HOOK2

Summary

Gene Symbol: HOOK2
Description: hook microtubule tethering protein 2
Alias: HK2, protein Hook homolog 2, h-hook2, hHK2, hook homolog 2
Species: human
Products:     HOOK2

Top Publications

  1. Xu L, Sowa M, Chen J, Li X, Gygi S, Harper J. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol Biol Cell. 2008;19:5059-71 pubmed publisher
    ..the FHF complex, containing FTS, members of the microtubule-binding Hook family of coiled-coil proteins (Hook1, Hook2, and Hook3), and a previously uncharacterized 107-kDa protein, FTS and Hook Interacting Protein (FHIP)...
  2. Kr mer H, Phistry M. Genetic analysis of hook, a gene required for endocytic trafficking in drosophila. Genetics. 1999;151:675-84 pubmed
    ..The importance of all three domains for Hook function was confirmed by their conservation between two Drosophila and two human Hook proteins...
  3. Walenta J, Didier A, Liu X, Kramer H. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J Cell Biol. 2001;152:923-34 pubmed
    ..Because overexpression of Hook3 caused fragmentation of the Golgi complex, we propose that Hook3 participates in defining the architecture and localization of the mammalian Golgi complex. ..
  4. Szebenyi G, Hall B, Yu R, Hashim A, KRAMER H. Hook2 localizes to the centrosome, binds directly to centriolin/CEP110 and contributes to centrosomal function. Traffic. 2007;8:32-46 pubmed
    ..Here, we show that mammalian hook2, a previously uncharacterized member of the hook family, localizes to the centrosome through all phases of the ..
  5. Moynihan K, Pooley R, Miller P, Kaverina I, Bader D. Murine CENP-F regulates centrosomal microtubule nucleation and interacts with Hook2 at the centrosome. Mol Biol Cell. 2009;20:4790-803 pubmed publisher
    ..Using a yeast two-hybrid screen, we identify Hook2, a linker protein that is essential for regulation of the MT network at the centrosome, as a binding partner of ..
  6. Hwang S, Song J, Kim Y, Lim J, Kim M, Kim E, et al. Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice. Cell Death Dis. 2019;10:219 pubmed publisher
    ..In addition, we studied palmitate-induced lymphangiogenesis in human kidney-2 (HK2) cells and RAW264.7 monocytes/macrophages, which play a major role in lymphangiogenesis in the kidneys...
  7. Tyszka Czochara M, Bukowska Strakova K, Kocemba Pilarczyk K, Majka M. Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines. Nutrients. 2018;10: pubmed publisher
    ..as glucose transporters (GLUT1, GLUT3) and regulatory enzymes of glycolytic pathway Hexokinase 2 (HK2), 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4), Pyruvate Kinase (PKM) and ..
  8. Li Z, Hong Z, Peng Z, Zhao Y, Shao R. Acetylshikonin from Zicao ameliorates renal dysfunction and fibrosis in diabetic mice by inhibiting TGF-?1/Smad pathway. Hum Cell. 2018;31:199-209 pubmed publisher
    ..acetylshikonin markedly attenuated TGF-?1-induced the PAI-1, collagen III and IV, and Smad-2/3 phosphorylation in HK2 immortalized human proximal tubule epithelial cells...
  9. Massari F, Ciccarese C, Santoni M, Iacovelli R, Mazzucchelli R, Piva F, et al. Metabolic phenotype of bladder cancer. Cancer Treat Rev. 2016;45:46-57 pubmed publisher
    ..genes (SRC-3, glucose transporter type 1 [GLUT1], GLUT3, lactic dehydrogenase A [LDHA], LDHB, hexokinase 1 [HK1], HK2, pyruvate kinase type M [PKM], and hypoxia-inducible factor 1-alpha [HIF-1α]), resulting in an overproduction of ..

More Information

Publications136 found, 100 shown here

  1. Sen Z, Weida W, Jie M, Li S, Dongming Z, Xiaoguang C. Coumarin glycosides from Hydrangea paniculata slow down the progression of diabetic nephropathy by targeting Nrf2 anti-oxidation and smad2/3-mediated profibrosis. Phytomedicine. 2018;57:385-395 pubmed publisher
    ..2)-like 2 (Nrf2) and IL6 and western blot was performed to analyse the phosphorylation status of smad 2/3 in HK2 cells under TGFβ1 stimulation...
  2. Choe M, Brusgard J, Chumsri S, Bhandary L, Zhao X, Lu S, et al. The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells. J Cell Biochem. 2015;116:2210-26 pubmed publisher
    ..RUNX2 knockdown resulted in lower LDHA, HK2, and GLUT1 glycolytic gene expression, but upregulation of pyruvate dehydrogenase-A1 (PDHA1) mRNA and enzymatic ..
  3. Schutt A, Blesson C, Hsu J, Valdes C, Gibbons W, Jahoor F, et al. Preovulatory exposure to a protein-restricted diet disrupts amino acid kinetics and alters mitochondrial structure and function in the rat oocyte and is partially rescued by folic acid. Reprod Biol Endocrinol. 2019;17:12 pubmed publisher
    ..05) and Hk2 (p < 0...
  4. Xu X, Li D, Li X, Shi Q, Ju X. Mesenchymal stem cell conditioned medium alleviates oxidative stress injury induced by hydrogen peroxide via regulating miR143 and its target protein in hepatocytes. BMC Immunol. 2017;18:51 pubmed publisher
    ..cell conditioned medium (MSC-CM) and explore the roles of the beta-1 adrenergic receptor (ADRB1) and hexokinase 2 (HK2) in this process...
