HOOK3

Summary

Gene Symbol: HOOK3
Description: hook microtubule-tethering protein 3
Alias: HK3, h-hook3, hHK3, hook homolog 3, protein Hook homolog 3
Species: human

Top Publications

  1. pmc Genetic analysis of hook, a gene required for endocytic trafficking in drosophila
    H Kramer
    Center for Basic Neuroscience, Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    Genetics 151:675-84. 1999
  2. ncbi Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Mol Biol 362:1094-107. 2006
  3. ncbi Expanded human tissue kallikrein family--a novel panel of cancer biomarkers
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ont, Canada
    Tumour Biol 23:185-92. 2002
  4. ncbi Human tissue kallikrein 9: production of recombinant proteins and specific antibodies
    Nader Memari
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 387:733-40. 2006
  5. ncbi Design of new and sensitive fluorogenic substrates for human kallikrein hK3 (prostate-specific antigen) derived from semenogelin sequences
    Sophie Réhault
    Laboratory of Enzymology and Protein Chemistry, INSERM EMI U 00 10, University Francois Rabelais, 2bis Boulevard Tonnellé, 37032 Tours Cedex, France
    Biochim Biophys Acta 1596:55-62. 2002
  6. ncbi Human tissue kallikrein gene family: applications in cancer
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Cancer Lett 224:1-22. 2005
  7. pmc Circulating microRNAs and Kallikreins before and after Radical Prostatectomy: Are They Really Prostate Cancer Markers?
    Maria Giulia Egidi
    Department of Medical Surgical Sciences and Public Health, Faculty of Medicine and Surgery, University of Perugia, Loc S Andrea delle Fratte, 06156 Perugia, Italy
    Biomed Res Int 2013:241780. 2013
  8. ncbi Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Biol Chem 281:25678-88. 2006
  9. ncbi Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization
    A Colosimo
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita di Roma Tor Vergata, Italy
    Cytogenet Cell Genet 74:187-8. 1996
  10. ncbi A novel hook-related protein family and the characterization of hook-related protein 1
    Fiona Simpson
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Traffic 6:442-58. 2005

Research Grants

  1. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
  2. Epigenetic Effects of Resveratrol
    Edward Sauter; Fiscal Year: 2007
  3. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
  4. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2007
  5. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
  6. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
  7. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
  8. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003

Scientific Experts

  • Michaela S Banck
  • K M Slawin
  • M R Darling
  • V Vaisanen
  • Salvatore Patanè
  • HELMUT KRAMER
  • P S Nelson
  • Fiona Simpson
  • F Mannello
  • E R Sauter
  • Eleftherios Diamandis
  • William S Stone
  • Chunyan He
  • Johan Malm
  • Judith A Clements
  • Hyun S Shvartsman
  • H Lilja
  • Charlotte Becker
  • Hitomi Sano
  • M S Saedi
  • Mekdes Debela
  • Yan He
  • Constantina D Petraki
  • Carla A Borgono
  • Viktor Magdolen
  • Wolfram Bode
  • Iacovos P Michael
  • Ding Liu
  • Fernanda Marconi Roversi
  • Maria Giulia Egidi
  • Yingying Qin
  • Elena A Federzoni
  • Linda Grass
  • Xuecai Ge
  • Xing e He
  • Jing Zhao
  • Chris R Guthrie
  • Wolfgang Weber
  • George M Yousef
  • Joseph R Sterbis
  • Sophie Réhault
  • Gregory J Mize
  • Lai Xu
  • Noriko Nakamura
  • Michele Brillard-Bourdet
  • Miltiadis Paliouras
  • Raffaele Ciampi
  • Lindsay Ewan King
  • Peter Goettig
  • Silke Stertz
  • Nader Memari
  • Nathalie Beaufort
  • Margrita H Slagter
  • Christina V Obiezu
  • Frank Kaiser
  • Eiji Yasumoto
  • Andreas Scorilas
  • Yoram Shotland
  • Antoninus Soosaipillai
  • G M Yousef
  • Francis Gauthier
  • Luiz Juliano
  • Maryam Zarghooni
  • Thierry Moreau
  • F Gauthier
  • Dulcineia Martins de Albuquerque
  • Danilo Zampini
  • Fernando Ferreira da Costa
  • Maria Rita Serva
  • En Bo Wang
  • Ettore Mearini
  • Sara Teresinha Olalla Saad
  • Hua Qiao Tan
  • Gabriella Guelfi
  • Ana Flávia Brugnerotto
  • Carolina Lanaro
  • Luca Mechelli
  • Giovanni Cochetti
  • Ying Lu
  • Anderson Ferreira da Cunha
  • Wei Lin Chen
  • Zhi ming Zhang
  • João Agostinho Machado-Neto
  • Marcelo Falsarella Carazzolle
  • Yang Guang Li
  • Xiaoyan Liang
  • Mei Sun
  • Bo Zhang
  • Bob Lowenberg
  • Jielin Sun

Detail Information

Publications65

  1. pmc Genetic analysis of hook, a gene required for endocytic trafficking in drosophila
    H Kramer
    Center for Basic Neuroscience, Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9111, USA
    Genetics 151:675-84. 1999
    ..The importance of all three domains for Hook function was confirmed by their conservation between two Drosophila and two human Hook proteins...
