HOXA1

Summary

Gene Symbol: HOXA1
Description: homeobox A1
Alias: BSAS, HOX1, HOX1F, homeobox protein Hox-A1, HOX A1 homeodomain protein, Hox 1.6-like protein, homeo box A1, homeobox 1F, homeobox protein Hox-1F, lab-like protein
Species: human
Products:     HOXA1

Top Publications

  1. Ingram J, Stodgell C, Hyman S, Figlewicz D, Weitkamp L, Rodier P. Discovery of allelic variants of HOXA1 and HOXB1: genetic susceptibility to autism spectrum disorders. Teratology. 2000;62:393-405 pubmed
    ..Mice with null mutations of Hoxa1 or Hoxb1, two genes critical to hindbrain development, have phenotypic features frequently observed in autism, but ..
  2. Li J, Tabor H, Nguyen L, Gleason C, Lotspeich L, Spiker D, et al. Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families. Am J Med Genet. 2002;114:24-30 pubmed
    A recent report suggested that the HoxA1 and/or HoxB1 genes play a role in susceptibility to autism...
  3. Devlin B, Bennett P, Cook E, Dawson G, Gonen D, Grigorenko E, et al. No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network. Am J Med Genet. 2002;114:667-72 pubmed
    A recent study by Ingram et al. [2000b: Teratology 62:393-405] suggests a (His)73(Arg) polymorphism (A:G) in HOXA1 contributes substantially to a liability for autism...
  4. Zhang X, Zhu T, Chen Y, Mertani H, Lee K, Lobie P. Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene. J Biol Chem. 2003;278:7580-90 pubmed
    ..carcinoma cells increased the expression and transcriptional activity of the homeobox domain containing protein HOXA1. Forced expression of HOXA1 in human mammary carcinoma cells resulted in increased total cell number primarily by ..
  5. Conciatori M, Stodgell C, Hyman S, O Bara M, Militerni R, Bravaccio C, et al. Association between the HOXA1 A218G polymorphism and increased head circumference in patients with autism. Biol Psychiatry. 2004;55:413-9 pubmed
    The HOXA1 gene plays a major role in brainstem and cranial morphogenesis. The G allele of the HOXA1 A218G polymorphism has been previously found associated with autism...
  6. Sen B, Sinha S, Ahmed S, Ghosh S, Gangopadhyay P, Usha R. Lack of association of HOXA1 and HOXB1 variants with autism in the Indian population. Psychiatr Genet. 2007;17:1 pubmed
  7. Muscarella L, Guarnieri V, Sacco R, Militerni R, Bravaccio C, Trillo S, et al. HOXA1 gene variants influence head growth rates in humans. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:388-90 pubmed
    We previously described a significant association between the HOXA1 G218 allele and increased head circumference in autism [Conciatori et al. (2004); Biol Psychiatry 55:413-419]...
  8. Mohankumar K, Perry J, Kannan N, Kohno K, Gluckman P, Emerald B, et al. Transcriptional activation of signal transducer and activator of transcription (STAT) 3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell. Endocrinology. 2008;149:2219-29 pubmed publisher
    ..However, inhibition of MAPK kinase 1 does not completely prevent HOXA1-stimulated oncogenic transformation, suggesting the involvement of additional signal transduction pathways...
  9. Muscarella L, Guarnieri V, Sacco R, Curatolo P, Manzi B, Alessandrelli R, et al. Candidate gene study of HOXB1 in autism spectrum disorder. Mol Autism. 2010;1:9 pubmed publisher
    ..a major role in brainstem morphogenesis and could partly determine the cranial circumference in conjunction with HOXA1. In our sample, HOXA1 alleles significantly influence head growth rates both in autistic patients and in ..

More Information

Publications141 found, 100 shown here

  1. Ohuchida K, Mizumoto K, Lin C, Yamaguchi H, Ohtsuka T, Sato N, et al. MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene. Ann Surg Oncol. 2012;19:2394-402 pubmed publisher
    ..01), but had no effect on their proliferation. Inhibition of HOXA1, a target of miR-10a, promoted the invasiveness of pancreatic cancer cells (P<.01)...
  2. Bitu C, Destro M, Carrera M, da Silva S, Graner E, Kowalski L, et al. HOXA1 is overexpressed in oral squamous cell carcinomas and its expression is correlated with poor prognosis. BMC Cancer. 2012;12:146 pubmed publisher
    ..The effects of HOXA1 on proliferation, apoptosis, adhesion, invasion, epithelial-mesenchymal transition (EMT) and anchorage-independent ..
  3. Zha T, Hu B, Yu H, Tan Y, Zhang Y, Zhang K. Overexpression of HOXA1 correlates with poor prognosis in patients with hepatocellular carcinoma. Tumour Biol. 2012;33:2125-34 pubmed publisher
    b>HOXA1 overexpression is sufficient for malignant transformation of nontumorigenic epithelial cells. It is known that HOXA1, which was upregulated in squamous cell carcinomas, affects both cell growth and death...
  4. Studer M, Gavalas A, Marshall H, Ariza McNaughton L, Rijli F, Chambon P, et al. Genetic interactions between Hoxa1 and Hoxb1 reveal new roles in regulation of early hindbrain patterning. Development. 1998;125:1025-36 pubmed
    In the developing vertebrate hindbrain Hoxa1 and Hoxb1 play important roles in patterning segmental units (rhombomeres)...
