HOMER2

Summary

Gene Symbol: HOMER2
Description: homer scaffold protein 2
Alias: ACPD, CPD, DFNA68, HOMER-2, VESL-2, homer protein homolog 2, cupidin, homer homolog 2, homer homolog 3, homer scaffolding protein 2, homer, neuronal immediate early gene, 2
Species: human
Products:     HOMER2

Top Publications

  1. Hufbauer M, Cooke J, van der Horst G, Pfister H, Storey A, Akgül B. Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis. Mol Cancer. 2015;14:183 pubmed publisher
    ..driven skin tumorigenesis by crossing K14-HPV8-E6wt mice (developing skin tumors after UV treatment) with K14-CPD-photolyase animals and by generating the K14-HPV8-E6-K136N mutant mouse strain...
  2. Nucci Martins C, Martins D, Nascimento L, Venzke D, Oliveira A, Frederico M, et al. Ameliorative potential of standardized fruit extract of Pterodon pubescens Benth on neuropathic pain in mice: Evidence for the mechanisms of action. J Ethnopharmacol. 2015;175:273-86 pubmed publisher
    ..t.) of ionotropic (AMPA, NMDA and kainate) and metabotropic (trans-ACPD) glutamate receptor agonists, proinflammatory cytokines such as IL-1β and TNF-α, as well as TRPV1 and TRPA1 ..
  3. Guerrero Ramos E, Cordero J, Molina González D, Poeta P, Igrejas G, Alonso Calleja C, et al. Antimicrobial resistance and virulence genes in enterococci from wild game meat in Spain. Food Microbiol. 2016;53:156-64 pubmed publisher
    ..8% of the tet(M)-positive enterococci. Nine virulence factors (gelE, agg, ace, cpd, frs, esp, hyl, efaAfs and efaAfm) were studied...
  4. Allareddy V, Martinez Schlurmann N, Rampa S, Nalliah R, Lidsky K, Allareddy V, et al. Predictors of Complications of Tonsillectomy With or Without Adenoidectomy in Hospitalized Children and Adolescents in the United States, 2001-2010: A Population-Based Study. Clin Pediatr (Phila). 2016;55:593-602 pubmed publisher
    ..3%). Frequently present CMC in patients included obstructive sleep apnea (OSA, 26.4%), chronic pulmonary disease (CPD, 14.6%), neurological disorders (ND, 6.7%), and obesity (4.8%)...
  5. Gavin H, Beubier N, Satchell K. The Effector Domain Region of the Vibrio vulnificus MARTX Toxin Confers Biphasic Epithelial Barrier Disruption and Is Essential for Systemic Spread from the Intestine. PLoS Pathog. 2017;13:e1006119 pubmed publisher
    ..Upon inositol hexakisphosphate-induced activation of the of the MARTX cysteine protease domain (CPD) in the eukaryotic cytosol, effector domains are released from the holotoxin by autoproteolytic activity...
  6. Fassaert L, de Borst G. Technical improvements in carotid revascularization based on the mechanism of procedural stroke. J Cardiovasc Surg (Torino). 2019;: pubmed publisher
    ..Stent design and cerebral protection devices (CPD) for CAS procedure are continuously under development...
  7. Schuliga M, Royce S, Langenbach S, Berhan A, Harris T, Keenan C, et al. The Coagulant Factor Xa Induces Protease-Activated Receptor-1 and Annexin A2-Dependent Airway Smooth Muscle Cytokine Production and Cell Proliferation. Am J Respir Cell Mol Biol. 2016;54:200-9 pubmed publisher
    ..hirudin (1 U/ml), a selective thrombin inhibitor, but were attenuated by SCH79797 (100 nM), a PAR-1 antagonist, or Cpd 22 (1 μM), an inhibitor of integrin-linked kinase...
  8. Piro J, Suidan G, Quan J, Pi Y, O Neill S, Ilardi M, et al. Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury. J Neuroinflammation. 2018;15:142 pubmed publisher
    ..ischemic insult, respectively, in the presence and absence of the monoacylglycerol lipase (MAGL) inhibitor, CPD-4645...
  9. Yu S, Tang S, Mayer G, Cobb G, Maul J. Interactive effects of ultraviolet-B radiation and pesticide exposure on DNA photo-adduct accumulation and expression of DNA damage and repair genes in Xenopus laevis embryos. Aquat Toxicol. 2015;159:256-66 pubmed publisher
    ..Each of the co-exposure scenarios resulted in elevated CPD levels compared to UVB exposure alone, suggesting an inhibitory effect of endosulfan and α-cypermethrin on CPD ..

More Information

Publications145 found, 100 shown here

  1. Dai W, Zhou F, Wei C, Wang X, Guo S, Yi X, et al. A functional single-nucleotide polymorphism in the ERCC1 gene alters the efficacy of narrowband ultraviolet B therapy in patients with active vitiligo in a Chinese population. Br J Dermatol. 2015;173:457-63 pubmed publisher
    ..Furthermore, we examined the impact of ERCC1 C118T on the apoptosis of T lymphocytes and CPD accumulation after NB-UVB irradiation...
  2. Cozzoli D, Kaufman M, Nipper M, Hashimoto J, Wiren K, Finn D. Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice. Neuropharmacology. 2016;105:164-174 pubmed publisher
    ..Expression of genes encoding mGlu1, mGlu5, the NR2A subunit of the NMDA receptor, and Homer2 were all decreased by binge alcohol consumption in males, while females were relatively resistant (only ..
