Gene Symbol: HOXD10
Description: homeobox D10
Alias: HOX4, HOX4D, HOX4E, Hox-4.4, homeobox protein Hox-D10, homeo box 4D, homeo box D10, homeobox protein Hox-4D, homeobox protein Hox-4E
Species: human
Products:     HOXD10

Top Publications

  1. Tabin C. Why we have (only) five fingers per hand: hox genes and the evolution of paired limbs. Development. 1992;116:289-96 pubmed
    ..The expression patterns of Hox genes in modern embryonic limb buds also gives clues to the shape of the ancestral fin field from which the limb evolved, hence elucidating the evolution of the tetrapod limb. ..
  2. Goodman F, Majewski F, Collins A, Scambler P. A 117-kb microdeletion removing HOXD9-HOXD13 and EVX2 causes synpolydactyly. Am J Hum Genet. 2002;70:547-55 pubmed
    ..They also suggest that there is a regulatory region, upstream of the HOXD cluster, that is responsible for activating the cluster as a whole...
  3. Myers C, Charboneau A, Cheung I, Hanks D, Boudreau N. Sustained expression of homeobox D10 inhibits angiogenesis. Am J Pathol. 2002;161:2099-109 pubmed
    ..b>HoxD10 expression was higher in quiescent as compared to tumor-associated angiogenic endothelium...
  4. Nakayama I, Shibazaki M, Yashima Abo A, Miura F, Sugiyama T, Masuda T, et al. Loss of HOXD10 expression induced by upregulation of miR-10b accelerates the migration and invasion activities of ovarian cancer cells. Int J Oncol. 2013;43:63-71 pubmed publisher
    ..miRNA?10b (miR-10b) and homemobox (HOX) transcript antisense RNA (HOTAIR), can suppress the translation of the HOXD10 gene, an mRNA encoding a transcriptional repressor that inhibits the expression of cell migration/invasion-..
  5. Liu Z, Zhu J, Cao H, Ren H, Fang X. miR-10b promotes cell invasion through RhoC-AKT signaling pathway by targeting HOXD10 in gastric cancer. Int J Oncol. 2012;40:1553-60 pubmed publisher
    ..function as a metastasis driver in different types of cancer, in which the downstream target gene HOXD10 is the main mediator...
  6. Wang L, Chen S, Xue M, Zhong J, Wang X, Gan L, et al. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Mol Med. 2012;18:389-400 pubmed publisher
    Homeobox D10 (HoxD10 ) gene plays a critical role in cell differentiation and morphogenesis during development. However, the function of HoxD10 in tumor progression remains largely unknown...
  7. Sun L, Yan W, Wang Y, Sun G, Luo H, Zhang J, et al. MicroRNA-10b induces glioma cell invasion by modulating MMP-14 and uPAR expression via HOXD10. Brain Res. 2011;1389:9-18 pubmed publisher
    ..induced glioma cell invasion by modulating tumor invasion factors MMP-14 and uPAR expression via the direct target HOXD10. The miR-10b/HOXD10/MMP-14/uPAR signaling pathway might contribute to the invasion of glioma...
  8. Carrio M, Arderiu G, Myers C, Boudreau N. Homeobox D10 induces phenotypic reversion of breast tumor cells in a three-dimensional culture model. Cancer Res. 2005;65:7177-85 pubmed
    ..We previously reported that HoxD10 helps to maintain a quiescent, differentiated phenotype in endothelial cells by suppressing expression of genes ..
  9. Zhang Q, Ran R, Zhang L, Liu Y, Mei L, Zhang Z, et al. Simultaneous delivery of therapeutic antagomirs with paclitaxel for the management of metastatic tumors by a pH-responsive anti-microbial peptide-mediated liposomal delivery system. J Control Release. 2015;197:208-18 pubmed publisher
    ..prominently delay the growth of 4T1 tumors and reduce the lung metastases at the same time, and the expression of Hoxd10 in tumors was also significantly up-regulated...

More Information


  1. Yuan Y, Wang H, Lai Y, Zhong W, Liang W, Yan F, et al. Epigenetic inactivation of HOXD10 is associated with human colon cancer via inhibiting the RHOC/AKT/MAPK signaling pathway. Cell Commun Signal. 2019;17:9 pubmed publisher
    To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway. Thirty-seven paired colon cancer and its adjacent samples from The Cancer Genome Atlas (TCGA) were analyzed...
