Gene Symbol: Hsc70
Description: heat shock protein family A (Hsp70) member 8
Alias: HEL-33, HEL-S-72p, HSC54, HSC70, HSC71, HSP71, HSP73, HSPA10, LAP-1, LAP1, NIP71, heat shock cognate 71 kDa protein, LPS-associated protein 1, N-myristoyltransferase inhibitor protein 71, constitutive heat shock protein 70, epididymis luminal protein 33, epididymis secretory sperm binding protein Li 72p, heat shock 70kDa protein 8, heat shock 70kd protein 10, heat shock cognate protein 54, lipopolysaccharide-associated protein 1
Species: human
Products:     Hsc70

Top Publications

  1. Meacham G, Lu Z, King S, Sorscher E, Tousson A, Cyr D. The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. EMBO J. 1999;18:1492-505 pubmed
    ..Human DnaJ 2 (Hdj-2) is a co-chaperone of heat shock cognate 70 (Hsc70) which is localized to the cytosolic face of the ER...
  2. Burch A, Weller S. Nuclear sequestration of cellular chaperone and proteasomal machinery during herpes simplex virus type 1 infection. J Virol. 2004;78:7175-85 pubmed
    ..Our results suggest that HSV-1 has evolved an elegant mechanism for facilitating protein quality control at specialized foci within the nucleus. ..
  3. Matsumura Y, David L, Skach W. Role of Hsc70 binding cycle in CFTR folding and endoplasmic reticulum-associated degradation. Mol Biol Cell. 2011;22:2797-809 pubmed publisher
    ..Here we use a reconstituted cell-free system to investigate the mechanism and extent to which Hsc70 contributes to these co- and posttranslational decisions for the membrane protein cystic fibrosis transmembrane ..
  4. Grove D, Fan C, Ren H, Cyr D. The endoplasmic reticulum-associated Hsp40 DNAJB12 and Hsc70 cooperate to facilitate RMA1 E3-dependent degradation of nascent CFTRDeltaF508. Mol Biol Cell. 2011;22:301-14 pubmed publisher
    ..JB12 cooperates with cytosolic Hsc70 and the ubiquitin ligase RMA1 to target CFTR and CFTR?F508 for degradation...
  5. Orenstein S, Cuervo A. Chaperone-mediated autophagy: molecular mechanisms and physiological relevance. Semin Cell Dev Biol. 2010;21:719-26 pubmed publisher
    ..Changes with age in CMA activity and the contribution of failure of CMA to the phenotype of aging and to the pathogenesis of several age-related pathologies are also described. ..
  6. Donnelly B, Needham P, Snyder A, Roy A, Khadem S, Brodsky J, et al. Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis. J Biol Chem. 2013;288:13124-35 pubmed publisher
    ..Collectively, these observations indicate that Hsp70 and Hsp90 comprise two functionally distinct ER quality control checkpoints that sequentially monitor NCC biogenesis...
  7. Liu F, Wu S, Hu S, Hsiao C, Wang C. Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats. J Biol Chem. 1999;274:34425-32 pubmed
    Using a yeast two-hybrid system with the 70-kDa heat shock cognate protein (hsc70) or its C-terminal 30-kDa domain as baits, we isolated several proteins interacting with hsc70, including Hip/p48 and p60/Hop...
  8. Alberti S, Böhse K, Arndt V, Schmitz A, Hohfeld J. The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator. Mol Biol Cell. 2004;15:4003-10 pubmed
    ..CHIP associates with the chaperones Hsc70 and Hsp90 during the regulation of signaling pathways and during protein quality control, and directs chaperone-..
  9. Tsukahara F, Maru Y. Identification of novel nuclear export and nuclear localization-related signals in human heat shock cognate protein 70. J Biol Chem. 2004;279:8867-72 pubmed
    ..We have recently identified a novel variant of human Hsc70, heat shock cognate protein 54 (Hsc54), that lacks amino acid residues 464-616 in the protein binding and variable domains of Hsc70...

More Information


  1. Meacham G, Patterson C, Zhang W, Younger J, Cyr D. The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat Cell Biol. 2001;3:100-5 pubmed
    ..CHIP is a cytosolic U-box protein that interacts with Hsc70 through a set of tetratricorepeat motifs...
