HOXA11

Summary

Gene Symbol: HOXA11
Description: homeobox A11
Alias: HOX1, HOX1I, RUSAT1, homeobox protein Hox-A11, homeo box 1I, homeobox protein HOXA11, homeobox protein Hox-1I
Species: human
Products:     HOXA11

Top Publications

  1. Connell K, Guess M, Chen H, Lynch T, Bercik R, Taylor H. HOXA11 promotes fibroblast proliferation and regulates p53 in uterosacral ligaments. Reprod Sci. 2009;16:694-700 pubmed publisher
    ..Previously, we have shown that HOXA11 is necessary for the development of the USLs, is deficient in women with pelvic organ prolapse (POP) and regulates ..
  2. Taylor H, Igarashi P, Olive D, Arici A. Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium. J Clin Endocrinol Metab. 1999;84:1129-35 pubmed
    ..b>Hoxa11 is essential for implantation in the mouse...
  3. Shen W, Krishnan K, Lawrence H, Largman C. The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol Cell Biol. 2001;21:7509-22 pubmed
  4. Williams T, Williams M, Innis J. Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction. Dev Biol. 2005;277:457-71 pubmed
  5. Apostolidou S, Hadwin R, Burnell M, Jones A, Baff D, Pyndiah N, et al. DNA methylation analysis in liquid-based cytology for cervical cancer screening. Int J Cancer. 2009;125:2995-3002 pubmed publisher
    ..Using quantitative methylation-specific PCR on 28 genes, we found SOX1, HOXA11 and CADM1 to significantly discriminate between the groups analyzed (p<0.01)...
  6. Lynch V, Brayer K, Gellersen B, Wagner G. HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: towards inferring the core transcriptional regulators of decidual genes. PLoS ONE. 2009;4:e6845 pubmed publisher
    ..In addition, the functional non-equivalence of HoxA-11 and HoxA-10 with respect to PRL regulation suggests that these transcription factors regulate distinct sets of target genes during decidualization. ..
  7. Mucenski M, Mahoney R, Adam M, Potter A, Potter S. Single cell RNA-seq study of wild type and Hox9,10,11 mutant developing uterus. Sci Rep. 2019;9:4557 pubmed publisher
    ..The Hoxa10 and Hoxa11 genes have previously been shown to play essential roles in uterus development and function...
  8. Mazzoni E, Mahony S, Peljto M, Patel T, Thornton S, McCuine S, et al. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nat Neurosci. 2013;16:1191-1198 pubmed publisher
    ..neural progenitors with retinoic acid leads to activation and binding of retinoic acid receptors (RARs) to the Hox1-Hox5 chromatin domains, which is followed by a rapid domain-wide removal of H3K27me3 and acquisition of cervical ..
  9. Cheng Y, Jutooru I, Chadalapaka G, Corton J, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 2015;6:10840-52 pubmed
    ..HOTTIP does not regulate HOXA13 but plays a role in regulation of several other HOX genes including HOXA10, HOXB2, HOXA11, HOXA9 and HOXA1...

More Information

Publications128 found, 100 shown here

  1. Lopez J, Angulo J, Martin A, Sanchez Chapado M, González Corpas A, Colás B, et al. A DNA hypermethylation profile reveals new potential biomarkers for the evaluation of prognosis in urothelial bladder cancer. APMIS. 2017;125:787-796 pubmed publisher
    ..On the other hand, in high-grade invasive disease hypermethylation of CSPG2, HOXA11, HOXA9, HS3ST2, SOX1, and TWIST1 was associated with muscle invasiveness...
  2. Chen J, Zhou L, Xu S, Zheng Y, Wan Y, Hu C. Overexpression of lncRNA HOXA11-AS promotes cell epithelial-mesenchymal transition by repressing miR-200b in non-small cell lung cancer. Cancer Cell Int. 2017;17:64 pubmed publisher
    ..crucial roles in human cancers progression, the study aimed to detect the association between long non-coding RNA HOXA11-AS and epithelial-mesenchymal transition (EMT) process in non-small cell lung cancer (NSCLC)...
  3. Yu J, Hong J, Kang J, Liao L, Li C. Promotion of LncRNA HOXA11-AS on the proliferation of hepatocellular carcinoma by regulating the expression of LATS1. Eur Rev Med Pharmacol Sci. 2017;21:3402-3411 pubmed
    To investigate the expression levels of lncRNA HOXA11-AS in HCC tissues and cells, and to explore its biological role in the development and progression of HCC...
  4. Guo S, Li Z, Yan L, Sun Y, Feng Y. GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity. Drug Des Devel Ther. 2018;12:1621-1631 pubmed publisher
    ..35 versus 8 ± 0.56; P = 0.04). The uterine expression levels of Hoxa10, Hoxa11, Lif and integrin b3 mRNA and protein were decreased in the adenomyosis group, and were significantly increased ..