  2. ncbi Crystal structures of human tissue kallikrein 4: activity modulation by a specific zinc binding site
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, 82152 Martinsried, Germany
    J Mol Biol 362:1094-107. 2006
    ..hK4 is predominantly expressed in prostate, activates hK3/PSA, and is up-regulated in prostate and ovarian cancer...
  3. ncbi Expanded human tissue kallikrein family--a novel panel of cancer biomarkers
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ont, Canada
    Tumour Biol 23:185-92. 2002
    ..In addition to prostate-specific antigen (PSA, hK3), which is an established tumor marker for prostate cancer diagnosis and follow-up, and human glandular kallikrein (..
  4. ncbi Human tissue kallikrein 9: production of recombinant proteins and specific antibodies
    Nader Memari
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1L5, ON, Canada
    Biol Chem 387:733-40. 2006
    ..Two tissue kallikreins, namely hK2 and hK3 (prostate-specific antigen, PSA), are currently used as serological biomarkers of prostate cancer...
  5. ncbi Design of new and sensitive fluorogenic substrates for human kallikrein hK3 (prostate-specific antigen) derived from semenogelin sequences
    Sophie Réhault
    Laboratory of Enzymology and Protein Chemistry, INSERM EMI U 00 10, University Francois Rabelais, 2bis Boulevard Tonnellé, 37032 Tours Cedex, France
    Biochim Biophys Acta 1596:55-62. 2002
    Human kallikrein hK3 (prostate-specific antigen) is a chymotrypsin-like serine protease which is widely used in the diagnosis of prostate cancer...
  6. ncbi Human tissue kallikrein gene family: applications in cancer
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont, Canada M5G 1X5
    Cancer Lett 224:1-22. 2005
    ..PSA (hK3) is one of the human kallikreins, and is the most useful tumor marker for prostate cancer screening, diagnosis, ..
  7. pmc Circulating microRNAs and Kallikreins before and after Radical Prostatectomy: Are They Really Prostate Cancer Markers?
    Maria Giulia Egidi
    Department of Medical Surgical Sciences and Public Health, Faculty of Medicine and Surgery, University of Perugia, Loc S Andrea delle Fratte, 06156 Perugia, Italy
    Biomed Res Int 2013:241780. 2013
    The aim of our study was to monitor serum levels of two miRNAs (miR-21 and miR-141) and three KLKs (hK3/PSA, hK11, and hK13) before and 1, 5, and 30 days after radical prostatectomy, in order to characterize their fluctuations after ..
  8. ncbi Specificity profiling of seven human tissue kallikreins reveals individual subsite preferences
    Mekdes Debela
    Max Planck Institut fur Biochemie, Proteinase Research Group, Am Klopferspitz 18, D 82152 Martinsried, Germany
    J Biol Chem 281:25678-88. 2006
    ..For example, the prostate-specific antigen (PSA or hK3) serves as tumor marker and is used to monitor therapy response...
  9. ncbi Assignment of the hexokinase type 3 gene (HK3) to human chromosome band 5q35.3 by somatic cell hybrids and in situ hybridization
    A Colosimo
    Dipartimento di Sanita Pubblica e Biologia Cellulare, Universita di Roma Tor Vergata, Italy
    Cytogenet Cell Genet 74:187-8. 1996
  10. ncbi A novel hook-related protein family and the characterization of hook-related protein 1
    Fiona Simpson
    Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
    Traffic 6:442-58. 2005
    ..We propose that HkRP1 is involved in the process of tubulation of sorting nexin-1 positive membranes from early endosome subdomains...
