HOMER1

Summary

Gene Symbol: HOMER1
Description: homer scaffold protein 1
Alias: HOMER, HOMER1A, HOMER1B, HOMER1C, SYN47, Ves-1, homer protein homolog 1, homer homolog 1, homer scaffolding protein 1, homer, neuronal immediate early gene, 1, homer-1
Species: human
Products:     HOMER1

Top Publications

  1. Ward C, Feng W, Tu J, Pessah I, Worley P, Schneider M. Homer protein increases activation of Ca2+ sparks in permeabilized skeletal muscle. J Biol Chem. 2004;279:5781-7 pubmed
    Members of the Homer family of proteins are known to form multimeric complexes capable of cross-linking plasma membrane channels (e.g. metabotropic glutamate receptor) and intracellular Ca2+ release channels (e.g...
  2. Klugmann M, Symes C, Leichtlein C, Klaussner B, Dunning J, Fong D, et al. AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats. Mol Cell Neurosci. 2005;28:347-60 pubmed
    ..We dissected the functional roles of the individual Homer 1 domains, encoded by Homer 1a, 1c, and 1g, in vivo...
  3. Brakeman P, Lanahan A, O Brien R, Roche K, Barnes C, Huganir R, et al. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature. 1997;386:284-8 pubmed
    ..Here we report a novel dendritic protein, Homer, that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked ..
  4. Xiao B, Tu J, Petralia R, Yuan J, Doan A, Breder C, et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron. 1998;21:707-16 pubmed
    b>Homer is a neuronal immediate early gene (IEG) that is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs)...
  5. Tu J, Xiao B, Naisbitt S, Yuan J, Petralia R, Brakeman P, et al. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 1999;23:583-92 pubmed
    ..1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form multivalent complexes that bind proline-rich motifs in group 1 metabotropic glutamate ..
  6. Xiao B, Tu J, Worley P. Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol. 2000;10:370-4 pubmed
    The proteins of the Homer family bind to proline-rich sequences in group I metabotropic glutamate receptors, inositol trisphosphate receptors, ryanodine receptors, and Shank family proteins...
  7. Tu J, Xiao B, Yuan J, Lanahan A, Leoffert K, Li M, et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron. 1998;21:717-26 pubmed
    ..Previously, we demonstrated that mGluRs form natural complexes with members of a family of Homer-related synaptic proteins...
  8. Yuan J, Kiselyov K, Shin D, Chen J, Shcheynikov N, Kang S, et al. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell. 2003;114:777-89 pubmed
    ..Here, we demonstrate that the adaptor protein, termed Homer, facilitates a physical association between TRPC1 and the IP(3)R that is required for the TRP channel to respond ..
  9. Hadsell D, Hadsell L, Rijnkels M, Carcamo Bahena Y, Wei J, Williamson P, et al. In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1. Mamm Genome. 2018;29:632-655 pubmed publisher
    ..locus (Mmcq9) on chromosome 1 contained an SNP that localized to a STAT5 binding region and intersected with a HOMER motif predicted to bind the transcriptional regulator E74-Like ETS transcription factor 5...

More Information

Publications120 found, 100 shown here

  1. Jarius S, Wildemann B. 'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 2: Anti-PKC-gamma, anti-GluR-delta2, anti-Ca/ARHGAP26 and anti-VGCC. J Neuroinflammation. 2015;12:167 pubmed publisher
    ..Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein ..
  2. Jarius S, Wildemann B. 'Medusa head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 3: Anti-Yo/CDR2, anti-Nb/AP3B2, PCA-2, anti-Tr/DNER, other antibodies, diagnostic pitfalls, summary and outlook. J Neuroinflammation. 2015;12:168 pubmed publisher
    ..Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein ..
  3. Li C, Chai S, Ju Y, Hou L, Zhao H, Ma W, et al. Pu-erh Tea Protects the Nervous System by Inhibiting the Expression of Metabotropic Glutamate Receptor 5. Mol Neurobiol. 2017;54:5286-5299 pubmed publisher
    ..Pu-erh tea also inhibited the expression of Homer, one of the synaptic scaffolding proteins binding to mGluR5...
  4. Maher P, van Leyen K, Dey P, Honrath B, Dolga A, Methner A. The role of Ca2+ in cell death caused by oxidative glutamate toxicity and ferroptosis. Cell Calcium. 2018;70:47-55 pubmed publisher
    ..Ca2+ sensor STIM1, the plasma membrane Ca2+ channels Orai1 and TRPC1 and the linking protein Homer protects against oxidative glutamate toxicity and direct oxidative stress caused by hydrogen peroxide or 1-methyl-..
  5. Meyers J, Salling M, Almli L, Ratanatharathorn A, Uddin M, Galea S, et al. Frequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathways. Transl Psychiatry. 2015;5:e586 pubmed publisher
    ..n = 788; 83% African American), 206 genetic variants across the mGluR-eEF2-AMPAR pathway (including GRM1, GRM5, HOMER1, HOMER2, EEF2K, MTOR, EIF4E, EEF2, CAMK2A, ARC, GRIA1 and GRIA4) were found to predict number of drinking days per ..
