HOMER2

Summary

Gene Symbol: HOMER2
Description: homer homolog 2 (Drosophila)
Alias: ACPD, CPD, HOMER-2, VESL-2, cupidin, homer homolog 3, homer protein homolog 2, homer, neuronal immediate early gene, 2
Species: human

Top Publications

  1. ncbi Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
    J C Tu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:717-26. 1998
  2. pmc Ionotropic glutamate receptor types leading to adenosine-mediated inhibition of electrically evoked [3H]-noradrenaline release in rabbit brain cortex slices
    I von Kugelgen
    Pharmakologisches Institut, Freiburg, Germany
    Br J Pharmacol 110:1544-50. 1993
  3. pmc Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex
    R Mistry
    Department of Cell Physiology and Pharmacology, University of Leicester, Germany
    Br J Pharmacol 114:797-804. 1995
  4. pmc Modulation of cyclic AMP formation by putative metabotropic receptor agonists
    J Cartmell
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 111:364-9. 1994
  5. pmc Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors
    S Akhondzadeh
    Pharmacology Laboratories, University of Glasgow
    Br J Pharmacol 115:527-33. 1995
  6. pmc A comparison of the effects of selective metabotropic glutamate receptor agonists on synaptically evoked whole cell currents of rat spinal ventral horn neurones in vitro
    C Q Cao
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol
    Br J Pharmacol 115:1469-74. 1995
  7. ncbi Broad-spectrum virus reduction in red cell concentrates using INACTINE PEN110 chemistry
    A Lazo
    V I Technologies, Inc, 134 Coolidge Avenue, Watertown, MA 02472, USA
    Vox Sang 83:313-23. 2002
  8. pmc Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord
    D E Jane
    Department of Pharmacology, School of Medical Sciences, Bristol
    Br J Pharmacol 112:809-16. 1994
  9. doi The prescription of peritoneal dialysis
    Antonios H Tzamaloukas
    Renal Section, Department of Medicine, New Mexico VA Health Care System, 1501 San Pedro, SE, Albuquerque, NM 87108, USA
    Semin Dial 21:250-7. 2008
  10. ncbi Scrotal edema secondary to fluid imbalance in patients on continuous peritoneal dialysis
    Muniru Adeniyi
    Section of Nephrology, Raymond G Murphy VA Medical Center, Albuquerque, New Mexico 87108, USA
    Adv Perit Dial 25:68-71. 2009

Research Grants

  1. FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPES
    P Conn; Fiscal Year: 1993
  2. Prevention of UV-carcinogenesis through DNA repair-dependent immunomodulation
    Hui Xu; Fiscal Year: 2010
  3. EPILEPTOGENESIS IN THE AMYGDALA
    Patricia Shinnick Gallagher; Fiscal Year: 1993
  4. RADIATION INDUCED CELLULAR MUTAGENESIS AND DNA REPAIR
    RICHARD BOCKRATH; Fiscal Year: 2001
  5. DNA PHOTOLESION STRUCTURE-ACTIVITY RELATIONSHIPS
    JOHN STEPHEN ADOLFINO TAYLOR; Fiscal Year: 2010
  6. DNA PHOTOLESION STRUCTURE-ACTIVITY RELATIONSHIPS
    John Stephen Taylor; Fiscal Year: 2007
  7. Repair of Genotoxic Damage in Chromatin
    Altaf A Wani; Fiscal Year: 2010
  8. Repair of Genotoxic Damage in Chromatin
    Altaf Wani; Fiscal Year: 2007
  9. PROCESSING OF UV-INDUCED DNA DAMAGE IN MAMMALIAN CELLS.
    ERIC MOON SHONG TANG; Fiscal Year: 2004
  10. UV DAMAGE, REPAIR AND MUTAGENESIS
    GERD PFEIFER; Fiscal Year: 2003

Detail Information

Publications156 found, 100 shown here

  1. ncbi Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors
    J C Tu
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:717-26. 1998
    ..These studies identify a novel mechanism in calcium signaling and provide evidence that an IEG, whose expression is driven by synaptic activity, can directly modify a specific synaptic function...
  2. pmc Ionotropic glutamate receptor types leading to adenosine-mediated inhibition of electrically evoked [3H]-noradrenaline release in rabbit brain cortex slices
    I von Kugelgen
    Pharmakologisches Institut, Freiburg, Germany
    Br J Pharmacol 110:1544-50. 1993
    ..NMDA; 30-300 microM) but not the metabotropic glutamate receptor agonist, 1-amino-1,3-cyclopentanedicarboxylate (ACPD; 10-100 microM) reduced the electrically evoked overflow of tritium. 3...
  3. pmc Modulation of NMDA effects on agonist-stimulated phosphoinositide turnover by memantine in neonatal rat cerebral cortex
    R Mistry
    Department of Cell Physiology and Pharmacology, University of Leicester, Germany
    Br J Pharmacol 114:797-804. 1995
    ..accumulation in response to a sub-maximal concentration of the metabotropic glutamate receptor agonist, 1S,3R-ACPD (10 microM). 4. The small (approx...
  4. pmc Modulation of cyclic AMP formation by putative metabotropic receptor agonists
    J Cartmell
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 111:364-9. 1994
    ..2. 1-Aminocyclopentane-1S,3R-dicarboxylate (1S,3R-ACPD), L-2-amino-4-phosphonobutanoate (L-AP4) and (2S,3S,4S)-alpha-(carboxycyclopropyl)glycine (L-CCG-I), elicited ..
  5. pmc Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors
    S Akhondzadeh
    Pharmacology Laboratories, University of Glasgow
    Br J Pharmacol 115:527-33. 1995
    ..Similarly, quisqualic acid and (1S, 3R)-aminocyclopentane dicarboxylic acid (ACPD) a selective agonist at metabotropic receptors did not induce LTD or short-term depression, whereas kynurenic acid ..
  6. pmc A comparison of the effects of selective metabotropic glutamate receptor agonists on synaptically evoked whole cell currents of rat spinal ventral horn neurones in vitro
    C Q Cao
    Department of Pharmacology, School of Medical Sciences, University Walk, Bristol
    Br J Pharmacol 115:1469-74. 1995
    ..were depressed reversibly by the metabotropic glutamate agonists 1S3S-1-aminocyclopentane-1,3-dicarboxylate (1S3S-ACPD) (EC50 17.1 microM +/- 0.3 s.e. mean, n = 14) and L-2-amino-4-phosphonobutanoate (L-AP4) (EC50 = 2.19 +/- 0...
  7. ncbi Broad-spectrum virus reduction in red cell concentrates using INACTINE PEN110 chemistry
    A Lazo
    V I Technologies, Inc, 134 Coolidge Avenue, Watertown, MA 02472, USA
    Vox Sang 83:313-23. 2002
    ..The purpose of this study was to characterize the virucidal effectiveness of the INACTINE PEN110 chemistry in full units of RBCC by using a panel of viruses with diverse properties in composition, size and shape...
