Gene Symbol: HSD11B1
Description: hydroxysteroid 11-beta dehydrogenase 1
Alias: 11-DH, 11-beta-HSD1, CORTRD2, HDL, HSD11, HSD11B, HSD11L, SDR26C1, corticosteroid 11-beta-dehydrogenase isozyme 1, short chain dehydrogenase/reductase family 26C member 1
Species: human
Products:     HSD11B1

Top Publications

  1. Tomlinson J, Walker E, Bujalska I, Draper N, Lavery G, Cooper M, et al. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev. 2004;25:831-66 pubmed
    ..quot;11beta-HSD1 knockout state" in humans, has been defined and is caused by intronic mutations in HSD11B1 that decrease gene transcription together with mutations in hexose-6-phosphate dehydrogenase, an endoluminal ..
  2. Franks P, Knowler W, Nair S, Koska J, Lee Y, Lindsay R, et al. Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians. Hypertension. 2004;44:681-8 pubmed
    ..These data demonstrate association between genetic variability at 11betaHSD1 with hypertension, but these effects are modified by environmental factors. ..
  3. Nair S, Lee Y, Lindsay R, Walker B, Tataranni P, Bogardus C, et al. 11beta-Hydroxysteroid dehydrogenase Type 1: genetic polymorphisms are associated with Type 2 diabetes in Pima Indians independently of obesity and expression in adipocyte and muscle. Diabetologia. 2004;47:1088-95 pubmed
    ..Single nucleotide polymorphisms in the HSD11B1 gene were genotyped in a larger group of full-blooded Pima Indians...
  4. Ignatova I, Kostadinova R, Goldring C, Nawrocki A, Frey F, Frey B. Tumor necrosis factor-alpha upregulates 11beta-hydroxysteroid dehydrogenase type 1 expression by CCAAT/enhancer binding protein-beta in HepG2 cells. Am J Physiol Endocrinol Metab. 2009;296:E367-77 pubmed publisher
    ..mechanism of this increase, we investigated basal and TNF-alpha-induced transcription of the 11beta-HSD1 gene (HSD11B1) in HepG2 cells. We found that TNF-alpha acts via p38 MAPK pathway...
  5. Veilleux A, Rheaume C, Daris M, Luu The V, Tchernof A. Omental adipose tissue type 1 11 beta-hydroxysteroid dehydrogenase oxoreductase activity, body fat distribution, and metabolic alterations in women. J Clin Endocrinol Metab. 2009;94:3550-7 pubmed publisher
    ..05). These results suggest that a relatively higher 11 beta-HSD1 activity in OM vs. sc adipose tissue is associated with preferential visceral fat accumulation and concomitant metabolic alterations. ..
  6. Robitaille J, Brouillette C, Houde A, Despres J, Tchernof A, Vohl M. Molecular screening of the 11beta-HSD1 gene in men characterized by the metabolic syndrome. Obes Res. 2004;12:1570-5 pubmed
    ..In conclusion, molecular screening of the 11beta-HSD1 gene did not reveal any sequence variations that can significantly contribute to the etiology of the metabolic syndrome among French-Canadians. ..
  7. Sutinen J, Kannisto K, Korsheninnikova E, Nyman T, Ehrenborg E, Andrew R, et al. In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue. Diabetologia. 2004;47:1668-71 pubmed
    ..We suggest that increased adipose tissue 11beta-HSD1 may explain the pseudo-Cushing's features in patients with HAART-associated lipodystrophy, and is a potential therapeutic target. ..
  8. Gambineri A, Vicennati V, Genghini S, Tomassoni F, Pagotto U, Pasquali R, et al. Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2006;91:2295-302 pubmed
    ..Our objective was to investigate a functional polymorphism in HSD11B1 (T-->G in the third intron rs12086634, which associates with lower 11beta-HSD1 activity) in PCOS with and ..
  9. Walker E, Ahmed A, Lavery G, Tomlinson J, Kim S, Cooper M, et al. 11beta-Hydroxysteroid Dehydrogenase Type 1 Regulation by Intracellular Glucose 6-Phosphate Provides Evidence for a Novel Link between Glucose Metabolism and Hypothalamo-Pituitary-Adrenal Axis Function. J Biol Chem. 2007;282:27030-6 pubmed
    ..The cellular trafficking of G6P therefore directly regulates 11beta-HSD1 reductase activity and provides a novel link between glucose metabolism and function of the hypothalamo-pituitary-adrenal axis. ..