  6. Ryskamp D, Wu J, Geva M, Kusko R, Grossman I, Hayden M, et al. The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease. Neurobiol Dis. 2017;97:46-59 pubmed publisher
    ..Pridopidine elevated striatal expression of calbindin and homer1a, whereas their striatal expression was reduced in aged Q175KI and YAC128 HD mouse models compared to WT...
  7. Tucsek Z, Noa Valcarcel Ares M, Tarantini S, Yabluchanskiy A, Fulop G, Gautam T, et al. Hypertension-induced synapse loss and impairment in synaptic plasticity in the mouse hippocampus mimics the aging phenotype: implications for the pathogenesis of vascular cognitive impairment. GeroScience. 2017;39:385-406 pubmed publisher
    ..mRNA expression of several genes involved in regulation of neuronal function, including down-regulation of Bdnf, Homer1, and Dlg4, which may have a role in impaired synaptic plasticity...
  8. Alter D, Beverley J, Patel R, Bolaños Guzmán C, Steiner H. The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: Differential effects on immediate-early genes. J Psychopharmacol. 2017;31:1078-1087 pubmed publisher
    ..effects of a selective 5-HT1B receptor agonist (CP94253) on immediate-early gene markers ( Zif268, c- Fos, Homer1a) in adolescent male rats. Gene expression was measured by in situ hybridization histochemistry...
  9. Calabrò M, Mandelli L, Crisafulli C, Lee S, Jun T, Wang S, et al. Neuroplasticity, Neurotransmission and Brain-Related Genes in Major Depression and Bipolar Disorder: Focus on Treatment Outcomes in an Asiatic Sample. Adv Ther. 2018;35:1656-1670 pubmed publisher
    ..Some marginal association (uncorrected p < 0.01) was observed for HTR2A, BDNF, CHL1, RORA and HOMER1 SNPs. In secondary analyses, HTR2A (rs643627, p = 0.002) and CHL1 (rs4003413, p = 0...
  10. Karbasforooshan H, Karimi G. The role of SIRT1 in diabetic cardiomyopathy. Biomed Pharmacother. 2017;90:386-392 pubmed publisher
    ..On the other hand, it increases SERCA2a, ERK1/2/Homer1, eNOS, PGC-1α and AMPK. Therefore, SIRT1 attenuate cardiac dysfunction and improve DCP...
  11. Jansen S, Gottschling C, Faissner A, Manahan Vaughan D. Intrinsic cellular and molecular properties of in vivo hippocampal synaptic plasticity are altered in the absence of key synaptic matrix molecules. Hippocampus. 2017;27:920-933 pubmed publisher
    ..3 in KO compared to WT animals. Homer 1a and of the P/Q-type calcium channel, Cav 1.2 were unchanged in KO mice...
  12. Pickering C, Alsiö J, Morud J, Ericson M, Robbins T, Söderpalm B. Ethanol impairment of spontaneous alternation behaviour and associated changes in medial prefrontal glutamatergic gene expression precede putative markers of dependence. Pharmacol Biochem Behav. 2015;132:63-70 pubmed publisher
    ..5g/kg ethanol decreased mRNA expression of brain-derived neurotrophic factor, NMDA NR2A subunit, mGluR8 receptor, Homer1, the glutamate transporters SLC1a1 and SLC1a6 and Srr...
  13. Rossier B. Osmoregulation during Long-Term Fasting in Lungfish and Elephant Seal: Old and New Lessons for the Nephrologist. Nephron. 2016;134:5-9 pubmed publisher
    ..b>Homer W...
  14. Dinçel Y, Oner A, Arıkan Y, Çağlar S, Ozcafer R, Güleç M. Effect of BMI on outcomes of surgical treatment for tibial plateau fractures: A comparative retrospective case series study. Chin J Traumatol. 2018;21:104-108 pubmed publisher
    ..648, 0.831, and 0.327 respectively. Homer-Lemeshow test values were 0.976, 0.998, and 0.362, respectively...
  15. Vail G, Cheng A, Han Y, Zhao T, Du S, Loy M, et al. ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity. J Neurophysiol. 2016;116:201-9 pubmed publisher
    ..revealed that ATM is significantly more closely associated with Piccolo (a presynaptic marker) than with Homer1 (a postsynaptic marker)...
  16. Kirschstein T, Bauer M, Müller L, Rüschenschmidt C, Reitze M, Becker A, et al. Loss of metabotropic glutamate receptor-dependent long-term depression via downregulation of mGluR5 after status epilepticus. J Neurosci. 2007;27:7696-704 pubmed
    ..Additionally, the scaffolding protein Homer that mediates coupling of mGluR5 to downstream signaling cascades was downregulated...
  17. Haas L, Salazar S, Kostylev M, Um J, Kaufman A, Strittmatter S. Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease. Brain. 2016;139:526-46 pubmed publisher
    ..protein associates via transmembrane metabotropic glutamate receptor 5 with the intracellular protein mediators Homer1b/c, calcium/calmodulin-dependent protein kinase II, and the Alzheimer's disease risk gene product protein tyrosine ..