  2. Sondermann H, Scheufler C, Schneider C, Hohfeld J, Hartl F, Moarefi I. Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors. Science. 2001;291:1553-7 pubmed
    ..In a 1.9 angstrom crystal structure of a complex with the ATPase of the 70-kilodalton heat shock cognate protein (Hsc70), the Bag domain forms a three-helix bundle, inducing a conformational switch in the ATPase that is incompatible ..
  3. Shiota M, Saiwai H, Mun S, Harada A, Okada S, Odawara J, et al. Generation of a rat monoclonal antibody specific for heat shock cognate protein 70. Hybridoma (Larchmt). 2010;29:453-6 pubmed publisher
    Human heat shock cognate protein 70 (Hsc70), also known as Hsp73 and Hsp70-8, is a molecular chaperone. The human Hsp70 family comprises at least eight different molecular groups with strong homology...
  4. Thompson L, Aiken C, Kaltenbach L, Agrawal N, Illes K, Khoshnan A, et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol. 2009;187:1083-99 pubmed publisher
    ..Htt nuclear localization, cleavage, and clearance mediated by lysosomal-associated membrane protein 2A and Hsc70. We propose that IKK activates mutant Htt clearance until an age-related loss of proteasome/lysosome function ..
  5. Sen S, Webber P, West A. Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. J Biol Chem. 2009;284:36346-56 pubmed publisher
  6. Imamura Y, Fujigaki Y, Oomori Y, Usui S, Wang P. Cooperation of salivary protein histatin 3 with heat shock cognate protein 70 relative to the G1/S transition in human gingival fibroblasts. J Biol Chem. 2009;284:14316-25 pubmed publisher
    ..In this study, we found that histatin 3, a member of the histatin family, binds to heat shock cognate protein 70 (HSC70)...
  7. Walker V, Atanasiu R, Lam H, Shrier A. Co-chaperone FKBP38 promotes HERG trafficking. J Biol Chem. 2007;282:23509-16 pubmed
    ..putative HERG-interacting proteins includes several known components of the cytosolic chaperone system, including Hsc70 (70-kDa heat shock cognate protein), Hsp90 (90-kDa heat shock protein), Hdj-2, Hop (Hsp-organizing protein), and ..
  8. Mitsui K, Nakayama H, Akagi T, Nekooki M, Ohtawa K, Takio K, et al. Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. J Neurosci. 2002;22:9267-77 pubmed
    ..revealed that, in addition to ubiquitin and widely reported chaperone proteins such as heat shock cognate 70 (HSC70), human DNA J-1 (HDJ-1), and HDJ-2, the translational elongation factor-1alpha (EF-1alpha) and heat shock protein ..
  9. Gurer C, Cimarelli A, Luban J. Specific incorporation of heat shock protein 70 family members into primate lentiviral virions. J Virol. 2002;76:4666-70 pubmed
    ..cyclophilin A, we probed purified virions with antibodies against heat shock proteins Hsp27, Hsp40, Hsp60, Hsp70, Hsc70, and Hsp90...
  10. Jiang J, Ballinger C, Wu Y, Dai Q, Cyr D, Hohfeld J, et al. CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation. J Biol Chem. 2001;276:42938-44 pubmed
    ..CHIP (carboxyl terminus of Hsc70-interacting protein) is such a cofactor that interacts with Hsc70 and, in general, attenuates its most well ..
  11. Ballinger C, Connell P, Wu Y, Hu Z, Thompson L, Yin L, et al. Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions. Mol Cell Biol. 1999;19:4535-45 pubmed
    The chaperone function of the mammalian 70-kDa heat shock proteins Hsc70 and Hsp70 is modulated by physical interactions with four previously identified chaperone cofactors: Hsp40, BAG-1, the Hsc70-interacting protein Hip, and the Hsc70-..
  12. Elliott E, Tsvetkov P, Ginzburg I. BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. J Biol Chem. 2007;282:37276-84 pubmed
    ..Hsp70/Hsc70, a member of the chaperone protein family, interacts with Tau protein and mediates proper folding of Tau and can ..
  13. Vila Carriles W, Zhou Z, Bubien J, Fuller C, Benos D. Participation of the chaperone Hsc70 in the trafficking and functional expression of ASIC2 in glioma cells. J Biol Chem. 2007;282:34381-91 pubmed
    ..We now hypothesize that ASIC2 trafficking in glioma cells is regulated by a specific chaperone protein, namely Hsc70. Our results demonstrated that Hsc70 co-immunoprecipitates with ASIC2 and that it is overexpressed in glioma cells ..
