Gene Symbol: HRH2
Description: histamine receptor H2
Alias: H2R, histamine H2 receptor, HH2R, gastric receptor 1, gastric receptor I
Species: human
Products:     HRH2

Top Publications

  1. Hill S, Ganellin C, Timmerman H, Schwartz J, Shankley N, Young J, et al. International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacol Rev. 1997;49:253-78 pubmed
  2. Mancama D, Arranz M, Munro J, Osborne S, Makoff A, Collier D, et al. Investigation of promoter variants of the histamine 1 and 2 receptors in schizophrenia and clozapine response. Neurosci Lett. 2002;333:207-11 pubmed
  3. Liao R, Chen Y, Cheng L, Fan L, Chen H, Wan Y, et al. Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury. Stem Cell Reports. 2019;12:532-544 pubmed publisher
    ..stem cells is shown to be essential for this promotion by using Hrh1fl/fl;NestinCreERT2 and Hrh2fl/fl;NestinCreERT2 mice...
  4. Escobedo Ávila I, Vargas Romero F, Molina Hernández A, López González R, Cortés D, De Carlos J, et al. Histamine impairs midbrain dopaminergic development in vivo by activating histamine type 1 receptors. Mol Brain. 2014;7:58 pubmed publisher
    ..Cultured embryonic day 12 (E12) VM neural stem/progenitor cells expressed transcripts for HA receptors H1R, H2R and H3R. These undifferentiated progenitors increased intracellular calcium upon HA addition...
  5. García García M, Liarte S, Gómez González N, García Alcazar A, Pérez Sánchez J, Meseguer J, et al. Cimetidine disrupts the renewal of testicular cells and the steroidogenesis in a hermaphrodite fish. Comp Biochem Physiol C Toxicol Pharmacol. 2016;189:44-53 pubmed publisher
    ..We report here for the first time that histamine and the mRNA of Hrh1, Hrh2 and Hrh3 are all present in the gonad of the hermaphrodite teleost fish gilthead seabream...
  6. Jafarzadeh A, Nemati M, Khorramdelazad H, Hassan Z. Immunomodulatory properties of cimetidine: Its therapeutic potentials for treatment of immune-related diseases. Int Immunopharmacol. 2019;70:156-166 pubmed publisher
    ..Th17-, regulatory T-, CD8+ cytotoxic T cells, and B cells) through binding to histamine receptor 2 (H2R)...
  7. He C, Luo F, Chen X, Chen F, Li C, Ren S, et al. Superficial Layer-Specific Histaminergic Modulation of Medial Entorhinal Cortex Required for Spatial Learning. Cereb Cortex. 2016;26:1590-1608 pubmed publisher
    ..Furthermore, microinjection of the H1R or H3R, but not H2R, antagonist respectively into the superficial, but not deep, layers of MEC impairs rat spatial learning as assessed ..
  8. Lin L, Yamagata K, Nakayamada S, Sawamukai N, Yamaoka K, Sakata K, et al. Histamine inhibits differentiation of skin fibroblasts into myofibroblasts. Biochem Biophys Res Commun. 2015;463:434-9 pubmed publisher
    ..Histamine H1-receptor (H1R), but not H2-receptor (H2R) or H4-receptor (H4R), was expressed on skin fibroblasts at both mRNA and protein levels...
  9. Beermann S, Vauth M, Hein R, Seifert R, Neumann D. Distinct signalling pathways of murine histamine H1- and H4-receptors expressed at comparable levels in HEK293 cells. PLoS ONE. 2014;9:e107481 pubmed publisher recognized by its target cells via four G-protein-coupled receptors, referred to as histamine H1-receptor (H1R), H2R, H3R, and H4R. Both H1R and H4R exert pro-inflammatory functions...

More Information

Publications105 found, 100 shown here

  1. Costanza M, Di Dario M, Steinman L, Farina C, Pedotti R. Gene expression analysis of histamine receptors in peripheral blood mononuclear cells from individuals with clinically-isolated syndrome and different stages of multiple sclerosis. J Neuroimmunol. 2014;277:186-8 pubmed publisher
    ..In this study we analyzed the gene expression of histamine receptor 1 (HRH1), HRH2 and HRH4 in peripheral blood mononuclear cells derived from patients with clinically isolated syndrome (CIS), ..
  2. Sadek B, Saad A, Subramanian D, Shafiullah M, Łażewska D, Kieć Kononowiczc K. Anticonvulsant and procognitive properties of the non-imidazole histamine H3 receptor antagonist DL77 in male adult rats. Neuropharmacology. 2016;106:46-55 pubmed publisher
    ..effect of DL77 on retrieval was completely abrogated when rats were pretreated with the centrally-acting H2R antagonist zolantidine (ZOL) but not the centrally acting H1R antagonist PYR, indicating that histaminergic ..
  3. Femenía T, Magara S, DuPont C, Lindskog M. Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol. 2015;18: pubmed publisher
    ..Clobenpropit enhanced hippocampal plasticity, but did not affect EPSCs. H1R and H2R antagonists prevented the clobenpropit-induced increase in LTP and, injected locally into the hippocampus, blocked ..