  18. Palmfeldt J, Henningsen K, Eriksen S, Müller H, Wiborg O. Protein biomarkers of susceptibility and resilience to stress in a rat model of depression. Mol Cell Neurosci. 2016;74:87-95 pubmed publisher
    ..The regulated proteins corroborate previous studies on depression regulated proteins; including GFAP, HOMER1 and glutamatergic transmission (vesicular transporter 1, VGLUT1)...
  19. Peng X, Moore M, Mathur A, Zhou Y, Sun H, Gan Y, et al. Plexin C1 deficiency permits synaptotagmin 7-mediated macrophage migration and enhances mammalian lung fibrosis. FASEB J. 2016;30:4056-4070 pubmed
    ..Zhou, Y., Sun, H., Gan, Y., Herazo-Maya, J. D., Kaminski, N., Hu, X., Pan, H., Ryu, C., Osafo-Addo, A., Homer, R. J., Feghali-Bostwick, C., Fares, W. H., Gulati, M., Hu, B., Lee, C.-G., Elias, J. A., Herzog, E. L...
  20. Suzuki T, Kametani K, Guo W, Li W. Protein components of postsynaptic density lattice, a backbone structure for type I excitatory synapses. J Neurochem. 2017;: pubmed publisher
    ..II are major constituents of the PSD lattice, while scaffold proteins such as PSD-95, SAP102, GKAP, Shank1, and Homer, were rather minor components...
  21. Czerniawski J, Guzowski J. Acute neuroinflammation impairs context discrimination memory and disrupts pattern separation processes in hippocampus. J Neurosci. 2014;34:12470-80 pubmed publisher
    ..The impact of neuroinflammation on hippocampal CA3 and CA1 neural circuit activity was assessed using the Arc/Homer1a cellular analysis of temporal activity by fluorescence in situ hybridization imaging method...
  22. Wen X, Chen X, Chen S, Tan Y, Rong F, Zhu J, et al. Influence of SKF38393 on changes of gene profile in rat prefrontal cortex during chronic paradoxical sleep deprivation. Behav Brain Res. 2016;304:60-6 pubmed publisher
    ..Two transcripts can be specifically reversed with SKF38393, one of them is Homer1, which is related to 20 functional classifications and coding for Glutamatergic synapse pathway...
  23. Inoue Y, Kamikubo Y, Ezure H, Ito J, Kato Y, Moriyama H, et al. Presynaptic protein Synaptotagmin1 regulates the neuronal polarity and axon differentiation in cultured hippocampal neurons. BMC Neurosci. 2015;16:92 pubmed publisher
    ..led to the formation of multiple axons and induced an increase in the number of endogenous postsynaptic protein Homer1c clusters in cultured hippocampal neurons...
  24. Manohar S, Ramchander P, Salvi R, Seigel G. Synaptic Reorganization Response in the Cochlear Nucleus Following Intense Noise Exposure. Neuroscience. 2019;399:184-198 pubmed publisher
    ..We confirmed the PCR findings by in situ hybridization for Brain-derived neurotrophic factor (Bdnf), Homer-1, as well as the glutamate NMDA receptor Grin1, all involved in neurogenesis and plasticity...
  25. Matsushita Y, Sakai Y, Shimmura M, Shigeto H, Nishio M, Akamine S, et al. Hyperactive mTOR signals in the proopiomelanocortin-expressing hippocampal neurons cause age-dependent epilepsy and premature death in mice. Sci Rep. 2016;6:22991 pubmed publisher
    ..hypertrophy of the dentate gyrus (DG) with increased expressions of excitatory synaptic markers (Psd95, Shank3 and Homer). In contrast, the expression of inhibitory neurons (Gad67) was decreased at 6-8 weeks of age...
  26. Haegeli L, Stutz L, Mohsen M, Wolber T, Brunckhorst C, On C, et al. Feasibility of zero or near zero fluoroscopy during catheter ablation procedures. Cardiol J. 2018;: pubmed publisher
    ..When fluoroscopy was required, it was limited to TSP hence keeping the radiation dose very low. . ..
  27. Poplawski S, Peixoto L, Porcari G, Wimmer M, McNally A, Mizuno K, et al. Contextual fear conditioning induces differential alternative splicing. Neurobiol Learn Mem. 2016;134 Pt B:221-35 pubmed publisher
    ..Our work reveals that a short variant of Homer1, Ania-3, is regulated by contextual fear conditioning...
  28. Joffe M, Santiago C, Stansley B, Maksymetz J, Gogliotti R, Engers J, et al. Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress. Neuropharmacology. 2019;144:19-28 pubmed publisher
    ..mGlu5 function were not disrupted following stress; however, signaling downstream of mGlu5-Homer interactions, phosphoinositide-3-kinase (PI3K), Akt, and glycogen synthase kinase 3β was implicated in these ..
  29. JARAMILLO T, Speed H, Xuan Z, Reimers J, Liu S, Powell C. Altered Striatal Synaptic Function and Abnormal Behaviour in Shank3 Exon4-9 Deletion Mouse Model of Autism. Autism Res. 2016;9:350-75 pubmed publisher
    ..Analysis of synaptosome fractions from striata of Shank3(e4-9) KO mice reveals decreased Homer1b/c, GluA2, and GluA3 expression...