  5. Harfmann B, Schroder E, Kachman M, Hodge B, Zhang X, Esser K. Muscle-specific loss of Bmal1 leads to disrupted tissue glucose metabolism and systemic glucose homeostasis. Skelet Muscle. 2016;6:12 pubmed publisher
    ..We also found that both mRNA expression and activity of two key rate-limiting enzymes of glycolysis, hexokinase 2 (Hk2) and phosphofructokinase 1 (Pfk1), were significantly reduced in the iMSBmal1 (-/-) muscle...
  6. Xiao W, Sarsour E, Wagner B, Doskey C, Buettner G, Domann F, et al. Succinate dehydrogenase activity regulates PCB3-quinone-induced metabolic oxidative stress and toxicity in HaCaT human keratinocytes. Arch Toxicol. 2016;90:319-32 pubmed publisher
    ..Results from a q-RT-PCR assay showed significant increases in the mRNA levels of hexokinase 2 (hk2), pyruvate kinase M2 (pkm2) and glucose-6-phosphate dehydrogenase (g6pd), and decreases in the mRNA levels of ..
  7. Shahzad M, Small D, Morais C, Wojcikowski K, Shabbir A, Gobe G. Protection against oxidative stress-induced apoptosis in kidney epithelium by Angelica and Astragalus. J Ethnopharmacol. 2016;179:412-9 pubmed publisher
    ..membranaceus and A. sinensis were prepared by a three-solvent sequential process. HK2 human kidney proximal tubular epithelial cells were treated with H2O2 alone (0...
  8. Rodriguez S, Rudloff S, Koenig K, Karthik S, Hoogewijs D, Huynh Do U. Bidirectional signalling between EphA2 and ephrinA1 increases tubular cell attachment, laminin secretion and modulates erythropoietin expression after renal hypoxic injury. Pflugers Arch. 2016;468:1433-48 pubmed publisher
    ..Stimulation of EphA2 forward signalling in the proximal tubular cell line HK2 increased cell attachment and laminin secretion at the baso-lateral side...
  9. Broecker Preuss M, Becher Boveleth N, Bockisch A, Duhrsen U, Muller S. Regulation of glucose uptake in lymphoma cell lines by c-MYC- and PI3K-dependent signaling pathways and impact of glycolytic pathways on cell viability. J Transl Med. 2017;15:158 pubmed publisher
    ..Expression of mRNAs of the glucose transporter 1 (GLUT1), hexokinase 2 (HK2), glucose-6-phosphatase (G6Pase) and lactate dehydrogenase A (LDHA) and of the glucose metabolism-regulating micro ..
  10. de Andrade Barreto E, de Souza Santos P, Bergmann A, de Oliveira I, Wernersbach Pinto L, Blanco T, et al. Alterations in glucose metabolism proteins responsible for the Warburg effect in esophageal squamous cell carcinoma. Exp Mol Pathol. 2016;101:66-73 pubmed publisher
    ..We performed immunohistochemistry to determine HIF-1α, GLUT-1, PKM1, PKM2, HK2 and Ki67-expression in ESCC patients and controls...
  11. Zhou H, Hu S, Jin Q, Shi C, Zhang Y, Zhu P, et al. Mff-Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS-Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation-Involved mPTP Opening. J Am Heart Assoc. 2017;6: pubmed publisher
  12. Cheng H, Chang W, Hu Y, Hsieh B, Huang T, Chong I, et al. Arecoline Increases Glycolysis and Modulates pH Regulator Expression in HA22T/VGH Hepatoma Cells, Leading to Increase of Intracellular Ca2+, Reactive Oxygen Species, and Anoikis. J Cancer. 2017;8:3173-3182 pubmed publisher
    ..through induction of glycolytic genes, including glucose transporter 3 (Glut3), hexokinase 1 (HK1), hexokinase 2 (HK2), and pyruvate kinase (PK)...
  13. Nam H, Chandrashekar D, Kundu A, Shelar S, Kho E, Sonpavde G, et al. Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis. Mol Cancer Res. 2019;17:84-96 pubmed publisher
    ..IMPLICATIONS: Collectively, these data provide significant insight into the biology of aggressive RCC and demonstrate a novel role for DNA methylation in the promotion of HIF signaling and invasive phenotypes in renal cancer. ..
  14. Amrutkar M, Cansby E, Chursa U, Nuñez Durán E, Chanclón B, Ståhlman M, et al. Genetic Disruption of Protein Kinase STK25 Ameliorates Metabolic Defects in a Diet-Induced Type 2 Diabetes Model. Diabetes. 2015;64:2791-804 pubmed publisher
    ..controlling the muscle oxidative capacity (Cpt1, Acox1, Cs, Cycs, Ucp3) and glucose metabolism (Glut1, Glut4, Hk2) was increased...
  15. Wang Q, Gao H, Liang Y, Zhang J, Wang J, Qiu J. Cofilin1 is involved in hypertension-induced renal damage via the regulation of NF-κB in renal tubular epithelial cells. J Transl Med. 2015;13:323 pubmed publisher
    ..phosphorylation of cofilin1, the formation of actin stress fibres and nuclear translocation of NF-κB p65 in the HK2 cells...
  16. Nahon J, Hoekstra M, van Harmelen V, Rensen P, Willems van Dijk K, Kooijman S, et al. Proteoglycan 4 deficiency protects against glucose intolerance and fatty liver disease in diet-induced obese mice. Biochim Biophys Acta Mol Basis Dis. 2018;1865:494-501 pubmed publisher
    ..01), Pfkm (-21%; p < 0.05) and Hk2 (-39%; p < 0.001)...
