homeobox

Summary

Gene Symbol: homeobox
Description: ladybird homeobox 1
Alias: HPX-6, HPX6, LBX1H, homeobox, transcription factor LBX1, lady bird-like homeobox, ladybird homeobox homolog 1, ladybird homeobox protein homolog 1, transcription factor similar to D. melanogaster homeodomain protein lady bird late
Species: human
Products:     homeobox

Top Publications

  1. Jagla K, Dolle P, Mattei M, Jagla T, Schuhbaur B, Dretzen G, et al. Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes. Mech Dev. 1995;53:345-56 pubmed
    We have cloned two novel homeobox genes which are the mouse (Lbx1) and human (LBX1) homologs of the Drosophila lady bird genes. They are highly related not only within the coding region but also in 5' and 3' untranslated regions...
  2. Gao W, Peng Y, Liang G, Liang A, Ye W, Zhang L, et al. Association between common variants near LBX1 and adolescent idiopathic scoliosis replicated in the Chinese Han population. PLoS ONE. 2013;8:e53234 pubmed publisher
    ..This study shows that the genetic variants near the LBX1 gene are associated with AIS susceptibility in Chinese Han population. It successfully replicates the results of the GWAS, which was performed in a Japanese population. ..
  3. Londono D, Kou I, Johnson T, Sharma S, Ogura Y, Tsunoda T, et al. A meta-analysis identifies adolescent idiopathic scoliosis association with LBX1 locus in multiple ethnic groups. J Med Genet. 2014;51:401-6 pubmed publisher
    ..The LBX1 protein, a homeobox transcription factor that is orthologous to the Drosophila ladybird late gene, is involved in proper migration of ..
  4. Fan Y, Song Y, Chan D, Takahashi Y, Ikegawa S, Matsumoto M, et al. SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese. J Hum Genet. 2012;57:244-6 pubmed publisher
    ..We employed case-control analysis to study the association of SNP rs11190870 near LBX1 (ladybird homeobox 1) with AIS in a southern Chinese population...
  5. Jiang H, Qiu X, Dai J, Yan H, Zhu Z, Qian B, et al. Association of rs11190870 near LBX1 with adolescent idiopathic scoliosis susceptibility in a Han Chinese population. Eur Spine J. 2013;22:282-6 pubmed publisher
    ..005). The meta-analysis confirmed that the positive association of this SNP with AIS in the East Asian population. The SNP rs11190870 near LBX1 is associated with both susceptibility and curve progression of AIS. ..
  6. Takahashi Y, Kou I, Takahashi A, Johnson T, Kono K, Kawakami N, et al. A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis. Nat Genet. 2011;43:1237-40 pubmed publisher
    ..24 × 10(-19); odds ratio (OR) = 1.56) is located near LBX1 (encoding ladybird homeobox 1)...
  7. Setiawan M, Tan X, Goh T, Hin Fai Yam G, Mehta J. Inhibiting glycogen synthase kinase-3 and transforming growth factor-? signaling to promote epithelial transition of human adipose mesenchymal stem cells. Biochem Biophys Res Commun. 2017;490:1381-1388 pubmed publisher
    ..transition was shown by down-regulation of mesenchymal genes (Slug, Zinc Finger E-box Binding Homeobox 1 ZEB1, integrin ?5 ITGA5 and vimentin VIM) and up-regulation of epithelial genes (E-cadherin, Epithelial Cell ..
  8. Kameyama H, Udagawa O, Hoshi T, Toukairin Y, Arai T, Nogami M. The mRNA expressions and immunohistochemistry of factors involved in angiogenesis and lymphangiogenesis in the early stage of rat skin incision wounds. Leg Med (Tokyo). 2015;17:255-60 pubmed publisher
    ..growth factor 2 (FGF 2), c-fos induced growth factor (FIGF/VEGF-D), forkhead box C2 (FOXC2), and prospero homeobox 1 (PROX1) were also studied...
  9. Chen G, Yang X, Yang X, Li L, Luo J, Dong H, et al. Jia-Wei-Jiao-Tai-Wan ameliorates type 2 diabetes by improving ? cell function and reducing insulin resistance in diabetic rats. BMC Complement Altern Med. 2017;17:507 pubmed publisher
    ..the oxidative stress in the pancreata of diabetic rats, and the expression levels of pancreatic and duodenal homeobox 1 (PDX-1) and insulin in the pancreas were tested by Western blot to measure pancreatic islet function...

More Information

Publications141 found, 100 shown here

  1. Zhang Y, Feng F, Chen T, Li Z, Shen Q. Antidiabetic and antihyperlipidemic activities of Forsythia suspensa (Thunb.) Vahl (fruit) in streptozotocin-induced diabetes mice. J Ethnopharmacol. 2016;192:256-263 pubmed publisher
    ..carboxykinase) in liver and insulin secretion related genes insulin-1, insulin-2 and duodenal homeobox factor-1 in pancreas. The ethyl acetate extract of Forsythia suspense (Thunb...