  14. Wang L, Liu Y, Hao R, Chen L, Chang Z, Wang H, et al. Molecular mechanism of the negative regulation of Smad1/5 protein by carboxyl terminus of Hsc70-interacting protein (CHIP). J Biol Chem. 2011;286:15883-94 pubmed publisher
    ..The C terminus of Hsc70-interacting protein (CHIP) serves as an E3 ubiquitin ligase to mediate the degradation of Smad proteins and many ..
  15. Arndt V, Daniel C, Nastainczyk W, Alberti S, Hohfeld J. BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell. 2005;16:5891-900 pubmed
    ..We recently identified a degradation pathway, on which the chaperone Hsc70 delivers chaperone clients, such as misfolded forms of the cystic fibrosis transmembrane conductance regulator (..
  16. Kabuta T, Furuta A, Aoki S, Furuta K, Wada K. Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy. J Biol Chem. 2008;283:23731-8 pubmed publisher
    ..In this study, we found that UCH-L1 physically interacts with LAMP-2A, the lysosomal receptor for CMA, and Hsc70 and Hsp90, which can function as components of the CMA pathway...
  17. Tzankov S, Wong M, Shi K, Nassif C, Young J. Functional divergence between co-chaperones of Hsc70. J Biol Chem. 2008;283:27100-9 pubmed publisher
    The ATPase cycle of the chaperone Hsc70 is regulated by co-chaperones; Hsp40/DnaJ-related proteins stimulate ATP hydrolysis by Hsc70 and can bind unfolded polypeptides themselves...
  18. Takayama S, Xie Z, Reed J. An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. J Biol Chem. 1999;274:781-6 pubmed
    ..BAG-1 binds the ATPase domains of Hsp70 and Hsc70, modulating their chaperone activity and functioning as a competitive antagonist of the co-chaperone Hip...
  19. Takayama S, Bimston D, Matsuzawa S, Freeman B, Aime Sempe C, Xie Z, et al. BAG-1 modulates the chaperone activity of Hsp70/Hsc70. EMBO J. 1997;16:4887-96 pubmed
    ..We present evidence that the protein BAG-1 is a potential modulator of the molecular chaperones, Hsp70 and Hsc70. BAG-1 binds to the ATPase domain of Hsp70 and Hsc70, without requirement for their carboxy-terminal peptide-..
  20. Stankiewicz M, Nikolay R, Rybin V, Mayer M. CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70-bound substrates. FEBS J. 2010;277:3353-67 pubmed publisher
    The E3 ubiquitin ligase CHIP (C-terminus of Hsc70-interacting protein) is believed to be a central player in the cellular triage decision, as it links the molecular chaperones Hsp70/Hsc70 and Hsp90 to the ubiquitin proteasomal ..
  21. Brive L, Takayama S, Briknarová K, Homma S, Ishida S, Reed J, et al. The carboxyl-terminal lobe of Hsc70 ATPase domain is sufficient for binding to BAG1. Biochem Biophys Res Commun. 2001;289:1099-105 pubmed
    The molecular co-chaperone BAG1 and other members of the BAG family bind to Hsp70/Hsc70 heat shock proteins through a conserved BAG domain that interacts with the ATPase domain of the chaperone...
  22. Rubenstein R, Zeitlin P. Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR. Am J Physiol Cell Physiol. 2000;278:C259-67 pubmed
    ..4PBA modulates the targeting of DeltaF508-CFTR for ubiquitination and degradation by reducing the expression of Hsc70 in cystic fibrosis epithelial cells. IB3-1 cells (genotype DeltaF508/W1282X) that were treated with 0...
  23. Tsukahara F, Yoshioka T, Muraki T. Molecular and functional characterization of HSC54, a novel variant of human heat-shock cognate protein 70. Mol Pharmacol. 2000;58:1257-63 pubmed
    A novel variant of human heat-shock cognate protein 70 (HSC70) transcript, named heat-shock cognate protein 54 (HSC54), was identified and characterized...
  24. Younger J, Ren H, Chen L, Fan C, Fields A, Patterson C, et al. A foldable CFTR{Delta}F508 biogenic intermediate accumulates upon inhibition of the Hsc70-CHIP E3 ubiquitin ligase. J Cell Biol. 2004;167:1075-85 pubmed
    ..in a kinetically trapped, but folding competent conformation, that is maintained in a soluble state by cytosolic Hsc70. Ubiquitination of Hsc70-bound CFTRDeltaF508 requires CHIP, a U box containing cytosolic cochaperone...
