HSD17B1

Summary

Gene Symbol: HSD17B1
Description: hydroxysteroid 17-beta dehydrogenase 1
Alias: 17-beta-HSD, 20-alpha-HSD, E2DH, EDH17B2, EDHB17, HSD17, SDR28C1, estradiol 17-beta-dehydrogenase 1, 17-beta-HSD 1, 17-beta-hydroxysteroid dehydrogenase type 1, 20 alpha-hydroxysteroid dehydrogenase, placental 17-beta-hydroxysteroid dehydrogenase, short chain dehydrogenase/reductase family 28C member 1, short chain dehydrogenase/reductase family 28CE, member 1
Species: human
Products:     HSD17B1

Top Publications

  1. Luu The V, Labrie C, Simard J, Lachance Y, Zhao H, Couet J, et al. Structure of two in tandem human 17 beta-hydroxysteroid dehydrogenase genes. Mol Endocrinol. 1990;4:268-75 pubmed
    ..These new findings provide the basis for a better understanding of the molecular mechanisms involved in 17 beta-HSD deficiency and peripheral sex steroid metabolism. ..
  2. Luu The V, Labrie C, Zhao H, Couet J, Lachance Y, Simard J, et al. Characterization of cDNAs for human estradiol 17 beta-dehydrogenase and assignment of the gene to chromosome 17: evidence of two mRNA species with distinct 5'-termini in human placenta. Mol Endocrinol. 1989;3:1301-9 pubmed
    Human placenta estradiol 17 beta-dehydrogenase (E2DH) cDNA clones were isolated from a lambda gt11 expression library by screening with 33 mer synthetic oligonucleotides derived from the amino acid sequence of the catalytic site of E2DH ..
  3. Jansson A, Gunnarsson C, Stal O. Proliferative responses to altered 17beta-hydroxysteroid dehydrogenase (17HSD) type 2 expression in human breast cancer cells are dependent on endogenous expression of 17HSD type 1 and the oestradiol receptors. Endocr Relat Cancer. 2006;13:875-84 pubmed
    ..Expression of 17HSD type 1 seems to be dominant to 17HSD type 2. Therefore, it may be important to investigate a ratio between 17HSD type 1 and 17HSD type 2. ..
  4. Gunnarsson C, Jerevall P, Hammar K, Olsson B, Nordenskjold B, Jansson A, et al. Amplification of HSD17B1 has prognostic significance in postmenopausal breast cancer. Breast Cancer Res Treat. 2008;108:35-41 pubmed
    ..The gene coding for 17beta-HSD type 1 (HSD17B1) is located at 17q12-21...
  5. Aka J, Mazumdar M, Chen C, Poirier D, Lin S. 17beta-hydroxysteroid dehydrogenase type 1 stimulates breast cancer by dihydrotestosterone inactivation in addition to estradiol production. Mol Endocrinol. 2010;24:832-45 pubmed publisher
    ..These results strongly support the rationale for inhibiting 17beta-HSD1 in breast cancer therapy to eliminate estrogen activation via the sulfatase pathway while avoiding the deprivation of DHT. ..
  6. Wu A, Seow A, Arakawa K, Van Den Berg D, Lee H, Yu M. HSD17B1 and CYP17 polymorphisms and breast cancer risk among Chinese women in Singapore. Int J Cancer. 2003;104:450-7 pubmed
    ..Study Cohort, the relationships between polymorphisms in 2 genes involved in estrogen metabolism, CYP17 and HSD17B1, and the risk of breast cancer...
  7. Setiawan V, Hankinson S, Colditz G, Hunter D, De Vivo I. HSD17B1 gene polymorphisms and risk of endometrial and breast cancer. Cancer Epidemiol Biomarkers Prev. 2004;13:213-9 pubmed
    Estrogen exposure influences breast and endometrial cancer risk. The HSD17B1 gene produces an enzyme that catalyzes the conversion of estrone to estradiol...
  8. Warren R, Skinner J, Sala E, Denton E, Dowsett M, Folkerd E, et al. Associations among mammographic density, circulating sex hormones, and polymorphisms in sex hormone metabolism genes in postmenopausal women. Cancer Epidemiol Biomarkers Prev. 2006;15:1502-8 pubmed
    ..SHBG), androstenedione, 17-OH-progesterone, estrone, and estrone sulfate] and 15 SNPs in the CYP17, CYP19, EDH17B2, SHBG, COMT, and CYP1B1 genes were studied...
  9. Chanplakorn N, Chanplakorn P, Suzuki T, Ono K, Chan M, Miki Y, et al. Increased estrogen sulfatase (STS) and 17beta-hydroxysteroid dehydrogenase type 1(17beta-HSD1) following neoadjuvant aromatase inhibitor therapy in breast cancer patients. Breast Cancer Res Treat. 2010;120:639-48 pubmed publisher
    ..This increment may represent the compensatory response of breast carcinoma tissues to estrogen depletion. ..

More Information

Publications142 found, 100 shown here

  1. Peltoketo H, Isomaa V, Mäentausta O, Vihko R. Complete amino acid sequence of human placental 17 beta-hydroxysteroid dehydrogenase deduced from cDNA. FEBS Lett. 1988;239:73-7 pubmed
    ..The deduced amino acid sequence also contained two peptides previously characterized from the proposed catalytic area of placental 17-HSD. ..
  2. Ghosh D, Pletnev V, Zhu D, Wawrzak Z, Duax W, Pangborn W, et al. Structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase at 2.20 A resolution. Structure. 1995;3:503-13 pubmed
    ..The structure of the active site provides a rational basis for designing more specific inhibitors of this breast cancer associated enzyme. ..