  2. Li R, Wu J, He J, Wang Y, Liu X, Chen X, et al. Mice endometrium receptivity in early pregnancy is impaired by maternal hyperinsulinemia. Mol Med Rep. 2017;15:2503-2510 pubmed publisher
    ..However, the expression levels of estrogen receptor (Esr) 1, Esr2, progesterone receptor and homeobox A10 associated with endometrial receptivity, were imbalanced during endometrium receptivity when maternal ..
  3. Vizziano Cantonnet D, Lasalle A, Di Landro S, Klopp C, Genthon C. De novo transcriptome analysis to search for sex-differentiation genes in the Siberian sturgeon. Gen Comp Endocrinol. 2018;: pubmed publisher
    ..the somatic cells, provide architectural support for the stem-cell niche; and (3) mitogenic factors, such as lim homeobox 2, amphiregulin, G2/M phase-specific E3 ubiquitin-protein ligase, and connector enhancer of kinase suppressor of ..
  4. Song Y, Liu C, Liu X, Trottier J, Beaudoin M, Zhang L, et al. H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of epithelial cell adhesion molecule. Hepatology. 2017;66:1183-1196 pubmed publisher
    ..H19 down-regulated hepatic zinc finger E-box-binding homeobox 1 (ZEB1) but up-regulated epithelial cell adhesion molecule (EpCAM) and SRY (sex determining region Y)-box 9 ..
  5. Kaushansky A, Kaushansky K. Systems biology of megakaryocytes. Adv Exp Med Biol. 2014;844:59-84 pubmed publisher
    ..Rac1, Rho, and CDC42; several transcription factors, including hypoxia-inducible factor 1α(alpha), the homeobox-containing proteins HOXB4 and HOXA9, and a number of signaling mediators that are reduced, including glycogen ..
  6. Doh S, Yamakawa M, Santosa S, Montaña M, Guo K, Sauer J, et al. Fluorescent reporter transgenic mice for in vivo live imaging of angiogenesis and lymphangiogenesis. Angiogenesis. 2018;: pubmed publisher
    ..other fluorescent proteins can be expressed under control of a lymphatic-specific marker like Prospero-related homeobox 1 (Prox1), which is a highly conserved transcription factor for determining embryonic organogenesis in ..
  7. Qureshi A, Khan D, Mushtaq S, Ye S, Xiong M, Qureshi N. ?-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients. Lipids Health Dis. 2018;17:167 pubmed publisher
    ..The gene expression of transcription regulators (ceramide synthase 3 and Mohawk homeobox) were up-regulated, and gene expression of 208 molecules were down-regulated, involved in several biological ..
  8. Huang J, Wu J, Xiang S, Sheng S, Jiang Y, Yang Z, et al. Catalpol preserves neural function and attenuates the pathology of Alzheimer's disease in mice. Mol Med Rep. 2016;13:491-6 pubmed publisher
    ..senile plaques and reverse-transcription quantitative polymerase chain reaction was used to assess iroquois homeobox protein 3 (IRX3) and obesity‑associated genes, while western blot analysis was used for β‑..
  9. Palazzo E, Kellett M, Cataisson C, Bible P, Bhattacharya S, Sun H, et al. A novel DLX3-PKC integrated signaling network drives keratinocyte differentiation. Cell Death Differ. 2017;24:717-730 pubmed publisher
    ..We have recently shown that the homeobox transcription factor DLX3 and the tumor suppressor p53 co-regulate cell cycle-related signaling and that this ..
  10. Li Y, Wang Y, He Q, Dang X, Cao Y, Wu X, et al. Genetic mutational testing of Chinese children with familial hematuria with biopsy?proven FSGS. Mol Med Rep. 2017;: pubmed publisher
    ..potential cation channel subfamily C member 6, inverted formin, FH2 and WH2 domain containing, Wilms tumor 1, LIM homeobox transcription factor 1 ?, laminin subunit ? 2, laminin subunit ? 3, galactosida ?, integrin subunit ? 4, ..
  11. Tian B, Patrikeev I, Ochoa L, Vargas G, Belanger K, Litvinov J, et al. NF-κB Mediates Mesenchymal Transition, Remodeling, and Pulmonary Fibrosis in Response to Chronic Inflammation by Viral RNA Patterns. Am J Respir Cell Mol Biol. 2017;56:506-520 pubmed publisher
    ..enhanced the expression of core mesenchymal regulators Snail family zinc finger 1, zinc finger E-box binding homeobox, mesenchymal intermediate filaments (vimentin), and extracellular matrix proteins (fibronectin-1), and collagen ..
  12. Yong H, Eamsobhana P, Lim P, Razali R, Aziz F, Rosli N, et al. Draft genome of neurotropic nematode parasite Angiostrongylus cantonensis, causative agent of human eosinophilic meningitis. Acta Trop. 2015;148:51-7 pubmed publisher
    ..genome contains 34 excretory-secretory proteins (ES), a minimum of 44 Nematode Astacin (NAS) metalloproteases, 12 Homeobox (HOX) genes, and 30 neurotransmitters...