  11. ncbi Human kallikrein 14: a new potential biomarker for ovarian and breast cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer Res 63:9032-41. 2003
    ..is a recently discovered member of the tissue kallikrein family of secreted serine proteases, which includes hK3/prostate-specific antigen, the best cancer biomarker to date...
  12. ncbi Cytotoxic activity of deferiprone, maltol and related hydroxyketones against human tumor cell lines
    Eiji Yasumoto
    Department of Dental Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Anticancer Res 24:755-62. 2004
    Hydroxyketone chelators, deferiprone (HK1), maltol (HK3) and their related compounds (HK2, 4-8), were characterized for their cytotoxic profiles against oral human normal and tumor cells...
  13. ncbi Cellular distribution of human tissue kallikreins: immunohistochemical localization
    Constantina D Petraki
    Department of Pathology, Evangelismos Hospital, GR 10676 Athens, Greece, and Depament of Laboratory Medicine and Pathobiology, University of Toronto, Canada
    Biol Chem 387:653-63. 2006
    ..revealed in a variety of tissues, indicating that no protein is tissue-specific (except for hK2 and hK3, which have tissue-restricted expression)...
  14. ncbi Effects of long-term androgen administration on breast tissue of female-to-male transsexuals
    Margrita H Slagter
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada
    J Histochem Cytochem 54:905-10. 2006
    ..of female-to-male transsexuals and to study the immunohistochemical expression of three human tissue kallikreins, hK3 (PSA), hK6, and hK10...
  15. doi Assembly of trimeric polyoxovanadate aggregates based on [MnV13O38]7- building blocks and lanthanide cations
    Ding Liu
    Key Laboratory of Polyoxometalate Science of Ministry of Education, Department of Chemistry, Northeast Normal University, Changchun, Jilin 130024, P R China
    Dalton Trans 42:14445-53. 2013
    ..on 1:13 anions [MnV13O38](7-) with lanthanide cations Ln(3+) (Ln = La, Ce and Nd) and pyridine-3-carboxylic acid: HK3{[Ln(H2O)4]6[MnV13O38]3(SO4)2}·3(C6H6NO2)·nH2O (Ln = La 1, Nd 3; n = 33 for 1, 20 for 3), H(2.5)K(1...
  16. doi Gene expression analysis of the Brazilian type of hereditary persistence of fetal hemoglobin: identification of genes that could be related to γ-globin activation
    Fernanda Marconi Roversi
    Hematology and Hemotherapy Center, University of Campinas UNICAMP, Campinas, Sao Paulo, Brasil
    Hemoglobin 37:516-35. 2013
    ..expression of MIER1, known for the recruitment of chromatin remodeling enzymes, and decreased expression of HOOK3. These data suggest new genes that may play a role in globin gene regulation, γ-globin gene expression and ..
  17. pmc PU.1 is linking the glycolytic enzyme HK3 in neutrophil differentiation and survival of APL cells
    Elena A Federzoni
    Experimental Oncology Hematology, Department of Clinical Research, University of Bern, Bern, Switzerland
    Blood 119:4963-70. 2012
    ..1-regulated genes involved in cell survival. We now identified the glycolytic enzyme hexokinase 3 (HK3), a gene with cytoprotective functions, as transcriptional target of PU.1...
  18. pmc ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure
    Yingying Qin
    Center for Reproductive Medicine, Provincial Hospital affiliated to Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, The Key Laboratory for Reproductive Endocrinology of Ministry of Education, Shandong Provincial Key Laboratory of Reproductive Medicine, Jinan, China
    Orphanet J Rare Dis 7:5. 2012
    ..We sought to determine if sequence variants previously associated with age at natural menopause (AANM) or early menopause (EM) contribute as well to genetic susceptibility to POF...
  19. pmc SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans
    Chris R Guthrie
    Geriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA
    Hum Mol Genet 18:1825-38. 2009
    ..The human genome encodes three homologs of ZYG-12: HOOK1, HOOK2 and HOOK3. Of these, the human ortholog of SUT-2 (MSUT-2) binds only to HOOK2 suggesting the interaction between SUT-2 and ..