  30. Suryavanshi P, Gupta S, Yadav R, Kesherwani V, Liu J, Dravid S. Glutamate Delta-1 Receptor Regulates Metabotropic Glutamate Receptor 5 Signaling in the Hippocampus. Mol Pharmacol. 2016;90:96-105 pubmed publisher
    ..The interaction of mGlu5 with scaffold protein effector Homer, which regulates mechanistic target of rapamycin (mTOR) signaling, was abnormal both under basal conditions and in ..
  31. Tchantchou F, Puche A, Leiste U, Fourney W, Blanpied T, Fiskum G. Rat Model of Brain Injury to Occupants of Vehicles Targeted by Land Mines: Mitigation by Elastomeric Frame Designs. J Neurotrauma. 2018;35:1192-1203 pubmed publisher
    ..Blast exposure reduced hippocampal levels of synaptic proteins Bassoon and Homer-1, which were associated with impaired performance in the Y maze and the Plus maze tests...
  32. Roche K, Tu J, Petralia R, Xiao B, Wenthold R, Worley P. Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. J Biol Chem. 1999;274:25953-7 pubmed
    ..In the present study, we demonstrate that Homer 1b (H1b), a constitutively expressed splice form of the immediate early gene product Homer (now termed Homer 1a) ..
  33. Wills T, Baucum A, Holleran K, Chen Y, Pasek J, Delpire E, et al. Chronic intermittent alcohol disrupts the GluN2B-associated proteome and specifically regulates group I mGlu receptor-dependent long-term depression. Addict Biol. 2017;22:275-290 pubmed publisher
    ..glutamate (mGlu)1/5 receptor-dependent long-term depression (LTD)-associated proteins such as Arc and Homer 1 was increased, while GluA2 was decreased...
  34. Mion M. From "Circe's Root" to "Spongia Soporifera": The Role of the Mandrake as True Anesthetic of Ancient Times. J Anesth Hist. 2017;3:128-133 pubmed publisher
    Several ancient authors cited mandrake as a powerful and well-known narcotic drug: from Homer to Dioscorides, from Plato to Aristotle, passing from Hippocrates, Demosthenes, Theophrastus, Celsus, and Apuleius...
  35. Westhoff J, Hwang S, Duncan R, Ozawa F, Volpe P, Inokuchi K, et al. Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling. Cell Calcium. 2003;34:261-9 pubmed
    ..types of ion channels are physically linked by Vesl (VASP/Ena-related gene up-regulated during seizure and LTP)/Homer proteins [Curr. Opin. Neurobiol. 10 (2000) 370; Trends Neurosci. 23 (2000) 80; J. Cell Sci. 113 (2000) 1851]...
  36. Wilkinson F, Holley R, Langford Smith K, Badrinath S, Liao A, Langford Smith A, et al. Neuropathology in mouse models of mucopolysaccharidosis type I, IIIA and IIIB. PLoS ONE. 2012;7:e35787 pubmed publisher
    ..and mislocalised synaptic vesicle associated membrane protein, (VAMP2), and decreased post-synaptic protein, Homer-1, in layers II/III-VI of the primary motor, somatosensory and parietal cortex...
  37. Kraja A, Borecki I, Tsai M, Ordovas J, Hopkins P, Lai C, et al. Genetic analysis of 16 NMR-lipoprotein fractions in humans, the GOLDN study. Lipids. 2013;48:155-65 pubmed publisher
    ..3), NXPH1 (7p22), and SLC24A4 (14q32.12) in association with NMR-LDLs; HOMER1 (5q14.2), KIT (4q11-q12), VSNL1 (2p24.3), QPRT (16p11.2), SYNPR (3p14.2), NXPH1 (7p22), NELL1 (11p15...
  38. Heinrich A, Müller K, Banaschewski T, Barker G, Bokde A, Bromberg U, et al. Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity. Biol Psychol. 2016;118:79-87 pubmed publisher
    ..However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting ..
  39. Wang F, Zhang Y, Wang L, Sun P, Luo X, Ishigaki Y, et al. Improvement of spatial learning by facilitating large-conductance calcium-activated potassium channel with transcranial magnetic stimulation in Alzheimer's disease model mice. Neuropharmacology. 2015;97:210-9 pubmed publisher
    ..TMS frequency-dependently enhanced the expression of the activity-dependently expressed scaffold protein Homer1a, which turned out to enhance BK channel activity. Isopimaric acid, an activator of the BK channel, magnified LTP...
  40. Marton T, Hussain Shuler M, Worley P. Homer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity. Brain Res. 2015;1628:17-28 pubmed publisher
    ..modulates corticostriatal plasticity through a mechanism involving the induction of the immediate early gene Homer 1a, the phosphorylation of metabotropic glutamate receptor 5 (mGluR5)'s Homer ligand, and the enhancement of an ..