  13. Xiang Q, Liao Y, Chao H, Huang W, Liu J, Chen H, et al. ISL1 overexpression enhances the survival of transplanted human mesenchymal stem cells in a murine myocardial infarction model. Stem Cell Res Ther. 2018;9:51 pubmed publisher
    The LIM-homeobox transcription factor islet-1 (ISL1) has been proposed as a marker for cardiovascular progenitor cells...
  14. Heo J, Choi Y, Kim H, Kim H. Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med. 2016;37:115-25 pubmed publisher
    ..and differentiation stage-related genes [B4GALNT1 (GM2/GS2 synthase), inhibin, beta A (INHBA), distal-less homeobox 5 (DLX5), runt-related transcription factor 2 (RUNX2), proliferator‑activated receptor gamma (PPARG), ..
  15. Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro Pando S, et al. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. 2018;155:210-223.e3 pubmed publisher
    ..Strategies to disrupt this pathway might be developed to prevent pancreatic tumor growth and progression. ..
  16. Qiu G, Tian W, Huan M, Chen J, Fu H. Formononetin exhibits anti-hyperglycemic activity in alloxan-induced type 1 diabetic mice. Exp Biol Med (Maywood). 2017;242:223-230 pubmed publisher
    ..Fas, Caspase-3, pancreatic and duodenal homeobox-1 , insulin receptor substrate 2, glucokinase and glucose transporter 2, mRNA and proteins levels in pancreas ..
  17. Tapia Pizarro A, Archiles S, Argandoña F, Valencia C, Zavaleta K, Cecilia Johnson M, et al. hCG activates Epac-Erk1/2 signaling regulating Progesterone Receptor expression and function in human endometrial stromal cells. Mol Hum Reprod. 2017;23:393-405 pubmed publisher
    ..decreased the mRNA levels for secreted frizzled-related protein 4 (SFRP4) at 24 h, whereas it increased those for homeobox A10 (HOXA10) at 48 h (P = 0.041 and P = 0.022 versus control, respectively)...
  18. Leng L, Tan Y, Gong F, Hu L, Ouyang Q, Zhao Y, et al. Differentiation of primordial germ cells from induced pluripotent stem cells of primary ovarian insufficiency. Hum Reprod. 2015;30:737-48 pubmed publisher
    ..four factors: octamer-binding transcription factor 4 (OCT4), sex-determining region Y-box 2 (SOX2), Nanog homeobox (NANOG), and lin-28 homolog (LIN28), using lentiviral vectors...
  19. Watanabe Y, Stanchina L, Lecerf L, Gacem N, Conidi A, Baral V, et al. Differentiation of Mouse Enteric Nervous System Progenitor Cells Is Controlled by Endothelin 3 and Requires Regulation of Ednrb by SOX10 and ZEB2. Gastroenterology. 2017;152:1139-1150.e4 pubmed publisher
    ..receptor type B [EDNRB]), and the transcription factors SRY-box 10 (SOX10) and zinc finger E-box binding homeobox 2 (ZEB2)...
  20. Yang L, Liu L, Gao H, Pinnamaneni J, Sanagasetti D, Singh V, et al. The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis. J Hematol Oncol. 2017;10:159 pubmed publisher
    ..Recently, SALL4 has been further linked to the functions of MLL and its target gene homeobox A9 (HOXA9). However, it remains unclear whether SALL4 is indeed a key player in MLL-r leukemia pathogenesis...
  21. Xu Z, Ramachandran S, Gunasekaran M, Zhou F, Trulock E, Kreisel D, et al. MicroRNA-144 dysregulates the transforming growth factor-β signaling cascade and contributes to the development of bronchiolitis obliterans syndrome after human lung transplantation. J Heart Lung Transplant. 2015;34:1154-62 pubmed publisher
    ..Expression of miR-144 and its target, transforming growth factor-β (TGF-β)-induced factor homeobox 1(TGIF1), were analyzed by real-time polymerase chain reaction and Western blot...
  22. Kusuyama J, Kamisono A, ChangHwan S, Amir M, Bandow K, Eiraku N, et al. Spleen tyrosine kinase influences the early stages of multilineage differentiation of bone marrow stromal cell lines by regulating phospholipase C gamma activities. J Cell Physiol. 2017;: pubmed publisher
    ..as well as the expression levels of osteocalcin, runt-related transcription factor 2 (Runx2), and distal-less homeobox 5 (Dlx5) mRNAs...
  23. Lee V, Hosking B, Holeniewska J, Kubala E, Lundh von Leithner P, Gardner P, et al. BTBR ob/ob mouse model of type 2 diabetes exhibits early loss of retinal function and retinal inflammation followed by late vascular changes. Diabetologia. 2018;: pubmed publisher
    ..Animals were weighed and blood glucose was measured. TUNEL and brain-specific homeobox/POU domain protein 3A (BRN3A) markers were used to examine retinal ganglion cells...
  24. Abdul Samad F, Suliman B, Basha S, Manivasagam T, Essa M. A Comprehensive In Silico Analysis on the Structural and Functional Impact of SNPs in the Congenital Heart Defects Associated with NKX2-5 Gene-A Molecular Dynamic Simulation Approach. PLoS ONE. 2016;11:e0153999 pubmed publisher
    ..NKX 2-5 gene is one among them, which encodes a homeobox-containing transcription factor that plays a crucial role during the initial phases of heart formation and ..