  3. Azzi A, Rehse P, Zhu D, Campbell R, Labrie F, Lin S. Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol. Nat Struct Biol. 1996;3:665-8 pubmed
  4. Olson S, Bandera E, Orlow I. Variants in estrogen biosynthesis genes, sex steroid hormone levels, and endometrial cancer: a HuGE review. Am J Epidemiol. 2007;165:235-45 pubmed
    ..P-450 genes CYP11A1 (-528[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta-hydroxysteroid dehydrogenase 1 gene HSD17B1 (Ser312Gly) and levels of progesterone, androgens, or estrogens...
  5. Moeller G, Adamski J. Integrated view on 17beta-hydroxysteroid dehydrogenases. Mol Cell Endocrinol. 2009;301:7-19 pubmed publisher
    ..Strategies on deciphering the physiological role of 17beta-HSDs and the genetic predisposition for associated diseases will be presented. ..
  6. Jansson A, Delander L, Gunnarsson C, Fornander T, Skoog L, Nordenskjold B, et al. Ratio of 17HSD1 to 17HSD2 protein expression predicts the outcome of tamoxifen treatment in postmenopausal breast cancer patients. Clin Cancer Res. 2009;15:3610-6 pubmed publisher
    ..Our data suggest that the 17HSD1/17HSD2 ratio might be useful as a predictive factor for tamoxifen treatment in ER-positive breast cancer patients. ..
  7. Sherbet D, Guryev O, Papari Zareei M, Mizrachi D, Rambally S, Akbar S, et al. Biochemical factors governing the steady-state estrone/estradiol ratios catalyzed by human 17beta-hydroxysteroid dehydrogenases types 1 and 2 in HEK-293 cells. Endocrinology. 2009;150:4154-62 pubmed publisher
    ..These findings suggest that additional structural features, beyond the lack of a specific arginine residue, disfavor NADPH binding and thus support E2 oxidation by 17betaHSD2 in intact cells. ..
  8. Zhang C, Chen J, Yin D, Lin S. The contribution of 17beta-hydroxysteroid dehydrogenase type 1 to the estradiol-estrone ratio in estrogen-sensitive breast cancer cells. PLoS ONE. 2012;7:e29835 pubmed publisher
    ..Moreover, kinetic studies were carried out in intact cells as a new approach, using HEK-293 cells over-expressing type 1 and T47D breast cancer cells. ..
  9. Sawetawan C, Milewich L, Word R, Carr B, Rainey W. Compartmentalization of type I 17 beta-hydroxysteroid oxidoreductase in the human ovary. Mol Cell Endocrinol. 1994;99:161-8 pubmed
    ..Both theca interna and granulosa cells of preantral and antral follicles exhibited 3 beta-HSD staining. Primary follicles did not exhibit detectable 3 beta-HSD in either granulosa or theca cells.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  10. Craig Z, Leslie T, Hatfield K, Gupta R, Flaws J. Mono-hydroxy methoxychlor alters levels of key sex steroids and steroidogenic enzymes in cultured mouse antral follicles. Toxicol Appl Pharmacol. 2010;249:107-13 pubmed publisher
    ..90±3.75 ng/mL; 10 μg/mL: 9.44±2.97 ng/mL) levels. Mono-OH did not alter expression of Star, Hsd3b1, Hsd17b1 and Cyp1b1, but it did reduce levels of Cyp11a1, Cyp17a1 and Cyp19a1 mRNA...
  11. Lerner A, Owens L, Coates M, Simpson C, Poole G, Velupillai J, et al. Expression of genes controlling steroid metabolism and action in granulosa-lutein cells of women with polycystic ovaries. Mol Cell Endocrinol. 2019;486:47-54 pubmed publisher
    ..GL cells from women with PCOS showed reduced expression of CYP11A1 3-fold (p = 0.005), HSD17B1 1.8-fold (p = 0.02) and increased expression of SULT1E1 7-fold (p = 0.0003)...
  12. Zhou R, Lu G, Yan Z, Jiang R, Shen J, Bao X. Parental transfer of ethylhexyl methoxy cinnamate and induced biochemical responses in zebrafish. Aquat Toxicol. 2019;206:24-32 pubmed publisher
    ..contents, the expression levels of Vtg1, P450 aromatase (Cyp19a and Cyp19b), 17β-hydroxysteroid dehydrogenase (Hsd17b1, Hsd17b3), estrogen receptor-alpha and progesterone receptor in all concentration groups decreased significantly, ..
  13. Sainz J, Rudolph A, Hein R, Hoffmeister M, Buch S, von Schönfels W, et al. Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk. Endocr Relat Cancer. 2011;18:265-76 pubmed publisher
    ..in steroid hormone signaling (ESR1, ESR2, PGR, NR1I2, and SHBG), phase I- and II-metabolizing enzyme (COMT, HSD17B1, CYP1A1, CYP17A1, CYP1A2, CYP1B1, CYP2C9, CYP3A4, CYP2C19, and GSTP1), and hormone transporter (ABCB1) genes with ..
  14. Han H, Thériault J, Chen G, Lin S. Substrate inhibition of 17?-HSD1 in living cells and regulation of 17?-HSD7 by 17?-HSD1 knockdown. J Steroid Biochem Mol Biol. 2017;172:36-45 pubmed publisher
    ..We also demonstrated the central role of 17?-HSD7 in sex-hormone conversion and regulation, supporting it as a novel target for estrogen-dependent (ER+) BC. ..
  15. Bai Y, Zhou W, Mu X, Zhang Q, Yu C, Di B, et al. Covalent Immobilization of Human Placental 17?-Hydroxysteroid Dehydrogenase Type 1 onto Glutaraldehyde Activated Silica Coupled with LC-TOF/MS for Anti-Cancer Drug Screening Applications. Appl Biochem Biotechnol. 2017;182:482-494 pubmed publisher
    ..Subsequently, 10 natural products were evaluated leading to inhibition of the activity of 17?-HSD1 at the concentration of 25 ?M, and six of them inhibit the activity over 50%. ..