  5. Dokmeci F, Teksen F, Cetinkaya S, Ozkan T, Kaplan F, Kose K. Expressions of homeobox, collagen and estrogen genes in women with uterine prolapse. Eur J Obstet Gynecol Reprod Biol. 2019;233:26-29 pubmed publisher
    ..We aimed to study the gene expression profiles of the genes HomeoboxA11 (HOXA11), HomeoboxA13 (HOXA13), Collagen Type I (COL1A), Collagen Type III (COL3A), estrogen receptor genes (ESR1 and ESR2)..
  6. Xu C, Xiao L, Liu Y, Chen L, Zheng S, Zeng E, et al. The lncRNA HOXA11-AS promotes glioma cell growth and metastasis by targeting miR-130a-5p/HMGB2. Eur Rev Med Pharmacol Sci. 2019;23:241-252 pubmed publisher
    ..Transcription-Polymerase Chain Reaction (qRT-PCR) was used to determine the levels of HOMEOBOX A11 antisense RNA (HOXA11-AS) and miR-130a-5p in glioma tissues and cell lines. Short hairpin RNAs (shRNAs) targeting HOXA11-AS or pcDNA3...
  7. Laheri S, Ashary N, Bhatt P, Modi D. Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion. J Assist Reprod Genet. 2018;35:1419-1429 pubmed publisher
    ..cells reduced mRNA expression of ITGAV, ITGB3, ITGA5, HOXA10, LIF, and IL15; it increased the expression of HOXA11, MMP9, TIMP1, and TIMP3...
  8. Cunha G, Robboy S, Kurita T, Isaacson D, Shen J, Cao M, et al. Development of the human female reproductive tract. Differentiation. 2018;103:46-65 pubmed publisher
    ..markers are described during human female reproductive tract development (keratins, homeobox proteins (HOXA11 and ISL1), steroid receptors (estrogen receptor alpha and progesterone receptor), transcription factors and ..
  9. Xiong M, Zhang H, Jin L, Ai J, Huang Z, Zhu G. Association of controlled ovarian hyperstimulation treatment with down-regulation of key regulators involved in embryonic implantation in mice. J Huazhong Univ Sci Technolog Med Sci. 2011;31:535 pubmed publisher
    ..Homeobox A11 (Hoxa11), Meis homeobox 1 (Meis1), cadherin 1 (Cdh1), and catenin beta 1 (Ctnnb1) are well known to be involved in ..
  10. Jin Q, Huang L, Zhao T, Yao X, Lin L, Teng Y, et al. HOXA11-AS regulates diabetic arteriosclerosis-related inflammation via PI3K/AKT pathway. Eur Rev Med Pharmacol Sci. 2018;22:6912-6921 pubmed publisher
    This study aims to explore whether homeobox A11 antisense RNA (HOXA11-AS) could regulate inflammation induced by diabetic arteriosclerosis (DAA) via PI3K/AKT pathway...
  11. Kherdjemil Y, Lalonde R, Sheth R, Dumouchel A, de Martino G, Pineault K, et al. Evolution of Hoxa11 regulation in vertebrates is linked to the pentadactyl state. Nature. 2016;539:89-92 pubmed publisher
    ..Here we show that the mutually exclusive expression of the mouse genes Hoxa11 and Hoxa13, which were previously proposed to be involved in the origin of the tetrapod limb, is required for the ..
  12. Sun Y, Zeng C, Gan S, Li H, Cheng Y, Chen D, et al. LncRNA HOTTIP-Mediated HOXA11 Expression Promotes Cell Growth, Migration and Inhibits Cell Apoptosis in Breast Cancer. Int J Mol Sci. 2018;19: pubmed publisher
    ..Using gain-and-loss-of experiments in vitro and in vivo, we observed the marked upregulation of HOTTIP/HOXA11 in the breast cancer cell line, MCF-7, and the downregulation of HOTTIP or HOXA11, which might inhibit cell ..
  13. Parker H, Pushel I, Krumlauf R. Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest. Dev Biol. 2018;444 Suppl 1:S67-S78 pubmed publisher
    ..We highlight early roles for Hox1 genes in cNCC specification, proposing that this may be achieved, in part, by regulation of the balance between ..
  14. Leite Castro J, Beviano V, Rodrigues P, Freitas R. HoxA Genes and the Fin-to-Limb Transition in Vertebrates. J Dev Biol. 2016;4: pubmed publisher
    ..Within these genes, HoxA11 and HoxA13 were proposed to have played an essential role in the enigmatic evolutionary transition from ..
  15. Godfrey T, Wildman B, Beloti M, Kemper A, Ferraz E, Roy B, et al. The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation. J Biol Chem. 2018;293:17646-17660 pubmed publisher
    ..cluster in preosteoblasts decreased and increased, respectively, the expression of the proteins HOXA5, HOXA10, and HOXA11; these proteins' mRNAs exhibited significant binding with the miR-23a cluster miRNAs, and miRNA 3'-UTR reporter ..
