HOOK1

Summary

Gene Symbol: HOOK1
Description: hook microtubule tethering protein 1
Alias: HK1, protein Hook homolog 1, h-hook1, hHK1, hook homolog 1
Species: human
Products:     HOOK1

Top Publications

  1. Mendoza Lujambio I, Burfeind P, Dixkens C, Meinhardt A, Hoyer Fender S, Engel W, et al. The Hook1 gene is non-functional in the abnormal spermatozoon head shape (azh) mutant mouse. Hum Mol Genet. 2002;11:1647-58 pubmed
    ..We have isolated and characterized murine Hook1 cDNA and analyzed the corresponding genomic structure...
  2. Kr mer H, Phistry M. Genetic analysis of hook, a gene required for endocytic trafficking in drosophila. Genetics. 1999;151:675-84 pubmed
    ..The importance of all three domains for Hook function was confirmed by their conservation between two Drosophila and two human Hook proteins...
  3. Walenta J, Didier A, Liu X, Kramer H. The Golgi-associated hook3 protein is a member of a novel family of microtubule-binding proteins. J Cell Biol. 2001;152:923-34 pubmed
    ..Because overexpression of Hook3 caused fragmentation of the Golgi complex, we propose that Hook3 participates in defining the architecture and localization of the mammalian Golgi complex. ..
  4. Xu L, Sowa M, Chen J, Li X, Gygi S, Harper J. An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex. Mol Biol Cell. 2008;19:5059-71 pubmed publisher
    ..complex, the FHF complex, containing FTS, members of the microtubule-binding Hook family of coiled-coil proteins (Hook1, Hook2, and Hook3), and a previously uncharacterized 107-kDa protein, FTS and Hook Interacting Protein (FHIP)...
  5. Luiro K, Yliannala K, Ahtiainen L, Maunu H, Jarvela I, Kyttälä A, et al. Interconnections of CLN3, Hook1 and Rab proteins link Batten disease to defects in the endocytic pathway. Hum Mol Genet. 2004;13:3017-27 pubmed
    ..BTN2 encodes Btn2p, a proposed homologue to a novel microtubule-binding protein Hook1, which regulates endocytosis in Drosophila...
  6. Cotroneo E, Ashek A, Wang L, Wharton J, Dubois O, Bozorgi S, et al. Iron homeostasis and pulmonary hypertension: iron deficiency leads to pulmonary vascular remodeling in the rat. Circ Res. 2015;116:1680-90 pubmed publisher
    ..Along with upregulation of the glucose transporter, glucose transporter 1, and glycolytic genes, hk1 and pdk1, lung fluorine-18-labeled 2-fluoro-2-deoxyglucose ligand uptake was significantly increased in IDD rats...
  7. Liao C, Chen B, Chiang H, Chen C, Chen M, Ke C, et al. Optimizing a Male Reproductive Aging Mouse Model by D-Galactose Injection. Int J Mol Sci. 2016;17: pubmed publisher
    ..The d-gal-injected groups exhibited RNA transcripts of nine spermatogenesis-related genes (Cycl2, Hk1, Pltp, Utp3, Cabyr, Zpbp2, Speer2, Csnka2ip and Katnb1) that were up- or down-regulated by at least two-fold ..
  8. Richardson S, Winistorfer S, Poupon V, Luzio J, Piper R. Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Mol Biol Cell. 2004;15:1197-210 pubmed
    ..Mammalian mVps18 also associated with mVam2 and mVam6 as well as with the microtubule-associated Hook1 protein, an orthologue of the Drosophila Hook protein involved in endosome biogenesis...
  9. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Häkkinen M, Fischer S, et al. GATA4 is a key regulator of steroidogenesis and glycolysis in mouse Leydig cells. Endocrinology. 2015;156:1860-72 pubmed publisher
    ..GATA4-depleted mLTC-1 cells had reduced expression of glycolytic genes (Hk1, Gpi1, Pfkp, and Pgam1), lower intracellular levels of ATP, and increased extracellular levels of glucose...

More Information

Publications114 found, 100 shown here

  1. Villareal M, Sasaki K, Margout D, Savry C, Almaksour Z, Larroque M, et al. Neuroprotective effect of Picholine virgin olive oil and its hydroxycinnamic acids component against β-amyloid-induced toxicity in SH-SY5Y neurotypic cells. Cytotechnology. 2016;68:2567-2578 pubmed
    ..Moreover, VOO upregulated the glycolytic enzymes genes hexokinase (HK1), and phosphofructokinase (PFKM) expression which means that VOO enhanced the energy metabolism of the neurotypic ..
  2. Schrade A, Kyrönlahti A, Akinrinade O, Pihlajoki M, Fischer S, Rodriguez V, et al. GATA4 Regulates Blood-Testis Barrier Function and Lactate Metabolism in Mouse Sertoli Cells. Endocrinology. 2016;157:2416-31 pubmed publisher
    ..Furthermore, Gata4 gene silencing was associated with altered expression of Hk1, Gpi1, Pfkp, Pgam1, Gls2, Pdk3, Pkd4, and Ldhb, genes regulating the production of lactate, a key nutrient that SCs ..
  3. Sarkar H, Arya S, Rai U, Majumdar S. A Study of Differential Expression of Testicular Genes in Various Reproductive Phases of Hemidactylus flaviviridis (Wall Lizard) to Derive Their Association with Onset of Spermatogenesis and Its Relevance to Mammals. PLoS ONE. 2016;11:e0151150 pubmed publisher
    ..Six important genes, Hk1, Nme5, Akap4, Arih1, Rassf7 and Tubb4b were found to be strictly associated with active spermatogenesis in both ..