  20. ncbi Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum
    Silke Stertz
    Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg, D 79008 Freiburg, Germany
    J Interferon Cytokine Res 26:650-60. 2006
    ..Overexpression of MxA leads to a characteristic reorganization of the associated membranes. Interestingly, Hook3, mannose-6-phosphate receptor, and Lamp-1, which normally accumulate in cis- Golgi, endosomes, and lysosomes, ..
  21. pmc Hook3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis
    Xuecai Ge
    Picower Institute for Learning and Memory, Department of Brain and Cognitive, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 46, Room 4235A, Cambridge, MA 02139, USA
    Neuron 65:191-203. 2010
    ..Here we demonstrate that trafficking of pericentriolar satellites requires the interaction between Hook3 and Pericentriolar Material 1 (PCM1). Hook3, previously shown to link the centrosome and the nucleus in C...
  22. ncbi Coordinated steroid hormone-dependent and independent expression of multiple kallikreins in breast cancer cell lines
    Miltiadis Paliouras
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, M5G 1X5 Toronto, ON, Canada
    Breast Cancer Res Treat 102:7-18. 2007
    ..Breast cancer cell lines were treated with various steroid hormones and kallikrein (KLK/hK) expression of hK3 (prostate-specific antigen, PSA), hK5, hK6, hK7, hK8, hK10, hK11, hK13, and hK14 was analyzed at the RNA level via ..
  23. ncbi Free and total human glandular kallikrein 2 in patients with prostate cancer
    Ville Vaisanen
    Department of Biotechnology, University of Turku, Turku, Finland
    Urology 68:219-25. 2006
    The use of prostate-specific antigen (PSA, hK3) results in the overdiagnosis and overtreatment of prostate cancer...
  24. pmc Spermatogenic cell-specific type 1 hexokinase is the predominant hexokinase in sperm
    Noriko Nakamura
    Laboratory of Reproductive and Developmental Toxicology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, USA
    Mol Reprod Dev 75:632-40. 2008
    ..of expression of the individual variant transcripts or of the other members of the hexokinase gene family (Hk2, Hk3, and Gck) in spermatogenic cells remains uncertain...
  25. ncbi Human kallikrein 3 (prostate specific antigen) and human kallikrein 5 expression in salivary gland tumors
    M R Darling
    Division of Oral Pathology, Department of Pathology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Int J Biol Markers 21:201-5. 2006
    ..It has also been shown to be a potential biomarker for breast, ovarian and testicular cancer. Human kallikrein 3 (hK3; prostate-specific antigen) is the most useful marker for adenocarcinoma of the prostate gland...
  26. doi Knockdown of HBx by RNAi inhibits proliferation and enhances chemotherapy-induced apoptosis in hepatocellular carcinoma cells
    Yan He
    The Liver Disease Research Institute, Second Xiangya Hospital, Central South University, No 139 Renmin Road, 410011, Changsha, Hunan Province, China
    Med Oncol 27:1227-33. 2010
    ..expression shRNA eukaryotic vector targeting HBx gene-21543 cell lines (MHCC97-H of expressing shRNA against HBx), HK3 cell lines (MHCC97-H by transfected with pshRNA-MOCK)...
  27. doi The maize HMGA protein is localized to the nucleolus and can be acetylated in vitro at its globular domain, and phosphorylation by CDK reduces its binding activity to AT-rich DNA
    Jing Zhao
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    Biochim Biophys Acta 1789:751-7. 2009
    ..CDK phosphorylation sites situated between AT-hook3 and AT-hook4 were strongly phosphorylated by a SUC1-associated kinase; no in vitro phosphorylation is evident for ..
  28. doi Prostate specific antigen: one out of five disulfide bridges determines inactivation by reduction
    Wolfgang Weber
    Institut fur Biochemie und Molekularbiologie I, Universitatsklinikum Hamburg Eppendorf, D 20246 Hamburg, Germany
    Biochem Biophys Res Commun 379:1101-6. 2009
    PSA (kallikrein hK3) proteolytic activity proved highly sensitive to reducing agents like dithiothreitol (DTT) and dihydrolipoic acid while beta-mercaptoethanol and glutathione were less effective...
  29. pmc An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex
    Lai Xu
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 19:5059-71. 2008
    ..complex, containing FTS, members of the microtubule-binding Hook family of coiled-coil proteins (Hook1, Hook2, and Hook3), and a previously uncharacterized 107-kDa protein, FTS and Hook Interacting Protein (FHIP)...
