HOXA13

Summary

Gene Symbol: HOXA13
Description: homeobox A13
Alias: HOX1, HOX1J, homeobox protein Hox-A13, homeo box 1J, homeo box A13, homeobox protein HOXA13, homeobox protein Hox-1J, transcription factor HOXA13
Species: human
Products:     HOXA13

Top Publications

  1. Zhao Y, Potter S. Functional specificity of the Hoxa13 homeobox. Development. 2001;128:3197-207 pubmed
    ..models that predict functional equivalence of all Hox genes and to initiate a search for the downstream targets of Hoxa13, we have performed a homeobox swap by replacing the homeobox of the Hoxa11 gene with that of the Hoxa13 gene...
  2. Mortlock D, Innis J. Mutation of HOXA13 in hand-foot-genital syndrome. Nat Genet. 1997;15:179-80 pubmed
    ..We report the identification of a HOXA13 nonsense mutation in a family with hand-foot-genital syndrome...
  3. Innis J, Goodman F, Bacchelli C, Williams T, Mortlock D, Sateesh P, et al. A HOXA13 allele with a missense mutation in the homeobox and a dinucleotide deletion in the promoter underlies Guttmacher syndrome. Hum Mutat. 2002;19:573-4 pubmed
    ..HFGS is caused by mutations in the HOXA13 gene...
  4. Utsch B, Becker K, Brock D, Lentze M, Bidlingmaier F, Ludwig M. A novel stable polyalanine [poly(A)] expansion in the HOXA13 gene associated with hand-foot-genital syndrome: proper function of poly(A)-harbouring transcription factors depends on a critical repeat length?. Hum Genet. 2002;110:488-94 pubmed
    ..As observed in our family, all the expanded tracts encoding polyalanine, either reported for HOXA13 or HOXD13, are quite stable when transmitted within affected families...
  5. Williams T, Williams M, Innis J. Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev Biol. 2005;277:457-71 pubmed
    ..We show that Hoxa13 and Hoxd13 expression does not overlap with that of Meis1-3 in the developing limb; however, coexpression occurs ..
  6. Utsch B, McCabe C, Galbraith K, Gonzalez R, Born M, Dotsch J, et al. Molecular characterization of HOXA13 polyalanine expansion proteins in hand-foot-genital syndrome. Am J Med Genet A. 2007;143A:3161-8 pubmed
    ..syndrome (HFGS) with typical skeletal and genitourinary anomalies due to a 14-residue polyalanine expansion in HOXA13. This is the largest (32 residues) polyalanine tract so far described for any polyalanine mutant protein...
  7. Shaut C, Keene D, Sorensen L, Li D, Stadler H. HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet. 2008;4:e1000073 pubmed publisher
    ..In this report, we demonstrate that HOXA13 plays an essential role in labyrinth vessel formation...
  8. Jorgensen E, Ruman J, Doherty L, Taylor H. A novel mutation of HOXA13 in a family with hand-foot-genital syndrome and the role of polyalanine expansions in the spectrum of Müllerian fusion anomalies. Fertil Steril. 2010;94:1235-8 pubmed publisher
    ..Sequence analysis of HOXA13 in members of a family with HFGS (3 affected, 1 unaffected); sequence analysis of HOXA13 in biopsy samples ..
  9. Post L, Innis J. Infertility in adult hypodactyly mice is associated with hypoplasia of distal reproductive structures. Biol Reprod. 1999;61:1402-8 pubmed
    Hypodactyly (Hoxa13(Hd)) mice have a 50-base-pair deletion in Hoxa13, and rare surviving homozygotes of both sexes are infertile...

More Information

Publications108 found, 100 shown here

  1. Williams T, Williams M, Heaton J, Gelehrter T, Innis J. Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability. Nucleic Acids Res. 2005;33:4475-84 pubmed
    ..To identify candidate protein interactors of HOXA13, we created and screened an E11.5-E12.5, distal limb bud yeast two-hybrid prey library...
  2. Goodman F, Bacchelli C, Brady A, Brueton L, Fryns J, Mortlock D, et al. Novel HOXA13 mutations and the phenotypic spectrum of hand-foot-genital syndrome. Am J Hum Genet. 2000;67:197-202 pubmed
    ..A nonsense mutation in the homeobox of HOXA13 has been identified in one affected family, making HFGS the second human syndrome shown to be caused by a HOX gene ..
  3. Mazzoni E, Mahony S, Peljto M, Patel T, Thornton S, McCuine S, et al. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nat Neurosci. 2013;16:1191-1198 pubmed publisher
    ..neural progenitors with retinoic acid leads to activation and binding of retinoic acid receptors (RARs) to the Hox1-Hox5 chromatin domains, which is followed by a rapid domain-wide removal of H3K27me3 and acquisition of cervical ..
  4. Di Giacomo D, Pierini V, Barba G, Ceccarelli V, Vecchini A, Mecucci C. Blast crisis Ph+ chronic myeloid leukemia with NUP98/HOXA13 up-regulating MSI2. Mol Cytogenet. 2014;7:42 pubmed publisher
    ..Herein we describe a t(7;11)(p15;p15) originating a NUP98 fusion with HOXA13, at 7p15, in a 39 year-old man in blast crisis of Ph-positive CML...