  17. Gu Z, Xia J, Xu H, Frech I, Tricot G, Zhan F. NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase. J Hematol Oncol. 2017;10:17 pubmed publisher
    ..Knockdown of NEK2 decreases the ratio of PKM2/PKM1 and also other aerobic glycolysis genes including GLUT4, HK2, ENO1, LDHA, and MCT4...
  18. Soler Torronteras R, Lara Chica M, Garcia V, Calzado M, Munoz E. Hypoximimetic activity of N-acyl-dopamines. N-arachidonoyl-dopamine stabilizes HIF-1? protein through a SIAH2-dependent pathway. Biochim Biophys Acta. 2014;1843:2730-43 pubmed publisher
    ..as erythropoietin (EPO), vascular endothelial growth factor A (VEGFA), heme oxygenase 1 (HMOX-1), hexokinase 2 (HK2) and Bcl-2/E1B-nineteen kiloDalton interacting protein (BNIP3) in primary astrocytes...
  19. Zheng L, Zhu X, Yang K, Zhu M, Farooqi A, Kang D, et al. PBN11-8, a Cytotoxic Polypeptide Purified from Marine Bacillus, Suppresses Invasion and Migration of Human Hepatocellular Carcinoma Cells by Targeting Focal Adhesion Kinase Pathways. Polymers (Basel). 2018;10: pubmed publisher
    ..Moreover, the polypeptide displayed weak cytotoxicity towards normal cell line renal tubular epithelial cell line HK2 and human normal liver cell line L02 cells...
  20. Wu H, Huang T, Ying L, Han C, Li D, Xu Y, et al. MiR-155 is Involved in Renal Ischemia-Reperfusion Injury via Direct Targeting of FoxO3a and Regulating Renal Tubular Cell Pyroptosis. Cell Physiol Biochem. 2016;40:1692-1705 pubmed publisher
    ..Similarly, hypoxia-reoxygenation injury (HRI) also induced pyroptosis in HK2 cells...
  21. Cho J, Kim G, Mansfield B, Chou J. Hepatic glucose-6-phosphatase-α deficiency leads to metabolic reprogramming in glycogen storage disease type Ia. Biochem Biophys Res Commun. 2018;498:925-931 pubmed publisher
    ..Moreover, the HCA/HCC lesions in L-G6pc-/- mice exhibit elevated levels of hexokinase 2 (HK2) and the M2 isoform of pyruvate kinase (PKM2) which play an important role in aerobic glycolysis and cancer cell ..
  22. Pavo N, Lukovic D, Zlabinger K, Lorant D, Goliasch G, Winkler J, et al. Intrinsic remote conditioning of the myocardium as a comprehensive cardiac response to ischemia and reperfusion. Oncotarget. 2017;8:67227-67240 pubmed publisher
    ..genes of interest (HIF-1?; caspase-3, transcription factor GATA4; myocyte enhancer factor 2C /MEF2c/; hexokinase 2 /HK2/; clusterin /CLU/ and excision repair cross-complementation group 4 /ERCC4/) were measured by qPCR...
  23. Ding T, Wang S, Zhang X, Zai W, Fan J, Chen W, et al. Kidney protection effects of dihydroquercetin on diabetic nephropathy through suppressing ROS and NLRP3 inflammasome. Phytomedicine. 2018;41:45-53 pubmed publisher
    ..by high-fat diet/streptozotocin in vivo and the underlying mechanisms of DHQ on renal cells including HBZY-1 and HK2 exposed to high glucose in vitro...
  24. Xu X, Li J, Sun X, Guo Y, Chu D, Wei L, et al. Tumor suppressor NDRG2 inhibits glycolysis and glutaminolysis in colorectal cancer cells by repressing c-Myc expression. Oncotarget. 2015;6:26161-76 pubmed publisher
    ..and the catalytic enzymes involved in glycolysis revealed that glucose transporter 1 (GLUT1), hexokinase 2 (HK2), pyruvate kinase M2 isoform (PKM2) and lactate dehydrogenase A (LDHA) was significantly suppressed by NDRG2...
  25. Sato Y, Sato Y, Obeng K, Yoshizawa F. Acute oral administration of L-leucine upregulates slow-fiber- and mitochondria-related genes in skeletal muscle of rats. Nutr Res. 2018;57:36-44 pubmed publisher
    ..Although the gene expression of representative glycolytic enzymes (Hk2 and Eno3) was not altered, L-leucine administration (135 mg/100 g body weight) upregulated the expression of slow-..
  26. Wang L, Wang J, Xiong H, Wu F, Lan T, Zhang Y, et al. Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer. EBioMedicine. 2016;7:50-61 pubmed publisher
    ..In contrast, mechanism-driven co-targeting hexokinase 2 (HK2)-mediated Warburg effect with 2-deoxyglucose (2-DG) and ULK1-dependent autophagy with chloroquine (CQ) selectively ..
  27. Li Y, Lu B, Sheng L, Zhu Z, Sun H, Zhou Y, et al. Hexokinase 2-dependent Hyperglycolysis Driving Microglial Activation Contributes to Ischemic Brain Injury. J Neurochem. 2017;: pubmed publisher
    ..and primary microglial cultures, we found hyperglycolysis and induction of the key glycolytic enzyme hexokinase 2 (HK2) were essential for microglia-mediated neuroinflammation under hypoxia...
  28. Tian M, Xie Y, Meng Y, Ma W, Tong Z, Yang X, et al. Resveratrol protects cardiomyocytes against anoxia/reoxygenation via dephosphorylation of VDAC1 by Akt-GSK3 β pathway. Eur J Pharmacol. 2019;843:80-87 pubmed publisher
    ..Moreover, we found phosphorylated VDAC1 showed increased affinity to Bax, whereas interaction with hexokinase 2 (HK2) was reduced...
