homeodomain interacting protein kinase 1


Gene Symbol: homeodomain interacting protein kinase 1
Description: homeodomain interacting protein kinase 1
Alias: Myak, Nbak2, homeodomain-interacting protein kinase 1, homeodomain interacting protein kinase 1-like protein, nuclear body associated kinase 2b, nuclear body-associated kinase 2
Species: human

Top Publications

  1. Song J, Lee Y. Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. J Biol Chem. 2003;278:47245-52 pubmed
    ..The relocalized Daxx may play an important role in glucose deprivation-induced ASK1 oligomerization. ..
  2. Inoue T, Kagawa T, Inoue Mochita M, Isono K, Ohtsu N, Nobuhisa I, et al. Involvement of the Hipk family in regulation of eyeball size, lens formation and retinal morphogenesis. FEBS Lett. 2010;584:3233-8 pubmed publisher
    ..These data indicate that Hipk1 and Hipk2 are involved in regulation of eye size, lens formation and retinal lamination during late embryogenesis. ..
  3. Ritter O, Schmitz M. Differential intracellular localization and dynamic nucleocytoplasmic shuttling of homeodomain-interacting protein kinase family members. Biochim Biophys Acta Mol Cell Res. 2019;: pubmed publisher
  4. Lin X, Kulkarni P, Bocci F, Schafer N, Roy S, Tsai M, et al. Structural and Dynamical Order of a Disordered Protein: Molecular Insights into Conformational Switching of PAGE4 at the Systems Level. Biomolecules. 2019;9: pubmed publisher
  5. Nagao Y, Mimura N, Takeda J, Yoshida K, Shiozawa Y, Oshima M, et al. Genetic and transcriptional landscape of plasma cells in POEMS syndrome. Leukemia. 2019;: pubmed publisher
    ..Our study illustrates that the genetic and transcriptional profiles of plasma cells in POEMS syndrome are distinct from MM and MGUS, indicating unique function of clonal plasma cells in its pathogenesis. ..
  6. Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, et al. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metab. 2015;21:584-95 pubmed publisher
    ..These studies implicate miR-222 as necessary for exercise-induced cardiomyocyte growth and proliferation in the adult mammalian heart and show that it is sufficient to protect the heart against adverse remodeling. ..
  7. Ohnheiser J, Ferlemann E, Haas A, Müller J, Werwein E, Fehler O, et al. Programmed cell death 4 protein (Pdcd4) and homeodomain-interacting protein kinase 2 (Hipk2) antagonistically control translation of Hipk2 mRNA. Biochim Biophys Acta. 2015;1853:1564-73 pubmed publisher
    ..Furthermore, the effect of Hipk2 on the translation of Hipk1 RNA suggests that Hipk2 and Pdcd4 can act in similar manner to control the translation of other mRNAs. ..
  8. Akaike Y, Kuwano Y, Nishida K, Kurokawa K, Kajita K, Kano S, et al. Homeodomain-interacting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1γ. Oncogene. 2015;34:3463-73 pubmed publisher
    ..This HIPK2/HP1γ pathway may uncover a new functional aspect of HIPK2 as a tumor suppressor. ..
  9. Mattingsdal M, Jentoft S, Tørresen O, Knutsen H, Hansen M, Robalo J, et al. A continuous genome assembly of the corkwing wrasse (Symphodus melops). Genomics. 2018;110:399-403 pubmed publisher
    ..This new genomic resource, together with the ballan wrasse (Labrus bergylta), will allow for in-depth comparative genomics as well as population genetic analyses for the understudied wrasses. ..