  5. Collins J, Schroer R, Bird J, Michaelis R. The HOXA1 A218G polymorphism and autism: lack of association in white and black patients from the South Carolina Autism Project. J Autism Dev Disord. 2003;33:343-8 pubmed
    A recent study has suggested that the A218G polymorphism in the homeobox A1 (HOXA1) gene may influence susceptibility to autism...
  6. Zhu T, Starling Emerald B, Zhang X, Lee K, Gluckman P, Mertani H, et al. Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res. 2005;65:317-24 pubmed
    ..Forced expression of a single orthotopically expressed wild-type gene is therefore sufficient for oncogenic transformation of the immortalized human mammary epithelial cell. ..
  7. Zhang X, Emerald B, Mukhina S, Mohankumar K, Kraemer A, Yap A, et al. HOXA1 is required for E-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells. J Biol Chem. 2006;281:6471-81 pubmed
    Forced expression of HOXA1 is sufficient to stimulate oncogenic transformation of immortalized human mammary epithelial cells and subsequent tumor formation...
  8. Mohankumar K, Xu X, Zhu T, Kannan N, Miller L, Liu E, et al. HOXA1-stimulated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells. Oncogene. 2007;26:3998-4008 pubmed
    Expression of homeobox A1 (HOXA1) results in oncogenic transformation of immortalized human mammary epithelial cells with aggressive tumor formation in vivo...
  9. Cheng Y, Jutooru I, Chadalapaka G, Corton J, Safe S. The long non-coding RNA HOTTIP enhances pancreatic cancer cell proliferation, survival and migration. Oncotarget. 2015;6:10840-52 pubmed
    ..HOXA13 but plays a role in regulation of several other HOX genes including HOXA10, HOXB2, HOXA11, HOXA9 and HOXA1. Although HOTTIP and the HOX-associated lncRNA HOTAIR have similar pro-oncogenic functions, they regulate ..
  10. Bell D, Raza S, Bell A, Fuller G, DeMonte F. Whole-transcriptome analysis of chordoma of the skull base. Virchows Arch. 2016;469:439-49 pubmed publisher
    ..The highly expressed developmental genes T, LMX1A, ZIC4, LHX4, and HOXA1 may be potential drivers of this disease.
  11. Sasakura Y. The Enhancer Trap in Ciona. Adv Exp Med Biol. 2018;1029:121-129 pubmed publisher
    ..the presence of enhancers sensitive to the orientation of the gene that they regulate, and the functions of the Hox1 gene have been revealed...
  12. Xiao F, Bai Y, Chen Z, Li Y, Luo L, Huang J, et al. Downregulation of HOXA1 gene affects small cell lung cancer cell survival and chemoresistance under the regulation of miR-100. Eur J Cancer. 2014;50:1541-54 pubmed publisher
    ..The aim of our study is to characterise the clinical significance and functional roles of HOXA1 in SCLC...
  13. Ge S, Son E, Yao R. iDEP: an integrated web application for differential expression and pathway analysis of RNA-Seq data. BMC Bioinformatics. 2018;19:534 pubmed publisher
    ..As an example, we analyzed an RNA-Seq dataset of lung fibroblasts with Hoxa1 knockdown and revealed the possible roles of SP1 and E2F1 and their target genes, including microRNAs, in blocking ..
  14. Mazzoni E, Mahony S, Peljto M, Patel T, Thornton S, McCuine S, et al. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nat Neurosci. 2013;16:1191-1198 pubmed publisher
    ..neural progenitors with retinoic acid leads to activation and binding of retinoic acid receptors (RARs) to the Hox1-Hox5 chromatin domains, which is followed by a rapid domain-wide removal of H3K27me3 and acquisition of cervical ..
  15. Wang X, Yu T, Yan Q, Wang W, Meng N, Li X, et al. AGEs Promote Oxidative Stress and Induce Apoptosis in Retinal Pigmented Epithelium Cells RAGE-dependently. J Mol Neurosci. 2015;56:449-60 pubmed publisher
    ..In conclusion, the present study recognized the apoptosis induction by AGE-BSAs in the retinal epithelium ARPE-19 cells, RAGE-dependently...
  16. Steger J, Füller E, Garcia Cuellar M, Hetzner K, Slany R. Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation. Leukemia. 2015;29:901-8 pubmed publisher
    HOX homeobox proteins are key oncogenic drivers in hematopoietic malignancies. Here we demonstrate that HOXA1, HOXA6 and predominantly HOXA9 are able to induce the production of insulin-like growth factor 1 (Igf1)...
  17. Iglesias A, Bellomo C, Martínez V. [Hantavirus pulmonary syndrome in Buenos Aires, 2009-2014]. Medicina (B Aires). 2016;76:1-9 pubmed
    ..6%, with a maximum value of 45.5% in 2011. Genotype analysis was performed in 30.7% of confirmed cases, AND-BsAs show the highest incidence, it was characterized in 72% of the studied cases...
  18. Li Q, Dong C, Cui J, Wang Y, Hong X. Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme. J Exp Clin Cancer Res. 2018;37:265 pubmed publisher
    ..The expressions of HOTAIRM1 and HOXA1 in GBM tissues and cells were determined by qRT-PCR, and the association between HOTAIRM1, HOXA1 transcription and ..