  2. Liao C, Kong L, Zhou P, Yang X, Huang J, Zhang H, et al. miR-10b is overexpressed in hepatocellular carcinoma and promotes cell proliferation, migration and invasion through RhoC, uPAR and MMPs. J Transl Med. 2014;12:234 pubmed publisher
    ..We also showed that HOXD10 was negatively regulated by miR-10b at the posttranscriptional level, via a specific target site within the 3'UTR ..
  3. Kulakova M, Bakalenko N, Novikova E. Early mesodermal expression of Hox genes in the polychaete Alitta virens (Annelida, Lophotrochozoa). Dev Genes Evol. 2017;227:69-74 pubmed publisher
    ..show that three Hox genes of the polychaete Alitta virens (formerly Nereis virens, Annelida, Lophotrochozoa)-Hox2, Hox4, and Lox5-are expressed in the mesodermal anlagen of the three future larval chaetigerous segments in spatially ..
  4. Wang Y, Li Z, Zhao X, Zuo X, Zhang Y, Xiao Y, et al. MicroRNA-10b is upregulated and has an invasive role in colorectal cancer through enhanced Rhoc expression. Oncol Rep. 2015;33:1275-83 pubmed publisher
    ..compared with those in lymph node metastasis-free tumor tissue, and were correlated with a downregulation in Hoxd10 expression...
  5. Wang C, Zou H, Feng G. MiR-10b regulates the proliferation and apoptosis of pediatric acute myeloid leukemia through targeting HOXD10. Eur Rev Med Pharmacol Sci. 2018;22:7371-7378 pubmed publisher
    ..The interaction between miR-10b and homeobox D10 (HOXD10) was confirmed by qRT-PCR, Western blotting and Luciferase assay...
  6. Prin F, Serpente P, Itasaki N, Gould A. Hox proteins drive cell segregation and non-autonomous apical remodelling during hindbrain segmentation. Development. 2014;141:1492-502 pubmed publisher
    ..b>Hox4 proteins regulate Eph/ephrins and other cell-surface proteins, and can function in a non-cell-autonomous manner to ..
  7. Joo M, Park J, Chun H. Impact of homeobox genes in gastrointestinal cancer. World J Gastroenterol. 2016;22:8247-8256 pubmed
    ..b>HOXD10 is upregulated in colorectal cancer while it is silenced epigenetically in gastric cancer...
  8. Bu P, Wang L, Chen K, Rakhilin N, Sun J, Closa A, et al. miR-1269 promotes metastasis and forms a positive feedback loop with TGF-β. Nat Commun. 2015;6:6879 pubmed publisher
    ..TGF-β activates miR-1269 via Sox4, while miR-1269a enhances TGF-β signalling by targeting Smad7 and HOXD10, hence forming a positive feedback loop...
  9. Zheng L, Zhang Z, Zhang S, Guo Q, Zhang F, Gao L, et al. RNA Binding Protein RNPC1 Inhibits Breast Cancer Cell Metastasis via Activating STARD13-Correlated ceRNA Network. Mol Pharm. 2018;15:2123-2132 pubmed publisher
    ..Mechanistically, RNPC1 promotes competing endogenous RNA (ceRNA) network crosstalk among STARD13, CDH5, HOXD10, and HOXD1 (STARD13-correlated ceRNA network), which we previously confirmed in breast cancer cells through ..
  10. Singh R, Pochampally R, Watabe K, Lu Z, Mo Y. Exosome-mediated transfer of miR-10b promotes cell invasion in breast cancer. Mol Cancer. 2014;13:256 pubmed publisher
    ..Moreover, upon uptake, miR-10b can suppress the protein level of its target genes such as HOXD10 and KLF4, indicating its functional significance...
  11. Hueber S, Frickey T. Solving Classification Problems for Large Sets of Protein Sequences with the Example of Hox and ParaHox Proteins. J Dev Biol. 2016;4: pubmed publisher
    ..The overall sequence-similarities show Gsx to be most similar to Hox2-3, and Cdx to be most similar to Hox4-8...