  5. Krasovec G, Robine K, Queinnec E, Karaiskou A, Chambon J. Ci-hox12 tail gradient precedes and participates in the control of the apoptotic-dependent tail regression during Ciona larva metamorphosis. Dev Biol. 2019;448:237-246 pubmed publisher
    ..Fundamental genes such as Ci-hox1, Ci-hox12 and Ci-wnt5, classically involved in chordates A/P polarity and patterning, are controlled by these ..
  6. Wollesen T, Scherholz M, Rodríguez Monje S, Redl E, Todt C, Wanninger A. Brain regionalization genes are co-opted into shell field patterning in Mollusca. Sci Rep. 2017;7:5486 pubmed publisher
    The 'brain regionalization genes' Six3/6, Otx, Pax2/5/8, Gbx, and Hox1 are expressed in a similar fashion in the deuterostome, ecdysozoan, and the cephalopod brain, questioning whether this holds also true for the remaining Mollusca...
  7. Dokmeci F, Teksen F, Cetinkaya S, Ozkan T, Kaplan F, Kose K. Expressions of homeobox, collagen and estrogen genes in women with uterine prolapse. Eur J Obstet Gynecol Reprod Biol. 2019;233:26-29 pubmed publisher
    ..We aimed to study the gene expression profiles of the genes HomeoboxA11 (HOXA11), HomeoboxA13 (HOXA13), Collagen Type I (COL1A), Collagen Type III (COL3A), estrogen receptor genes (ESR1 and ESR2) of round (RL) and ..
  8. Martinez Abadias N, Mateu R, Niksic M, Russo L, Sharpe J. Geometric Morphometrics on Gene Expression Patterns Within Phenotypes: A Case Example on Limb Development. Syst Biol. 2016;65:194-211 pubmed publisher
    ..of the limb bud shape with the expression patterns of two relevant genes for limb morphogenesis, Hoxa11 and Hoxa13. We devised a multiple thresholding method to semiautomatically segment gene domains at several expression levels ..
  9. Scotti M, Kherdjemil Y, Roux M, Kmita M. A Hoxa13:Cre mouse strain for conditional gene manipulation in developing limb, hindgut, and urogenital system. Genesis. 2015;53:366-76 pubmed publisher
    ..Here we report on the generation of the Hoxa13:Cre line, in which the Cre gene is inserted in the endogenous Hoxa13 gene...
  10. Papageorgiou S. Physical Forces May Cause the HoxD Gene Cluster Elongation. Biology (Basel). 2017;6: pubmed publisher
    Hox gene collinearity was discovered be Edward B. Lewis in 1978. It consists of the Hox1, Hox2, Hox3 ordering of the Hox genes in the chromosome from the telomeric to the centromeric side of the chromosome...
  11. Kim T, Lee E, Choi J, Yim S, Lee S, Kang J, et al. Identification of novel susceptibility loci associated with hepatitis B surface antigen seroclearance in chronic hepatitis B. PLoS ONE. 2018;13:e0199094 pubmed publisher
    ..The flanking genes at these loci including MPEG1, DTX4, MTX3, and HOXA13 were suggested to have functional significance...
  12. Xu F, Gao F. Liuwei Dihuang pill cures postmenopausal osteoporosis with kidney-Yin deficiency: Potential therapeutic targets identified based on gene expression profiling. Medicine (Baltimore). 2018;97:e11659 pubmed publisher
    ..NCOA3, TCF4, DUSP6, PELI2, and STX7 were predicted to be regulated by HOXA13. In the PMO-KY treatment, NCOA3, TCF4, DUSP6, PELI2, and STX7 might be the potential therapeutic targets of LDP...
  13. Watson C, Crinnion L, Harrison S, Lascelles C, Antanaviciute A, Carr I, et al. A Chromosome 7 Pericentric Inversion Defined at Single-Nucleotide Resolution Using Diagnostic Whole Genome Sequencing in a Patient with Hand-Foot-Genital Syndrome. PLoS ONE. 2016;11:e0157075 pubmed publisher
    ..Significantly, the 7p15 breakpoint was located 523 kb upstream of HOXA13, the locus for hand-foot-genital syndrome...
  14. Joo M, Park J, Chun H. Impact of homeobox genes in gastrointestinal cancer. World J Gastroenterol. 2016;22:8247-8256 pubmed
    ..Recently, several HOX genes were reported to have specific roles in GI cancers; for example, HOXA13 in esophageal squamous cell cancer and HOXB7 in stomach and colorectal cancers...
  15. He Y, Song X, Zhao Z, Zhao H. HOXA13 upregulation in gastric cancer is associated with enhanced cancer cell invasion and epithelial-to-mesenchymal transition. Eur Rev Med Pharmacol Sci. 2017;21:258-265 pubmed
    In this study, we investigated the association between HOXA13 dysregulation and gastric cancer progression...
  16. Leite Castro J, Beviano V, Rodrigues P, Freitas R. HoxA Genes and the Fin-to-Limb Transition in Vertebrates. J Dev Biol. 2016;4: pubmed publisher
    ..Within these genes, HoxA11 and HoxA13 were proposed to have played an essential role in the enigmatic evolutionary transition from fish fins to ..