  8. pmc Actions of two new antagonists showing selectivity for different sub-types of metabotropic glutamate receptor in the neonatal rat spinal cord
    D E Jane
    Department of Pharmacology, School of Medical Sciences, Bristol
    Br J Pharmacol 112:809-16. 1994
    ..has been differentiated from the similar effects produced by (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate ((1S,3R)-ACPD), (1S,3S)-ACPD and (2S,3S,4S)-alpha-(carboxycyclopropyl)glycine (L-CCG-I), and from the postsynaptic motoneuronal ..
  9. doi The prescription of peritoneal dialysis
    Antonios H Tzamaloukas
    Renal Section, Department of Medicine, New Mexico VA Health Care System, 1501 San Pedro, SE, Albuquerque, NM 87108, USA
    Semin Dial 21:250-7. 2008
    ..maintenance of normal extracellular electrolyte composition, the prescription of continuous peritoneal dialysis (CPD) should address four other specific issues: (i) prevention of uremia by achievement of adequate clearance of ..
  10. ncbi Scrotal edema secondary to fluid imbalance in patients on continuous peritoneal dialysis
    Muniru Adeniyi
    Section of Nephrology, Raymond G Murphy VA Medical Center, Albuquerque, New Mexico 87108, USA
    Adv Perit Dial 25:68-71. 2009
    ..sac or into the anterior abdominal wall through the track of the catheter for continuous peritoneal dialysis (CPD)--scrotal edema in CPD patients may result from generalized volume retention...
  11. pmc Modulatory effects of NMDA on phosphoinositide responses evoked by the metabotropic glutamate receptor agonist 1S,3R-ACPD in neonatal rat cerebral cortex
    R A Challiss
    Department of Cell Physiology and Pharmacology, University of Leicester
    Br J Pharmacol 112:231-9. 1994
    ..in response to the metabotropic glutamate receptor agonist 1-aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) has been examined in neonatal rat cerebral cortex slices. 2...
  12. ncbi Persistent ERK phosphorylation negatively regulates cAMP response element-binding protein (CREB) activity via recruitment of CREB-binding protein to pp90RSK
    Ziqiu Wang
    Liver Cancer Center, Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:11138-44. 2003
    Compound 5 (Cpd 5) or 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone, is an inhibitor of protein phosphatase Cdc25A and causes persistent activation of extracellular signal-regulated kinase (ERK) and cell growth inhibition...
  13. ncbi Analysis of gene- and strand-specific repair in the moderately UV-sensitive Saccharomyces cerevisiae rad23 mutant
    R A Verhage
    Laboratory of Molecular Genetics, Leiden Institute of Chemistry, Leiden University, The Netherlands
    Mutat Res 362:155-65. 1996
    ..investigate whether the rad23 mutant has similar strand-specific repair characteristics we analyzed gene-specific CPD removal from several loci using strand-specific probes but did not detect any repair...
  14. ncbi [Value of the association of blood cardioplegia and energetic warm reperfusion in cardiac transplantation]
    A Pavie
    Service de chirurgie cardiovasculaire, , Paris
    Arch Mal Coeur Vaiss 84:795-800. 1991
    ..Reinjection every 20 minutes allows cellular reoxygenation, the delivery of essential elements (Tham, CPD), and the elimination of products of myocardial degradation accumulated during ischemia...
  15. pmc Excitatory amino acid receptor-stimulated phosphoinositide turnover in primary cerebrocortical cultures
    G J Birrell
    Parke Davis Pharmaceutical Research Division, Warner Lambert Company, Ann Arbor, MI 48106
    Br J Pharmacol 109:379-85. 1993
    ..amino acid receptor agonists were quisqualate, (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD), ibotenate and glutamate with mean EC50 values of 0.9 +/- 0...
  16. ncbi Peptide aldehyde complexes with wheat serine carboxypeptidase II: implications for the catalytic mechanism and substrate specificity
    T L Bullock
    Institute of Molecular Biology, University of Oregon, Eugene 97403, USA
    J Mol Biol 255:714-25. 1996
    The structures of two ternary complexes of wheat serine carboxypeptidase II (CPD-WII), with a tetrapeptide aldehyde and a reaction product arginine, have been determined by X-ray crystallography at room temperature and -170 degrees...
  17. ncbi Effectiveness of a high school smoking cessation program
    W P Adelman
    Division of General Pediatrics and Adolescent Medicine, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
    Pediatrics 107:E50. 2001
    ..To evaluate the impact of a school-based smoking cessation program targeting adolescents interested in quitting...
  18. ncbi Increasing the dialysis volume and frequency in a fixed period of time in CPD patients: the effect on Kpt/V and creatinine clearance
    Peter H Juergensen
    New Haven CAPD, New Haven, Connecticut 06511, USA
    Perit Dial Int 22:693-7. 2002
    ..recommendations for weekly Kt/V(urea) and weekly total creatinine clearance (CC) in chronic peritoneal dialysis (CPD) patients...
  19. ncbi Metabotropic glutamate receptors (mGluRs) are involved in early phase of memory formation: possible role of modulation of glutamate release
    Elzbieta Salinska
    Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02 106 Warsaw, Poland
    Neurochem Int 43:469-74. 2003
    ..I.c.v. injection of the mGluRs agonist 1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) can impair memory formation in some types of learning task...
  20. ncbi The metabotropic glutamate receptors of the vestibular organs
    P S Guth
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, LA 70112 2699, USA
    Hear Res 125:154-62. 1998
    ..The mGluR agonist +/- 1-aminocyclopentane-trans-1,3-dicarboxylate (ACPD) produced an increase in afferent firing rates of the ampullar nerve of the intact posterior canal...
  21. ncbi Metabotropic glutamate receptors modulate synaptic transmission in the perforant path: pharmacology and localization of two distinct receptors
    D Dietrich
    Department of Neurosurgery, University of Bonn Medical Center, Germany
    Brain Res 767:220-7. 1997
    ..In the present study, the specific mGluR agonists (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) and L(+)-2-amino-4-phosphonobutyric acid (L-AP4) depressed field excitatory postsynaptic potentials (fEPSPs) in ..
  22. pmc Signal transduction pathways involved in the acute potentiation of NMDA responses by 1S,3R-ACPD in rat hippocampal slices
    J Harvey
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 109:1085-90. 1993
    ..the acute potentiation of N-methyl-D-aspartate (NMDA) responses by aminocyclopentane-1S,3R-dicarboxylic acid (1S,3R-ACPD) in area CA1 of rat hippocampal slices. 2...
  23. ncbi Intermittent versus continuous intraperitoneal glycopeptide/ceftazidime treatment in children with peritoneal dialysis-associated peritonitis. The Mid-European Pediatric Peritoneal Dialysis Study Group (MEPPS)
    F Schaefer
    Division of Pediatric Nephrology, University Children s Hospital, Heidelberg, Germany
    J Am Soc Nephrol 10:136-45. 1999
    ..administration appears as a practical and economical therapeutic concept in continuous peritoneal dialysis (CPD)-related peritonitis, but the equivalence of this principle with standard continuous treatment awaits confirmation ..
