HOXA10

Summary

Gene Symbol: HOXA10
Description: homeobox A10
Alias: HOX1, HOX1.8, HOX1H, homeobox protein Hox-A10, homeo box A10, homeobox protein 1H, homeobox protein HOXA10, homeobox protein Hox-1.8, homeobox protein Hox-1H
Species: human
Products:     HOXA10

Top Publications

  1. Satokata I, Benson G, Maas R. Sexually dimorphic sterility phenotypes in Hoxa10-deficient mice. Nature. 1995;374:460-3 pubmed
    ..We have mutated the AbdB gene Hoxa10 in mice...
  2. Daftary G, Troy P, Bagot C, Young S, Taylor H. Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells. Mol Endocrinol. 2002;16:571-9 pubmed
    Estrogen and progesterone regulate HOXA10 expression in the endometrium, where HOXA10 is necessary for implantation. The integrins are also involved in early embryo-endometrial interactions...
  3. Kim J, Taylor H, Akbas G, Foucher I, Trembleau A, Jaffe R, et al. Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells. Biol Reprod. 2003;68:24-30 pubmed
    ..b>HOXA10, a homeobox transcription factor, is important in the decidualization process...
  4. Akbas G, Song J, Taylor H. A HOXA10 estrogen response element (ERE) is differentially regulated by 17 beta-estradiol and diethylstilbestrol (DES). J Mol Biol. 2004;340:1013-23 pubmed
    ..To elucidate the molecular mechanism underlying ligand-specific estrogen regulation of HOXA10 expression, we characterized regulatory regions of the human HOXA10 gene...
  5. Bei L, Huang W, Wang H, Shah C, Horvath E, Eklund E. HoxA10 activates CDX4 transcription and Cdx4 activates HOXA10 transcription in myeloid cells. J Biol Chem. 2011;286:19047-64 pubmed publisher
    b>HoxA10 is a homeodomain transcription factor that influences a number of developmental processes, including hematopoiesis...
  6. Shah C, Bei L, Wang H, Platanias L, Eklund E. HoxA10 protein regulates transcription of gene encoding fibroblast growth factor 2 (FGF2) in myeloid cells. J Biol Chem. 2012;287:18230-48 pubmed publisher
    b>HoxA10 is a member of a highly conserved family of homeodomain transcription factors that are involved in definitive hematopoiesis and implicated in the pathogenesis of acute myeloid leukemia (AML)...
  7. Piltonen T. Polycystic ovary syndrome: Endometrial markers. Best Pract Res Clin Obstet Gynaecol. 2016;37:66-79 pubmed publisher
    ..receptors), ARs (androgen receptors), and steroid receptor coactivators), endometrial receptivity/decidualization (HOXA10, ?v?3 integrin, and IGFBP-1 (insulin-like growth factor-binding protein 1)), glucose metabolism (IRs (insulin ..
  8. Laheri S, Ashary N, Bhatt P, Modi D. Oviductal glycoprotein 1 (OVGP1) is expressed by endometrial epithelium that regulates receptivity and trophoblast adhesion. J Assist Reprod Genet. 2018;35:1419-1429 pubmed publisher
    ..Knockdown of OVGP1 in Ishikawa cells reduced mRNA expression of ITGAV, ITGB3, ITGA5, HOXA10, LIF, and IL15; it increased the expression of HOXA11, MMP9, TIMP1, and TIMP3...
  9. Brinkmeier M, Geister K, Jones M, Waqas M, Maillard I, Camper S. The Histone Methyltransferase Gene Absent, Small, or Homeotic Discs-1 Like Is Required for Normal Hox Gene Expression and Fertility in Mice. Biol Reprod. 2015;93:121 pubmed publisher
    ..Specifically, expression of Hoxa11 and Hoxd10 are altered in the epididymis of Ash1l mutant males and Hoxa10 is reduced in the uterus of Ash1l mutant females...

More Information

Publications205 found, 100 shown here

  1. Karamitros D, Patmanidi A, Kotantaki P, Potocnik A, Bähr Ivacevic T, Benes V, et al. Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors. Development. 2015;142:70-81 pubmed publisher
    ..The chromatin landscape was also modified at the regulatory regions of HOXA10 and GATA1...
  2. Johansen S, Brenner A, Bartaula Brevik S, Reikvam H, Bruserud Ø. The Possible Importance of ?3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia. Int J Mol Sci. 2018;19: pubmed publisher
    ..The ?3 expression seems to be regulated by HomeboxA9 (HoxA9) and HoxA10, and the increased ?3 expression then activates spleen tyrosine kinase (Syk) and thereby contributes to cytokine ..
  3. Li X, Shen C, Liu X, He J, Ding Y, Gao R, et al. Exposure to benzo[a]pyrene impairs decidualization and decidual angiogenesis in mice during early pregnancy. Environ Pollut. 2017;222:523-531 pubmed publisher
    ..The expression of several decidualization-related factors, including FOXO1, HoxA10, and BMP2, were altered after BaP treatment...