  12. Chen C, Ko T, Chang T, Chern S, Chen S, Lai S, et al. Prenatal diagnosis of short-rib polydactyly syndrome type III or short-rib thoracic dysplasia 3 with or without polydactyly (SRTD3) associated with compound heterozygous mutations in DYNC2H1 in a fetus. Taiwan J Obstet Gynecol. 2018;57:123-127 pubmed publisher
    ..NGS) was applied to analyze a panel of 25 genes including CEP120, DYNC2H1, DYNC2LI1, EVC, EVC2, FGFR2, FGFR3, HOXD10, IFT122, IFT140, IFT172, IFT52, IFT80, KIAA0586, NEK1, PAPSS2, SLC26A2, SOX9, TCTEX1D2, TCTN3, TTC21B, WDR19, ..
  13. Heubach J, Monsior J, Deenen R, Niegisch G, Szarvas T, Niedworok C, et al. The long noncoding RNA HOTAIR has tissue and cell type-dependent effects on HOX gene expression and phenotype of urothelial cancer cells. Mol Cancer. 2015;14:108 pubmed publisher
    ..an aggressive phenotype in many cancers and aberrant expression of homeotic HOX transcription factors, especially HOXD10, that regulate differentiation and tissue homeostasis...
  14. Matsubara H, Saito D, Abe G, Yokoyama H, Suzuki T, Tamura K. Upstream regulation for initiation of restricted Shh expression in the chick limb bud. Dev Dyn. 2017;246:417-430 pubmed publisher
    ..Comparison of the spatiotemporal patterns of gene expression between Shh and some candidate genes (Fgf8, Hoxd10, Hoxd11, Tbx2, and Alx4) upstream of Shh expression suggested that a combination of these genes' expression ..
  15. Booker B, Friedrich T, Mason M, Vandermeer J, Zhao J, Eckalbar W, et al. Bat Accelerated Regions Identify a Bat Forelimb Specific Enhancer in the HoxD Locus. PLoS Genet. 2016;12:e1005738 pubmed publisher
    ..5. Developing limb expression analysis of Hoxd10-Hoxd13 in Miniopterus natalensis bats showed a high-forelimb weak-hindlimb expression for Hoxd10-Hoxd11, similar ..
  16. Nakayama S, Satou K, Orito W, Ogasawara M. Ordered expression pattern of Hox and ParaHox genes along the alimentary canal in the ascidian juvenile. Cell Tissue Res. 2016;365:65-75 pubmed publisher
    ..Expression of Hox1 to Hox4 is restricted to the posterior region of pharyngeal derivatives...
  17. Fournier M, Lebert Ghali C, Bijl J. HOXA4 provides stronger engraftment potential to short-term repopulating cells than HOXB4. Stem Cells Dev. 2015;24:2413-22 pubmed publisher
    Genes of the HOX4 paralog group have been shown to expand hematopoietic stem cells (HSCs)...
  18. Chen J, Liu X, Yao X, Gao F, Bao B. Dorsal fin development in flounder, Paralichthys olivaceus: Bud formation and its cellular origin. Gene Expr Patterns. 2017;25-26:22-28 pubmed publisher
    ..The earliest gene expression in the dorsal fin bud was Hoxd10 at 3 days post-hatch larvae, then Hoxd9, Hoxd11 and Hoxd12...
  19. Brinkmeier M, Geister K, Jones M, Waqas M, Maillard I, Camper S. The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice. Biol Reprod. 2015;93:121 pubmed publisher
    ..Specifically, expression of Hoxa11 and Hoxd10 are altered in the epididymis of Ash1l mutant males and Hoxa10 is reduced in the uterus of Ash1l mutant females...
  20. Li X, Zheng L, Zhang F, Hu J, Chou J, Liu Y, et al. STARD13-correlated ceRNA network inhibits EMT and metastasis of breast cancer. Oncotarget. 2016;7:23197-211 pubmed publisher
    ..Here, we identify CDH5, HOXD1, and HOXD10 as putative STARD13 ceRNAs and they display concordant patterns with STARD13 in different metastatic potential ..
  21. Xu Y, Wang S, Tang C, Chen W. Upregulation of long non-coding RNA HIF 1α-anti-sense 1 induced by transforming growth factor-β-mediated targeting of sirtuin 1 promotes osteoblastic differentiation of human bone marrow stromal cells. Mol Med Rep. 2015;12:7233-8 pubmed publisher
    ..In addition, low expression of HIF1α‑AS1 was sufficient to block the expression of HOXD10. The present study further demonstrated that downregulation of HOXD10 by HIF1α‑AS1 interfered with ..