  25. Han C, Chen T, Li N, Yang M, Wan T, Cao X. HDJC9, a novel human type C DnaJ/HSP40 member interacts with and cochaperones HSP70 through the J domain. Biochem Biophys Res Commun. 2007;353:280-5 pubmed
    ..HDJC9 can interact with HSP70s and activate the ATPase activity of HSP70s, both of which are dependent on the J domain. Our data suggest that HDJC9 is a novel cochaperone for HSP70s. ..
  26. Welch W, Mizzen L. Characterization of the thermotolerant cell. II. Effects on the intracellular distribution of heat-shock protein 70, intermediate filaments, and small nuclear ribonucleoprotein complexes. J Cell Biol. 1988;106:1117-30 pubmed
    ..Similarly, the disruption of intranuclear staining patterns of the small nuclear ribonucleoprotein complexes after heat-shock treatment was less apparent in tolerant cells exposed to a subsequent heat-shock treatment. ..
  27. Zhang H, McGlone C, Mannion M, Page R. 1H, 15N and 13C resonance assignments for free and IEEVD peptide-bound forms of the tetratricopeptide repeat domain from the human E3 ubiquitin ligase CHIP. Biomol NMR Assign. 2017;11:5-9 pubmed publisher
    ..CHIP catalyzes covalent attachment of ubiquitin to unfolded proteins chaperoned by the heat shock proteins Hsp70/Hsc70 and Hsp90...
  28. Cid C, Garcia Bonilla L, Camafeita E, Burda J, Salinas M, Alcazar A. Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance. Proteomics. 2007;7:3207-18 pubmed
    ..It supports a potential role of PP1 in IR stress and as a target of the endogenous protective mechanisms induced by IT. ..
  29. Selvakumar P, Lakshmikuttyamma A, Lawman Z, Bonham K, Dimmock J, Sharma R. Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29. Biochem Biophys Res Commun. 2004;322:1012-7 pubmed
    ..In this study, we examined the levels of expression of MetAP2, NMT, and NMT inhibitor protein 71 (NIP71) in human colon cancer cell lines (HCCLs)...
  30. Choi H, Liew H, Jang A, Kim Y, Lashuel H, Suh Y. Phosphorylation of ?-synuclein is crucial in compensating for proteasomal dysfunction. Biochem Biophys Res Commun. 2012;424:597-603 pubmed publisher
    ..As a result, protein tyrosine phosphatase 1B inhibitor may be used as a potential therapeutic agent against Parkinson's disease. ..
  31. Pakdaman Y, Sanchez Guixé M, Kleppe R, Erdal S, Bustad H, Bjørkhaug L, et al. In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins. Biosci Rep. 2017;37: pubmed publisher
    ..containing protein 1 (STUB1) gene encoding the ubiquitin E3 ligase and dimeric co-chaperone C-terminus of Hsc70-interacting protein (CHIP)...
  32. Rahmani P, Rogalski T, Moerman D. The C. elegans UNC-23 protein, a member of the BCL-2-associated athanogene (BAG) family of chaperone regulators, interacts with HSP-1 to regulate cell attachment and maintain hypodermal integrity. Worm. 2015;4:e1023496 pubmed publisher
    ..These proteins bind to and modulate the activity of the ATPase domain of the heat shock cognate protein 70, Hsc70. We have isolated missense mutations in the ATPase domain of the C...
  33. Alam S, Rochon D. Evidence that Hsc70 Is Associated with Cucumber Necrosis Virus Particles and Plays a Role in Particle Disassembly. J Virol. 2017;91: pubmed publisher
    ..We have found through Western blot analysis and mass spectrometry that the HSP70 homolog Hsc70-2 copurifies with CNV particles...
  34. Gorenberg E, Chandra S. The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease. Front Neurosci. 2017;11:248 pubmed publisher
    ..These co-chaperones contain a conserved J domain through which they form a complex with heat shock cognate 70 (Hsc70), enhancing the chaperone's ATPase activity...
  35. Shiba H, Yabu T, Sudayama M, Mano N, Arai N, Nakanishi T, et al. Sequential steps of macroautophagy and chaperone-mediated autophagy are involved in the irreversible process of posterior silk gland histolysis during metamorphosis of Bombyx mori. J Exp Biol. 2016;219:1146-53 pubmed publisher
    ..The proteasome activity was high at V6 and PS but low at SP and CO. In the isolated lysosome fractions, levels of Hsc70/Hsp70 protein began to increase at PS and continued to rise at SP and CO...
