2015:568019 pubmed publisher
    ..The monitoring indicators included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), and pulse oxygen saturation (SPO2)...
  46. Layne T, Weinstein S, Graubard B, Ma X, Mayne S, Albanes D. Serum 25-hydroxyvitamin D, vitamin D binding protein, and prostate cancer risk in black men. Cancer. 2017;123:2698-2704 pubmed publisher
    ..intervals (CIs) for the associations between serum 25-hydroxyvitamin D [25(OH)D], vitamin D binding protein (DBP), the 25(OH)D:DBP molar ratio, and prostate cancer risk...
  47. Usselman C, Skow R, Matenchuk B, Chari R, Julian C, Stickland M, et al. Sympathetic baroreflex gain in normotensive pregnant women. J Appl Physiol (1985). 2015;119:468-74 pubmed publisher
    ..01) relative to controls. Both mean (88 ± 3 vs. 91 ± 2 mmHg, P = 0.4) and diastolic (DBP) (72 ± 3 vs. 73 ± 2 mmHg, P = 0...
  48. Cao X, Zhao W, Dabeka R. Di-(2-ethylhexyl) adipate and 20 phthalates in composite food samples from the 2013 Canadian Total Diet Study. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32:1893-901 pubmed publisher
    ..most frequently, in 111 and 91 different food composite samples, respectively, followed by di-n-butyl phthalate (DBP) (n = 44), n-butyl benzyl phthalate (BBzP) (32), di-iso-butyl phthalate (DiBP) (27), di-ethyl phthalate (DEP) (3), ..
  49. Heitmar R, Kalitzeos A. Reliability of retinal vessel calibre measurements using a retinal oximeter. BMC Ophthalmol. 2015;15:184 pubmed publisher
    ..Participants were aged between 21 and 62 years, all were normotensive (SBP: 115 (12) mmHg; DBP: 72 (10) mmHg) and had normal intra-ocular pressures (12 (3) mmHg)...
  50. Xie Z, Wang J, Dai F, Jin X, Wu K, Chen Q, et al. Effects of maternal exposure to di-n-butyl phthalate during pregnancy and breastfeeding on ovarian development and function of F1 female rats. Environ Toxicol Pharmacol. 2016;43:38-43 pubmed publisher
    This study aimed to investigate the effects of maternal exposure to di-n-butyl phthalate (DBP) during pregnancy and breastfeeding on F1 ovarian development and function...
  51. Silvestrini N. On the implicit influence of pain cues on cognitive effort: Evidence from cardiovascular reactivity. Biol Psychol. 2018;132:45-54 pubmed publisher
    ..Effort was assessed as cardiovascular reactivity (PEP, SBP, DBP, and HR) during an easy or difficult cognitive task integrating briefly presented and masked pain-related words...
  52. Ozkan G, Ince M, Eşkin M, Erol G, Kadan M, Ozgur G, et al. Sedoanalgesia for cardioversion: comparison of alfentanil, remifentanil and fentanyl combined with propofol and midazolam: a prospective, randomized, double-blind study. Eur Rev Med Pharmacol Sci. 2016;20:1140-8 pubmed
    ..Hemodynamics and respiratory variables [Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), SpO2, respiratory rate (RR)], and Modified Aldrete recovery score (MARS) were ..
  53. Sokunbi G, Maduagwu S, Jaiyeola O, Gambo H, Blasu C. Cardiovascular Response to Manual Acupuncture Needle Stimulation among Apparently Healthy Nigerian Adults. J Acupunct Meridian Stud. 2016;9:143-50 pubmed publisher
    ..Changes in the DBP showed a significant difference between the SAG and the RAG (p > 0.05)...
  54. Zhang K, Fan G, Hu R, Li G. Enhanced Dibutyl Phthalate Sensing Performance of a Quartz Crystal Microbalance Coated with Au-Decorated ZnO Porous Microspheres. Sensors (Basel). 2015;15:21153-68 pubmed publisher
    ..This fabricated sensor was applied to detect dibutyl phthalate (DBP), which is a widely used plasticizer, and its coating load was optimized...