  25. Guo C, Wang Q, Wang Y, Yang L, Luo H, Cao X, et al. Exome sequencing reveals novel IRXI mutation in congenital heart disease. Mol Med Rep. 2017;15:3193-3197 pubmed publisher
    ..In addition, a novel non?synonymous mutation of the iroquois homeobox 1 (IRX1) gene (p.Gln240Glu) was identified. A total of three non?synonymous mutations (p.Gln240Glu, p...
  26. King J, Kwan S, Yan J, Klatt K, Jiang X, Roberson M, et al. Maternal Choline Supplementation Alters Fetal Growth Patterns in a Mouse Model of Placental Insufficiency. Nutrients. 2017;9: pubmed publisher
    ..effects of maternal choline supplementation (MCS) on parameters of fetal growth in a Dlx3+/- (distal-less homeobox 3) mouse model of placental insufficiency...
  27. Lee H, Chae S, Park J, Bae J, Go E, Kim S, et al. Comprehensive Proteome Profiling of Platelet Identified a Protein Profile Predictive of Responses to An Antiplatelet Agent Sarpogrelate. Mol Cell Proteomics. 2016;15:3461-3472 pubmed
    ..Based on the network model of the proteins involved in these processes, we selected three proteins (cut-like homeobox 1; coagulation factor XIII, B polypeptide; and peptidylprolyl isomerase D) that reflect the platelet aggregation-..
  28. Wang Y, Wang M, Xia Y, Gao Y, Zhu Y, Chen S, et al. MicroRNA-130a regulates cerebral ischemia-induced blood-brain barrier permeability by targeting Homeobox A5. FASEB J. 2017;: pubmed publisher
    ..Moreover, dual luciferase reporter system showed that Homeobox A5 was the direct target of miR-130a...
  29. Kenig Kozlovsky Y, Scott R, Onay T, Carota I, Thomson B, Gil H, et al. Ascending Vasa Recta Are Angiopoietin/Tie2-Dependent Lymphatic-Like Vessels. J Am Soc Nephrol. 2018;29:1097-1107 pubmed publisher
    ..medullary AVR exhibited an unusual hybrid endothelial phenotype, expressing lymphatic markers (prospero homeobox protein 1 and vascular endothelial growth factor receptor 3) as well as blood endothelial markers (CD34, ..
  30. Plavicki J, Squirrell J, Eliceiri K, Boekhoff Falk G. Expression of the Drosophila homeobox gene, Distal-less, supports an ancestral role in neural development. Dev Dyn. 2016;245:87-95 pubmed publisher
  31. Zhou D, Wang X, Wang Y, Xiang X, Liang Z, Zhou Y, et al. MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt/?-catenin pathway. Mol Immunol. 2016;75:151-60 pubmed publisher
    ..Mechanistically, we identified that zinc finger E-box-binding homeobox 2 (ZEB2), a key mediator of epithelial-to-mesenchymal transition, acted as a functional downstream target for miR-..
  32. Manabe T, Wanaka A. Regulation and/or Repression of Cholinergic Differentiation of Murine Embryonic Stem Cells Using RNAi Directed Against Transcription Factor L3/Lhx8. Methods Mol Biol. 2017;1622:101-109 pubmed publisher
    ..in murine embryonic stem cells by knockdown of expression of the transcription factor L3/Lhx8, a Lim homeobox gene family protein...
  33. Wu R, Zeng Y, Pan I, Wu M. Androgen Receptor Coactivator ARID4B Is Required for the Function of Sertoli Cells in Spermatogenesis. Mol Endocrinol. 2015;29:1334-46 pubmed publisher
    ..as a "coactivator" of androgen receptor and is required for optimal transcriptional activation of reproductive homeobox 5, an androgen receptor target gene specifically expressed in Sertoli cells and critical for spermatogenesis...
  34. Laxman N, Mallmin H, Nilsson O, Kindmark A. miR-203 and miR-320 Regulate Bone Morphogenetic Protein-2-Induced Osteoblast Differentiation by Targeting Distal-Less Homeobox 5 (Dlx5). Genes (Basel). 2016;8: pubmed publisher
    ..Taken together, we propose a role for miR-203 and miR-320b in modulating bone metabolism. ..
  35. Gu S, Chen K, Yin M, Wu Z, Wu Y. Proteomic profiling of isogenic primary and metastatic medulloblastoma cell lines reveals differential expression of key metastatic factors. J Proteomics. 2017;160:55-63 pubmed publisher
    ..between the primary and metastatic cell lines including known factors such as placental growth factor (PLGF), LIM homeobox 1 (LHX1) and prominim 1 (PROM1), as well as the negative regulator secreted protein acidic and cysteine rich (..
  36. Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, et al. Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells. Oncogene. 2017;36:4963-4974 pubmed publisher
    ..We also characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of GICs...
  37. Chung S, Gillies M, Yam M, Wang Y, Shen W. Differential expression of microRNAs in retinal vasculopathy caused by selective Müller cell disruption. Sci Rep. 2016;6:28993 pubmed publisher
    ..downregulation of miR-200b was negatively correlated with its target genes, including zinc finger E-box binding homeobox (ZEB) 1 and 2 and vascular endothelial growth factor receptor 1...