  30. doi Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2
    Gregory J Mize
    Department of Urology, University of Washington, Box 356510, Seattle, WA 98195, USA
    Mol Cancer Res 6:1043-51. 2008
    A major characteristic of prostate cancer is the elevation of serum levels of prostate-specific antigen (hK3) and hK2, which are tumor markers that correlate with advancing stages of disease...
  31. doi Prostate-specific antigen kallikrein: from prostate cancer to cardiovascular system
    Salvatore Patanè
    Cardiologia Nuovo Presidio Ospedaliero Cutroni Zodda Barcellona P d G Me AUSL5 Messina, Via Cattafi, 98051 Barcellona Pozzo di Gotto, Messina, Italy
    Eur Heart J 30:1169-70. 2009
    ..PSA), considered only an established marker for the detection of prostate cancer, has been identified as a member (hK3) of the human kallikrein family of serine proteases and now, it is known that PSA is not specific to prostate, ..
  32. pmc Genome-wide association studies identify loci associated with age at menarche and age at natural menopause
    Chunyan He
    Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Nat Genet 41:724-8. 2009
    ..3 (in the gene MCM8), 19q13.42 (in or near the gene BRSK1), 5q35.2 (in or near genes UIMC1 and HK3) and 6p24.2 (in the gene SYCP2L)...
  33. ncbi [Effect of HBx gene RNA interference combined with chemotherapy on hepatocellular carcinoma cells]
    Yan He
    Research Insititute of Liver Diseases, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 34:395-400. 2009
    ..To determine the influence of HBx gene RNA interference combined with chemotherapy on stable hepatocellular carcinoma cells growth and its apoptosis mechanism...
  34. ncbi HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma
    Raffaele Ciampi
    Department of Pathology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Endocr Relat Cancer 14:445-52. 2007
    ..of RET coding for the tyrosine kinase (TK) domain of the receptor to the 5'-portion of the Homo sapiens hook homolog 3 (HOOK3) gene...
  35. ncbi Human kallikrein 10 ELISA development and validation in breast cancer sera
    Lindsay Ewan King
    IBEX Pharmaceuticals, 5485 Pare, Montreal, Quebec, Canada
    Clin Biochem 40:1057-62. 2007
    ..10 (hK10) is a putative secreted serine protease belonging to the same gene family as prostate specific antigen (hK3; PSA). There is significant interest in measuring hK10 which may act as a tumor suppressor in some cancers...
  36. ncbi The microtubule-binding protein Hook3 interacts with a cytoplasmic domain of scavenger receptor A
    Hitomi Sano
    Department of Biochemistry, Sapporo Medical University School of Medicine, Sapporo 060 8556, Japan
    J Biol Chem 282:7973-81. 2007
    ..In the current study, we have identified a microtubule-binding protein, Hook3, as a novel interacting partner of SR-A...
  37. doi Higher expression of the androgen-regulated gene PSA/HK3 mRNA in prostate cancer tissues predicts biochemical recurrence-free survival
    Joseph R Sterbis
    Urology Service, Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    Clin Cancer Res 14:758-63. 2008
    ..We hypothesized that the assessment of well-defined AR transcriptional targets (e.g., PSA/HK3 mRNA) in CaP tissues will provide in vivo readout of AR dysfunctions...
  38. ncbi Human tissue kallikrein 5 is a member of a proteolytic cascade pathway involved in seminal clot liquefaction and potentially in prostate cancer progression
    Iacovos P Michael
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    J Biol Chem 281:12743-50. 2006
    ..site of each kallikrein and recombinant pro-hKs, we demonstrated that hK5 is able to activate pro-hK2 and pro-hK3. We then showed that, following their activation, hK5 can internally cleave and deactivate hK2 and hK3...
  39. ncbi Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates
    Michele Brillard-Bourdet
    Laboratory of Enzymology and Protein Chemistry, INSERM EMI U 00 10, University Francois Rabelais, Faculty of Medicine, Tours, France
    Eur J Biochem 269:390-5. 2002
    In addition to kallikrein hK3, a serine protease generally reported as PSA (prostate-specific antigen), at least two other enzymes in human seminal plasma also cleave synthetic peptidyl substrates derived from the sequence of human ..