  4. Potnuri A, Allakonda L, Appavoo A, Saheera S, Nair R. Association of histamine with hypertension-induced cardiac remodeling and reduction of hypertrophy with the histamine-2-receptor antagonist famotidine compared with the beta-blocker metoprolol. Hypertens Res. 2018;41:1023-1035 pubmed publisher
    ..hypertensive rats (SHRs) indicated a reduction of left ventricular hypertrophy (LVH) with a histamine-2-receptor (H2R) antagonist (famotidine)...
  5. Sun X, Li Y, Li W, Xu Z, Tang Y. Computational investigation of interactions between human H2 receptor and its agonists. J Mol Graph Model. 2011;29:693-701 pubmed publisher
    ..Residue Tyr250 could also form a hydrogen bond with H(2)R agonists. These findings would be very useful for the discovery of novel and potent H(2)R agonists. ..
  6. Werner K, Neumann D, Seifert R. Analysis of the histamine H2-receptor in human monocytes. Biochem Pharmacol. 2014;92:369-79 pubmed publisher
    Histamine receptors are G-protein-coupled receptors (GPCRs). Canonically, the histamine H2-receptor (H2R) couples to Gs-proteins and activates adenylyl cyclases (ACs) with subsequent adenosine-3',5'-cyclic monophosphate (cAMP) generation...
  7. Alachkar A, Latacz G, Siwek A, Lubelska A, Honkisz E, Gryboś A, et al. Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats. Pharmacol Biochem Behav. 2018;170:14-24 pubmed publisher
    ..when rats were co-injected with the brain penetrant H1R antagonist pyrilamine (PYR) but not the brain penetrant H2R antagonist zolantidine (ZOL)...
  8. del Rio R, Noubade R, Saligrama N, Wall E, Krementsov D, Poynter M, et al. Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system. J Immunol. 2012;188:541-7 pubmed publisher
    ..The pleiotropic effects of histamine are mediated by four G protein-coupled receptors, as follows: Hrh1/H(1)R, Hrh2/H(2)R, Hrh3/H(3)R, and Hrh4/H(4)R...
  9. Borriello F, Iannone R, Marone G. Histamine Release from Mast Cells and Basophils. Handb Exp Pharmacol. 2017;241:121-139 pubmed publisher
    ..cells and basophils exerts its biological activities by activating four G protein-coupled receptors, namely H1R, H2R, H3R (expressed mainly in the brain), and the recently identified H4R...
  10. Kishimoto Y, Asakawa S, Sato T, Takano T, Nakajyo T, Mizuno N, et al. Induced histamine regulates Ni elution from an implanted Ni wire in mice by downregulating neutrophil migration. Exp Dermatol. 2017;26:868-874 pubmed publisher
    ..MIP-2 expression was enhanced in histamine H2 receptor knockout (H2R KO) mice but not in WBB6F1-W/WV mice...
  11. Lancaster T, Ihssen I, Brindley L, Linden D. Preliminary evidence for genetic overlap between body mass index and striatal reward response. Transl Psychiatry. 2018;8:19 pubmed publisher
    ..BMI and VS BOLD were both significantly influenced by additive genetic factors (H2r = 0.57; 0.12, respectively)...
  12. Saligrama N, Case L, Krementsov D, Teuscher C. Histamine H? receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J. 2014;28:1898-909 pubmed publisher
    ..C57BL/6J (B6) mice deficient for the histamine H2 receptor (H2RKO) are less susceptible to EAE and exhibit blunted Th1 responses...
  13. Murakami M, Yoshikawa T, Nakamura T, Ohba T, Matsuzaki Y, Sawamura D, et al. Involvement of the histamine H1 receptor in the regulation of sympathetic nerve activity. Biochem Biophys Res Commun. 2015;458:584-589 pubmed publisher
    ..the superior cervical ganglion of H1R-null mice was higher than that in WT controls, whereas the enzyme levels in H2R- and H3R-null mice were not significantly different from those in the WT...
  14. Breunig E, Michel K, Zeller F, Seidl S, Weyhern C, Schemann M. Histamine excites neurones in the human submucous plexus through activation of H1, H2, H3 and H4 receptors. J Physiol. 2007;583:731-42 pubmed
    ..These data may form the basis of identification of new targets to treat inflammatory and functional gut disorders. ..
  15. Kagermeier N, Werner K, Keller M, Baumeister P, Bernhardt G, Seifert R, et al. Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. Bioorg Med Chem. 2015;23:3957-69 pubmed publisher
    The bioisosteric replacement of the acylguanidine moieties in dimeric histamine H2 receptor (H2R) agonists by carbamoylguanidine groups resulted in compounds with retained potencies and intrinsic activities, but considerably improved ..
