Gene Symbol: HOMER3
Description: homer scaffold protein 3
Alias: HOMER-3, VESL3, homer protein homolog 3, Homer, neuronal immediate early gene, 3, homer homolog 3, homer scaffolding protein 3
Species: human
Products:     HOMER3

Top Publications

  1. Huang G, Huso D, Bouyain S, Tu J, McCorkell K, May M, et al. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008;319:476-81 pubmed publisher
    ..We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell activation...
  2. Xiao B, Tu J, Petralia R, Yuan J, Doan A, Breder C, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21:707-16 pubmed
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties. ..
  3. Tu J, Xiao B, Yuan J, Lanahan A, Leoffert K, Li M, et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21:717-26 pubmed
    ..These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function. ..
  4. Xu X, Ren H, Li L, Wang J, Fechner K, Guan H. Anti-Homer-3 antibody associated cerebellar ataxia: A rare case report and literature review. J Neuroimmunol. 2019;330:155-158 pubmed publisher
    ..Our report indicated immune-mediated causes should be considered in the context of 'idiopathic' cerebellar ataxia and immunotherapy could have therapeutic effects. ..
  5. Kyratzi E, Liakos A, Papadogiannaki G, Efthimiopoulos S. Structural and regulatory elements of the interaction between amyloid-β protein precursor and Homer3. J Alzheimers Dis. 2015;45:147-57 pubmed publisher
    ..Herein, we studied the structural parameters of AβPP/Homer3 interaction by analyzing the sequences and domains that play a role in the formation of the complex...
  6. Jing X, Chen S, Jing W, Tan Q, Yu M, Tu J. Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in coronary artery disease. Int J Mol Sci. 2014;16:535-46 pubmed publisher
    ..The gene expression of Homer1, Homer2, Homer3, IL-1β, and TNF-α in the peripheral blood leukocytes were measured by real-time polymerase chain reaction...
  7. Mansouri M, Kasugai Y, Fukazawa Y, Bertaso F, Raynaud F, Perroy J, et al. Distinct subsynaptic localization of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar cortex. Eur J Neurosci. 2015;41:157-67 pubmed publisher
    ..Although Homer proteins are known to interact with the mGlu1 receptor C-terminus, we could not detect Homer3, the most abundant Homer protein in the cerebellar cortex, at GABAergic synapses by pre-embedding and post-..
  8. Chen S, Zhang Y, Wang H, Zeng Y, Li Z, Li M, et al. WW domain-binding protein 2 acts as an oncogene by modulating the activity of the glycolytic enzyme ENO1 in glioma. Cell Death Dis. 2018;9:347 pubmed publisher
    ..MS/GST pulldown assay identified α-enolase (ENO1) and Homer protein homolog 3 (Homer3) as novel potent interaction partners of WBP2...
  9. du Jardin K, Müller H, Sanchez C, Wegener G, Elfving B. A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex. Eur J Pharmacol. 2016;786:29-35 pubmed publisher
    ..The main finding was that vortioxetine enhanced plasticity-related gene expression (Mtor, Mglur1, Pkc?, Homer3, Spinophilin, and Synapsin3) in the frontal cortex at 8h after a single dose...