  38. Occelli L, Tran N, Narfstrom K, Chen S, Petersen Jones S. CrxRdy Cat: A Large Animal Model for CRX-Associated Leber Congenital Amaurosis. Invest Ophthalmol Vis Sci. 2016;57:3780-92 pubmed publisher
    Mutations in the retinal transcription factor cone-rod homeobox (CRX) gene result in severe dominant retinopathies. A large animal model, the Rdy cat, carrying a spontaneous frameshift mutation in Crx, was reported previously...
  39. Kühn M, Song E, Feng Z, Sinha A, Chen C, Deshpande A, et al. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discov. 2016;6:1166-1181 pubmed
    b>Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mutated in acute myeloid leukemia (AML)...
  40. Huang C, Hu Y, Zhao J, Ma X, Zhang Y, Guo F, et al. Long Noncoding RNA HOXC-AS1 Suppresses Ox-LDL-Induced Cholesterol Accumulation Through Promoting HOXC6 Expression in THP-1 Macrophages. DNA Cell Biol. 2016;35:722-729 pubmed
    ..In this study, we found that lncRNA HOXC cluster antisense RNA 1 (HOXC-AS1) and homeobox C6 (HOXC6) were downregulated in carotid atherosclerosis by performing microarray analysis...
  41. Balaji S, Zhou Y, Opara E, Soker S. Combinations of Activin A or Nicotinamide with the Pancreatic Transcription Factor PDX1 Support Differentiation of Human Amnion Epithelial Cells Toward a Pancreatic Lineage. Cell Reprogram. 2017;19:255-262 pubmed publisher
    ..activin A or nicotinamide, alone and in combinations with the transcription factor, PDX1 (pancreatic and duodenal homeobox-1), on human amnion epithelial cells (hAECs) toward a pancreatic lineage...
  42. Chen G, Huang P, Xie J, Li R. microRNA?211 suppresses the growth and metastasis of cervical cancer by directly targeting ZEB1. Mol Med Rep. 2017;: pubmed publisher
    ..Bioinformatics analysis and luciferase reporter assay results indicated that zinc finger E?box binding homeobox 1 (ZEB1) may be a direct target gene of miR?211...
  43. Soret C, Martin E, Duluc I, Dantzer F, Vanier M, Gross I, et al. Distinct mechanisms for opposite functions of homeoproteins Cdx2 and HoxB7 in double-strand break DNA repair in colon cancer cells. Cancer Lett. 2016;374:208-15 pubmed publisher
    b>Homeobox genes, involved in embryonic development and tissues homeostasis in adults, are often deregulated in cancer, but their relevance in pathology is far from being fully elucidated...
  44. Park C, Lee J, Kim M, Shin S, Roh S, Choi J, et al. Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats. Food Funct. 2016;7:3056-63 pubmed publisher
    ..p22(phox), p47(phox), phosphor-c-Jun N-terminal kinase (p-JNK), Bax, cytochrome c, caspase 3, pancreatic-duodenal homeobox (PDX-1) and cyclin E were also performed in the pancreas...
  45. Pan H, Yu H, Ravi V, Li C, Lee A, Lian M, et al. The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate. Gigascience. 2016;5:36 pubmed publisher
    ..genome with that of the pufferfish (fugu), which has a caudal fin, revealed that the sunfish contains more homeobox (Hox) genes although both genomes contain seven Hox clusters...
  46. Chang L, Yuan Y, Li C, Guo T, Qi H, Xiao Y, et al. Upregulation of SNHG6 regulates ZEB1 expression by competitively binding miR-101-3p and interacting with UPF1 in hepatocellular carcinoma. Cancer Lett. 2016;383:183-194 pubmed publisher
    ..effectively becoming a sink for miR-101-3p and thereby modulating the derepression of zinc finger E-box binding homeobox 1, imposing an additional level of post-transcriptional regulation...
  47. He Y, Deng H, Hu Q, Zhu Z, Liu L, Zheng S, et al. Identification of the binding domains and key amino acids for the interaction of the transcription factors BmPOUM2 and BmAbd-A in Bombyx mori. Insect Biochem Mol Biol. 2017;81:41-50 pubmed publisher
    ..BmAbd-A interacted with BmPOUM2 by the homeobox domain or the LCR2 (low complexity region) domain...
  48. Du J, Ba L, Li B, Liu F, Hu X, Zhang J, et al. Distinct expression of NK2 homeobox 1 (NKX2-1) and goblet cell hyperplasia in nasal polyps with different endotypes. Int Forum Allergy Rhinol. 2017;7:690-698 pubmed publisher
    Decreased expression of airway epithelial-specific transcription factor NK2 homeobox 1 (NKX2-1) was associated with allergic inflammation in asthma patients...