  16. Lin X, Wang R, Zhang J, Sun X, Zou Z, Wang S, et al. Insights into Human Astrocyte Response to H5N1 Infection by Microarray Analysis. Viruses. 2015;7:2618-40 pubmed publisher
    ..related to the neuroactive ligand-receptor interaction pathway at 24 hpi, such as MC2R, CHRNG, P2RY13, GABRA1, and HRH2, which participant in synaptic transmission and may take part in CNS disorders induced by H5N1 infection...
  17. Xu J, Zhang X, Qian Q, Wang Y, Dong H, Li N, et al. Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes. J Neuroinflammation. 2018;15:41 pubmed publisher
    ..Astrocytes could constitutively express three histamine receptors (H1R, H2R, and H3R), and these three histamine receptors could be selectively upregulated to varying degrees upon histamine ..
  18. Merves J, Chandramouleeswaran P, Benitez A, Muir A, Lee A, Lim D, et al. Altered esophageal histamine receptor expression in Eosinophilic Esophagitis (EoE): implications on disease pathogenesis. PLoS ONE. 2015;10:e0114831 pubmed publisher
    ..Herein, we characterized HR (H1R, H2R, H3R, and H4R) expression in human esophageal biopsies and investigate the role of histamine signaling in inducible ..
  19. Mommert S, Kleiner S, Gehring M, Eiz Vesper B, Stark H, Gutzmer R, et al. Human basophil chemotaxis and activation are regulated via the histamine H4 receptor. Allergy. 2016;71:1264-73 pubmed publisher
    ..We could show that highly purified basophils express the H1R, H2R, and H4R but not the H3R mRNA...
  20. Khan N, Saad A, Nurulain S, Darras F, Decker M, Sadek B. The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats. Behav Brain Res. 2016;297:155-64 pubmed publisher
    ..completely reversed and partly abrogated in DIZ-induced amnesia when rats were pretreated with the centrally-acting H2R antagonist zolantidine (ZOL), but not with the CNS penetrant H1R antagonist pyrilamine (PYR)...
  21. Schaper K, Rossbach K, Köther B, Stark H, Kietzmann M, Werfel T, et al. Stimulation of the histamine 4 receptor upregulates thymic stromal lymphopoietin (TSLP) in human and murine keratinocytes. Pharmacol Res. 2016;113:209-215 pubmed publisher
    ..Experiments with different histamine receptor agonists (H1R: 2-pyridylethylamine; H2R: amthamine; H2R/H4R: 4-methylhistamine (4MH)) revealed a dominant role for the H4R receptor, as 4-MH in combination ..
  22. van Unen J, Rashidfarrokhi A, Hoogendoorn E, Postma M, Gadella T, Goedhart J. Quantitative Single-Cell Analysis of Signaling Pathways Activated Immediately Downstream of Histamine Receptor Subtypes. Mol Pharmacol. 2016;90:162-76 pubmed publisher
    ..The four histamine receptor subtypes (H1R, H2R, H3R, and H4R) respond to the ligand histamine by activating three canonical heterotrimeric G-protein-mediated ..
  23. Schenk H, Neumann D, Kloth C. Histamine regulates murine primary dendritic cell functions. Immunopharmacol Immunotoxicol. 2016;38:379-84 pubmed publisher
    ..receptor subtypes were determined by using the antagonists mepyramine (histamine H1-receptor: H1R), famotidine (H2R), and JNJ 7777120 (H4R)...
  24. Capelo R, Lehmann C, Ahmad K, Snodgrass R, Diehl O, Ringleb J, et al. Cellular analysis of the histamine H4 receptor in human myeloid cells. Biochem Pharmacol. 2016;103:74-84 pubmed publisher
    ..This was put into context with the expression of the H1R and H2R. In addition, the influence of various inflammatory stimuli on H4R expression was investigated in macrophages and ..
  25. Sadek B, Khan N, Darras F, Pockes S, Decker M. The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats. Physiol Behav. 2016;165:383-91 pubmed publisher
    ..25mg/kg, i.p.) in DIZ-induced amnesia was partly reversed when rats were pretreated with the centrally-acting H2R antagonist zolantidine (ZOL, 10mg/kg, i.p...
  26. Møller M, Kirkeby S, Vikeså J, Nielsen F, Caye Thomasen P. Expression of histamine receptors in the human endolymphatic sac: the molecular rationale for betahistine use in Menieres disease. Eur Arch Otorhinolaryngol. 2016;273:1705-10 pubmed publisher
    ..Receptors HRH2 and -4 were not expressed...
  27. Tanaka T, Kochi T, Shirakami Y, Mori T, Kurata A, Watanabe N, et al. Cimetidine and Clobenpropit Attenuate Inflammation-Associated Colorectal Carcinogenesis in Male ICR Mice. Cancers (Basel). 2016;8: pubmed publisher
    ..At week 18, feeding with the diets containing cimetidine (Hrh2 antagonist) and clobenpropit (Hrh3 antagonist/inverse agonist) significantly lowered the multiplicity of colonic ..