  24. ncbi Protein phosphatase 2A binds to the cytoplasmic tail of carboxypeptidase D and regulates post-trans-Golgi network trafficking
    O Varlamov
    Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 114:311-22. 2001
    Carboxypeptidase D (CPD) is a transmembrane protein that processes proteins in the trans-Golgi network (TGN). A 20-residue region within the cytoplasmic tail of CPD binds protein phosphatase 2A (PP2A)...
  25. doi Cone-beam computerized tomographic, radiographic, and histologic evaluation of periapical repair in dogs' post-endodontic treatment
    Francisco Wanderley Garcia de Paula-Silva
    Department of Pediatric Clinics, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:796-805. 2009
    ..To evaluate the periapical repair after root canal treatment in the teeth of dogs using CT and conventional radiography and to compare these findings with the gold standard microscopic evaluation...
  26. doi Changes in polymorphonuclear leukocyte elastase concentrations and hemolysis parameters in patients transfused with different blood preparations, and in the blood preparations themselves
    Tomoki Nishiyama
    Department of Anesthesiology, The University of Tokyo, Tokyo, Japan
    J Anesth 22:117-24. 2008
    ..The purpose of this study was to compare hemolysis and PMNE concentrations in massive blood transfusions with three different preparations...
  27. ncbi Contrast sensitivity after implantation of a spherical versus an aspherical intraocular lens in biaxial microincision cataract surgery
    Sabine Kurz
    Department of Ophthalmology, Johannes Gutenberg University, Langenbeckstrasse 1, 55131 Mainz, Germany
    J Cataract Refract Surg 33:393-400. 2007
    ....
  28. ncbi Spectroscopic studies of peroxyacetic acid reaction intermediates of cytochrome P450cam and chloroperoxidase
    V Schunemann
    Institute of Physics, Medical University Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    J Inorg Biochem 91:586-96. 2002
    It is generally assumed that the putative compound I (cpd I) in cytochrome P450 should contain the same electron and spin distribution as is observed for cpd I of peroxidases and catalases and many synthetic cpd I analogues...
  29. doi Self-assessment in CPD: lessons from the UK undergraduate and postgraduate education domains
    Tim Dornan
    University of Manchester, Manchester, England
    J Contin Educ Health Prof 28:32-7. 2008
    ..is moving from credit-earning, taught continuing medical education (CME) to a continuing professional development (CPD) system that explicitly links education to change in practice, managed and monitored through mandatory peer ..
  30. ncbi Temperature-sensitive photoreactivation of cyclobutane thymine dimer in soybean
    Ayumi Yamamoto
    Graduate School of Life Sciences, Tohoku University, Japan
    J Radiat Res 49:189-96. 2008
    UV radiation induces the formation of two classes of photoproducts in DNA, the cyclobutane pyrimidine dimer (CPD) and the pyrimidine 6-4 pyrimidone photoproduct...
  31. pmc Modulation of plateau properties in dorsal horn neurones in a slice preparation of the turtle spinal cord
    R E Russo
    Department of Medical Physiology, Panum Institute, University of Copenhagen, Denmark
    J Physiol 499:459-74. 1997
    ..2. Application of cis-(+/-)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD, 10-50 microM) produced a slow depolarization (5.9 +/- 0...
  32. pmc Pharmacology of postsynaptic metabotropic glutamate receptors in rat hippocampal CA1 pyramidal neurones
    C H Davies
    Department of Pharmacology, Medical School, University of Birmingham
    Br J Pharmacol 116:1859-69. 1995
    ..were observed with concentrations (50-100 microM) of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid ((1S,3R)-ACPD) and (1S,3S)-ACPD that exhibit little or no activity at group III mGluRs but which activate groups I and II mGluRs...
  33. ncbi Chronic peritoneal dialysis catheters in children: a fifteen-year experience of the Italian Registry of Pediatric Chronic Peritoneal Dialysis
    Stefano Rinaldi
    Department of Nephrology and Urology, Bambino Gesu Children s Research Hospital, Piazza S Onofrio 4, 00165 Rome, Italy
    Perit Dial Int 24:481-6. 2004
    To analyze data on 503 chronic peritoneal dialysis (CPD) catheters implanted between 1986 and 2000 in pediatric patients enrolled in the Italian Registry of Pediatric Chronic Peritoneal Dialysis (the Registry), comparing three different ..
  34. doi A review of the efficacy of smoking-cessation pharmacotherapies in nonwhite populations
    Gisela I Robles
    Department of Pharmacy Practice, College of Pharmacy, Nova Southeastern University, Ft Lauderdale, Florida 33328, USA
    Clin Ther 30:800-12. 2008
    ..Research suggests that behavioral support strategies and pharmacotherapy can improve abstinence rates. However, both approaches, especially pharmacotherapy, have been understudied in nonwhite US populations...
  35. ncbi Effects of a selective metabotropic glutamate receptor agonist on the micturition reflex pathway in urethane-anesthetized rats
    Hiroshi Tanaka
    The Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurourol Urodyn 22:611-6. 2003
    ..To determine a possible role of metabotropic glutamate receptors in the spinobulbospinal micturition reflex pathway in the rat...
  36. ncbi What do you mean you can't sterilize it? The reusable medical device matrix
    Anne Stephens
    University Health Network, Toronto General Hospital, USA
    Can Oper Room Nurs J 28:6-11, 20-4. 2010
    ..will be referred to as RMDs and include all instrumentation and devices that the Central Processing Department (CPD) resterilizes for use in the hospital. Patient safety in surgery begins in CPD...
  37. ncbi Regulation of immediate early gene c-fos and zif/268 mRNA expression in rat striatum by metabotropic glutamate receptor
    J Q Wang
    Department of Pharmacology, Howard University College of Medicine, 520 W Street NW, Washington, DC 20059, USA
    Brain Res Mol Brain Res 57:46-53. 1998
    ..pharmacological activation of metabotropic glutamate receptors by intrastriatal injection of a selective agonist, ACPD, elevated immediate early gene c-fos and zif/268 mRNA expression in the injected dorsal striatum as revealed by ..
  38. pmc Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi
    David J Bell
    Tropical and Infectious Diseases Unit, Royal Liverpool University Hospital, Liverpool L7 8XP, UK
    Malar J 8:204. 2009
    ..At the time of this study, artemether-lumefantrine (AL) and chlorproguanil-dapsone (CPD), both multi-dose regimes, were considered possible alternatives to SP in Malawi...
  39. ncbi Pharmacological similarity between the retinal APB receptor and the family of metabotropic glutamate receptors
    N Tian
    Department of Biophysical Sciences, School of Medicine, State University of New York, Buffalo 14214
    J Neurophysiol 71:2258-68. 1994
    ..experiments in the amphibian retina to examine the effects of 1-amino-1,3-cyclopentanedicarboxylic acid (1S,3R ACPD), which is a selective agonist for the family of metabotropic glutamate receptors. 2...