  3. Kubašová I, Strompfová V, Lauková A. Safety assessment of commensal enterococci from dogs. Folia Microbiol (Praha). 2017;62:491-498 pubmed publisher
    ..most frequently detected were genes encoding adhesins efa Afm and efa Afs and sex pheromone cpd. IS16 gene, a marker specific for hospital strains, appeared in nine E. faecium strains...
  4. Divya S, Wang X, Pratheeshkumar P, Son Y, Roy R, Kim D, et al. Blackberry extract inhibits UVB-induced oxidative damage and inflammation through MAP kinases and NF-κB signaling pathways in SKH-1 mice skin. Toxicol Appl Pharmacol. 2015;284:92-99 pubmed publisher
    ..of BBE inhibited the expression of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG), cyclobutane pyrimidine dimers (CPD), proliferating cell nuclear antigen (PCNA), and cyclin D1 in UVB-exposed skin...
  5. Solé M, Panteli D, Risso Gill I, Döring N, Busse R, McKee M, et al. How do medical doctors in the European Union demonstrate that they continue to meet criteria for registration and licencing?. Clin Med (Lond). 2014;14:633-9 pubmed publisher
    ..including their roles and functions; the processes involved, including continuing professional development (CPD) and/or continuing medical education (CME); and contextual factors, particularly those impacting professional ..
  6. Schaefer F, Benner L, Borzych Dużałka D, Zaritsky J, Xu H, Rees L, et al. Global Variation of Nutritional Status in Children Undergoing Chronic Peritoneal Dialysis: A Longitudinal Study of the International Pediatric Peritoneal Dialysis Network. Sci Rep. 2019;9:4886 pubmed publisher
    ..We sought to investigate the variation of nutritional status in children undergoing chronic peritoneal dialysis (CPD) around the globe...
  7. Nakajima T, Kitagawa K, Ohhata T, Sakai S, Uchida C, Shibata K, et al. Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2. J Biol Chem. 2015;290:10368-81 pubmed publisher
    ..GATA2 contains a cell division control protein 4 (Cdc4) phosphodegron (CPD), a consensus motif for ubiquitylation by Fbw7, which includes Thr(176)...
  8. Afroz S, Garg R, Fodje M, van Drunen Littel van den Hurk S. The Major Tegument Protein of Bovine Herpesvirus 1, VP8, Interacts with DNA Damage Response Proteins and Induces Apoptosis. J Virol. 2018;92: pubmed publisher
    ..Furthermore, UV light-induced cyclobutane pyrimidine dimer (CPD) repair was reduced in the presence of VP8, and VP8 in fact enhanced etoposide or UV-induced apoptosis...
  9. Biswas K, Sharma P, Joshi S. Co-occurrence of antimicrobial resistance and virulence determinants in enterococci isolated from traditionally fermented fish products. J Glob Antimicrob Resist. 2018;17:79-83 pubmed publisher
    ..The presence of virulence genes (gelE, agg, esp, cpd, efaAfs and cylA) was investigated by PCR. gelE, agg and esp were present in 17, 13 and 4 isolates, respectively...
  10. Narita K, Asano K, Morimoto Y, Igarashi T, Hamblin M, Dai T, et al. Disinfection and healing effects of 222-nm UVC light on methicillin-resistant Staphylococcus aureus infection in mouse wounds. J Photochem Photobiol B. 2018;178:10-18 pubmed publisher
    ..However, exposure to 254-nm-UVC light causes DNA lesions such as cyclobutane pyrimidine dimers (CPD) in human cells, and can induce skin cancer after long-term repeated exposures...
  11. Campbell R, Domingo R, Williams A, Wroten M, McGregor H, Waltermire R, et al. Increased Alcohol-Drinking Induced by Manipulations of mGlu5 Phosphorylation within the Bed Nucleus of the Stria Terminalis. J Neurosci. 2019;39:2745-2761 pubmed publisher
    ..in male mice, a history of chronic binge alcohol-drinking elevates BNST levels of the mGlu5-scaffolding protein Homer2 and activated extracellular signal-regulated kinase (ERK) in an adaptive response to limit alcohol consumption...
  12. Kumar P, Mauriello C, Hair P, Rister N, Lawrence C, Raafat R, et al. Glucose-based dialysis fluids inhibit innate defense against Staphylococcus aureus. Mol Immunol. 2015;67:575-83 pubmed publisher
    Staphylococcus aureus peritonitis is a serious complication of Chronic Peritoneal Dialysis (CPD) and associated with a higher risk for severe and recurrent infections compared with other bacteria...
  13. Huang Y, Wang X, Niu X, Wang X, Jiang R, Xu T, et al. EZH2 suppresses the nucleotide excision repair in nasopharyngeal carcinoma by silencing XPA gene. Mol Carcinog. 2017;56:447-463 pubmed publisher
    ..cell lines, increased XPA expression by EZH2 inhibition resulted in a more rapid removal of UVC induced 6-4PP- and CPD-DNA adducts, as well as enhanced efficiency of DNA repair after UVC irradiation as detected by the Comet assay and ..
  14. Guan L, Suggs A, Galan E, Lam M, Baron E. Topical application of ST266 reduces UV-induced skin damage. Clin Cosmet Investig Dermatol. 2017;10:459-471 pubmed publisher
    ..in vivo effects of ST266 on post UV-irradiated skin by measuring erythema, level of cyclobutane pyrimidine dimer (CPD), and expression level of xeroderma pigmentosum, complementation group A (XPA)...