  4. Jang H, Myoung S, Choe J, Kim T, Cheon Y, Kim Y, et al. Effects of Autologous Platelet-Rich Plasma on Regeneration of Damaged Endometrium in Female Rats. Yonsei Med J. 2017;58:1195-1203 pubmed publisher
    ..34±12.33 μm² (p=0.065). Significantly stronger IHC expression of cytokeratin, homeobox A10 (HOXA10), vascular endothelial growth factor (VEGF), and Ki-67 was found in the PRP-treated group, compared to the ethanol ..
  5. Guo S, Li Z, Yan L, Sun Y, Feng Y. GnRH agonist improves pregnancy outcome in mice with induced adenomyosis by restoring endometrial receptivity. Drug Des Devel Ther. 2018;12:1621-1631 pubmed publisher
    ..35 versus 8 ± 0.56; P = 0.04). The uterine expression levels of Hoxa10, Hoxa11, Lif and integrin b3 mRNA and protein were decreased in the adenomyosis group, and were significantly ..
  6. Parker H, Pushel I, Krumlauf R. Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest. Dev Biol. 2018;444 Suppl 1:S67-S78 pubmed publisher
    ..We highlight early roles for Hox1 genes in cNCC specification, proposing that this may be achieved, in part, by regulation of the balance between ..
  7. Singh S, Rajput Y, Barui A, Sharma R, Datta T. Fat accumulation in differentiated brown adipocytes is linked with expression of Hox genes. Gene Expr Patterns. 2016;20:99-105 pubmed publisher
    ..Irrespective of presence or absence of T3, insulin down regulates HoxA10. T3 results in over expression of HoxA5, HoxC4 and HoxC8 genes, whereas insulin up regulates expression of only ..
  8. Lin Y, Yu J, Wu J, Wang S, Zhang T. Abnormal level of CUL4B-mediated histone H2A ubiquitination causes disruptive HOX gene expression. Epigenetics Chromatin. 2019;12:22 pubmed publisher
    ..Notably, the expression of HOXA10 genes was negatively correlated with CUL4B levels in human anencephaly NTD cases...
  9. Fang F, Munck J, Tang J, Taverna P, Wang Y, Miller D, et al. The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer. Clin Cancer Res. 2014;20:6504-16 pubmed publisher
    ..proposed drivers of ovarian cancer cisplatin resistance (MLH1 and ZIC1), differentiation-associated genes (HOXA10 and HOXA11), and transcription factors (STAT5B)...
  10. Farah O, Biechele S, Rossant J, Dufort D. Porcupine-dependent Wnt activity within the uterine epithelium is essential for fertility. Biol Reprod. 2017;97:688-697 pubmed publisher
    ..dysregulation of receptors and ligands in the Notch signaling pathway (Notch1, Notch4, and Dll4) as well as Hoxa10. Our results demonstrate the crucial requirement of Wnt signaling in the epithelium for fertility and demonstrate ..
  11. Cheng Y, Jutooru I, Chadalapaka G, Corton J, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 2015;6:10840-52 pubmed
    ..cancer cells, HOTTIP does not regulate HOXA13 but plays a role in regulation of several other HOX genes including HOXA10, HOXB2, HOXA11, HOXA9 and HOXA1...
  12. Nakajima T, Iguchi T, Sato T. Retinoic acid signaling determines the fate of uterine stroma in the mouse Müllerian duct. Proc Natl Acad Sci U S A. 2016;113:14354-14359 pubmed
    ..Although RAR did not directly bind to the homeobox A10 (Hoxa10) promoter region, RA-RAR signaling stimulated Hoxa10 expression...
  13. Rekker K, Tasa T, Saare M, Samuel K, Kadastik U, Karro H, et al. Differentially-Expressed miRNAs in Ectopic Stromal Cells Contribute to Endometriosis Development: The Plausible Role of miR-139-5p and miR-375. Int J Mol Sci. 2018;19: pubmed publisher
    ..showed that the overexpression of miR-139-5p resulted in the downregulation of homeobox A9 (HOXA9) and HOXA10 expression, whereas the endothelin 1 (EDN1) gene was regulated by miR-375...
  14. Zhang Y, Zhang L, Yu C, Du X, Liu X, Liu J, et al. Effects of interferon tau on endometrial epithelial cells in caprine in vitro. Gene Expr Patterns. 2017;25-26:142-148 pubmed publisher
    ..Furthermore, regulation of HOXA10, COX-2, PRL, PTEN and STAT3 pathway in caprine EECs was likely to be contributed by IFNT at 1 ng/ml to improve ..
  15. Nakayama S, Satou K, Orito W, Ogasawara M. Ordered expression pattern of Hox and ParaHox genes along the alimentary canal in the ascidian juvenile. Cell Tissue Res. 2016;365:65-75 pubmed publisher
    ..Expression of Hox1 to Hox4 is restricted to the posterior region of pharyngeal derivatives...
  16. Zieger E, Candiani S, Garbarino G, Croce J, Schubert M. Roles of Retinoic Acid Signaling in Shaping the Neuronal Architecture of the Developing Amphioxus Nervous System. Mol Neurobiol. 2018;55:5210-5229 pubmed publisher
    ..of dopamine-containing cells in the ectoderm and of GABA neurons in the neural tube, probably by regulating Hox1 and Hox3 gene expression, respectively...