More Information


  1. Lin X, Roy S, Jolly M, Bocci F, Schafer N, Tsai M, et al. PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer. J Mol Biol. 2018;430:2422-2438 pubmed publisher
    ..Thus, conformational switching of PAGE4 may potentially affect the efficiency of therapeutically targeting AR activity. ..
  2. Rodriguez Gil A, Ritter O, Hornung J, Stekman H, Kruger M, Braun T, et al. HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell. 2016;27:1969-80 pubmed publisher
    ..HIPKs are well known regulators of transcription, but the mutual regulation between CCR4-NOT and HIPKs extends the regulatory potential of these kinases by enabling posttranscriptional gene regulation. ..
  3. Bengtsen M, Sørensen L, Aabel L, Ledsaak M, Matre V, Gabrielsen O. The adaptor protein ARA55 and the nuclear kinase HIPK1 assist c-Myb in recruiting p300 to chromatin. Biochim Biophys Acta Gene Regul Mech. 2017;1860:751-760 pubmed publisher
    ..We propose that ARA55 and HIPK1 assist c-Myb in recruiting the coactivator and acetyltransferase p300 to chromatin. ..
  4. Hashimoto K, Tsuji Y. Arsenic-Induced Activation of the Homeodomain-Interacting Protein Kinase 2 (HIPK2) to cAMP-Response Element Binding Protein (CREB) Axis. J Mol Biol. 2017;429:64-78 pubmed publisher
    ..These results suggest that the HIPK2-phospho-Ser271 CREB axis is a new arsenic-responsive CREB activation mechanism in parallel with the PKA-phospho-Ser133 CREB axis. ..
  5. Glenewinkel F, Cohen M, King C, Kaspar S, Bamberg Lemper S, Mymryk J, et al. The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. Sci Rep. 2016;6:28241 pubmed publisher
    ..Our results characterize DCAF7 as a substrate recruiting subunit of DYRK1A and HIPK2 and suggest that it is required for the negative effect of DYRK1A on E1A-induced oncogenic transformation. ..
  6. Kulkarni P, Jolly M, Jia D, Mooney S, Bhargava A, Kagohara L, et al. Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity. Proc Natl Acad Sci U S A. 2017;114:E2644-E2653 pubmed publisher
  7. Clausse V, Goloudina A, Uyanik B, Kochetkova E, Richaud S, Fedorova O, et al. Wee1 inhibition potentiates Wip1-dependent p53-negative tumor cell death during chemotherapy. Cell Death Dis. 2016;7:e2195 pubmed publisher
    ..The development and clinical use of Wee1 and Hipk1 kinase chemical inhibitors might be a promising strategy to improve anti-cancer therapy. ..
  8. Matre V, Nordgård O, Alm Kristiansen A, Ledsaak M, Gabrielsen O. HIPK1 interacts with c-Myb and modulates its activity through phosphorylation. Biochem Biophys Res Commun. 2009;388:150-4 pubmed publisher
    ..Our findings point to a novel link between an important kinase and a key regulator of haematopoiesis. ..
  9. Rey C, Soubeyran I, Mahouche I, Pedeboscq S, Bessede A, Ichas F, et al. HIPK1 drives p53 activation to limit colorectal cancer cell growth. Cell Cycle. 2013;12:1879-91 pubmed publisher
    HIPK1 (homeodomain interacting protein kinase 1) is a serine/threonine kinase that belongs to the CMGC superfamily...
  10. Inwood S, Buehler E, Betenbaugh M, Lal M, Shiloach J. Identifying HIPK1 as Target of miR-22-3p Enhancing Recombinant Protein Production From HEK 293 Cell by Using Microarray and HTP siRNA Screen. Biotechnol J. 2017;: pubmed publisher
    ..The identified genes were validated as being involved in improving luciferase expression by using siRNA and qRT-PCR. Repressing the target gene, HIPK1, is found to increase luciferase and GPC3 expression 3.3- and 2.2-fold, respectively...
  11. Ecsedy J, Michaelson J, Leder P. Homeodomain-interacting protein kinase 1 modulates Daxx localization, phosphorylation, and transcriptional activity. Mol Cell Biol. 2003;23:950-60 pubmed
    ..Taken together, our results indicate that HIPK1 and Daxx collaborate in regulating transcription. ..
  12. Aikawa Y, Nguyen L, Isono K, Takakura N, Tagata Y, Schmitz M, et al. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. EMBO J. 2006;25:3955-65 pubmed
    ..HIPK2 also phosphorylates another co-activator, MOZ, in an AML1-dependent manner. We discuss a possible mechanism by which transcription factors could regulate local histone acetylation and transcription of their target genes. ..
  13. Park B, Park S, Koo J, Kim S, Park J, Cho J, et al. Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues. Jpn J Clin Oncol. 2012;42:1138-45 pubmed publisher
    ..Although the mechanism is not certain, the subcellular localization of HIPK1 expression is associated with tumor histopathologic characteristics and different functions. ..
  14. Lee D, Park S, Sung K, Park J, Lee S, Park S, et al. Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1. EMBO Rep. 2012;13:163-9 pubmed publisher
    ..These findings indicate that the control of HIPK1 stability by Mdm2-NORE1 has a major effect on cell behaviour, and epigenetic inactivation of NORE1 enables adenocarcinoma formation in vivo through HIPK1 stabilization. ..
  15. Kim S, Choi D, Kim E, Choi C. Stabilization of HIPK2 by escape from proteasomal degradation mediated by the E3 ubiquitin ligase Siah1. Cancer Lett. 2009;279:177-84 pubmed publisher
  16. Kim Y, Choi C, Lee S, Conti M, Kim Y. Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998;273:25875-9 pubmed
    ..Thus, HIPKs represent a heretofore undescribed family of co-repressors for homeodomain transcription factors. ..
  17. Li X, Zhang R, Luo D, Park S, Wang Q, Kim Y, et al. Tumor necrosis factor alpha-induced desumoylation and cytoplasmic translocation of homeodomain-interacting protein kinase 1 are critical for apoptosis signal-regulating kinase 1-JNK/p38 activation. J Biol Chem. 2005;280:15061-70 pubmed
    ..Our study suggests that TNFalpha-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha-induced ASK1-JNK/p38 activation. ..
  18. van der Laden J, Soppa U, Becker W. Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK). Cell Commun Signal. 2015;13:3 pubmed publisher
    ..However, members of the HIPK family differ regarding the subcellular localization and its dependence on tyrosine autophosphorylation. ..
  19. Mooney S, Qiu R, Kim J, Sacho E, Rajagopalan K, Johng D, et al. Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway. Biochemistry. 2014;53:1670-9 pubmed publisher
    ..Regardless, the present results clearly implicate PAGE4 as a component of the stress-response pathway and uncover a novel link between components of this pathway and prostatic development and disease. ..
  20. Sekito A, Koide Yoshida S, Niki T, Taira T, Iguchi Ariga S, Ariga H. DJ-1 interacts with HIPK1 and affects H2O2-induced cell death. Free Radic Res. 2006;40:155-65 pubmed
  21. Hattangadi S, Burke K, Lodish H. Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation. Blood. 2010;115:4853-61 pubmed publisher
  22. Kondo S, Lu Y, Debbas M, Lin A, Sarosi I, Itie A, et al. Characterization of cells and gene-targeted mice deficient for the p53-binding kinase homeodomain-interacting protein kinase 1 (HIPK1). Proc Natl Acad Sci U S A. 2003;100:5431-6 pubmed
    ..Carcinogen-treated HIPK1 -/- mice developed fewer and smaller skin tumors than HIPK1+/+ mice. HIPK1 may thus play a role in tumorigenesis, perhaps by means of the regulation of p53 and/or Mdm2. ..