  41. Martinez Monedero R, Liu C, Weisz C, Vyas P, Fuchs P, Glowatzki E. GluA2-Containing AMPA Receptors Distinguish Ribbon-Associated from Ribbonless Afferent Contacts on Rat Cochlear Hair Cells. Eneuro. 2016;3: pubmed publisher
    ..Only half the postsynaptic densities of type II afferents that labeled for PSD-95, Shank, or Homer were associated with GluA2 immunopuncta or presynaptic ribbons, the "empty slots" corresponding to ribbonless ..
  42. Buchtová H, Fajnerová I, Stuchlík A, Kubík Å. Acute systemic MK-801 induced functional uncoupling between hippocampal areas CA3 and CA1 with distant effect in the retrosplenial cortex. Hippocampus. 2017;27:134-144 pubmed publisher
    ..Novel environment exploration triggers expression of immediate-early genes (IEGs) Arc and Homer1a in spatial context-specific ensembles of CA1 and CA3 neurons...
  43. Lagache T, Grassart A, Dallongeville S, Faklaris O, Sauvonnet N, Dufour A, et al. Mapping molecular assemblies with fluorescence microscopy and object-based spatial statistics. Nat Commun. 2018;9:698 pubmed publisher
    ..We show that presynaptic synapsin is arranged in asymmetric triangle with the 2 postsynaptic markers homer and PSD95, indicating a deeper localisation of homer...
  44. Lenka A, Arumugham S, Christopher R, Pal P. Genetic substrates of psychosis in patients with Parkinson's disease: A critical review. J Neurol Sci. 2016;364:33-41 pubmed publisher
    ..E polymorphism followed by polymorphisms in cholecystokinin (CCK) system, dopamine receptors and transporters, HOMER gene, serotonin, catechol-o-methyltransferase, angiotensin converting enzyme and tau...
  45. Zhu M, Zuo J, Shen J, Jing W, Luo P, Li N, et al. Diagnostic Potential of Differentially Expressed Homer1 and Homer2 in Ischemic Stroke. Cell Physiol Biochem. 2016;39:2353-2363 pubmed
    ..RT-qPCR was performed to detect the expression of Homer1, Homer2, and Homer3. We found that the mRNA levels of Homer1 (p<0.001) and Homer2 (p<0...
  46. Kelleher R, Geigenmuller U, Hovhannisyan H, TRAUTMAN E, Pinard R, Rathmell B, et al. High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism. PLoS ONE. 2012;7:e35003 pubmed publisher
    ..In addition, our analysis identified HOMER1, which encodes a postsynaptic density-localized scaffolding protein that interacts with Shank3 to regulate mGluR ..
  47. Jarius S, Wildemann B. 'Medusa-head ataxia': the expanding spectrum of Purkinje cell antibodies in autoimmune cerebellar ataxia. Part 1: Anti-mGluR1, anti-Homer-3, anti-Sj/ITPR1 and anti-CARP VIII. J Neuroinflammation. 2015;12:166 pubmed publisher
    ..Part 1 focuses on anti-metabotropic glutamate receptor 1-, anti-Homer protein homolog 3-, anti-Sj/inositol 1,4,5-trisphosphate receptor- and anti-carbonic anhydrase-related protein ..
  48. Hao X, Plastow G, Zhang C, Xu S, Hu Z, Yang T, et al. Genome-wide association study identifies candidate genes for piglet splay leg syndrome in different populations. BMC Genet. 2017;18:64 pubmed publisher
    ..Four genes (HOMER1 and JMY on SSC2, ITGA1 on SSC16, and RAB32 on SSC1) related to muscle development, glycogen metabolism and ..
  49. de Bartolomeis A, Iasevoli F, Marmo F, Buonaguro E, Avvisati L, Latte G, et al. Nicotine and caffeine modulate haloperidol-induced changes in postsynaptic density transcripts expression: Translational insights in psychosis therapy and treatment resistance. Eur Neuropsychopharmacol. 2018;28:538-559 pubmed publisher
    ..b>Homer1a mRNA expression was significantly reduced by caffeine and nicotine, alone or combined with haloperidol, compared ..
  50. Vicidomini C, Ponzoni L, Lim D, Schmeisser M, Reim D, Morello N, et al. Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice. Mol Psychiatry. 2017;22:689-702 pubmed publisher
    ..that Shank3 is essential to mediating metabotropic glutamate receptor 5 (mGlu5)-receptor signaling by recruiting Homer1b/c to the PSD, specifically in the striatum and cortex...
  51. Volpe P, Sandri C, Bortoloso E, Valle G, Nori A. Topology of Homer 1c and Homer 1a in C2C12 myotubes and transgenic skeletal muscle fibers. Biochem Biophys Res Commun. 2004;316:884-92 pubmed
    ..The subcellular localization of the Homer 1 isoforms was markedly different in transgenic muscle fibers: Homer 1c was diffusely distributed at the I band and ..
  52. Beckley J, Laguesse S, Phamluong K, Morisot N, Wegner S, Ron D. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons. J Neurosci. 2016;36:701-13 pubmed publisher
    ..in NAc shell D1+ neurons and increased synaptic expression of the AMPAR subunit GluA1 and the scaffolding protein Homer. Finally, D1R stimulation alone was sufficient to activate mTORC1 in the NAc to promote mTORC1-dependent ..