  17. Luo H, Wang F, Zha J, Li H, Yan B, Du Q, et al. CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia. Blood. 2018;: pubmed publisher
    ..site located between HOXA7 and HOXA9 genes (CBS7/9) is critical for establishing and maintaining aberrant HOXA9-HOXA13 gene expression in AML...
  18. Nakayama S, Satou K, Orito W, Ogasawara M. Ordered expression pattern of Hox and ParaHox genes along the alimentary canal in the ascidian juvenile. Cell Tissue Res. 2016;365:65-75 pubmed publisher
    ..Expression of Hox1 to Hox4 is restricted to the posterior region of pharyngeal derivatives...
  19. Yu H, Xu Y, Zhang D, Liu G. Long noncoding RNA LUCAT1 promotes malignancy of ovarian cancer through regulation of miR-612/HOXA13 pathway. Biochem Biophys Res Commun. 2018;503:2095-2100 pubmed publisher
    ..Through online predictive tools and functional experiments, we demonstrated that LUCAT1 and HOXA13 were targets of miR-612. We showed that LUCAT1 and miR-612 suppressed each other in a reciprocal way...
  20. Sang Y, Zhou F, Wang D, Bi X, Liu X, Hao Z, et al. Up-regulation of long non-coding HOTTIP functions as an oncogene by regulating HOXA13 in non-small cell lung cancer. Am J Transl Res. 2016;8:2022-32 pubmed
    ..In addition, we identified HOTTIP as a transcriptional regulator of HOXA13 in lung cancer cell...
  21. Liu Z, Li E, Xu D, Sun W, Hong Y, Zhao W, et al. Genetic research and structural dysplasia assessment of anorectal malformations in neonatal male rats induced by di(n-butyl) phthalate. Environ Toxicol. 2016;31:261-8 pubmed publisher
    ..of these androgen-related genes such as sonic hedgehog, Gli2, Gli3, bone morphogenetic protein 4, Wnt5a, Hoxa13, Hoxd13, fibroblast growth factor 10, and fibroblast growth factor receptor 2 were found in terminal rectum of the ..
  22. Neufeld S, Wang F, Cobb J. Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. Genetics. 2014;198:1117-26 pubmed publisher
    ..restricted to the proximal limb along with Hoxd9 and Hoxa11 expression, juxtaposing the distal expression of Hoxa13 and Hoxd13...
  23. Kavalieris L, O Sullivan P, Suttie J, Pownall B, Gilling P, Chemasle C, et al. A segregation index combining phenotypic (clinical characteristics) and genotypic (gene expression) biomarkers from a urine sample to triage out patients presenting with hematuria who have a low probability of urothelial carcinoma. BMC Urol. 2015;15:23 pubmed publisher
    ..Expression of IGFBP5, HOXA13, MDK, CDK1 and CXCR2 genes in a voided urine sample (genotypic) and age, gender, frequency of macrohematuria and ..
  24. Zhu Y, Li E, Sun W, Xu D, Liu Z, Zhao W, et al. Maternal exposure to di-n-butyl phthalate (DBP) induces combined anorectal and urogenital malformations in male rat offspring. Reprod Toxicol. 2016;61:169-76 pubmed publisher
    ..Further, decreased mRNA levels of Shh, Fgf10, Gli2, Gli3, Bmp4, Wnt5a, Hoxa13, Hoxd13, Fgfr2 and AR were observed in TR and GT in the ARMs & hypospadias group...
  25. Wen Y, Shu F, Chen Y, Chen Y, Lan Y, Duan X, et al. The prognostic value of HOXA13 in solid tumors: A meta-analysis. Clin Chim Acta. 2018;483:64-68 pubmed publisher
    The prognostic value of homeobox (HOX) A13 (HOXA13) in cancer remains uncertain due to limitations of sample size and discrete outcome in previous studies...
  26. Cheng Y, Jutooru I, Chadalapaka G, Corton J, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 2015;6:10840-52 pubmed
    ..by MLL and not WDR5 and, in contrast to previous studies in liver cancer cells, HOTTIP does not regulate HOXA13 but plays a role in regulation of several other HOX genes including HOXA10, HOXB2, HOXA11, HOXA9 and HOXA1...
  27. Jerković I, Ibrahim D, Andrey G, Haas S, Hansen P, Janetzki C, et al. Genome-Wide Binding of Posterior HOXA/D Transcription Factors Reveals Subgrouping and Association with CTCF. PLoS Genet. 2017;13:e1006567 pubmed publisher
    ..binding profiles revealed that the HOX-TFs are clustered in two subgroups (Group 1: HOXA/D9, HOXA/D10, HOXD12, and HOXA13 and Group 2: HOXA/D11 and HOXD13), which are characterized by differences in their sequence specificity and by the ..
  28. Uzkudun M, Marcon L, Sharpe J. Data-driven modelling of a gene regulatory network for cell fate decisions in the growing limb bud. Mol Syst Biol. 2015;11:815 pubmed publisher
    ..First, we map the expression patterns of the PD markers Meis1, Hoxa11 and Hoxa13 into a dynamic description of the tissue movements that drive limb morphogenesis...