  40. ncbi The role of molecular forms of prostate-specific antigen (PSA or hK3) and of human glandular kallikrein 2 (hK2) in the diagnosis and monitoring of prostate cancer and in extra-prostatic disease
    C Becker
    Dept of Clinical Chemistry, Lund University, Malmo University Hospital, Malmo, Sweden
    Crit Rev Clin Lab Sci 38:357-99. 2001
    Prostate-specific antigen (PSA or hK3) is a glandular kallikrein with abundant expression in the prostate that is widely used to detect and monitor prostate cancer (PCa), although the serum level is frequently elevated also in benign and ..
  41. pmc Prostate-specific antigen (PSA/hK3): a further player in the field of breast cancer diagnostics?
    F Mannello
    Libera Università Studi, Urbino, Italy
    Breast Cancer Res 3:238-43. 2001
    ..much information has been obtained about prostate-specific antigen (PSA, or human glandular kallikrein 3 [hK3]), a kallikrein-like serine protease that is the most valuable tumour marker for the screening, diagnosis and ..
  42. ncbi Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3
    S Rehault
    Laboratoire d Enzymologie et Chimie des Protéines, INSERM Université François Rabelais, Tours, France
    Eur J Biochem 268:2960-8. 2001
    ..To elucidate the putative biological role of prostatic kallikreins hK2 and hK3 (prostate-specific antigen) in tumour progression, we analyzed the degradation of IGFBP-2, -3, -4 and -5 by these ..
  43. pmc The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins
    J H Walenta
    Center for Basic Neuroscience and Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Cell Biol 152:923-34. 2001
    ..Human Hook3 bound to Golgi membranes in vitro and was enriched in the cis-Golgi in vivo...
  44. ncbi Detection of metastatic prostate cancer using a splice variant-specific reverse transcriptase-polymerase chain reaction assay for human glandular kallikrein
    K M Slawin
    Matsunaga Conte Prostate Cancer Research Center, Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA
    Cancer Res 60:7142-8. 2000
    ..a significant portion of the 3' untranslated region of the hKLK2 gene, with maximum nonhomology to both hK1 and hK3, was developed...
  45. ncbi Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor
    J Malm
    Section for Clinical Chemistry, Department of Laboratory Medicine, Lund University, University Hospital Malmo, Malmo, Sweden
    Prostate 45:132-9. 2000
    In semen, prostate-specific antigen (PSA or hK3) digests the gel proteins semenogelin I and II, resulting in liquefaction and the release of motile spermatozoa...
  46. ncbi The new human kallikrein gene family: implications in carcinogenesis
    E P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Trends Endocrinol Metab 11:54-60. 2000
    ..kallikrein], KLK2 (encoding hK2, previously known as human glandular kallikrein 1) and KLK3 [encoding hK3 or prostate-specific antigen (PSA)]...
  47. pmc Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostate-restricted expression
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 96:3114-9. 1999
    ..proteases, including protease M, pancreatic/renal kallikrein hK1, and the prostate-specific kallikreins hK2 and hK3 (PSA)...
  48. pmc Mapping of primary congenital lymphedema to the 5q35.3 region
    A L Evans
    Cardiological Sciences, St George s Hospital Medical School, London, United Kingdom
    Am J Hum Genet 64:547-55. 1999
    ..84 for this condition. A few of the positionally mapped genes in the 5q35 region that may potentially be involved in the etiology of this condition are CANX, FGFR4, HK3, and hnRPH1.
  49. ncbi The precursor form of the human kallikrein 2, a kallikrein homologous to prostate-specific antigen, is present in human sera and is increased in prostate cancer and benign prostatic hyperplasia
    M S Saedi
    Hybritech Incorporated, Beckman Coulter, Inc, San Diego, CA 92126, USA
    Clin Chem 44:2115-9. 1998
    Prostate-specific antigen (PSA, hK3) is a diagnostic marker for prostatic cancer but lacks the specificity to sufficiently distinguish between prostatic cancer and benign prostatic hyperplasia (BPH)...
  50. ncbi Serpin-derived peptide substrates for investigating the substrate specificity of human tissue kallikreins hK1 and hK2
    L Bourgeois
    Laboratory of Enzymology and Protein Chemistry, CNRS EP 117, University Francois Rabelais, 37032 Tours, France
    J Biol Chem 272:29590-5. 1997
    The third human tissue kallikrein to be identified, hK2, could be an alternate or complementary marker to kallikrein hK3 (prostate-specific antigen) for prostate diseases...
