HPIV3gp4

Summary

Gene Symbol: HPIV3gp4
Description: C protein
Species: Human parainfluenza virus 3

Top Publications

  1. ncbi Genetic characterization of parainfluenza virus 3 derived from guinea pigs
    K Ohsawa
    Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine, Japan
    J Vet Med Sci 60:919-22. 1998
  2. ncbi Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates
    A P Durbin
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 261:319-30. 1999
  3. ncbi Inhibition of STAT 1 phosphorylation by human parainfluenza virus type 3 C protein
    Achut G Malur
    Cleveland Clinic Foundation, Section Virology NN 10, Department of Molecular Biology, 9500 Euclid Avenue, Cleveland, OH 44195 5178, USA
    J Virol 79:7877-82. 2005
  4. ncbi Evidence for phosphorylation of human parainfluenza virus type 3 C protein: mutant C proteins exhibit variable inhibitory activities in vitro
    Achut G Malur
    Department of Microbiology and Immunology, Brody School of Medicine, Biotech 124, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA
    Virus Res 144:180-7. 2009
  5. ncbi Domain within the C protein of human parainfluenza virus type 3 that regulates interferon signaling
    Hongxia Mao
    Virology Section, Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Gene Expr 15:43-50. 2010

Scientific Experts

  • A P Durbin
  • Achut G Malur
  • Hongxia Mao
  • Santanu Chattopadhyay
  • Amiya K Banerjee
  • K Ohsawa
  • A Yamada
  • H Sato
  • H Miyata
  • Y Watanabe
  • K Takeuchi

Detail Information

Publications5

  1. ncbi Genetic characterization of parainfluenza virus 3 derived from guinea pigs
    K Ohsawa
    Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine, Japan
    J Vet Med Sci 60:919-22. 1998
    ..The results of the phylogenetic analysis clearly showed that GPv is a lineage of human PIV-3, suggesting that GPv has probably been introduced into guinea pig colonies via infected humans...
  2. ncbi Mutations in the C, D, and V open reading frames of human parainfluenza virus type 3 attenuate replication in rodents and primates
    A P Durbin
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 261:319-30. 1999
    ..These results indicate that the C, D, and V proteins of HPIV3 each has a role in virus replication in vitro, in vivo, or both, and define mutations that might be useful for the development of a vaccine against HPIV3...
  3. ncbi Inhibition of STAT 1 phosphorylation by human parainfluenza virus type 3 C protein
    Achut G Malur
    Cleveland Clinic Foundation, Section Virology NN 10, Department of Molecular Biology, 9500 Euclid Avenue, Cleveland, OH 44195 5178, USA
    J Virol 79:7877-82. 2005
    ..Taken together, our results indicate that HPIV 3 C protein is capable of counteracting the interferon signaling pathway by specifically inhibiting the activation of STAT 1...
  4. ncbi Evidence for phosphorylation of human parainfluenza virus type 3 C protein: mutant C proteins exhibit variable inhibitory activities in vitro
    Achut G Malur
    Department of Microbiology and Immunology, Brody School of Medicine, Biotech 124, East Carolina University, 600 Moye Boulevard, Greenville, NC 27834, USA
    Virus Res 144:180-7. 2009
    ..Taken together, our results indicate that phosphorylation may differentially affect the inhibitory activity of C protein thereby regulating viral RNA synthesis...
  5. ncbi Domain within the C protein of human parainfluenza virus type 3 that regulates interferon signaling
    Hongxia Mao
    Virology Section, Department of Molecular Genetics, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Gene Expr 15:43-50. 2010
    ..Furthermore, our results indicate that the charged amino acid residues within the N-terminal region of the C protein regulate the antagonistic effect of the C protein on IFN signaling...