  16. Osiński M, Wirstlein P, Wender Ozegowska E, Mikołajczyk M, Jagodziński P, Szczepańska M. HSD3B2, HSD17B1, HSD17B2, ESR1, ESR2 and AR expression in infertile women with endometriosis. Ginekol Pol. 2018;89:125-134 pubmed publisher
    ..However, little is known about the expression of HSD3B2, HSD17B1, HSD17B2, ESR1 ESR2 and AR during the endometrial phases in eutopic endometrium from infertile women with ..
  17. Freedman N, Ahn J, Hou L, Lissowska J, Zatonski W, Yeager M, et al. Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer. Carcinogenesis. 2009;30:71-7 pubmed publisher
    ..of gastric cancer with single-nucleotide polymorphisms (SNPs) in six genes (COMT, CYP1B1, CYP17A1, CYP19A1, HSD17B1 and SHBG) involved in estrogen and androgen synthesis and metabolism, 58 haplotype-tagging SNPs were genotyped in ..
  18. Hakkarainen J, Jokela H, Pakarinen P, Heikelä H, Kätkänaho L, Vandenput L, et al. Hydroxysteroid (17β)-dehydrogenase 1-deficient female mice present with normal puberty onset but are severely subfertile due to a defect in luteinization and progesterone production. FASEB J. 2015;29:3806-16 pubmed publisher
    Hydroxysteroid (17β)-dehydrogenase type 1 (HSD17B1) catalyzes the conversion of low active 17-ketosteroids, androstenedione (A-dione) and estrone (E1) to highly active 17-hydroxysteroids, testosterone (T) and E2, respectively...
  19. Zhu H, Huang L, He Z, Zou Z, Luo Y. Estrogen-related receptor γ regulates expression of 17β-hydroxysteroid dehydrogenase type 1 in fetal growth restriction. Placenta. 2018;67:38-44 pubmed publisher
    Estrogen-related receptor γ (ERRγ) and 17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) have important roles in cell invasion and in the proliferation of many types of cancer cells...
  20. Murdock G, Chin C, Offord R, Bradshaw R, Warren J. Human placental estradiol 17 beta-dehydrogenase. Identification of a single histidine residue affinity-labeled by both 3-bromoacetoxyestrone and 12 beta-bromoacetoxy-4-estrene-3,17-dione. J Biol Chem. 1983;258:11460-4 pubmed
    ..It is concluded that the steroid-binding site of human placental estradiol 17 beta-dehydrogenase contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step. ..
  21. Andersson S, Geissler W, Patel S, Wu L. The molecular biology of androgenic 17 beta-hydroxysteroid dehydrogenases. J Steroid Biochem Mol Biol. 1995;53:37-9 pubmed
    ..The 17 beta-HSD3 gene is mutated in male pseudohermaphrodites with the genetic disease 17 beta-HSD deficiency. ..
  22. Gangloff A, Shi R, Nahoum V, Lin S. Pseudo-symmetry of C19 steroids, alternative binding orientations, and multispecificity in human estrogenic 17beta-hydroxysteroid dehydrogenase. FASEB J. 2003;17:274-6 pubmed
  23. Adibi J, Buckley J, Lee M, Williams P, Just A, Zhao Y, et al. Maternal urinary phthalates and sex-specific placental mRNA levels in an urban birth cohort. Environ Health. 2017;16:35 pubmed publisher
    ..We measured candidate mRNAs in 180 placentas sampled at birth (HSD17B1, AHR, CGA, CYP19A1, SLC27A4, PTGS2, PPARG, CYP11A1) by quantitative PCR and an absolute standard curve...
  24. Vizziano Cantonnet D, Lasalle A, Di Landro S, Klopp C, Genthon C. De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon. Gen Comp Endocrinol. 2018;268:96-109 pubmed publisher
    ..These newly-reported genes are involved in stem-cell niche building and regulation as well as sex-specific nerve development. ..
  25. Friedberg M, Zoumakis E, Hiroi N, Bader T, Chrousos G, Hochberg Z. Modulation of 11 beta-hydroxysteroid dehydrogenase type 1 in mature human subcutaneous adipocytes by hypothalamic messengers. J Clin Endocrinol Metab. 2003;88:385-93 pubmed
  26. Obazee O, Justenhoven C, Winter S, Chang Claude J, Rudolph A, Seibold P, et al. Confirmation of the reduction of hormone replacement therapy-related breast cancer risk for carriers of the HSD17B1_937_G variant. Breast Cancer Res Treat. 2013;138:543-8 pubmed publisher
    17β-hydroxysteroid dehydrogenase type 1 (HSD17B1) plays an important role in the biosynthesis of 17β-estradiol...
  27. Ntostis P, Agiannitopoulos K, Tsaousis G, Pantos K, Lamnissou K. Evidence for association of the rs605059 polymorphism of HSD17B1 gene with recurrent spontaneous abortions. J Matern Fetal Neonatal Med. 2015;28:2250-3 pubmed publisher
    To investigate whether the missense rs605059 polymorphism of HSD17B1 gene, which is expressed mainly in the placenta, is associated with recurrent spontaneous abortions (RSA)...
  28. Donaubauer E, Hunzicker Dunn M. Extracellular Signal-regulated Kinase (ERK)-dependent Phosphorylation of Y-Box-binding Protein 1 (YB-1) Enhances Gene Expression in Granulosa Cells in Response to Follicle-stimulating Hormone (FSH). J Biol Chem. 2016;291:12145-60 pubmed publisher
    ..dephospho-adenoviral-YB-1(S102A) mutant prevented the induction by FSH of Egfr, Cyp19a1, Inha, Lhcgr, Cyp11a1, Hsd17b1, and Pappa mRNAs and estradiol-17? production...