  28. Toubanaki D, Christopoulos T, Ioannou P, Flordellis C. High-throughput chemiluminometric genotyping of single nucleotide polymorphisms of histamine, serotonin, and adrenergic receptor genes. Anal Biochem. 2009;385:34-41 pubmed publisher
    ..a high-throughput method for genotyping of single nucleotide polymorphisms (SNPs) within the genes of histamine H2 receptor (HRH2), serotonin receptor (HTR2A1 and HTR2A2), and beta(3) adrenergic receptor (ADRB3)...
  29. Mommert S, Ratz L, Stark H, Gutzmer R, Werfel T. The histamine H4 receptor modulates the differentiation process of human monocyte-derived M1 macrophages and the release of CCL4/MIP-1? from fully differentiated M1 macrophages. Inflamm Res. 2018;67:503-513 pubmed publisher
    ..We demonstrated that monocytes and fully differentiated M1 macrophages express H1R-, H2R-, and H4R mRNA which were differentially regulated during the differentiation process and in IFN-? and LPS ..
  30. Gao C, Major A, Rendón D, Lugo M, Jackson V, Shi Z, et al. Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri. MBio. 2015;6:e01358-15 pubmed publisher
    ..gene(s) in the intestinal microbiome, consumption of a histidine-containing diet, and signaling via the histamine H2 receptor (H2R). Collectively, luminal conversion of l-histidine to histamine by hdc(+) L...
  31. Kang J, Lee Y, Kang M, Lee H, Oh R, Min H, et al. Synergistic mucus secretion by histamine and IL-4 through TMEM16A in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2017;313:L466-L476 pubmed publisher
    ..Histamine type 1 receptor (H1R) and histamine type 2 receptor (H2R) were not noted in SMG by in situ hybridization...
  32. Li J, Li X, He J, Wang J, Zhao M, Liang X, et al. Sex- and afferent-specific differences in histamine receptor expression in vagal afferents of rats: A potential mechanism for sexual dimorphism in prevalence and severity of asthma. Neuroscience. 2015;303:166-77 pubmed publisher
    ..Western-blot and SYBR green RT-PCR showed that H2R and H3R were highly expressed in NG of females compared with males and downregulated in ovariectomized females...
  33. Mondillo C, Varela M, Abiuso A, Vazquez R. Potential negative effects of anti-histamines on male reproductive function. Reproduction. 2018;155:R221-R227 pubmed publisher
    ..In this regard, HA receptors (HRH1, HRH2 and HRH4) have been described in Leydig cells of different species, including human...
  34. Panula P, Chazot P, Cowart M, Gutzmer R, Leurs R, Liu W, et al. International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev. 2015;67:601-55 pubmed publisher
    ..Its physiological functions are mediated by four 7-transmembrane G protein-coupled receptors (H1R, H2R, H3R, H4R) that are all targets of pharmacological intervention...
  35. Alonso N, Diaz Nebreda A, Monczor F, Gutkind J, Davio C, Fernandez N, et al. PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells. Biochim Biophys Acta. 2016;1860:1998-2007 pubmed publisher
    Histamine, through histamine H2 receptor (H2R), modulates different biological processes, involving the modulation of PI3K/AKT/mTOR and RAS/RAF/MEK/ERK pathways...
  36. Sadek B, Saad A, Latacz G, Kuder K, Olejarz A, Karcz T, et al. Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats. Drug Des Devel Ther. 2016;10:3879-3898 pubmed
    ..when rats were co-administered with the brain-penetrant H1R antagonist pyrilamine (PYR) but not the brain-penetrant H2R antagonist zolantidine (ZOL), demonstrating that histaminergic neurotransmission by activation of postsynaptically ..
  37. Nishi T, Koike T, Oka T, Maeda M, Futai M. Identification of the promoter region of the human histamine H2-receptor gene. Biochem Biophys Res Commun. 1995;210:616-23 pubmed
    The human histamine H2 receptor gene (a 13 kb 5'-upstream sequence, the 1,077 bp coding region and a 245 bp 3'-downstream sequence) was cloned and its 5'-upstream 1.8 kb nucleotide sequence was determined...
  38. Gutzmer R, Langer K, Lisewski M, Mommert S, Rieckborn D, Kapp A, et al. Expression and function of histamine receptors 1 and 2 on human monocyte-derived dendritic cells. J Allergy Clin Immunol. 2002;109:524-31 pubmed
    ..Expression of histamine H1 and H2 receptors (H1R and H2R) on MoDCs was assessed by means of RT-PCR and flow cytometry...
  39. Simonin F, Karcher P, Boeuf J, Matifas A, Kieffer B. Identification of a novel family of G protein-coupled receptor associated sorting proteins. J Neurochem. 2004;89:766-75 pubmed
    ..Another member of the family, GASP-2, also interacts with the carboxyl-terminal tail of several GPCRs. Therefore, GASP proteins may represent an important protein family regulating GPCR physiology. ..
  40. Frei R, Ferstl R, Konieczna P, Ziegler M, Simon T, Rugeles T, et al. Histamine receptor 2 modifies dendritic cell responses to microbial ligands. J Allergy Clin Immunol. 2013;132:194-204 pubmed publisher
    ..The induction of tolerance and protective immunity to microbes is significantly influenced by host- and microbiota-derived metabolites, such as histamine...