  29. Reddy P, Unni M, Gungi A, Agarwal P, Galande S. Evolution of Hox-like genes in Cnidaria: Study of Hydra Hox repertoire reveals tailor-made Hox-code for Cnidarians. Mech Dev. 2015;138 Pt 2:87-96 pubmed publisher
    ..Phylogenetic analysis of these genes shows bilaterian counterparts of Hox1, Gsx and Mox...
  30. Gonzalez P, Uhlinger K, Lowe C. The Adult Body Plan of Indirect Developing Hemichordates Develops by Adding a Hox-Patterned Trunk to an Anterior Larval Territory. Curr Biol. 2017;27:87-95 pubmed publisher
    ..The larval ectoderm has an anterior molecular signature, while most of the trunk, defined by the expression of hox1-7, is absent...
  31. Qu L, Zhong Y, Zheng Z, Zhao R. CDH17 is a downstream effector of HOXA13 in modulating the Wnt/β-catenin signaling pathway in gastric cancer. Eur Rev Med Pharmacol Sci. 2017;21:1234-1241 pubmed
    In this study, we investigated the mechanism underlying co-upregulation of HOXA13 and CDH17 in gastric cancer, the signaling pathway in which HOXA13 and CDH17 involve in and their functional role in gastric cancer cells...
  32. Owens K, Quinonez S, Thomas P, Keegan C, Lefebvre N, Roulston D, et al. Analysis of de novo HOXA13 polyalanine expansions supports replication slippage without repair in their generation. Am J Med Genet A. 2013;161A:1019-27 pubmed publisher
    ..We identified two de novo cases of hand-foot-genital syndrome (HFGS) associated with polyalanine expansions in HOXA13 that afforded rare opportunities to investigate the mechanism...
  33. Durston A, Zhu K. A time space translation hypothesis for vertebrate axial patterning. Semin Cell Dev Biol. 2015;42:86-93 pubmed publisher
    ..Hox functionality is implicated because knocking out the Hox1 paralogue group not only disrupts expression of Hox1 genes but also of the whole spatially collinear axial Hox ..
  34. Fritsch M, Wollesen T, de Oliveira A, Wanninger A. Unexpected co-linearity of Hox gene expression in an aculiferan mollusk. BMC Evol Biol. 2015;15:151 pubmed publisher
    ..In A. crinita the Hox genes Acr-Hox1-5, Hox7 and Post2 are expressed in a co-linear pattern along the antero-posterior axis, but not in molluscan-..
  35. Nagy I, Kovács K, Rákhely G, Maróti G. HupO, a Novel Regulator Involved in Thiosulfate-Responsive Control of HupSL [NiFe]-Hydrogenase Synthesis in Thiocapsa roseopersicina. Appl Environ Microbiol. 2016;82:2039-2049 pubmed publisher
    ..purple sulfur bacterium Thiocapsa roseopersicina harbors four functional [NiFe]-hydrogenases: HynSL, HupSL, Hox1, and Hox2...
  36. Carmichael S, Ma C, Choudhry S, Lammer E, Witte J, Shaw G. Hypospadias and genes related to genital tubercle and early urethral development. J Urol. 2013;190:1884-92 pubmed publisher
    ..We examined 293 relatively common tag single nucleotide polymorphisms in BMP4, BMP7, FGF8, FGF10, FGFR2, HOXA13, HOXD13, HOXA4, HOXB6, SRY, WT1, WTAP, SHH, GLI1, GLI2 and GLI3...
  37. Saiz Lopez P, Chinnaiya K, Campa V, Delgado I, Ros M, Towers M. An intrinsic timer specifies distal structures of the vertebrate limb. Nat Commun. 2015;6:8108 pubmed publisher
    ..cells from early to late chick wing buds, we demonstrate that distal mesenchyme cells intrinsically time Hoxa13 expression, cell cycle parameters and the duration of the overlying apical ectodermal ridge...
  38. Tulenko F, Massey J, Holmquist E, Kigundu G, Thomas S, Smith S, et al. Fin-fold development in paddlefish and catshark and implications for the evolution of the autopod. Proc Biol Sci. 2017;284: pubmed publisher
    ..Our data demonstrate that in basal gnathostomes, the autopod marker HoxA13 co-localizes with the dermoskeleton component And1 to mark the position of the fin-fold, supporting ..
  39. Ge Y, Yan X, Jin Y, Yang X, Yu X, Zhou L, et al. MiRNA-192 [corrected] and miRNA-204 Directly Suppress lncRNA HOTTIP and Interrupt GLS1-Mediated Glutaminolysis in Hepatocellular Carcinoma. PLoS Genet. 2015;11:e1005726 pubmed publisher
    ..Besides the known targets (multiple 5' end HOX A genes, i.e. HOXA13), glutaminase (GLS1) was identified as a potential downstream target of the miR-192/-204-HOTTIP axis in HCC...