  19. Ma Y, Wu Y, Chen J, Huang K, Ji B, Chen Z, et al. miR-10a-5p Promotes Chondrocyte Apoptosis in Osteoarthritis by Targeting HOXA1. Mol Ther Nucleic Acids. 2018;14:398-409 pubmed publisher
    ..A luciferase activity assay showed that miR-10a-5p targeted the 3' UTR of the homeobox gene HOXA1, inhibiting its expression...
  20. Balatti V, Oghumu S, Bottoni A, Maharry K, Cascione L, Fadda P, et al. MicroRNA Profiling of Salivary Duct Carcinoma Versus Her2/Neu Overexpressing Breast Carcinoma Identify miR-10a as a Putative Breast Related Oncogene. Head Neck Pathol. 2018;: pubmed publisher
    ..Selected miRNAs and HOXA1 gene were validated by RT-PCR...
  21. Gouti M, Briscoe J, Gavalas A. Anterior Hox genes interact with components of the neural crest specification network to induce neural crest fates. Stem Cells. 2011;29:858-70 pubmed publisher
    ..Despite evidence that simultaneous loss of Hoxa1 and Hoxb1 function resulted in NC specification defects, the role of Hox genes in NC specification has remained ..
  22. Yamaguchi Y, Tanaka S, Kumagai M, Fujimoto Y, Terabayashi T, Matsui Y, et al. Sall4 is essential for mouse primordial germ cell specification by suppressing somatic cell program genes. Stem Cells. 2015;33:289-300 pubmed publisher
    ..In Sall4(del/del) PGC progenitors, somatic cell program genes (Hoxa1 and Hoxb1) were derepressed, while activation of the stem cell program was not impaired...
  23. Zhu J, Ma X, Zhang Y, Ni D, Ai Q, Li H, et al. Establishment of a miRNA-mRNA regulatory network in metastatic renal cell carcinoma and screening of potential therapeutic targets. Tumour Biol. 2016;: pubmed
    ..The expression profiles of NEU2, MASP1, MCL1, ARHGAP11A, HOXA1, and CLDN8 were consistent with the results from the mRNA gene-chip analysis...
  24. Abu Amero K, Kondkar A, Alorainy I, Khan A, Al Enazy L, Oystreck D, et al. Xq26.3 microdeletion in a male with Wildervanck Syndrome. Ophthalmic Genet. 2014;35:18-24 pubmed publisher
    ..The patient had no mutation found by Sanger sequencing of HOXA1, KIF21A, SALL4, and CHN1. He had a 3kB deletion in the X-chromosome at Xq26...
  25. Roux M, Laforest B, Eudes N, Bertrand N, Stefanovic S, Zaffran S. Hoxa1 and Hoxb1 are required for pharyngeal arch artery development. Mech Dev. 2017;143:1-8 pubmed publisher
    ..Previous studies have revealed an overlapping function of Hoxa1 and Hoxb1 during specification of the rhombomeres from which neural crest cells emerge...
  26. Eoh K, Kim H, Lee J, Nam E, Kim S, Kim S, et al. Upregulation of homeobox gene is correlated with poor survival outcomes in cervical cancer. Oncotarget. 2017;8:84396-84402 pubmed publisher
    ..associated with advanced FIGO stage, lymph node metastasis, lymphovascular invasion, and increased HOXA1, HOXA5, HOXA6, and HOXC11 mRNA expression...
  27. Papageorgiou S. Physical Forces May Cause the HoxD Gene Cluster Elongation. Biology (Basel). 2017;6: pubmed publisher
    Hox gene collinearity was discovered be Edward B. Lewis in 1978. It consists of the Hox1, Hox2, Hox3 ordering of the Hox genes in the chromosome from the telomeric to the centromeric side of the chromosome...
  28. Masser D, Stanford D, Freeman W. Targeted DNA methylation analysis by next-generation sequencing. J Vis Exp. 2015;: pubmed publisher
    ..of samples with high quantitative accuracy, we have developed a method called Bisulfite Amplicon Sequencing (BSAS)...
  29. Roux M, Laforest B, Capecchi M, Bertrand N, Zaffran S. Hoxb1 regulates proliferation and differentiation of second heart field progenitors in pharyngeal mesoderm and genetically interacts with Hoxa1 during cardiac outflow tract development. Dev Biol. 2015;406:247-58 pubmed publisher
    ..We have recently shown that Hoxa1 and Hoxb1 are expressed in a sub-population of the SHF contributing to the OFT...
  30. Mirouse A, Barete S, Monfort J, Resche Rigon M, Bouyer A, Comarmond C, et al. Ustekinumab for Behçet's disease. J Autoimmun. 2017;82:41-46 pubmed publisher
    ..25] (p = 0.0005) at week 12. Mean change from baseline to week 12 of Behçet's syndrome activity score (BSAS) was 22.8 ± 0.3 (p = 0.01). The median daily corticosteroids dose decreased from 12.5 (10; 16...
  31. Draime A, Bridoux L, Belpaire M, Pringels T, Tys J, Rezsohazy R. PRDM14, a putative histone methyl-transferase, interacts with and decreases the stability and activity of the HOXA1 transcription factor. Biochim Biophys Acta Gene Regul Mech. 2018;1861:534-542 pubmed publisher
    ..In a recent screen for proteins interacting with HOXA1, we identified a PRDM protein family member, PRDM14, which is known to be transiently co-expressed with HOXA1 in ..