  49. Chaudhry A, Chung B, Stavropoulos D, Araya M, Ali A, Heon E, et al. Agenesis of the corpus callosum, developmental delay, autism spectrum disorder, facial dysmorphism, and posterior polymorphous corneal dystrophy associated with ZEB1 gene deletion. Am J Med Genet A. 2017;173:2467-2471 pubmed publisher
    ..23p11.22. The deleted region overlaps 1 OMIM Morbid Map gene, ZEB1 (the zinc finger E-box binding homeobox transcription factor 1), previously associated with posterior polymorphous corneal dystrophy type 3 (PPCD3)...
  50. Feng Q, Snider L, Jagannathan S, Tawil R, van der Maarel S, Tapscott S, et al. A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy. elife. 2015;4: pubmed publisher
    ..DUX4 is a double homeobox transcription factor that is normally expressed in the testis and causes apoptosis and FSHD when misexpressed in ..
  51. Cai J, Xu X, Mou Y, Chen K, Pan Y, Wu D. Upregulation of HOXB7 promotes the tumorigenesis and progression of gastric cancer and correlates with clinical characteristics. Tumour Biol. 2016;37:1641-50 pubmed publisher
    Several examples of aberrant homeobox gene expression have been found across a range of cancers, and it is also confirmed that homeobox genes play a critical roles in tumorigenesis and progression...
  52. Mi Y, Zhao S, Zhou C, Weng J, Li J, Wang Z, et al. Downregulation of homeobox gene Barx2 increases gastric cancer proliferation and metastasis and predicts poor patient outcomes. Oncotarget. 2016;7:60593-60608 pubmed publisher
    ..These findings indicate that reduction or loss of Barx2 dis-inhibits GC cell proliferation and invasion, and that reduction in Barx2 could serve as an independent prognostic biomarker for poor outcome in GC patients. ..
  53. Morin A, Laviolette M, Pastinen T, Boulet L, Laprise C. Combining omics data to identify genes associated with allergic rhinitis. Clin Epigenetics. 2017;9:3 pubmed publisher
    ..We were able to identify one gene with significant cis-mQTL for allergic rhinitis, caudal-type homeobox 1 (CDX1). We also identified 11 genes with marginally significant cis-mQTLs (p?<?0...
  54. Cuesta Astroz Y, Oliveira F, Nahum L, Oliveira G. Helminth secretomes reflect different lifestyles and parasitized hosts. Int J Parasitol. 2017;47:529-544 pubmed publisher
    ..we found five conserved domains: (i) PF00014 (Kunitz/Bovine pancreatic trypsin inhibitor domain), (ii) PF00046 (Homeobox domain), (iii) PF00188 (cysteine-rich secretory proteins, antigen 5, and pathogenesis-related 1 proteins), (iv) ..
  55. Li N, Yang M, Shi K, Li W. Long non-coding RNA HOXA11-AS in human cancer: A meta-analysis. Clin Chim Acta. 2017;474:165-170 pubmed publisher
    b>Homeobox A11 antisense (HOXA11-AS), a newly identified lncRNA, is up-regulated in various carcinomas...
  56. Tanizawa K, Chin K. Genetic factors in sleep-disordered breathing. Respir Investig. 2018;56:111-119 pubmed publisher
    ..hypoventilation syndrome (CCHS) is a genetically inherited disorder caused by mutations in the paired-like homeobox 2B (PHOX2B) gene of polyalanine repeat mutations in the 20-alanine repeat or non-polyalanine repeat mutations...
  57. Shrestha B, Ansari K, Bhan A, Kasiri S, Hussain I, Mandal S. Homeodomain-containing protein HOXB9 regulates expression of growth and angiogenic factors, facilitates tumor growth in vitro and is overexpressed in breast cancer tissue. FEBS J. 2012;279:3715-3726 pubmed publisher
    HOXB9 is a homeobox-containing gene and is critical for the development of mammary gland and sternum. HOXB9 is also regulated by estrogen and is critical for angiogenesis...
  58. Gross S, Balderes D, Liu J, Asfaha S, Gu G, Wang T, et al. Nkx2.2 is expressed in a subset of enteroendocrine cells with expanded lineage potential. Am J Physiol Gastrointest Liver Physiol. 2015;309:G975-87 pubmed publisher
    ..In this study, we demonstrate that the transcription factor NK2 homeobox 2 (Nkx2...
  59. Mahajan A, Kondhare K, Rajabhoj M, Kumar A, Ghate T, Ravindran N, et al. Regulation, overexpression, and target gene identification of Potato Homeobox 15 (POTH15) - a class-I KNOX gene in potato. J Exp Bot. 2016;67:4255-72 pubmed publisher
    Potato Homeobox 15 (POTH15) is a KNOX-I (Knotted1-like homeobox) family gene in potato that is orthologous to Shoot Meristemless (STM) in Arabidopsis...
  60. Takagi M, Kamasaki H, Yagi H, Fukuzawa R, Narumi S, Hasegawa T. A novel heterozygous intronic mutation in POU1F1 is associated with combined pituitary hormone deficiency. Endocr J. 2017;64:229-234 pubmed publisher
    POU class 1 homeobox 1 (POU1F1) regulates pituitary cell-specific gene expression of somatotropes, lactotropes, and thyrotropes...