  40. Mitogawa K, Makanae A, Satoh A. Hyperinnervation improves Xenopus laevis limb regeneration. Dev Biol. 2018;433:276-286 pubmed publisher
    ..Blastemas grown in a hyperinnervated forelimb upregulate limb patterning-related genes (shh, lmx1b, and hoxa13). Nerves projecting their axons to limbs express some growth factors (bmp7, fgf2, fgf8, and shh)...
  41. Fujiwara S, Canestro C. Reporter Analyses Reveal Redundant Enhancers that Confer Robustness on Cis-Regulatory Mechanisms. Adv Exp Med Biol. 2018;1029:69-79 pubmed publisher
    Reporter analyses of Hox1 and Brachyury (Bra) genes have revealed examples of redundant enhancers that provide regulatory robustness...
  42. Kherdjemil Y, Lalonde R, Sheth R, Dumouchel A, de Martino G, Pineault K, et al. Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state. Nature. 2016;539:89-92 pubmed publisher
    ..Here we show that the mutually exclusive expression of the mouse genes Hoxa11 and Hoxa13, which were previously proposed to be involved in the origin of the tetrapod limb, is required for the pentadactyl ..
  43. Nakamura T, Gehrke A, Lemberg J, Szymaszek J, Shubin N. Digits and fin rays share common developmental histories. Nature. 2016;537:225-228 pubmed publisher
    ..We show that cells marked by the activity of an autopodial hoxa13 enhancer exclusively form elements of the fin fold, including the osteoblasts of the dermal rays...
  44. Tas E, Sebastian J, Madan Khetarpal S, Sweet P, Yatsenko A, Pollock N, et al. Familial deletion of the HOXA gene cluster associated with Hand-Foot-Genital syndrome and phenotypic variability. Am J Med Genet A. 2017;173:221-224 pubmed publisher
    ..This disorder is associated with loss-of-function mutations in the HOXA13 gene. HOXA13 plays an important role in the development of distal limbs and lower genitourinary tract of the fetus...
  45. Chandrasekaran G, Hwang E, Kang T, Kwon D, Park K, Lee J, et al. In silico analysis of the deleterious nsSNPs (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer. Chem Biol Drug Des. 2017;90:188-199 pubmed publisher
    The human HOXB13 gene encodes a transcription factor containing a DNA-binding homeobox domain and a HoxA13 N-terminal domain. SNP is considered to be the primary genetic cause for hereditary prostate cancer (PCa)...
  46. Vaglia J, Fornari C, Evans P. Posterior tail development in the salamander Eurycea cirrigera: exploring cellular dynamics across life stages. Dev Genes Evol. 2017;227:85-99 pubmed publisher
    ..Embryonic expression patterns of HoxA13 and C13 are shown with in situ hybridization...
  47. Sasakura Y. The Enhancer Trap in Ciona. Adv Exp Med Biol. 2018;1029:121-129 pubmed publisher
    ..the presence of enhancers sensitive to the orientation of the gene that they regulate, and the functions of the Hox1 gene have been revealed...
  48. Parker H, Pushel I, Krumlauf R. Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest. Dev Biol. 2018;444 Suppl 1:S67-S78 pubmed publisher
    ..We highlight early roles for Hox1 genes in cNCC specification, proposing that this may be achieved, in part, by regulation of the balance between ..
  49. de Stanchina E, Gabellini D, Norio P, Giacca M, Peverali F, Riva S, et al. Selection of homeotic proteins for binding to a human DNA replication origin. J Mol Biol. 2000;299:667-80 pubmed
    ..All of them, namely HOXA13, HOXC10 and HOXC13, are orthologues of the Abdominal-B gene of Drosophila melanogaster and are members of the ..
  50. Dhamija N, Choudhary D, Ladha J, Pillai B, Mitra D. Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. FEBS J. 2015;282:595-610 pubmed publisher
  51. Li Z, Zhao X, Zhou Y, Liu Y, Zhou Q, Ye H, et al. The long non-coding RNA HOTTIP promotes progression and gemcitabine resistance by regulating HOXA13 in pancreatic cancer. J Transl Med. 2015;13:84 pubmed publisher
    ..Quantitative real-time PCR was used to determine the levels of HOTTIP and HOXA13 transcripts in PDAC cell lines and 90 PDAC samples from patients...
  52. Liu L, Li H, Dargahi D, Shynlova O, Slater D, Jones S, et al. HoxA13 Regulates Phenotype Regionalization of Human Pregnant Myometrium. J Clin Endocrinol Metab. 2015;100:E1512-22 pubmed publisher
    ..Homeobox A13 (HoxA13), prostacyclin synthase (PTGIS), and periostin (POSTN) genes are more highly expressed in LUS than FUN of ..
  53. Peng L, He Q, Li X, Shuai L, Chen H, Li Y, et al. [Effect of Homeobox A13 transfection on epithelial-mesenchymal transition and bone morphogenetic protein-7 expression in kidney tubular epithelial cells]. Zhongguo Dang Dai Er Ke Za Zhi. 2015;17:1342-7 pubmed
    To examine the transfection of Homeobox A13 (HOXA13) on epithelial-mesenchymal transition (EMT) and the expression of bone morphogenetic protein-7 (BMP-7) induced by albumin-overload in human kidney tubular epithelial cells (HKCs)...