  32. May T, Riker R, Gagnon D, Duarte C, McCrum B, Hoover C, et al. Continuous surface EMG power reflects the metabolic cost of shivering during targeted temperature management after cardiac arrest. Resuscitation. 2018;131:8-13 pubmed publisher
    ..Clinical shivering was monitored hourly using the Bedside Shivering Assessment Scale (BSAS) by bedside nurses who administered intermittent neuromuscular blockade (NMB) when BSAS ≥ 1...
  33. Liu P, Li C, Zhang R, Tang Q, Wei J, Lu Y, et al. An ultrasensitive electrochemical immunosensor for procalcitonin detection based on the gold nanoparticles-enhanced tyramide signal amplification strategy. Biosens Bioelectron. 2019;126:543-550 pubmed publisher
    ..Because a single AuNP is able to load multiple HRPs and BSAs, a number of tyramine labeled biotins (T-B) could be deposited on the proteins adhering to the surface of AuNPs...
  34. Wardwell Ozgo J, Dogruluk T, Gifford A, Zhang Y, Heffernan T, Van Doorn R, et al. HOXA1 drives melanoma tumor growth and metastasis and elicits an invasion gene expression signature that prognosticates clinical outcome. Oncogene. 2014;33:1017-26 pubmed publisher
    ..In this study, we validate and assess the mechanism by which homeobox transcription factor A1 (HOXA1), a pro-invasion oncogene previously identified in a metastasis screen by our group, contributes to melanoma ..
  35. Roux M, Zaffran S. Hox Genes in Cardiovascular Development and Diseases. J Dev Biol. 2016;4: pubmed publisher
    ..In this review, we focus on the emerging role of anteriorly expressed Hox genes (Hoxa1, Hoxb1, and Hoxa3) in cardiac development, specifically their contribution to patterning of ..
  36. He W, Zhang J, Gan T, Xu G, Tang B. Advanced glycation end products induce endothelial-to-mesenchymal transition via downregulating Sirt 1 and upregulating TGF-β in human endothelial cells. Biomed Res Int. 2015;2015:684242 pubmed publisher
    ..Results demonstrated that AGE-BSAs significantly reduced the cluster of differentiation 31 (CD 31) expression, whereas they promoted the expression of ..
  37. Chang H, Shin B, Kim A, Kim H, Kim B. DNA methylation analysis for the diagnosis of thyroid nodules - a pilot study with reference to BRAF(V) (600E) mutation and cytopathology results. Cytopathology. 2016;27:122-30 pubmed publisher
    ..We identified five genes that were significantly hypermethylated in malignant tissues: PTGS2, HOXA1, TMEFF2, p16 and PTEN...
  38. López Romero R, Marrero Rodríguez D, Romero Morelos P, Villegas V, Valdivia A, Arreola H, et al. [The role of developmental HOX genes in cervical cancer]. Rev Med Inst Mex Seguro Soc. 2015;53 Suppl 2:S188-93 pubmed
    ..Studies in CC cell lines, primary tumors and premalignant lesions have suggested the involvement of HOXA1, HOXC5, C6, C8 and C10, HOXD9 and HOXD13 in the process of cervical carcinogenesis...
  39. Ni L, Zhao J, Lu Y, Li W, Li B, Wang X, et al. MicroRNA-30c suppressed giant-cell tumor of bone cell metastasis and growth via targeting HOXA1. Eur Rev Med Pharmacol Sci. 2017;21:4819-4827 pubmed
    ..Dual-luciferase activity assay was recruited to examine the potential target gene HOXA1, which predicted by several databases. Protein level was studied using Western blot...
  40. Csibi S, Demetrovics Z, Szabo A. [Development and psychometric validation of the Brief Smartphone Addiction Scale (BSAS) with schoolchidren]. Psychiatr Hung. 2016;31:71-7 pubmed
    ..001). The Hungarian version of the brief smartphone addiction inventory appears to be a valid and reliable tool for screening for mobile phone addiction among schoolchildren. ..
  41. Shen Y, Jiang Y, Greenlee A, Zhou L, Liu L. MicroRNA expression profiles and miR-10a target in anti-benzo[a] pyrene-7, 8-diol-9, 10-epoxide-transformed human 16HBE cells. Biomed Environ Sci. 2009;22:14-21 pubmed publisher
    ..The expression of a putative target for miR-10a, HOXA1, was analyzed by reverse transcription polymerase chain reaction (RT-PCR) and QRT-PCR...
  42. Sibley C, Yazici Y, Tascilar K, Khan N, Bata Y, Yazici H, et al. Behçet syndrome manifestations and activity in the United States versus Turkey -- a cross-sectional cohort comparison. J Rheumatol. 2014;41:1379-84 pubmed publisher
    ..Disease activity was measured using the Behçet's Syndrome Activity Scale (BSAS) and the Behçet's Disease Current Activity Form (BDCAF) with quality of life measured by the Behçet Disease ..
  43. Fritsch M, Wollesen T, de Oliveira A, Wanninger A. Unexpected co-linearity of Hox gene expression in an aculiferan mollusk. BMC Evol Biol. 2015;15:151 pubmed publisher
    ..In A. crinita the Hox genes Acr-Hox1-5, Hox7 and Post2 are expressed in a co-linear pattern along the antero-posterior axis, but not in molluscan-..