  41. Vašíček O, Lojek A, Jancinova V, Nosal R, Ciz M. Role of histamine receptors in the effects of histamine on the production of reactive oxygen species by whole blood phagocytes. Life Sci. 2014;100:67-72 pubmed publisher
    ..In this study we investigated the role of H2R and H4R in the effects of histamine on the production of reactive oxygen species by phagocytes in whole blood...
  42. Orange P, Heath P, Wright S, Pearson R. Allelic variations of the human histamine H2 receptor gene. Neuroreport. 1996;7:1293-6 pubmed
    The gene encoding the human histamine H2 receptor (H2R) has previously been cloned and sequenced from gastric cDNA...
  43. Del Valle J, Gantz I. Novel insights into histamine H2 receptor biology. Am J Physiol. 1997;273:G987-96 pubmed
    ..The novel observation that histamine may stimulate c-fos gene expression lends further support to the possible role of this receptor in regulating cell growth and differentiation. ..
  44. Elenkov I, Webster E, Papanicolaou D, Fleisher T, Chrousos G, Wilder R. Histamine potently suppresses human IL-12 and stimulates IL-10 production via H2 receptors. J Immunol. 1998;161:2586-93 pubmed
  45. Hegyesi H, Horváth B, Pallinger E, Pos Z, Molnar V, Falus A. Histamine elevates the expression of Ets-1, a protooncogen in human melanoma cell lines through H2 receptor. FEBS Lett. 2005;579:2475-9 pubmed
    ..and clinical data suggest that histamine augments in vivo tumour cell proliferation via histamine H2 receptors (H2R)...
  46. Tetlow L, Woolley D. Demonstration of histamine H1 and H2 receptors in chondrocytes of human osteoarthritic cartilage. Inflamm Res. 2005;54 Suppl 1:S74-5 pubmed
  47. McCord J, Halliwill J. H1 and H2 receptors mediate postexercise hyperemia in sedentary and endurance exercise-trained men and women. J Appl Physiol (1985). 2006;101:1693-701 pubmed
    ..control day). These data suggest postexercise skeletal muscle hyperemia exists in endurance trained men and women. Furthermore, histaminergic mechanisms produce the long-lasting hyperemia in sedentary and endurance-trained individuals. ..
  48. Akdis C, Jutel M, Akdis M. Regulatory effects of histamine and histamine receptor expression in human allergic immune responses. Chem Immunol Allergy. 2008;94:67-82 pubmed publisher
    ..In addition, differences in affinities of these receptors for histamine are highly decisive for the biological effects of histamine and drugs that target histamine receptors. ..
  49. Nomura T, Tahara T, Shiroeda H, Minato T, Matsue Y, Hayashi R, et al. Influence of HRH2 promoter polymorphism on aberrant DNA methylation of DAPK and CDH1 in the gastric epithelium. BMC Gastroenterol. 2013;13:1 pubmed publisher
    ..We report an investigation into the effect of HRH2 promoter polymorphism (rs2607474 G > A) on the methylation of DAPK and CDH1...
  50. Taati M, Moghaddasi M, Esmaeili M, Pourkhodadad S, Nayebzadeh H. The role of the central histaminergic receptors in the exercise-induced improvements of the spatial learning and memory in rats. Brain Res. 2014;1587:112-8 pubmed publisher
    ..Our findings indicate that central histamine H2 receptors play an important role in mediating the beneficial effects of forced exercise on learning and memory. ..
  51. Liu X, Kumagai G, Wada K, Tanaka T, Fujita T, Sasaki A, et al. Suppression of osteogenic differentiation in mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament by a histamine-2-receptor antagonist. Eur J Pharmacol. 2017;810:156-162 pubmed publisher
    ..Histamine receptor H2 (H2R) antagonists (H2 blockers) like famotidine decrease ossification in patients, by an unclear mechanism...
  52. Vannier E, Dinarello C. Histamine enhances interleukin (IL)-1-induced IL-6 gene expression and protein synthesis via H2 receptors in peripheral blood mononuclear cells. J Biol Chem. 1994;269:9952-6 pubmed
    ..5 h versus 1.8 h). Our results indicate that cAMP-increasing agents, such as histamine or prostaglandin E2, fail to induce IL-6 synthesis but rather enhance IL-1-induced IL-6 synthesis. ..
  53. Smit M, Timmerman H, Alewijnse A, Punin M, van den Nieuwenhof I, Blauw J, et al. Visualization of agonist-induced internalization of histamine H2 receptors. Biochem Biophys Res Commun. 1995;214:1138-45 pubmed
    ..Forskolin did not induce H2 receptor internalization, indicating that histamine causes H2 receptor internalization via a cAMP-independent pathway. ..
  54. Choi J, Kim S, Suh C, Nahm D, Park H. Polymorphisms of high-affinity IgE receptor and histamine-related genes in patients with ASA-induced urticaria/angioedema. J Korean Med Sci. 2005;20:367-72 pubmed
    ..and three histamine-related genes-histamine N-methyltransferase (HNMT), histamine H1 receptor (HRH1), histamine H2 receptor (HRH2)-were screened using the SNP-IT assay based on a single base extension method...