More Information


  1. Zhu M, Zuo J, Shen J, Jing W, Luo P, Li N, et al. Diagnostic Potential of Differentially Expressed Homer1 and Homer2 in Ischemic Stroke. Cell Physiol Biochem. 2016;39:2353-2363 pubmed
    ..RT-qPCR was performed to detect the expression of Homer1, Homer2, and Homer3. We found that the mRNA levels of Homer1 (p<0.001) and Homer2 (p<0...
  2. Jarius S, Metz I, König F, Ruprecht K, Reindl M, Paul F, et al. Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in 'pattern II multiple sclerosis' and brain biopsy findings in a MOG-IgG-positive case. Mult Scler. 2016;22:1541-1549 pubmed
    ..anti-Ca/RhoGTPase-activating protein 26 (ARHGAP26), anti-Sj/inositol-1,4,5-trisphosphate receptor 1 (ITPR1), anti-Homer3, anti-carbonic anhydrase-related protein (CARPVIII), anti-protein kinase gamma (PKCgamma), anti-glutamate receptor ..
  3. Fan P, Cunliffe H, Griffith O, Agboke F, Ramos P, Gray J, et al. Identification of gene regulation patterns underlying both oestrogen- and tamoxifen-stimulated cell growth through global gene expression profiling in breast cancer cells. Eur J Cancer. 2014;50:2877-86 pubmed publisher
    ..4-OHT was more potent than E2 in up-regulating some membrane remodelling molecules, such as EHD2, FHL2, HOMER3 and RHOF...
  4. Ruegsegger C, Stucki D, Steiner S, Angliker N, Radecke J, Keller E, et al. Impaired mTORC1-Dependent Expression of Homer-3 Influences SCA1 Pathophysiology. Neuron. 2016;89:129-46 pubmed publisher
    ..Our work reveals that impaired mTORC1-Homer-3 activity underlies PC susceptibility in SCA1 and presents a promising therapeutic target. ..
  5. Jarius S, Wildemann B. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. J Neuroinflammation. 2015;12:166 pubmed publisher
    ..Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein VIII-..
  6. Feng W, Tu J, Yang T, Vernon P, Allen P, Worley P, et al. Homer regulates gain of ryanodine receptor type 1 channel complex. J Biol Chem. 2002;277:44722-30 pubmed
    ..This form of regulation may be important in other cell types that express Homer and RyR1. ..
  7. Kyratzi E, Efthimiopoulos S. Calcium regulates the interaction of amyloid precursor protein with Homer3 protein. Neurobiol Aging. 2014;35:2053-63 pubmed publisher
    ..In this study, we investigated the effect of Ca(2+) homeostasis alterations on APP/Homer3 interaction...
  8. Scoles D, Meera P, Schneider M, Paul S, Dansithong W, Figueroa K, et al. Antisense oligonucleotide therapy for spinocerebellar ataxia type 2. Nature. 2017;544:362-366 pubmed publisher
    ..protein levels of several SCA2-related proteins expressed in Purkinje cells, including Rgs8, Pcp2, Pcp4, Homer3, Cep76 and Fam107b...
  9. Yatherajam G, Banerjee P, McCorkell K, Solt L, Hanson E, Madge L, et al. Cutting edge: association with I kappa B kinase beta regulates the subcellular localization of Homer3. J Immunol. 2010;185:2665-9 pubmed publisher
    The signaling and adaptor protein Homer3 plays a role in controlling immune homeostasis and self-reactivity...
  10. Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimiopoulos S. Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. Neurobiol Dis. 2008;30:353-64 pubmed publisher
    ..In this study, we provide evidence that Homer2 and Homer3 but not Homer1 proteins interact specifically with APP...
  11. Schreiner D, Müller K, Hofer H. The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. FEBS Lett. 2006;580:5295-300 pubmed
    ..As Homer proteins and Fat1 have been both linked to psychic disorders, their interaction may be of patho-physiological importance. ..
  12. Soloviev M, Ciruela F, Chan W, McIlhinney R. Molecular characterisation of two structurally distinct groups of human homers, generated by extensive alternative splicing. J Mol Biol. 2000;295:1185-200 pubmed
    ..The existence of the long and the short variants of each of the Homer-1, Homer-2 and Homer-3 proteins reflects the fundamental principles of Homer functions. ..
  13. Li Z, Qiu H, Jiao Y, Cen J, Fu C, Hu S, et al. Growth and differentiation effects of Homer3 on a leukemia cell line. Asian Pac J Cancer Prev. 2013;14:2525-8 pubmed
    ..also known as the family of cytoplasmic scaffolding proteins, which include three subtypes (Homer1, Homer2, Homer3)...
  14. Rezvani K, Baalman K, Teng Y, Mee M, Dawson S, Wang H, et al. Proteasomal degradation of the metabotropic glutamate receptor 1? is mediated by Homer-3 via the proteasomal S8 ATPase: Signal transduction and synaptic transmission. J Neurochem. 2012;122:24-37 pubmed publisher
    ..These results suggest that long Homer-3 proteins control the degradation of mGluR1? receptors by shuttling ubiquitinated mGluR-1? receptors to the 26S proteasome via the S8 ATPase which may modulate synaptic transmission. ..
  15. Hayashi M, Tang C, Verpelli C, Narayanan R, Stearns M, Xu R, et al. The postsynaptic density proteins Homer and Shank form a polymeric network structure. Cell. 2009;137:159-71 pubmed publisher
    ..We propose that the Homer-Shank complex serves as a structural framework and as an assembly platform for other PSD proteins. ..
  16. Cooper S, Hanson I. A screen for proteins that interact with PAX6: C-terminal mutations disrupt interaction with HOMER3, DNCL1 and TRIM11. BMC Genet. 2005;6:43 pubmed
    ..Three novel PAX6-interacting proteins were identified: the post-synaptic density (PSD) protein HOMER3, the dynein subunit DNCL1, and the tripartite motif protein TRIM11...
  17. Ishiguro K, Xavier R. Homer-3 regulates activation of serum response element in T cells via its EVH1 domain. Blood. 2004;103:2248-56 pubmed
    ..These findings suggest that Homer-3 may be involved in the regulation of SRE activation in T cells via interaction between its EVH1 domain and C/EBP beta. ..
  18. Yuan J, Kiselyov K, Shin D, Chen J, Shcheynikov N, Kang S, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003;114:777-89 pubmed
    ..Since H1a is transcriptionally regulated by cellular activity, this mechanism can affect both short and long-term regulation of TRPC1 function. ..
  19. Norton N, Williams H, Williams N, Spurlock G, Zammit S, Jones G, et al. Mutation screening of the Homer gene family and association analysis in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003;120B:18-21 pubmed
    ..05). Our results suggest it is unlikely that sequence variants in the Homer genes contribute to the aetiology of schizophrenia, but the variants we identified are plausible candidates for other neuropsychiatric phenotypes. ..
  20. Brakeman P, Lanahan A, O Brien R, Roche K, Barnes C, Huganir R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997;386:284-8 pubmed
    ..This dynamic transcriptional control suggests that Homer mediates a novel cellular mechanism that regulates metabotropic glutamate signalling. ..
  21. Wu J, Pipathsouk A, Keizer Gunnink A, Fusetti F, Alkema W, Liu S, et al. Homer3 regulates the establishment of neutrophil polarity. Mol Biol Cell. 2015;26:1629-39 pubmed publisher
    ..Through affinity chromatography using primary neutrophil lysate, we identify Homer3 as a novel Gαi2-binding protein...