  51. ncbi Sequence of human hexokinase III cDNA and assignment of the human hexokinase III gene (HK3) to chromosome band 5q35.2 by fluorescence in situ hybridization
    H Furuta
    Department of Medicine, The University of Chicago, Chicago, Illinois, 60637, USA
    Genomics 36:206-9. 1996
    ..RNA blotting showed the presence of hexokinase III mRNA in liver and lung. Fluorescence in situ hybridization localized the human hexokinase III gene (HK3) to chromosome 5, band q35.2.
  52. ncbi Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients
    Maryam Zarghooni
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 35:225-31. 2002
    ..Our objective was to develop a highly sensitive immunoassay for hK6 and use it to examine the levels of hK6 in brain tissue extracts from Alzheimer's disease patients and control subjects...
  53. ncbi Interplay of human tissue kallikrein 4 (hK4) with the plasminogen activation system: hK4 regulates the structure and functions of the urokinase-type plasminogen activator receptor (uPAR)
    Nathalie Beaufort
    Unité de Défense Innée et Inflammation INSERM E0336, Département de Médecine Moléculaire, Institut Pasteur, F 75015 Paris, France
    Biol Chem 387:217-22. 2006
    ..previously shown to cleave and activate the pro-enzyme forms of prostate-specific antigen (PSA, tissue kallikrein hK3) and uPA...
  54. ncbi Biology of prostate-specific antigen
    Hans Lilja
    Department of Laboratory Medicine, Division of Clinical Chemistry, Lund University, University Hospital UMAS, Malmo, Sweden
    Urology 62:27-33. 2003
    The human kallikrein (hk) family, located on chromosome 19, encodes prostate-specific antigen (PSA [or hK3]), hK2, hK4, and hK15 (prostin), as well as other serine proteases...
  55. ncbi The tissue kallikrein family of serine proteases: functional roles in human disease and potential as clinical biomarkers
    Judith A Clements
    Hormone Dependent Cancer Program, Cluster for Molecular Biotechnology, School of Life Sciences and Science Research Centre, Queensland University of Technology, Brisbane, Australia
    Crit Rev Clin Lab Sci 41:265-312. 2004
    Prostate specific antigen (PSA) or human kallikrein 3 (hK3) has long been an effective biomarker for prostate cancer...
  56. ncbi Human tissue kallikreins: physiologic roles and applications in cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5 Canada
    Mol Cancer Res 2:257-80. 2004
    ..As a consequence, many kallikreins, in addition to hK3/PSA, have been identified as promising diagnostic and/or prognostic biomarkers for several cancer types, including ..
  57. ncbi Evidence for linkage between regulatory enzymes in glycolysis and schizophrenia in a multiplex sample
    William S Stone
    Harvard Medical School Department of Psychiatry at Massachusetts Mental Health Center, Boston, Massachusetts 02115, USA
    Am J Med Genet B Neuropsychiatr Genet 127:5-10. 2004
    ..2) achieved genome-wide significance (P = 0.04). In addition, hexokinase 3 (HK3; chromosome 5q35.3) was also suggestive of linkage (P = 0.09). For the European-American sample, PFKFB2 (1q32...
  58. ncbi IIGP, a member of the IFN inducible and microbial defense mediating 47 kDa GTPase family, interacts with the microtubule binding protein hook3
    Frank Kaiser
    Department of Immunology, Max Planck Institute for Infection Biology, Schumannstrasse 21 22, 10117 Berlin, Germany
    J Cell Sci 117:1747-56. 2004
    ..We identified the cytoplasmic linker molecule hook3 as an interactor for IIGP by yeast two-hybrid screening...
  59. ncbi Association of kallikrein expression in nipple aspirate fluid with breast cancer risk
    Edward R Sauter
    Department of Surgery, University of Missouri, Columbia, MO 65212, USA
    Int J Cancer 108:588-91. 2004
    Human kallikreins (hK) 2, 3, 6 and 10 are expressed in breast and prostate tissue. hK2 and hK3 (prostate-specific antigen, PSA) are used to screen for prostate cancer...