  4. Waskova Arnostova P, Elsnicova B, Kasparova D, Hornikova D, Kolar F, Novotny J, et al. Cardioprotective adaptation of rats to intermittent hypobaric hypoxia is accompanied by the increased association of hexokinase with mitochondria. J Appl Physiol (1985). 2015;119:1487-93 pubmed publisher
    ..Our results showed significantly elevated expression of HK isoforms (HK1 and HK2) in the hypoxic LV...
  5. Fu Y, Wang L, Yi D, Jin L, Liu J, Zhang Y, et al. Association between maternal single nucleotide polymorphisms in genes regulating glucose metabolism and risk for neural tube defects in offspring. Birth Defects Res A Clin Mol Teratol. 2015;103:471-8 pubmed publisher
    ..16-2.88). No association was found between the other four single nucleotide polymorphisms (LEPR rs1137100, HK1 rs748235, HHEX rs5015480, KCNQ1 rs2237892) and NTD risk...
  6. Liu C, Zhang Y, She X, Fan L, Li P, Feng J, et al. A cytoplasmic long noncoding RNA LINC00470 as a new AKT activator to mediate glioblastoma cell autophagy. J Hematol Oncol. 2018;11:77 pubmed publisher
    ..Higher pAKT activated by LINC00470 inhibited ubiquitination of HK1, which affected glycolysis, and inhibited cell autophagy...
  7. Zhou H, Fang Y, Weinberger P, Ding L, Cowell J, Hudson F, et al. Transgelin increases metastatic potential of colorectal cancer cells in vivo and alters expression of genes involved in cell motility. BMC Cancer. 2016;16:55 pubmed publisher
    ..Changes included increases in HOOK1, SDCCAG8, ENAH/Mena, and TNS1 and decreases in EMB, BCL11B, and PTPRD...
  8. Fouquerel E, Goellner E, Yu Z, Gagné J, Barbi de Moura M, Feinstein T, et al. ARTD1/PARP1 negatively regulates glycolysis by inhibiting hexokinase 1 independent of NAD+ depletion. Cell Rep. 2014;8:1819-1831 pubmed publisher
    ..We then established a proteomics-based PAR interactome after DNA damage and identified hexokinase 1 (HK1) as a PAR binding protein. HK1 activity is suppressed following nuclear ARTD1 activation and binding by PAR...
  9. Dhawan S, Tschen S, Zeng C, Guo T, Hebrok M, MATVEYENKO A, et al. DNA methylation directs functional maturation of pancreatic β cells. J Clin Invest. 2015;125:2851-60 pubmed publisher
    ..DNMT3A bound to the promoters of the genes encoding hexokinase 1 (HK1) and lactate dehydrogenase A (LDHA) - both of which regulate the metabolic switch - and knockdown of these two key ..
  10. Wang C, Wang H, Zhang Y, Guo W, Long C, Wang J, et al. Berberine inhibits the proliferation of human nasopharyngeal carcinoma cells via an Epstein-Barr virus nuclear antigen 1-dependent mechanism. Oncol Rep. 2017;37:2109-2120 pubmed publisher
    ..Viral titer experiments demonstrated that berberine decreased the production of virions in HONE1 and HK1-EBV cells...
  11. Chen Q, Qin S, Liu Y, Hong M, Qian C, Keller E, et al. IGFBP6 is a novel nasopharyngeal carcinoma prognostic biomarker. Oncotarget. 2016;7:68140-68150 pubmed publisher
    ..real-time PCR, ELISA and western blot assays to measure IGFBP6 levels in five NPC cell lines (CNE1, CNE2, HONE1, HK1 and SUNE1). All the cell lines expressed IGFBP6, but at different levels, reflecting disease heterogeneity...
  12. Xinhong L, Zhen L, Fu J, Wang L, Yang Q, Li P, et al. Quantitative proteomic profiling indicates the difference in reproductive efficiency between Meishan and Duroc boar spermatozoa. Theriogenology. 2018;116:71-82 pubmed publisher
    ..Interestingly, essential enzymes in Glycolysis/Gluconeogenesis, such as HK1, ALDH2, LDHA and LDHC, were markedly up-regulated in Meishan spermatozoa compared to Duroc spermatozoa...
  13. Vartanian A, Agnihotri S, Wilson M, Burrell K, Tonge P, Alamsahebpour A, et al. Targeting hexokinase 2 enhances response to radio-chemotherapy in glioblastoma. Oncotarget. 2016;7:69518-69535 pubmed publisher
    ..of GBM, we showed that inducible knockdown of HK2 altered tumor metabolism, which could not be recapitulated by HK1 or HK3 loss...
  14. Cheng Y, Ho R, Chan K, Kan R, Tung E, Lung H, et al. Anti-angiogenic pathway associations of the 3p21.3 mapped BLU gene in nasopharyngeal carcinoma. Oncogene. 2015;34:4219-28 pubmed publisher
    ..Overexpressed BLU only inhibited VEGF165 expression in differentiated squamous NPC HK1 cells, but also showed an anti-angiogenic effect in the animal assay, revealing a complicated mechanism regulating ..
  15. Falch C, Sundaram A, Øystese K, Normann K, Lekva T, Silamikelis I, et al. Gene expression profiling of fast- and slow-growing non-functioning gonadotroph pituitary adenomas. Eur J Endocrinol. 2018;178:295-307 pubmed publisher
    ..05). These were PCDH18, UNC5D, EMCN, MYO1B, GPM6A and six EMT-related genes (SPAG9, SKIL, MTDH, HOOK1, CNOT6L and PRKACB)...