  16. Yao Y, Chen X, Lu S, Zhou C, Xu G, Yan Z, et al. Circulating Long Noncoding RNAs as Biomarkers for Predicting Head and Neck Squamous Cell Carcinoma. Cell Physiol Biochem. 2018;50:1429-1440 pubmed publisher
    ..After the risk score analysis including a multistage validation, we identified three lncRNAs, namely, HOXA11-AS, LINC00964 and MALAT1, which were up-regulated in the plasma of HNSCC patients compared with those in healthy ..
  17. Yim G, Kim H, Kim L, Kim S, Kim S, Nam E, et al. Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer. Cancer Res Treat. 2017;49:656-668 pubmed publisher
    ..lncRNAs) is only partially understood; therefore, in this study, we investigated the expression of the novel HOXA11 antisense (HOXA11as) lncRNA and its oncogenic role in serous ovarian cancer (SOC)...
  18. Fujiwara S, Canestro C. Reporter Analyses Reveal Redundant Enhancers that Confer Robustness on Cis-Regulatory Mechanisms. Adv Exp Med Biol. 2018;1029:69-79 pubmed publisher
    Reporter analyses of Hox1 and Brachyury (Bra) genes have revealed examples of redundant enhancers that provide regulatory robustness...
  19. Shen X, Bai H, Zhu H, Yan Q, Yang Y, Yu W, et al. Long Non-Coding RNA MEG3 Functions as a Competing Endogenous RNA to Regulate HOXA11 Expression by Sponging miR-181a in Multiple Myeloma. Cell Physiol Biochem. 2018;49:87-100 pubmed publisher
    ..Furthermore, as the target mRNA of miR-181a, homeobox gene A11(HOXA11) could be positively regulated by MEG3 through sponging miR-181a competitively in vitro...
  20. Shin Y, Jeon Y, Jung N, Park J, Park H, Jung S. Substrate-specific gene expression profiles in different kidney cell types are associated with Fabry disease. Mol Med Rep. 2015;12:5049-57 pubmed publisher
    ..In the SV40 MES 13 cells, the DLL1, F8, and HOXA11 genes were downregulated, and FOXP2 was upregulated by treatment with Gb3 or lyso‑Gb3...
  21. Wang Q, Zhang J, Liu Y, Zhang W, Zhou J, Duan R, et al. A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma. Cancer Lett. 2016;373:251-9 pubmed publisher
    ..Here, we found that a novel lncRNA, HOXA11-AS, was the antisense transcript of the HOX11 gene...
  22. Xu Y, Wu D, Liu J, Huang S, Zuo Q, Xia X, et al. Downregulated lncRNA HOXA11-AS Affects Trophoblast Cell Proliferation and Migration by Regulating RND3 and HOXA7 Expression in PE. Mol Ther Nucleic Acids. 2018;12:195-206 pubmed publisher
    The long noncoding RNA HOXA11-AS displays abnormal expression in numerous human diseases. However, its function and biological mechanisms remain unclear in preeclampsia (PE)...
  23. Sun M, Nie F, Wang Y, Zhang Z, Hou J, He D, et al. LncRNA HOXA11-AS Promotes Proliferation and Invasion of Gastric Cancer by Scaffolding the Chromatin Modification Factors PRC2, LSD1, and DNMT1. Cancer Res. 2016;76:6299-6310 pubmed
    ..Here we report the gastric cancer-associated lncRNA HOXA11-AS as a key regulator of gastric cancer development and progression...
  24. Durston A, Zhu K. A time space translation hypothesis for vertebrate axial patterning. Semin Cell Dev Biol. 2015;42:86-93 pubmed publisher
    ..Hox functionality is implicated because knocking out the Hox1 paralogue group not only disrupts expression of Hox1 genes but also of the whole spatially collinear axial Hox ..
  25. Luo L, Yang X, Takihara Y, Knoetgen H, Kessel M. The cell-cycle regulator geminin inhibits Hox function through direct and polycomb-mediated interactions. Nature. 2004;427:749-53 pubmed
    ..By establishing competitive regulation, geminin functions as a coordinator of developmental and proliferative control. ..
  26. Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller D, et al. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clin Cancer Res. 2014;20:6504-16 pubmed publisher
    ..drivers of ovarian cancer cisplatin resistance (MLH1 and ZIC1), differentiation-associated genes (HOXA10 and HOXA11), and transcription factors (STAT5B)...
  27. Chen J, Fu Z, Ji C, Gu P, Xu P, Yu N, et al. Systematic gene microarray analysis of the lncRNA expression profiles in human uterine cervix carcinoma. Biomed Pharmacother. 2015;72:83-90 pubmed publisher
    ..0) in cervix carcinoma compared to the normal cervical tissue. Furthermore, we found HOXA11-AS might participate in cervix carcinogenesis by regulating HOXA11, which is involved in regulating biological ..
  28. Brinkmeier M, Geister K, Jones M, Waqas M, Maillard I, Camper S. The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice. Biol Reprod. 2015;93:121 pubmed publisher
    ..Specifically, expression of Hoxa11 and Hoxd10 are altered in the epididymis of Ash1l mutant males and Hoxa10 is reduced in the uterus of Ash1l mutant ..