  55. Cianchi F, Cortesini C, Schiavone N, Perna F, Magnelli L, Fanti E, et al. The role of cyclooxygenase-2 in mediating the effects of histamine on cell proliferation and vascular endothelial growth factor production in colorectal cancer. Clin Cancer Res. 2005;11:6807-15 pubmed
    ..These effects are likely to be mediated by increasing COX-2-related PGE2 production in COX-2-expressing colon cancer cells. ..
  56. Ujike H, Nomura A, Morita Y, Morio A, Okahisa Y, Kotaka T, et al. Multiple genetic factors in olanzapine-induced weight gain in schizophrenia patients: a cohort study. J Clin Psychiatry. 2008;69:1416-22 pubmed
  57. Arisawa T, Tahara T, Ozaki K, Matsue Y, Minato T, Yamada H, et al. Association between common genetic variant of HRH2 and gastric cancer risk. Int J Oncol. 2012;41:497-503 pubmed publisher
    ..element of the promoter and non-synonymous rs79385261 (Asn46Thr) were identified in HRH2. We attempted to clarify the associations of these polymorphisms with gastric carcinogenesis...
  58. Yamada H, Tahara T, Shiroeda H, Hayashi R, Saito T, Nakamura M, et al. Effects of -1018G>A polymorphism of HRH2 (rs2607474) on the severity of gastric mucosal atrophy. J Gastrointestin Liver Dis. 2012;21:139-43 pubmed
    ..A polymorphism -1018 G>A (rs2067474) was identified in an enhancer element of the HRH2 promoter...
  59. Lee H, Park M, Lee E, Kim Y, Kim H, Kang J, et al. Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. Int J Biochem Cell Biol. 2012;44:2124-8 pubmed publisher
  60. Ciebiada M, Kasztalska K, Gorska Ciebiada M, Górski P. Histamine type 2 receptor expression on peripheral blood regulatory lymphocytes in patients with allergic rhinitis treated with specific immunotherapy. Am J Rhinol Allergy. 2014;28:e130-5 pubmed publisher
    Both histamine H1- and H2-receptors (H2R) were found on regulatory T (Treg) cells; however, there is a paucity of information regarding the role of H2R in Treg function...
  61. Romero S, Ely M, Sieck D, Luttrell M, Buck T, Kono J, et al. Effect of antioxidants on histamine receptor activation and sustained postexercise vasodilatation in humans. Exp Physiol. 2015;100:435-49 pubmed publisher
    ..Overall, exercise-induced oxidative stress does not appear to contribute to sustained postexercise vasodilatation. ..
  62. Naganuma F, Nakamura T, Yoshikawa T, Iida T, Miura Y, Kárpáti A, et al. Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Sci Rep. 2017;7:15899 pubmed publisher
    ..High aggression in KO mice was suppressed by treatment with zolantidine, a histamine H2 receptor (H2R) antagonist, indicating that abnormal H2R activation promoted aggression in KO mice...
  63. Leary P, Kronmal R, Bluemke D, Buttrick P, Jones K, Kao D, et al. Histamine H2 Receptor Polymorphisms, Myocardial Transcripts, and Heart Failure (from the Multi-Ethnic Study of Atherosclerosis and Beta-Blocker Effect on Remodeling and Gene Expression Trial). Am J Cardiol. 2018;121:256-261 pubmed publisher
    ..This study evaluated whether H2 histamine receptor (HRH2) single nucleotide polymorphisms (SNPs) are associated with HF incidence and whether myocardial transcript ..
  64. Murakami H, Sun Wada G, Matsumoto M, Nishi T, Wada Y, Futai M. Human histamine H2 receptor gene: multiple transcription initiation and tissue-specific expression. FEBS Lett. 1999;451:327-31 pubmed
    We have characterized the genomic structure of 12.3 kb of the 5'-flanking region of the human histamine H2 receptor gene...
  65. Esbenshade T, Kang C, Krueger K, Miller T, Witte D, Roch J, et al. Differential activation of dual signaling responses by human H1 and H2 histamine receptors. J Recept Signal Transduct Res. 2003;23:17-31 pubmed
    ..86 and 4.82, respectively). These studies demonstrate a markedly different potency for activation of multiple signaling pathways by H1- and H2-HRs that may contribute to the selectivity of histamine responses in vivo. ..
  66. Osawa S, Kajimura M, Yamamoto S, Ikuma M, Mochizuki C, Iwasaki H, et al. Alteration of intracellular histamine H2 receptor cycling precedes antagonist-induced upregulation. Am J Physiol Gastrointest Liver Physiol. 2005;289:G880-9 pubmed
    Long-term administration of a histamine H2 receptor (H2R) antagonist (inverse agonist) induces upregulation of H2R in parietal cells, which may be relevant to the rebound hypersecretion of gastric acid that occurs after withdrawal of ..