  16. Wang M, Wang W, Wang J, Zhang J. MiR-182 promotes glucose metabolism by upregulating hypoxia-inducible factor 1α in NSCLC cells. Biochem Biophys Res Commun. 2018;504:400-405 pubmed publisher
    ..a panel of genes controlling glucose metabolism, miR-182 exhibited significantly influence on ENO1, GLUT1, HIF-1α, HK1, HK2, LDHA and PDK1, especially HIF-1α...
  17. Park M, Lim J, Lee H, Na K, Lee M, Kang C, et al. Distinct Protein Expression Profiles of Solid-Pseudopapillary Neoplasms of the Pancreas. J Proteome Res. 2015;14:3007-14 pubmed publisher
    ..Molecules involved in glycolysis, including PKM2, ENO2, and HK1, were overexpressed in accordance to their mRNA levels...
  18. Neale B, Medland S, Ripke S, Anney R, Asherson P, Buitelaar J, et al. Case-control genome-wide association study of attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2010;49:906-20 pubmed publisher
    ..The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1...
  19. Varanasi S, Jaggi U, Hay N, Rouse B. Hexokinase II may be dispensable for CD4 T cell responses against a virus infection. PLoS ONE. 2018;13:e0191533 pubmed publisher
    ..Deletion of HK2 led to enhanced levels of HK1 indicative of a compensatory mechanism...
  20. Lee I, Olenick M, Boczkowska M, Franzini Armstrong C, Holzbaur E, Dominguez R. A conserved interaction of the dynein light intermediate chain with dynein-dynactin effectors necessary for processivity. Nat Commun. 2018;9:986 pubmed publisher
    ..binding studies map these interactions to a conserved helix within LIC1 and to N-terminal fragments of Hook1, Hook3, BICD2, and Spindly...
  21. Xu S, Zhou T, Doh H, Trinh K, Catapang A, Lee J, et al. An HK2 antisense oligonucleotide induces synthetic lethality in HK1-HK2+ multiple myeloma. Cancer Res. 2019;: pubmed publisher
    Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers express hexokinase 2 (HK2) and many co-express HK1 and HK2...
  22. Wu J, Chen X, Siu K. Isolation and structure characterization of an antioxidative glycopeptide from mycelial culture broth of a medicinal fungus. Int J Mol Sci. 2014;15:17318-32 pubmed publisher
    ..from the lower Mw fraction of exopolysaccharide (EPS) produced by a medicinal fungus Cordyceps sinensis Cs-HK1. Its carbohydrate moiety was mainly composed of glucose and mannose at 3.2:1...
  23. Olenick M, Dominguez R, Holzbaur E. Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons. J Cell Biol. 2019;218:220-233 pubmed publisher
    ..We find that the dynein effector Hook1 mediates transport of TrkB-BDNF-signaling endosomes in primary hippocampal neurons...
  24. Zhang Z, Hendrickson W. Structural characterization of the predominant family of histidine kinase sensor domains. J Mol Biol. 2010;400:335-53 pubmed publisher
    ..crystal structures were determined from five sensor domains representative of the most populated family, family HK1, found in a bioinformatic analysis of predicted sensor domains from transmembrane HKs...
  25. Martins de Souza D, Alsaif M, Ernst A, Harris L, Aerts N, Lenaerts I, et al. The application of selective reaction monitoring confirms dysregulation of glycolysis in a preclinical model of schizophrenia. BMC Res Notes. 2012;5:146 pubmed publisher
    ..The selected enzymes were hexokinase 1 (Hk1), aldolase C (Aldoc), triosephosphate isomerase (Tpi1), glyceraldehyde-3-phosphate dehydrogenase (Gapdh), ..
  26. Tan S, Sim S, Khoo A. Matrix association region/scaffold attachment region (MAR/SAR) sequence: its vital role in mediating chromosome breakages in nasopharyngeal epithelial cells via oxidative stress-induced apoptosis. BMC Mol Biol. 2018;19:15 pubmed publisher
    ..was used to induce apoptosis in normal nasopharyngeal epithelial cells (NP69) and NPC cells (HK1). Nested inverse polymerase chain reaction was employed to identify the AF9 gene cleavages...
  27. Wang F, Wang Y, Zhang B, Zhao L, Lyubasyuk V, Wang K, et al. A missense mutation in HK1 leads to autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2014;55:7159-64 pubmed publisher
    ..2:c.2539G>A, p.E847K) in hexokinase 1 (HK1) that segregated with the disease phenotype in the family...
  28. Hoe S, Tan L, Jamal J, Peh S, Ng C, Zhang W, et al. Evaluation of stem-like side population cells in a recurrent nasopharyngeal carcinoma cell line. Cancer Cell Int. 2014;14:101 pubmed publisher
    ..We used Hoechst 33342 to identify the SP from non-SP (NSP) cells in HK1 NPC cell line and xeno-284 NPC xenograft...
  29. Ciribilli Y, Singh P, Inga A, Borlak J. c-Myc targeted regulators of cell metabolism in a transgenic mouse model of papillary lung adenocarcinoma. Oncotarget. 2016;7:65514-65539 pubmed publisher
    ..Ribosomal-Protein-SA(RPSA), Nucleophosmin/Nucleoplasmin-3(NPM3) and Hexokinase-1(HK1) confirmed c-Myc functional relevance and ChIP assays with HEK293T cells over-expressing ectopic c-Myc demonstrated ..