  40. pmc Randomised trial investigating effect of a novel nicotine delivery device (Eclipse) and a nicotine oral inhaler on smoking behaviour, nicotine and carbon monoxide exposure, and motivation to quit
    K O Fagerstrom
    Smokers Information Center and Fagerstrom Consulting, Helsingborg, Sweden
    Tob Control 9:327-33. 2000
    ..The smoker's own brand of cigarette and a nicotine replacement product (Nicotrol inhaler) were used as comparisons...
  41. ncbi Metabotropic glutamate receptor agonist increases neuropeptide mRNA expression in rat striatum
    J Q Wang
    Department of Pharmacology, Howard University College of Medicine, 520 W Street NW, Washington, DC 20059, USA
    Brain Res Mol Brain Res 54:262-9. 1998
    ..the effects of acute injection of the selective mGluR agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) on behavior and striatal neuropeptide mRNA expression were evaluated in chronically-cannulated rats...
  42. ncbi Presynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus
    D Dietrich
    Experimental Neurophysiology, Department of Neurosurgery, University Clinic Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Neuropharmacology 42:297-305. 2002
    ..The broad spectrum mGluR agonist (1S, 3R)-1-aminocyclopentane-1,3-dicarboxylic acid (ACPD) profoundly and reversibly reduced field EPSPs (fEPSPs) with an EC(50) of 30+/-7.4 microM...
  43. doi Continuing professional development and social accountability: a review of the literature
    Lisa J Fleet
    Memorial University of Newfoundland, St Johns, NL, Canada
    J Interprof Care 22:15-29. 2008
    ..to the society they serve is not a new concept and by the 1990 s, the continuing professional development (CPD) of health professionals was being seen as one way in which Canadians' level of health could be improved...
  44. ncbi Use of the TAT in the assessment of DSM-IV cluster B personality disorders
    S J Ackerman
    Department of Psychology, University of Arkansas, USA
    J Pers Assess 73:422-48. 1999
    ..borderline personality disorder (BPD), narcissistic personality disorder (NPD), and Cluster C personality disorder (CPD)...
  45. ncbi K vitamins, PTP antagonism, and cell growth arrest
    Brian I Carr
    Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Cell Physiol 193:263-74. 2002
    ..b>Cpd 5 or [2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone] is one of the most potent...
  46. doi Continuing professional development is associated with increasing physical therapists' roles in arthritis management in Canada and the Netherlands
    Linda C Li
    Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada
    Phys Ther 90:629-42. 2010
    This study explored the relationships among the roles assumed by physical therapists in arthritis care and their previous participation in arthritis courses for continuing professional development (CPD).
  47. ncbi Safety and efficacy of the nicotine patch and gum for the treatment of adolescent tobacco addiction
    Eric T Moolchan
    Teen Tobacco Addiction Research Clinic, Clinical Pharmacology and Therapeutics Research Branch, National Institute on Drug Abuse, Intramural Research Program, 5500 Nathan Shock Dr, Baltimore, Maryland 21224, USA
    Pediatrics 115:e407-14. 2005
    ..To determine the safety and efficacy of the nicotine patch and gum for adolescents who want to quit smoking...
  48. ncbi Adaptive enhancement and kinetics of nucleotide excision repair in humans
    N Ye
    Beckman Research Institute, Department of Biology, City of Hope Medical Center, Duarte, CA 91010, USA
    Mutat Res 435:43-61. 1999
    ..dose of quinacrine mustard (QM) preceded the UVC challenge, the duration of the cyclobutane pyrimidine dimer (CPD) repair lags were reduced by a factor of three and the kinetic half-lives for CPD repair were reduced by a factor ..
  49. ncbi Clostridial antibody response from injection-site lesions in beef cattle, long-term response to single or multiple doses, and response in newborn beef calves
    T R Troxel
    University of Arkansas Cooperative Extension Service, Little Rock 72203, USA
    J Anim Sci 79:2558-64. 2001
    ..08) and 84 (P < 0.07) compared with non-lesioned heifers. Clostridium sordellii (CS) and perfringens type D (CPD) antibody titers were greater in lesioned heifers than in non-lesioned heifers on d 28 and 56. In Exp...
  50. ncbi Changes in hemorheological and biochemical parameters following short-term and long-term smoking cessation induced by nicotine replacement therapy (NRT)
    K O Haustein
    Fritz Lickint Institute for Nicotine Research and Smoking Cessation, Erfurt, Germany
    Int J Clin Pharmacol Ther 42:83-92. 2004
    ..We investigated the effect of stopping smoking by using nicotine replacement therapy (NRT) on hemorheology parameters, on the cotinine and thiocyanate plasma concentrations and the exhaled carbon monoxide (CO)...
  51. ncbi A free energy calculation study of the effect of H-->F substitution on binding affinity in ligand-antibody interactions
    Minoru Saito
    Faculty of Science and Technology, Hirosaki University, 3 Bunkyo cho, Hirosaki, Aomori 036 8561, Japan
    J Comput Chem 26:272-82. 2005
    ..attributable to H-->F substitution by comparing results for CPDs containing a trifluoroacetylamino group (CPD-F) or an acetylamino group (CPD-H). The calculated DeltaDeltaG, DeltaDeltaH, and -TDeltaDeltaS values were -2.9, -6...
  52. ncbi A prospective multicentre study of the nutritional status in children on chronic peritoneal dialysis
    Alberto Edefonti
    Pediatric Renal Unit of Clinica Pediatrica G e D de Marchi, Fondazione Policlinico, Mangiagalli, Regina Elena, Milano, Italy
    Nephrol Dial Transplant 21:1946-51. 2006
    ..score is a recently proposed objective method of assessing malnutrition in children on chronic peritoneal dialysis (CPD) that uses nine parameters based on anthropometry, skinfold thickness and bioimpedance analysis...
  53. doi Fasciola hepatica: histological changes in the reproductive structures of triclabendazole (TCBZ)-sensitive and TCBZ-resistant flukes after treatment in vivo with TCBZ and the related benzimidazole derivative, Compound Alpha
    R E B Hanna
    Veterinary Sciences Division, Agri Food and Biosciences Institute, Stormont, Northern Ireland, United Kingdom
    Vet Parasitol 168:240-54. 2010
    ..after infection the lambs were treated with TCBZ (10mg/kg) or with the experimental fasciolicide, Compound Alpha (Cpd alpha), a benzimidazole derivative of TCBZ (15mg/kg)...
  54. ncbi Spatial luminance contrast sensitivity measured with transient VEP: comparison with psychophysics and evidence of multiple mechanisms
    Givago S Souza
    Departamento de Fisiologia, Universidade Federal do Para, Brazil
    Invest Ophthalmol Vis Sci 48:3396-404. 2007
    ..To compare the spatial luminance contrast sensitivity function (CSF) obtained with transient visual evoked potentials (VEPs) with that obtained with psychophysical measurements...
  55. doi Smoking reduction fails to improve clinical and biological markers of cardiac disease: a randomized controlled trial
    Anne M Joseph
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN 55414, USA
    Nicotine Tob Res 10:471-81. 2008
    ..received counseling and nicotine replacement therapy to encourage > or =50% reduction in cigarettes per day (CPD)...