  15. Fan T, Sun G, Zhao L, Cui X, Zhong R. Metabolic Activation and Carcinogenesis of Tobacco-Specific Nitrosamine N'-Nitrosonornicotine (NNN): A Density Function Theory and Molecular Docking Study. Int J Environ Res Public Health. 2019;16: pubmed publisher
    ..The results indicated that NNN catalyzed by the ferric porphyrin (Compound I, Cpd I) at the active center of CYP450 included two steps, hydrogen abstraction and rebound reactions...
  16. Bailey H, Lacour B, Guerrini Rousseau L, Bertozzi A, Leblond P, Faure Conter C, et al. Parental smoking, maternal alcohol, coffee and tea consumption and the risk of childhood brain tumours: the ESTELLE and ESCALE studies (SFCE, France). Cancer Causes Control. 2017;28:719-732 pubmed publisher
    ..25 (95% CI 1.03, 1.52) with an OR of 1.09 (0.99, 1.19) for every 10 cigarettes per day (CPD) smoked...
  17. Serna Galvis E, Ferraro F, Silva Agredo J, Torres Palma R. Degradation of highly consumed fluoroquinolones, penicillins and cephalosporins in distilled water and simulated hospital wastewater by UV254 and UV254/persulfate processes. Water Res. 2017;122:128-138 pubmed publisher
    ..ampicillin "AMP", oxacillin "OXA" and cloxacillin "CLO"), two cephalosporins (cephalexin "CPX" and cephadroxyl "CPD") and three fluoroquinolones (levofloxacin "LEV", norfloxacin "NOR" and ciprofloxacin "CIP") were initially treated ..
  18. Han C, Srivastava A, Cui T, Wang Q, Wani A. Differential DNA lesion formation and repair in heterochromatin and euchromatin. Carcinogenesis. 2016;37:129-38 pubmed publisher
    ..g. ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPD) and the pyrimidine (6-4) pyrimidone photoproducts (6-4PP), as well as cisplatin-induced intrastrand crosslinks (Pt-..
  19. Guan L, Suggs A, Ahsanuddin S, Tarrillion M, Selph J, Lam M, et al. 2016 Arte Poster Competition First Place Winner: Circadian Rhythm and UV-Induced Skin Damage: An In Vivo Study. J Drugs Dermatol. 2016;15:1124-30 pubmed
    ..to DNA damage, such as xeroderma pigmentosum, complementation group A (XPA), and cyclobutane pyrimidine dimers (CPD) from skin biopsies correlated with our clinical results...
  20. Park S, Murphy S, Wilkens L, Stram D, Hecht S, Le Marchand L. Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study. PLoS ONE. 2017;12:e0178435 pubmed publisher
    ..002). The association for CYP2A6 activity remained even after adjusting for self-reported cigarettes per day (CPD) (Hazard Ratio [HR] per unit increase in log-CYP2A6 activity = 1.52; p = 0.005) and after adjusting for TNE (HR = 1...
  21. Ferrucio B, Tiago M, Fannin R, Liu L, Gerrish K, Maria Engler S, et al. Molecular effects of 1-naphthyl-methylcarbamate and solar radiation exposures on human melanocytes. Toxicol In Vitro. 2017;38:67-76 pubmed publisher
    ..S-phase cell cycle arrest, reduced apoptosis levels and faster induction of cyclobutane pyrimidine dimers (CPD) lesions in carbaryl treated groups...
  22. Marizcurrena J, Morel M, Braña V, Morales D, Martínez López W, Castro Sowinski S. Searching for novel photolyases in UVC-resistant Antarctic bacteria. Extremophiles. 2017;21:409-418 pubmed publisher
    ..has serious consequences for cell survival, including DNA damage by formation of cyclobutane pyrimidine dimers (CPD) and pyrimidine (6,4) pyrimidone photoproducts...
  23. Tagua V, Pausch M, Eckel M, Gutiérrez G, Miralles Durán A, Sanz C, et al. Fungal cryptochrome with DNA repair activity reveals an early stage in cryptochrome evolution. Proc Natl Acad Sci U S A. 2015;112:15130-5 pubmed publisher
    ..considered as sensory photoreceptors because of their incapability to repair cyclobutane pyrimidine dimer (CPD) lesions in duplex DNA...
  24. Goyal S, Amar S, Dubey D, Pal M, Singh J, Verma A, et al. Involvement of cathepsin B in mitochondrial apoptosis by p-phenylenediamine under ambient UV radiation. J Hazard Mater. 2015;300:415-425 pubmed publisher
    ..It caused an oxidative DNA damage via single stranded DNA breaks, micronuclei and CPD formation...
  25. Zhang X, Rao W, Yu Q, Yu Y, Kou C, Tan Y, et al. Association of the manganese superoxide dismutase gene Ala-9Val polymorphism with age of smoking initiation in male schizophrenia smokers. Am J Med Genet B Neuropsychiatr Genet. 2016;171B:243-9 pubmed publisher
    ..The cigarettes smoked per day (CPD) and smoking behaviors were evaluated by clinician-administered questionnaires and the Fagerstrom Test for Nicotine ..
  26. Kong J, Whelan K, Laczkó D, Dang B, Caro Monroig A, Soroush A, et al. Autophagy levels are elevated in barrett's esophagus and promote cell survival from acid and oxidative stress. Mol Carcinog. 2016;55:1526-1541 pubmed publisher
    ..a functional role for autophagy in BE pathogenesis, normal squamous (STR), non-dysplastic BE (CPA), dysplastic BE (CPD), and EAC (OE19) cell lines were exposed to an acid pulse (pH 3...