  30. Wong C, Ma B, Hui C, Lo K, Hui E, Chan A. Preclinical evaluation of ribociclib and its synergistic effect in combination with alpelisib in non-keratinizing nasopharyngeal carcinoma. Sci Rep. 2018;8:8010 pubmed publisher
    ..IC50 concentrations: HK1?=?1.42?±?0.23?µM; HK1-LMP1?=?2.18?±?0.70?µM and C666-1?=?8.26?±?0.92?µM)...
  31. An P, Miljkovic I, Thyagarajan B, Kraja A, Daw E, Pankow J, et al. Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS). Metabolism. 2014;63:461-8 pubmed publisher
    ..A linear mixed effects model was used for association testing. Two known loci at GCK rs730497 (or rs2908282) and HK1 rs17476364 were confirmed (p<5e-8)...
  32. Zhang W, Qiu M, WANG X, Sun K, Zheng Y, Jing Z. Up-regulation of hexokinase1 in the right ventricle of monocrotaline induced pulmonary hypertension. Respir Res. 2014;15:119 pubmed publisher
    ..Expression of hexokinase 1 (HK1) mRNA began to increase in the right ventricle of the MCT-3w group and MCT-4w group, while the expression of ..
  33. Sang Y, Cheng C, Zeng Y, Kang T. Snail promotes metastasis of nasopharyngeal carcinoma partly by down-regulating TEL2. Cancer Commun (Lond). 2018;38:58 pubmed publisher
    ..TEL2 expression was analyzed in three representative NPC cell lines expressing low levels of Snail (S26, 6-10B, HK1) and two cell lines expressing high levels of Snail (S18, 5-8F)...
  34. Fu F, Wang T, Wu Z, Feng Y, Wang W, Zhou S, et al. HMGA1 exacerbates tumor growth through regulating the cell cycle and accelerates migration/invasion via targeting miR-221/222 in cervical cancer. Cell Death Dis. 2018;9:594 pubmed publisher
    High-mobility group AT-hook1 (HMGA1, formerly HMG-I/Y), an architectural transcription factor, participates in a number of tumor biological processes. However, its effect on cervical cancer remains largely indistinct...
  35. Rocha F, Dias J, Engrola S, Gavaia P, Geurden I, Dinis M, et al. Glucose metabolism and gene expression in juvenile zebrafish (Danio rerio) challenged with a high carbohydrate diet: effects of an acute glucose stimulus during late embryonic life. Br J Nutr. 2015;113:403-13 pubmed publisher
    ..On glycolysis, the expression levels of hexokinase 1 (HK1) and phosphofructokinase-6 (6PFK) were up-regulated in the visceral and muscle tissues, respectively, of juveniles ..
  36. Norman G, Yang C, Ostendorff H, Shums Z, Lim M, Wang J, et al. Anti-kelch-like 12 and anti-hexokinase 1: novel autoantibodies in primary biliary cirrhosis. Liver Int. 2015;35:642-51 pubmed publisher
    ..recombinant protein microarrays, we identified two potential biomarkers, kelch-like 12 (KLHL12) and hexokinase-1 (HK1), in primary biliary cirrhosis (PBC)...
  37. Cao J, Huang Y, Jiao Sun -, Lan X, Ge M. Clinicopathological and prognostic significance of SHP2 and Hook1 expression in patients with thyroid carcinoma. Hum Pathol. 2018;81:105-112 pubmed publisher
    ..Src homology region 2-containing protein tyrosine phosphatase 2 (SHP2) and Hook microtubule tethering protein 1 (Hook1) expression in TC...
  38. Mao Y, Song A, Wang Z, Yao Z, Wu J. Protection of Bifidobacterial cells against antibiotics by a high molecular weight exopolysaccharide of a medicinal fungus Cs-HK1 through physical interactions. Int J Biol Macromol. 2018;119:312-319 pubmed publisher
    ..was to assess the protective effect of exopolysaccharide (EPS) produced by a medicinal fungus Cordyceps sinensis Cs-HK1 on Bifidobacteria against antibiotic inhibition...
  39. Bertheau L, Djeghdir I, Foureau E, Chefdor F, Glevarec G, Oudin A, et al. Insights into B-type RR members as signaling partners acting downstream of HPt partners of HK1 in the osmotic stress response in Populus. Plant Physiol Biochem. 2015;94:244-52 pubmed publisher
    ..In Populus, three HPts and five B-type RRs were previously identified as interacting partners of HK1, the Arabidopsis AHK1 homolog...
  40. Sullivan L, Koboldt D, Bowne S, Lang S, Blanton S, Cadena E, et al. A dominant mutation in hexokinase 1 (HK1) causes retinitis pigmentosa. Invest Ophthalmol Vis Sci. 2014;55:7147-58 pubmed publisher
    ..2539G>A, p.Glu847Lys) in hexokinase 1 (HK1) present in all affected individuals and absent from normal controls...
  41. Caimano M, Dunham Ems S, Allard A, Cassera M, Kenedy M, Radolf J. Cyclic di-GMP modulates gene expression in Lyme disease spirochetes at the tick-mammal interface to promote spirochete survival during the blood meal and tick-to-mammal transmission. Infect Immun. 2015;83:3043-60 pubmed publisher
    ..burgdorferi, the Lyme disease spirochete, couples environmental sensing and gene regulation primarily via the Hk1/Rrp1 two-component system (TCS) and Rrp2/RpoN/RpoS pathways...
  42. Moon J, Hisata S, Park M, DeNicola G, Ryter S, Nakahira K, et al. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Rep. 2015;12:102-115 pubmed publisher
    ..Moreover, we demonstrate that hexokinase 1 (HK1)-dependent glycolysis, under the regulation of mTORC1, represents a critical metabolic pathway for NLRP3 ..