  67. Boer K, Helinger E, Helinger A, Pocza P, Pos Z, Demeter P, et al. Decreased expression of histamine H1 and H4 receptors suggests disturbance of local regulation in human colorectal tumours by histamine. Eur J Cell Biol. 2008;87:227-36 pubmed publisher
    ..001) H1R and H4R mRNA levels in tumours compared to normal colonic mucosa, without any significant change in H2R mRNA expression. H3R was absent in most samples; it was detected at low levels in 7.9% of the cases...
  68. Fernandez N, Monczor F, Baldi A, Davio C, Shayo C. Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization. Mol Pharmacol. 2008;74:1109-18 pubmed publisher
    ..In the present study, we sought to establish whether the histamine H2 receptor (H2r) agonist amthamine, besides promoting receptor desensitization, induced H2r internalization...
  69. Szukiewicz D, Pyzlak M, Stangret A, Rongies W, Maslinska D. Decrease in expression of histamine H2 receptors by human amniotic epithelial cells during differentiation into pancreatic beta-like cells. Inflamm Res. 2010;59 Suppl 2:S205-7 pubmed publisher
    ..73 +/- 11.03 of the reference value obtained in control HAEC. Variable expression of H(2) during nicotinamide-induced differentiation of HAEC into PBLC may define a time-point, indicating involvement of histamine at the earlier stages. ..
  70. Qin Y, Ma S, Zhuang Q, Qiu Y, Li B, Peng Y, et al. Histamine evokes excitatory response of neurons in the cerebellar dentate nucleus via H2 receptors. Neurosci Lett. 2011;502:133-7 pubmed publisher
  71. Cai W, Zhang J, Wang N, Wang Y, Zhao C, Lu J, et al. Lack of Association between rs2067474 Polymorphism in Histamine Receptor H2 Gene and Breast Cancer in Chinese Han Population. ScientificWorldJournal. 2015;2015:545292 pubmed publisher
    b>Histamine H2 receptor (HRH2) was previously suggested to affect the proliferation of breast cancer cells and disease-free survival of breast cancer patients...
  72. He G, Cai W, Zhang J, Ma C, Yan F, Lu J, et al. Associations of Polymorphisms in HRH2, HRH3, DAO, and HNMT Genes with Risk of Chronic Heart Failure. Biomed Res Int. 2016;2016:1208476 pubmed publisher
    ..However, the relevance of polymorphisms in histamine-related genes, such as HRH2, HRH3, DAO, and HNMT, with CHF remains largely neglected...
  73. Jiang Y, Li H, Wang Y, Tian T, He Y, Jin Y, et al. ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncol Lett. 2017;14:6955-6961 pubmed publisher
    ..The enzyme activity of ALDH was upregulated by histamine and agonists of histamine H1 receptor (H1R) and histamine H2 receptor (H2R)...
  74. Gantz I, Munzert G, Tashiro T, Schaffer M, Wang L, Delvalle J, et al. Molecular cloning of the human histamine H2 receptor. Biochem Biophys Res Commun. 1991;178:1386-92 pubmed
    ..These data confirm that we have successfully cloned a novel gene encoding the human H2 histamine receptor. ..
  75. Suh B, Lee H, Jun D, Chun J, Lee J, Kim K. Inhibition of H2 histamine receptor-mediated cation channel opening by protein kinase C in human promyelocytic cells. J Immunol. 2001;167:1663-71 pubmed
    ..Both effects of histamine were selectively inhibited probably by the delta isoform of PKC in HL-60 cells. ..
  76. Brew O, Sullivan M. Localisation of mRNAs for diamine oxidase and histamine receptors H1 and H2, at the feto-maternal interface of human pregnancy. Inflamm Res. 2001;50:449-52 pubmed
    ..The co-expression of these receptors and DAO is consistent with a role for histamine at the feto-maternal interface of human pregnancy. ..
  77. Delgado M, Fuentes J, Fernández Alfonso M. Histamine up-regulates phosphodiesterase IV activity in U-937 cells through H2 receptor stimulation and cAMP increase. Med Sci Monit. 2003;9:BR212-9 pubmed
    ..AMPc enhancement of the cyclic nucleotide levels may trigger expression and synthesis of this enzyme. ..
  78. Albrecht M, Frungieri M, Gonzalez Calvar S, Meineke V, Köhn F, Mayerhofer A. Evidence for a histaminergic system in the human testis. Fertil Steril. 2005;83:1060-3 pubmed
  79. Preuss H, Ghorai P, Kraus A, Dove S, Buschauer A, Seifert R. Mutations of Cys-17 and Ala-271 in the human histamine H2 receptor determine the species selectivity of guanidine-type agonists and increase constitutive activity. J Pharmacol Exp Ther. 2007;321:975-82 pubmed
    ..Distinct potencies and efficacies of agonists and inverse agonists further support the concept of ligand-specific conformations in wild-type and mutant H(2)R-G(salphaS) fusion proteins. ..