  22. Alvarado D, McCall K, Hecht J, Dobbs M, Gurnett C. Deletions of 5' HOXC genes are associated with lower extremity malformations, including clubfoot and vertical talus. J Med Genet. 2016;53:250-5 pubmed publisher
    ..Because HOXD10 has been implicated in the aetiology of congenital vertical talus, variation in its expression may contribute to ..
  23. Zakany J, Duboule D. Rescue of an aggressive female sexual courtship in mice by CRISPR/Cas9 secondary mutation in vivo. BMC Res Notes. 2018;11:193 pubmed publisher
    ..mouse line carrying the Atypical female courtship (HoxD Afc ) allele, where an ectopic accumulation of Hoxd10 transcripts was observed in a sparse population of cells in the adult isocortex, as a result of a partial deletion ..
  24. Ma Z, Chen Y, Min L, Li L, Huang H, Li J, et al. Augmented miR-10b expression associated with depressed expression of its target gene KLF4 involved in gastric carcinoma. Int J Clin Exp Pathol. 2015;8:5071-9 pubmed
    Previous studies have revealed several targets of miR-10b, such as syndecan-1, HOXD10, TBX5, and E-cadherin. In this study, we aimed to assess whether Krüppel-like factor 4 (KLF4) is a target gene of miR-10b in gastric cancer (GC)...
  25. Knight J, Kim E, Ivanov I, Davidson L, Goldsby J, Hullar M, et al. Comprehensive site-specific whole genome profiling of stromal and epithelial colonic gene signatures in human sigmoid colon and rectal tissue. Physiol Genomics. 2016;48:651-9 pubmed publisher
    ..In comparison, HOX genes (HOXA3, HOXD9, HOXD10, HOXD11, and HOXD-AS2, a HOXD cluster antisense RNA 2), and WNT5B expression were also significantly higher in ..
  26. An N, Luo X, Zhang M, Yu R. MicroRNA-376b promotes breast cancer metastasis by targeting Hoxd10 directly. Exp Ther Med. 2017;13:79-84 pubmed publisher
    ..Moreover, the luciferase assay and western blotting identified that Hoxd10 is the direct target of miR-376b during the regulation of breast cancer metastasis...
  27. Kim J, Siverly A, Chen D, Wang M, Yuan Y, Wang Y, et al. Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways. Cancer Res. 2016;76:6424-6435 pubmed
    ..Among the target genes of miR-10b, the tumor suppressor genes Tbx5 and Pten and the metastasis suppressor gene Hoxd10 are significantly upregulated by miR-10b deletion...
  28. Abdelmaksoud Dammak R, Chamtouri N, Triki M, Saadallah Kallel A, Ayadi W, Charfi S, et al. Overexpression of miR-10b in colorectal cancer patients: Correlation with TWIST-1 and E-cadherin expression. Tumour Biol. 2017;39:1010428317695916 pubmed publisher
    ..expression analysis of the downstream miR-10b targets has shown that there are associations between low HOXD10 messenger RNA and E-cadherin protein levels (p?<?0.0001, p?=?0...
  29. Wang R, Huang Q, Zhou R, Dong Z, Qi Y, Li H, et al. Sympathoexcitation in Rats With Chronic Heart Failure Depends on Homeobox D10 and MicroRNA-7b Inhibiting GABBR1 Translation in Paraventricular Nucleus. Circ Heart Fail. 2016;9:e002261 pubmed publisher
    ..We hypothesized that ANG II regulates sympathoexcitation through homeobox D10 (HoxD10), which regulates miR-7b in other tissues...
  30. Sakamoto K, Onimaru K, Munakata K, Suda N, Tamura M, Ochi H, et al. Heterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin development. PLoS ONE. 2009;4:e5121 pubmed publisher
    ..buds of chick and mouse, Shh expression is activated as soon as there is a morphological bud, concomitant with Hoxd10 expression...
  31. Baguma Nibasheka M, Fracassi A, Costain W, Moreno S, Kablar B. Role of skeletal muscle in motor neuron development. Histol Histopathol. 2016;31:699-719 pubmed publisher
    ..revealed that Kif5c, Stxbp1 and Polb, differentially expressed in the MyoD-/- limb muscle, and Ppargc1a, Glrb and Hoxd10, differentially expressed in the Myf5-/- back muscle, are actually regulators of motor neuron numbers...