  55. Sampath S, Selvaraj K, Shanmugam G, Krishnamoorthy V, Chakraborty P, Ramaswamy B. Evaluating spatial distribution and seasonal variation of phthalates using passive air sampling in southern India. Environ Pollut. 2017;221:407-417 pubmed publisher
    ..Largely used phthalates, dibutylphthalate (DBP) and diethylhexlphthalate (DEHP) were predominantly found in all the seasons with contribution of 11-31% and 59-68%,..
  56. Chao H, Liao H, Kuo C. Using water plug-assisted analyte focusing by micelle collapse in combination with microemulsion electrokinetic chromatography for analyzing phthalate esters. J Chromatogr A. 2016;1445:149-57 pubmed publisher
    ..electrokinetic chromatography (WPA-AFMC-MEEKC) for quantifying benzyl butyl phthalate (BBP), dibutyl phthalate (DBP), diethylhexyl phthalate (DEHP), and diisodecyl phthalate (DIDP) in pediatric pharmaceuticals...
  57. Marsà A, Cortés C, Teixidó E, Hernandez A, Marcos R. In vitro studies on the tumorigenic potential of the halonitromethanes trichloronitromethane and bromonitromethane. Toxicol In Vitro. 2017;45:72-80 pubmed publisher
    ..Our results indicate that the carcinogenic effects of DBP mixtures cannot be attributed to the evaluated HNMs...
  58. Akarsu E, Korkmaz H, Oguzkan Balci S, Borazan E, Korkmaz S, Tarakcioglu M. Subcutaneous Adipose Tissue Type II Deiodinase Gene Expression Reduced in Obese Individuals with Metabolic Syndrome. Exp Clin Endocrinol Diabetes. 2016;124:11-5 pubmed publisher
    ..WC), waist-to-hip circumference ratio (WHR), hip circumference, and systolic (SBP) and diastolic blood pressures (DBP) of all subjects were recorded...
  59. Elliott J, Lal S. Blood Pressure, Sleep Quality and Fatigue in Shift Working Police Officers: Effects of a Twelve Hour Roster System on Cardiovascular and Sleep Health. Int J Environ Res Public Health. 2016;13:172 pubmed publisher
    ..001), but with no change found in females' diastolic blood pressure (DBP). Finally, higher pre and post-shift SBP (r = -0.26, p = 0.001; r = -0.25, p = 0.001, respectively) and DBP (r = -0...
  60. Tsai J, Wang J, Chen M, Yang C, Chen Y, Hsu B. Association of serum leptin levels with central arterial stiffness in coronary artery disease patients. BMC Cardiovasc Disord. 2016;16:80 pubmed publisher
    ..010), older age (P = 0.001), and higher systolic blood pressure (SBP) (P < 0.001), diastolic blood pressure (DBP) (P = 0.021), pulse pressure (P = 0.014), and serum leptin level (P = 0...
  61. Ayoola O, Gemmell I, Omotade O, Adeyanju O, Cruickshank J, Clayton P. Maternal malaria, birth size and blood pressure in Nigerian newborns: insights into the developmental origins of hypertension from the Ibadan growth cohort. PLoS ONE. 2011;6:e24548 pubmed publisher
    ..In contrast the mean newborn systolic (SBP) and diastolic BPs (DBP) adjusted for birth weight were higher by 1.7 and 1...
  62. Patterson A, Wadia S, Lorenz D, Stevenson M. Changes in blood pressure and heart rate during sedation with ketamine in the pediatric ED. Am J Emerg Med. 2017;35:322-325 pubmed publisher
    ..Linear mixed-effect models were used to evaluate changes in systolic BP (SBP), diastolic BP (DBP), and HR using 3 sedation strata: presedation (baseline), sedated (ketamine administered and patient deeply sedated)..
  63. Sun W, Zhu Y, Ni X, Jing D, Yao Y, Ding W, et al. Potential involvement of Fgf10/Fgfr2 and androgen receptor (AR) in renal fibrosis in adult male rat offspring subjected to prenatal exposure to di-n-butyl phthalate (DBP). Toxicol Lett. 2018;282:37-42 pubmed publisher
    We previously demonstrated that maternal exposure to di-n-butyl phthalate (DBP) induces dysplasia of the kidney in newborn male offspring and renal fibrosis in adults. But the underlying mechanisms remain elusive...