  53. Pandya N, Klaassen R, van der Schors R, Slotman J, Houtsmuller A, Smit A, et al. Group 1 metabotropic glutamate receptors 1 and 5 form a protein complex in mouse hippocampus and cortex. Proteomics. 2016;16:2698-2705 pubmed publisher
    ..regions, hippocampus and cortex, and identified mGluR1 as its major interactor in addition to the well described Homer proteins...
  54. Clifton N, Cameron D, Trent S, Sykes L, Thomas K, Hall J. Hippocampal Regulation of Postsynaptic Density Homer1 by Associative Learning. Neural Plast. 2017;2017:5959182 pubmed publisher
    ..The activity-induced expression of short Homer1 isoforms, Homer1a and Ania-3, is thought to be related to processes of learning and memory...
  55. Jansone B, Kadish I, van Groen T, Beitnere U, Moore D, Plotniece A, et al. A Novel 1,4-Dihydropyridine Derivative Improves Spatial Learning and Memory and Modifies Brain Protein Expression in Wild Type and Transgenic APPSweDI Mice. PLoS ONE. 2015;10:e0127686 pubmed publisher
    ..induce anxiolytic action in transgenic mice, and increase expression of hippocampal and cortical proteins (GAD67, Homer-1) related to synaptic plasticity...
  56. Stiber J, Wu J, Zhang L, Nepliouev I, Zhang Z, Bryson V, et al. The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol. 2016;36:984-93 pubmed publisher
    ..Proper function of multiple subfamily C TRP (TRPC) channels requires the scaffolding protein Homer 1, which associates with the actin-binding protein Drebrin...
  57. Wang X, Bey A, Katz B, Badea A, Kim N, David L, et al. Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. Nat Commun. 2016;7:11459 pubmed publisher
    ..Both mGluR5-Homer scaffolds and mGluR5-mediated signalling are selectively altered in striatal neurons...
  58. Lu J, Gan J, Fu G, Ding L, Zheng Q. The Impact of Small RNA Interference Against Homer1 on Rats with Type 2 Diabetes and ERK Phosphorylation. Cell Biochem Biophys. 2015;73:597-601 pubmed publisher
    The objective of the study is to evaluate Homer1 expression in rats with Type 2 diabetes mellitus (T2DM) and investigate the mechanism by which Homer1 influences the pathogenesis of diabetes through study on rat model with decreased ..
  59. Diering G, Nirujogi R, Roth R, Worley P, Pandey A, Huganir R. Homer1a drives homeostatic scaling-down of excitatory synapses during sleep. Science. 2017;355:511-515 pubmed publisher
    ..These changes are driven by the immediate early gene Homer1a and signaling from group I metabotropic glutamate receptors mGluR1/5...
  60. Ni Q, Chen B, Dong S, Tian L, Bai Q. Preparation of core-shell structure Fe3 O4 @SiO2 superparamagnetic microspheres immoblized with iminodiacetic acid as immobilized metal ion affinity adsorbents for His-tag protein purification. Biomed Chromatogr. 2016;30:566-73 pubmed publisher
    ..microspheres were successfully applied for selective enrichment lysozyme from egg white and His-tag recombinant Homer 1a from the inclusion extraction expressed in Escherichia coli...
  61. Sun M, Sun T, He Z, Xiong B. Identification of two novel biomarkers of rectal carcinoma progression and prognosis via co-expression network analysis. Oncotarget. 2017;8:69594-69609 pubmed publisher
    ..The increased Homer scaffolding protein 2 (HOMER2) expression with the favorable survival prediction efficiency significantly ..
  62. Fallon L, Moreau F, Croft B, Labib N, Gu W, Fon E. Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain. J Biol Chem. 2002;277:486-91 pubmed
    ..These data implicate for the first time a PDZ-mediated interaction between parkin and CASK in neurodegeneration and possibly in ubiquitination of proteins involved in synaptic transmission and plasticity. ..
  63. Preuss U, Ridinger M, Rujescu D, Fehr C, Koller G, Wodarz N, et al. No association of alcohol dependence with HOMER 1 and 2 genetic variants. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1102-9 pubmed publisher
    ..b>HOMER 1 and 2 have been reported to contribute to chronic alcohol-induced long-term neurochemical changes in the ..
  64. Jansone B, Kadish I, van Groen T, Beitnere U, Plotniece A, Pajuste K, et al. Memory-enhancing and brain protein expression-stimulating effects of novel calcium antagonist in Alzheimer's disease transgenic female mice. Pharmacol Res. 2016;113:781-787 pubmed publisher
    ..In both female and male mice, AP-12 did not change the expression of hippocampal Homer-1, a protein which is involved in synaptic plasticity...
  65. Rong R, Ahn J, Huang H, Nagata E, Kalman D, Kapp J, et al. PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. Nat Neurosci. 2003;6:1153-61 pubmed
    ..We demonstrate physiologic binding of PIKE-L to Homer, an adaptor protein known to link metabotropic glutamate receptors to multiple intracellular targets including the ..