  17. Kadota M, Hara Y, Tanaka K, Takagi W, Tanegashima C, Nishimura O, et al. CTCF binding landscape in jawless fish with reference to Hox cluster evolution. Sci Rep. 2017;7:4957 pubmed publisher
    ..We analyzed CTCF binding inside Hox clusters, which revealed a reinforcement of CTCF binding in the region spanning Hox1-4 genes that is unique to lamprey...
  18. Yang G, Yin B. Therapeutic effects of long-circulating miR-135a-containing cationic immunoliposomes against gallbladder carcinoma. Sci Rep. 2017;7:5982 pubmed publisher
    ..Additionally, miR-135a targeted and regulated the expression of ROCK1, HOXA10 and BCL-2...
  19. Sugimura R, Jha D, Han A, Soria Valles C, da Rocha E, Lu Y, et al. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017;545:432-438 pubmed publisher
    ..We recover seven transcription factors (ERG, HOXA5, HOXA9, HOXA10, LCOR, RUNX1 and SPI1) that are sufficient to convert haemogenic endothelium into haematopoietic stem and ..
  20. Wei Y, Yan Z, Wu C, Zhang Q, Zhu Y, Li K, et al. Integrated analysis of dosage effect lncRNAs in lung adenocarcinoma based on comprehensive network. Oncotarget. 2017;8:71430-71446 pubmed publisher
    ..Third, competing endogenous RNA network analysis inferred that lncRNA ENSG00000240990 competed with HOXA10 to absorb hsa-let-7a/b/f/g-5p and affected patient prognosis in LUAD...
  21. Painter J, Anderson C, Nyholt D, Macgregor S, Lin J, Lee S, et al. Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis. Nat Genet. 2011;43:51-4 pubmed publisher
    ..20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10.
  22. Zhou Y, Wang J, Wang L, Xiao S, Wang X, Yan H, et al. Effect of beta-cypermethrin exposure on embryo implantation in mice. Reprod Toxicol. 2018;76:1-11 pubmed publisher
    ..05), E2 level in the serum, and the expression of Homeobox A10 (HoxA10) protein. In addition, β-CP significantly increased ERa and PRA protein expression levels...
  23. Sasakura Y. The Enhancer Trap in Ciona. Adv Exp Med Biol. 2018;1029:121-129 pubmed publisher
    ..the presence of enhancers sensitive to the orientation of the gene that they regulate, and the functions of the Hox1 gene have been revealed...
  24. Chen L, Wang B, Wang S, Yang J, Hu J, Xie Z, et al. OPMSP: A Computational Method Integrating Protein Interaction and Sequence Information for the Identification of Novel Putative Oncogenes. Protein Pept Lett. 2016;23:1081-1094 pubmed
    ..Six of these genes-ESR1, CDK9, SEPT2, HOXA10, LMX1B, and NR2C2-are extensively discussed. Several lines of evidence indicate that they may be novel oncogenes.
  25. Wei Q, St Clair J, Fu T, Stratton P, Nieman L. Reduced expression of biomarkers associated with the implantation window in women with endometriosis. Fertil Steril. 2009;91:1686-91 pubmed publisher
    ..of biomarkers of implantation, glycodelin A (GdA), osteopontin (OPN), lysophosphatidic acid receptor 3 (LPA3), and HOXA10, in eutopic endometrium of women with and without endometriosis. Prospective observational study...
  26. Milesi M, Alarcón R, Ramos J, Muñoz de Toro M, Luque E, Varayoud J. Neonatal exposure to low doses of endosulfan induces implantation failure and disrupts uterine functional differentiation at the pre-implantation period in rats. Mol Cell Endocrinol. 2015;401:248-59 pubmed publisher
    ..E2) and progesterone (P); the endometrial proliferation decreased, which was associated with silencing of Hoxa10 in the Endo600-treated rats...
  27. Nagy I, Kovács K, Rákhely G, Maróti G. HupO, a Novel Regulator Involved in Thiosulfate-Responsive Control of HupSL [NiFe]-Hydrogenase Synthesis in Thiocapsa roseopersicina. Appl Environ Microbiol. 2016;82:2039-2049 pubmed publisher
    ..purple sulfur bacterium Thiocapsa roseopersicina harbors four functional [NiFe]-hydrogenases: HynSL, HupSL, Hox1, and Hox2...
  28. Uehiro N, Sato F, Pu F, Tanaka S, Kawashima M, Kawaguchi K, et al. Circulating cell-free DNA-based epigenetic assay can detect early breast cancer. Breast Cancer Res. 2016;18:129 pubmed
    ..The methylation array analysis identified 12 novel epigenetic markers (JAK3, RASGRF1, CPXM1, SHF, DNM3, CAV2, HOXA10, B3GNT5, ST3GAL6, DACH1, P2RX3, and chr8:23572595) for detecting BC...