More Information


  1. Gelernter Yaniv L, Feng N, Sebring N, Hochberg Z, Yanovski J. Associations between a polymorphism in the 11 beta hydroxysteroid dehydrogenase type I gene and body composition. Int J Obes Relat Metab Disord. 2003;27:983-6 pubmed
    ..11betaHSD-1 may be one of the genes relevant for pediatric-onset obesity and its complications. ..
  2. Lindsay R, Wake D, Nair S, Bunt J, Livingstone D, Permana P, et al. Subcutaneous adipose 11 beta-hydroxysteroid dehydrogenase type 1 activity and messenger ribonucleic acid levels are associated with adiposity and insulinemia in Pima Indians and Caucasians. J Clin Endocrinol Metab. 2003;88:2738-44 pubmed
    ..Our data support the hypothesis that increased regeneration of cortisol in adipose tissue influences metabolic sequelae of human obesity. ..
  3. Michailidou Z, Jensen M, Dumesic D, Chapman K, Seckl J, Walker B, et al. Omental 11beta-hydroxysteroid dehydrogenase 1 correlates with fat cell size independently of obesity. Obesity (Silver Spring). 2007;15:1155-63 pubmed
    ..The novel correlation of 11betaHSD1 with omental fat cell size, independent of obesity, suggests that intracellular cortisol regeneration is a strong predictor of hypertrophy in the omentum. ..
  4. Bujalska I, Quinkler M, Tomlinson J, Montague C, Smith D, Stewart P. Expression profiling of 11beta-hydroxysteroid dehydrogenase type-1 and glucocorticoid-target genes in subcutaneous and omental human preadipocytes. J Mol Endocrinol. 2006;37:327-40 pubmed
    ..The Affymetrix data have been confirmed by quantitative real-time PCR for ten specific genes, including HSD11B1, GR, C/EBPalpha, C/EBPbeta, IL-6, FABP4, APOD, IRS2, AGTR1 and GHR...
  5. Paulsen S, Pedersen S, Jørgensen J, Fisker S, Christiansen J, Flyvbjerg A, et al. Growth hormone (GH) substitution in GH-deficient patients inhibits 11beta-hydroxysteroid dehydrogenase type 1 messenger ribonucleic acid expression in adipose tissue. J Clin Endocrinol Metab. 2006;91:1093-8 pubmed
    ..798; P < 0.0001). GH treatment is able to decrease 11beta-HSD1 mRNA and increase 11beta-HSD2 and accordingly may be able to reduce the amount of locally produced cortisol in adipose tissue. ..
  6. Lee M, Fried S, Mundt S, Wang Y, Sullivan S, Stefanni A, et al. Depot-specific regulation of the conversion of cortisone to cortisol in human adipose tissue. Obesity (Silver Spring). 2008;16:1178-85 pubmed publisher
    ..We conclude that in the presence of insulin, glucocorticoids cause a depot-specific increase in the activation of cortisone within Om adipose tissue, and that this mechanism may contribute to adipocyte hypertrophy and visceral obesity. ..
  7. Andrew R, Westerbacka J, Wahren J, Yki Jarvinen H, Walker B. The contribution of visceral adipose tissue to splanchnic cortisol production in healthy humans. Diabetes. 2005;54:1364-70 pubmed
    ..Thus, in addition to free fatty acids and adipokines, the portal vein delivers cortisol to the liver, and inhibition of 11HSD1 in visceral adipose tissue may indeed be valuable in ameliorating insulin resistance in obesity. ..
  8. Desbriere R, Vuaroqueaux V, Achard V, Boullu Ciocca S, Labuhn M, Dutour A, et al. 11beta-hydroxysteroid dehydrogenase type 1 mRNA is increased in both visceral and subcutaneous adipose tissue of obese patients. Obesity (Silver Spring). 2006;14:794-8 pubmed
    ..They strengthen the importance of 11beta-HSD-1 in human obesity and its associated complications and suggest the need of clinical studies with specific 11beta-HSD-1 inhibitors. ..
  9. San Millan J, Botella Carretero J, Alvarez Blasco F, Luque Ramírez M, Sancho J, Moghetti P, et al. A study of the hexose-6-phosphate dehydrogenase gene R453Q and 11beta-hydroxysteroid dehydrogenase type 1 gene 83557insA polymorphisms in the polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90:4157-62 pubmed
    ..dehydrogenase gene (H6PD) and 83557insA mutations in 11beta-hydroxysteroid dehydrogenase (11betaHSD) type 1 gene (HSD11B1) interact, resulting in cortisone reductase deficiency (CRD), a rare disorder characterized by a polycystic ovary ..