  64. Figueroa J, Sakoda L, Graubard B, Chanock S, Rubertone M, Erickson R, et al. Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors. Cancer Causes Control. 2008;19:917-29 pubmed publisher
    ..33 single nucleotide polymorphisms (SNPs) in four hormone metabolism candidate genes (CYP1A1, CYP17A1, HSD17B1, HSD17B4) and the androgen receptor gene (AR) were genotyped...
  65. He M, Yang C, Geng R, Zhao X, Hong L, Piao X, et al. Monitoring of phthalates in foodstuffs using gas purge microsyringe extraction coupled with GC-MS. Anal Chim Acta. 2015;879:63-8 pubmed publisher
    ..The concentrations were in the following order: DEHP>DBP>DEP≈DMP>BBP≈DNOP...
  66. Kovesdy C, Alrifai A, Gosmanova E, Lu J, Canada R, Wall B, et al. Age and Outcomes Associated with BP in Patients with Incident CKD. Clin J Am Soc Nephrol. 2016;11:821-31 pubmed publisher
    ..73 m(2), we examined associations of systolic BP (SBP) and diastolic BP (DBP) with all-cause mortality, incident coronary heart disease (CHD), ischemic strokes, and ESRD from the time of ..
  67. Morishita Y, Miura D, Kida S. PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter. Biosci Biotechnol Biochem. 2016;80:1131-40 pubmed publisher
    ..inhibition or shRNA-mediated knockdown of phosphatidylinositol 3-kinase (PI3K) blocked upregulation of Dbp mRNA induced by serum shock in NIH 3T3 cells...
  68. Shibata M, Sato K, Uehara S, Koh H, Kinuhata S, Oue K, et al. Blood pressure components and the risk for proteinuria in Japanese men: The Kansai Healthcare Study. J Epidemiol. 2017;27:505-510 pubmed publisher
    We examined prospectively which of the four blood pressure (BP) components (systolic BP [SBP], diastolic BP [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) was best in predicting the risk of proteinuria...
  69. Sofer T, Baier L, Browning S, Thornton T, Talavera G, Wassertheil Smoller S, et al. Admixture mapping in the Hispanic Community Health Study/Study of Latinos reveals regions of genetic associations with blood pressure traits. PLoS ONE. 2017;12:e0188400 pubmed publisher
    ..We performed admixture mapping of the blood pressure traits systolic and diastolic blood pressure (SBP, DBP), mean arterial pressure (MAP), and pulse pressure (PP), in a dataset of 12,116 participants from the Hispanic ..
  70. Kiani A, Ahmadloo M, Shariatifar N, Moazzen M, Baghani A, Khaniki G, et al. Method development for determination of migrated phthalate acid esters from polyethylene terephthalate (PET) packaging into traditional Iranian drinking beverage (Doogh) samples: a novel approach of MSPE-GC/MS technique. Environ Sci Pollut Res Int. 2018;25:12728-12738 pubmed publisher
    ..In this context, the quantity of the extractable migrated phthalate esters (dibutyl phthalate (DBP), dimethyl phthalate (DMP), butyl benzyl phthalate (BBP), diethyl phthalate (DEP), di-N-octyl phthalate (DNOP), and ..
  71. Huang Y, Wu Y, Cheng W, Peng S, Shen W, Chou C. Vitamin D-Binding Protein Enhances Epithelial Ovarian Cancer Progression by Regulating the Insulin-like Growth Factor-1/Akt Pathway and Vitamin D Receptor Transcription. Clin Cancer Res. 2018;24:3217-3228 pubmed publisher
    ..Vitamin D-binding protein (DBP) was revealed to be upregulated in EOC ascites in our previous proteomic study...
  72. Li C, Chen P, Duan X, Wang J, Shu B, Li X, et al. Bioavailable 25(OH)D but Not Total 25(OH)D Is an Independent Determinant for Bone Mineral Density in Chinese Postmenopausal Women. EBioMedicine. 2017;15:184-192 pubmed publisher
    ..populations; however, the bioavailability of 25(OH)D is regulated by the albumin and vitamin D binding protein (DBP) levels and DBP variations...