  56. ncbi 6MAP, a fluorescent adenine analogue, is a probe of base flipping by DNA photolyase
    Kongsheng Yang
    Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA
    J Phys Chem B 111:10615-25. 2007
    ..We have used the fluorescent adenine analogue 6MAP, a pteridone, to probe the local double helical structure of the CPD substrate when bound by photolyase...
  57. ncbi Ultraviolet-induced cyclobutane pyrimidine dimers are selectively removed from transcriptionally active genes in the epidermis of the hairless mouse
    H J Ruven
    Department of Radiation Genetics and Chemical Mutagenesis, Leiden University, The Netherlands
    Cancer Res 53:1642-5. 1993
    This study describes the induction and repair of UV-induced cyclobutane pyrimidine dimers (CPD) in transcriptionally active and inactive genes in the epidermis of the hairless mouse...
  58. ncbi Power Doppler ultrasound imaging for quantification of urinary bladder neck blood flow changes
    Antonius Schuster
    Department of Radiology, LKH Feldkirch, Feldkirch A 6800, Austria
    Ultrasound Med Biol 30:1379-84. 2004
    ..Computer-assisted calculation of color pixel density (CPD) of power Doppler images was performed using Scion Image) software image analysis...
  59. ncbi Induction and inhibition of cyclobutane pyrimidine dimer photolyase in etiolated cucumber (Cucumis sativus) cotyledons after ultraviolet irradiation depends on wavelength
    Yuichi Takeuchi
    Department of Bioscience and Technology, School of Engineering, Hokkaido Tokai University, Sapporo, Japan
    J Plant Res 120:365-74. 2007
    ..maximum energy at 327 nm) the activity of DNA photolyase specific to cyclobutane pyrimidine dimers (CPDs), CPD photolyase, increased by an amount which depended on UV irradiance, and the level of CPD photolyase gene (CsPHR) ..
  60. ncbi Scottish pharmacists' views and attitudes towards continuing professional development
    Ailsa Power
    NHS Education for Scotland, 2 Central Quay, 89 Hydepark St, Glasgow G3 8BW, Scotland
    Pharm World Sci 30:136-43. 2008
    To summarise Scottish pharmacists' views and attitudes towards Continuing Professional Development (CPD).
  61. ncbi Nutrition indices in obese continuous peritoneal dialysis patients with inadequate and adequate urea clearance
    Antonios H Tzamaloukas
    Renal Section, New Mexico Veterans Affairs Health Care System, Albuquerque 87108, USA
    Perit Dial Int 22:506-12. 2002
    To test whether better nutrition is associated more with adequate urea clearance than with inadequate urea clearance in obese patients on continuous peritoneal dialysis (CPD).
  62. pmc Treatment and outcome of CPD-associated peritonitis
    Laura Troidle
    New Haven CAPD, Renal Research Institute, New Haven, Connecticut, USA
    Ann Clin Microbiol Antimicrob 5:6. 2006
    b>CPD-associated peritonitis is a leading cause of morbidity and mortality for ESRD patients maintained on CPD therapy. The percentage of ESRD patients maintained on CPD therapy is declining...
  63. pmc Task-dependent role for dorsal striatum metabotropic glutamate receptors in memory
    M G Packard
    Department of Psychology, Yale University, New Haven, Connecticut 06520 8025, USA
    Learn Mem 8:96-103. 2001
    ..0, 2.0 mM/0.5 microL), the group I/II mGluR agonist 1-aminocyclopentane-1,3-carboxylic acid (ACPD; 0.5 or 1.0 microM/0...
  64. ncbi The influence of continuing professional development portfolio records on pharmacy practice
    Andrzej J Kostrzewski
    Guy s and St Thomas NHS Foundation Trust, Pharmacy Department, Guy s Hospital, London
    Int J Pharm Pract 17:107-13. 2009
    ..of this study was to undertake an in-depth investigation of the influence of continuing professional development (CPD) portfolios on pharmacy practice in the hospital setting...
  65. pmc Structure-function analysis of inositol hexakisphosphate-induced autoprocessing of the Vibrio cholerae multifunctional autoprocessing RTX toxin
    Katerina Prochazkova
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA
    J Biol Chem 283:23656-64. 2008
    ..Autoprocessing of this toxin by an embedded cysteine protease domain (CPD) is essential for this toxin to induce actin depolymerization in a broad range of cell types...
  66. ncbi QM/MM study of mechanisms for compound I formation in the catalytic cycle of cytochrome P450cam
    Jingjing Zheng
    Max Planck Institut fur Kohlenforschung, Kaiser Wilhelm Platz 1, D 45470 Mulheim an der Ruhr, Germany
    J Am Chem Soc 128:13204-15. 2006
    ..dioxygen complex, there are fast proton transfers that lead to the formation of the active species, Compound I (Cpd I), which are not well understood because they occur so rapidly...
  67. ncbi New features in the catalytic cycle of cytochrome P450 during the formation of compound I from compound 0
    Devesh Kumar
    Department of Organic Chemistry and the Lise Meitner Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    J Phys Chem B 109:19946-51. 2005
    ..of the catalytic cycle of the enzyme cytochrome P450, namely, the formation of the active species, Compound I (Cpd I), from the ferric-hydroperoxide species (Cpd 0) by a protonation-assisted mechanism...
  68. ncbi Inhibition of rat liver regeneration after partial hepatectomy and induction of ERK phosphorylation by Cpd 5, a K vitamin-based anticancer compound
    Siddhartha Kar
    Department of Surgery, Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh, E1552 Biomedical Science Tower, 200 Lothrop Street, Pittsburgh, PA 15260, USA
    Carcinogenesis 25:2345-51. 2004
    Thioalkyl K vitamin derivatives, like 2-(2-mercaptoethanol)-3-methyl-1,4-naphthoquinone (Cpd 5), have been shown to inhibit both hepatoma cell growth and DNA synthesis in rat hepatocytes in vitro...
  69. ncbi CPD photolyase gene from Spinacia oleracea: repair of UV-damaged DNA and expression in plant organs
    Ryouhei Yoshihara
    The United Graduate School of Agricultural Sciences, Tottori University, Japan
    J Radiat Res 46:157-64. 2005
    ..Specific damage to DNA caused by UV radiation involves the cyclobutyl pyrimidine dimers (CPD) and the pyrimidine (6-4) pyrimidone photoproducts...
  70. ncbi [The study of chronic partial denervation and quality of life in patients with motor neuron disease treated with semax]
    A V Serdiuk
    Zh Nevrol Psikhiatr Im S S Korsakova 107:29-39. 2007
    The study of chronic partial denervation (CPD) and quality of life was carried out in 27 patients with definite, probable and possible diagnosis of motor neuron disease (MND) treated with semax (1% solution)...
  71. ncbi Reconsideration of delayed gastric emptying in pancreaticoduodenectomy
    Yan Shen Shan
    Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    World J Surg 29:873-9; discussion 880. 2005
    ..is higher after pylorus-preserving pancreaticoduodenectomy (PPPD) than after conventional pancreaticoduodenectomy (CPD), but DGE is traditionally diagnosed from patient-reported subjective sensations...