  10. Malavasi E, Kelly V, Nath N, Gambineri A, Dakin R, Pagotto U, et al. Functional effects of polymorphisms in the human gene encoding 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1): a sequence variant at the translation start of 11 beta-HSD1 alters enzyme levels. Endocrinology. 2010;151:195-202 pubmed publisher
    ..Polymorphisms in HSD11B1, the gene encoding 11 beta-HSD1, have been associated with metabolic phenotype in humans, including type 2 ..
  11. Staab C, Stegk J, Haenisch S, Neiss E, Köbsch K, Ebert B, et al. Analysis of alternative promoter usage in expression of HSD11B1 including the development of a transcript-specific quantitative real-time PCR method. Chem Biol Interact. 2011;191:104-12 pubmed publisher
    Overexpression of the microsomal enzyme 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1, human gene HSD11B1 or SDR26C1) associates with the metabolic syndrome as well as some inflammatory diseases...
  12. Atalar F, Vural B, Ciftci C, Demirkan A, Akan G, Susleyici Duman B, et al. 11?-hydroxysteroid dehydrogenase type 1 gene expression is increased in ascending aorta tissue of metabolic syndrome patients with coronary artery disease. Genet Mol Res. 2012;11:3122-32 pubmed
    ..tissue and body mass index, while a negative correlation was found between 11?-HSD-1 expression in EA tissue and HDL. Expression of CD68, a macrophage marker, was significantly increased in both tissues of the metabolic syndrome ..
  13. Bujalska I, Walker E, Tomlinson J, Hewison M, Stewart P. 11Beta-hydroxysteroid dehydrogenase type 1 in differentiating omental human preadipocytes: from de-activation to generation of cortisol. Endocr Res. 2002;28:449-61 pubmed
    ..The differences in set-point of 11beta-HSD1 activity between OM and SC human adipose tissue may be an important factor in the pathogenesis of visceral obesity. ..
  14. Tiganescu A, Tahrani A, Morgan S, Otranto M, Desmouliere A, Abrahams L, et al. 11?-Hydroxysteroid dehydrogenase blockade prevents age-induced skin structure and function defects. J Clin Invest. 2013;123:3051-60 pubmed publisher
  15. Mariniello B, Ronconi V, Rilli S, Bernante P, Boscaro M, Mantero F, et al. Adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in obesity and Cushing's syndrome. Eur J Endocrinol. 2006;155:435-41 pubmed
    ..The lack of increase of 11beta-HSD1 expression in Cushing's syndrome could suggest downregulation of the enzyme as a result of long-term overstimulation. ..
  16. Baudrand R, Carvajal C, Riquelme A, Morales M, Solis N, Pizarro M, et al. Overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in hepatic and visceral adipose tissue is associated with metabolic disorders in morbidly obese patients. Obes Surg. 2010;20:77-83 pubmed publisher
    ..The observed correlations between hepatic and VAT 11beta-HSD1 expression with dyslipidemia and insulin resistance suggest that this enzyme might have a pathogenic role in obesity and related metabolic disorders. ..
  17. Tomlinson J, Finney J, Gay C, Hughes B, Hughes S, Stewart P. Impaired glucose tolerance and insulin resistance are associated with increased adipose 11beta-hydroxysteroid dehydrogenase type 1 expression and elevated hepatic 5alpha-reductase activity. Diabetes. 2008;57:2652-60 pubmed publisher
    ..Enhanced 5alphaR activity in both sexes is associated with insulin resistance but not body composition. Augmented glucocorticoid inactivation may serve as a compensatory, protective mechanism to preserve insulin sensitivity. ..
  18. Yang Z, Zhu X, Guo C, Sun K. Stimulation of 11?-HSD1 expression by IL-1? via a C/EBP binding site in human fetal lung fibroblasts. Endocrine. 2009;36:404-11 pubmed publisher
  19. Gambineri A, Tomassoni F, Munarini A, Stimson R, Mioni R, Pagotto U, et al. A combination of polymorphisms in HSD11B1 associates with in vivo 11{beta}-HSD1 activity and metabolic syndrome in women with and without polycystic ovary syndrome. Eur J Endocrinol. 2011;165:283-92 pubmed publisher
    ..single nucleotide polymorphisms (SNPs) in HSD11B1, the gene encoding 11?-HSD1, have been associated with type 2 diabetes and hypertension in population-based ..
