HOOK3

Summary

Gene Symbol: HOOK3
Description: hook microtubule tethering protein 3
Alias: HK3, protein Hook homolog 3, h-hook3, hHK3, hook homolog 3
Species: human
Products:     HOOK3

Top Publications

  1. Walenta J, Didier A, Liu X, Kramer H. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J Cell Biol. 2001;152:923-34 pubmed
    ..Human Hook3 bound to Golgi membranes in vitro and was enriched in the cis-Golgi in vivo...
  2. Shotland Y, Kr mer H, Groisman E. The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking. Mol Microbiol. 2003;49:1565-76 pubmed
    ..Here, we establish that SpiC targets the function of Hook3, a mammalian protein implicated in cellular trafficking...
  3. Kr mer H, Phistry M. Genetic analysis of hook, a gene required for endocytic trafficking in drosophila. Genetics. 1999;151:675-84 pubmed
    ..The importance of all three domains for Hook function was confirmed by their conservation between two Drosophila and two human Hook proteins...
  4. Xu L, Sowa M, Chen J, Li X, Gygi S, Harper J. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol Biol Cell. 2008;19:5059-71 pubmed publisher
    ..complex, containing FTS, members of the microtubule-binding Hook family of coiled-coil proteins (Hook1, Hook2, and Hook3), and a previously uncharacterized 107-kDa protein, FTS and Hook Interacting Protein (FHIP)...
  5. Sano H, Ishino M, KRAMER H, Shimizu T, Mitsuzawa H, Nishitani C, et al. The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A. J Biol Chem. 2007;282:7973-81 pubmed
    ..In the current study, we have identified a microtubule-binding protein, Hook3, as a novel interacting partner of SR-A...
  6. Fedorova M, Krasnov G, Lukyanova E, Zaretsky A, Dmitriev A, Melnikova N, et al. The CIMP-high phenotype is associated with energy metabolism alterations in colon adenocarcinoma. BMC Med Genet. 2019;20:52 pubmed publisher
    ..Upregulation of multiple genes involved in glycolysis and related processes (ENO2, PFKP, HK3, PKM, ENO1, HK2, PGAM1, GAPDH, ALDOA, GPI, TPI1, and HK1) was revealed in CIMP-high tumors compared to non-CIMP ..
  7. Dwivedi D, Kumari A, Rathi S, Mylavarapu S, Sharma M. The dynein adaptor Hook2 plays essential roles in mitotic progression and cytokinesis. J Cell Biol. 2019;: pubmed publisher
    ..Mammals express three Hook paralogs, namely Hook1, Hook2, and Hook3, that have distinct subcellular localizations and expectedly, distinct cellular functions...
  8. Olenick M, Dominguez R, Holzbaur E. Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons. J Cell Biol. 2019;218:220-233 pubmed publisher
    ..decrease in the flux and processivity of BDNF-Qdots along the mid-axon, an effect specific for Hook1 but not Hook3. Hook1 depletion inhibited BDNF trafficking to the soma and blocked downstream BDNF- and TrkB-dependent signaling ..
  9. Fernández Coto D, Gil J, Hernandez A, Herrera Goepfert R, Castro Romero I, Hernandez Marquez E, et al. Quantitative proteomics reveals proteins involved in the progression from non-cancerous lesions to gastric cancer. J Proteomics. 2018;186:15-27 pubmed publisher
    ..with down-regulation of SIRT3 and SIRT5, and overexpression of enzymes supporting the glycolytic phenotype, such as HK3 and PCK2...