  27. Meyers J, Salling M, Almli L, Ratanatharathorn A, Uddin M, Galea S, et al. Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways. Transl Psychiatry. 2015;5:e586 pubmed publisher
    ..83% African American), 206 genetic variants across the mGluR-eEF2-AMPAR pathway (including GRM1, GRM5, HOMER1, HOMER2, EEF2K, MTOR, EIF4E, EEF2, CAMK2A, ARC, GRIA1 and GRIA4) were found to predict number of drinking days per month (..
  28. Marizcurrena J, Martínez López W, Ma H, Lamparter T, Castro Sowinski S. A highly efficient and cost-effective recombinant production of a bacterial photolyase from the Antarctic isolate Hymenobacter sp. UV11. Extremophiles. 2019;23:49-57 pubmed publisher
    ..This CPD-photolyase was fully active on CHO and HaCat cell lines, suggesting that this enzyme could be used for medical or ..
  29. Cozzoli D, Courson J, Rostock C, Campbell R, Wroten M, McGregor H, et al. Protein Kinase C Epsilon Activity in the Nucleus Accumbens and Central Nucleus of the Amygdala Mediates Binge Alcohol Consumption. Biol Psychiatry. 2016;79:443-51 pubmed publisher
    ..regions reduced binge alcohol consumption in a manner requiring intact group 1 metabotropic glutamate receptors, Homer2, phospholipase C, and/or phosphotidylinositide-3 kinase function...
  30. Castrillo M, Bernhardt A, Ávalos J, Batschauer A, Pokorny R. Biochemical Characterization of the DASH-Type Cryptochrome CryD From Fusarium fujikuroi. Photochem Photobiol. 2015;91:1356-67 pubmed publisher
    ..However, most organisms possess conventional CPD photolyases responsible for repair of these lesions in vivo...
  31. Cotti E, Esposito S, Musu D, Campisi G, Shemesh H. Ultrasound examination with color power Doppler to assess the early response of apical periodontitis to the endodontic treatment. Clin Oral Investig. 2018;22:131-140 pubmed publisher
    ..early vascular changes in apical periodontitis (AP) using ultrasound examination with color power Doppler (US-CPD) and to establish a correlation between the early response of AP to treatment and its potential healing...
  32. Berndt A, Murray C, Kennedy K, Stanley M, Gilbert Hunt S. Effectiveness of distance learning strategies for continuing professional development (CPD) for rural allied health practitioners: a systematic review. BMC Med Educ. 2017;17:117 pubmed publisher
    ..Registration with PROSPERO 30 June 2016: CRD42016041588 . ..
  33. Haider A, Woodward N, Lominac K, Sacramento A, Klugmann M, Bell R, et al. Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats. Alcohol. 2015;49:533-42 pubmed publisher
    In murine models of alcoholism, the glutamate receptor scaffolding protein Homer2 bidirectionally regulates alcohol intake...
  34. Akram M, Shin I, Kim K, Noh D, Baek S, Chang S, et al. A newly synthesized macakurzin C-derivative attenuates acute and chronic skin inflammation: The Nrf2/heme oxygenase signaling as a potential target. Toxicol Appl Pharmacol. 2016;307:62-71 pubmed publisher
    ..macakurzin C, and identified in vitro and in vivo efficacy of a potent anti-inflammatory flavonoid, Compound 14 (CPD 14), with its underlying mechanisms...
  35. Bergamin L, Figueiró F, Dietrich F, Manica F, Filippi Chiela E, Mendes F, et al. Interference of ursolic acid treatment with glioma growth: An in vitro and in vivo study. Eur J Pharmacol. 2017;811:268-275 pubmed publisher
    ..was verified by Western blot and the long-lasting actions of UA were measured by cumulative population doubling (CPD)...
  36. Shuryak I, Dadachova E. New Approaches for Modeling Radiopharmaceutical Pharmacokinetics Using Continuous Distributions of Rates. J Nucl Med. 2015;56:1622-8 pubmed publisher
    ..We hypothesized that pharmacokinetic processes can be modeled even better by continuous probability distributions (CPD) of rates, using only 1-2 parameters...
  37. Ryzhova I, Nozdrachev A, Tobias T, Orlov I, Chikhman V, Solnushkin S. Metabotropic glutamate receptors as targets of neuromodulatory influence of nitric oxide. Dokl Biol Sci. 2016;469:149-51 pubmed publisher
    ..The modification of the amplitude of responses of metabotropic glutamate receptor agonist trans-ACPD was analyzed during bath applied NO donor S-nitroso-N-acetyl-DL-penicillamine SNAP (0...
  38. Shafiee A, McCune M, Forgacs G, Kosztin I. Post-deposition bioink self-assembly: a quantitative study. Biofabrication. 2015;7:045005 pubmed publisher
    ..We have demonstrated the predictive power of CPD in cases of simple printed constructs prepared with spherical multicellular bioink units...
  39. Aira Z, Barrenetxea T, Buesa I, Martínez E, Azkue J. Spinal D1-like dopamine receptors modulate NMDA receptor-induced hyperexcitability and NR1 subunit phosphorylation at serine 889. Neurosci Lett. 2016;618:152-158 pubmed publisher
    ..Spinal superfusion with selective NMDAR agonist cis-ACPD significantly increased C-fiber-evoked field potentials in rats subjected to spinal nerve ligation (SNL), but not ..