  20. Jang C, Obeyesekere V, Dilley R, Krozowski Z, Inder W, Alford F. Altered activity of 11beta-hydroxysteroid dehydrogenase types 1 and 2 in skeletal muscle confers metabolic protection in subjects with type 2 diabetes. J Clin Endocrinol Metab. 2007;92:3314-20 pubmed
    ..463; P = 0.026). The activities of skeletal muscle 11beta-HSD1 and 11beta-HSD2 are altered in diabetes, which together may reduce intracellular cortisol generation, potentially conferring metabolic protection. ..
  21. Smit P, Dekker M, de Jong F, van den Beld A, Koper J, Pols H, et al. Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia. J Clin Endocrinol Metab. 2007;92:359-62 pubmed
    ..was proposed that a combination of the 83,557insA polymorphism in the 11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1) gene and the R453Q polymorphism in the hexose-6-phosphate dehydrogenase (H6PD) gene interacts to cause cortisone ..
  22. Draper N, Walker E, Bujalska I, Tomlinson J, Chalder S, Arlt W, et al. Mutations in the genes encoding 11beta-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase interact to cause cortisone reductase deficiency. Nat Genet. 2003;34:434-9 pubmed
    ..1,2). This suggests a defect in the gene HSD11B1 encoding 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), a primary regulator of tissue-specific ..
  23. Engeli S, Böhnke J, Feldpausch M, Gorzelniak K, Heintze U, Janke J, et al. Regulation of 11beta-HSD genes in human adipose tissue: influence of central obesity and weight loss. Obes Res. 2004;12:9-17 pubmed
  24. Eijken M, Hewison M, Cooper M, de Jong F, Chiba H, Stewart P, et al. 11beta-Hydroxysteroid dehydrogenase expression and glucocorticoid synthesis are directed by a molecular switch during osteoblast differentiation. Mol Endocrinol. 2005;19:621-31 pubmed
    ..This efficient mechanism by which osteoblasts generate cortisol in an autocrine fashion to ensure proper differentiation will help to understand the complex effects of cortisol on bone metabolism. ..
  25. Dujic T, Bego T, Mlinar B, Semiz S, Malenica M, Prnjavorac B, et al. Association between 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population. Biochem Med (Zagreb). 2012;22:76-85 pubmed
    ..In this study, we investigated the association of two 11beta-HSD1 gene (HSD11B1) polymorphisms with the metabolic syndrome (MetS) and its characteristics in the Bosnian population...
  26. Wake D, Rask E, Livingstone D, Soderberg S, Olsson T, Walker B. Local and systemic impact of transcriptional up-regulation of 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue in human obesity. J Clin Endocrinol Metab. 2003;88:3983-8 pubmed
    ..Although this may drive a compensatory increase in leptin synthesis, whether it has an adverse effect on intraadipose cortisol concentrations and GR-dependent gene regulation remains to be established. ..
  27. Andres J, Mai K, Mohlig M, Weickert M, Bumke Vogt C, Diederich S, et al. Cell-type specific regulation of the human 11beta-hydroxysteroid dehydrogenase type 1 promoter. Arch Physiol Biochem. 2007;113:110-5 pubmed
    ..The described promoter constructs will allow subsequent studies about the role of specific hormonal, metabolic and transcription factors to finally characterise the regulation of the human 11beta-HSD1-promoter in more detail. ..
  28. Paulsen S, Nielsen M, Richelsen B, Bruun J, Flyvbjerg A, Pedersen S. Upregulation of adipose 11-beta-hydroxysteroid dehydrogenase type 1 expression in ovariectomized rats is due to obesity rather than lack of estrogen. Obesity (Silver Spring). 2008;16:731-5 pubmed publisher
    ..In the in vitro studies, no direct effect of estrogen on adipose 11beta-HSD1 was found. The upregulation of 11beta-HSD1 in ovariectomized rats was most likely due to changes in body composition rather than lack of estrogen. ..
  29. Mlinar B, Marc J, Jensterle M, Bokal E, Jerin A, Pfeifer M. Expression of 11?-hydroxysteroid dehydrogenase type 1 in visceral and subcutaneous adipose tissues of patients with polycystic ovary syndrome is associated with adiposity. J Steroid Biochem Mol Biol. 2011;123:127-32 pubmed publisher
    ..b>HSD11B1 gene expression and expression of lipid metabolism genes were measured in subcutaneous and visceral adipose ..
  30. White P, Mune T, Agarwal A. 11 beta-Hydroxysteroid dehydrogenase and the syndrome of apparent mineralocorticoid excess. Endocr Rev. 1997;18:135-56 pubmed
    ..This gene represents a candidate locus for the common, "essential" form of hypertension. ..