More Information

Publications36

  1. Suh S, Kim Y, Goh T, Jeong D, Lee C, Jang J, et al. mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas. Yonsei Med J. 2018;59:746-753 pubmed publisher
    ..In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC without BRAF mutations...
  2. Cavalcante I, Zerbini M, Alencar G, Mariani B, Buchpiguel C, Almeida M, et al. High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3. Acta Radiol. 2016;57:370-7 pubmed publisher
    ..between 18F-FDG high uptake and the expression levels of the glycolytic pathway components GLUT1, HK1, HK2, and HK3 in PMAH. We selected 12 patients undergoing surgery for PMAH who had preoperatively undergone 18F-FDG PET/CT...
  3. Gao H, Luo X, Chen X, Wang J. Identification of key genes affecting disease free survival time of pediatric acute lymphoblastic leukemia based on bioinformatic analysis. Blood Cells Mol Dis. 2015;54:38-43 pubmed publisher
    ..For the 75 key genes, 27 disease risk sub-pathways were identified, and HK3, HNMT, SULT2B1, KYNU, and PTGS2 were the significant key genes which were enriched in these sub-pathways...
  4. Chen C, Liu C, Chen G, Andrews J, Arnold A, Dreyfus J, et al. Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet. 2014;23:3327-42 pubmed publisher
    ..We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8...
  5. Perrin Cocon L, Aublin Gex A, Diaz O, Ramière C, Peri F, Andre P, et al. Toll-like Receptor 4-Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from p38-Dependent Stabilization of HIF-1? and Increased Hexokinase II Expression. J Immunol. 2018;201:1510-1521 pubmed publisher
    ..LPS strongly enhanced the expression of HK2, whereas HK3 was reduced, HK1 remained unchanged, and HK4 was not expressed...
  6. Urnavicius L, Lau C, Elshenawy M, Morales Ríos E, Motz C, Yildiz A, et al. Cryo-EM shows how dynactin recruits two dyneins for faster movement. Nature. 2018;554:202-206 pubmed publisher
    ..Whereas BICD2 is biased towards recruiting a single dynein, the adaptors BICDR1 and HOOK3 predominantly recruit two dyneins...
  7. Liu J, Tong S, Qiu L, Ying S, Feng M. Two histidine kinases can sense different stress cues for activation of the MAPK Hog1 in a fungal insect pathogen. Environ Microbiol. 2017;19:4091-4102 pubmed publisher
    ..Of those, only Group III (HK3) homologues in some fungi can sense osmotic, fungicidal and/or oxidative cues upstream of the signalling MAPK Hog1 ..
  8. Sambarey A, Devaprasad A, Mohan A, Ahmed A, Nayak S, Swaminathan S, et al. Unbiased Identification of Blood-based Biomarkers for Pulmonary Tuberculosis by Modeling and Mining Molecular Interaction Networks. EBioMedicine. 2017;15:112-126 pubmed publisher
    ..as additional validation on independent patient samples, and identify a signature comprising 10 genes - FCGR1A, HK3, RAB13, RBBP8, IFI44L, TIMM10, BCL6, SMARCD3, CYP4F3 and SLPI, that can discriminate between TB and healthy ..
  9. Shi E, Chmielecki J, Tang C, Wang K, Heinrich M, Kang G, et al. FGFR1 and NTRK3 actionable alterations in "Wild-Type" gastrointestinal stromal tumors. J Transl Med. 2016;14:339 pubmed
    ..Two tumors harbored FGFR1 gene fusions (FGFR1-HOOK3, FGFR1-TACC1) and one harbored an ETV6-NTRK3 fusion that responded to TRK inhibition...
  10. Lee I, Olenick M, Boczkowska M, Franzini Armstrong C, Holzbaur E, Dominguez R. A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity. Nat Commun. 2018;9:986 pubmed publisher
    ..binding studies map these interactions to a conserved helix within LIC1 and to N-terminal fragments of Hook1, Hook3, BICD2, and Spindly...
  11. Mao J, Li W, Mi B, Dawuda M, CALDERON URREA A, Ma Z, et al. Different exogenous sugars affect the hormone signal pathway and sugar metabolism in "Red Globe" (Vitis vinifera L.) plantlets grown in vitro as shown by transcriptomic analysis. Planta. 2017;246:537-552 pubmed publisher
    ..on the balanced expression of key potential candidate genes related to hormones (TCP15, LOG3, IPT3, ETR1, HK2, HK3, CKX7, SPY, GH3s, MYBH, AGB1, MKK2, PP2C, PYL, ABF, SnRK, etc...
  12. Harami Papp H, Pongor L, Munkácsy G, Horváth G, Nagy Ã, Ambrus A, et al. TP53 mutation hits energy metabolism and increases glycolysis in breast cancer. Oncotarget. 2016;7:67183-67195 pubmed publisher
    ..Top up-regulated metabolic genes include glycolytic enzymes (e.g. HK3, GPI, GAPDH, PGK1, ENO1), glycolysis regulator (PDK1) and pentose phosphate pathway enzymes (PGD, TKT, RPIA)...
  13. Vartanian A, Agnihotri S, Wilson M, Burrell K, Tonge P, Alamsahebpour A, et al. Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma. Oncotarget. 2016;7:69518-69535 pubmed publisher