  29. Tas E, Sebastian J, Madan Khetarpal S, Sweet P, Yatsenko A, Pollock N, et al. Familial deletion of the HOXA gene cluster associated with Hand-Foot-Genital syndrome and phenotypic variability. Am J Med Genet A. 2017;173:221-224 pubmed publisher
    ..Our expression studies did not support the hypothesis of an imprinted status of the HOXA2, HOXA3, HOXA5, and HOXA11 genes in peripheral blood. To our knowledge, this is the first familial 7p15.2 deletion...
  30. Chau Y, Pando S, Taylor H. HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium. J Clin Endocrinol Metab. 2002;87:2674-80 pubmed
    b>Hoxa11 is an essential regulator of embryonic uterine development and the cyclic development of the adult uterine endometrium. Hoxa11 is required for female fertility, as evidenced by targeted mutation...
  31. Zhang R, Zhang T, Zhai G, Guo X, Qin Y, Gan T, et al. Evaluation of the HOXA11 level in patients with lung squamous cancer and insights into potential molecular pathways via bioinformatics analysis. World J Surg Oncol. 2018;16:109 pubmed publisher
    This study was carried out to discover the underlying role that HOXA11 plays in lung squamous cancer (LUSC) and uncover the potential corresponding molecular mechanisms and functions of HOXA11-related genes...
  32. Nagy I, Kovács K, Rákhely G, Maróti G. HupO, a Novel Regulator Involved in Thiosulfate-Responsive Control of HupSL [NiFe]-Hydrogenase Synthesis in Thiocapsa roseopersicina. Appl Environ Microbiol. 2016;82:2039-2049 pubmed publisher
    ..purple sulfur bacterium Thiocapsa roseopersicina harbors four functional [NiFe]-hydrogenases: HynSL, HupSL, Hox1, and Hox2...
  33. Neufeld S, Wang F, Cobb J. Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. Genetics. 2014;198:1117-26 pubmed publisher
    ..associated spatial expression dynamics, with Shox2 expression restricted to the proximal limb along with Hoxd9 and Hoxa11 expression, juxtaposing the distal expression of Hoxa13 and Hoxd13...
  34. Kjosness K, Hines J, Lovejoy C, Reno P. The pisiform growth plate is lost in humans and supports a role for Hox in growth plate formation. J Anat. 2014;225:527-38 pubmed publisher
    ..Hox expression and growth plate formation, and could explain the severe effects on the pisiform observed in Hoxa11 and Hoxd11 knockout mice...
  35. Eun Kwon H, Taylor H. The role of HOX genes in human implantation. Ann N Y Acad Sci. 2004;1034:1-18 pubmed
    ..HOXA10 and HOXA11 expression increases during the menstrual cycle, increasing drastically in the midluteal phase, at the time of ..
  36. Sasakura Y. The Enhancer Trap in Ciona. Adv Exp Med Biol. 2018;1029:121-129 pubmed publisher
    ..the presence of enhancers sensitive to the orientation of the gene that they regulate, and the functions of the Hox1 gene have been revealed...
  37. Liu Z, Chen Z, Fan R, Jiang B, Chen X, Chen Q, et al. Over-expressed long noncoding RNA HOXA11-AS promotes cell cycle progression and metastasis in gastric cancer. Mol Cancer. 2017;16:82 pubmed publisher
    ..In our previous study, we found that GC associated lncRNA HOXA11-AS is significantly upregulated in GC tissues...
  38. Pineault K, Swinehart I, Garthus K, Ho E, Yao Q, Schipani E, et al. Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation. Biol Open. 2015;4:1538-48 pubmed publisher
    ..Loss of function of both Hoxa11 and Hoxd11 results in severe malformation of the forelimb zeugopod...
  39. Uzkudun M, Marcon L, Sharpe J. Data-driven modelling of a gene regulatory network for cell fate decisions in the growing limb bud. Mol Syst Biol. 2015;11:815 pubmed publisher
    ..First, we map the expression patterns of the PD markers Meis1, Hoxa11 and Hoxa13 into a dynamic description of the tissue movements that drive limb morphogenesis...
  40. Niihori T, Ouchi Uchiyama M, Sasahara Y, Kaneko T, Hashii Y, Irie M, et al. Mutations in MECOM, Encoding Oncoprotein EVI1, Cause Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia. Am J Hum Genet. 2015;97:848-54 pubmed publisher
    ..A heterozygous HOXA11 mutation has been identified in two unrelated families as a cause of RUSAT...
  41. Nnamani M, Ganguly S, Erkenbrack E, Lynch V, Mizoue L, Tong Y, et al. A Derived Allosteric Switch Underlies the Evolution of Conditional Cooperativity between HOXA11 and FOXO1. Cell Rep. 2016;15:2097-2108 pubmed publisher
    ..Here, we investigate the molecular mechanisms for the origin of a derived functional interaction between two TFs, HOXA11 and FOXO1...