  31. Tomlinson J, Moore J, Clark P, Holder G, Shakespeare L, Stewart P. Weight loss increases 11beta-hydroxysteroid dehydrogenase type 1 expression in human adipose tissue. J Clin Endocrinol Metab. 2004;89:2711-6 pubmed
    ..Inhibition of 11betaHSD1 may therefore be a novel, therapeutic strategy for insulin sensitization. ..
  32. Ku Y, Koo B, Kwak S, Cho Y, Shin H, Lee H, et al. Regulatory effect of common promoter polymorphisms on the expression of the 11beta-hydroxysteroid dehydrogenase type 1 gene. Horm Res. 2009;72:25-32 pubmed publisher
    ..11beta-hydroxysteroid dehydrogenase type 1 (HSD11B1), which converts inactive cortisone to active cortisol, has become an emerging therapeutic target for type 2 ..
  33. White P. Genotypes at 11beta-hydroxysteroid dehydrogenase type 11B1 and hexose-6-phosphate dehydrogenase loci are not risk factors for apparent cortisone reductase deficiency in a large population-based sample. J Clin Endocrinol Metab. 2005;90:5880-3 pubmed
    ..These findings suggest a deficiency of 11beta-hydroxysteroid dehydrogenase type 1 (11-HSD1; encoded by the HSD11B1 gene), which normally converts cortisone to cortisol...
  34. Engelen L, Schalkwijk C, Eussen S, Scheijen J, Soedamah Muthu S, Chaturvedi N, et al. Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study. Cardiovasc Diabetol. 2015;14:67 pubmed publisher
    ..were assessed with multiple logistic regression analyses adjusted for age, sex, season, BMI, smoking, HbA1c, total-HDL-cholesterol-ratio, systolic blood pressure, antihypertensive medication, eGFR, physical activity, alcohol intake, ..
  35. Chistiakov D, Orekhov A, Bobryshev Y. ApoA1 and ApoA1-specific self-antibodies in cardiovascular disease. Lab Invest. 2016;96:708-18 pubmed publisher
    Apolipoprotein A1 (ApoA1) is a main protein moiety in high-density lipoprotein (HDL) particles. Generally, ApoA1 and HDL are considered as atheroprotective...
  36. Earle N, Poppe K, Doughty R, Rolleston A, Kerr A, Legget M. Clinical Characteristics and Burden of Risk Factors Among Patients With Early Onset Acute Coronary Syndromes: The ANZACS-QI New Zealand National Cohort (ANZACS-QI 17). Heart Lung Circ. 2018;27:568-575 pubmed publisher
    ..vs 19%), have higher body mass index (BMI) (48% vs 34% with BMI?30kg/m2), and higher total cholesterol:HDL ratios (?4.0, 70% vs 50%), all p<0.001...
  37. Oliosa P, Zaniqueli D, Alvim R, Barbosa M, Mill J. Body fat percentage is better than indicators of weight status to identify children and adolescents with unfavorable lipid profile. J Pediatr (Rio J). 2019;95:112-118 pubmed publisher
    ..Normal distribution curves of non-HDL cholesterol were designed for obese and non-obese...
  38. Wang Y, Guo X, Ma H, Lu L, Zhang R. Prokineticin-2 is associated with metabolic syndrome in a middle-aged and elderly Chinese population. Lipids Health Dis. 2016;15:1 pubmed publisher
    ..pressure (DBP), blood glucose, and serum uric acid, but decreased age, plasma high-density lipoprotein cholesterol (HDL-C), and HDL-C/total cholesterol (TC) (all P < 0.05)...
  39. Nakano M. [Disk-like complex formation by apolipoprotein-lipid membrane interaction and relevance to high-density lipoprotein formation]. Yakugaku Zasshi. 2008;128:687-93 pubmed
    ..with transmembrane ATP-binding cassette transporter A1 (ABCA1) is a crucial step for high-density lipoprotein (HDL) formation, however, its molecular mechanism is less well understood...
  40. Li H, Zhou J, Yue Z, Feng L, Luo Z, Chen S, et al. A complex association between ABCA7 genotypes and blood lipid levels in Southern Chinese Han patients of sporadic Alzheimer's disease. J Neurol Sci. 2017;382:13-17 pubmed publisher
    ..Additionally, logistic regression analysis showed that lower high-density lipoprotein cholesterol (HDL-C) levels (p=0.015, OR=5.669) and GG genotype (p=0.013, OR=8.318) were positively associated with SAD...
