- Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeuticsCharles R Kissinger
Pfizer La Jolla, 10777 Science Center Dr, San Diego, CA 92121, USA
J Mol Biol 342:943-52. 2004..The crystal structure provides a basis for the design of potent, highly specific ABAD/HSD10 inhibitors with potential application in the treatment of Alzheimer's disease...
- Isolation and characterization of novel human short-chain dehydrogenase/reductase SCDR10B which is highly expressed in the brain and acts as hydroxysteroid dehydrogenaseChaoqun Huang
State Key Laboratory of Genetic Engineering, The Institute of Genetics, Fudan University, Shanghai, People s Republic of China
Acta Biochim Pol 56:279-89. 2009..We report here the cloning and characterization of a novel human SDR gene SCDR10B which encodes a protein with similarity to 11beta-hydroxysteroid dehydrogenase 1...