Genomes and Genes
Gene Symbol: HPIV3gp4
Description: C protein
Species: Human parainfluenza virus 3
- Genetic characterization of parainfluenza virus 3 derived from guinea pigsK Ohsawa
Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine, Japan
J Vet Med Sci 60:919-22. 1998..The results of the phylogenetic analysis clearly showed that GPv is a lineage of human PIV-3, suggesting that GPv has probably been introduced into guinea pig colonies via infected humans...
- Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primatesA P Durbin
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Virology 261:319-30. 1999..These results indicate that the C, D, and V proteins of HPIV3 each has a role in virus replication in vitro, in vivo, or both, and define mutations that might be useful for the development of a vaccine against HPIV3...
- Inhibition of STAT 1 phosphorylation by human parainfluenza virus type 3 C proteinAchut G Malur
Cleveland Clinic Foundation, Section Virology NN 10, Department of Molecular Biology, 9500 Euclid Avenue, Cleveland, OH 44195 5178, USA
J Virol 79:7877-82. 2005..Taken together, our results indicate that HPIV 3 C protein is capable of counteracting the interferon signaling pathway by specifically inhibiting the activation of STAT 1...
- Evidence for phosphorylation of human parainfluenza virus type 3 C protein: mutant C proteins exhibit variable inhibitory activities in vitroAchut G Malur
Department of Microbiology and Immunology, Brody School of Medicine, Biotech 124, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA
Virus Res 144:180-7. 2009..Taken together, our results indicate that phosphorylation may differentially affect the inhibitory activity of C protein thereby regulating viral RNA synthesis...
- Domain within the C protein of human parainfluenza virus type 3 that regulates interferon signalingHongxia Mao
Virology Section, Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Gene Expr 15:43-50. 2010..Furthermore, our results indicate that the charged amino acid residues within the N-terminal region of the C protein regulate the antagonistic effect of the C protein on IFN signaling...