  42. Martinez Abadias N, Mateu R, Niksic M, Russo L, Sharpe J. Geometric Morphometrics on Gene Expression Patterns Within Phenotypes: A Case Example on Limb Development. Syst Biol. 2016;65:194-211 pubmed publisher
    ..patterns of the limb bud shape with the expression patterns of two relevant genes for limb morphogenesis, Hoxa11 and Hoxa13...
  43. Chen J, Hoffman J, Arora R, Perrone L, Gonzalez Gomez C, Vo K, et al. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016;105:501-10.e1 pubmed publisher
    ..05) stromal-specific genes COL6A3, HOXA11, MMP2, PDGFRB, and WNT5A...
  44. Kim H, Eoh K, Kim L, Nam E, Yoon S, Kim K, et al. The long noncoding RNA HOXA11 antisense induces tumor progression and stemness maintenance in cervical cancer. Oncotarget. 2016;7:83001-83016 pubmed publisher
    ..However, whether HOXA11 antisense (HOXA11-AS) is involved in cervical cancer remains to be elucidated...
  45. Raines A, Magella B, Adam M, Potter S. Key pathways regulated by HoxA9,10,11/HoxD9,10,11 during limb development. BMC Dev Biol. 2015;15:28 pubmed publisher
    ..Hoxa9,10,11 (-/-) /Hoxd9,10,11 (-/-) mutant mice show a reduced ulna and radius that is more severe than seen in Hoxa11 (-/-)/Hoxd11 (-/-) mice, indicating a minor role for the flanking Hox9,10 genes in zeugopod development, as well ..
  46. Fritsch M, Wollesen T, de Oliveira A, Wanninger A. Unexpected co-linearity of Hox gene expression in an aculiferan mollusk. BMC Evol Biol. 2015;15:151 pubmed publisher
    ..In A. crinita the Hox genes Acr-Hox1-5, Hox7 and Post2 are expressed in a co-linear pattern along the antero-posterior axis, but not in molluscan-..
  47. Li T, Xu C, Cai B, Zhang M, Gao F, Gan J. Expression and clinicopathological significance of the lncRNA HOXA11-AS in colorectal cancer. Oncol Lett. 2016;12:4155-4160 pubmed
    b>HOXA11 antisense RNA (HOXA11-AS) is a long non-coding RNA (lncRNA) that is important in determining cancer progression. HOXA11-AS was recently identified as a novel biomarker in lung cancer progression...
  48. Zhu Y, Cheng Z, Wang J, Liu B, Cheng L, Chen B, et al. A novel mutation of HOXA11 in a patient with septate uterus. Orphanet J Rare Dis. 2017;12:178 pubmed publisher
    The etiology of Müllerian duct anomalies (MDAs) is poorly understood at present. The HOXA11 gene is crucial for the development of the Müllerian duct...
  49. Bourdiec A, Ahmad S, Lachhab A, Akoum A. Regulation of inflammatory and angiogenesis mediators in a functional model of decidualized endometrial stromal cells. Reprod Biomed Online. 2016;32:85-95 pubmed publisher
    ..Additionally, endometrial cells showed increased expression of homeobox HOXA10 and HOXA11 and LIFR, which are known to be involved in endometrial embryo receptivity...
  50. Gonzalez P, Uhlinger K, Lowe C. The Adult Body Plan of Indirect Developing Hemichordates Develops by Adding a Hox-Patterned Trunk to an Anterior Larval Territory. Curr Biol. 2017;27:87-95 pubmed publisher
    ..The larval ectoderm has an anterior molecular signature, while most of the trunk, defined by the expression of hox1-7, is absent...
  51. Zhang Y, He R, Dang Y, Zhang X, Wang X, Huang S, et al. Comprehensive analysis of the long noncoding RNA HOXA11-AS gene interaction regulatory network in NSCLC cells. Cancer Cell Int. 2016;16:89 pubmed publisher
    ..However, the possible molecular mechanisms underlying the effects of the long noncoding RNA HOXA11-AS (HOXA11 antisense RNA) in NSCLC are unknown...
  52. Sun X, Wang Q, Guo B, Liu X, Wang B. Identification of skin-related lncRNAs as potential biomarkers that involved in Wnt pathways in keloids. Oncotarget. 2017;8:34236-34244 pubmed publisher
    ..As a result, four lncRNAs including CACNA1G-AS1, HOXA11-AS, LINC00312 and RP11-91I11...
  53. Saxena S, Yuan P, Dhar S, Senga T, Takeda D, Robinson H, et al. A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. Mol Cell. 2004;15:245-58 pubmed
    ..It also directly inhibits the HoxA11 transcription factor...
  54. Reddy P, Unni M, Gungi A, Agarwal P, Galande S. Evolution of Hox-like genes in Cnidaria: Study of Hydra Hox repertoire reveals tailor-made Hox-code for Cnidarians. Mech Dev. 2015;138 Pt 2:87-96 pubmed publisher
    ..Phylogenetic analysis of these genes shows bilaterian counterparts of Hox1, Gsx and Mox...