  29. Suh S, Kim Y, Goh T, Jeong D, Lee C, Jang J, et al. mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas. Yonsei Med J. 2018;59:746-753 pubmed publisher
    ..In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC without BRAF mutations...
  30. Miller P, Shuler M. Design and demonstration of a pumpless 14 compartment microphysiological system. Biotechnol Bioeng. 2016;113:2213-27 pubmed publisher
    ..organs (barrier lines-A549 [lung] and Caco2 [GI]) (nonbarrier lines-HepG2 C3A [liver], Meg01 [bone marrow], and HK2 [kidney])...
  31. Zhang W, Qiu M, WANG X, Sun K, Zheng Y, Jing Z. Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension. Respir Res. 2014;15:119 pubmed publisher
    ..Hexokinase 2(HK2), pyruvate dehydrogenase complex α1 (PDHα1), and LDHA mRNA expression showed no changes in the right ..
  32. Wang Y, Ma J, Yan X, Chen X, Si L, Liu Y, et al. Isoliquiritigenin Inhibits Proliferation and Induces Apoptosis via Alleviating Hypoxia and Reducing Glycolysis in Mouse Melanoma B16F10 Cells. Recent Pat Anticancer Drug Discov. 2016;11:215-27 pubmed
    ..a series of glycolysis-relevant enzymes expression, including glucose transporters 1/4 (GLUT 1/4), hexokinase 2 (HK2), pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA)...
  33. Chen R, Li J, Zhou X, Liu J, Huang G. Fructose-1,6-Bisphosphatase 1 Reduces 18F FDG Uptake in Hepatocellular Carcinoma. Radiology. 2017;284:844-853 pubmed publisher
    ..standardized uptake (SUVmax) and expression of FBP1, glucose transporter 1 (GLUT1), and hexokinase 2 (HK2) was analyzed with immunohistochemical analysis...
  34. Bao F, Yang K, Wu C, Gao S, Wang P, Chen L, et al. New natural inhibitors of hexokinase 2 (HK2): Steroids from Ganoderma sinense. Fitoterapia. 2018;125:123-129 pubmed publisher
    Hexokinase 2 (HK2), a rate-limiting enzyme in the first step of glycolysis pathway, expresses at high level in cancer cells compared with normal cells...
  35. Kim H, Jang H, Kim T, Kang B, Lee S, Jeon Y, et al. Core Pluripotency Factors Directly Regulate Metabolism in Embryonic Stem Cell to Maintain Pluripotency. Stem Cells. 2015;33:2699-711 pubmed publisher
    ..Specifically, Oct4 directly governs Hk2 and Pkm2, which are important glycolytic enzymes that determine the rate of glycolytic flux...
  36. Menendez M, Teygong C, Wade K, Florimond C, Blader I. siRNA Screening Identifies the Host Hexokinase 2 (HK2) Gene as an Important Hypoxia-Inducible Transcription Factor 1 (HIF-1) Target Gene in Toxoplasma gondii-Infected Cells. MBio. 2015;6:e00462 pubmed publisher
    ..Among the genes identified by this screen, we focused on the hexokinase 2 (HK2) gene because its expression is regulated by hypoxia-inducible transcription factor 1 (HIF-1), which is important ..
  37. Kretschmar C, Oyarzun C, Villablanca C, Jaramillo C, Alarcón S, Perez G, et al. Reduced Adenosine Uptake and Its Contribution to Signaling that Mediates Profibrotic Activation in Renal Tubular Epithelial Cells: Implication in Diabetic Nephropathy. PLoS ONE. 2016;11:e0147430 pubmed publisher
    ..At the cellular level, exposure of HK2 cells to high glucose, TGF-β and the general adenosine receptor agonist NECA, induced the expression of ..
  38. Zhao Z, Liao G, Zhou Q, Lv D, Holthfer H, Zou H. Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway. Oxid Med Cell Longev. 2016;2016:9825623 pubmed publisher
    ..the antioxidant effects of sulforaphane (SFN) in a rat model of CIN and a cell model of oxidative stress in HK2 cells. Methods...
  39. Hoppe Seyler K, Honegger A, Bossler F, Sponagel J, Bulkescher J, Lohrey C, et al. Viral E6/E7 oncogene and cellular hexokinase 2 expression in HPV-positive cancer cell lines. Oncotarget. 2017;8:106342-106351 pubmed publisher
    ..in cancer cells is often linked to an increased expression of the rate-limiting glycolytic enzyme Hexokinase 2 (HK2)...
  40. Krasnov G, Dmitriev A, Sadtritdinova A, Fedorova M, Snezhkina A, Melnikova N, et al. [Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods]. Biofizika. 2015;60:1050-6 pubmed
    ..The glycolysis activation can be caused by overexpression of hexokinases, primarily HK1 and HK2. Colorectal cancer, which takes the third place in the cancer morbidity and mortality rates worldwide, is believed ..
  41. Zhao K, Murray E, Murray S. HK2 Proximal Tubule Epithelial Cells Synthesize and Secrete Plasma Proteins Predominantly Through the Apical Surface. J Cell Biochem. 2017;118:924-933 pubmed publisher
    ..We now demonstrate that even at a resting state, a PTEC cell line, HK2 expresses mRNAs for and synthesizes and secretes plasma proteins in a complex with complement C3, an α2
  42. de Brito Alves J, Toscano A, da Costa Silva J, Vidal H, Leandro C, Pirola L. Transcriptional response of skeletal muscle to a low protein perinatal diet in rat offspring at different ages: The role of key enzymes of glucose-fatty acid oxidation. J Nutr Biochem. 2017;41:117-123 pubmed publisher
    ..This study evaluated gene and protein expression of key-enzymes of glycolytic pathway (HK2, PFK, PDK4 and CS), and fatty acid oxidation (CPT1 and β-HAD) of two different types of skeletal muscle [soleus ..