  72. ncbi Fluorinated Cpd 5, a pure arylating K-vitamin derivative, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating MAPK
    Siddhartha Kar
    Liver Cancer Center, Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh PA, USA
    Biochem Pharmacol 72:1217-27. 2006
    ..Among these, Cpd 5 was the most potent...
  73. pmc Spinal canal narrowing during simulated frontal impact
    Paul C Ivancic
    Biomechanics Research Laboratory, Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, 333 Cedar St, P O Box 208071, New Haven, CT 06520 8071, USA
    Eur Spine J 15:891-901. 2006
    ..using a biofidelic whole cervical spine model with muscle force replication, were to quantify canal pinch diameter (CPD) narrowing during frontal impact and to evaluate the potential for cord compression...
  74. ncbi Modulation of dendritic release of dopamine by metabotropic glutamate receptors in rat substantia nigra
    Jorge M Campusano
    Laboratory of Biochemical Pharmacology, Department of Cell and Molecular Biology, Faculty of Biological Sciences, Catholic University of Chile, Alameda 340, P O Box 114 D, Santiago, Chile
    Biochem Pharmacol 63:1343-52. 2002
    ..trans-(+/-)-1-Amino-(1S,3R)-cyclopentane dicarboxylic acid (trans-ACPD; 100 and 600 microM), a group I and II mGluR agonist, evoked the release of [(3)H]DA from nigral slices...
  75. ncbi Transient and sustained ERK phosphorylation and nuclear translocation in growth control
    Takahito Adachi
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pennsylvania 15213, USA
    J Cell Physiol 192:151-9. 2002
    ..We examined the effects of epidermal growth factor (EGF), a growth stimulant, and compound 5 (Cpd 5), a protein-tyrosine phosphatase (PTPase) inhibitor, which inhibits the growth of the same Hep3B hepatoma cells...
  76. ncbi Small solute clearances and nutrition indices in obese patients on continuous peritoneal dialysis
    Antonios H Tzamaloukas
    Renal Section, New Mexico VA Health Care System, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    Adv Perit Dial 18:40-3. 2002
    ..the relationship between obesity, small-solute clearances, and nutrition in continuous peritoneal dialysis (CPD), we compared clearances and nutrition indices between 270 obese and 502 normal-weight CPD patients...
  77. ncbi In vivo deamination of cytosine-containing cyclobutane pyrimidine dimers in E. coli: a feasible part of UV-mutagenesis
    A Burger
    Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Mutat Res 522:145-56. 2003
    We have estimated in vivo deamination rates for cytosines in cyclobutane pyrimidine dimers (CPD or PyPy) in UV-irradiated E. coli deficient in uracil DNA glycosylase...
  78. ncbi Selection of virulent isolates of entomopathogenic hyphomycetes against Clavigralla tomentosicollis Stål. and evaluation in cage experiment using three cowpea varieties
    S Ekesi
    Department of Crop Protection, Ahmadu Bello University, PMB 1044, Zaria, Nigeria
    Mycopathologia 148:131-9. 1999
    ..At all concentrations, Beauveria bassiana CPD 9 and Metarhizium anisopliae CPD 5 caused the highest mortality in adult bug ranging from 58 to 97% and 53 to 100%, ..
  79. ncbi Alkaline CPD and the preservation of RBC 2,3-DPG
    John R Hess
    Blood Research Detachment, Walter Reed Army Institute of Research, Silver Spring, MD 20307, USA
    Transfusion 42:747-52. 2002
    ..Alkaline additive solutions, which can preserve RBCs for up to 11 weeks, still do not preserve 2,3-DPG because the starting pH is below 7.2...
  80. ncbi Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins
    B Xiao
    Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 21:707-16. 1998
    ..These observations support a model in which the dynamic expression of Homer 1a competes with constitutively expressed CC-Homers to modify synaptic mGluR properties...
  81. pmc A continuous professional development process for first-year pharmacy students
    Richard O'Brocta
    Wegmans School of Pharmacy, St John Fisher College, Rochester, NY 14618, USA
    Am J Pharm Educ 76:29. 2012
    To develop, pilot test, and evaluate a continuous professional development (CPD) process for first-year pharmacy (P1) students.
  82. ncbi Global Adult Tobacco Survey (GATS): a case for change in definition, analysis and interpretation of "cigarettes" and "cigarettes per day" in completed and future surveys
    Pratap Kumar Jena
    Project STEPS, Public Health Foundation of India, New Delhi, India and Heath Systems Research India Initiative, Bangalore, India
    Asian Pac J Cancer Prev 14:3299-304. 2013
    The Global Adult Tobacco Survey has 15 key indicators, cigarettes smoked per day (CPD) among daily smokers being one of them...
  83. pmc The interplay of genes and adolescent development in substance use disorders: leveraging findings from GWAS meta-analyses to test developmental hypotheses about nicotine consumption
    Scott I Vrieze
    University of Minnesota, 75 East River Road, Minneapolis, MN 55455, USA
    Hum Genet 131:791-801. 2012
    The present study evaluated gene by development interaction in cigarettes smoked per day (CPD) in a longitudinal community-representative sample (N = 3,231) of Caucasian twins measured at ages 14, 17, 20, and 24...
  84. doi Catalases versus peroxidases: DFT investigation of H₂O₂ oxidation in models systems and implications for heme protein engineering
    Pietro Vidossich
    Unitat de Quimica Fisica, Departament de Quimica, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    J Inorg Biochem 117:292-7. 2012
    ..Both enzymes use one molecule of hydrogen peroxide to form a high valent iron intermediate named Compound I (Cpd I)...
  85. pmc Alpha-5 and -3 nicotinic receptor gene variants predict nicotine dependence but not cessation: findings from the COMMIT cohort
    Chad A Bousman
    Department of Psychiatry, The University of Melbourne, Parkville, Victoria, Australia
    Am J Med Genet B Neuropsychiatr Genet 159:227-35. 2012
    Smoking many cigarettes per day (CPD) and short interval to first cigarette (TTF) after waking are two of the most heritable smoking phenotypes and comprise the Heavy Smoking Index (HSI)...
  86. pmc Genome-wide association study of smoking behaviours in patients with COPD
    Mateusz Siedlinski
    Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Thorax 66:894-902. 2011
    ..identified numerous single nucleotide polymorphisms (SNPs) associated with the number of cigarettes smoked per day (CPD) and a dopamine beta-hydroxylase (DBH) locus associated with smoking cessation in multiple populations...
  87. doi Photoprotection by 1alpha,25-dihydroxyvitamin D and analogs: further studies on mechanisms and implications for UV-damage
    R S Mason
    Department of Physiology, Bosch Institute, Anderson Stuart Bldg F13, University of Sydney, NSW 2006, Australia
    J Steroid Biochem Mol Biol 121:164-8. 2010
    ..1alpha,25-dihydroxyvitamin D3 (1,25D) reduces UV-induced DNA damage in the form of cyclobutane pyrimidine dimers (CPD) in human keratinocytes in culture and in mouse and human skin...