  55. Ma W, Li Y, Wang M, Li H, Su T, Li Y, et al. Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han. PLoS ONE. 2015;10:e0130202 pubmed publisher
    ..Seventeen candidate loci in the AMH, PBX1, WNT4, WNT7A, WNT9B, HOXA10, HOXA11, LHXA1 and GALT genes were genotyped using the Sequenom MassARRAY iPLEX platform...
  56. Nakayama S, Satou K, Orito W, Ogasawara M. Ordered expression pattern of Hox and ParaHox genes along the alimentary canal in the ascidian juvenile. Cell Tissue Res. 2016;365:65-75 pubmed publisher
    ..Expression of Hox1 to Hox4 is restricted to the posterior region of pharyngeal derivatives...
  57. Bouba I, Siomou E, Stefanidis C, Emmanouilidou A, Galidi A, Hatzi E, et al. Absence of mutations in the HOXA11 and HOXD11 genes in children with congenital renal malformations. Pediatr Nephrol. 2009;24:1569-72 pubmed publisher
    ..b>Hoxa11/Hoxd11 double mutant mice demonstrate renal agenesis or hypoplasia...
  58. Papageorgiou S. Physical Forces May Cause the HoxD Gene Cluster Elongation. Biology (Basel). 2017;6: pubmed publisher
    Hox gene collinearity was discovered be Edward B. Lewis in 1978. It consists of the Hox1, Hox2, Hox3 ordering of the Hox genes in the chromosome from the telomeric to the centromeric side of the chromosome...
  59. Naqvi H, Mamillapalli R, Krikun G, Taylor H. Endometriosis Located Proximal to or Remote From the Uterus Differentially Affects Uterine Gene Expression. Reprod Sci. 2016;23:186-91 pubmed publisher
    ..The expression of several genes that are involved in endometrial receptivity (homeobox A10 [Hoxa10], homeobox A11 [Hoxa11], insulin-like growth factor binding protein 1 [Igfbp1], Kruppel-like factor 9 [Klf9], and progesterone receptor [..
  60. Richards E, Permuth Wey J, Li Y, Chen Y, Coppola D, Reid B, et al. A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer. Oncotarget. 2015;6:34745-57 pubmed publisher
    ..The 5-prime end of HOXA includes three long non-coding RNAs (lncRNAs) (HOXA10-AS, HOXA11-AS, and HOTTIP) that are underexplored in epithelial ovarian cancer (EOC)...
  61. Li Y, Kang K, Krahn J, Croutwater N, Lee K, Umbach D, et al. A comprehensive genomic pan-cancer classification using The Cancer Genome Atlas gene expression data. BMC Genomics. 2017;18:508 pubmed publisher
    ..Genes that were differentially expressed between genders included BNC1, FAT2, FOXA1, and HOXA11. FOXA1 has been shown to play a role for sexual dimorphism in liver cancer...
  62. Zhang Y, Chen W, Gan T, Zhang X, Xie Z, Ye Z, et al. Clinical Significance and Effect of lncRNA HOXA11-AS in NSCLC: A Study Based on Bioinformatics, In Vitro and in Vivo Verification. Sci Rep. 2017;7:5567 pubmed publisher
    b>HOXA11 antisense RNA (HOXA11-AS) has been shown to be involved in tumorigenesis and development of different cancers. However, the role of HOXA11-AS in non-small cell lung cancer (NSCLC) remains unclear...
  63. Wollesen T, Scherholz M, Rodríguez Monje S, Redl E, Todt C, Wanninger A. Brain regionalization genes are co-opted into shell field patterning in Mollusca. Sci Rep. 2017;7:5486 pubmed publisher
    The 'brain regionalization genes' Six3/6, Otx, Pax2/5/8, Gbx, and Hox1 are expressed in a similar fashion in the deuterostome, ecdysozoan, and the cephalopod brain, questioning whether this holds also true for the remaining Mollusca...
  64. Wang L, Luo H, Zhu Z, Wang J. Expression of HOXA11 gene in human endometrium. Am J Obstet Gynecol. 2004;191:767-72 pubmed
    This study was conducted to examine HOXA11 gene expression in the human endometrium during normal menstrual cycle...
  65. Luke M, Sui G, Liu H, Shi Y. Yin Yang 1 physically interacts with Hoxa11 and represses Hoxa11-dependent transcription. J Biol Chem. 2006;281:33226-32 pubmed
    ..Although ectopic expression of Hoxa11 enhanced target promoter activity, overexpression of YY1 repressed this effect, which was abrogated by YY1 siRNA ..
  66. Liatsikos S, Grimbizis G, Georgiou I, Papadopoulos N, Lazaros L, Bontis J, et al. HOX A10 and HOX A11 mutation scan in congenital malformations of the female genital tract. Reprod Biomed Online. 2010;21:126-32 pubmed publisher
    ..No subject showed a plausible causative mutation in HOX A10 or HOX A11; the sole variant observed (P38R) found in a patient with septate uterus was also present in her clinically normal mother. ..
  67. Szczepańska M, Wirstlein P, Skrzypczak J. [HOXA11 gene expression in women with and without impaired infertility]. Ginekol Pol. 2010;81:414-21 pubmed
    ..The purpose of this study was to examine the expression pattern of HOXA11 and expression and localization of its protein product in the endometrium of women with endometriosis, idiopathic ..