  66. Lozada L, Desai A, Kevala K, Lee J, Kim H. Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice. J Nutr. 2017;147:1624-1630 pubmed publisher
    ..pups also had decreased hippocampal expression of postsynaptic density protein 95 (43% of Adeq group), Homer protein homolog 1 (21% of Adeq group), and synaptosome-associated protein of 25 kDa (64% of Adeq group)...
  67. Dahl J, Kampman K, Oslin D, Weller A, Lohoff F, Ferraro T, et al. Association of a polymorphism in the Homer1 gene with cocaine dependence in an African American population. Psychiatr Genet. 2005;15:277-83 pubmed
    ..The purpose of this study is to determine whether single-nucleotide polymorphisms in the Homer1 and Homer2 genes associate with the cocaine-dependent phenotype in an African American population...
  68. Shin J, Piya S, Yun C, Seol D, Seo Y, Moon A, et al. Homer1 regulates the susceptibility to TRAIL. Exp Cell Res. 2009;315:2249-55 pubmed publisher
    ..Here we showed that scaffolding protein Homer1 plays a decisive role in regulating the apoptotic susceptibility to TRAIL...
  69. Wu S, Yu M, Li X, Xu S, Shen J, Sun Z, et al. Identification of Homer1 as a potential prognostic marker for intrahepatic cholangiocarcinoma. Asian Pac J Cancer Prev. 2014;15:3299-304 pubmed
    The aim of the present study was to analyze whether Homer1 is a potential prognostic marker for intrahepatic cholangiocarcinoma (ICC)...
  70. Kojima N. Molecular Cloning of Drebrin: Progress and Perspectives. Adv Exp Med Biol. 2017;1006:25-36 pubmed publisher
    ..Besides the ADF-H domain, drebrin has other domains, including the actin-binding domain and Homer-binding motifs...
  71. Aloisi E, Le Corf K, Dupuis J, Zhang P, Ginger M, Labrousse V, et al. Altered surface mGluR5 dynamics provoke synaptic NMDAR dysfunction and cognitive defects in Fmr1 knockout mice. Nat Commun. 2017;8:1103 pubmed publisher
    ..These synaptic and behavioral phenomena were reversed by knocking down Homer1a in Fmr1 KO mice...
  72. Salanova M, Bortoloso E, Schiffl G, Gutsmann M, Belavy D, Felsenberg D, et al. Expression and regulation of Homer in human skeletal muscle during neuromuscular junction adaptation to disuse and exercise. FASEB J. 2011;25:4312-25 pubmed publisher
    Protein calcium sensors of the Homer family have been proposed to modulate the activity of various ion channels and nuclear factor of activated T cells (NFAT), the transcription factor modulating skeletal muscle differentiation...
  73. Li R, Liu W, Lin Y, Zhao H, Zhang C. An Ensemble Multilabel Classification for Disease Risk Prediction. J Healthc Eng. 2017;2017:8051673 pubmed publisher
    ..Moreover, the comparison between ELPPJD and the classic multilabel classification methods RAkEL and HOMER is carried out...
  74. Schreiner D, Müller K, Hofer H. The intracellular domain of the human protocadherin hFat1 interacts with Homer signalling scaffolding proteins. FEBS Lett. 2006;580:5295-300 pubmed
    ..Here we demonstrate that: (i) the scaffolding proteins Homer-3 and Homer-1 also interact with the EVH1 binding site of hFat1 in vitro, and (ii) binding of Homer-3 and Mena to ..
  75. Wu S, Gan G, Zhang Z, Sun J, Wang Q, Gao Z, et al. A Presynaptic Function of Shank Protein in Drosophila. J Neurosci. 2017;37:11592-11604 pubmed publisher
    ..Specifically, Shank coexpressed with another PSD scaffold protein, Homer, in the calyx of mushroom bodies in the brain...
  76. Norton N, Williams H, Williams N, Spurlock G, Zammit S, Jones G, et al. Mutation screening of the Homer gene family and association analysis in schizophrenia. Am J Med Genet B Neuropsychiatr Genet. 2003;120B:18-21 pubmed
    ..Only one (Homer 1 IVS4 + 18A > G) was associated with schizophrenia in this sample, a finding confirmed by individual genotyping ..
  77. Hu J, Park J, Park S, Xiao B, Dehoff M, Kim S, et al. Homeostatic scaling requires group I mGluR activation mediated by Homer1a. Neuron. 2010;68:1128-42 pubmed publisher
    ..is dependent on group I metabotropic glutamate receptor activation that is mediated by the immediate early gene Homer1a. Homer1a is transiently upregulated during increases in network activity and evokes agonist-independent signaling ..
  78. Hayashi K. Cell Shape Change by Drebrin. Adv Exp Med Biol. 2017;1006:83-101 pubmed publisher
    ..Furthermore, drebrin binds to various molecules, such as homer, EB3, and cell-cell junctional proteins, indicating that drebrin is a multifunctional cytoskeletal regulator.