  29. Godfrey T, Wildman B, Beloti M, Kemper A, Ferraz E, Roy B, et al. The microRNA-23a cluster regulates the developmental HoxA cluster function during osteoblast differentiation. J Biol Chem. 2018;293:17646-17660 pubmed publisher
    ..the miR-23a cluster in preosteoblasts decreased and increased, respectively, the expression of the proteins HOXA5, HOXA10, and HOXA11; these proteins' mRNAs exhibited significant binding with the miR-23a cluster miRNAs, and miRNA 3'-UTR ..
  30. Zhu Y, Luo M, Huang H, Du X, Chen D, Xing Q, et al. HOXA10, EMX2 and TENM1 expression in the mid-secretory endometrium of infertile women with a Müllerian duct anomaly. Reprod Biomed Online. 2016;32:388-93 pubmed publisher
    Homeobox A10 (HOXA10) and empty spiracles homeobox 2 (EMX2) are two transcription factors necessary for female Müllerian duct differentiation and development...
  31. Andikyan V, Taylor H. WT1 represses HOX gene expression in the regulation of gynaecologic tumour histologic type. J Cell Mol Med. 2009;13:4522-31 pubmed publisher
    ..These genes also direct differential Mullerian transformation of the ovarian cancer cells. The homeobox gene HOXA10 controls uterine organogenesis during embryonic development and similarly is expressed in endometroid epithelial ..
  32. Shen Z, Zhao K, Du T. HOXA10 promotes nasopharyngeal carcinoma cell proliferation and invasion via inducing the expression of ZIC2. Eur Rev Med Pharmacol Sci. 2017;21:945-952 pubmed
    ..to explore the dysregulated genes in nasopharyngeal carcinoma (NPC) and to investigate the regulative effect of HOXA10 on ZIC2 expression and their involvement in NPC cell proliferation and invasion...
  33. Parasar P, Sacha C, Ng N, McGuirk E, Chinthala S, Ozcan P, et al. Differentiating mouse embryonic stem cells express markers of human endometrium. Reprod Biol Endocrinol. 2017;15:52 pubmed publisher
    ..Finally, quantitative PCR demonstrated significantly amplified expression of transcription factors Hoxa10 and Foxa2 in CD13+ EBs isolated by FACS (p = 0.03)...
  34. Yang Q, Zhang Q, Zhang X, You L, Wang W, Liu W, et al. HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism. J Virol. 2019;93: pubmed publisher
    ..This study reveals a distinct mechanism underlying the regulation of HBV replication. HBV activates homeobox A10 (HoxA10) in human hepatocytes, leukocytes, peripheral blood mononuclear cells (PBMCs), HepG2-NTCP cells, leukocytes ..
  35. Ma W, Li Y, Wang M, Li H, Su T, Li Y, et al. Associations of Polymorphisms in WNT9B and PBX1 with Mayer-Rokitansky-Küster-Hauser Syndrome in Chinese Han. PLoS ONE. 2015;10:e0130202 pubmed publisher
    ..Seventeen candidate loci in the AMH, PBX1, WNT4, WNT7A, WNT9B, HOXA10, HOXA11, LHXA1 and GALT genes were genotyped using the Sequenom MassARRAY iPLEX platform...
  36. Signorile P, Severino A, Santoro M, Spyrou M, Viceconte R, Baldi A. Methylation analysis of HOXA10 regulatory elements in patients with endometriosis. BMC Res Notes. 2018;11:722 pubmed publisher
    ..In this study, we have evaluated the methylation status of HOXA10 gene regulation regions in a cohort of 22 endometriosis patients respect to a control group of 6 healthy women...
  37. Nagel S, Venturini L, Meyer C, Kaufmann M, Scherr M, Drexler H, et al. Transcriptional deregulation of oncogenic myocyte enhancer factor 2C in T-cell acute lymphoblastic leukemia. Leuk Lymphoma. 2011;52:290-7 pubmed publisher
    ..thus identifying potential regulatory binding sites for GFI1B, basic helix-loop-helix proteins, STAT5, and HOXA9/HOXA10. Chromatin immunoprecipitation and overexpression analyses demonstrated direct activation by GFI1B and LYL1 and ..
  38. Yang B, Li S, Ma L, Liu H, Liu J, Shao J. Expression and mechanism of action of miR-196a in epithelial ovarian cancer. Asian Pac J Trop Med. 2016;9:1105-1110 pubmed publisher
    ..and invasion abilities of ovarian carcinoma cells and Western blot was employed to detect the expression of HOXA10 protein...
  39. Taylor H, Vanden Heuvel G, Igarashi P. A conserved Hox axis in the mouse and human female reproductive system: late establishment and persistent adult expression of the Hoxa cluster genes. Biol Reprod. 1997;57:1338-45 pubmed
    ..The late establishment of a Hox axis and persistent expression of Hox genes in the adult may play an important role in preserving this plasticity...
  40. Kay S, Madan T. Fertility defects in Surfactant associated protein D knockout female mice: altered ovarian hormone profile. Mol Immunol. 2016;71:87-97 pubmed publisher
    ..We also demonstrate altered expression of ovarian hormone receptors and hormone responsive genes ITGB1, LIF and HOXA10 in uteri of these mice...