  43. Binderup T, Knigge U, Federspiel B, Sommer P, Hasselby J, Loft A, et al. Gene Expression of Glucose Transporter 1 (GLUT1), Hexokinase 1 and Hexokinase 2 in Gastroenteropancreatic Neuroendocrine Tumors: Correlation with F-18-fluorodeoxyglucose Positron Emission Tomography and Cellular Proliferation. Diagnostics (Basel). 2013;3:372-84 pubmed publisher
    ..Using real-time PCR, gene expression of GLUT1, HK1 and HK2 were studied in 34 neuroendocrine tumors (NETs) in comparison with 14 colorectal adenocarcinomas (CRAs)...
  44. Wasil L, Shair K. Modified Anoikis Assay That Functionally Segregates Epstein-Barr Virus LMP1 Strains into Two Groups. J Virol. 2018;92: pubmed publisher
    ..Expression of LMP1 promoted the outgrowth of the NPC cell line HK1 following anoikis induction that was not attributed to enhanced cell survival in suspension or reattachment...
  45. Qiu M, Zhang R, Zheng Y, Zhang W. [Glycoltic metabolism gene changes in left and right ventricles in experimental rat pulmonary arterial hypertension model]. Zhonghua Xin Xue Guan Bing Za Zhi. 2014;42:1010-6 pubmed
    ..05). The HK1, HK2, PDHα1 and LDHA mRNA expression in the left ventricle and LDHA mRNA expression were significantly ..
  46. Herrmann L, Wiegmann C, Arsalan Werner A, Hilbrich I, Jäger C, Flach K, et al. Hook proteins: association with Alzheimer pathology and regulatory role of hook3 in amyloid beta generation. PLoS ONE. 2015;10:e0119423 pubmed publisher
    ..In this study we show that Hook1 and Hook3 are expressed in neurons while Hook2 is predominantly expressed in astrocytes...
  47. Liu Z, Luo Q, Guo C. Bim and VDAC1 are hierarchically essential for mitochondrial ATF2 mediated cell death. Cancer Cell Int. 2015;15:34 pubmed publisher
    ..Genotoxic stress enabled mitochondrial ATF2 accumulation, perturbing the HK1-VDAC1 complex, increasing mitochondrial permeability, and promoting apoptosis...
  48. Caves E, Cook S, Lee N, Stoltz D, Watkins S, Shair K. Air-Liquid Interface Method To Study Epstein-Barr Virus Pathogenesis in Nasopharyngeal Epithelial Cells. mSphere. 2018;3: pubmed publisher
    ..In the EBV-infected NPC HK1 cell line, ALI culture resulted in the completion of EBV reactivation, with global induction of the lytic cascade, ..
  49. Sun F, Huang Q, Wu J. Rheological behaviors of an exopolysaccharide from fermentation medium of a Cordyceps sinensis fungus (Cs-HK1). Carbohydr Polym. 2014;114:506-13 pubmed publisher
    ..Based on Winter-Chambon criterion, EPS formed gel at 2.6 mg/mL (cgel) and showed typical weak gel from temperature ramp and repetitive strain sweep. ..
  50. Jian W, Zhang L, Siu K, Song A, Wu J. Formation and Physiochemical Properties of Silver Nanoparticles with Various Exopolysaccharides of a Medicinal Fungus in Aqueous Solution. Molecules. 2016;22: pubmed publisher
    ..previous study, a high molecular weight (MW) fraction of exopolysaccharides (EPS) produced by a medicinal fungus Cs-HK1 has been shown useful for green and facile synthesis of AgNPs in water...
  51. Kudryavtseva A, Fedorova M, Zhavoronkov A, Moskalev A, Zasedatelev A, Dmitriev A, et al. Effect of lentivirus-mediated shRNA inactivation of HK1, HK2, and HK3 genes in colorectal cancer and melanoma cells. BMC Genet. 2016;17:156 pubmed publisher
    ..The purpose of the present study was to investigate the effect of silencing of hexokinase genes (HK1, HK2, and HK3) in colorectal cancer (HT-29, SW 480, HCT-15, RKO, and HCT 116) and melanoma (MDA-MB-435S and SK-MEL-..
  52. Perrin Cocon L, Aublin Gex A, Diaz O, Ramière C, Peri F, Andre P, et al. Toll-like Receptor 4-Induced Glycolytic Burst in Human Monocyte-Derived Dendritic Cells Results from p38-Dependent Stabilization of HIF-1? and Increased Hexokinase II Expression. J Immunol. 2018;201:1510-1521 pubmed publisher
    ..LPS strongly enhanced the expression of HK2, whereas HK3 was reduced, HK1 remained unchanged, and HK4 was not expressed...
  53. Behar V, Pahima H, Kozminsky Atias A, Arbel N, Loeb E, Herzberg M, et al. A Hexokinase 2 Modulator for Field-Directed Treatment of Experimental Actinic Keratoses. J Invest Dermatol. 2018;138:2635-2643 pubmed publisher
    ..Thus, Comp-1 may address a significant unmet medical need for a non-irritating efficacious topical actinic keratosis treatment. ..
  54. Cho M, Park C, Park M, Kim W, Cho A, Kim H. Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹⁸F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors. PLoS ONE. 2015;10:e0141413 pubmed publisher
    ..positively with tumor size, risk grade, and expression levels of glucose transporter 1 (GLUT1), hexokinase 1 (HK1), and lactate dehydrogenase A (LDHA). Elevated HK and LDH activity was found in high-risk tumors...