  29. Teasdale S, Morton A. Adrenarche unmasks compound heterozygous 3?-hydroxysteroid dehydrogenase deficiency: c.244G>A (p.Ala82Thr) and the novel 931C>T (p.Gln311*) variant in a non-salt wasting, severely undervirilised 46XY. J Pediatr Endocrinol Metab. 2017;30:355-360 pubmed publisher
    ..It also demonstrates how current guidelines based on urinary steroids and cortisol sufficiency may not arrive at the correct diagnosis, and underlines the importance of gene testing in the work-up of disorders of sexual differentiation. ..
  30. Mazza C, Breton R, Housset D, Fontecilla Camps J. Unusual charge stabilization of NADP+ in 17beta-hydroxysteroid dehydrogenase. J Biol Chem. 1998;273:8145-52 pubmed
    ..Analysis of the catalytic properties of, and estradiol binding to, the two mutants suggests that the His221-steroid O3 hydrogen bond plays an important role in substrate specificity. ..
  31. Beesley J, Jordan S, Spurdle A, Song H, Ramus S, Kjaer S, et al. Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation set. Cancer Epidemiol Biomarkers Prev. 2007;16:2557-65 pubmed
    ..Further analyses of SNPs in this gene are therefore warranted to determine whether SRD5A2 plays a role in ovarian cancer predisposition...
  32. Wang Y, Li H, Li J, Yuan P, Yang F, Lei F, et al. [Relationship between estrogen-biosynthesis gene (CYP17, CYP19, HSD17beta1) polymorphisms and breast cancer]. Zhonghua Zhong Liu Za Zhi. 2009;31:899-903 pubmed
    ..52, 95%CI = 1.54 to 4.11). The estrogen-biosynthesis genes CYP17 (T1931C) and HSD17beta1 (A1954G) polymorphism may jointly increase the risk of breast cancer. ..
  33. Olivo Marston S, Mechanic L, Mollerup S, Bowman E, Remaley A, Forman M, et al. Serum estrogen and tumor-positive estrogen receptor-alpha are strong prognostic classifiers of non-small-cell lung cancer survival in both men and women. Carcinogenesis. 2010;31:1778-86 pubmed publisher
    ..Understanding the genetic control of estrogen biosynthesis and response in lung cancer could lead to improved prognosis and therapy. ..
  34. Hevir Kene N, Rižner T. The endometrial cancer cell lines Ishikawa and HEC-1A, and the control cell line HIEEC, differ in expression of estrogen biosynthetic and metabolic genes, and in androstenedione and estrone-sulfate metabolism. Chem Biol Interact. 2015;234:309-19 pubmed publisher
    ..cells showed statistically significant different gene expression profiles for SULT2B1, HSD3B2, CYP19A1, AKR1C3, HSD17B1, HSD17B7, HSD17B12, CYP1B1, CYP3A5, COMT, SULT1A1, GSTP1 and NQO2...
  35. Suzuki M, Muto S, Hara K, Ozeki T, Yamada Y, Kadowaki T, et al. Single-nucleotide polymorphisms in the 17beta-hydroxysteroid dehydrogenase genes might predict the risk of side-effects of estramustine phosphate sodium in prostate cancer patients. Int J Urol. 2005;12:166-72 pubmed
    ..13, 95% CI: 1.15-72.76). These preliminary data demonstrated that analyses of SNP in the HSD17B genes might predict the occurrence of side-effects from EMP. ..
  36. Sangrajrang S, Sato Y, Sakamoto H, Ohnami S, Laird N, Khuhaprema T, et al. Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women. Int J Cancer. 2009;125:837-43 pubmed publisher
    ..polymorphisms (SNPs) in the CYP1A1, CYP1A2, CYP1B1, CYP17, CYP19, CYP2C9, CYP2C19, AhR, ESR1, PGR, ERRG, COMT, HSD17B1, HSD17B2, EPHX1 and NQO1 genes were genotyped...
  37. Klein T, Henn C, Negri M, Frotscher M. Structural basis for species specific inhibition of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1): computational study and biological validation. PLoS ONE. 2011;6:e22990 pubmed publisher
    ..Additionally, it facilitates inhibitor design and optimization by offering new information on protein-ligand interactions. ..
  38. Suasnavas E, Heywood S, Ward A, Cox L, O Grady M, Zhao Y, et al. Isolation and characterization of trophoblast-derived stem-like cells from peri-implantation porcine embryos. Anim Reprod Sci. 2015;154:128-41 pubmed publisher
    ..and relative abundance) of mRNA transcripts from genes involved in trophoblast function (CDX2, TEAD4, CYP17A1, HSD17B1, FGFR2, PLET, HAND1) as well as some genes known to mediate pluripotency (POU5F1, KLF4, CMYC)...
  39. Wen Q, Zheng Q, Li X, Hu Z, Gao F, Cheng C, et al. Wt1 dictates the fate of fetal and adult Leydig cells during development in the mouse testis. Am J Physiol Endocrinol Metab. 2014;307:E1131-43 pubmed publisher
    ..Deletion of Wt1 gene also perturbed the expression of steroidogenic enzymes Star, P450c17, Hsd3b6, Hsd3b1, Hsd17b1, and Hsd17b3...
  40. Lutkowska A, Roszak A, Jagodzinski P. 17?-hydroxysteroid dehydrogenase type Gene 1937 A > G Polymorphism as a Risk Factor for Cervical Cancer Progression in the Polish Population. Pathol Oncol Res. 2017;23:317-322 pubmed publisher
    ..17? Hydroxysteroid dehydrogenase type 1 (HSD17B1) converts estrone (E1) into E2...