  61. Singh D, Kollipara R, Vemireddy V, Yang X, Sun Y, Regmi N, et al. Oncogenes Activate an Autonomous Transcriptional Regulatory Circuit That Drives Glioblastoma. Cell Rep. 2017;18:961-976 pubmed publisher
    ..We identified oligodendrocyte lineage transcription factor 2 (OLIG2) and zinc-finger E-box binding homeobox 1 (ZEB1), which are frequently co-expressed irrespective of driver mutations, as potential SOX2 targets...
  62. Douglas S, Li B, Kliebenstein D, Nambara E, Riggs C. A novel Filamentous Flower mutant suppresses brevipedicellus developmental defects and modulates glucosinolate and auxin levels. PLoS ONE. 2017;12:e0177045 pubmed publisher
    BREVIPEDICELLUS (BP) encodes a class-I KNOTTED1-like homeobox (KNOX) transcription factor that plays a critical role in conditioning a replication competent state in the apical meristem, and it also governs growth and cellular ..
  63. Campione M, Franco D. Current Perspectives in Cardiac Laterality. J Cardiovasc Dev Dis. 2016;3: pubmed publisher
    ..network, which invariably converges on the Tgf-? signaling molecule Nodal and its downstream target, the homeobox transcription factor Pitx2...
  64. Liang H, Zhang Q, Lu J, Yang G, Tian N, Wang X, et al. MSX2 Induces Trophoblast Invasion in Human Placenta. PLoS ONE. 2016;11:e0153656 pubmed publisher
    ..Msh Homeobox 2 (MSX2), a member of the MSX family of homeobox proteins, plays a significant role in the proliferation and ..
  65. Ding W, Zhou M, Chen M, Qu C. HOXB8 promotes tumor metastasis and the epithelial-mesenchymal transition via ZEB2 targets in gastric cancer. J Cancer Res Clin Oncol. 2017;143:385-397 pubmed publisher
    The homeobox B8 (HOXB8) functions as a sequence-specific transcription factor that is involved in development...
  66. Dunwell T, Holland P. Diversity of human and mouse homeobox gene expression in development and adult tissues. BMC Dev Biol. 2016;16:40 pubmed
    b>Homeobox genes encode a diverse set of transcription factors implicated in a vast range of biological processes including, but not limited to, embryonic cell fate specification and patterning...
  67. Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, et al. Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1. Proc Natl Acad Sci U S A. 2017;114:E1234-E1242 pubmed publisher
    ..Studies performed in murine models have identified some transcriptional determinants, including GS Homeobox 2 (Gsx2) and Early B-cell factor 1 (Ebf1)...
  68. Kristiansen I, Stephan C, Jung K, Dietel M, Rieger A, Tolkach Y, et al. Sensitivity of HOXB13 as a Diagnostic Immunohistochemical Marker of Prostatic Origin in Prostate Cancer Metastases: Comparison to PSA, Prostein, Androgen Receptor, ERG, NKX3.1, PSAP, and PSMA. Int J Mol Sci. 2017;18: pubmed publisher
    ..Recently, homeobox protein Hox-B13 (HOXB13) has been suggested as a new marker for the detection of prostatic origin...
  69. Hao Q, He L, Zhou J, Yuan Y, Ma X, Pang Z, et al. A dimeric thymosin beta 4 with novel bio-activity protects post-ischemic cardiac function by accelerating vascular endothelial cell proliferation. Int J Cardiol. 2018;261:146-154 pubmed publisher
    ..assay demonstrated that DT?4 enhanced MALAT1 transcription by inhibiting the degradation of prospero-related homeobox 1 (PROX1). This study demonstrates the potential applications and the novel bioactivity of the T?4 dimer...
  70. Jernman J, Kallio P, Hagström J, Välimäki M, Haapasalo H, Alitalo K, et al. PROX1 is involved in progression of rectal neuroendocrine tumors, NETs. Virchows Arch. 2015;467:279-84 pubmed publisher
    PROX1 is a homeobox transcription factor involved in the development of the lens, liver and heart and found upregulated in colorectal cancers. We studied PROX1 expression by immunohistochemistry in rectal neuroendocrine tumors (NETs)...
  71. Zeng Z, Yu R, Zuo F, Zhang B, Peng D, Ma H, et al. Heterologous Expression and Delivery of Biologically Active Exendin-4 by Lactobacillus paracasei L14. PLoS ONE. 2016;11:e0165130 pubmed publisher
    ..The transcription level of the pancreatic duodenal homeobox-1 gene (PDX-1), a key transcription factor for cellular insulin synthesis and secretion, was upregulated by the ..
  72. Wang D, Qin J, Jia J, Yan P, Li W. Pou1f1, the key transcription factor related to somatic growth in tilapia (Orechromis niloticus), is regulated by two independent post-transcriptional regulation mechanisms. Biochem Biophys Res Commun. 2017;483:559-565 pubmed publisher
    ..aims to determine the post-transcriptional regulation mechanism of the transcription factor pou1f1 (pou class 1 homeobox 1), which is the key gene for pituitary development, somatic growth in vertebrates, and transcription of several ..