  55. Cavalcante I, Zerbini M, Alencar G, Mariani B, Buchpiguel C, Almeida M, et al. High 18F-FDG uptake in PMAH correlated with normal expression of Glut1, HK1, HK2, and HK3. Acta Radiol. 2016;57:370-7 pubmed publisher
    ..is a correlation between 18F-FDG high uptake and the expression levels of the glycolytic pathway components GLUT1, HK1, HK2, and HK3 in PMAH...
  56. Galcheva S, Al Khawaga S, Hussain K. Diagnosis and management of hyperinsulinaemic hypoglycaemia. Best Pract Res Clin Endocrinol Metab. 2018;32:551-573 pubmed publisher
    ..that play a key role in regulating insulin secretion (ABCC8, KCNJ11, GLUD1, GCK, HADH, SLC16A1, UCP2, HNF4A, HNF1A, HK1, PGM1, PPM2, CACNA1D, FOXA2)...
  57. Jackson J, O Donnell J, Krizman E, Robinson M. Displacing hexokinase from mitochondrial voltage-dependent anion channel impairs GLT-1-mediated glutamate uptake but does not disrupt interactions between GLT-1 and mitochondrial proteins. J Neurosci Res. 2015;93:999-1008 pubmed publisher
    ..the glycolytic enzyme hexokinase (HK)-1 might physically form a scaffold to link GLT-1 and mitochondria because HK1 is known to interact with the outer mitochondrial membrane protein voltage-dependent anion channel (VDAC)...
  58. Suh S, Kim Y, Goh T, Jeong D, Lee C, Jang J, et al. mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas. Yonsei Med J. 2018;59:746-753 pubmed publisher
    ..Expression data for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1-3), glucose-6-phosphate dehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1-4) mRNA were ..
  59. Héricourt F, Chefdor F, Djeghdir I, Larcher M, Lafontaine F, Courdavault V, et al. Functional Divergence of Poplar Histidine-Aspartate Kinase HK1 Paralogs in Response to Osmotic Stress. Int J Mol Sci. 2016;17: pubmed
    ..As conserved duplicates reflect the selective pressures imposed by the environmental requirements on the species, our results emphasize the importance of HK1 gene duplication in poplar adaptation to drought stress.
  60. Wasil L, Wei L, Chang C, Lan L, Shair K. Regulation of DNA Damage Signaling and Cell Death Responses by Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) and LMP2A in Nasopharyngeal Carcinoma Cells. J Virol. 2015;89:7612-24 pubmed publisher
    ..In this study, LMP1 and LMP2A were coexpressed in the EBV-negative NPC cell line HK1 and examined for combined effects in response to genotoxic treatments...
  61. Zhu Y, Zou C, Zhang Z, Qian C, Yang X, Shi J, et al. MEK inhibitor diminishes nasopharyngeal carcinoma (NPC) cell growth and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expressions. Tumour Biol. 2015;36:8811-8 pubmed publisher
    ..firstly determined chemokine receptor CCR2 and CXCR6 expressions in clinical specimens and CNE2, SUNE1, CNE1, and HK1 cell lines. Then, we measured chemokine CCL2 and CXCL16 production in these NPC cell lines by ELISA...
  62. Safka Brožková D, Haberlova J, Mazanec R, Lastuvkova J, Seeman P. HSMNR belongs to the most frequent types of hereditary neuropathy in the Czech Republic and is twice more frequent than HMSNL. Clin Genet. 2016;90:161-5 pubmed publisher
    ..called CMT4G, is an autosomal recessive inherited peripheral neuropathy (IPN) caused by a founder mutation in the HK1 gene. HMSNR affects only patients with Roma origin, similar to the better known HMSN type Lom clarified earlier...
  63. Shipton F, Khoo T, Hossan M, Wiart C. Activity of Pericampylus glaucus and periglaucine A in vitro against nasopharangeal carcinoma and anti-inflammatory activity. J Ethnopharmacol. 2017;198:91-97 pubmed publisher
    ..Cytotoxicity was tested using the human lung epithelial cell line MRC-5 and nasopharangeal carcinoma cell line HK1 in the MTT assay...
  64. Kolar D, Gresikova M, Waskova Arnostova P, Elsnicova B, Kohutova J, Hornikova D, et al. Adaptation to chronic continuous hypoxia potentiates Akt/HK2 anti-apoptotic pathway during brief myocardial ischemia/reperfusion insult. Mol Cell Biochem. 2017;432:99-108 pubmed publisher
    ..The CNH resulted in increased levels of HK1 and HK2 proteins and the total HK activity after ischemia compared to corresponding normoxic group...
  65. Kavanagh Williamson M, Coombes N, Juszczak F, Athanasopoulos M, Khan M, Eykyn T, et al. Upregulation of Glucose Uptake and Hexokinase Activity of Primary Human CD4+ T Cells in Response to Infection with HIV-1. Viruses. 2018;10: pubmed publisher
    ..The investigation of glycolytic enzymes demonstrated activation-dependent expression of hexokinases HK1 and HK2 in human CD4+ T cells, and a highly significant increase in cellular hexokinase enzyme activity in response ..
  66. Kan R, Shuen W, Lung H, Cheung A, Dai W, Kwong D, et al. NF-κB p65 Subunit Is Modulated by Latent Transforming Growth Factor-β Binding Protein 2 (LTBP2) in Nasopharyngeal Carcinoma HONE1 and HK1 Cells. PLoS ONE. 2015;10:e0127239 pubmed publisher
    ..Therefore, the data suggest that the overall up-regulation of p65 expression and the loss of this candidate ECM tumor suppressor are milestone events contributing to NPC development. ..