  41. Luu The V, Labrie C, Zhao H, Couet J, Lachance Y, Simard J, et al. Purification, cloning, complementary DNA structure, and predicted amino acid sequence of human estradiol 17 beta-dehydrogenase. Ann N Y Acad Sci. 1990;595:40-52 pubmed
  42. Blomquist C. Kinetic analysis of enzymic activities: prediction of multiple forms of 17 beta-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol. 1995;55:515-24 pubmed
    ..Mouse ovary appears to contain forms of 17 beta-HSD which differ from 17 beta-HSD type 1 and type 2 in their kinetic properties. ..
  43. Haller F, Moman E, Hartmann R, Adamski J, Mindnich R. Molecular framework of steroid/retinoid discrimination in 17beta-hydroxysteroid dehydrogenase type 1 and photoreceptor-associated retinol dehydrogenase. J Mol Biol. 2010;399:255-67 pubmed publisher
    ..This has implications for the validation of inhibitors of 17beta-HSD1 developed for cancer treatment. ..
  44. Verma M, Miki Y, Abe K, Suzuki T, Niikawa H, Suzuki S, et al. Intratumoral localization and activity of 17?-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer: a potent prognostic factor. J Transl Med. 2013;11:167 pubmed publisher
    ..Results of our present study suggest that 17?HSD1 may be considered an important prognostic factor in NSCLC patients and targeting 17?HSD1 activity may further improve the clinical response in estrogen responsive NSCLC patients. ..
  45. Leon L, Bacallao K, Gabler F, Romero C, Valladares L, Vega M. Activities of steroid metabolic enzymes in secretory endometria from untreated women with Polycystic Ovary Syndrome. Steroids. 2008;73:88-95 pubmed
  46. Kruchten P, Werth R, Bey E, Oster A, Marchais Oberwinkler S, Frotscher M, et al. Selective inhibition of 17beta-hydroxysteroid dehydrogenase type 1 (17betaHSD1) reduces estrogen responsive cell growth of T47-D breast cancer cells. J Steroid Biochem Mol Biol. 2009;114:200-6 pubmed publisher
    ..In conclusion, our findings strongly support suitability of non-steroidal 17betaHSD1-inhibitors for the treatment of estrogen dependent diseases. ..
  47. Järvensivu P, Heinosalo T, Hakkarainen J, Kronqvist P, Saarinen N, Poutanen M. HSD17B1 expression induces inflammation-aided rupture of mammary gland myoepithelium. Endocr Relat Cancer. 2018;25:393-406 pubmed publisher
    Hydroxysteroid (17-beta) dehydrogenase type 1 (HSD17B1) converts low-active estrogen estrone to highly active estradiol...
  48. Feigelson H, Cox D, Cann H, Wacholder S, Kaaks R, Henderson B, et al. Haplotype analysis of the HSD17B1 gene and risk of breast cancer: a comprehensive approach to multicenter analyses of prospective cohort studies. Cancer Res. 2006;66:2468-75 pubmed
    The 17beta-hydroxysteroid dehydrogenase 1 gene (HSD17B1) encodes 17HSD1, which catalyzes the final step of estradiol biosynthesis...
  49. Plourde M, Samson C, Durocher F, Sinilnokova O, Simard J. Characterization of HSD17B1 sequence variants in breast cancer cases from French Canadian families with high risk of breast and ovarian cancer. J Steroid Biochem Mol Biol. 2008;109:115-28 pubmed
    A family history of disease and estrogen exposure are risk factors for breast cancer. The HSD17B1 gene encodes a key steroidogenic enzyme that catalyses the final step of estradiol biosynthesis, rendering it a good candidate gene for ..
  50. Hamaguchi M, Nishio M, Toyama T, Sugiura H, Kondo N, Fujii Y, et al. Possible difference in frequencies of genetic polymorphisms of estrogen receptor alpha, estrogen metabolism and P53 genes between estrogen receptor-positive and -negative breast cancers. Jpn J Clin Oncol. 2008;38:734-42 pubmed publisher
    ..We compared genetic polymorphisms of ERalpha, estrogen metabolism genes (CYP17A1, CYP19A1, HSD17B1 COASY, CYP1B1 and COMT), and p53 between ER-positive and -negative female Japanese breast cancer patients, and ..
  51. Sowers M, Randolph J, Zheng H, Jannausch M, McConnell D, Kardia S, et al. Genetic polymorphisms and obesity influence estradiol decline during the menopause. Clin Endocrinol (Oxf). 2011;74:618-23 pubmed publisher
    ..The rate of the E2 decline and the subsequent postmenopausal E2 levels may be relevant to oestrogen-sensitive chronic diseases including cancers. ..
  52. You X, Yang R, Tang X, Gao L, Ni X. Corticotropin-releasing hormone stimulates estrogen biosynthesis in cultured human placental trophoblasts. Biol Reprod. 2006;74:1067-72 pubmed
    ..with this thesis, CRH increased whereas alpha-helical CRH decreased the mRNA levels of STS, CYP19A1, and HSD17B1, the key enzymes for estrogen synthesis...
  53. Figueroa J, Sakoda L, Graubard B, Chanock S, Rubertone M, Erickson R, et al. Genetic variation in hormone metabolizing genes and risk of testicular germ cell tumors. Cancer Causes Control. 2008;19:917-29 pubmed publisher
    ..33 single nucleotide polymorphisms (SNPs) in four hormone metabolism candidate genes (CYP1A1, CYP17A1, HSD17B1, HSD17B4) and the androgen receptor gene (AR) were genotyped...