  41. Lawrence H, Sauvageau G, Ahmadi N, Lopez A, LeBeau M, Link M, et al. Stage- and lineage-specific expression of the HOXA10 homeobox gene in normal and leukemic hematopoietic cells. Exp Hematol. 1995;23:1160-6 pubmed
    ..We have previously demonstrated that the HOXA10 gene is expressed in unfractionated normal marrow and in immortalized leukemic cell lines with myelomonocytic ..
  42. Shen W, Krishnan K, Lawrence H, Largman C. The HOX homeodomain proteins block CBP histone acetyltransferase activity. Mol Cell Biol. 2001;21:7509-22 pubmed
  43. Liu X, Zhu G, Zhong G. Regulatory effect of estrogen, progestin and HB-EGF on the expression of HOXA10 gene in Ishikawa cells. J Huazhong Univ Sci Technolog Med Sci. 2007;27:464-7 pubmed
    b>HOXA10 gene plays an essential role in differentiation of the endometrium and in human reproduction. The aim of this study was to investigate the regulatory effect of sex steroids and HB-EGF on HOXA10 gene in Ishikawa cells...
  44. Zanatta A, Rocha A, Carvalho F, Pereira R, Taylor H, Motta E, et al. The role of the Hoxa10/HOXA10 gene in the etiology of endometriosis and its related infertility: a review. J Assist Reprod Genet. 2010;27:701-10 pubmed publisher
    ..this review is focused on the most recent clinical and laboratory findings regarding the association of HOXA10 with endometriosis and infertility...
  45. Libório Kimura T, Jung H, Chan E. miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer. Oral Oncol. 2015;51:151-7 pubmed publisher
    ..Quantitative miRNA analyses were performed on oral tumor RNA and oral cancer cell lines. HOXA10 was selected for further analysis based on bioinformatics analysis of miR-494 targets and a previous report of ..
  46. Li D, Guo C, Yue L, Duan C, Yang Z, Cao H, et al. Expression, regulation and function of Hmgn3 during decidualization in mice. Mol Cell Endocrinol. 2015;413:13-25 pubmed publisher
    ..Hmgn3 could mediate the effects of Hoxa10 and cAMP on the expression of Prl8a2 and Prl3c1...
  47. Bourdiec A, Ahmad S, Lachhab A, Akoum A. Regulation of inflammatory and angiogenesis mediators in a functional model of decidualized endometrial stromal cells. Reprod Biomed Online. 2016;32:85-95 pubmed publisher
    ..Additionally, endometrial cells showed increased expression of homeobox HOXA10 and HOXA11 and LIFR, which are known to be involved in endometrial embryo receptivity...
  48. Tapia Pizarro A, Archiles S, Argandoña F, Valencia C, Zavaleta K, Cecilia Johnson M, et al. hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells. Mol Hum Reprod. 2017;23:393-405 pubmed publisher
    ..mRNA levels for secreted frizzled-related protein 4 (SFRP4) at 24 h, whereas it increased those for homeobox A10 (HOXA10) at 48 h (P = 0.041 and P = 0.022 versus control, respectively)...
  49. Wu Y, Halverson G, Basir Z, Strawn E, Yan P, Guo S. Aberrant methylation at HOXA10 may be responsible for its aberrant expression in the endometrium of patients with endometriosis. Am J Obstet Gynecol. 2005;193:371-80 pubmed
    b>HOXA10, expressed in endometrium, plays an important role in uterine receptivity at the time of implantation. In the endometrium of women with endometriosis, its expression is reduced...
  50. Szczepanska M, Wirstlein P, Luczak M, Jagodziński P, Skrzypczak J. Reduced expression of HOXA10 in the midluteal endometrium from infertile women with minimal endometriosis. Biomed Pharmacother. 2010;64:697-705 pubmed publisher
    Recent human and animal studies have suggested that reduced HOXA10 expression in the implantation window of eutopic endometrium may contribute to infertility in women with endometriosis...
  51. Cermik D, Karaca M, Taylor H. HOXA10 expression is repressed by progesterone in the myometrium: differential tissue-specific regulation of HOX gene expression in the reproductive tract. J Clin Endocrinol Metab. 2001;86:3387-92 pubmed
    ..We have previously shown that HOXA10 is expressed in the developing uterus and later in the adult human endometrium...
  52. Choi C, Chung Y, Slape C, Aplan P. A NUP98-HOXD13 fusion gene impairs differentiation of B and T lymphocytes and leads to expansion of thymocytes with partial TCRB gene rearrangement. J Immunol. 2009;183:6227-35 pubmed publisher
    ..Thymi from NHD13 mice were smaller and overexpressed Hoxa cluster genes, including Hoxa7, Hoxa9, and Hoxa10. In addition, the NHD13 thymi contained fewer thymocytes, with an increased percentage of CD4(-)/CD8(-) (double-..
  53. Lin J, Zong L, Kennedy S, Zondervan K. Coding regions of INHBA, SFRP4 and HOXA10 are not implicated in familial endometriosis linked to chromosome 7p13-15. Mol Hum Reprod. 2011;17:605-11 pubmed publisher
    ..regions of three candidate genes with a known role in endometrial development and function-INHBA, SFRP4 and HOXA10-located under or very near the linkage peak, for potential causal mutations using Sanger sequencing...