  43. Conde E, Giménez Moyano S, Martín Gómez L, Rodriguez M, Ramos M, Aguado Fraile E, et al. HIF-1α induction during reperfusion avoids maladaptive repair after renal ischemia/reperfusion involving miR127-3p. Sci Rep. 2017;7:41099 pubmed publisher
    ..In vitro, HIF-1α knockdown in HK2 cells subjected to hypoxia/reoxygenation (H/R) promote cell entry into S phase, correlating with in vivo data...
  44. Zhao Y, Yin Z, Li H, Fan J, Yang S, Chen C, et al. MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice. Aging Cell. 2017;16:387-400 pubmed publisher
    ..this study, loss of miR-30c accompanied with increased EMT was observed in renal tubules of db/db mice and cultured HK2 cells exposed to high glucose...
  45. Xu H, Sun F, Li X, Sun L. Down-regulation of miR-23a inhibits high glucose-induced EMT and renal fibrogenesis by up-regulation of SnoN. Hum Cell. 2018;31:22-32 pubmed publisher
    ..Our purpose is to study the effects of miR-23a on high glucose (HG)-induced EMT process and ECM deposition in HK2 cells. We found that miR-23a was up-regulated in renal tissues of diabetic patients and HG-induced HK2 cells...
  46. Huang X, Liu M, Sun H, Wang F, Xie X, Chen X, et al. HK2 is a radiation resistant and independent negative prognostic factor for patients with locally advanced cervical squamous cell carcinoma. Int J Clin Exp Pathol. 2015;8:4054-63 pubmed
    The mechanism by which overexpression of hexokinase 2 (HK2) indicates locally advanced cervical squamous cell carcinoma (LACSCC) with radio-resistance is still unknown despite being an independent biomarker of poor prognosis...
  47. Zhuo B, Li Y, Li Z, Qin H, Sun Q, Zhang F, et al. PI3K/Akt signaling mediated Hexokinase-2 expression inhibits cell apoptosis and promotes tumor growth in pediatric osteosarcoma. Biochem Biophys Res Commun. 2015;464:401-6 pubmed publisher
    ..In this study, we showed that elevated Hexokinase-2 (HK2) expression, which catalyzes the first essential step of glucose metabolism by conversion of glucose into glucose-6-..
  48. Siamantouras E, Hills C, Squires P, Liu K. Quantifying cellular mechanics and adhesion in renal tubular injury using single cell force spectroscopy. Nanomedicine. 2016;12:1013-1021 pubmed publisher
    ..changes in cellular stiffness and cell adhesion in TGF-β1 treated kidney cells of the human proximal tubule (HK2)...
  49. Terryn S, Tanaka K, Lengelé J, Olinger E, Dubois Laforgue D, Garbay S, et al. Tubular proteinuria in patients with HNF1? mutations: HNF1? drives endocytosis in the proximal tubule. Kidney Int. 2016;89:1075-1089 pubmed publisher
    ..Transfection of human proximal tubule HK2 cells with HNF1? was able to upregulate megalin and cubilin expression and to increase endocytosis of albumin...
  50. Wang J, Duan Z, Nugent Z, Zou J, Borowsky A, Zhang Y, et al. Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes. Cancer Lett. 2016;378:69-79 pubmed publisher
    ..Its overexpression coordinately up-regulated hexokinase 2 (HK2) and glucose-6-phosphate dehydrogenase (G6PD), two key enzymes of glycolysis and the pentose phosphate pathway (PPP)..
  51. Li F, Li L, Hao J, Liu S, Duan H. Src Homology 2 Domain-Containing Inositol 5'-Phosphatase Ameliorates High Glucose-Induced Extracellular Matrix Deposition via the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway in Renal Tubular Epithelial Cells. J Cell Biochem. 2017;118:2271-2284 pubmed publisher
    ..effect of SHIP on ECM deposition in diabetic mice and high glucose-stimulated human renal tubular epithelial cells (HK2 cells)...
  52. Ju H, Zhan G, Huang A, Sun Y, Wen S, Yang J, et al. ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition. Leukemia. 2017;31:2143-2150 pubmed publisher
    ..causes a significant increase in aerobic glycolysis through AKT-mediated upregulation of mitochondrial hexokinase (HK2), and renders the leukemia cells highly dependent on glycolysis and sensitive to pharmacological inhibition of ..
  53. Zhang X, Liu L, Liu J, Cheng Z, Wang Z, Shi C, et al. Endothelial cells co-cultured with renal carcinoma cells significantly reduce RECK expression under chemical hypoxia. Cell Biol Int. 2017;41:922-927 pubmed publisher
    ..Effects of different environments on RECK expressions in 786-0, HK2, or HMEC-1 cells were determined by Western blot...
  54. Timmermand O, Ulmert D, Evans Axelsson S, Pettersson K, Bjartell A, Lilja H, et al. Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a (111)In-radiolabelled monoclonal antibody, 11B6. EJNMMI Res. 2014;4:51 pubmed publisher
    ..Human kallikrein-related peptidase 2 (hK2) is abundantly expressed in malignant prostatic tissue, and its gene, KLK2, is regulated by the androgen receptor...