  73. Xie L, Liu B, Wang X, Mei M, Li M, Yu X, et al. Effects of different stresses on cardiac autonomic control and cardiovascular coupling. J Appl Physiol (1985). 2017;122:435-445 pubmed publisher
    ..In total, 25 male subjects were recruited. RR intervals (RRI), systolic and diastolic blood pressure (SBP, DBP), stroke volume (SV), cardiac output (CO), and systemic vascular resistance (SVR) values were collected during rest,..
  74. Li C, Wang D, Xu X, Wang Z. Formation of known and unknown disinfection by-products from natural organic matter fractions during chlorination, chloramination, and ozonation. Sci Total Environ. 2017;587-588:177-184 pubmed publisher
    ..Previous studies of the relationships between DBP formation and NOM fractionation have mainly been focused on currently regulated DBPs and a few certain emerging ..
  75. Oto A, Erdogan S, Bosnak M. Oxygen therapy via high flow nasal cannula in pediatric intensive care unit. Turk J Pediatr. 2016;58:377-382 pubmed
    ..parameters, respiratory rates (RR), heart rates (HR), systolic, db > iastolic, and mean arterial pressures (SBP, DBP, MAP), dyspnea scores, fractional oxygen indices (FiO < sub > 2 < /sub > ), and oxygen saturations (..
  76. Rahman M, Williams G, Al Mamun A. Gender differences in hypertension awareness, antihypertensive use and blood pressure control in Bangladeshi adults: findings from a national cross-sectional survey. J Health Popul Nutr. 2017;36:23 pubmed publisher
    ..One-in-three antihypertensive medication users had stage 2 hypertension (SBP ≥160/DBP ≥100 mmHg)...
  77. Junaid K, Rehman A, Jolliffe D, Wood K, Martineau A. High prevalence of vitamin D deficiency among women of child-bearing age in Lahore Pakistan, associating with lack of sun exposure and illiteracy. BMC Womens Health. 2015;15:83 pubmed publisher
    ..in genes encoding the vitamin D receptor, vitamin D 25-hydroxylase enzyme CYP2R1 and vitamin D binding protein [DBP] were investigated...
  78. Kjeldsen S, Berge E, Bangalore S, Messerli F, Mancia G, Holzhauer B, et al. No evidence for a J-shaped curve in treated hypertensive patients with increased cardiovascular risk: The VALUE trial. Blood Press. 2016;25:83-92 pubmed publisher
    Previous studies have debated the notion that low blood pressure (BP) during treatment, particularly diastolic (DBP), is associated with increased risk of cardiovascular disease...
  79. Goyal N, Tsivgoulis G, Pandhi A, Chang J, Dillard K, Ishfaq M, et al. Blood pressure levels post mechanical thrombectomy and outcomes in large vessel occlusion strokes. Neurology. 2017;89:540-547 pubmed publisher
    ..Hourly systolic BP (SBP) and diastolic BP (DBP) values were recorded for 24 hours following MT and maximum SBP and DBP levels were identified...
  80. McLeod K, Jain T. Postural Hypotension and Cognitive Function in Older Adults. Gerontol Geriatr Med. 2017;3:2333721417733216 pubmed publisher
    ..b>Results: Two thirds of our subjects were hypotensive (diastolic blood pressure [DBP] < 70 mmHg) after 30 min of quiet sitting...
  81. Qin P, Wang H, Yang X, He L, Muller K, Shaheen S, et al. Bamboo- and pig-derived biochars reduce leaching losses of dibutyl phthalate, cadmium, and lead from co-contaminated soils. Chemosphere. 2018;198:450-459 pubmed publisher
    Biochar effect on the potential mobility of dibutyl phthalate (DBP), cadmium (Cd), and lead (Pb) in co-contaminated soils is not well investigated...
  82. Costa A, Bosone D, Ramusino M, Ghiotto N, Guaschino E, Zoppi A, et al. Twenty-four-hour blood pressure profile, orthostatic hypotension, and cardiac dysautonomia in elderly type 2 diabetic hypertensive patients. Clin Auton Res. 2016;26:433-439 pubmed
    ..defined as a decrease in systolic blood pressure (SBP) ?20 mmHg and/or a decrease in diastolic blood pressure (DBP) ?10 mmHg, and 24-h ambulatory BP profile in elderly hypertensive type 2 diabetic patients...