  54. Zhang H, Li J, Li G, Wang S. Activation of ARK5/miR-1181/HOXA10 axis promotes epithelial-mesenchymal transition in ovarian cancer. Oncol Rep. 2015;34:1193-202 pubmed publisher
    ..Downstream target genes of miR-1181 were searched, and it was identified that miR-1181 degraded HOXA10 by targeting its 3' untranslated region (3'UTR) in ovarian cancer cells...
  55. B Shcherban A, A Salina E. Dataset of the HOX1 gene sequences of the wheat polyploids and their diploid relatives. Data Brief. 2018;16:147-153 pubmed publisher
    ..The sequencing data used here is available at DDBJ/EMBL/GenBank under the accession numbers MG000630-MG000698...
  56. Liang Q, Sun H, Wu X, Ou X, Gao G, Jin Y, et al. Development of New mRNA Markers for the Identification of Menstrual Blood. Ann Clin Lab Sci. 2018;48:55-62 pubmed
    The aim of this study was to screen 3 mRNA markers (i.e., PAEP, LAPR3, and HOXA10) with diverse expression in different body fluids and to develop a method for the identification of menstrual blood using these mRNA markers. Body fluid (i...
  57. Buske C, Feuring Buske M, Antonchuk J, Rosten P, Hogge D, Eaves C, et al. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Blood. 2001;97:2286-92 pubmed
    ..imbalanced expression of these transcription factors, in particular of the Abd-like A cluster HOX genes HOXA9 and HOXA10, to leukemogenesis...
  58. DU H, Sarno J, Taylor H. HOXA10 inhibits Kruppel-like factor 9 expression in the human endometrial epithelium. Biol Reprod. 2010;83:205-11 pubmed publisher
    ..b>HOXA10 partially mediates progesterone responsiveness in the endometrium...
  59. Gao F, Bian F, Ma X, Kalinichenko V, Das S. Control of regional decidualization in implantation: Role of FoxM1 downstream of Hoxa10 and cyclin D3. Sci Rep. 2015;5:13863 pubmed publisher
    ..We further showed that Hoxa10 and cyclin D3, two decidual markers, control transcriptional regulation and intra-nuclear protein translocation of ..
  60. Troy P, Daftary G, Bagot C, Taylor H. Transcriptional repression of peri-implantation EMX2 expression in mammalian reproduction by HOXA10. Mol Cell Biol. 2003;23:1-13 pubmed
    b>HOXA10 is necessary for mammalian reproduction; however, its transcriptional targets are not completely defined. EMX2, a divergent homeobox gene, is necessary for urogenital tract development...
  61. Eun Kwon H, Taylor H. The role of HOX genes in human implantation. Ann N Y Acad Sci. 2004;1034:1-18 pubmed
    ..b>HOXA10 and HOXA11 expression increases during the menstrual cycle, increasing drastically in the midluteal phase, at the ..
  62. Modi D, Godbole G. HOXA10 signals on the highway through pregnancy. J Reprod Immunol. 2009;83:72-8 pubmed publisher
    ..In recent years HomeoboxA10 (HOXA10) has emerged as one of the most promising candidates which regulate the events occurring in the maternal ..
  63. Huang J, Meng Y, Liu Y, Chen Y, Yang H, Chen D, et al. MicroRNA-320a Regulates the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells by Targeting HOXA10. Cell Physiol Biochem. 2016;38:40-8 pubmed publisher
    ..The bone morphogenetic protein-inducible gene homeobox a10 (HOXA10) is a critical regulator of osteogenesis...
  64. Kulp J, Mamillapalli R, Taylor H. Aberrant HOXA10 Methylation in Patients With Common Gynecologic Disorders: Implications for Reproductive Outcomes. Reprod Sci. 2016;23:455-63 pubmed publisher
    HomeoboxA10 (HOXA10) is a transcription factor that is crucial for the development and patterning of the uterus during embryogenesis. In the adult endometrium, HOXA10 expression is regulated by steroid hormones and embryonic signals...
  65. Taghon T, Stolz F, De Smedt M, Cnockaert M, Verhasselt B, Plum J, et al. HOX-A10 regulates hematopoietic lineage commitment: evidence for a monocyte-specific transcription factor. Blood. 2002;99:1197-204 pubmed
    ..These data show that HOX-A10 can act as an important key regulator of lineage determination in human hematopoietic progenitor cells. ..
  66. Yoshida H, Broaddus R, Cheng W, Xie S, Naora H. Deregulation of the HOXA10 homeobox gene in endometrial carcinoma: role in epithelial-mesenchymal transition. Cancer Res. 2006;66:889-97 pubmed
    ..The homeobox gene HOXA10 controls uterine organogenesis during embryonic development and functional endometrial differentiation in the ..