  55. Zhou P, Chen W, Li X. MicroRNA-143 acts as a tumor suppressor by targeting hexokinase 2 in human prostate cancer. Am J Cancer Res. 2015;5:2056-63 pubmed
    ..Furthermore, we identified hexokinase 2 (HK2), a metabolic enzyme that executes the first step of aerobic glycolysis, as a target of miR-143 in prostate cancer...
  56. Tiazhka O, Minchenko D, Davydov V, Moliavko O, Budreiko O, Kulieshova D, et al. [EXPRESSION OF GENES, WHICH CONTROL GLUCOSE METABOLISM, IN BLOOD CELLS OF THE OBESE BOYS WITH INSULIN RESISTANCE]. Lik Sprava. 2015;:66-71 pubmed
    ..It was shown that the expression level of PFKFB3 gene is increased, PFKFB1 and INSIG2--is decreased, but HK2 gene--significantly does not change in the blood cells of obese boys with normal insulin sensitivity as compared to ..
  57. Seifi Najmi M, Hajivalili M, Safaralizadeh R, Sadreddini S, Esmaeili S, Razavi R, et al. SiRNA/DOX lodeded chitosan based nanoparticles: Development, Characterization and in vitro evaluation on A549 lung cancer cell line. Cell Mol Biol (Noisy-le-grand). 2016;62:87-94 pubmed
    High-mobility group AT-hook2 (HMGA2), involved in epithelial mesenchymal transition (EMT) process, has a pivotal role in lung cancer metastasis...
  58. Gunnink L, Busscher B, Wodarek J, Rosette K, Strohbehn L, Looyenga B, et al. Caffeine inhibition of GLUT1 is dependent on the activation state of the transporter. Biochimie. 2017;137:99-105 pubmed publisher
    ..Two epithelial cell lines, HCLE and HK2, have both higher concentrations of GLUT1 and increased basal 2DG uptake (3-4 fold) compared to L929 cells, and ..
  59. Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, et al. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia. Physiol Rep. 2017;5: pubmed publisher
    ..Immortalized tubular cell lines (HK2; human kidney-2) and primary cultured cells (RPTEC; renal proximal tubular cell lines) were exposed to 1% hypoxia ..
  60. Pham L, Ramírez S, Gottwein J, Fahnøe U, Li Y, Pedersen J, et al. HCV Genotype 6a Escape From and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models. Gastroenterology. 2018;154:2194-2208.e12 pubmed publisher
    ..The consensus sequences of strains HK2 (MG717925) and HK6a (MG717928), originating from serum of patients with chronic HCV infection, were determined by ..
  61. Lee S, Hosokawa K, Kim S, Jeong O, Lilja H, Laurell T, et al. A Highly Sensitive Porous Silicon (P-Si)-Based Human Kallikrein 2 (hK2) Immunoassay Platform toward Accurate Diagnosis of Prostate Cancer. Sensors (Basel). 2015;15:11972-87 pubmed publisher
    Levels of total human kallikrein 2 (hK2), a protein involved the pathology of prostate cancer (PCa), could be used as a biomarker to aid in the diagnosis of this disease...
  62. Chen Y, Chou C, Sun C. Impairment of the Cellular Distribution and Stability of the Erythropoietin Receptor Through the Direct Targeting of Aristolochic Acid. Toxicol Sci. 2015;147:246-54 pubmed publisher
    ..receptor (EPOR) in AA-induced anemia in both AA nephropathy zebrafish and cultured human renal tubular cells (HK2)...
  63. Spratt D, Evans M, Davis B, Doran M, Lee M, Shah N, et al. Androgen Receptor Upregulation Mediates Radioresistance after Ionizing Radiation. Cancer Res. 2015;75:4688-96 pubmed publisher
    ..We also provide evidence of AR pathway upregulation, measured by a rise in serum levels of AR-regulated hK2 protein, in nearly 20% of patients after radiotherapy...
  64. Shen C, Wei W, Qiu Z, Song H, Zhang X, Sun Z, et al. Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo. J Mol Endocrinol. 2017;58:15-23 pubmed
    ..reduced after metformin treatment in a dose-dependent manner, corresponding to the reduced expression level of HK2 and GLUT1 in vitro Xenograft model of PTC using BCPAP cells was achieved successfully...
  65. Hsieh W, Ramadesikan S, FEKETE D, Aguilar R. Kidney-differentiated cells derived from Lowe Syndrome patient's iPSCs show ciliogenesis defects and Six2 retention at the Golgi complex. PLoS ONE. 2018;13:e0192635 pubmed publisher
    ..of differentiated cells from different iPSC colonies and by the use of the human proximal tubule kidney cell line HK2. Indeed, OCRL1 KO led to both ciliogenesis defects and Six2 retention in the Golgi complex...
  66. Li Z, Zheng W, Li H, Li C, Gong Z. Synergistic Induction of Potential Warburg Effect in Zebrafish Hepatocellular Carcinoma by Co-Transgenic Expression of Myc and xmrk Oncogenes. PLoS ONE. 2015;10:e0132319 pubmed publisher
    ..Critical glycolytic genes including hk2, pkm and ldha were significantly up-regulated in Myc/xmrk tumors but not in either single oncogene-induced tumors, ..
  67. Botzer L, Maman S, Sagi Assif O, Meshel T, Nevo I, Yron I, et al. Hexokinase 2 is a determinant of neuroblastoma metastasis. Br J Cancer. 2016;114:759-66 pubmed publisher
    ..expression profiles of tumours from stage 1 and 4 neuroblastoma patients, we previously characterised hexokinase 2 (HK2) as a gene whose expression was upregulated in both metastatic neuroblastoma variants and tumours from stage 4 ..