  36. Gulic T, Laskarin G, Dominovic M, Glavan Gacanin L, Babarović E, Haller H, et al. Potential role of heat-shock protein 70 and interleukin-15 in the pathogenesis of threatened spontaneous abortions. Am J Reprod Immunol. 2016;76:126-36 pubmed publisher
    ..The percentage of single Hsp70(+) , Hsc70(+) , and IL-15(+) cells and mRNA levels of HSP70, CD91, and TLR4 were lower in the decidua basalis in cases of ..
  37. Gao X, Carroni M, Nussbaum Krammer C, Mogk A, Nillegoda N, Szlachcic A, et al. Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils. Mol Cell. 2015;59:781-93 pubmed publisher
    ..Specifically, the Hsc70 chaperone, the class B J-protein DNAJB1, and an Hsp110 family nucleotide exchange factor (NEF) provide ATP-..
  38. Sahu R, Kaushik S, Clement C, Cannizzo E, Scharf B, Follenzi A, et al. Microautophagy of cytosolic proteins by late endosomes. Dev Cell. 2011;20:131-9 pubmed publisher
    ..Protein cargo selection is mediated by the chaperone hsc70 and requires the cationic domain of hsc70 for electrostatic interactions with the endosomal membrane...
  39. Nunes S, Calderwood S. Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells. Biochem Biophys Res Commun. 1995;213:1-6 pubmed
    Interaction of heat shock transcription factor-1 (HSF-1) with the seventy kilodalton heat shock cognate protein (HSC70) was examined in NIH 3T3 cells...
  40. Assimon V, Southworth D, Gestwicki J. Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation. Biochemistry. 2015;54:7120-31 pubmed publisher
    ..cochaperones, CHIP, Hop, DnaJC7, FKBP51, and FKBP52, for the C-termini of four members of the chaperone family, Hsc70, Hsp72, Hsp90α, and Hsp90β, in vitro...
  41. Zhang B, Peng Y, Zheng J, Liang L, Hoffmann A, Ma C. Response of heat shock protein genes of the oriental fruit moth under diapause and thermal stress reveals multiple patterns dependent on the nature of stress exposure. Cell Stress Chaperones. 2016;21:653-63 pubmed publisher
    ..Expression of Hsp40, 70, and Hsc70 family members increased in OFM undergoing diapause, while Hsp90 was downregulated...
  42. Dyer J, Dutta A, Gogol M, Weake V, Dialynas G, Wu X, et al. Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression. J Mol Biol. 2017;429:2093-2107 pubmed publisher
    ..MLF as a member of a nuclear chaperone complex containing a DnaJ protein, BCL2-associated anthanogene 2, and Hsc70. This complex associates with chromatin and regulates the expression of target genes...
  43. Bański P, Mahboubi H, Kodiha M, Shrivastava S, Kanagaratham C, Stochaj U. Nucleolar targeting of the chaperone hsc70 is regulated by stress, cell signaling, and a composite targeting signal which is controlled by autoinhibition. J Biol Chem. 2010;285:21858-67 pubmed publisher
    ..studies were undertaken to characterize the signaling events and the targeting sequence required to concentrate hsc70 in the nucleoli of human cells...
  44. Manceau V, Gavet O, Curmi P, Sobel A. Stathmin interaction with HSC70 family proteins. Electrophoresis. 1999;20:409-17 pubmed
    ..search for further functional partners of stathmin, we identified proteins in the Hsp70 family, and in particular Hsc70, as interacting with stathmin in vitro...
  45. Yahata T, de Caestecker M, Lechleider R, Andriole S, Roberts A, Isselbacher K, et al. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J Biol Chem. 2000;275:8825-34 pubmed
    ..We also found that the Hsc70 heat-shock cognate protein also forms complex with MSG1 in vivo, suppressing both binding of MSG1 to p300/CBP and ..
  46. Rudenko I, Kaganovich A, Langston R, Beilina A, Ndukwe K, Kumaran R, et al. The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2. Biochem J. 2017;474:1547-1558 pubmed publisher
    ..affinity of G2385R compared with the wild-type protein for two proteins involved in proteasomal degradation, Hsc70 and carboxyl-terminus of Hsc70-interacting protein (CHIP)...