  32. Guo Y, Peng Y, Gao D, Zhang M, Yang W, Linghu E, et al. Silencing HOXD10 by promoter region hypermethylation activates ERK signaling in hepatocellular carcinoma. Clin Epigenetics. 2017;9:116 pubmed publisher
    ..Dysregulation of HomeoboxD10 (HOXD10) was found to suppress or promote cancer progression in different cancer types...
  33. Yang H, Zhou J, Mi J, Ma K, Fan Y, Ning J, et al. HOXD10 acts as a tumor-suppressive factor via inhibition of the RHOC/AKT/MAPK pathway in human cholangiocellular carcinoma. Oncol Rep. 2015;34:1681-91 pubmed publisher
    b>HOXD10, a key regulator of cell-differentiated phenotype maintainence, has been demonstrated to be involved in the tumorigenesis of many human malignacies...
  34. Wang Y, Li L, Ye Z, Zhao Z, Yan Z. MicroRNA-10b promotes migration and invasion through Hoxd10 in human gastric cancer. World J Surg Oncol. 2015;13:259 pubmed publisher
    ..aims to investigate the effect of miR-10b overexpression on cancer cell proliferation, migration, invasion, and Hoxd10 expression...
  35. de Barros E Lima Bueno R, Ramão A, Pinheiro D, Alves C, Kannen V, Jungbluth A, et al. HOX genes: potential candidates for the progression of laryngeal squamous cell carcinoma. Tumour Biol. 2016;37:15087-15096 pubmed
    ..Additionally, siRNA assays confirmed that HOXC8, HOXD10, and HOXD11 genes might be critical for cell colony proliferation and cell migration...
  36. Zappavigna V, Falciola L, Helmer Citterich M, Mavilio F, Bianchi M. HMG1 interacts with HOX proteins and enhances their DNA binding and transcriptional activation. EMBO J. 1996;15:4981-91 pubmed
  37. Akbas G, Taylor H. HOXC and HOXD gene expression in human endometrium: lack of redundancy with HOXA paralogs. Biol Reprod. 2004;70:39-45 pubmed
    ..We hypothesized that HOXC10, HOXC11, HOXD10, and HOXD11, paralogs of HOXA10 and HOXA11, might also be involved in endometrial development...
  38. Osborne J, Hu C, Hawley C, Underwood L, O Brien T, Baker V. Expression of HOXD10 gene in normal endometrium and endometrial adenocarcinoma. J Soc Gynecol Investig. 1998;5:277-80 pubmed
    ..The purpose of this study was to determine the relative expression of HOXD10 in human endometrial adenocarcinomas...
  39. Xiao H, Li H, Yu G, Xiao W, Hu J, Tang K, et al. MicroRNA-10b promotes migration and invasion through KLF4 and HOXD10 in human bladder cancer. Oncol Rep. 2014;31:1832-8 pubmed publisher
    ..Meanwhile, protein levels of KLF4, HOXD10, E-cadherin and MMP14 were measured...
  40. Zhao X, Sun M, Zhao J, Leyva J, Zhu H, Yang W, et al. Mutations in HOXD13 underlie syndactyly type V and a novel brachydactyly-syndactyly syndrome. Am J Hum Genet. 2007;80:361-71 pubmed
    ..We suggest the term "HOXD13 limb morphopathies" for the spectrum of limb disorders caused by HOXD13 mutations...
  41. Zappavigna V, Renucci A, Izpisua Belmonte J, Urier G, Peschle C, Duboule D. HOX4 genes encode transcription factors with potential auto- and cross-regulatory capacities. EMBO J. 1991;10:4177-87 pubmed
    ..HOX4 complex homeoproteins in the genomic region containing the HOX4C promoter, between the human HOX4C and HOX4D genes. The HOX4C, HOX4D and Hox-4...
  42. Shen W, Krishnan K, Lawrence H, Largman C. The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol Cell Biol. 2001;21:7509-22 pubmed
  43. Redline R, Williams A, Patterson P, Collins T. Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts. Genomics. 1992;13:425-30 pubmed
    ..Genomic and cDNA clones containing the human HOX4E (also known as human Hox 4.5) gene were isolated. The gene contains two exons and spans about 5 kb of DNA...