  44. Reddy P, Unni M, Gungi A, Agarwal P, Galande S. Evolution of Hox-like genes in Cnidaria: Study of Hydra Hox repertoire reveals tailor-made Hox-code for Cnidarians. Mech Dev. 2015;138 Pt 2:87-96 pubmed publisher
    ..Phylogenetic analysis of these genes shows bilaterian counterparts of Hox1, Gsx and Mox...
  45. Nakayama S, Satou K, Orito W, Ogasawara M. Ordered expression pattern of Hox and ParaHox genes along the alimentary canal in the ascidian juvenile. Cell Tissue Res. 2016;365:65-75 pubmed publisher
    ..Expression of Hox1 to Hox4 is restricted to the posterior region of pharyngeal derivatives...
  46. Beckman J, Chen C, Nguyen J, Thayanithy V, Subramanian S, Steer C, et al. Regulation of heme oxygenase-1 protein expression by miR-377 in combination with miR-217. J Biol Chem. 2011;286:3194-202 pubmed publisher
    ..In summary, these data suggests that the combination of miR-377 and miR-217 help regulate HO-1 protein expression in the presence of hemin. ..
  47. Zhao S, Niu F, Xu C, Ye L, Bi G, Chen L, et al. Microarray and ChIP-seq data analysis revealed changes in p53-mediated transcriptional regulation in Nutlin-3-treated U2OS cells. Mol Med Rep. 2015;12:4284-4290 pubmed publisher
    ..A total of 39 DEGs were directly regulated by p53 and two were the transcription factors (TFs), E2F2 and HOXA1. E2F2 regulated 25 DEGs, while HOXA1 regulated one DEG...
  48. Wollesen T, Scherholz M, Rodríguez Monje S, Redl E, Todt C, Wanninger A. Brain regionalization genes are co-opted into shell field patterning in Mollusca. Sci Rep. 2017;7:5486 pubmed publisher
    The 'brain regionalization genes' Six3/6, Otx, Pax2/5/8, Gbx, and Hox1 are expressed in a similar fashion in the deuterostome, ecdysozoan, and the cephalopod brain, questioning whether this holds also true for the remaining Mollusca...
  49. Raznahan A, Lee Y, Vaituzis C, Tran L, Mackie S, Tiemeier H, et al. Allelic variation within the putative autism spectrum disorder risk gene homeobox A1 and cerebellar maturation in typically developing children and adolescents. Autism Res. 2012;5:93-100 pubmed publisher
    Homeobox A1 (HOXA1) has been proposed as a candidate gene for autism spectrum disorder (ASD) as it regulates embryological patterning of hind-brain structures implicated in autism neurobiology...
  50. Khan A, Shaheen R, Alkuraya F. The ECEL1-related strabismus phenotype is consistent with congenital cranial dysinnervation disorder. J AAPOS. 2014;18:362-7 pubmed publisher
    ..have been associated with dominant or recessive monogenic mutations in at least 7 different genes (CHN1, SALL4, HOXA1, KIF21A, PHOX2A, TUBB3, ROBO3) that cause phenotypes such as Duane retraction syndrome, congenital fibrosis of the ..
  51. Taminiau A, Draime A, Tys J, Lambert B, Vandeputte J, Nguyen N, et al. HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-?B pathway in a transcription-independent manner. Nucleic Acids Res. 2016;44:7331-49 pubmed publisher
    ..HOX genes have also been linked to oncogenesis and HOXA1 has been described to be active in several cancers, including breast cancer...
  52. Abu Amero K, Khan A, Oystreck D, Kondkar A, Bosley T. The genetics of nonsyndromic bilateral Duane retraction syndrome. J AAPOS. 2016;20:396-400.e2 pubmed publisher
    ..Genes associated with DRS and associated congenital cranial dysinnervation disorders (SALL4, CHN1, HOXA1, TUBB3, and KIF21A) were sequenced in the standard fashion in each patient...
  53. Bosley T, Alorainy I, Salih M, Aldhalaan H, Abu Amero K, Oystreck D, et al. The clinical spectrum of homozygous HOXA1 mutations. Am J Med Genet A. 2008;146A:1235-40 pubmed publisher
    We describe nine previously unreported individuals from six families who have homozygous mutations of HOXA1 and either the Bosley-Salih-Alorainy syndrome (BSAS) or the Athabascan brainstem dysgenesis syndrome (ABDS)...
  54. Dhamija N, Choudhary D, Ladha J, Pillai B, Mitra D. Tat predominantly associates with host promoter elements in HIV-1-infected T-cells - regulatory basis of transcriptional repression of c-Rel. FEBS J. 2015;282:595-610 pubmed publisher
  55. Li A, Marikawa Y. Adverse effect of valproic acid on an in vitro gastrulation model entails activation of retinoic acid signaling. Reprod Toxicol. 2016;66:68-83 pubmed publisher
    ..VPA elevated expression levels of various developmental regulators, including Cdx1 and Hoxa1, known transcriptional targets of retinoic acid (RA) signaling...