  47. Liu L, Cheng T, Yang Y. Cloning and expression pattern of a heat shock cognate protein 70 gene in ticks (Haemaphysalis flava). Parasitol Res. 2017;116:1695-1703 pubmed publisher
    ..In current study, we focused on cloning the full-length gene encoding a heat shock cognate protein 70 (Hsc70), a molecular chaperone of critical functional roles belonging to heat shock protein 70 (HSP70) family, in ..
  48. Tremp A, Sharma V, Carter V, Lasonder E, Dessens J. LCCL protein complex formation in Plasmodium is critically dependent on LAP1. Mol Biochem Parasitol. 2017;214:87-90 pubmed publisher
    ..Our results show that abundant complexes containing LAP1, LAP2 and LAP3 are formed in gametocytes through high avidity interactions...
  49. Akakura S, Yoshida M, Yoneda Y, Horinouchi S. A role for Hsc70 in regulating nucleocytoplasmic transport of a temperature-sensitive p53 (p53Val-135). J Biol Chem. 2001;276:14649-57 pubmed
    ..Molecular chaperones such as Hsc70 were associated with p53(Val-135) at 37 degrees C but not at 32 degrees C...
  50. Demircioglu F, Sosa B, Ingram J, Ploegh H, Schwartz T. Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia. elife. 2016;5: pubmed publisher
    ..the ΔE mutation is known to diminish binding of two TorsinA ATPase activators: lamina-associated protein 1 (LAP1) and its paralog, luminal domain like LAP1 (LULL1)...
  51. Hansberg Pastor V, González Arenas A, Camacho Arroyo I. CCAAT/enhancer binding protein ? negatively regulates progesterone receptor expression in human glioblastoma cells. Mol Cell Endocrinol. 2017;439:317-327 pubmed publisher
    ..PR-B expression regulation in glioblastoma cell lines, which expressed different ratios of PR and C/EBP? isoforms (LAP1, LAP2, and LIP)...
  52. Narayan V, Landré V, Ning J, Hernychova L, Muller P, Verma C, et al. Protein-Protein Interactions Modulate the Docking-Dependent E3-Ubiquitin Ligase Activity of Carboxy-Terminus of Hsc70-Interacting Protein (CHIP). Mol Cell Proteomics. 2015;14:2973-87 pubmed publisher
  53. Mikolajczyk M, Nelson M. Regulation of stability of cyclin-dependent kinase CDK11p110 and a caspase-processed form, CDK11p46, by Hsp90. Biochem J. 2004;384:461-7 pubmed
    ..These results indicate that Hsp90 and cdc37 stabilize CDK11 kinase, and suggest that this stabilization is crucial for its pro-apoptotic function. ..
  54. Ferreira J, Fôfo H, Bejarano E, Bento C, Ramalho J, Girao H, et al. STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. Autophagy. 2013;9:1349-66 pubmed publisher
  55. Zheng W, Dong X, Yin R, Xu F, Ning H, Zhang M, et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014;32:2278-89 pubmed publisher
    ..Microarray analysis suggested that EDAG knockdown selectively inhibits GATA1-activated target genes. These data provide novel insights into EDAG in regulation of erythroid differentiation. ..
  56. Bozidis P, Hyphantis T, Mantas C, Sotiropoulou M, Antypa N, Andreoulakis E, et al. HSP70 polymorphisms in first psychotic episode drug-naïve schizophrenic patients. Life Sci. 2014;100:133-7 pubmed publisher
    ..Present findings indicate a role of HSP8A in FEP and underline the importance of including personality traits in the study of the factors associated with the development of schizophrenia. ..
  57. Shi Y, Chan D, Jung S, Malovannaya A, Wang Y, Qin J. A data set of human endogenous protein ubiquitination sites. Mol Cell Proteomics. 2011;10:M110.002089 pubmed publisher
    ..Mitochondrial proteins constitute 14.7% of this data set, implicating ubiquitination in a wide range of mitochondrial functions. ..
  58. Wang B, Yang Y, Yang H, Liu Y, Hao J, Zhang Y, et al. PKC? counteracts oxidative stress by regulating Hsc70 in an esophageal cancer cell line. Cell Stress Chaperones. 2013;18:359-66 pubmed publisher
    ..spectrometry approach and immunoprecipitation/immunoblot analysis, we found that heat shock cognate protein 70 (Hsc70) was involved in the complex formed by atypical protein kinase C? (PKC?) and LC3 in the esophageal cancer cell ..