  40. Kanturski M, Karcz J, Wieczorek K. Morphology of the European species of the aphid genus Eulachnus (Hemiptera: Aphididae: Lachninae) - A SEM comparative and integrative study. Micron. 2015;76:23-36 pubmed publisher
    ..FE-SEM images based on HMDS and cryo-SEM preparation techniques revealed better image quality than the CPD technique in regard to surface tension and morphological signs of cell deteriorations (i.e...
  41. Lee T, Cha S, Lee C, Rhee J, Woo H, Chung K. Cross-protection against Vibrio cholerae infection by monoclonal antibodies against Vibrio vulnificus RtxA1/MARTXVv. Microbiol Immunol. 2016;60:793-800 pubmed publisher
    ..cholerae MARTXVc , inhibited CPD autocleavage in vitro; this process is involved in V. cholerae pathogenesis...
  42. McKernon S, Kaura L, Taylor K, Reid S, Balmer M. An Update on Current Resuscitation Council (UK) Guidelines. Dent Update. 2017;44:341-2, 345-6, 349-50 pubmed
    ..The GDC consider medical emergencies as a highly recommended topic for Continuing Professional Development (CPD) and recommend at least 10 hours in every CPD cycle...
  43. Koenig H. Differences between depressed patients with heart failure and those with pulmonary disease. Am J Geriatr Psychiatry. 2006;14:211-9 pubmed
    ..objective of this study was to examine differences between depressed medical inpatients with congestive heart failure (CHF) and chronic pulmonary disease (CPD) that could impact the etiology and management of depression in this setting.
  44. Chumbler N, Farrow M, Lapierre L, Franklin J, Haslam D, Haslam D, et al. Clostridium difficile Toxin B causes epithelial cell necrosis through an autoprocessing-independent mechanism. PLoS Pathog. 2012;8:e1003072 pubmed publisher
    ..The mechanism of toxin action includes an autoprocessing event where a cysteine protease domain (CPD) releases a glucosyltransferase domain (GTD) into the cytosol...
  45. Hashmi S, Velasquez M, Yee D, Hui S, Mahoney D, Srivaths L. Pediatric Acquired von Willebrand Syndrome in Cardiopulmonary Disorders: Do Laboratory Abnormalities Predict Bleeding Risk?. J Pediatr Hematol Oncol. 2017;39:121-125 pubmed publisher
    ..acquired von Willebrand syndrome (AVWS) predict bleeding manifestations in patients with cardiopulmonary disorders (CPD)...
  46. Jeayeng S, Wongkajornsilp A, Slominski A, Jirawatnotai S, Sampattavanich S, Panich U. Nrf2 in keratinocytes modulates UVB-induced DNA damage and apoptosis in melanocytes through MAPK signaling. Free Radic Biol Med. 2017;108:918-928 pubmed publisher
    ..showed that co-culture of MC with siNrf2-transfected KC enhanced UVB-mediated cyclobutane pyrimidine dimer (CPD) formation, apoptosis and oxidant formation, together with phosphorylation of ERK, JNK and p38 in MC...
  47. Rong R, Ahn J, Huang H, Nagata E, Kalman D, Kapp J, et al. PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci. 2003;6:1153-61 pubmed
    ..Our findings indicate that this complex mediates the well-known ability of agonists of mGluRI to prevent neuronal apoptosis. ..
  48. Holloway K, Arcus K, Orsborn G. Training needs analysis - The essential first step for continuing professional development design. Nurse Educ Pract. 2018;28:7-12 pubmed publisher
    ..purposeful and effective development of nursing workforce capability through continuing professional development (CPD)...
  49. Tzourio Mazoyer N, Mazoyer B. Variations of planum temporale asymmetries with Heschl's Gyri duplications and association with cognitive abilities: MRI investigation of 428 healthy volunteers. Brain Struct Funct. 2017;222:2711-2726 pubmed publisher
    ..PT area (PTpost), excluding the second Heschl gyrus in case of either complete posterior duplication (CPD) or common stem partial duplication (CSD)...
  50. Li X, Wang Y, Zheng Q, Zhang H. Detoxification of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes: A theoretical investigation. J Inorg Biochem. 2016;154:21-8 pubmed publisher
    ..MPTP-OH), for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mediated by Compound I (Cpd I) of cytochrome P450 are investigated theoretically using hybrid density functional calculations...
  51. Christofides S, Isidoro J, Pesznyák C, Cremers F, Figueira R, van Swol C, et al. The European Federation of Organisations for Medical Physics Policy Statement No. 10.1: Recommended Guidelines on National Schemes for Continuing Professional Development of Medical Physicists. Phys Med. 2016;32:7-11 pubmed publisher
    Continuing Professional Development (CPD) is vital to the medical physics profession if it is to embrace the pace of change occurring in medical practice...
  52. Canturk F, Karaman M, Selby C, Kemp M, Kulaksiz Erkmen G, Hu J, et al. Nucleotide excision repair by dual incisions in plants. Proc Natl Acad Sci U S A. 2016;113:4706-10 pubmed publisher
    ..Genome sequencing has revealed the presence of genes for both CPD and (6-4)PP photolyases, as well as genes for nucleotide excision repair in plants, such as Arabidopsis and rice...
  53. Lee K, Ward K, Rafferty G, Moxham J, Birring S. The Intensity of Voluntary, Induced, and Spontaneous Cough. Chest. 2015;148:1259-1267 pubmed publisher
    ..flow (PCF), expiratory muscle strength (twitch gastric pressure [TwPga]), and cough compression phase duration (CPD). Subjective perception of cough intensity was assessed using a visual analog scale (VAS)...