  44. Levinsohn E, Shrimpton A, Cady R, Packard D, Hootnick D. Congenital vertical talus in four generations of the same family. Skeletal Radiol. 2004;33:649-54 pubmed
    ..presents four generations of a family with radiographically demonstrated congenital vertical talus (CVT) in whom a HOXD10 gene mutation was identified...
  45. Wang L, Jin C, Liu L, Zhang X, Ji S, Sun K. [Analysis of association between 5' HOXD gene and idiopathic congenital talipes equinovarus]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:653-6 pubmed
    Four single nucleotide polymorphisms (SNP) in HOXD10, HOXD12 and HOXD13 genes were chosen to investigate SNP and haplotypes distribution in idiopathic congenital talipes equinovarus nuclear pedigrees...
  46. Khan F, Sadeghi M, Gupta S, Wolkenhauer O. A Network-Based Integrative Workflow to Unravel Mechanisms Underlying Disease Progression. Methods Mol Biol. 2018;1702:247-276 pubmed publisher
    ..Analysis carried out by the workflow revealed that HOXD10, BCL2, and PGR are the most important factors affected in primary prostate samples, whereas, in the metastatic ..
  47. Vieira W, Sahin H, Wells K, McCusker C. Trimethylation of Histone 3 lysine 27 (H3K27me3) ChIP-PCR and transcriptional expression data of Ef1-alpha, cyp26A, HoxC10, HoxD10 and HoxD11 in the Xenopus XTC cell line. Data Brief. 2017;15:970-974 pubmed publisher
    ..Immunoprecipitation (ChIP-PCR), to detect the abundance of H3K27me3 marks on Ef1-alpha, cyp26A, HoxC10, HoxD10 and HoxD11 in the Xenopus XTC cell line...
  48. Fu Y, Li F, Zhao D, Zhang J, Lv Y, Li Ling J. Interaction between Tbx1 and Hoxd10 and connection with TGF?-BMP signal pathway during kidney development. Gene. 2014;536:197-202 pubmed publisher
    ..Precipitated proteins were verified with mass spectrometry. As discovered, Tbx1 binds with Hoxd10. Tbx1 and Hoxd10 genes also have similar expression profiles during murine kidney development...
  49. Li Q, Ding C, Chen C, Zhang Z, Xiao H, Xie F, et al. miR-224 promotion of cell migration and invasion by targeting Homeobox D 10 gene in human hepatocellular carcinoma. J Gastroenterol Hepatol. 2014;29:835-42 pubmed publisher
    ..A luciferase reporter assay was used to confirm that the HOXD10 gene was a direct target of miR-224...
  50. Hu X, Chen D, Cui Y, Li Z, Huang J. Targeting microRNA-23a to inhibit glioma cell invasion via HOXD10. Sci Rep. 2013;3:3423 pubmed publisher
    ..Moreover, we identified homeobox D10 (HOXD10) as a novel target for miR-23a...
  51. Limongi M, Pelliccia F, Gaddini L, Rocchi A. Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1. Cytogenet Cell Genet. 2000;90:151-3 pubmed
    ..1 respectively. Our results indicate that these homeobox genes lie between the two fragile regions. ..
  52. Wulfsberg E, Mirkinson L, Meister S. Autosomal dominant tetramelic postaxial oligodactyly. Am J Med Genet. 1993;46:579-83 pubmed
    ..The present family may represent a defect in Hox-4 gene patterning of hand and foot formation, an abnormality in morphogen gradient formation or alternately an inability of the most ulnar rays to respond to morphogen (receptor defect). ..
  53. Zakany J, Darbellay F, Mascrez B, Necsulea A, Duboule D. Control of growth and gut maturation by HoxD genes and the associated lncRNA Haglr. Proc Natl Acad Sci U S A. 2017;114:E9290-E9299 pubmed publisher
    ..This essential function could be abrogated by the dominant-negative effect of HOXD10 as shown by a genetic rescue approach, thus further illustrating the importance of posterior prevalence in ..
  54. Lin Y, Ou D, Chang H, Lin W, Hsu C, Chang P. Simultaneous visualization of the subfemtomolar expression of microRNA and microRNA target gene using HILO microscopy. Chem Sci. 2017;8:6670-6678 pubmed publisher
    ..a sensitive imaging method for the direct probing of miR-10b (miR-10b-3p, also called miR-10b*) and its target (HOXD10 mRNA) in fixed cells based on the specific recognition of molecular beacons combined with highly inclined and ..