  56. Chilton J, Guthrie S. Axons get ahead: Insights into axon guidance and congenital cranial dysinnervation disorders. Dev Neurobiol. 2017;77:861-875 pubmed publisher
    ..The discovery that ocular motility disorders can arise from mutations in transcription factors, including HoxA1, HoxB1, MafB, Phox2A, and Sall4, has revealed gene regulatory networks that pattern the brainstem and/or govern ..
  57. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, et al. miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet. 2014;10:e1004177 pubmed publisher
    ..this miRNA suppresses tumorigenesis, cell movement and invasion in vitro and in vivo through direct targeting of HOXA1, a gene that is both oncogenic and pro-invasive, leading to repression of multiple HOXA1 downstream targets ..
  58. Teo W, Sukumar S. Combining the strength of genomics, nanoparticle technology, and direct intraductal delivery for breast cancer treatment. Breast Cancer Res. 2014;16:306 pubmed publisher
    ..In a recent article, Brock and colleagues reported that overexpressed HOXA1 is a critical event in tumor progression in a mouse mammary tumor model...
  59. Lozić B, Krželj V, Kuzmić Prusac I, Kuzmanić Šamija R, Čapkun V, Lasan R, et al. The OSR1 rs12329305 polymorphism contributes to the development of congenital malformations in cases of stillborn/neonatal death. Med Sci Monit. 2014;20:1531-8 pubmed publisher
    ..The polymorphisms of OSR1 rs12329305, rs9936833 near FOXF1, and HOXA1 rs10951154 were genotyped using the TaqMan allelic discrimination assay...
  60. You L, Zhu L, Yang L, Shi C, Pang L, Zhang J, et al. Transcriptome analysis reveals the potential contribution of long noncoding RNAs to brown adipocyte differentiation. Mol Genet Genomics. 2015;290:1659-71 pubmed publisher
    ..We identified three lncRNAs (Gm15051, Tmem189 and Cebpd) associated with their flanking coding genes (Hoxa1, C/EBPβ and C/EBPδ), which participated in adipose commitment...
  61. Imperio C, McFalls A, Hadad N, Blanco Berdugo L, Masser D, Colechio E, et al. Exposure to environmental enrichment attenuates addiction-like behavior and alters molecular effects of heroin self-administration in rats. Neuropharmacology. 2018;139:26-40 pubmed publisher
    ..Site-specific methylation analysis of EGR1 and EGR2 promoter regions using bisulfite amplicon sequencing (BSAS) revealed hypo-methylation in the EGR2 promoter region and EGR1 intragenic CpG sites with heroin-taking and ..
  62. Ruff J, Saffarini R, Ramoz L, Morrison L, Baker S, Laverty S, et al. Fitness Assays Reveal Incomplete Functional Redundancy of the HoxA1 and HoxB1 Paralogs of Mice. Genetics. 2015;201:727-36 pubmed publisher
    ..we discriminate between these hypotheses by competing mice (Mus musculus) whose Hoxb1 gene has been replaced by Hoxa1, its highly conserved paralog, against matched wild-type controls in seminatural enclosures...
  63. Zou D, Zhou Q, Wang D, Guan L, Yuan L, Li S. The Downregulation of MicroRNA-10b and its Role in Cervical Cancer. Oncol Res. 2016;24:99-108 pubmed publisher
    ..and invasion, and the further mechanism study suggested that its role was possibly through directly targeting HOXA1. These results suggested that the downregulation of miR-10b and the resulting elevated HOXA1 level in cervical ..
  64. Speltini A, Maraschi F, Sturini M, Contini M, Profumo A. Dispersive multi-walled carbon nanotubes extraction of benzenesulfonamides, benzotriazoles, and benzothiazoles from environmental waters followed by microwave desorption and HPLC-HESI-MS/MS. Anal Bioanal Chem. 2017;409:6709-6718 pubmed publisher
    ..analytical method for the simultaneous extraction of environmental emerging contaminants as benzenesulfonamides (BSAs), benzotriazoles (BTRs), and benzothiazoles (BTs) from water samples...
  65. Ciancaglini M, Bellomo C, Torres Cabreros C, Alonso D, Bassi S, Iglesias A, et al. Hantavirus pulmonary syndrome in Tucumán province associated to an unexpected viral genotype. Medicina (B Aires). 2017;77:81-84 pubmed
    ..Remarkably, the viral genotype characterized in this case showed higher nucleotide identity with the Andes-BsAs genotype most prevalent in Buenos Aires province, located 1400 km apart from Tucumán, than with any of the ..
  66. De Kumar B, Parker H, Paulson A, PARRISH M, Pushel I, Singh N, et al. HOXA1 and TALE proteins display cross-regulatory interactions and form a combinatorial binding code on HOXA1 targets. Genome Res. 2017;27:1501-1512 pubmed publisher
    i>Hoxa1 has diverse functional roles in differentiation and development. We identify and characterize properties of regions bound by HOXA1 on a genome-wide basis in differentiating mouse ES cells...
  67. Parker H, Pushel I, Krumlauf R. Coupling the roles of Hox genes to regulatory networks patterning cranial neural crest. Dev Biol. 2018;444 Suppl 1:S67-S78 pubmed publisher
    ..We highlight early roles for Hox1 genes in cNCC specification, proposing that this may be achieved, in part, by regulation of the balance between ..