  67. Kharrat M, Kamoun Y, Kamoun F, Ellouze E, Maalej M, Fendri Kriaa N, et al. Clinical, Molecular, and Computational Analysis in Patients With a Novel Double Mutation and a New Synonymous Variant in MeCP2: Report of the First Missense Mutation Within the AT-hook1 Cluster in Rett Syndrome. J Child Neurol. 2017;32:694-703 pubmed publisher
    ..G185 V in the AT-hook1. In conclusion, clinical, molecular, and in silico investigations in the studied patients have been proven to be ..
  68. Stanley C. Perspective on the Genetics and Diagnosis of Congenital Hyperinsulinism Disorders. J Clin Endocrinol Metab. 2016;101:815-26 pubmed publisher
    ..are now 11 genes associated with monogenic forms of HI (ABCC8, KCNJ11, GLUD1, GCK, HADH1, UCP2, MCT1, HNF4A, HNF1A, HK1, PGM1), as well as several syndromic genetic forms of HI (eg, Beckwith-Wiedemann, Kabuki, and Turner syndromes)...
  69. Teng L, Ahmad M, Ng W, Sabaratnam S, Rasan M, Parhar I, et al. Gonadotropin‑releasing hormone inhibits the proliferation and motility of nasopharyngeal carcinoma cells. Mol Med Rep. 2015;12:4909-16 pubmed publisher
    ..present study examined the expression of the GnRH‑R transcript in NPC and investigated the phenotypic changes in HK1 cells, a recurrent NPC‑derived cell line, upon receiving GnRH treatment...
  70. Daiger S, Sullivan L, Bowne S, Koboldt D, Blanton S, Wheaton D, et al. Identification of a Novel Gene on 10q22.1 Causing Autosomal Dominant Retinitis Pigmentosa (adRP). Adv Exp Med Biol. 2016;854:193-200 pubmed publisher
    ..Whole-exome next-generation sequencing revealed a missense mutation in hexokinase 1, HK1 c.2539G > A, p.Glu847Lys, tracking with disease in all affected family members...
  71. Massari F, Ciccarese C, Santoni M, Iacovelli R, Mazzucchelli R, Piva F, et al. Metabolic phenotype of bladder cancer. Cancer Treat Rev. 2016;45:46-57 pubmed publisher
    ..genes (SRC-3, glucose transporter type 1 [GLUT1], GLUT3, lactic dehydrogenase A [LDHA], LDHB, hexokinase 1 [HK1], HK2, pyruvate kinase type M [PKM], and hypoxia-inducible factor 1-alpha [HIF-1α]), resulting in an ..
  72. Masre S, Rath N, Olson M, Greenhalgh D. ROCK2/rasHa co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression. Oncogene. 2017;36:2529-2542 pubmed publisher
    ..ROCKer) were crossed with mice expressing epidermal-activated rasHa (HK1.ras1205). At 8 weeks, 4HT-treated K14.ROCKer/HK1...
  73. Bauer W, Luthra A, Zhu G, Radolf J, Malkowski M, Caimano M. Structural characterization and modeling of the Borrelia burgdorferi hybrid histidine kinase Hk1 periplasmic sensor: A system for sensing small molecules associated with tick feeding. J Struct Biol. 2015;192:48-58 pubmed publisher
    ..The Hk1/Rrp1 two-component system (TCS) in Borrelia burgdorferi consists of a hybrid histidine kinase and a response ..
  74. Gao Y, Xu D, Yu G, Liang J. Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer. Int J Clin Exp Pathol. 2015;8:9264-71 pubmed
    Hexokinase 1 (HK1) and pyruvate kinase M2 (PKM2) are two key regulators in glycosis and oncogenic markers in cancers...
  75. Krasnov G, Dmitriev A, Sadtritdinova A, Fedorova M, Snezhkina A, Melnikova N, et al. [Evaluation of Gene Expression of Hexokinases in Colorectal Cancer with the Use of Bioinformatics Methods]. Biofizika. 2015;60:1050-6 pubmed
    ..The glycolysis activation can be caused by overexpression of hexokinases, primarily HK1 and HK2...
  76. Yang M, Xiong Z, Li W, Jia M, Liu G. [Interaction of DNAJB13 with HK1 in mouse]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:1684-1688 pubmed
    To investigate the presence of interactions between DNAJB13 and HK1. The open reading frame of Dnajb13 gene was amplified from mouse testis cDNA by PCR...
  77. Yalvac M, Amornvit J, Chen L, Shontz K, Lewis S, Sahenk Z. AAV1.NT-3 gene therapy increases muscle fiber diameter through activation of mTOR pathway and metabolic remodeling in a CMT mouse model. Gene Ther. 2018;25:129-138 pubmed publisher
    ..In parallel, the expression levels of the mitochondrial biogenesis regulator PGC1?, and the markers of glycolysis (HK1 and PK1) increased in the TrJ muscle...
  78. Bramer S, Macedo A, Klein C. Hexokinase 2 drives glycogen accumulation in equine endometrium at day 12 of diestrus and pregnancy. Reprod Biol Endocrinol. 2017;15:4 pubmed publisher
    ..mRNA expression of glycogen-metabolizing enzymes (HK1, HK2, GSK3B, GYS1, PEPCK, PKM, PYGM) in endometrial samples were compared among mares in anestrus, estrus, and at ..
  79. Zhao W, Ma N, Wang S, Mo Y, Zhang Z, Huang G, et al. RERG suppresses cell proliferation, migration and angiogenesis through ERK/NF-κB signaling pathway in nasopharyngeal carcinoma. J Exp Clin Cancer Res. 2017;36:88 pubmed publisher
    ..5-Aza-2'-deoxycytidine (Aza) or combined with trichostatin A (TSA) were treated to three NPC cell lines (HK1, C666-1 and HK1_EBV)...