  88. doi Veterinary e-CPD: a new model for providing online continuing professional development for the veterinary profession
    Nick Short
    e Media Unit, Royal Veterinary College, London, UK
    J Vet Med Educ 34:689-94. 2007
    Continuing professional development (CPD) is widely recognized as an important element in effective lifelong learning for veterinary surgeons...
  89. pmc The Potorous CPD photolyase rescues a cryptochrome-deficient mammalian circadian clock
    Inês Chaves
    Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e23447. 2011
    ..investigated the effect of ectopically expressed Arabidopsis thaliana (6-4)PP photolyase and Potorous tridactylus CPD-photolyase (close and distant relatives of mammalian cryptochromes, respectively), on the performance of the ..
  90. doi Anthropometric measurements as predictors of cephalopelvic disproportion: Can the diagnostic accuracy be improved?
    Santosh J Benjamin
    Department of Obstetrics and Gynaecology, Christian Medical College, Vellore, Tamilnadu, India Department of Community Medicine Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal, Karnataka, India
    Acta Obstet Gynecol Scand 91:122-7. 2012
    We assessed the efficacy of maternal anthropometric measurements and clinical estimates of fetal weight in isolation and in combination as predictors of cephalopelvic disproportion (CPD).
  91. doi British pharmacy professionals' beliefs and participation in continuing professional development: a review of the literature
    Parastou Donyai
    Reading School of Pharmacy, University of Reading, Berkshire, UK
    Int J Pharm Pract 19:290-317. 2011
    OBJECTIVES  Continuing professional development (CPD) has potential to be useful in pharmacy revalidation but past uptake and attitudes to CPD in Great Britain (GB) need to be mapped...
  92. doi Participation in continuing professional development by Victorian dental practitioners in 2004
    M S Hopcraft
    Cooperative Research Centre for Oral Health Sciences, School of Dental Science, The University of Melbourne, Victoria, Australia
    Aust Dent J 53:133-9. 2008
    Continuing professional development (CPD) has been long considered an integral component of professional practice across a range of health professions...
  93. pmc Novel candidate colorectal cancer biomarkers identified by methylation microarray-based scanning
    Yuriko Mori
    Division of Gastroenterology, Department of Medicine, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, Maryland 21205, USA
    Endocr Relat Cancer 18:465-78. 2011
    ..I (NPTX1), ALX homeobox 3 (ALX3), miR-34b, glucagon-like peptide 1 receptor (GLP1R), BTG4, homer homolog 2 (HOMER2), zinc finger protein 583 (ZNF583), and gap junction protein, gamma 1 (GJC1)...
  94. doi Cryoprotective dehydration is widespread in Arctic springtails
    Jesper Givskov Sørensen
    National Environmental Research Institute, Aarhus University, Department of Terrestrial Ecology, Vejlsøvej 25, P O Box 314, DK 8600 Silkeborg, Denmark
    J Insect Physiol 57:1147-53. 2011
    Cryoprotective dehydration (CPD) is a cold tolerance strategy employed by small invertebrates that readily lose water by evaporation when subjected to sub-zero temperatures in the presence of ice...
  95. doi Replicated genetic evidence supports a role for HOMER2 in schizophrenia
    William P Gilks
    Neuropsychiatric Genetics Research Group, Institute for Molecular Medicine and Department of Psychiatry, Trinity College Dublin, Ireland
    Neurosci Lett 468:229-33. 2010
    ..Following a search for functionally relevant genes with evidence of linkage to schizophrenia, we selected HOMER2 for as a candidate gene for investigation using a multi-stage association design...
  96. ncbi Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells
    Kwan Yi Chu
    Laboratory of Molecular Signaling in Diabetes, Diabetes Research Group, Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada
    Islets 3:155-65. 2011
    ..that lipotoxicity led to the degradation of CPE, but did not affect its related enzyme, carboxypeptidase D (CPD). In this study, we found that CPD was significantly up-regulated by elevated glucose, while CPE was not...
  97. doi Composition, structure and substrate properties of reconstituted discoidal HDL with apolipoprotein A-I and cholesteryl ester
    Alexander D Dergunov
    National Research Centre for Preventive Medicine, Moscow, Russia
    Spectrochim Acta A Mol Biomol Spectrosc 75:1100-7. 2010
    ..PLPC), palmitoyloleoylphosphatidylcholine (POPC), and fluorescent probe cholesteryl 1-pyrenedecanoate (CPD) that forms in a diffusion- and concentration-dependent manner short-lived dimer of unexcited and excited molecules ..
  98. pmc Purification and characterization of two serine carboxypeptidases from Aspergillus niger and their use in C-terminal sequencing of proteins and peptide synthesis
    F Dal Degan
    Protein Chemistry Unit, Institut National de la Recherche Agronomique, Jouy en Josas, France
    Appl Environ Microbiol 58:2144-52. 1992
    A procedure was developed to prepare in large amounts two carboxypeptidases, CPD-I and CPD-II, from Aspergillus niger. They were each shown to be serine proteases and single-chain monomers with molecular masses of ca...
  99. pmc CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592
    Elsa Nicolas
    Faculte de Medecine de la Timone, INSERM UMR_S 910, Génétique Médicale et Génomique Fonctionnelle, Universite de la Mediterranee, Marseille, France
    Eur J Hum Genet 18:1107-13. 2010
    ....
  100. ncbi Continuous peritoneal dialysis compared with daily hemodialysis in patients with acute kidney injury
    Daniela Ponce Gabriel
    Department of Internal Medicine, University Hospital, Botucatu School of Medicine, Sao Paulo State University, Sao Paulo, Brazil
    Perit Dial Int 29:S62-71. 2009
    ..We performed a prospective study to determine the effect of continuous peritoneal dialysis (CPD), as compared with daily hemodialysis (dHD), on survival among patients with AKI.
  101. doi Exposure to a tobacco-specific lung carcinogen in adolescent versus adult smokers
    Louise A Hertsgaard
    University of Minnesota Transdisciplinary Tobacco Use Research Center, 2701 University Avenue Southeast, 201, Minneapolis, MN 55414, USA
    Cancer Epidemiol Biomarkers Prev 17:3337-43. 2008
    Previous studies with adult smokers have shown an association between number of cigarettes smoked per day (CPD) and levels of biomarkers of exposure to the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (..

Research Grants82

  1. FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPES
    P Conn; Fiscal Year: 1993
    ..Interestingly, application of IS,3R- ACPD (a selective mGluR agonist) to hippocampal slices, potentiates cyclic AMP responses to agonists of other receptors ..
  2. Prevention of UV-carcinogenesis through DNA repair-dependent immunomodulation
    Hui Xu; Fiscal Year: 2010
    ..We have demonstrated that silymarin has the ability to enhance the removal or repair of CPD+ cells in UV-exposed skin, and inhibits UVB-induced suppression of the contact hypersensitivity response in mice...