  68. Wang X, Li Y, Qi W, Zhang N, Sun M, Huo Q, et al. MicroRNA-99a inhibits tumor aggressive phenotypes through regulating HOXA1 in breast cancer cells. Oncotarget. 2015;6:32737-47 pubmed publisher
    ..An integrated bioinformatics analysis identified HOXA1 mRNA as the direct functional target of miR-99a, and this regulation was confirmed by luciferase reporter assay...
  69. Speltini A, Sturini M, Maraschi F, Porta A, Profumo A. Fast low-pressurized microwave-assisted extraction of benzotriazole, benzothiazole and benezenesulfonamide compounds from soil samples. Talanta. 2016;147:322-7 pubmed publisher
    Benzotriazoles (BTRs), benzothiazoles (BTs) and benzenesulfonamides (BSAs), compounds largely used in industrial and household applications, are ubiquitous emerging contaminants...
  70. Nagy I, Kovács K, Rákhely G, Maróti G. HupO, a Novel Regulator Involved in Thiosulfate-Responsive Control of HupSL [NiFe]-Hydrogenase Synthesis in Thiocapsa roseopersicina. Appl Environ Microbiol. 2016;82:2039-2049 pubmed publisher
    ..purple sulfur bacterium Thiocapsa roseopersicina harbors four functional [NiFe]-hydrogenases: HynSL, HupSL, Hox1, and Hox2...
  71. Kadota M, Hara Y, Tanaka K, Takagi W, Tanegashima C, Nishimura O, et al. CTCF binding landscape in jawless fish with reference to Hox cluster evolution. Sci Rep. 2017;7:4957 pubmed publisher
    ..We analyzed CTCF binding inside Hox clusters, which revealed a reinforcement of CTCF binding in the region spanning Hox1-4 genes that is unique to lamprey...
  72. Durston A, Zhu K. A time space translation hypothesis for vertebrate axial patterning. Semin Cell Dev Biol. 2015;42:86-93 pubmed publisher
    ..Hox functionality is implicated because knocking out the Hox1 paralogue group not only disrupts expression of Hox1 genes but also of the whole spatially collinear axial Hox ..
  73. Chen Y, Reese D. Corexit-EC9527A Disrupts Retinol Signaling and Neuronal Differentiation in P19 Embryonal Pluripotent Cells. PLoS ONE. 2016;11:e0163724 pubmed publisher
    ..At non-cytotoxic doses, Corexit-EC9527A inhibited retinol-induced expression of the Hoxa1 gene, which encodes a transcription factor for the regulation of body patterning in the embryo...
  74. Alibaz Oner F, Aldag B, Aldag M, Unal A, Mutiş A, Toptas T, et al. Post-thrombotic syndrome and venous disease-specific quality of life in patients with vascular Behçet's disease. J Vasc Surg Venous Lymphat Disord. 2016;4:301-6 pubmed publisher
    ..The Behçet Syndrome Activity Score (BSAS) questionnaire was used to assess disease activity...
  75. Sussarellu R, Lebreton M, Rouxel J, Akcha F, Rivière G. Copper induces expression and methylation changes of early development genes in Crassostrea gigas embryos. Aquat Toxicol. 2018;196:70-78 pubmed publisher
    ..a stage-dependent expression pattern, which was impaired for some homeobox and DNA methylation genes (Notochord, HOXA1, HOX2, Lox5, DNMT3b and CXXC-1) after copper exposure...
  76. Tsou J, Galler J, Siegmund K, Laird P, Turla S, Cozen W, et al. Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma. Mol Cancer. 2007;6:70 pubmed
    ..lung; eight of these show highly significant hypermethylation in adenocarcinoma: CDH13, CDKN2A EX2, CDX2, HOXA1, OPCML, RASSF1, SFPR1, and TWIST1 (p-value < 0.0001)...
  77. Ruff J, Saffarini R, Ramoz L, Morrison L, Baker S, Laverty S, et al. Mouse fitness measures reveal incomplete functional redundancy of Hox paralogous group 1 proteins. PLoS ONE. 2017;12:e0174975 pubmed publisher
    Here we assess the fitness consequences of the replacement of the Hoxa1 coding region with its paralog Hoxb1 in mice (Mus musculus) residing in semi-natural enclosures...
  78. Taniguchi T, Ohtani T, Nakatani S, Hayashi K, Yamaguchi O, Komuro I, et al. Impact of Body Size on Inferior Vena Cava Parameters for Estimating Right Atrial Pressure: A Need for Standardization?. J Am Soc Echocardiogr. 2015;28:1420-7 pubmed publisher
    ..cutoff point of IVCDmax for predicting RAP of ≥ 10 mm Hg was significantly larger in patients with higher BSAs than in those with lower BSAs (21 vs 17 mm, P = .0342)...
  79. Singh S, Rajput Y, Barui A, Sharma R, Datta T. Fat accumulation in differentiated brown adipocytes is linked with expression of Hox genes. Gene Expr Patterns. 2016;20:99-105 pubmed publisher
    ..In presence of these inducing agents, lipid accumulation as well as expression of HoxA1, HoxA5, HoxC4 &HoxC8 markedly enhanced...
  80. Masser D, Hadad N, Porter H, Stout M, Unnikrishnan A, Stanford D, et al. Analysis of DNA modifications in aging research. GeroScience. 2018;40:11-29 pubmed publisher
    ..sequencing (WGBS), bisulfite oligonucleotide capture sequencing (BOCS), and bisulfite amplicon sequencing (BSAS), cytosine modifications can now be readily analyzed with base-specific, absolute quantitation at both cytosine-..