  68. Chen T, Zhou Q, Tang H, Bozkanat M, Yuan J, Raj J, et al. miR-17/20 Controls Prolyl Hydroxylase 2 (PHD2)/Hypoxia-Inducible Factor 1 (HIF1) to Regulate Pulmonary Artery Smooth Muscle Cell Proliferation. J Am Heart Assoc. 2016;5: pubmed
    ..miR-17~92 inhibitors suppress hypoxia-induced levels of HIF1?, VEGF, Glut1, HK2, and PDK1 but not HIF2? in vitro in PASMC...
  69. Wang W, Liu Z, Zhao L, Sun J, He Q, Yan W, et al. Hexokinase 2 enhances the metastatic potential of tongue squamous cell carcinoma via the SOD2-H2O2 pathway. Oncotarget. 2017;8:3344-3354 pubmed publisher
    The glycolytic enzyme hexokinase (HK2), which is aberrantly expressed in various types of tumours, is associated with metastasis...
  70. Ye X, Anjum K, Song T, Wang W, Liang Y, Chen M, et al. Antiproliferative cyclodepsipeptides from the marine actinomycete Streptomyces sp. P11-23B downregulating the tumor metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis. Phytochemistry. 2017;135:151-159 pubmed publisher
    ..Further investigation demonstrated that streptodepsipeptide P11A downregulated expression of HK2, PFKFB3, PKM2, GLS, and FASN, important tumor metabolic enzymes...
  71. Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, et al. Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer. Acta Biochim Biophys Sin (Shanghai). 2017;49:119-127 pubmed publisher
    ..Further analysis indicated that HIF1?-targeted glycolytic genes, including GLUT1, HK2, and LDHA, are all prognostic factors and positively correlated with HMGB2 expression...
  72. Saleem M, Pokkunuri I, Asghar M. Superoxide increases angiotensin II AT1 receptor function in human kidney-2 cells. FEBS Open Bio. 2016;6:1273-1284 pubmed publisher
    ..and the specific role of Sp3 transcription factor, if any, in the regulation of AT1R in human kidney cells (HK2 cells)...
  73. Zhou H, Zhang Y, Hu S, Shi C, Zhu P, Ma Q, et al. Melatonin protects cardiac microvasculature against ischemia/reperfusion injury via suppression of mitochondrial fission-VDAC1-HK2-mPTP-mitophagy axis. J Pineal Res. 2017;63: pubmed publisher
    ..fission, which subsequently induced voltage-dependent anion channel 1 (VDAC1) oligomerization, hexokinase 2 (HK2) liberation, mitochondrial permeability transition pore (mPTP) opening, PINK1/Parkin upregulation, and ultimately ..
  74. Karimi L, Mansoori B, Shanebandi D, Mohammadi A, Aghapour M, Baradaran B. Function of microRNA-143 in different signal pathways in cancer: New insights into cancer therapy. Biomed Pharmacother. 2017;91:121-131 pubmed publisher
    ..MiRNA-143 is involved in the pathogenesis of cancers by directly targeting several mRNAs such as Bcl-2, KRAS, HK2, DNMT3A, TP53 and MMP-13...
  75. Yang P, Xiao Y, Luo X, Zhao Y, Zhao L, Wang Y, et al. Inflammatory stress promotes the development of obesity-related chronic kidney disease via CD36 in mice. J Lipid Res. 2017;58:1417-1427 pubmed publisher
    ..In both human mesangial cells (HMCs) and human kidney 2 (HK2) cells, inflammatory stress increased the efficiency of CD36 protein incorporation into membrane lipid rafts, ..
  76. Vickers A, Vertosick E, Sjoberg D, Hamdy F, Neal D, Bjartell A, et al. Value of Intact Prostate Specific Antigen and Human Kallikrein 2 in the 4 Kallikrein Predictive Model: An Individual Patient Data Meta-Analysis. J Urol. 2018;199:1470-1474 pubmed publisher
    ..The panel includes 2 novel markers, namely intact prostate specific antigen and hK2. It has been questioned whether these 2 additional markers add discrimination to the clinical predictors of patient ..
  77. He W, Fang N, Wang R, Wu Y, Zeng G, Guan C, et al. Fine Mapping of a New Race-Specific Blast Resistance Gene, Pi-hk2, in Japonica Heikezijing from Taihu Region of China. Phytopathology. 2017;107:84-91 pubmed
    ..10 and phenotypic variance of 46.19% and might be a major QTL, named Pi-hk2. The line RIL84 with Pi-hk2 derived from a cross between Heikezijing and Suyunuo was selected as Pi-hk2 gene donor ..
  78. Zheng X, Han H, Liu G, Ma Y, Pan R, Sang L, et al. LncRNA wires up Hippo and Hedgehog signaling to reprogramme glucose metabolism. EMBO J. 2017;36:3325-3335 pubmed publisher
    ..BCAR4, which subsequently coordinates the Hedgehog signaling to enhance the transcription of glycolysis activators HK2 and PFKFB3...
  79. Contreras Galindo R, Dube D, Fujinaga K, Kaplan M, Markovitz D. Susceptibility of Human Endogenous Retrovirus Type K to Reverse Transcriptase Inhibitors. J Virol. 2017;91: pubmed publisher
    Human endogenous retroviruses (HERVs) make up 8% of the human genome. The HERV type K (HERV-K) HML-2 (HK2) family contains proviruses that are the most recent entrants into the human germ line and are transcriptionally active...