  59. Woods W, Boettcher J, Zhou D, Kloepper K, Hartman K, Ladror D, et al. Conformation-specific binding of alpha-synuclein to novel protein partners detected by phage display and NMR spectroscopy. J Biol Chem. 2007;282:34555-67 pubmed
    ..These results confirm that the helical N terminus of AS can mediate specific interactions with other proteins and suggest that membrane binding may regulate the physiological activity of AS in vivo. ..
  60. Laederich M, Degnin C, Lunstrum G, Holden P, Horton W. Fibroblast growth factor receptor 3 (FGFR3) is a strong heat shock protein 90 (Hsp90) client: implications for therapeutic manipulation. J Biol Chem. 2011;286:19597-604 pubmed publisher
    ..Our results establish FGFR3 as a strong Hsp90 client and suggest that modulating Hsp90 chaperone complexes may beneficially influence the stability and function of FGFR3 in disease. ..
  61. Fitter S, Gronthos S, Ooi S, Zannettino A. The Mesenchymal Precursor Cell Marker Antibody STRO-1 Binds to Cell Surface Heat Shock Cognate 70. Stem Cells. 2017;35:940-951 pubmed publisher
    ..Western blotting and Tandem mass spectroscopy, we have identified the STRO-1 antigen as heat shock cognate 70 (HSC70;HSPA8). STRO-1 binds to immune-precipitated HSC70 and siRNA-mediated knock down of HSPA8 reduced STRO-1 binding...
  62. Giommarelli C, Zuco V, Favini E, Pisano C, Dal Piaz F, De Tommasi N, et al. The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Cell Mol Life Sci. 2010;67:995-1004 pubmed publisher
  63. Cheng W, Li D, Wang Y, Liu Y, Zhu Salzman K. Cloning of heat shock protein genes (hsp70, hsc70 and hsp90) and their expression in response to larval diapause and thermal stress in the wheat blossom midge, Sitodiplosis mosellana. J Insect Physiol. 2016;95:66-77 pubmed publisher
    ..To explore the potential roles of heat shock proteins (hsp) in this process, we cloned full-length cDNAs of hsp70, hsc70 and hsp90 from S...
  64. Shin J, Méndez López I, Hong M, Wang Y, Tanji K, Wu W, et al. Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth. Hum Mol Genet. 2017;26:65-78 pubmed publisher
    Lamina-associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that has been implicated in striated muscle maintenance. Mutations in its gene have been linked to muscular dystrophy and cardiomyopathy...
  65. Dong Q, Men R, Dan X, Chen Y, Li H, Chen G, et al. Hsc70 regulates the IRES activity and serves as an antiviral target of enterovirus A71 infection. Antiviral Res. 2018;150:39-46 pubmed publisher
    ..Here we show that heat shock cognate protein 70 (Hsc70), a molecular chaperone, displays pivotal role in viral infections...
  66. Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, et al. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circ Res. 2011;108:458-68 pubmed publisher
    ..Heat shock protein (Hsp)70 is known to promote maturation of hERG. Hsp70 and heat shock cognate (Hsc70) 70 has been suggested to play a similar function. However, Hsc70 has recently been reported to counteract Hsp70...
  67. Reyes del Valle J, Chavez Salinas S, Medina F, Del Angel R. Heat shock protein 90 and heat shock protein 70 are components of dengue virus receptor complex in human cells. J Virol. 2005;79:4557-67 pubmed
    ..Moreover, methyl-beta-cyclodextrin, a raft-disrupting drug, inhibits dengue virus infection, supporting the idea that cholesterol-rich membrane fractions are important in dengue virus entry. ..
  68. Rubenstein R, Lyons B. Sodium 4-phenylbutyrate downregulates HSC70 expression by facilitating mRNA degradation. Am J Physiol Lung Cell Mol Physiol. 2001;281:L43-51 pubmed
    ..4PBA downregulates protein and mRNA expression of the heat shock cognate protein HSC70 (the constitutively expressed member of the 70-kDa heat shock protein family) by approximately 40-50% and ..
  69. Rebelo S, da Cruz e Silva E, da Cruz e Silva O. Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy. Mutat Res Rev Mutat Res. 2015;766:42-7 pubmed publisher
    Lamina-associated polypeptide 1 (LAP1) is a ubiquitously expressed integral protein of the inner nuclear membrane...