    ..GBM, we showed that inducible knockdown of HK2 altered tumor metabolism, which could not be recapitulated by HK1 or HK3 loss...
  14. Pudova E, Kudryavtseva A, Fedorova M, Zaretsky A, Shcherbo D, Lukyanova E, et al. HK3 overexpression associated with epithelial-mesenchymal transition in colorectal cancer. BMC Genomics. 2018;19:113 pubmed publisher
    ..genes with significant correlation coefficients, which included 21 EMT-related genes and a single glycolytic gene, HK3. The mRNA level of these genes was measured in 78 paired colorectal cancer samples by quantitative polymerase chain ..
  15. Krasnov G, Dmitriev A, Sadtritdinova A, Fedorova M, Snezhkina A, Melnikova N, et al. [Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods]. Biofizika. 2015;60:1050-6 pubmed
    ..01), that could be explained by common deregulation mechanisms of these genes in colorectal tumors. The HK3 expression level was significantly increased in 60% of samples...
  16. Kudryavtseva A, Fedorova M, Zhavoronkov A, Moskalev A, Zasedatelev A, Dmitriev A, et al. Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells. BMC Genet. 2016;17:156 pubmed publisher
    ..The purpose of the present study was to investigate the effect of silencing of hexokinase genes (HK1, HK2, and HK3) in colorectal cancer (HT-29, SW 480, HCT-15, RKO, and HCT 116) and melanoma (MDA-MB-435S and SK-MEL-28) cell lines ..
  17. Kaiser F, Kaufmann S, Zerrahn J. IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3. J Cell Sci. 2004;117:1747-56 pubmed
    ..We identified the cytoplasmic linker molecule hook3 as an interactor for IIGP by yeast two-hybrid screening...
  18. Simpson F, Martin S, Evans T, Kerr M, James D, Parton R, et al. A novel hook-related protein family and the characterization of hook-related protein 1. Traffic. 2005;6:442-58 pubmed
    ..We propose that HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains. ..
  19. Melling N, Harutyunyan L, Hube Magg C, Kluth M, Simon R, Lebok P, et al. High-Level HOOK3 Expression Is an Independent Predictor of Poor Prognosis Associated with Genomic Instability in Prostate Cancer. PLoS ONE. 2015;10:e0134614 pubmed publisher
    Hook microtubule-tethering protein 3 (HOOK3) is an adaptor protein for microtubule-dependent intracellular vesicle and protein trafficking...
  20. Darling M, Tsai S, Jackson Boeters L, Daley T, Diamandis E. Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors. Int J Biol Markers. 2006;21:201-5 pubmed
    ..It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer. Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland...
  21. Lin Y, Wu Y, Wang Y, Yao Z, Tang J, Wang R, et al. Spatio-temporal expression of Hexokinase-3 in the injured female rat spinal cords. Neurochem Int. 2018;113:23-33 pubmed publisher
    Hexokinase-3 (HK3) is a member of hexokinase family, which can catalyze the first step of glucose metabolism...
  22. Xie F, He M, He L, Liu K, Li M, Hu G, et al. Bipartite network analysis reveals metabolic gene expression profiles that are highly associated with the clinical outcomes of acute myeloid leukemia. Comput Biol Chem. 2017;67:150-157 pubmed publisher
    ..Notably, the expression profiles of ALAS2, BCAT1, BLVRB, and HK3 showed distinct differences between the low-risk and high-risk patients...
  23. Schroeder C, Vale R. Assembly and activation of dynein-dynactin by the cargo adaptor protein Hook3. J Cell Biol. 2016;214:309-18 pubmed publisher
    ..Here, we examined how Hook3, a cargo adaptor involved in Golgi and endosome transport, forms a motile dynein-dynactin complex...
  24. Olenick M, Tokito M, Boczkowska M, Dominguez R, Holzbaur E. Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction. J Biol Chem. 2016;291:18239-51 pubmed publisher
    ..Here we investigate the role of mammalian Hook proteins, Hook1 and Hook3, as potential motor adaptors...
  25. Herrmann L, Wiegmann C, Arsalan Werner A, Hilbrich I, Jäger C, Flach K, et al. Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PLoS ONE. 2015;10:e0119423 pubmed publisher
    ..In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes...
  26. Ciampi R, Giordano T, Wikenheiser Brokamp K, Koenig R, Nikiforov Y. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocr Relat Cancer. 2007;14:445-52 pubmed
    ..of RET coding for the tyrosine kinase (TK) domain of the receptor to the 5'-portion of the Homo sapiens hook homolog 3 (HOOK3) gene...
  27. Ge X, Frank C, Calderon de Anda F, Tsai L. Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron. 2010;65:191-203 pubmed publisher
    ..Here we demonstrate that trafficking of pericentriolar satellites requires the interaction between Hook3 and Pericentriolar Material 1 (PCM1). Hook3, previously shown to link the centrosome and the nucleus in C...