  41. Wan E, Fong D, Fung C, Lam C. Incidence and predictors for cardiovascular disease in Chinese patients with type 2 diabetes mellitus - a population-based retrospective cohort study. J Diabetes Complications. 2016;30:444-50 pubmed publisher
    ..and diastolic blood pressure (SBP and DBP), total cholesterol/high-density lipoprotein-cholesterol ratio (TC/HDL-C ratio) and urine albumin/creatinine ratio (ACR)...
  42. Zeng T, Tang D, Ye Y, Su J, Jiang H. Influence of SCARB1 gene SNPs on serum lipid levels and susceptibility to coronary heart disease and cerebral infarction in a Chinese population. Gene. 2017;626:319-325 pubmed publisher
    ..gene encodes human scavenger receptor class B type I (SR-BI), the primary receptor for high-density lipoprotein (HDL)- cholesteryl ester uptake, and polymorphisms in this gene may influence SR-BI protein expression and serum lipid ..
  43. Xu N, Ren Z, Zhang J, Song X, Gao Z, Jing H, et al. Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis. Int J Biol Macromol. 2017;95:204-214 pubmed publisher
    ..decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively...
  44. Jiang B, Li B, WANG Y, Han B, Wang N, Li Q, et al. The nine-year changes of the incidence and characteristics of metabolic syndrome in China: longitudinal comparisons of the two cross-sectional surveys in a newly formed urban community. Cardiovasc Diabetol. 2016;15:84 pubmed publisher
    ..In female, the combination of WC + BP + HDL disorder decreased from 29.7 % (2005) to 11...
  45. Liu J, Wang L, Qian Y, Dai J, Shen C, Jin G, et al. Association of 48 type 2 diabetes susceptibility loci with fasting plasma glucose and lipid levels in Chinese Hans. Diabetes Res Clin Pract. 2018;139:114-121 pubmed publisher
    ..0342, P?=?9.61?×?10-4) and decreased high-density lipoprotein cholesterol (HDL-C) level (??=?-0.015, P?=?3.24?×?10-3) after Bonferroni correction...
  46. Urbina E, McCoy C, Gao Z, Khoury P, Shah A, Dolan L, et al. Lipoprotein particle number and size predict vascular structure and function better than traditional lipids in adolescents and young adults. J Clin Lipidol. 2017;11:1023-1031 pubmed publisher
    ..NMR) measures of lipoprotein particle number (low-density lipoprotein [LDL] particle, low-density lipoprotein [HDL] particle, very low-density lipoprotein [VLDL] particle) and size (LDL size, HDL size, and VLDL size) to determine ..
  47. Cutuli L, Pirillo A, Uboldi P, Kuehn H, Catapano A. 15-lipoxygenase-mediated modification of HDL3 impairs eNOS activation in human endothelial cells. Lipids. 2014;49:317-26 pubmed publisher
    ..B type I (SR-BI), which plays a key role in the induction of eNOS activity mediated by high density lipoproteins (HDL)...
  48. Cui H, Cui C, Ma Y, Wang D, Huang C, Zhang A, et al. [Single nucleotide polymorphisms of genes associated with high density lipoprotein metabolism in Chinese population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:22-6 pubmed
    To study the single nucleotide polymorphisms in genes associated with the high density lipoprotein (HDL) metabolism in Chinese population.
  49. Vaillant A, Dentan G, Laurent Y, Aurélie G, Beer J, Germin F, et al. The Log book for the secondary prevention of coronary artery disease: A pilot study. Presse Med. 2015;44:e301-9 pubmed publisher
    ..009) and an increase in HDL-cholesterol (HDL-c) (P=0.165). At 1 year FU, body mass index from LB+ was more reduced than in patients LB- (P=0...
  50. Vaverková H, Karásek D, Novotný D, Halenka M, Orság J, Slavík L. Hypertriglyceridemic waist - a simple clinical tool to detect cardiometabolic risk: comparison with harmonized definition of metabolic syndrome. Physiol Res. 2015;64 Suppl 3:S385-94 pubmed
    ..The subjects with HTGW had an atherogenic lipid profile (significantly higher triglycerides, AIP, non-HDL-C, lower HDL-C and ApoA-1, and the women also higher TC and ApoB), increased markers of insulin resistance (insulin,..
  51. Liu T, Wen H, Jiang M, Yuan D, GAO P, Zhao Y, et al. Effect of dietary chromium picolinate on growth performance and blood parameters in grass carp fingerling, Ctenopharyngodon idellus. Fish Physiol Biochem. 2010;36:565-572 pubmed publisher
    ..8 mg Cr kg(-1) had higher triglyceride and high-density lipoprotein cholesterol (HDL-C) concentrations compared to other treatments...