  67. Fambrini M, Bussani C, Sorbi F, Pieralli A, Cioni R. Methylation of the HOXA10 homeobox gene promoter is associated with endometrial cancer: a pilot study. J Obstet Gynaecol. 2013;33:519-20 pubmed publisher
    ..We compare the methylation profile of HOXA10 promoter gene in 19 histologically proven endometrioid cancers and 27 normal endometrial tissues...
  68. Jiang R, Ding L, Zhou J, Huang C, Zhang Q, Jiang Y, et al. Enhanced HOXA10 sumoylation inhibits embryo implantation in women with recurrent implantation failure. Cell Death Discov. 2017;3:17057 pubmed publisher
    b>HOXA10 has emerged as an important molecular marker of endometrial receptivity...
  69. Durston A, Zhu K. A time space translation hypothesis for vertebrate axial patterning. Semin Cell Dev Biol. 2015;42:86-93 pubmed publisher
    ..Hox functionality is implicated because knocking out the Hox1 paralogue group not only disrupts expression of Hox1 genes but also of the whole spatially collinear axial Hox ..
  70. Shao L, Chen Z, Peng D, Soutto M, Zhu S, Bates A, et al. Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells. Mol Cancer Res. 2018;16:696-706 pubmed publisher
    ..01). In addition, it was determined that HOXA10, a homeobox family member and host gene for miR-196b-5p, is overexpressed and positively correlated with miR-196b-..
  71. Sheng K, Lu J, Zhao H. ELK1-induced upregulation of lncRNA HOXA10-AS promotes lung adenocarcinoma progression by increasing Wnt/?-catenin signaling. Biochem Biophys Res Commun. 2018;501:612-618 pubmed publisher
    In recent years, increasing number of lncRNAs have been studied in lung adenocarcinoma (LAD). LncRNA HOXA10-AS was found to be upregulated in LAD tissues...
  72. Pilato B, Pinto R, De Summa S, Lambo R, Paradiso A, Tommasi S. HOX gene methylation status analysis in patients with hereditary breast cancer. J Hum Genet. 2013;58:51-3 pubmed publisher
    ..In this report, the methylation of HOXA1, HOXA9, HOXA10, HOXB13, HNF1B, OTX1, TLX1 genes have been analyzed in patients with hereditary breast cancer...
  73. Jäger D, Barth T, Brüderlein S, Scheuerle A, Rinner B, von Witzleben A, et al. HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas. Sci Rep. 2017;7:2032 pubmed publisher
    ..Among these were HOXA7, HOXA9, and HOXA10 known to be important for the development of the anterior-posterior body axis...
  74. Bei L, Shah C, Wang H, Huang W, Roy R, Eklund E. ?-Catenin activates the HOXA10 and CDX4 genes in myeloid progenitor cells. J Biol Chem. 2012;287:39589-601 pubmed publisher
    b>HoxA10 is a homeodomain transcription factor that is involved in maintenance of the myeloid progenitor population and implicated in myeloid leukemogenesis...
  75. Saraswat G, Guha R, Mondal K, Saha P, Banerjee S, Chakraborty P, et al. Molecular cues to the anti-implantation effect of nano-puerarin in rats. Reproduction. 2016;151:693-707 pubmed publisher
    ..stromal cell culture) treatment models, we document that PN enforced inhibition of uterine expression of Hbegf and Hoxa10 and their downstream signalling molecules, Cyclin D3 (CCND3)/CDK4...
  76. Makker A, Goel M, Nigam D, Bhatia V, Mahdi A, Das V, et al. Endometrial Expression of Homeobox Genes and Cell Adhesion Molecules in Infertile Women With Intramural Fibroids During Window of Implantation. Reprod Sci. 2017;24:435-444 pubmed publisher
    This study was designed to examine the expression and cellular distribution of homeobox ( HOX) genes ( HOXA10 and HOXA11) and cell adhesion molecules (E-cadherin, N-cadherin, and ?-catenin) during the window of implantation in infertile ..
  77. Daftary G, Taylor H. Hydrosalpinx fluid diminishes endometrial cell HOXA10 expression. Fertil Steril. 2002;78:577-80 pubmed
    To determine the effect of hydrosalpinx fluid on the expression of HOXA10, an essential regulator of endometrial receptivity.
  78. Reddy P, Unni M, Gungi A, Agarwal P, Galande S. Evolution of Hox-like genes in Cnidaria: Study of Hydra Hox repertoire reveals tailor-made Hox-code for Cnidarians. Mech Dev. 2015;138 Pt 2:87-96 pubmed publisher
    ..Phylogenetic analysis of these genes shows bilaterian counterparts of Hox1, Gsx and Mox...
  79. Suzuki S, Nakashima N, Kageyama M, Yamagata K. A phytoestrogen supplement prevents the altered gene expression associated with pregnancy implantation induced by IL-1? in endometrial epithelial cells. Reprod Biol. 2017;17:259-267 pubmed publisher
    ..AglyMax and AglyMax-Sup significantly (p<0.05) induced gene expression of glycodelin-A, HoxA10, IL-11, LIF, MEG-E8 and TGF?1...