  80. Xu A, Kuramasu A, Maeda K, Kinoshita K, Takayanagi S, Fukushima Y, et al. Agonist-induced internalization of histamine H2 receptor and activation of extracellular signal-regulated kinases are dynamin-dependent. J Neurochem. 2008;107:208-17 pubmed publisher
    b>Histamine H2 receptor (H2R) is a member of G protein-coupled receptor family...
  81. Fernandez T, Sanders S, Yurkiewicz I, Ercan Sencicek A, Kim Y, Fishman D, et al. Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biol Psychiatry. 2012;71:392-402 pubmed publisher
  82. Alachkar A, Łazewska D, Kiec Kononowicz K, Sadek B. The Histamine H3 Receptor Antagonist E159 Reverses Memory Deficits Induced by Dizocilpine in Passive Avoidance and Novel Object Recognition Paradigm in Rats. Front Pharmacol. 2017;8:709 pubmed publisher DIZ-induced amnesic model were moderately abrogated after acute systemic administration of scopolamine (SCO), H2R antagonist zolantidine (ZOL), but not with H1R antagonist pyrilamine to the animals...
  83. Wang L, Wang M, Todisco A, Grand E, Del Valle J. The human histamine H(2) receptor regulates c-jun and c-fos in a differential manner. Am J Physiol Cell Physiol. 2000;278:C1246-55 pubmed
    ..Our findings suggest that histamine stimulates both c-fos and c-jun mRNA in a differential manner. PKC is involved in histamine-mediated c-fos activation, whereas p70 S6 kinase is important for linkage of this receptor to c-jun...
  84. Schaefer U, Schneider A, Rudroff C, Neugebauer E. Nitric oxide mediates histamine induced down-regulation of H2 receptor mRNA and internalization of the receptor protein (R1). Cell Mol Life Sci. 2003;60:1968-81 pubmed
    ..Based on our recently reported results showing an H1-mediated down-regulation of histamine H2 receptor mRNA in endothelial cells, our aim was to characterize the mechanism controlling rapid and long-term ..
  85. Fernandez N, Gottardo F, Alonso M, Monczor F, Shayo C, Davio C. Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2. J Biol Chem. 2011;286:28697-706 pubmed publisher
    ..In the present study we investigated whether the histamine H2 receptor (H2R), a G?(s)-coupled GPCR known to be desensitized by GRK2, needs to be phosphorylated for its ..
  86. Hu W, Chen Z. Role of histamine and its receptors in cerebral ischemia. ACS Chem Neurosci. 2012;3:238-47 pubmed publisher
    ..However, important questions about the molecular aspects and pathophysiology of histamine and related agents in cerebral ischemia remain to be answered to form a solid scientific basis for therapeutic application. ..
  87. Naddafi F, Mirshafiey A. The neglected role of histamine in Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2013;28:327-36 pubmed publisher
    ..But recent studies show that histamine antagonists against H3R and regulation of H2R can be more efficient in AD therapy...
  88. Ayuso P, Blanca M, Cornejo García J, Torres M, Doña I, Salas M, et al. Variability in histamine receptor genes HRH1, HRH2 and HRH4 in patients with hypersensitivity to NSAIDs. Pharmacogenomics. 2013;14:1871-8 pubmed publisher
    ..The authors analyzed copy number variations (CNVs) and common functional SNPs in genes HRH1, HRH2 and HRH4 in 442 unrelated patients with hypersensitivity to NSAIDs and in 414 healthy unrelated controls...
  89. Werner K, Neumann D, Seifert R. High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor. Naunyn Schmiedebergs Arch Pharmacol. 2016;389:87-101 pubmed
    ..Its antileukemic activity is related to histamine H2-receptor (H2R)-mediated inhibition of reactive oxygen species (ROS) production in myeloid cells facilitating survival of ..
  90. Traiffort E, Vizuete M, Tardivel Lacombe J, Souil E, Schwartz J, Ruat M. The guinea pig histamine H2 receptor: gene cloning, tissue expression and chromosomal localization of its human counterpart. Biochem Biophys Res Commun. 1995;211:570-7 pubmed
    The guinea pig is the prototypic animal species for the histamine H2 receptor. Using a strategy based upon nucleotide sequence homology and starting from the sequence of the rat histamine H2 receptor (Ruat et al., Biochem. Biophys. Res...
  91. Shayo C, Fernandez N, Legnazzi B, Monczor F, Mladovan A, Baldi A, et al. Histamine H2 receptor desensitization: involvement of a select array of G protein-coupled receptor kinases. Mol Pharmacol. 2001;60:1049-56 pubmed
    The histamine H2 receptor (H2r) belongs to the heptahelical receptor family; upon agonist binding, members of this family activate a G protein and the downstream effector adenylyl cyclase...
  92. Tanimoto A, Murata Y, Nomaguchi M, Kimura S, Arima N, Xu H, et al. Histamine increases the expression of LOX-1 via H2 receptor in human monocytic THP-1 cells. FEBS Lett. 2001;508:345-9 pubmed
    ..This histamine effect on LOX-1 gene expression, via the histamine H2 receptor-mediated cAMP signal transduction pathway, was reduced after differentiation of the cells into macrophages,..