  60. ncbi The Salmonella SpiC protein targets the mammalian Hook3 protein function to alter cellular trafficking
    Yoram Shotland
    Department of Molecular Microbiology, Howard Hughes Medical Institute, Washington University School of Medicine, Campus Box 8230, 660 S Euclid Ave, St Louis, Missouri 63110 1093, USA
    Mol Microbiol 49:1565-76. 2003
    ..Here, we establish that SpiC targets the function of Hook3, a mammalian protein implicated in cellular trafficking...
  61. ncbi Overexpression of kallikrein 10 in epithelial ovarian carcinomas
    Hyun S Shvartsman
    Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Gynecol Oncol 90:44-50. 2003
    ..family of serine proteases which include 15 proteins, including the prostate-specific antigen (PSA), also known as hK3. We investigated whether KLK10 and its related protein, hK10, might serve as equally accurate markers for ovarian ..
  62. pmc Quantitative analysis of human kallikrein gene 14 expression in breast tumours indicates association with poor prognosis
    G M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Br J Cancer 87:1287-93. 2002
    ..This family harbours several genes aberrantly expressed in various cancers as well as established (PSA/hK3, hK2) and potential (hK6, hK10) cancer markers...
  63. ncbi Ethnic variation in kallikrein expression in nipple aspirate fluid
    Edward R Sauter
    Department of Surgery, Thomas Jefferson University, 1025 Walnut Street, Suite 605, Philadelphia, PA 19107, USA
    Int J Cancer 100:678-82. 2002
    ..antigen [PSA, also known as human kallikrein (hK) 3] is a marker of breast as well as prostate cancer, that hK2 and hK3 are highly homologous at the DNA and protein level and that the level of progesterone, which appears to upregulate ..
  64. ncbi Human tissue kallikreins: a family of new cancer biomarkers
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Chem 48:1198-205. 2002
    ..There is strong but circumstantial evidence linking kallikreins and cancer. Prostate-specific antigen (PSA; hK3) and, more recently, human glandular kallikrein (hK2) are widely used tumor markers for prostate cancer...
  65. ncbi Potential involvement of kallikrein hK2 in the hydrolysis of the human seminal vesicle proteins after ejaculation
    D Deperthes
    Laboratory of Hormonal Bioregulation, CHUL Research Center, Sainte Foy, Quebec, Canada
    J Androl 17:659-65. 1996
    ..patterns of hydrolysis of major seminal vesicle proteins, semenogelins and fibronectin were exposed to hK2 and to hK3 (prostate-specific antigen or PSA) and cleavage sequences were identified by N-terminal sequencing...

Research Grants10

  1. Human Kallikrein 4 (hK4): A New Prostatic Biomarker?
    Eleftherios Diamandis; Fiscal Year: 2003
    ..If successful, our research will contribute to the development of new prostatic biomarkers and possibly, to better diagnosis which may lead to better clinical outcomes and reduced healthcare costs. ..
  2. Epigenetic Effects of Resveratrol
    Edward Sauter; Fiscal Year: 2007
    ..As more and more Americans turn to nutraceuticals for a healthier lifestyle, studies like these are increasingly important in the fight against cancer. ..
  3. Breast Cancer Prediction Using Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ....
  4. KALLIKREINS AS DIAGNOSTIC MARKERS OF OVARIAN CARCINOMA
    Eleftherios Diamandis; Fiscal Year: 2007
    ..Relevance of this research to public health: By achieving early ovarian cancer diagnosis, it will be possible to reduce the burden of the disease by administration of effective treatment as early as possible. ..
  5. Protein Profiling in Nipple Aspirate Fluid
    Edward Sauter; Fiscal Year: 2007
    ..abstract_text> ..
  6. Altered Breast Methylation after Low/Hi Dose Isoflavones
    Edward Sauter; Fiscal Year: 2005
    ..abstract_text> ..
  7. The Effect of Black Cohosh Extract on the Human Breast
    Edward Sauter; Fiscal Year: 2004
    ..The findings should allow us to design a high quality R01 submission involving a larger, randomized study of longer duration which should provide some answers on the potential role of BCE in breast cancer. ..
  8. A New Biomarker for Ovarian Cancer Detection
    Eleftherios Diamandis; Fiscal Year: 2003
    ..In this grant proposal, we describe further studies, which will examine in greater detail, the ability of a test for the amount of this protein in blood to correctly diagnose the presence of ovarian cancer. ..