  54. Ware J, Gandek B, Kulasekaran A, Guyer R. Evaluation of smoking-specific and generic quality of life measures in current and former smokers in Germany and the United States. Health Qual Life Outcomes. 2015;13:128 pubmed publisher
    ..for groups differing in self-reported smoking behavior (current versus former smoker, cigarettes per day (CPD)) and severity of smoking symptoms in both samples and, in the German trial only, clinical parameters of biomarkers ..
  55. Gelayee D, Mekonnen G, Birarra M. Involvement of community pharmacists in continuing professional development (CPD): a baseline survey in Gondar, Northwest Ethiopia. Global Health. 2018;14:15 pubmed publisher
    ..05 taken as statistically significant. The majority (n = 26, 56.5%) reported of being unaware of the CPD concept. The mean hour spent per week on CPD is 4.1 ± 4.0. Most (n = 34, 73...
  56. Franke A, van Eldik R. Spectroscopic and Kinetic Evidence for the Crucial Role of Compound 0 in the P450cam -Catalyzed Hydroxylation of Camphor by Hydrogen Peroxide. Chemistry. 2015;21:15201-10 pubmed publisher
    The hydroperoxo iron(III) intermediate P450cam Fe(III) -OOH, being the true Compound 0 (Cpd 0) involved in the natural catalytic cycle of P450cam , could be transiently observed in the peroxo-shunt oxidation of the ..
  57. Diamantouros A, Marchesano R, Geerts W, Pennefather P, Zwarenstein M, Austin Z. Development and evaluation of a continuing pharmacy education (CPE) program in thrombosis management. Curr Pharm Teach Learn. 2017;9:911-917 pubmed publisher
    ..in thrombosis management for pharmacists was developed through the Office of Continuing Professional Development (CPD) at the University of Toronto to address pharmacists' needs for the knowledge and skills to provide care to ..
  58. Ikehata H, Mori T, Douki T, Cadet J, Yamamoto M. Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC. Photochem Photobiol Sci. 2018;17:404-413 pubmed publisher
    ..estimate that cannot be used for comparisons between different photolesions such as cyclobutane pyrimidine dimer (CPD) and pyrimidine(6-4)pyrimidone photoproduct (64PP) or for analysis of the genotoxicity of photolesions on a ..
  59. Wang Q, Kamiyama C, Hidema J, Hikosaka K. Ultraviolet-B-induced DNA damage and ultraviolet-B tolerance mechanisms in species with different functional groups coexisting in subalpine moorlands. Oecologia. 2016;181:1069-82 pubmed publisher
    ..We collected current-year leaves in July and August, and determined accumulation of cyclobutane pyrimidine dimer (CPD) as UV-B damage and photorepair activity (PRA) and concentrations of UV-absorbing compounds (UACs) and carotenoids (..
  60. Konti A, Mamma D, Hatzinikolaou D, Kekos D. 3-Chloro-1,2-propanediol biodegradation by Ca-alginate immobilized Pseudomonas putida DSM 437 cells applying different processes: mass transfer effects. Bioprocess Biosyst Eng. 2016;39:1597-609 pubmed publisher
    3-Chloro-1,2-propanediol (3-CPD) biodegradation by Ca-alginate immobilized Pseudomonas putida cells was performed in batch system, continuous stirred tank reactor (CSTR), and packed-bed reactor (PBR)...
  61. Mack H, Meng N, Parsons T, Schlenther G, Murray N, Hart R. Partnering to develop a continuing professional development program in a low-resource setting: Cambodia. Can J Ophthalmol. 2017;52:379-384 pubmed publisher
    To design and implement a continuing professional development (CPD) program for Cambodian ophthalmologists...
  62. Yu S, Wang F, Tan X, Gao G, Pan W, Luan Y, et al. FBW7 targets KLF10 for ubiquitin-dependent degradation. Biochem Biophys Res Commun. 2018;495:2092-2097 pubmed publisher
    ..E3 ubiquitin ligase, targets various proteins for degradation via the conserved Cdc4 phosphodegron (CPD) in substrates. In this study, we report that KLF10 is degraded by FBW7 via a conserved CPD...
  63. Thiels C, Bergquist J, Laan D, Croome K, Smoot R, Nagorney D, et al. Outcomes of Pancreaticoduodenectomy for Pancreatic Neuroendocrine Tumors: Are Combined Procedures Justified?. J Gastrointest Surg. 2016;20:891-8 pubmed publisher
    ..Patients were categorized into standard PD (SPD) alone or combined PD (CPD) defined as patients undergoing concurrent vascular reconstruction or additional organ resection for curative ..
  64. Shi Y, Pierce J, White M, Vijayaraghavan M, Compton W, Conway K, et al. E-cigarette use and smoking reduction or cessation in the 2010/2011 TUS-CPS longitudinal cohort. BMC Public Health. 2016;16:1105 pubmed
    ..1 % vs 21.6 %; ORadj?=?0.44, 95 % CI?=?0.2-0.8). Among heavier smokers at baseline (15+ cigarettes per day (CPD)), ever-use of e-cigarettes was not associated with change in smoking consumption...
  65. Ganesh S, Brar S, Patel U. Comparison of ReLEx SMILE and PRK in terms of visual and refractive outcomes for the correction of low myopia. Int Ophthalmol. 2018;38:1147-1154 pubmed publisher
    ..SMILE group demonstrated slightly better contrast sensitivity, which was significant at spatial frequency of 12 cpd (p = 0.03). Four eyes in the PRK group had loss of CDVA by one line due to mild haze...