  52. Hu A, Fatma S, Cao J, Grunstein J, Nino G, Grumbach Y, et al. Th2 cytokine-induced upregulation of 11beta-hydroxysteroid dehydrogenase-1 facilitates glucocorticoid suppression of proasthmatic airway smooth muscle function. Am J Physiol Lung Cell Mol Physiol. 2009;296:L790-803 pubmed publisher
  53. Hendijani F, Akbari V. Probiotic supplementation for management of cardiovascular risk factors in adults with type II diabetes: A systematic review and meta-analysis. Clin Nutr. 2018;37:532-541 pubmed publisher
    ..DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Other biochemical response and adverse effects were considered as secondary outcomes...
  54. Porto Arias J, Lorenzo T, Lamas A, Regal P, Cardelle Cobas A, Cepeda A. Food patterns and nutritional assessment in Galician university students. J Physiol Biochem. 2018;74:119-126 pubmed publisher
    ..90%) presented high levels of total cholesterol (>200 mg/dL), and 54.55% of women had levels of HDL-cholesterol above 60 mg/dL. Five students had levels of glucose above 100 mg/dL, being four men and one woman...
  55. Tekkeşin A, Hayıroğlu M, Zehir R, Turkkan C, Keskin M, Çinier G, et al. The use of monocyte to HDL ratio to predict postoperative atrial fibrillation after aortocoronary bypass graft surgery. North Clin Istanb. 2017;4:145-150 pubmed publisher
    ..Monocyte to HDL (M/H) ratio is a newly defined parameter of both inflammation and oxidative stress...
  56. Chroni A, Liu T, Fitzgerald M, Freeman M, Zannis V. Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. Biochemistry. 2004;43:2126-39 pubmed
    ..The findings are consistent with a direct association of different combinations of apoA-I helices with a complementary ABCA1 domain. Mutations that alter ABCA1/apoA-I association affect cholesterol efflux and inhibit biogenesis of HDL.
  57. Deary I, Hayward C, Permana P, Nair S, Whalley L, Starr J, et al. Polymorphisms in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1) and lifetime cognitive change. Neurosci Lett. 2006;393:74-7 pubmed
    A rare polymorphism in the gene encoding 11B-hydroxysteroid dehydrogenase type 1 (HSD11B1: rs846911-C/A) has been associated with an increased risk of Alzheimer's disease...
  58. Muller C, Pompon D, Urban P, Morfin R. Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2006;99:215-22 pubmed
    ..The 7alpha-hydroxy-DHEA produced by the cytochrome CYP7B1 in tissues may exert anti-glucocorticoid effects through interference with the 11beta-HSD1-mediated cortisone reduction. ..
  59. Rysz Gorzynska M, Gluba Brzozka A, Banach M. High-Density Lipoprotein and Low-Density Lipoprotein Subfractions in Patients with Chronic Kidney Disease. Curr Vasc Pharmacol. 2017;15:144-151 pubmed publisher
    ..It has been suggested that measuring and estimating changes in high density lipoprotein (HDL) and low density lipoprotein (LDL) subfractions may be important for predicting CVD in CKD patients.
  60. Farrell S, Finley C, Barlow C, Willis B, DeFina L, Haskell W, et al. Moderate to High Levels of Cardiorespiratory Fitness Attenuate the Effects of Triglyceride to High-Density Lipoprotein Cholesterol Ratio on Coronary Heart Disease Mortality in Men. Mayo Clin Proc. 2017;92:1763-1771 pubmed publisher
    ..among cardiorespiratory fitness (CRF), fasting blood triglyceride to high density lipoprotein cholesterol ratio (TG:HDL-C), and coronary heart disease (CHD) mortality in men...
  61. Out R, Hoekstra M, Meurs I, de Vos P, Kuiper J, Van Eck M, et al. Total body ABCG1 expression protects against early atherosclerotic lesion development in mice. Arterioscler Thromb Vasc Biol. 2007;27:594-9 pubmed
    ABCG1 has recently been identified as a facilitator of cholesterol and phospholipid efflux from macrophages to HDL. In bone marrow transplantation studies, we and others have now shown that the absence of macrophage ABCG1 may ..