  80. Koralkova P, Mojzikova R, van Oirschot B, Macartney C, Timr P, Vives Corrons J, et al. Molecular characterization of six new cases of red blood cell hexokinase deficiency yields four novel mutations in HK1. Blood Cells Mol Dis. 2016;59:71-6 pubmed publisher
    ..A total of six different mutations were detected in HK1, four of them described here for the first time: c.2599C>T p.(His867Tyr), c.1799C>T p.(Thr600Met), c...
  81. Rodrigues R, Bozza F, Hanrahan C, Wang L, Wu Q, Hoffman J, et al. 18F-fluoro-2-deoxyglucose PET informs neutrophil accumulation and activation in lipopolysaccharide-induced acute lung injury. Nucl Med Biol. 2017;48:52-62 pubmed publisher
    ..resulted in increased uptake of 14C-2DG, expression of GLUT 3 and GLUT 4 and expression and increased HK1 activity...
  82. Annabelle T, Karine R, Marie Dominique B, Stéphane D, Karine G. Kinetics of expression of genes involved in glucose metabolism after the last meal in overfed mule ducks. Mol Cell Biochem. 2017;430:127-137 pubmed publisher
    ..In the liver, GLUT2 and HK1 are upregulated at the same time and seem to work together to import glucose...
  83. Hua S, Lei L, Deng L, Weng X, Liu C, Qi X, et al. miR-139-5p inhibits aerobic glycolysis, cell proliferation, migration, and invasion in hepatocellular carcinoma via a reciprocal regulatory interaction with ETS1. Oncogene. 2018;37:1624-1636 pubmed publisher
    ..miR-139-5p regulated hexokinase 1 (HK1) and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) expression by directly targeting the ..
  84. Break M, Hossan M, Khoo Y, Qazzaz M, Al Hayali M, Chow S, et al. Discovery of a highly active anticancer analogue of cardamonin that acts as an inducer of caspase-dependent apoptosis and modulator of the mTOR pathway. Fitoterapia. 2018;125:161-173 pubmed publisher
    ..of cardamonin with enhanced anticancer activity, 19 analogues were synthesized and tested against A549 and HK1 cell lines...
  85. Fabre S, Gully D, Poitout A, Patrel D, Arrighi J, Giraud E, et al. Nod Factor-Independent Nodulation in Aeschynomene evenia Required the Common Plant-Microbe Symbiotic Toolkit. Plant Physiol. 2015;169:2654-64 pubmed publisher
    ..between nodule organogenesis and infection processes; and Symbiosis Receptor Kinase (SYMRK) and Histidine Kinase1 (HK1), which act upstream and downstream of CCaMK, respectively...
  86. He X, Lin X, Cai M, Zheng X, Lian L, Fan D, et al. Overexpression of Hexokinase 1 as a poor prognosticator in human colorectal cancer. Tumour Biol. 2016;37:3887-95 pubmed publisher
    It has been suggested that hexokinase 1 (HK1) is involved in tumorigenesis. However, the expression dynamics of HK1 and its prognostic significance in human colorectal cancer (CRC) still remain unclear...
  87. Hu T, Jiang C, Huang Q, Sun F. A comb-like branched β-D-glucan produced by a Cordyceps sinensis fungus and its protective effect against cyclophosphamide-induced immunosuppression in mice. Carbohydr Polym. 2016;142:259-67 pubmed publisher
    An exopolysaccharide (EPS) was fractionated from fermentation media of a Cordyceps sinensis fungus (Cs-HK1) by ethanol precipitation at 2/5 volume ratio of ethanol/media...
  88. Schwarz T, Prieler B, Schmid J, Grzmil P, Neesen J. Ccdc181 is a microtubule-binding protein that interacts with Hook1 in haploid male germ cells and localizes to the sperm tail and motile cilia. Eur J Cell Biol. 2017;96:276-288 pubmed publisher
    Disruption of murine Hook1 results in a disturbed spermatogenesis and consequently leads to male infertility in mice...
  89. Maldonado Baez L, Cole N, KRAMER H, Donaldson J. Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1. J Cell Biol. 2013;201:233-47 pubmed publisher
    ..We found that Hook1, a microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 ..
  90. Olenick M, Tokito M, Boczkowska M, Dominguez R, Holzbaur E. Hook Adaptors Induce Unidirectional Processive Motility by Enhancing the Dynein-Dynactin Interaction. J Biol Chem. 2016;291:18239-51 pubmed publisher
    ..Here we investigate the role of mammalian Hook proteins, Hook1 and Hook3, as potential motor adaptors...
  91. Sun X, Zhang Q, Chen W, Hu Q, Lou Y, Fu Q, et al. Hook1 inhibits malignancy and epithelial-mesenchymal transition in hepatocellular carcinoma. Tumour Biol. 2017;39:1010428317711098 pubmed publisher
    b>Hook1 is a member of the hook family of coiled-coil proteins, which is recently found to be associated with malignant tumors. However, its biological function in hepatocellular carcinoma is yet unknown...
  92. Lu H, Zhu H. Effect of siRNA-mediated gene silencing of transketolase on A549 lung cancer cells. Oncol Lett. 2017;14:5906-5912 pubmed publisher
    ..sorbitol dehydrogenase (SORD), phosphoribosyl pyrophosphate synthetase 1 (PRPS1) and hexokinase 1 (HK1) were detected by RT-qPCR. siRNA-C at 50 nmol/l was selected for the subsequent experiments...