  66. Cohrs K, Schumacher J. The Two Cryptochrome/Photolyase Family Proteins Fulfill Distinct Roles in DNA Photorepair and Regulation of Conidiation in the Gray Mold Fungus Botrytis cinerea. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..i>B. cinerea CRY1 (BcCRY1), a cyclobutane pyrimidine dimer (CPD) photolyase, acts as the major enzyme of light-driven DNA repair (photoreactivation) and has no obvious role in ..
  67. Patel K, Terán D, Zheng S, Kandale A, Garcia M, Lv Y, et al. Crystal structures of Staphylococcus aureus ketol-acid reductoisomerase in complex with two transition state analogs that have biocidal activity. Chemistry. 2017;: pubmed publisher
    ..aureus (Sa) KARI, these in complex with two transition state analogs, cyclopropane-1,1-dicarboxylate (CPD) and N-isopropyloxalyl hydroxamate (IpOHA)...
  68. Lanlehin R. Self-tracking, governmentality, and Nursing and Midwifery Council's (2016) revalidation policy. Nurse Educ Today. 2018;64:125-129 pubmed publisher
    ..2016 the Nursing and Midwifery Council (NMC) introduced a new revalidation continuous professional development (CPD) policy...
  69. CreŢu O, Hut E, Dan R, Sima L, Blidişel C, Lighezan D, et al. Modified Whipple-Child pancreaticoduodenectomy with anastomosis on jejunal loop in continuity. Presentation of surgical technique and preliminary observations on 45 patients. Rom J Morphol Embryol. 2017;58:1295-1299 pubmed
    Cephalic pancreaticoduodenectomy (CPD) is the only current treatment method that can provide long-term survival in patients with periampullary tumors...
  70. Mills J, Francis K, McLeod M, Al Motlaq M. Enhancing computer literacy and information retrieval skills: A rural and remote nursing and midwifery workforce study. Collegian. 2015;22:283-9 pubmed
    ..It examines the impact of an online continuing professional development (CPD) program on Australian rural nurses and midwives...
  71. Mack H, Sandhu S, Filipe H. Developing educators for continuing professional development. Can J Ophthalmol. 2016;51:196-200 pubmed publisher
    Continuing professional development (CPD) is part of the medical education continuum, has been shown to produce improved physician practice and good patient outcomes, and is increasingly required for revalidation of medical licensure...
  72. Zhang M, Wang L, Shu S, Sancar A, Zhong D. Bifurcating electron-transfer pathways in DNA photolyases determine the repair quantum yield. Science. 2016;354:209-213 pubmed
    ..femtosecond spectroscopy to deconvolute seven electron-transfer reactions in 10 elementary steps in all classes of CPD photolyases...
  73. Gao Y, Gui G, Xie W, Zou Y, Yang Y, Wan Q. A Type-2 Block-Component-Decomposition Based 2D AOA Estimation Algorithm for an Electromagnetic Vector Sensor Array. Sensors (Basel). 2017;17: pubmed publisher
    ..Even under the conditions of lower SNR, small angular separation and limited snapshots, the proposed algorithm still possesses better performance than subspace methods and the canonical polyadic decomposition (CPD) method.
  74. Cheng J, Guan Y, Zhang Y, Bi Y, Bu L, Li Y, et al. Electrophysiological mechanisms of biased response to smoking-related cues in young smokers. Neurosci Lett. 2016;629:85-91 pubmed publisher
    ..Meanwhile, a positive correlation between Cigarette Per Day (CPD) and the amplitude of ERPs wave (P300/SPW) at anterior (Fz), central (Cz) were observed in young adult smokers...
  75. Lian H, Du Y, Chen X, Duan L, Gao G, Xiao C, et al. Core cross-linked poly(ethylene glycol)-graft-Dextran nanoparticles for reduction and pH dual responsive intracellular drug delivery. J Colloid Interface Sci. 2017;496:201-210 pubmed publisher
    A kind of core cross-linked poly(ethylene glycol)-graft-Dextran nanoparticles (CPD NPs) was prepared by a simple chemical cross-linking method for reduction and pH dual response drug delivery...
  76. Kim N, Stagnell S. Postgraduate education in dental implantology in the United Kingdom: a review. Int J Implant Dent. 2018;4:8 pubmed publisher
    ..This study aims to identify UK postgraduate academic qualifications and continuing professional development (CPD) courses available in the field of Dental Implantology and evaluates the current standard of the postgraduate ..
  77. Kozlova Ð, Chernysh Ð, Moroz V, Sergunova V, Gudkova Ð, Kuzovlev Ð. Nanodefects of membranes cause destruction of packed red blood cells during long-term storage. Exp Cell Res. 2015;337:192-201 pubmed publisher
    ..PRBC were stored for 30 days under 4 °С in hermetic blood bags with CPD anticoagulant-preservative solution. Hematocrit was 50-55%...
  78. Kidd E, Fejerskov O, Nyvad B. Infected Dentine Revisited. Dent Update. 2015;42:802-6, 808-9 pubmed
    ..Thus complete excavation'is not needed and should be avoided. CPD/CLINICAL RELEVANCE: Root surface caries can be arrested by cleaning and fluoride application...
  79. Li J, Li C, Cichocki A. Canonical Polyadic Decomposition With Auxiliary Information for Brain-Computer Interface. IEEE J Biomed Health Inform. 2017;21:263-271 pubmed publisher
    ..Unlike vector-based methods that destroy data structure, canonical polyadic decomposition (CPD) aims to process physiological signals in the form of multiway array, which considers relationships between ..