  55. Wang S, Zhang C, Zhang Z, Qian W, Sun Y, Ji B, et al. Transcriptome analysis in primary colorectal cancer tissues from patients with and without liver metastases using next-generation sequencing. Cancer Med. 2017;6:1976-1987 pubmed publisher
    ..The validation showed that three most significantly upregulated DEGs were HOXD10, UGT2A3, and SLC13A2, whereas the five most significantly downregulated DEGs were SPP1, CXCL8, MMP3, OSM, and ..
  56. Bhatlekar S, Viswanathan V, Fields J, Boman B. Overexpression of HOXA4 and HOXA9 genes promotes self-renewal and contributes to colon cancer stem cell overpopulation. J Cell Physiol. 2018;233:727-735 pubmed publisher
    ..We previously reported that HOXA4 and HOXD10 are expressed in the colonic SC niche and are overexpressed in CRC...
  57. Eadon M, Hause R, Stark A, Cheng Y, Wheeler H, Burgess K, et al. Genetic Variants Contributing to Colistin Cytotoxicity: Identification of TGIF1 and HOXD10 Using a Population Genomics Approach. Int J Mol Sci. 2017;18: pubmed publisher
    ..021) and was associated with expression of the protein HOXD10 (homeobox protein D10; p = 7.17 × 10-5)...
  58. Shrimpton A, Levinsohn E, Yozawitz J, Packard D, Cady R, Middleton F, et al. A HOX gene mutation in a family with isolated congenital vertical talus and Charcot-Marie-Tooth disease. Am J Hum Genet. 2004;75:92-6 pubmed
    ..sequencing of six HOX genes and detection of a single missense mutation, M319K (956T-->A), in the HOXD10 gene. In the study family, this mutation was fully penetrant and exhibited significant evidence of linkage (LOD 6...
  59. Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M. The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature. 2004;427:749-53 pubmed
    ..By establishing competitive regulation, geminin functions as a coordinator of developmental and proliferative control. ..
  60. Sharpe D, Orr K, Moran M, White S, McQuaid S, Lappin T, et al. POU2F1 activity regulates HOXD10 and HOXD11 promoting a proliferative and invasive phenotype in head and neck cancer. Oncotarget. 2014;5:8803-15 pubmed
    ..Knockdown of HOXD10 in HNSCC cells caused decreased proliferation and invasion, whereas knockdown of HOXD11 reduced only invasion...
  61. Boncinelli E, Acampora D, Pannese M, D ESPOSITO M, Somma R, Gaudino G, et al. Organization of human class I homeobox genes. Genome. 1989;31:745-56 pubmed
    ..The existence of an ancestral complex locus might have predated the divergence of vertebrates and invertebrates. ..
  62. Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F. The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins. EMBO J. 1994;13:3339-47 pubmed
    ..Some of the DNA-protein complexes formed by the embryonic extracts are indistinguishable from those generated by HOXB3.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  63. Gurnett C, Keppel C, Bick J, Bowcock A, Dobbs M. Absence of HOXD10 mutations in idiopathic clubfoot and sporadic vertical talus. Clin Orthop Relat Res. 2007;462:27-31 pubmed
    ..A mutation in HOXD10 was previously identified in a family with isolated congenital vertical talus...
  64. Klein S, Dieterich L, Mathelier A, Chong C, Sliwa Primorac A, Hong Y, et al. DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C. J Cell Sci. 2016;129:2573-85 pubmed publisher
    ..Using transcription factor activity analysis, we identified the homeobox transcription factor HOXD10 to be specifically activated at early time points after VEGFR-3 stimulation, and to regulate expression of ..
  65. Zhao X, Reifler A, Schroeder M, Jaeckel E, Chervenak A, Wong K. Mechanisms creating transient and sustained photoresponses in mammalian retinal ganglion cells. J Gen Physiol. 2017;149:335-353 pubmed publisher
    ..photosensitive RGCs (ipRGCs) and transient ON responses in three types of direction-selective RGCs (TRHR+, Hoxd10+ ON, and Hoxd10+ ON-OFF cells)...