  80. Marampon F, Antinozzi C, Corinaldesi C, Vannelli G, Sarchielli E, Migliaccio S, et al. The phosphodiesterase 5 inhibitor tadalafil regulates lipidic homeostasis in human skeletal muscle cell metabolism. Endocrine. 2018;59:602-613 pubmed publisher
    ..to cellular energy control, glycolitic activity or microtubule formation/vesicle transport, as GLUT4, PPARγ, HK2, IRS-1, KIF1C, and KIFAP3; (ii) GLUT4, Flotillin-1, and Caveolin-1 localization, all proteins involved in energy-..
  81. Vallée A, Lecarpentier Y, Guillevin R, Vallée J. Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration. J Mol Neurosci. 2017;62:368-379 pubmed publisher
    ..Increased WNT/beta-catenin pathway involves hexokinase 2 (HK2) and pyruvate kinase M2 (PKM2)...
  82. Guo N, Zhang J, Wu J, Xu Y. Isoflurane promotes glucose metabolism through up-regulation of miR-21 and suppresses mitochondrial oxidative phosphorylation in ovarian cancer cells. Biosci Rep. 2017;37: pubmed publisher
    ..The glycolysis enzymes, HK2, PKM2, and LDHA were up-regulated by isoflurane...
  83. Ruben J, García Romo G, Breman E, van der Kooij S, Redeker A, Arens R, et al. Human plasmacytoid dendritic cells acquire phagocytic capacity by TLR9 ligation in the presence of soluble factors produced by renal epithelial cells. Kidney Int. 2018;93:355-364 pubmed publisher
    ..Maturation and interferon alpha production by pDCs was enhanced when cells were activated in the presence of viable HK2 renal epithelial cells...
  84. Zhang X, Zhang M, Cong Q, Zhang M, Zhang M, Lu Y, et al. Hexokinase 2 confers resistance to cisplatin in ovarian cancer cells by enhancing cisplatin-induced autophagy. Int J Biochem Cell Biol. 2018;95:9-16 pubmed publisher
    ..Hexokinase 2 (HK2) phosphorylates glucose to generate glucose-6-phosphate, the rate-limiting step in glycolysis...
  85. Gupta P, Sheikh T, Sen E. SIRT6 regulated nucleosomal occupancy affects Hexokinase 2 expression. Exp Cell Res. 2017;357:98-106 pubmed publisher
    ..association between inflammation and dysregulated metabolism in glioblastoma, the effect of IL-1? on Hexokinase 2 (HK2) expression was investigated. IL-1? induced HK2 expression was accompanied by heightened SIRT6 and MZF1 levels...
  86. Singh A, Sen E. Reciprocal role of SIRT6 and Hexokinase 2 in the regulation of autophagy driven monocyte differentiation. Exp Cell Res. 2017;360:365-374 pubmed publisher
    ..An increase in PPAR?, HK2 and SIRT6 expression was observed upon PMA induced monocyte differentiation...
  87. Kim I, Kwon M, Jung J, Nam T. Protein extracted from Porphyra yezoensis prevents cisplatin-induced nephrotoxicity by downregulating the MAPK and NF-?B pathways. Int J Mol Med. 2018;41:511-520 pubmed publisher
    ..The present study investigated the effects of PYP on cisplatin?induced nephrotoxicity in the HK2 human proximal tubular epithelial cell line...
  88. Luo R, Kakizoe Y, Wang F, Fan X, Hu S, Yang T, et al. Deficiency of mPGES-1 exacerbates renal fibrosis and inflammation in mice with unilateral ureteral obstruction. Am J Physiol Renal Physiol. 2017;312:F121-F133 pubmed publisher
    ..CAY10598 prevented the activation of NLRP3 inflammasomes induced by angiotensin II in human proximal tubule cells (HK2)...
  89. Zhu W, Huang Y, Pan Q, Xiang P, Xie N, Yu H. MicroRNA-98 Suppress Warburg Effect by Targeting HK2 in Colon Cancer Cells. Dig Dis Sci. 2017;62:660-668 pubmed publisher
    ..miR-98 inhibited glycolysis by directly targeting hexokinase 2, or HK2, illustrating a novel pathway to mediate Warburg effect of cancer cells...
  90. Jin J, Tao J, Gu X, Yu Z, Wang R, Zuo G, et al. P16 INK4a Deletion Ameliorated Renal Tubulointerstitial Injury in a Stress-induced Premature Senescence Model of Bmi-1 Deficiency. Sci Rep. 2017;7:7502 pubmed publisher
    ..epithelial-to-mesenchymal transition (EMT) was examined in Bmi-1-knockdown human renal proximal tubular epithelial (HK2) cells, which were treated with concentrated conditioned medium (CM) from the fifth-passage renal interstitial ..
  91. Kou B, Liu W, Tang X, Kou Q. HMGA2 facilitates epithelial-mesenchymal transition in renal cell carcinoma by regulating the TGF-?/Smad2 signaling pathway. Oncol Rep. 2018;39:101-108 pubmed publisher
    ..highly expressed in five renal cell carcinoma cell lines compared with that in the normal renal tubular epithelial HK2 cell line...
  92. Madan E, Dikshit B, Gowda S, Srivastava C, Sarkar C, Chattopadhyay P, et al. FAT1 is a novel upstream regulator of HIF1? and invasion of high grade glioma. Int J Cancer. 2016;139:2570-82 pubmed publisher
    ..a substantial reduction in the expression of HIF1? and its downstream target genes like CA9, GLUT1, VEGFA, MCT4, HK2, BNIP3 and REDD1, as well as a significant reduction in the invasiveness in GBM cells...