  54. VELISKOVA J, VELISEK L. Gonadal status-dependent effects of in vivo ?-estradiol administration to female rats on in vitro epileptiform activity induced by low [Mg2+]? in combined hippocampus-entorhinal cortex slices. Epilepsy Res. 2013;107:297-301 pubmed publisher
    ..Our data suggest that EB in physiologically relevant concentrations does not seem to negatively affect hippocampal neuronal excitability, nevertheless supraphysiological EB levels may enhance seizure severity. ..
  55. Sen N, Liu X, Craig Z. Short term exposure to di-n-butyl phthalate (DBP) disrupts ovarian function in young CD-1 mice. Reprod Toxicol. 2015;53:15-22 pubmed publisher
    ..Interestingly, mRNAs encoding the steroidogenic enzymes Hsd17b1, Cyp17a1 and Cyp19a1 were increased in all DBP-treated groups...
  56. Yang J, Hu S, Rao M, Hu L, Lei H, Wu Y, et al. Copper nanoparticle-induced ovarian injury, follicular atresia, apoptosis, and gene expression alterations in female rats. Int J Nanomedicine. 2017;12:5959-5971 pubmed publisher
    ..Of these, 180 and 141 genes were upregulated and downregulated, respectively. Hsd17b1, Hsd3b1, Hsd3b6, and Hsd3b were involved in steroid and hormone metabolism, whereas ..
  57. Järvensivu P, Saloniemi Heinonen T, Awosanya M, Koskimies P, Saarinen N, Poutanen M. HSD17B1 expression enhances estrogen signaling stimulated by the low active estrone, evidenced by an estrogen responsive element-driven reporter gene in vivo. Chem Biol Interact. 2015;234:126-34 pubmed publisher
    Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) belongs to a family of short-chain-dehydrogenases...
  58. Jia X, Liu Z, Lu X, Tang J, Wu Y, Du Q, et al. Effects of MCLR exposure on sex hormone synthesis and reproduction-related genes expression of testis in male Rana nigromaculata. Environ Pollut. 2018;236:12-20 pubmed publisher
    ..The mRNA levels of HSD17B3 were downregulated, and HSD17B1 and CYP19A1 mRNA expression levels were upregulated, respectively...
  59. Bacallao K, Leon L, Gabler F, Soto E, Romero C, Valladares L, et al. In situ estrogen metabolism in proliferative endometria from untreated women with polycystic ovarian syndrome with and without endometrial hyperplasia. J Steroid Biochem Mol Biol. 2008;110:163-9 pubmed publisher
    ..05). These results indicate that the activity of enzymes related to the steroid metabolism in analyzed PCOSE differ from those found in the CE. Consequently, PCOSE may present an in situ deregulation of the steroid metabolism...
  60. Strugała A, Jagodziński P. Conversion of estrone to 17 beta-estradiol in Jurkat acute T cell leukemia Hut-78 T- and Raji B lymphoma cell lines in vitro. Biomed Pharmacother. 2013;67:299-303 pubmed publisher
    ..Therefore, we studied the levels of 17 beta-hydroxysteroid-dehydrogenase type 1 (HSD17B1) transcript and protein and the production of 17 beta-estradiol (E2) from estrone (E1) in human Jurkat acute T ..
  61. Cornel K, Krakstad C, Delvoux B, Xanthoulea S, Jori B, Bongers M, et al. High mRNA levels of 17?-hydroxysteroid dehydrogenase type 1 correlate with poor prognosis in endometrial cancer. Mol Cell Endocrinol. 2017;442:51-57 pubmed publisher
    ..the intracrine estrogen generation in EC: (a) the balance between 17?-hydroxysteroid-dehydrogenase-type 1 (HSD17B1), that generates active estrogens, and HSD17B2, converting active into poorly active compounds; (b) the balance ..
  62. Silva S, Cabral M, Bezerra de Castro G, Pires M, Azevedo A, Manita I, et al. Breast cancer risk and polymorphisms in genes involved in metabolism of estrogens (CYP17, HSD17beta1, COMT and MnSOD): possible protective role of MnSOD gene polymorphism Val/Ala and Ala/Ala in women that never breast fed. Oncol Rep. 2006;16:781-8 pubmed
    ..575 (0.327-1.011). These data seem to suggest that individuals who never breast fed with MnSOD Val16Ala variant allele are at a lower risk for breast cancer, but larger studies are required to confirm these results. ..
  63. Zhang C, Wang W, Chen J, Lin S. Reductive 17beta-hydroxysteroid dehydrogenases which synthesize estradiol and inactivate dihydrotestosterone constitute major and concerted players in ER+ breast cancer cells. J Steroid Biochem Mol Biol. 2015;150:24-34 pubmed publisher
    ..17β-HSD1 and -7 are principal reductive 17β-HSDs and major players in the viability of estrogen-dependent breast cancer cells. Combined targeting of these enzymes may be potential for molecular therapy of such cancer. ..
  64. Santillo A, Falvo S, Di Fiore M, Chieffi Baccari G. Seasonal changes and sexual dimorphism in gene expression of StAR protein, steroidogenic enzymes and sex hormone receptors in the frog brain. Gen Comp Endocrinol. 2017;246:226-232 pubmed publisher
    ..Seasonal fluctuations in expression levels of hsd3b1, hsd17b1, srd5a1 and cyp19a1 genes for neurosteroidogenic enzymes occurred in D-M region of both sexes, with the higher ..
  65. Osiński M, Mostowska A, Wirstlein P, Skrzypczak J, Jagodziński P, Szczepanska M. Involvement of 17?-hydroxysteroid dehydrogenase type gene 1 937 A>G polymorphism in infertility in Polish Caucasian women with endometriosis. J Assist Reprod Genet. 2017;34:789-794 pubmed publisher
    ..The 17?-hydroxysteroid dehydrogenase 1 (HSD17B1) converts estrone to 17? estradiol...