  70. El Kasaby A, Koban F, Sitte H, Freissmuth M, Sucic S. A cytosolic relay of heat shock proteins HSP70-1A and HSP90β monitors the folding trajectory of the serotonin transporter. J Biol Chem. 2014;289:28987-9000 pubmed publisher
    ..Consistent with an HSP relay, co-chaperones (e.g. HSC70-HSP90-organizing protein) were co-immunoprecipitated with the stalled mutants SERT-R607A/I608A and SERT-P601A/..
  71. Ding Y, Song N, Liu C, He T, Zhuo W, He X, et al. Heat shock cognate 70 regulates the translocation and angiogenic function of nucleolin. Arterioscler Thromb Vasc Biol. 2012;32:e126-34 pubmed publisher
    ..The present study discovered that heat shock cognate 70 (Hsc70) is essential in both the surface translocation and the angiogenic function of NCL...
  72. Kaufer S, Coffey C, Parker J. The cellular chaperone hsc70 is specifically recruited to reovirus viral factories independently of its chaperone function. J Virol. 2012;86:1079-89 pubmed publisher
    ..Here we examined the localization of the cellular chaperone Hsc70 and found that it colocalizes with VFs in infected cells and also with viral factory-like structures (VFLs) formed ..
  73. Aressy B, Jullien D, Cazales M, Marcellin M, Bugler B, Burlet Schiltz O, et al. A screen for deubiquitinating enzymes involved in the G?/M checkpoint identifies USP50 as a regulator of HSP90-dependent Wee1 stability. Cell Cycle. 2010;9:3815-22 pubmed publisher
    ..We propose that USP50 may act through a HSP90-dependent mechanism to counteract CDC25B mitotic inducing activity and prevent Wee1 degradation, thereby repressing entry into mitosis following activation of the DNA damage checkpoint. ..
  74. Hirayama S, Yamazaki Y, Kitamura A, Oda Y, Morito D, Okawa K, et al. MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination. Mol Biol Cell. 2008;19:899-911 pubmed
    ..disease-causing mutants of MKKS are rapidly degraded via the ubiquitin-proteasome pathway in a manner dependent on HSC70 interacting protein (CHIP), a chaperone-dependent ubiquitin ligase...
  75. Wehner P, Nielsen B, Hokland M. Expression levels of hsc70 and hsp60 are developmentally regulated during B-cell maturation and not associated to childhood c-ALL at presentation or relapse. Eur J Haematol. 2003;71:100-8 pubmed
    ..gel electrophoresis for determining whether either the constitutive chaperonic heat shock cognate protein 70 (hsc70) or heat shock protein 60 (hsp60) contribute to B-cell differentiation and leukemogenesis...
  76. Fekete A, Treszl A, Tóth Heyn P, Vannay A, Tordai A, Tulassay T, et al. Association between heat shock protein 72 gene polymorphism and acute renal failure in premature neonates. Pediatr Res. 2003;54:452-5 pubmed
    ..We have investigated the association of genetic polymorphisms of the constitutive HSP70 (HSP73) and the inducible HSP70 (HSP72) encoding genes with the risk of acute renal failure (ARF) in very low birth ..
  77. Yan Y, Wang H, Hu M, Jiang L, Wang Y, Liu P, et al. HDAC6 Suppresses Age-Dependent Ectopic Fat Accumulation by Maintaining the Proteostasis of PLIN2 in Drosophila. Dev Cell. 2017;43:99-111.e5 pubmed publisher
    ..We show that HDAC6 is associated physically with the chaperone protein dHsc4/Hsc70 to maintain the proteostasis of PLIN2...
  78. Benaroudj N, Batelier G, Triniolles F, Ladjimi M. Self-association of the molecular chaperone HSC70. Biochemistry. 1995;34:15282-90 pubmed
    The self-association properties of the molecular chaperone HSC70 have been analyzed by a wide range of biochemical and biophysical techniques...
  79. Hino H, Dai P, Yoshida T, Hatakeyama T, Harada Y, Otsuji E, et al. Interaction of Cx43 with Hsc70 regulates G1/S transition through CDK inhibitor p27. Sci Rep. 2015;5:15365 pubmed publisher
    ..We have demonstrated that Cx43 interacts with heat shock cognate protein 70 (Hsc70) for regulating cell proliferation...
  80. Luciano M, Lind P, Deary I, Payton A, Posthuma D, Butcher L, et al. Testing replication of a 5-SNP set for general cognitive ability in six population samples. Eur J Hum Genet. 2008;16:1388-95 pubmed publisher
    ..01, P=0.57), indicating that this SNP set was not associated with general cognitive ability in the populations studied. ..