  66. von Heyking K, Roth L, Ertl M, Schmidt O, Calzada Wack J, Neff F, et al. The posterior HOXD locus: Its contribution to phenotype and malignancy of Ewing sarcoma. Oncotarget. 2016;7:41767-41780 pubmed publisher
    ..knock down of the dickkopf WNT signaling pathway inhibitor 2 (DKK2) resulted in a significant suppression of HOXD10, HOXD11 and HOXD13 while over-expression of DKK2 and stimulation with factors of the WNT signaling pathway such as ..
  67. Reddy S, Ohshiro K, Rayala S, Kumar R. MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functions. Cancer Res. 2008;68:8195-200 pubmed publisher
    ..We discovered that endogenous miR-7 expression is positively regulated by a homeodomain transcription factor, HoxD10, the loss of which leads to an increased invasiveness. HoxD10 directly interacts with the miR-7 chromatin...
  68. Redline R, Hudock P, MacFee M, Patterson P. Expression of AbdB-type homeobox genes in human tumors. Lab Invest. 1994;71:663-70 pubmed
    ..We analyzed normal and neoplastic tissues for the expression of three AbdB-type HOX genes; HOXD10, HOXA9, and HOXC9 to evaluate three hypotheses: (a) that tumors express HOX genes found in their tissue of origin, ..
  69. Cao Y, Gu J, Zhang Y, Wei W, Qu N, Wen D, et al. Aberrant hypermethylation of the HOXD10 gene in papillary thyroid cancer with BRAFV600E mutation. Oncol Rep. 2018;39:338-348 pubmed publisher
    ..The present study aimed to analyze the function and methylation status of the HOXD10 gene in PTC and aimed to identify relationships between HOXD10 methylation, HOXD10 expression, BRAF mutation and ..
  70. Goodman F. Limb malformations and the human HOX genes. Am J Med Genet. 2002;112:256-65 pubmed
    ..Limb malformations may also result from chromosomal deletions involving the HOXD and HOXA clusters, and from regulatory mutations affecting single or multiple HOX genes...
  71. Peverali F, D ESPOSITO M, Acampora D, Bunone G, Negri M, Faiella A, et al. Expression of HOX homeogenes in human neuroblastoma cell culture lines. Differentiation. 1990;45:61-9 pubmed
    ..On the other hand, in every line studied, morphological maturation toward a neuronal differentiated phenotype appears to be associated with increased HOX gene expression...
  72. Yu X, Li Z, Shen J, Wu W, Liang J, Weng X, et al. MicroRNA-10b promotes nucleus pulposus cell proliferation through RhoC-Akt pathway by targeting HOXD10 in intervetebral disc degeneration. PLoS ONE. 2013;8:e83080 pubmed publisher
    ..Moreover, miR-10b levels were associated with disc degeneration grade and downregulation of HOXD10. In cultured nucleus pulposus cells, miR-10b overexpression stimulated cell proliferation with concomitant ..
  73. Shanmugam K, Green N, Rambaldi I, Saragovi H, Featherstone M. PBX and MEIS as non-DNA-binding partners in trimeric complexes with HOX proteins. Mol Cell Biol. 1999;19:7577-88 pubmed
    ..vii) We observe an additional trimer class involving non-DNA-bound PBX and DNA-bound MEIS-HOXD9 or MEIS-HOXD10 heterodimers that is enhanced by mutation of the PBX homeodomain...
  74. Del Campo M, Jones M, Veraksa A, Curry C, Jones K, Mascarello J, et al. Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster. Am J Hum Genet. 1999;65:104-10 pubmed
  75. Hakami F, Darda L, Stafford P, Woll P, Lambert D, Hunter K. The roles of HOXD10 in the development and progression of head and neck squamous cell carcinoma (HNSCC). Br J Cancer. 2014;111:807-16 pubmed publisher
    ..microarray revealed changes in HOX gene expression in head and neck squamous cell carcinoma (HNSCC), particularly HOXD10. HOXD10 expression was assessed by qPCR and immunoblotting in vitro and by immunohistochemistry (IHC) in tissues...
  76. Vardhini N, Rao P, Murthy P, Sudhakar G. HOXD10 expression in human breast cancer. Tumour Biol. 2014;35:10855-60 pubmed publisher
    ..In this study, we analyzed the expression pattern of a homeobox gene (HOXD10) in human invasive ductal breast cancer tissues and normal tissues...