  54. Quagliata L, Quintavalle C, Lanzafame M, Matter M, Novello C, Di Tommaso L, et al. High expression of HOXA13 correlates with poorly differentiated hepatocellular carcinomas and modulates sorafenib response in in vitro models. Lab Invest. 2018;98:95-105 pubmed publisher
    ..Among HOX genes, HOXA13 is most overexpressed in HCC and is known to be directly regulated by the long non-coding RNA HOTTIP...
  55. Goodman F, Scambler P. Human HOX gene mutations. Clin Genet. 2001;59:1-11 pubmed
    ..human HOX genes have been shown to cause congenital malformations; HOXD13, which is mutated in synpolydactyly, and HOXA13, which is mutated in Hand-Foot-Genital syndrome...
  56. Connell K, Guess M, Tate A, Andikyan V, Bercik R, Taylor H. Diminished vaginal HOXA13 expression in women with pelvic organ prolapse. Menopause. 2009;16:529-33 pubmed publisher
    Homeobox genes are transcriptional regulators that orchestrate embryonic development. The HOXA13 gene is responsible for the development of the vagina and regulates extracellular matrix constituents...
  57. Shen L, Chen K. Exploration of target genes of HOXA13 in esophageal squamous cell carcinoma cell line. Cancer Lett. 2011;312:18-23 pubmed publisher
    ..we found that the median survival time of patients with ESCC (Esophageal squamous cell carcinoma) expressing HOXA13 was significantly shorter than those with HOXA13-negative ESCC and we also demonstrated that knockdown of HOXA13 ..
  58. Han Y, Tu W, Wen Y, Li D, Qiu G, Tang H, et al. Identification and validation that up-expression of HOXA13 is a novel independent prognostic marker of a worse outcome in gastric cancer based on immunohistochemistry. Med Oncol. 2013;30:564 pubmed publisher
    ..We found several differentially expressed HOX genes in gastric cancers, especially HOXA10 (11/12) and HOXA13 (11/12) with significantly higher expression in the cancerous tissues...
  59. Quagliata L, Matter M, Piscuoglio S, Arabi L, Ruiz C, Procino A, et al. Long noncoding RNA HOTTIP/HOXA13 expression is associated with disease progression and predicts outcome in hepatocellular carcinoma patients. Hepatology. 2014;59:911-23 pubmed publisher
    ..The HOTTIP gene is located in physical contiguity with HOXA13 and directly controls the HOXA locus gene expression by way of interaction with the WDR5/MLL complex...
  60. Pan T, Jia W, Yao Q, Sun Q, Ren W, Huang M, et al. Overexpression of HOXA13 as a potential marker for diagnosis and poor prognosis of hepatocellular carcinoma. Tohoku J Exp Med. 2014;234:209-19 pubmed
    b>HOXA13 is a member of homeobox genes that encode transcription factors regulating embryonic development and cell fate...
  61. Duan R, Han L, Wang Q, Wei J, Chen L, Zhang J, et al. HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways. Oncotarget. 2015;6:27778-93 pubmed publisher
    Homeobox (HOX) genes, including HOXA13, are involved in human cancer. We found that HOXA13 expression was associated with glioma grade and prognosis...
  62. Wallis M, Tsurusaki Y, Burgess T, Borzi P, Matsumoto N, Miyake N, et al. Dual genetic diagnoses: Atypical hand-foot-genital syndrome and developmental delay due to de novo mutations in HOXA13 and NRXN1. Am J Med Genet A. 2016;170:717-24 pubmed publisher
    ..1123G>T, p.Val375Phe) in exon 2 of the HOXA13 gene, predicted to be damaging and located in the homeobox domain...
  63. Yoshida K, Nakahata A, Treen N, Sakuma T, Yamamoto T, Sasakura Y. Hox-mediated endodermal identity patterns pharyngeal muscle formation in the chordate pharynx. Development. 2017;144:1629-1634 pubmed publisher
    ..Here, we show that Hox1 is essential for the establishment of AP axial identity of the endostyle, a major structure of the pharyngeal ..
  64. Wu D, Wang S, Liu C, Wuputra K, Kato K, Lee Y, et al. Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells. Stem Cells. 2017;35:2115-2128 pubmed publisher
    ..We examined the role of various long noncoding RNAs (lncRNAs)-homeobox protein HOXA13 axis on the switching of the oncogenic function of bone morphogenetic protein 7 (BMP7), which is ..
  65. Luo Z, Rhie S, Lay F, Farnham P. A Prostate Cancer Risk Element Functions as a Repressive Loop that Regulates HOXA13. Cell Rep. 2017;21:1411-1417 pubmed publisher
    ..Our results suggest that the risk element affects the expression of HOXA13 and HOTTIP, but not other genes in the HOXA locus, via a repressive loop...
  66. Yokoyama E, Smith Pellegrin D, Sanchez S, Molina B, Rodriguez A, Juarez R, et al. 7p15 deletion as the cause of hand-foot-genital syndrome: a case report, literature review and proposal of a minimum region for this phenotype. Mol Cytogenet. 2017;10:42 pubmed publisher
    ..Generally, this syndrome occurs due to point mutations that cause loss of function of the HOXA13 gene, which is located on 7p15; however, there are some patients with HFGS caused by interstitial deletions in ..