  3. EPILEPTOGENESIS IN THE AMYGDALA
    Patricia Shinnick Gallagher; Fiscal Year: 1993
    ..aims will be addressed: 1) analyze the effects of the specific metabotropic glutamate receptor agonist, 1S, 3R-ACPD, on the electrophysiological properties of BLA neurons and determine the mechanism of action on specific membrane ..
  4. RADIATION INDUCED CELLULAR MUTAGENESIS AND DNA REPAIR
    RICHARD BOCKRATH; Fiscal Year: 2001
    ..photolyase that occur without the light that normally energizes monomerization of cyclobutane pyrimidine dimers (CPD), the most stable photo-product produced by ultraviolet radiation in DNA...
  5. DNA PHOTOLESION STRUCTURE-ACTIVITY RELATIONSHIPS
    JOHN STEPHEN ADOLFINO TAYLOR; Fiscal Year: 2010
    ..of these C to T mutations appear to arise from a deamination bypass mechanism, in which the C or methylC (mC) in a CPD deaminates to U or T which directs the insertion of A by polymerase eta...
  6. DNA PHOTOLESION STRUCTURE-ACTIVITY RELATIONSHIPS
    John Stephen Taylor; Fiscal Year: 2007
    ..of these C to T mutations appear to arise from a deamination bypass mechanism, in which the C or methylC (mC) in a CPD deaminates to U or T which directs the insertion of A by polymerase eta...
  7. Repair of Genotoxic Damage in Chromatin
    Altaf A Wani; Fiscal Year: 2010
    ..damaged chromatin, (ii) the slow and fast repair rates of two main UV photolesions, cyclobutane pyrimidine dimers (CPD) and pyrimidine(6-4)pyrimidone photoproducts (6-4PP), are dependent on different chromatin remodeling machineries, (..
  8. Repair of Genotoxic Damage in Chromatin
    Altaf Wani; Fiscal Year: 2007
    ..damaged chromatin, (ii) the slow and fast repair rates of two main UV photolesions, cyclobutane pyrimidine dimers (CPD) and pyrimidine(6-4)pyrimidone photoproducts (6-4PP), are dependent on different chromatin remodeling machineries, (..
  9. PROCESSING OF UV-INDUCED DNA DAMAGE IN MAMMALIAN CELLS.
    ERIC MOON SHONG TANG; Fiscal Year: 2004
    Ultraviolet light induced cyclobutane pyrimidine dimers (CPD) lesions are the major DNA damage that organis have faced during eons of evolution, therefore, it is conceivable that cells may have developed mechanisms to modify CPD to ..
  10. UV DAMAGE, REPAIR AND MUTAGENESIS
    GERD PFEIFER; Fiscal Year: 2003
    ..changes the mutational spectra, which photoproduct contributes most to mutagenesis, what the contribution of CPD deamination to UV mutagenicity is, and whether the frequency of UV-specific mutations correlates with photoproduct ..
  11. Molecular regulation of CeA glutamate and binge drinking
    Karen Kathleen Szumlinski; Fiscal Year: 2010
    ..A significant body of functional data from my laboratory demonstrates that alcohol-induced increases in mGluR5/Homer2 pathway activity (via PI3K and PKC5) within the nucleus accumbens (NAC) shell as important for the propensity to ..
  12. A counterpulsation device to promote myocardial recovery
    Paul Spence; Fiscal Year: 2006
    ..The counterpulsation device (CPD) is designed to be implanted via a surface operation in the shoulder area (pacemaker pocket) by attaching it to the ..
  13. Skin Cancer Chemoprevention by Silibinin: Mechanisms and Efficacy
    Rajesh Agarwal; Fiscal Year: 2010
    ..We have also found that silibinin lowers UVB-caused DNA damage in terms of cyclobutane pyrimidine dimmer (CPD) positive cells and further enhances p53 protein level in mouse skin epidermal cell, and selectively increases E2F1 ..
  14. Portable pneumatic driver for counterpulsation therapy
    Paul Spence; Fiscal Year: 2007
    ..The system consists of a 32-ml counterpulsation device (CPD) that is designed to be implanted via a surface operation in the shoulder area (pacemaker pocket)...
  15. Reactivity of Transient Cyt P450 Oxygen Intermediates
    John Dawson; Fiscal Year: 2009
    ..those involving oxygen: oxy-ferrous, peroxo-ferric, hydroperoxo-ferric, and oxo-iron(IV) [compound I, Cpd I, oxo-iron(IV)porph+]. 2 similar oxo species, compounds II and ES, will also be examined...
  16. Reactivity of Transient Cyt P450 Oxygen Intermediates
    John Dawson; Fiscal Year: 2007
    ..those involving oxygen: oxy-ferrous, peroxo-ferric, hydroperoxo-ferric, and oxo-iron(IV) [compound I, Cpd I, oxo-iron(IV)porph+]. 2 similar oxo species, compounds II and ES, will also be examined...
  17. RNA POLYMERASE II AND DNA REPAIR
    Philip Hanawalt; Fiscal Year: 2002
    ..propose to determine the structural properties of transcription complexe arrested at cyclobutane pyrimidine dimer (CPD) or other lesions...
  18. Homer-mediated signaling and cocaine addiction
    Karen Kathleen Szumlinski; Fiscal Year: 2010
    ..Behavioral genetic studies indicated that a cocaine-induced increase in prefrontal cortex (PFC) Homer2 protein levels is sufficient, while a reduction in nucleus accumbens (NAC) Homer2 protein levels is both necessary ..
  19. Role of RNA Polymerase ll in DNA Repair
    Philip Hanawalt; Fiscal Year: 2007
    ..the protein-interactions of the RNA polymerase complex when it is arrested at a cyclobutane pyrimidine dimer (CPD)...
  20. STRUCTURE/FUNCTION OF CARBOXYPEPTIDASES
    RANDAL SKIDGEL; Fiscal Year: 2002
    ..Hypothesis 2: The three carboxypeptidase homology domains of CPD are unique: Domains 1 and 2 are active CPs with unique specificities whereas domain 3 is inactive, but binds ..
  21. Genetics of Nicotine Dependence
    Wade H Berrettini; Fiscal Year: 2010
    ..A genome-wide association (WGA) study of cigarettes per day (CPD), as a quantitative trait, was conducted with ~ 7500 individuals of European origin...
  22. Genetics of Nicotine Dependence
    Wade Berrettini; Fiscal Year: 2009
    ..A genome-wide association (WGA) study of cigarettes per day (CPD), as a quantitative trait, was conducted with ~ 7500 individuals of European origin...
  23. High-Performance Pattern Analysis for CT Colonography
    Peter Santago; Fiscal Year: 2007
    ..Our long term goal is to develop robust CARD methods by focusing on computer polyp detection (CPD) and high-performance pattern analysis (HPPA)...
  24. Effects of Menthol on Bupropion Pharmacokinetics
    Kolawole Okuyemi; Fiscal Year: 2006
    ..Matching will be by age, gender, cigarettes per day smoked (CPD), and body mass index (BMI)...