  62. Wiersma H, Nijstad N, de Boer J, Out R, Hogewerf W, van Berkel T, et al. Lack of Abcg1 results in decreased plasma HDL cholesterol levels and increased biliary cholesterol secretion in mice fed a high cholesterol diet. Atherosclerosis. 2009;206:141-7 pubmed publisher
    The ATP Binding Cassette transporter G1 (ABCG1) has been implicated in cholesterol efflux towards HDL and reverse cholesterol transport (RCT). Biliary cholesterol secretion is considered as an important step in RCT...
  63. Bosteen M, Madsen Svarrer E, Bisgaard L, Martinussen T, Madsen M, Nielsen L, et al. Effects of apolipoprotein M in uremic atherosclerosis. Atherosclerosis. 2017;265:93-101 pubmed publisher
    ..The Apom-S1P complex associates with HDL, and may contribute to its anti-atherosclerotic effects...
  64. Rebholz S, Melchior J, Welge J, Remaley A, Davidson W, Woollett L. Effects of Multiple Freeze/Thaw Cycles on Measurements of Potential Novel Biomarkers Associated With Adverse Pregnancy Outcomes. J Clin Lab Med. 2017;2: pubmed publisher
    ..Plasma LDL-C, HDL-C, total cholesterol, and triglyceride concentrations decreased <6-7% (cholesterols) or <20% (triglyceride) ..
  65. Kailemia M, Wei W, Nguyen K, Beals E, Sawrey Kubicek L, Rhodes C, et al. Targeted measurements of O- and N-glycopeptides show that proteins in HDL particles are enriched with specific glycosylation compared to plasma. J Proteome Res. 2017;: pubmed publisher
    High density lipoprotein (HDL) particles are believed to be protective due to their inverse correlation with the prevalence of cardiovascular diseases...
  66. Karlson B, Palmer M, Nicholls S, Barter P, Lundman P. Effects of age, gender and statin dose on lipid levels: Results from the VOYAGER meta-analysis database. Atherosclerosis. 2017;265:54-59 pubmed publisher
    ..with statin-mediated changes in low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and non-HDL-C. Individual patient data (n = 32,258) were obtained from VOYAGER...
  67. Cheung C, Gan A, Fan Q, Chee M, Apte R, Khor C, et al. Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration. J Lipid Res. 2017;58:1785-1796 pubmed publisher
    ..Patients with nAMD had significantly higher concentrations of HDL and IDL compared with controls...
  68. Guirgis F, Dodani S, Moldawer L, Leeuwenburgh C, Bowman J, Kalynych C, et al. Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation. Shock. 2017;48:539-544 pubmed publisher
    High density lipoprotein (HDL) can be readily oxidized in inflammatory conditions and exhibit pro-inflammatory and dysfunctional (Dys-HDL) characteristics...
  69. Işık H, Aynioglu O, Timur H, Sahbaz A, Harma M, Can M, et al. Is Xanthine oxidase activity in polycystic ovary syndrome associated with inflammatory and cardiovascular risk factors?. J Reprod Immunol. 2016;116:98-103 pubmed publisher
    ..The basal hormone levels, triglyceride (TG) levels, TG/HDL-C (high density lipoprotein-cholesterol) ratios FPG, FPI and HOMA-IR levels were higher in PCOS patients compared ..
  70. Shao B, Tang C, Heinecke J, Oram J. Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export. J Lipid Res. 2010;51:1849-58 pubmed publisher
    ..b>HDL isolated from human atherosclerotic lesions and blood of subjects with established coronary artery disease contains ..
  71. Vaughan A, Oram J. ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. J Lipid Res. 2006;47:2433-43 pubmed
    ..These results suggest that ABCG1 and ABCG4 act in concert with ABCA1 to maximize the removal of excess cholesterol from cells and to generate cholesterol-rich lipoprotein particles...
  72. Assmann G, Gotto A. HDL cholesterol and protective factors in atherosclerosis. Circulation. 2004;109:III8-14 pubmed
    A low level of high-density lipoprotein cholesterol (HDL-C) is an important risk factor for cardiovascular disease. Epidemiological and clinical studies provide evidence that HDL-C levels are linked to rates of coronary events...
  73. Fournier N, Cogny A, Atger V, Pastier D, Goudouneche D, Nicoletti A, et al. Opposite effects of plasma from human apolipoprotein A-II transgenic mice on cholesterol efflux from J774 macrophages and Fu5AH hepatoma cells. Arterioscler Thromb Vasc Biol. 2002;22:638-43 pubmed
    ..mice (hAIItg mice) induced marked hypertriglyceridemia and low levels of plasma high density lipoprotein (HDL) with a high hapo A-II content...