  66. Hilborn E, Stal O, Alexeyenko A, Jansson A. The regulation of hydroxysteroid 17?-dehydrogenase type 1 and 2 gene expression in breast cancer cell lines by estradiol, dihydrotestosterone, microRNAs, and genes related to breast cancer. Oncotarget. 2017;8:62183-62194 pubmed publisher
    To investigate the influence of estrogen, androgen, microRNAs, and genes implicated in breast cancer on the expression of HSD17B1 and HSD17B2.
  67. Winqvist R, Peltoketo H, Isomaa V, Grzeschik K, Mannermaa A, Vihko R. The gene for 17 beta-hydroxysteroid dehydrogenase maps to human chromosome 17, bands q12-q21, and shows an RFLP with ScaI. Hum Genet. 1990;85:473-6 pubmed
    ..04 (A1) and 0.96 (A2). ..
  68. Baker M. Human placental 17 beta-hydroxysteroid dehydrogenase is homologous to NodG protein of Rhizobium meliloti. Mol Endocrinol. 1989;3:881-4 pubmed
    ..We propose that the steroid recognition site on 17 beta-OH-steroid dehydrogenase evolved from an ancestral recognition site for polyols such as ribitol and glucitol-6-phosphate. ..
  69. Iwasaki M, Hamada G, Nishimoto I, Netto M, Motola J, Laginha F, et al. Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians. Nutr Cancer. 2010;62:466-75 pubmed publisher
    ..77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk. ..
  70. Drzewiecka H, Gałęcki B, Jarmołowska Jurczyszyn D, Kluk A, Dyszkiewicz W, Jagodziński P. Increased expression of 17-beta-hydroxysteroid dehydrogenase type 1 in non-small cell lung cancer. Lung Cancer. 2015;87:107-16 pubmed publisher
    ..The 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1) catalyzes the reduction of estrone (E1) to the highly potent E2...
  71. Schörghofer D, Kinslechner K, Preitschopf A, Schütz B, Röhrl C, Hengstschläger M, et al. The HDL receptor SR-BI is associated with human prostate cancer progression and plays a possible role in establishing androgen independence. Reprod Biol Endocrinol. 2015;13:88 pubmed publisher
    ..02) in patients expressing high intra-tumor levels of SR-BI. SR-BI mRNA correlated with HSD17B1 and HSD3B1 and SR-BI protein staining showed correlation with active ribosomal protein S6 (RS = 0...
  72. Justenhoven C, Hamann U, Schubert F, Zapatka M, Pierl C, Rabstein S, et al. Breast cancer: a candidate gene approach across the estrogen metabolic pathway. Breast Cancer Res Treat. 2008;108:137-49 pubmed
    ..Of these CYP17A1, CYP19A1, EPHX1, HSD17B1, SRD5A2, and PPARG2 participate in biosynthesis, CYP1A1, CYP1B1, COMT, GSTP1, and SOD2 in catabolism and ..
  73. Kato I, Cichon M, Yee C, Land S, Korczak J. African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer. Cancer Epidemiol. 2009;33:24-30 pubmed publisher
    ..CYP1B1 432 Val allele was significantly more often found in the cases than in the controls overall and the HSD17B1 312 Gly allele was specifically associated with premenopausal breast cancer risk (OR=3.00, 95%CI 1.29-6.99)...
  74. Peltoketo H, Isomaa V, Vihko R. Genomic organization and DNA sequences of human 17 beta-hydroxysteroid dehydrogenase genes and flanking regions. Localization of multiple Alu sequences and putative cis-acting elements. Eur J Biochem. 1992;209:459-66 pubmed
    ..These putative sequences included estrogen and progesterone/glucocorticoid-response elements and a cyclic-AMP regulatory element. ..
  75. Burns D, Engel L, Bethune J. Amino acid composition and subunit structure. Human placental 17 -estradiol dehydrogenase. Biochemistry. 1972;11:2699-703 pubmed
  76. Chia V, Li Y, Quraishi S, Graubard B, Figueroa J, Weber J, et al. Effect modification of endocrine disruptors and testicular germ cell tumour risk by hormone-metabolizing genes. Int J Androl. 2010;33:588-96 pubmed publisher
    ..polychlorinated biphenyls (PCBs), modified by polymorphisms in five hormone-metabolizing genes (CYP17A1, CYP1A1, HSD17B1, HSD17B4 and AR)...
  77. Mazumdar M, Fournier D, Zhu D, Cadot C, Poirier D, Lin S. Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy. Biochem J. 2009;424:357-66 pubmed publisher
    ..Such inhibitors that block oestrogen synthesis to suppress the sulfatase pathway producing oestradiol can be used in adjuvant therapies with oestrogen receptor blockade, opening a new orientation of breast cancer treatment. ..
  78. Rawłuszko A, Horbacka K, Krokowicz P, Jagodziński P. Decreased expression of 17?-hydroxysteroid dehydrogenase type 1 is associated with DNA hypermethylation in colorectal cancer located in the proximal colon. BMC Cancer. 2011;11:522 pubmed publisher
    ..sulfatase pathway from estrone (E1) sulfate followed by E1 reduction to E2 by 17-?-hydroxysteroid dehydrogenase (HSD17B1), so HSD17B1 gene expression may play an important role in the production of E2 in peripheral tissue, including ..
  79. Han Q, Campbell R, Gangloff A, Huang Y, Lin S. Dehydroepiandrosterone and dihydrotestosterone recognition by human estrogenic 17beta-hydroxysteroid dehydrogenase. C-18/c-19 steroid discrimination and enzyme-induced strain. J Biol Chem. 2000;275:1105-11 pubmed
    ..The electron density of DHEA also revealed a distortion of its 17-ketone toward a beta-oriented form, which approaches the transition-state conformation for DHEA reduction. ..
