Gene Symbol: HRMT1L1
Description: protein arginine methyltransferase 2
Alias: HRMT1L1, protein arginine N-methyltransferase 2, HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1, HMT1 hnRNP methyltransferase-like 1, PRMT2 alpha, PRMT2 beta, PRMT2 gamma, histone-arginine N-methyltransferase PRMT2
Species: human
Products:     HRMT1L1

Top Publications

  1. Lee H, Park M, Choi A, An J, Yang W, Shin K. Potential forensic application of DNA methylation profiling to body fluid identification. Int J Legal Med. 2012;126:55-62 pubmed publisher
  2. Su X, Zhu G, Ding X, Lee S, Dou Y, Zhu B, et al. Molecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014;28:622-36 pubmed publisher
    ..Mutagenesis of Spindlin1 reader pockets impairs activation of Wnt target genes. Taken together, our work connects a histone "lysine-arginine" methylation pattern readout by Spindlin1-to-Wnt signaling at the transcriptional level. ..
  3. Dai G, Li B, Xu Y, Zeng Z, Yang H. Oxymatrine prevents the development of monocrotaline-induced pulmonary hypertension via regulation of the NG, NG-dimethyl-L-arginine metabolism pathways in rats. Eur J Pharmacol. 2018;: pubmed publisher
    ..05). These results suggest that oxymatrine may offer protective effects on the development of pulmonary hypertension by ameliorating pulmonary remodeling and modulating the ADMA metabolism pathway. ..
  4. Dong F, Li Q, Yang C, Huo D, Wang X, Ai C, et al. PRMT2 links histone H3R8 asymmetric dimethylation to oncogenic activation and tumorigenesis of glioblastoma. Nat Commun. 2018;9:4552 pubmed publisher
    ..Together, this study demonstrates that PRMT2 acts as a transcriptional co-activator for oncogenic gene expression programs in GBM pathogenesis and provides a rationale for PRMT2 targeting in aggressive gliomas. ..
  5. Hou W, Nemitz S, Schopper S, Nielsen M, Kessels M, Qualmann B. Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl. Dev Cell. 2018;45:262-275.e8 pubmed publisher
    ..Therefore, arginine methylation is a regulatory mechanism reaching beyond controlling nuclear processes. It also controls a major, cytosolic, cytoskeletal component shaping neuronal cells. ..
  6. Matsson H, Huss M, Persson H, Einarsdottir E, Tiraboschi E, Nopola Hemmi J, et al. Polymorphisms in DCDC2 and S100B associate with developmental dyslexia. J Hum Genet. 2015;60:399-401 pubmed publisher
    ..Our findings further strengthen the role of DCDC2 and implicate S100B, in the biology of reading and spelling. ..
  7. Wang Y, Wang J, Chen C, Chen Y, Li C. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Mol Phylogenet Evol. 2015;84:101-11 pubmed publisher
    ..The BBRD method thus provided a great tool to construct a reliable tree for members of protein families through evolution. ..
  8. Zhu S, Xu Y, Song M, Chen G, Wang H, Zhao Y, et al. PRDM16 is associated with evasion of apoptosis by prostatic cancer cells according to RNA interference screening. Mol Med Rep. 2016;14:3357-61 pubmed publisher
    ..In conclusion, the present study indicated an important oncogenic role of sPRDM16/MEL1S in PCa and suggested that PRDM16 may represent a novel therapeutic target. ..
  9. Baumann C, Olson M, Wang K, Fazleabas A, De La Fuente R. Arginine methyltransferases mediate an epigenetic ovarian response to endometriosis. Reproduction. 2015;150:297-310 pubmed publisher