  83. Kim S, Chang B, Jeong B, Park H, Jeon K, Shin S, et al. Implication of vitamin D-associated factors in patients with non-tuberculous mycobacterial lung disease. Int J Tuberc Lung Dis. 2016;20:1594-1602 pubmed
    ..levels of 25-hydroxyvitamin D (25[OH]D), cathelicidin (LL-37), defensin (hBD-2) and vitamin D-binding protein (DBP) from 82 patients with NTM lung disease and 28 control subjects were analysed...
  84. Ma L, Li Y. The effect of depression on sleep quality and the circadian rhythm of ambulatory blood pressure in older patients with hypertension. J Clin Neurosci. 2017;39:49-52 pubmed publisher
    ..In the case group, 24h ambulatory SBP and DBP, and nocturnal SBP and DBP were higher than in the control group, and the circadian rhythm of non-dipper was higher ..
  85. Nifant ev I, Shlyakhtin A, Bagrov V, Minyaev M, Churakov A, Karchevsky S, et al. Mono-BHT heteroleptic magnesium complexes: synthesis, molecular structure and catalytic behavior in the ring-opening polymerization of cyclic esters. Dalton Trans. 2017;46:12132-12146 pubmed publisher
    ..The free energies of model dimeric [(DBP)Mg(μ-OMe)(Sub)]2 and monomeric (DBP)Mg(OMe)(Sub)2 products on treatment of [(DBP)Mg(μ-..
  86. Yu D, Fu P, Yu W, Guo H, Yang X, Zhao W, et al. [Mean blood pressure among the adults in China 2010-2012: based on the results of mercury sphygmomanometer and converted electronic sphygmomanometer]. Zhonghua Yu Fang Yi Xue Za Zhi. 2017;51:933-938 pubmed publisher
    b>Objective: To analyze the average systolic blood pressure (SBP) and diastolic blood pressure (DBP) among adults aged 18 years old and above in China between 2010 and 2012; and to compare the difference in the results measured by ..
  87. Mancia G, Cannon C, Tikkanen I, Zeller C, Ley L, Woerle H, et al. Impact of Empagliflozin on Blood Pressure in Patients With Type 2 Diabetes Mellitus and Hypertension by Background Antihypertensive Medication. Hypertension. 2016;68:1355-1364 pubmed
    ..present analysis investigated changes from baseline to week 12 in mean 24-hour systolic BP (SBP) and diastolic BP (DBP) in patients receiving 0, 1, or ?2 antihypertensive medications and patients receiving/not receiving diuretics or ..
  88. Jiang L, Kurosawa T, Sato M, Suzuki Y, Hashimoto T. Physiological role of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein. J Biochem. 1997;121:506-13 pubmed
  89. Zha S, Ferdinandusse S, Hicks J, Denis S, Dunn T, Wanders R, et al. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. Prostate. 2005;63:316-23 pubmed
    ..downstream from AMACR in the peroxisomal branched chain fatty acid beta-oxidation pathway-D-bifunctional protein (DBP)-is also upregulated in prostate cancer at both mRNA and protein levels, accompanied by increased enzymatic ..
  90. Ma X, Deng J, Feng J, Shanaiah N, Smiley E, Dietrich A. Identification and characterization of phenylacetonitrile as a nitrogenous disinfection byproduct derived from chlorination of phenylalanine in drinking water. Water Res. 2016;102:202-210 pubmed publisher
    ..The major N-DBP identified was phenylacetonitrile, and minor DBPs of benzyl chloride, phenylacetaldehyde, 2-chlorobenzyl cyanide, ..
  91. Gholoobi A, Ayati N, Baghyari A, Mouhebati M, Atar B, Dabbagh Kakhki V. Relationship between gated myocardial perfusion SPECT findings and hemodynamic, electrocardiographic, and heart rate changes after Dipyridamole infusion. Int J Cardiovasc Imaging. 2017;33:951-956 pubmed publisher
    ..Systolic blood pressure (SBP), diastolic blood pressure (DBP), HR and ECG were recorded...
  92. Wang M, Helbling D. A non-target approach to identify disinfection byproducts of structurally similar sulfonamide antibiotics. Water Res. 2016;102:241-251 pubmed publisher
    ..In total, 11, 12, and 15 DBP structures were proposed for sulfamethoxazole, sulfathiazole, and sulfadimethoxine, respectively...