  67. Barry S, Crow K. The role of HoxA11 and HoxA13 in the evolution of novel fin morphologies in a representative batoid (Leucoraja erinacea). Evodevo. 2017;8:24 pubmed publisher
    ..A recent study identified a novel apical ectodermal ridge (AER) associated with the development of the anterior pectoral fin in the little skate, but the role of the posterior HoxA genes was not featured during skate fin development...
  68. Fujino T, Suzuki A, Ito Y, Ohyashiki K, Hatano Y, Miura I, et al. Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). Blood. 2002;99:1428-33 pubmed
    ..of the homeodomain of HOXA demonstrated that NUP98 was fused in-frame to HOXA11 in the patient with CML and to HOXA13 in the patient with MDS. The chromosomal breakpoints on 7p15 were located within introns of HOXA11 or HOXA13 genes...
  69. Zhang Y, Larsen C, Stadler H, Ames J. Structural basis for sequence specific DNA binding and protein dimerization of HOXA13. PLoS ONE. 2011;6:e23069 pubmed publisher
    The homeobox gene (HOXA13) codes for a transcription factor protein that binds to AT-rich DNA sequences and controls expression of genes during embryonic morphogenesis...
  70. Sheth R, Barozzi I, Langlais D, Osterwalder M, Nemec S, Carlson H, et al. Distal Limb Patterning Requires Modulation of cis-Regulatory Activities by HOX13. Cell Rep. 2016;17:2913-2926 pubmed publisher
    ..Loss of HOXA13 and HOXD13 transcription factors (HOX13) leads to digit agenesis in mice, but how HOX13 proteins regulate ..
  71. Pradeepa M, McKenna F, Taylor G, Bengani H, Grimes G, Wood A, et al. Psip1/p52 regulates posterior Hoxa genes through activation of lncRNA Hottip. PLoS Genet. 2017;13:e1006677 pubmed publisher
    ..knockdown and knockout approaches we show that Hottip expression is required for activation of the 5' Hoxa genes (Hoxa13 and Hoxa10/11) and for retaining Mll1 at the 5' end of Hoxa...
  72. Kadota M, Hara Y, Tanaka K, Takagi W, Tanegashima C, Nishimura O, et al. CTCF binding landscape in jawless fish with reference to Hox cluster evolution. Sci Rep. 2017;7:4957 pubmed publisher
    ..We analyzed CTCF binding inside Hox clusters, which revealed a reinforcement of CTCF binding in the region spanning Hox1-4 genes that is unique to lamprey...
  73. Cao L, Chen C, Leng Y, Yan L, Wang S, Zhang X, et al. A missense mutation of HOXA13 underlies hand-foot-genital syndrome in a Chinese family. J Genet. 2017;96:647-652 pubmed
    ..HFGS is caused by mutations in the HOXA13 gene...
  74. Debeer P, Bacchelli C, Scambler P, De Smet L, Fryns J, Goodman F. Severe digital abnormalities in a patient heterozygous for both a novel missense mutation in HOXD13 and a polyalanine tract expansion in HOXA13. J Med Genet. 2002;39:852-6 pubmed
  75. Doodnath R, Wride M, Puri P. The spatio-temporal patterning of Hoxa9 and Hoxa13 in the developing zebrafish enteric nervous system. Pediatr Surg Int. 2012;28:115-21 pubmed publisher
    ..Hoxa9 and Hoxa13 mutations have been discovered in patients with Hirschsprung's disease (HD)...
  76. Wang S, Wuputra K, Liu C, Lin Y, Chen Y, Chai C, et al. Oncogenic function of the homeobox A13-long noncoding RNA HOTTIP-insulin growth factor-binding protein 3 axis in human gastric cancer. Oncotarget. 2016;7:36049-36064 pubmed publisher
    ..Increased expression of homeobox A13 (HoxA13) and its downstream cascades was significant for the tumorigenic activity of CS12 cells, and was associated with ..
  77. Li Y, Li H, Xie N, Chen R, Lee A, Slater D, et al. HoxA10 and HoxA11 Regulate the Expression of Contraction-Associated Proteins and Contribute to Regionalized Myometrium Phenotypes in Women. Reprod Sci. 2018;25:44-50 pubmed publisher
    ..We have previously reported that the homeobox protein A13 (HoxA13) is highly expressed in the LUS and can enhance the expression of contraction-associated proteins (CAPs)...
  78. Lin C, Wang Y, Zhang S, Yu L, Guo C, Xu H. Transcriptional and posttranscriptional regulation of HOXA13 by lncRNA HOTTIP facilitates tumorigenesis and metastasis in esophageal squamous carcinoma cells. Oncogene. 2017;36:5392-5406 pubmed publisher
    ..In this study, we investigated the role of HOTTIP in ESCC and observed that HOTTIP/HOXA13 was upregulated in ESCC and promoted cell proliferation and metastasis in vivo and in vitro...