  80. Taghon T, Thys K, De Smedt M, Weerkamp F, Staal F, Plum J, et al. Homeobox gene expression profile in human hematopoietic multipotent stem cells and T-cell progenitors: implications for human T-cell development. Leukemia. 2003;17:1157-63 pubmed
    ..Also HOX-B3 and HOX-C4 were expressed throughout thymocyte development. Overall, these data provide novel evidence for an important role of certain HOX genes in human T-cell development. ..
  81. Gosiengfiao Y, Horvat R, Thompson A. Transcription factors GATA-1 and Fli-1 regulate human HOXA10 expression in megakaryocytic cells. DNA Cell Biol. 2007;26:577-87 pubmed
    b>HOXA10 is a member of the HOX family of regulatory genes that are involved in hematopoiesis...
  82. Carrera M, Bitu C, de Oliveira C, Cervigne N, Graner E, Manninen A, et al. HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma. Int J Clin Exp Pathol. 2015;8:3613-23 pubmed
    ..samples of normal mucosa and squamous cell carcinoma (OSCC) and identified differently expressed genes such as HOXA10. The present study aimed to validate the increased expression of HOXA10 in OSCCs, and to investigate the effects ..
  83. Ester A, Weymouth K, Burt A, Wise C, Scott A, Gurnett C, et al. Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot. Am J Med Genet A. 2009;149A:2745-52 pubmed publisher
    ..These results suggest a biologic model for clubfoot in which perturbation of HOX and apoptotic genes together affect muscle and limb development, which may cause the downstream failure of limb rotation into a plantar grade position. ..
  84. Yao J, Fang L, Yang Z, Huang H, Li Y, Deng J, et al. Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML. Biosci Rep. 2014;34:e00156 pubmed publisher
    b>HOXA10, a homeobox-containing gene involved in definitive haematopoiesis, which implicated in the pathogenesis of AML (acute myeloid leukaemia), has been studied extensively...
  85. Park S, Choi E, Bae M, Choi J, Kim Y. A long-range interactive DNA methylation marker panel for the promoters of HOXA9 and HOXA10 predicts survival in breast cancer patients. Clin Epigenetics. 2017;9:73 pubmed publisher
    ..We identified six methylation markers in HOXA9 and HOXA10 promoter regions and their long-range target genes...
  86. Lynch V, Brayer K, Gellersen B, Wagner G. HoxA-11 and FOXO1A cooperate to regulate decidual prolactin expression: towards inferring the core transcriptional regulators of decidual genes. PLoS ONE. 2009;4:e6845 pubmed publisher
    ..In addition, the functional non-equivalence of HoxA-11 and HoxA-10 with respect to PRL regulation suggests that these transcription factors regulate distinct sets of target genes during decidualization. ..
  87. Gonzalez P, Uhlinger K, Lowe C. The Adult Body Plan of Indirect Developing Hemichordates Develops by Adding a Hox-Patterned Trunk to an Anterior Larval Territory. Curr Biol. 2017;27:87-95 pubmed publisher
    ..The larval ectoderm has an anterior molecular signature, while most of the trunk, defined by the expression of hox1-7, is absent...
  88. Zhang L, Wang D, Yu P. LncRNA H19 regulates the expression of its target gene HOXA10 in endometrial carcinoma through competing with miR-612. Eur Rev Med Pharmacol Sci. 2018;22:4820-4827 pubmed publisher
    ..Transcriptase-Polymerase Chain Reaction (qRT-PCR) was used to detect the expression of lncRNA H19, miR-612, and HOXA10 in endometrial carcinoma, and the relationship between lncRNA H19 and survival time was analyzed...
  89. Matsuzaki S, Canis M, Darcha C, Pouly J, Mage G. HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility. Hum Reprod. 2009;24:3180-7 pubmed publisher
    ..One of the underlying causes of infertility in patients with only superficial endometriosis may be altered expression of HOXA-10 in endometrial stromal cells. ..
  90. Zhong G, Wang Y, Liu X. Expression of HOXA10 in endometrial hyperplasia and adenocarcinoma and regulation by sex hormones in vitro. Int J Gynecol Cancer. 2011;21:800-5 pubmed publisher
    The objective of the study was to determine the expression of HOXA10 in human endometrial tissue in endometrial hyperplasia and carcinomas, and regulation by sex steroids in Ishikawa cells...
  91. Wang H, Bei L, Shah C, Hu L, Eklund E. HoxA10 Terminates Emergency Granulopoiesis by Increasing Expression of Triad1. J Immunol. 2015;194:5375-87 pubmed publisher
    Expression of the E3 ubiquitin ligase Triad1 is greater in mature granulocytes than in myeloid progenitor cells. HoxA10 actives transcription of the gene encoding Triad1 (ARIH2) during myeloid differentiation, but the contribution of ..
  92. Fantini S, Salsi V, Vitobello A, Rijli F, Zappavigna V. MicroRNA-196b is transcribed from an autonomous promoter and is directly regulated by Cdx2 and by posterior Hox proteins during embryogenesis. Biochim Biophys Acta. 2015;1849:1066-80 pubmed publisher
    ..transcript, which starts within an autonomous TATA box promoter and is not in physical continuity with either the Hoxa10 or Hoxa9 main primary transcripts...