  68. Yoshida K, Nakahata A, Treen N, Sakuma T, Yamamoto T, Sasakura Y. Hox-mediated endodermal identity patterns pharyngeal muscle formation in the chordate pharynx. Development. 2017;144:1629-1634 pubmed publisher
    ..Here, we show that Hox1 is essential for the establishment of AP axial identity of the endostyle, a major structure of the pharyngeal ..
  69. Cui M, Wang J, Li Q, Zhang J, Jia J, Zhan X. Long non-coding RNA HOXA11-AS functions as a competing endogenous RNA to regulate ROCK1 expression by sponging miR-124-3p in osteosarcoma. Biomed Pharmacother. 2017;92:437-444 pubmed publisher
    ..this study was to explore the critical role of lncRNA HOXA11-AS in osteosarcoma (OS) progression...
  70. Li N, Yang M, Shi K, Li W. Long non-coding RNA HOXA11-AS in human cancer: A meta-analysis. Clin Chim Acta. 2017;474:165-170 pubmed publisher
    Homeobox A11 antisense (HOXA11-AS), a newly identified lncRNA, is up-regulated in various carcinomas...
  71. Miano J, Firulli A, Olson E, Hara P, Giachelli C, Schwartz S. Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells. Proc Natl Acad Sci U S A. 1996;93:900-5 pubmed
    ..muscle cell library; however, five nonparalogous homeobox genes were uncovered from the fetal library (HoxA5, HoxA11, HoxB1, HoxB7, and HoxC9)...
  72. Thompson A, Nguyen L. Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation. Nat Genet. 2000;26:397-8 pubmed
  73. Cui Y, Gao D, Linghu E, Zhan Q, Chen R, Brock M, et al. Epigenetic changes and functional study of HOXA11 in human gastric cancer. Epigenomics. 2015;7:201-13 pubmed publisher
    To examine epigenetic changes and the function of HOXA11 in human gastric cancer (GC). Seven GC cell lines, five cases of normal gastric mucosa and 112 cases primary GC samples were used in this study...
  74. DU H, Taylor H. The Role of Hox Genes in Female Reproductive Tract Development, Adult Function, and Fertility. Cold Spring Harb Perspect Med. 2015;6:a023002 pubmed publisher
    ..HOX genes are also essential regulators of adult endometrial development. Regulated HOXA10 and HOXA11 expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 expression leads to decreased ..
  75. Li Y, Li H, Xie N, Chen R, Lee A, Slater D, et al. HoxA10 and HoxA11 Regulate the Expression of Contraction-Associated Proteins and Contribute to Regionalized Myometrium Phenotypes in Women. Reprod Sci. 2018;25:44-50 pubmed publisher
    ..Here, we show that in contrast to HoxA13, HoxA10 and HoxA11 genes are expressed at significantly higher levels in myometrium tissues and primary myocytes from the FUN...
  76. Li W, Jia G, Qu Y, Du Q, Liu B, Liu B. Long Non-Coding RNA (LncRNA) HOXA11-AS Promotes Breast Cancer Invasion and Metastasis by Regulating Epithelial-Mesenchymal Transition. Med Sci Monit. 2017;23:3393-3403 pubmed
    BACKGROUND To detect the expression of lncRNA HOXA11-AS and its biological effect in breast cancer...
  77. Yu W, Peng W, Jiang H, Sha H, Li J. LncRNA HOXA11-AS promotes proliferation and invasion by targeting miR-124 in human non-small cell lung cancer cells. Tumour Biol. 2017;39:1010428317721440 pubmed publisher
    ..In this study, we found that HOXA11-AS expression was upregulated in non-small cell lung cancer tissues and cell lines...
  78. Fujino T, Suzuki A, Ito Y, Ohyashiki K, Hatano Y, Miura I, et al. Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15). Blood. 2002;99:1428-33 pubmed
    ..primer corresponding to the third helix of the homeodomain of HOXA demonstrated that NUP98 was fused in-frame to HOXA11 in the patient with CML and to HOXA13 in the patient with MDS...
  79. Williams T, Williams M, Heaton J, Gelehrter T, Innis J. Group 13 HOX proteins interact with the MH2 domain of R-Smads and modulate Smad transcriptional activation functions independent of HOX DNA-binding capability. Nucleic Acids Res. 2005;33:4475-84 pubmed
    ..we isolated the BMP-signaling effector Smad5, which interacted with the paralogous HOXD13 but not with HOXA11 or HOXA9, revealing unique interaction capabilities of the AbdB-like HOX proteins...
  80. Connell K, Guess M, Chen H, Andikyan V, Bercik R, Taylor H. HOXA11 is critical for development and maintenance of uterosacral ligaments and deficient in pelvic prolapse. J Clin Invest. 2008;118:1050-5 pubmed publisher
    ..We demonstrated here that HOXA11 was essential for organogenesis of the USL by showing that USLs were absent in Hoxa11-null mice...