  79. Yamazaki H, Shirao T. Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain. Adv Exp Med Biol. 2017;1006:249-268 pubmed publisher
    ..In this chapter, we will first review the interaction of Homer and spikar with drebrin, particularly focusing on spine morphogenesis and synaptic function...
  80. Ango F, Prezeau L, Muller T, Tu J, Xiao B, Worley P, et al. Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer. Nature. 2001;411:962-5 pubmed
    ..Disruption of this interaction by mutagenesis or antisense strategies, or expression of endogenous Homer1a (H1a), induces constitutive activity in mGluR1a or mGluR5...
  81. De Luca V, Annesi G, De Marco E, de Bartolomeis A, Nicoletti G, Pugliese P, et al. HOMER1 promoter analysis in Parkinson's disease: association study with psychotic symptoms. Neuropsychobiology. 2009;59:239-45 pubmed publisher
    b>HOMER1 gene expression has been linked to abnormal movements in animals receiving chronic administration of antipsychotics...
  82. Spellmann I, Rujescu D, Musil R, Mayr A, Giegling I, Genius J, et al. Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients. J Psychiatr Res. 2011;45:234-41 pubmed publisher
    The HOMER 1 protein plays a crucial role in mediating glutamatergic neurotransmission. It has previously shown to be a candidate gene for etiology and pathophysiology of different psychiatric diseases such as schizophrenia...
  83. Tang J, Zhou H, Wang C, Fei X, Zhu L, Huang Y, et al. Cell adhesion downregulates the expression of Homer1b/c and contributes to drug resistance in multiple myeloma cells. Oncol Rep. 2016;35:1875-83 pubmed publisher
    Previous studies have demonstrated that Homer1b/c plays an important pro-apoptotic role through classical mitochondrial apoptotic pathway...
  84. Shalygin A, Ryazantseva M, Glushankova L, Mozhayeva G, Bezprozvanny I, Kaznacheyeva E. Homer regulation of native plasma membrane calcium channels in A431 cells. Cell Calcium. 2010;48:209-14 pubmed publisher
    ..Previous functional studies linked Homer proteins to calcium influx in nonexcitable cells...
  85. Jing X, Chen S, Jing W, Tan Q, Yu M, Tu J. Diagnostic potential of differentially expressed Homer1, IL-1β, and TNF-α in coronary artery disease. Int J Mol Sci. 2014;16:535-46 pubmed publisher
    ..The study was carried out on 163 CAD patients at different stages and 68 controls. The gene expression of Homer1, Homer2, Homer3, IL-1β, and TNF-α in the peripheral blood leukocytes were measured by real-time polymerase ..
  86. Leber S, Llenos I, Miller C, Dulay J, Haybaeck J, Weis S. Homer1a protein expression in schizophrenia, bipolar disorder, and major depression. J Neural Transm (Vienna). 2017;124:1261-1273 pubmed publisher
    ..The present study aims to compare Homer1a expression in the hippocampus and cingulate gyrus of patients with major psychiatric disorders including ..
  87. Bavencoffe A, Zhu M, Tian J. New Aspects of the Contribution of ER to SOCE Regulation: TRPC Proteins as a Link Between Plasma Membrane Ion Transport and Intracellular Ca2+ Stores. Adv Exp Med Biol. 2017;993:239-255 pubmed publisher
    ..the intracellular Ca2+ store contents, such as inositol trisphosphate receptors, Junctate, and Homer, further argues for the role of TRPC proteins in linking plasma membrane ion transport with intracellular Ca2+..
  88. Luo P, Li X, Fei Z, Poon W. Scaffold protein Homer 1: implications for neurological diseases. Neurochem Int. 2012;61:731-8 pubmed publisher
    Homer proteins are commonly known as scaffold proteins at postsynaptic density. Homer 1 is a widely studied member of the Homer protein family, comprising both synaptic structure and mediating postsynaptic signaling transduction...
  89. Goulding S, Szumlinski K, Contet C, MacCoss M, Wu C. A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain. J Proteomics. 2017;166:127-137 pubmed publisher
    In the brain, the Homer protein family modulates excitatory signal transduction and receptor plasticity through interactions with other proteins in dendritic spines...
  90. Suzuki T, Li W, Zhang J, Tian Q, Sakagami H, Usuda N, et al. A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins. Eur J Neurosci. 2005;21:339-50 pubmed
    ..Pull-down experiments showed that TANC protein bound PSD-95, SAP97, and Homer via its C-terminal PDZ-binding motif, -ESNV, and fodrin via both its ankyrin repeats and the TPRs together with ..
  91. Dionisio N, Smani T, Woodard G, Castellano A, Salido G, Rosado J. Homer proteins mediate the interaction between STIM1 and Cav1.2 channels. Biochim Biophys Acta. 2015;1853:1145-53 pubmed publisher
    ..Treatment with TG induces co-immunoprecipitation of Homer1 with STIM1 and the Cav1.2 α1 subunit...
  92. May R. Custom-Made Quorum Sensing for a Eukaryote. Dev Cell. 2016;37:391-2 pubmed publisher
    ..Reporting recently in Cell Host & Microbe, Homer et al...