  79. Mortlock D, Sateesh P, Innis J. Evolution of N-terminal sequences of the vertebrate HOXA13 protein. Mamm Genome. 2000;11:151-8 pubmed
    ..To investigate the evolution of the HOXA13 protein and to identify conserved residues in the N-terminal region of the protein with potential functional ..
  80. Ekici A, Strissel P, Oppelt P, Renner S, Brucker S, Beckmann M, et al. HOXA10 and HOXA13 sequence variations in human female genital malformations including congenital absence of the uterus and vagina. Gene. 2013;518:267-72 pubmed publisher
    ..The homeobox (HOX) genes HOXA10 and HOXA13 are involved in the development of human genitalia...
  81. Ma R, Shen L, Chen K. Coexpression of ANXA2, SOD2 and HOXA13 predicts poor prognosis of esophageal squamous cell carcinoma. Oncol Rep. 2014;31:2157-64 pubmed publisher
    ..Previously, we found that the homeobox A13 gene (HOXA13) plays a crucial role in the carcinogenesis of ESCC and both Annexin A2 (ANXA2) and superoxide dismutase 2 (SOD2) ..
  82. Li H, Yu Y, Shi Y, Fazli L, Slater D, Lye S, et al. HoxA13 Stimulates Myometrial Cells to Secrete IL-1β and Enhance the Expression of Contraction-Associated Proteins. Endocrinology. 2016;157:2129-39 pubmed publisher
    ..The HoxA13 gene is highly expressed in the lower uterine segment before term labor and regulates the regionalization of ..
  83. B Shcherban A, A Salina E. Dataset of the HOX1 gene sequences of the wheat polyploids and their diploid relatives. Data Brief. 2018;16:147-153 pubmed publisher
    ..The sequencing data used here is available at DDBJ/EMBL/GenBank under the accession numbers MG000630-MG000698...
  84. Taketani T, Taki T, Ono R, Kobayashi Y, Ida K, Hayashi Y. The chromosome translocation t(7;11)(p15;p15) in acute myeloid leukemia results in fusion of the NUP98 gene with a HOXA cluster gene, HOXA13, but not HOXA9. Genes Chromosomes Cancer. 2002;34:437-43 pubmed
    ..We report here a novel NUP98 partner gene, HOXA13, in a patient with de novo AML having t(7;11)(p15;p15)...
  85. Utsch B, Kaya A, Ozburun A, Lentze M, Albers N, Ludwig M. Exclusion of WTAP and HOXA13 as candidate genes for isolated hypospadias. Scand J Urol Nephrol. 2003;37:498-501 pubmed
    ..Nevertheless, the etiology of hypospadias is unknown in 70% of cases. As mutations in the homeobox gene A13 (HOXA13) were all found to be associated with hypospadias in affected males, some types of mutation may solely lead to the ..
  86. Garcia Barcelo M, Miao X, Lui V, So M, Ngan E, Leon T, et al. Correlation between genetic variations in Hox clusters and Hirschsprung's disease. Ann Hum Genet. 2007;71:526-36 pubmed
    ..Genetic interactions were found between two HOX loci (5'-HOXA13 and 3'UTR-HOXB7) and the RET loci tested...
  87. Rinn J, Wang J, Allen N, Brugmann S, Mikels A, Liu H, et al. A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev. 2008;22:303-7 pubmed publisher
    ..The distal-specific gene HOXA13 is continually required to maintain the distal-specific transcriptional program in adult fibroblasts, including ..
  88. Yan W, Shen L, Gu Z, Chen K. [Up-regulation of HOXA13 in esophageal squamous cell carcinoma of stage IIa and its effect on the prognosis]. Zhonghua Wei Chang Wai Ke Za Zhi. 2009;12:20-3 pubmed
    To investigate the expression of HOXA13 gene in stage-II(a esophageal squamous cell carcinoma(ESCC), and to evaluate its relationship with clinicopathological characteristics and prognosis...
  89. Gu Z, Shen L, Wang H, Chen X, Li Y, Ning T, et al. HOXA13 promotes cancer cell growth and predicts poor survival of patients with esophageal squamous cell carcinoma. Cancer Res. 2009;69:4969-73 pubmed publisher
    ..Here, we investigated whether inhibition of HOXA13, a member of the homeobox genes, was sufficient to affect the proliferation of esophageal cancer cells in vitro ..
  90. Chang S, Liu J, Guo S, He S, Qiu G, Lu J, et al. HOTTIP and HOXA13 are oncogenes associated with gastric cancer progression. Oncol Rep. 2016;35:3577-85 pubmed publisher
    ..Moreover, downregulation of HOTTIP led to decreased expression of homeobox protein Hox-A13 (HOXA13) in gastric cancer cell lines. HOXA13 was involved in HOTTIP?induced malignant phenotypes of gastric cancer cells...
  91. Peng L, He Q, Li X, Shuai L, Chen H, Li Y, et al. HOXA13 exerts a beneficial effect in albumin-induced epithelial-mesenchymal transition via the glucocorticoid receptor signaling pathway in human renal tubular epithelial cells. Mol Med Rep. 2016;14:271-6 pubmed publisher
    ..Homeobox protein HOX?A13 (HOXA13) is a nuclear transcriptional factor that has been reported to be involved in renal fibrosis...