  81. LaBelle C, Han S, Bergeron A, Samet J. Office-Based Opioid Treatment with Buprenorphine (OBOT-B): Statewide Implementation of the Massachusetts Collaborative Care Model in Community Health Centers. J Subst Abuse Treat. 2016;60:6-13 pubmed publisher
    We describe a Massachusetts Bureau of Substance Abuse Services' (BSAS) initiative to disseminate the office-based opioid treatment with buprenorphine (OBOT-B) Massachusetts Model from its development at Boston Medical Center (BMC) to its ..
  82. Maeshima S, Okazaki H, Okamoto S, Mizuno S, Asano N, Tsunoda T, et al. Dysphagia Following Putaminal Hemorrhage at a Rehabilitation Hospital. J Stroke Cerebrovasc Dis. 2016;25:389-96 pubmed publisher
    ..Bedside swallowing assessments (BSAs) were conducted and results were evaluated relative to the information obtained on computed tomography imaging, ..
  83. van Ohlen M, Herfurth A, Kerbstadt H, Wittstock U. Cyanide detoxification in an insect herbivore: Molecular identification of β-cyanoalanine synthases from Pieris rapae. Insect Biochem Mol Biol. 2016;70:99-110 pubmed publisher
    ..cDNAs designated PrBSAS1-PrBSAS3 which encode proteins with similarity to β-substituted alanine synthases (BSAS). Characterization of recombinant PrBSAS1-PrBSAS3 shows that they possess β-cyanoalanine activity...
  84. De Kumar B, Parker H, PARRISH M, Lange J, Slaughter B, Unruh J, et al. Dynamic regulation of Nanog and stem cell-signaling pathways by Hoxa1 during early neuro-ectodermal differentiation of ES cells. Proc Natl Acad Sci U S A. 2017;114:5838-5845 pubmed publisher
    i>Homeobox a1 (Hoxa1) is one of the most rapidly induced genes in ES cell differentiation and it is the earliest expressed Hox gene in the mouse embryo...
  85. Paraguison R, Higaki K, Sakamoto Y, Hashimoto O, Miyake N, Matsumoto H, et al. Polyhistidine tract expansions in HOXA1 result in intranuclear aggregation and increased cell death. Biochem Biophys Res Commun. 2005;336:1033-9 pubmed
    b>HOXA1 gene is part of a cluster of homeotic selector genes that regulates the anteroposterior patterning of mammals during embryonic development...
  86. Chen Y, Sakamuru S, Huang R, Reese D, Xia M. Identification of compounds that modulate retinol signaling using a cell-based qHTS assay. Toxicol In Vitro. 2016;32:287-96 pubmed publisher
    ..When evaluated in the P19 pluripotent cell, these compounds were found to affect the expression of the Hoxa1 gene that is essential for embryo body patterning...
  87. Bosley T, Salih M, Alorainy I, Oystreck D, Nester M, Abu Amero K, et al. Clinical characterization of the HOXA1 syndrome BSAS variant. Neurology. 2007;69:1245-53 pubmed
    The Bosley-Salih-Alorainy syndrome (BSAS) variant of the congenital human HOXA1 syndrome results from autosomal recessive truncating HOXA1 mutations...
  88. Abu Amero K, Kondkar A, Salih M, Alorainy I, Khan A, Oystreck D, et al. Partial chromosome 7 duplication with a phenotype mimicking the HOXA1 spectrum disorder. Ophthalmic Genet. 2013;34:90-6 pubmed publisher
    ..a patient with bilateral Duane retraction syndrome and hearing impairment resulting in a phenotype resembling the HOXA1 spectrum disorder...
  89. Chen L, Hu N, Wang C, Zhao H, Gu Y. Long non-coding RNA CCAT1 promotes multiple myeloma progression by acting as a molecular sponge of miR-181a-5p to modulate HOXA1 expression. Cell Cycle. 2018;17:319-329 pubmed publisher
    ..In addition, CCAT1 positively regulated HOXA1 expression through sponging miR-181a-5p in MM cells...
  90. Paraguison R, Higaki K, Yamamoto K, Matsumoto H, Sasaki T, Kato N, et al. Enhanced autophagic cell death in expanded polyhistidine variants of HOXA1 reduces PBX1-coupled transcriptional activity and inhibits neuronal differentiation. J Neurosci Res. 2007;85:479-87 pubmed
    b>HOXA1 is a member of the homeobox gene family and is involved in early brain development...
  91. Delval S, Taminiau A, Lamy J, Lallemand C, Gilles C, Noel A, et al. The Pbx interaction motif of Hoxa1 is essential for its oncogenic activity. PLoS ONE. 2011;6:e25247 pubmed publisher
    b>Hoxa1 belongs to the Hox family of homeodomain transcription factors involved in patterning embryonic territories and governing organogenetic processes...
  92. Song R, Zou L, Zhong R, Zheng X, Zhu B, Chen W, et al. An integrated meta-analysis of two variants in HOXA1/HOXB1 and their effect on the risk of autism spectrum disorders. PLoS ONE. 2011;6:e25603 pubmed publisher
    b>HOXA1 and HOXB1 have been strongly posed as candidate genes for autism spectrum disorders (ASD) given their important role in the development of hindbrain...