  80. Sakoda L, Blackston C, Doherty J, Ray R, Lin M, Stalsberg H, et al. Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women. Cancer Epidemiol Biomarkers Prev. 2008;17:1066-73 pubmed publisher
    ..women, we examined genotypes of the CYP11A1 pentanucleotide [(TAAAA)n] repeat (D15S520), CYP17A1 rs743572, and HSD17B1 rs605059 polymorphisms in relation to the risk of breast cancer and fibrocystic breast conditions, comparing 615 ..
  81. Gaudet M, Chanock S, Dunning A, Driver K, Brinton L, Lissowska J, et al. HSD17B1 genetic variants and hormone receptor-defined breast cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2766-72 pubmed publisher
    b>HSD17B1 is an important candidate gene in breast cancer via its role in converting estrone to estradiol...
  82. Lamp M, Peters M, Reinmaa E, Haller Kikkatalo K, Kaart T, Kadastik U, et al. Polymorphisms in ESR1, ESR2 and HSD17B1 genes are associated with fertility status in endometriosis. Gynecol Endocrinol. 2011;27:425-33 pubmed publisher
    ..receptor gene PGR (rs10895068 - G/A SNP, 306-bp Alu-insertion), 17?-hydroxysteroid dehydrogenase type 1 gene HSD17B1 (rs605059 - A/G SNP), and aromatase gene CYP19A1 (rs10046 - C/T SNP, (TTTA)(n) tetranucleotide repeat, 3-bp TCT ..
  83. Rawłuszko A, Krokowicz P, Jagodziński P. Butyrate induces expression of 17?-hydroxysteroid dehydrogenase type 1 in HT29 and SW707 colorectal cancer cells. DNA Cell Biol. 2011;30:661-9 pubmed publisher
    ..In peripheral tissue, E2 can be produced locally by 17?-hydroxysteroid dehydrogenase 1 (HSD17B1) estrone (E1) reduction...
  84. Hu X, Zhou Y, Feng Q, Wang R, Su L, Long J, et al. Association of endometriosis risk and genetic polymorphisms involving biosynthesis of sex steroids and their receptors: an updating meta-analysis. Eur J Obstet Gynecol Reprod Biol. 2012;164:1-9 pubmed publisher
    ..estrogen receptor gene (ER), progesterone receptor gene (PR), 17-beta-hydroxysteroid dehydrogenase type 1 gene (HSD17B1), and cytochrome P450 subfamily 19 (CYP19) polymorphisms with endometriosis risk were identified...
  85. Aka J, Zerradi M, Houle F, Huot J, Lin S. 17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration. Breast Cancer Res. 2012;14:R92 pubmed
    ..The novel findings in this study suggest several directions for future research on the contribution of 17?-HSD1 to breast cancer progression and related treatment. ..
  86. Santos D, Coelho T, Alves Ferreira M, Sequeiros J, Mendonça D, Alonso I, et al. Variants in RBP4 and AR genes modulate age at onset in familial amyloid polyneuropathy (FAP ATTRV30M). Eur J Hum Genet. 2016;24:756-60 pubmed publisher
    ..of APCS and RBP4 genes and to study for the first time the involvement of sex-linked genetic modifiers - AR and HSD17B1 genes - in AO variation in Portuguese families...
  87. de Souza D, Salles L, Camargo R, Gulart L, Costa E Silva S, de Lima B, et al. Effects of PI3K and FSH on steroidogenesis, viability and embryo development of the cumulus-oocyte complex after in vitro culture. Zygote. 2018;26:50-61 pubmed publisher
    ..those that did not, and real-time polymerase chain reaction (PCR) for BAX, BCL2, LHR, FSHR, CYP11A1, CYP19A1 and HSD17B1 genes was performed...
  88. Gunnarsson C, Ahnström M, Kirschner K, Olsson B, Nordenskjold B, Rutqvist L, et al. Amplification of HSD17B1 and ERBB2 in primary breast cancer. Oncogene. 2003;22:34-40 pubmed
    ..The gene coding for 17beta-HSD type 1 (HSD17B1) is located at 17q12-21, close to the more studied ERBB2 and BRCA1...
  89. Betz G. Reaction mechanism of 17-beta-estradiol dehydrogenase determined by equilibrium rate exchange. J Biol Chem. 1971;246:2063-8 pubmed
  90. Zhang Y, Word R, Fesmire S, Carr B, Rainey W. Human ovarian expression of 17 beta-hydroxysteroid dehydrogenase types 1, 2, and 3. J Clin Endocrinol Metab. 1996;81:3594-8 pubmed
    Three isozymes of 17 beta-hydroxysteroid dehydrogenase (17 beta HSD) have been cloned and characterized as distinct gene products (17 beta HSD1, 17 beta HSD2, and 17 beta HSD3)...
  91. Tremblay Y, Ringler G, Morel Y, Mohandas T, Labrie F, Strauss J, et al. Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen----q25. J Biol Chem. 1989;264:20458-62 pubmed
    ..By contrast, cAMP decreases estrogenic 17KSR mRNA in primary cultures of human cytotrophoblasts and human granulosa cells, a pattern of tropic regulation that differs from other steroidogenic enzyme mRNAs. ..
  92. Qiu W, Campbell R, Gangloff A, Dupuis P, Boivin R, Tremblay M, et al. A concerted, rational design of type 1 17beta-hydroxysteroid dehydrogenase inhibitors: estradiol-adenosine hybrids with high affinity. FASEB J. 2002;16:1829-31 pubmed
    ..These results confirm our initial strategy of combining studies of structural biology and enzyme mechanism in the inhibitor design, which may be applied to other steroidogenic enzymes involved in human diseases. ..