More Information


  1. Cura V, Marechal N, Troffer Charlier N, Strub J, van Haren M, Martin N, et al. Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J. 2017;284:77-96 pubmed publisher
  2. Xu H, Xu S, Mo K. [Transcription of protein arginine N-methyltransferase genes in mouse dorsal root ganglia following peripheral nerve injury]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1620-1625 pubmed
    ..Periphery nerve injury induces Carm1 upregulation and Prmt8 downregulation in the injured DRG in mice, which sheds light on new targets for treatment of neuropathic pain. ..
  3. Vicente F, Vespa G, Miller A, Haymond S. Quantification of Arginine and Its Methylated Derivatives in Plasma by High-Performance Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Methods Mol Biol. 2016;1378:21-30 pubmed publisher
  4. Katsanis N, Yaspo M, Fisher E. Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene. Mamm Genome. 1997;8:526-9 pubmed
  5. Yoshimoto T, Boehm M, Olive M, Crook M, San H, Langenickel T, et al. The arginine methyltransferase PRMT2 binds RB and regulates E2F function. Exp Cell Res. 2006;312:2040-53 pubmed
    ..Taken together, these findings demonstrate a novel mechanism for the regulation of E2F activity by a member of the protein arginine methyltransferase family. ..
  6. Pak M, Lakowski T, Thomas D, Vhuiyan M, Hüsecken K, Frankel A. A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity. Biochemistry. 2011;50:8226-40 pubmed publisher
    ..On the basis of our findings, we propose that PRMT1 serves as the major methyltransferase in cells by forming higher-order oligomers with itself, PRMT2, and possibly other PRMTs. ..
  7. Campbell M, Chang P, Huerta S, Izumiya C, Davis R, Tepper C, et al. Protein arginine methyltransferase 1-directed methylation of Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen. J Biol Chem. 2012;287:5806-18 pubmed publisher
    ..These results suggest that residue 20 is important for modulation of a subset of LANA functions and properties of this residue, including the hydrophobic character induced by arginine methylation, may contribute to the observed effects. ..
  8. Scott H, Antonarakis S, Lalioti M, Rossier C, Silver P, Henry M. Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2). Genomics. 1998;48:330-40 pubmed
    ..We now present the identification and characterization of two putative human arginine methyltransferases termed HRMT1L1 and HRMT1L2...
  9. Oh T, Bailey P, Dray E, Smith A, Goode J, Eriksson N, et al. PRMT2 and ROR? expression are associated with breast cancer survival outcomes. Mol Endocrinol. 2014;28:1166-85 pubmed publisher
    ..This study demonstrates the role and significant correlation between a histone methyltransferase (PRMT2)-dependent signature, ROR?, the cell-cycle regulation, DNA repair circuits, and breast cancer survival outcomes. ..
  10. Zhong J, Cao R, Hong T, Yang J, Zu X, Xiao X, et al. Identification and expression analysis of a novel transcript of the human PRMT2 gene resulted from alternative polyadenylation in breast cancer. Gene. 2011;487:1-9 pubmed publisher
    The arginine N-methyltransferase 2 protein (PRMT2, also known as HRMT1L1) is thought to act as a coactivator of ER?. The present results show the occurrence of a novel transcript by alternative polyadenylation in the human PRMT2 gene...
  11. Hussein M, Shrestha E, Ouimet M, Barrett T, Leone S, Moore K, et al. LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PLoS ONE. 2015;10:e0135218 pubmed publisher
    ..Thus, PRMT2 represents a glucose-sensitive factor that plays a role in LXR-mediated ABCA1-dependent cholesterol efflux and lends insight to the presence of increased atherosclerosis in diabetic patients. ..
  12. Crisci A, Raleff F, Bagdiul I, Raabe M, Urlaub H, Rain J, et al. Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins. Nucleic Acids Res. 2015;43:10456-73 pubmed publisher
    ..In addition, these findings may have implications for alternative splicing decisions. ..
  13. Lakowski T, Frankel A. Kinetic analysis of human protein arginine N-methyltransferase 2: formation of monomethyl- and asymmetric dimethyl-arginine residues on histone H4. Biochem J. 2009;421:253-61 pubmed publisher
    ..Although PRMT2 activity is substantially lower than PRMT1 in vitro, the fact that both enzymes selectively methylate histone H4 suggest that PRMT2, like PRMT1, may act as a transcription co-activator through this modification. ..
  14. Chan J, Hsieh T, Liu S, Chou W, Chung M, Huang S. Physical and functional interactions between hnRNP K and PRMT family proteins. FEBS Lett. 2009;583:281-6 pubmed publisher
    ..We believe these observations will help provide insights into the regulation of hnRNP K protein functions via the recruitment of its associated proteins, including its arginine methylation-modifying proteins...
  15. Ganesh L, Yoshimoto T, Moorthy N, Akahata W, Boehm M, Nabel E, et al. Protein methyltransferase 2 inhibits NF-kappaB function and promotes apoptosis. Mol Cell Biol. 2006;26:3864-74 pubmed
    ..Taken together, these data suggest that PRMT2 inhibits cell activation and promotes programmed cell death through this NF-kappaB-dependent mechanism. ..
  16. Blanc R, Richard S. Arginine Methylation: The Coming of Age. Mol Cell. 2017;65:8-24 pubmed publisher
    ..This review describes the recent molecular advances that have been uncovered in normal and diseased mammalian cells. ..
  17. Meyer R, Wolf S, Obendorf M. PRMT2, a member of the protein arginine methyltransferase family, is a coactivator of the androgen receptor. J Steroid Biochem Mol Biol. 2007;107:1-14 pubmed
    ..Thus, it appears that the ligand-dependent AR conformation is essential for the recruitment and nuclear translocation of PMRT2 which acts as AR-coactivator, presumably by arginine methylation. ..
  18. Kzhyshkowska J, Schutt H, Liss M, Kremmer E, Stauber R, Wolf H, et al. Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1. Biochem J. 2001;358:305-14 pubmed
    ..Using yeast two-hybrid screening we identified HRMT1L1 (PRMT2) as one of the proteins interacting with E1B-AP5...
  19. Qi C, Chang J, Zhu Y, Yeldandi A, Rao S, Zhu Y. Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha. J Biol Chem. 2002;277:28624-30 pubmed
    ..In this respect PRMT2 differs from coactivators PRMT1 and CARM1 (coactivator-associated arginine methyltransferase). These results suggest that PRMT2 is a novel ERalpha coactivator. ..
  20. Vhuiyan M, Pak M, Park M, Thomas D, Lakowski T, Chalfant C, et al. PRMT2 interacts with splicing factors and regulates the alternative splicing of BCL-X. J Biochem. 2017;162:17-25 pubmed publisher
    ..These results indicate that active PRMT2 may play a role during inflammation in alternative splicing regulation. ..
  21. Zhong J, Cao R, Zu X, Hong T, Yang J, Liu L, et al. Identification and characterization of novel spliced variants of PRMT2 in breast carcinoma. FEBS J. 2012;279:316-35 pubmed publisher
    ..PRMT2 (also known as HRMT1L1) is clearly involved in lung function, the inflammatory response, apoptosis promotion, Wnt signaling and leptin ..
  22. Zhong J, Cao R, Liu J, Liu Y, Wang J, Liu L, et al. Nuclear loss of protein arginine N-methyltransferase 2 in breast carcinoma is associated with tumor grade and overexpression of cyclin D1 protein. Oncogene. 2014;33:5546-58 pubmed publisher
    Human protein arginine N-methyltransferase 2 (PRMT2, HRMT1L1) is a protein that belongs to the arginine methyltransferase family, and it has diverse roles in transcriptional regulation through different mechanisms depending on its ..