  81. Li Z, Huang H, Li Y, Jiang X, Chen P, Arnovitz S, et al. Up-regulation of a HOXA-PBX3 homeobox-gene signature following down-regulation of miR-181 is associated with adverse prognosis in patients with cytogenetically abnormal AML. Blood. 2012;119:2314-24 pubmed publisher
    ..show that up-regulation of a gene signature composed of 4 potential miR-181 targets (including HOXA7, HOXA9, HOXA11, and PBX3), associated with down-regulation of miR-181 family members, is an independent predictor of adverse ..
  82. Jana S, Banerjee P, Mukherjee R, Chakravarty B, Chaudhury K. HOXA-11 mediated dysregulation of matrix remodeling during implantation window in women with endometriosis. J Assist Reprod Genet. 2013;30:1505-12 pubmed publisher
    ..The findings suggest that aberrant expression of HOXA-10 and -11 genes adversely affects endometrial remodelling and expression of receptivity markers. ..
  83. Jeon M, Kim E, Lee M, Kim H, Choi J, Chae H, et al. MicroRNA-30d and microRNA-181a regulate HOXA11 expression in the uterosacral ligaments and are overexpressed in pelvic organ prolapse. J Cell Mol Med. 2015;19:501-9 pubmed publisher
    ..factor that controls collagen metabolism and homoeostasis in the uterosacral ligaments (USLs), and the deficient HOXA11 signalling may contribute to alterations in the biochemical strength of the USLs, leading to pelvic organ prolapse ..
  84. Se Y, Kim S, Kim J, Kim J, Dho Y, Kim J, et al. Underexpression of HOXA11 Is Associated with Treatment Resistance and Poor Prognosis in Glioblastoma. Cancer Res Treat. 2017;49:387-398 pubmed publisher
    ..The underexpression of HOXA11 was identified as a consistent signature for a poor prognosis among the HOX genes...
  85. Wang L, Cui Y, Sheng J, Yang Y, Kuang G, Fan Y, et al. Epigenetic inactivation of HOXA11, a novel functional tumor suppressor for renal cell carcinoma, is associated with RCC TNM classification. Oncotarget. 2017;8:21861-21870 pubmed publisher
    Epigenetic inactivation of HOXA11, a putative tumor suppressor, is frequently observed in a number of solid tumors, but has not been described in RCC (renal cell carcinoma)...
  86. Lu Q, Zhao N, Zha G, Wang H, Tong Q, Xin S. LncRNA HOXA11-AS Exerts Oncogenic Functions by Repressing p21 and miR-124 in Uveal Melanoma. DNA Cell Biol. 2017;36:837-844 pubmed publisher
    ..The aim of this study was to explore the critical role of lncRNA HOXA11-AS in uveal melanoma (UM) progression...
  87. Cui Y, Yi L, Zhao J, Jiang Y. Long Noncoding RNA HOXA11-AS Functions as miRNA Sponge to Promote the Glioma Tumorigenesis Through Targeting miR-140-5p. DNA Cell Biol. 2017;36:822-828 pubmed publisher
    Long noncoding RNAs (lncRNAs) have been proved as important regulators in many diseases, including cancers. HOXA11 antisense RNA (HOXA11-AS) is a novel identified lncRNA associated with cancer progression...
  88. Cunha G, Kurita T, Cao M, Shen J, Robboy S, Baskin L. Response of xenografts of developing human female reproductive tracts to the synthetic estrogen, diethylstilbestrol. Differentiation. 2017;98:35-54 pubmed publisher
    ..of differentiation marker expression (KRT6, KRT7, KRT8, KRT10, KRT14, KRT19, ESR1, PGR, TP63, RUNX1, ISL1, HOXA11 and α-ACT2) were observed in xenografts grown in untreated hosts and mimicked observations of previously reported ..
  89. B Shcherban A, A Salina E. Dataset of the HOX1 gene sequences of the wheat polyploids and their diploid relatives. Data Brief. 2018;16:147-153 pubmed publisher
    ..The sequencing data used here is available at DDBJ/EMBL/GenBank under the accession numbers MG000630-MG000698...
  90. Potter S, Branford W. Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts. Mamm Genome. 1998;9:799-806 pubmed
    ..Given the significant differences in amino acid sequences of the homeodomains of different Hox genes, this observation argues for individual homeodomain functional specificity. ..
  91. Daftary G, Taylor H. Implantation in the human: the role of HOX genes. Semin Reprod Med. 2000;18:311-20 pubmed
    ..It has been discovered that HOX genes are expressed in the adult uterus. Two of them, Hoxa10 and Hoxa11, have been demonstrated to be necessary for uterine receptivity and implantation in mice...
  92. Speleman F, Cauwelier B, Dastugue N, Cools J, Verhasselt B, Poppe B, et al. A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias. Leukemia. 2005;19:358-66 pubmed
    ..Real time quantitative PCR analysis for all HOXA genes revealed high levels of HOXA10 and HOXA11 expression in all inv(7) positive cases...