  80. Zaheer K, Langguth P. Formulation strategy towards minimizing viscosity mediated negative food effect on disintegration and dissolution of immediate release tablets. Drug Dev Ind Pharm. 2018;44:444-451 pubmed publisher
    ..In this study, three super disintegrants, croscarmellose sodium (CCS), cross-linked polyvinylpolypyrrolidone (CPD), and sodium starch glycolate (SSG) were assessed for their efficiency under simulated fed state...
  81. Politowicz J, Lech K, Sánchez Rodríguez L, Szumny A, Carbonell Barrachina A. Volatile composition and sensory profile of Cantharellus cibarius Fr. as affected by drying method. J Sci Food Agric. 2017;97:5223-5232 pubmed publisher
    ..was evaluated. The drying methods tested were convective drying (CD), freeze drying (FD), vacuum microwave drying (VMD) and a combination of convective pre-drying and vacuum microwave finish drying (CPD-VMFD).
  82. Masschaele D, De Ceuninck L, Wauman J, Defever D, Stenner F, Lievens S, et al. RNF41 interacts with the VPS52 subunit of the GARP and EARP complexes. PLoS ONE. 2017;12:e0178132 pubmed publisher
    ..Through interaction via their coiled coil domains, RNF41 ubiquitinates and relocates VPS52 away from VPS53, a common subunit of the GARP and EARP complexes, towards RNF41 bodies. ..
  83. Dela Peña I, Dela Peña I, de la Peña J, Kim H, Shin C, Han D, et al. Methylphenidate and Atomoxetine-Responsive Prefrontal Cortical Genetic Overlaps in "Impulsive" SHR/NCrl and Wistar Rats. Behav Genet. 2017;47:564-580 pubmed publisher
    ..g., Btg2, Fos, Nr4a2), synaptic plasticity (e.g., Arc, Homer2), and neuron apoptosis (Grik2, Nmnat1)...
  84. Mitchell A. Assessing the value of practice-based leg ulcer education to inform recommendations for change in practice. Br J Community Nurs. 2017;22:S28-S34 pubmed publisher
    ..approach of 12 primary care nurses attending the Nurse-Led Assessment and Management of Leg Ulcers accredited CPD module at a London university...
  85. Huang G, Huso D, Bouyain S, Tu J, McCorkell K, May M, et al. NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins. Science. 2008;319:476-81 pubmed publisher
    ..We found that Homer2 and Homer3, members of the Homer family of cytoplasmic scaffolding proteins, are negative regulators of T cell ..
  86. Hu Z, Zhang H, Haley B, Macchi F, Yang F, Misaghi S, et al. Carboxypeptidase D is the only enzyme responsible for antibody C-terminal lysine cleavage in Chinese hamster ovary (CHO) cells. Biotechnol Bioeng. 2016;113:2100-6 pubmed publisher
    ..In this study, five carboxypeptidases, CpD, CpM, CpN, CpB, and CpE, were studied for message RNA (mRNA) expression by qRT-PCR analysis in two most commonly ..
  87. Boros G, Karikó K, Muramatsu H, Miko E, Emri E, Hegedűs C, et al. Transfection of Human Keratinocytes with Nucleoside-Modified mRNA Encoding CPD-Photolyase to Repair DNA Damage. Methods Mol Biol. 2016;1428:219-28 pubmed publisher
    ..Transfection of nucleoside-modified mRNA encoding photolyase leads to accelerated repair of DNA photolesions in human keratinocytes. ..
  88. de Tommaso M, Trotta G, Vecchio E, Ricci K, Siugzdaite R, Stramaglia S. Brain networking analysis in migraine with and without aura. J Headache Pain. 2017;18:98 pubmed publisher
    ..5 and 2.0 cpd as spatial frequency in migraine with aura (MA) and without aura (MO), and to compare these findings with Blood ..
  89. Kasai T, Kouzuma A, Watanabe K. CpdA is involved in amino acid metabolism in Shewanella oneidensis MR-1. Biosci Biotechnol Biochem. 2017;:1-7 pubmed publisher
    Cyclic 3',5'-adenosine monophosphate (cAMP) phosphodiesterase (CPD) is an enzyme that catalyzes the hydrolysis of cAMP, a signaling molecule affecting diverse cellular and metabolic processes in bacteria...
  90. Leube A, Kovats I, Wahl S, Sickenberger W. Axis-free correction of astigmatism using bifocal soft contact lenses. Cont Lens Anterior Eye. 2017;40:394-400 pubmed publisher
    ..6 cpd to 21.3 cpd. Analysis of Sturm's interval revealed a residual astigmatism of DAst=0.73 D...
  91. Ratnayake W, Apostolatos A, Ostrov D, Acevedo Duncan M. Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis. Int J Oncol. 2017;51:1370-1382 pubmed publisher
    ..We have investigated the effects of two novel aPKC inhibitors; 2-acetyl-1,3-cyclopentanedione (ACPD) and 3,4-diaminonaphthalene-2,7-disulfonic acid (DNDA) on cell proliferation, apoptosis, migration and invasion of ..
  92. Terrone G, Pauletti A, Salamone A, Rizzi M, Villa B, Porcu L, et al. Inhibition of monoacylglycerol lipase terminates diazepam-resistant status epilepticus in mice and its effects are potentiated by a ketogenic diet. Epilepsia. 2017;: pubmed publisher
    ..We studied the effect of a potent and selective irreversible MAGL inhibitor, CPD-4645, on SE that was refractory to diazepam, its neuropathologic sequelae, and the mechanism underlying the drug's ..