  73. Mihara Y, Matsuura K, Sakamoto Y, Okano T, Kokudo N, Shimizu T. Production of pancreatic progenitor cells from human induced pluripotent stem cells using a three-dimensional suspension bioreactor system. J Tissue Eng Regen Med. 2017;11:3193-3201 pubmed publisher
    ..About 95% of cells expressed pancreatic and duodenal homeobox factor 1, and 22% co-expressed the transcription factor NKX6.1...
  74. An Z, Liu Y, Song Z, Tang H, Yuan Y, Xu Z. Mechanisms of aortic dissection smooth muscle cell phenotype switch. J Thorac Cardiovasc Surg. 2017;154:1511-1521.e6 pubmed publisher
    To investigate the expression of Nanog homeobox (NANOG) in thoracic aortic dissection (TAD) and the role of NANOG in regulating human aortic vascular smooth muscle cells (VSMCs) phenotype switch...
  75. Long Z, Bai Z, Song J, Zheng Z, Li J, Zhang J, et al. miR-141 Inhibits Proliferation and Migration of Colorectal Cancer SW480 Cells. Anticancer Res. 2017;37:4345-4352 pubmed
    ..miR-141 directly targeted zinc finger E-box-binding homeobox 1/2 (ZEB1/2)...
  76. Armour S, Remsberg J, Damle M, Sidoli S, Ho W, Li Z, et al. An HDAC3-PROX1 corepressor module acts on HNF4? to control hepatic triglycerides. Nat Commun. 2017;8:549 pubmed publisher
    ..HDAC3 interactome in vivo that includes the canonical NCoR-HDAC3 complex as well as Prospero-related homeobox 1 protein (PROX1)...
  77. Holland P, Marlétaz F, Maeso I, Dunwell T, Paps J. New genes from old: asymmetric divergence of gene duplicates and the evolution of development. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed
    ..We describe examples of asymmetric evolution in duplicated homeobox genes of moths, molluscs and mammals, in each case generating new homeobox genes that were recruited to novel ..
  78. Yang J, Tian B, Sun H, Garofalo R, Brasier A. Epigenetic silencing of IRF1 dysregulates type III interferon responses to respiratory virus infection in epithelial to mesenchymal transition. Nat Microbiol. 2017;2:17086 pubmed publisher
    ..Induced by the EMT, zinc finger E-box binding homeobox 1 (ZEB1) binds and silences IRF1...
  79. Pan C, Gao H, Zheng N, Gao Q, Si Y, Zhao Y. MiR-320 inhibits the growth of glioma cells through downregulating PBX3. Biol Res. 2017;50:31 pubmed publisher
    ..PBX3 (Pre-B cell leukemia homeobox 3), a putative target gene of miR-320, has been reported to be upregulated in various tumors and promote tumor ..
  80. Chen C, Yan Q, Liu K, Zhou X, Xian Y, Liang D, et al. Endometrial Receptivity Markers in Mice Stimulated With Raloxifene Versus Clomiphene Citrate and Natural Cycles. Reprod Sci. 2016;23:748-55 pubmed publisher
    ..This study aimed to compare the expression of endometrial receptivity markers, including homeobox gene 10 (HOXA10), integrin β3, and leukemia inhibitory factor (LIF), as well as pinopode production during the ..
  81. Busada J, Velte E, Serra N, Cook K, Niedenberger B, Willis W, et al. Rhox13 is required for a quantitatively normal first wave of spermatogenesis in mice. Reproduction. 2016;152:379-88 pubmed publisher
    We previously described a novel germ cell-specific X-linked reproductive homeobox gene (Rhox13) that is upregulated at the level of translation in response to retinoic acid (RA) in differentiating spermatogonia and preleptotene ..
  82. Ju H, Lee S, Lee J, Ghil S. Necdin modulates osteogenic cell differentiation by regulating Dlx5 and MAGE-D1. Biochem Biophys Res Commun. 2017;489:109-115 pubmed publisher
    ..osteogenic cell line through formation of a complex with melanoma-associated antigen D1 (MAGE-D1) and distal-less Homeobox 5 (Dlx5) and Runx2 promoter activation...
  83. Saxena P, Bojar D, Zulewski H, Fussenegger M. Generation of glucose-sensitive insulin-secreting beta-like cells from human embryonic stem cells by incorporating a synthetic lineage-control network. J Biotechnol. 2017;259:39-45 pubmed publisher
    ..dynamics of the key transcription factors Ngn3 (neurogenin 3, OFF-ON-OFF), Pdx1 (pancreatic and duodenal homeobox 1, ON-OFF-ON) and MafA (V-maf musculoaponeurotic fibrosarcoma oncogene homologue A, OFF-ON) to guide the ..
  84. Swope D, Kramer J, King T, Cheng Y, Kramer S. Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure. Dev Biol. 2014;392:221-32 pubmed publisher
    ..Disruption of Cdc42 function specifically prevents CBs that express the homeobox gene tinman from completing their dorsal migration, resulting in a failure to make connections with their ..
  85. Weiss E, Hanzelmann D, Fehlhaber B, Klos A, von Loewenich F, Liese J, et al. Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections. FASEB J. 2018;32:26-36 pubmed publisher
    ..We characterized the specificity of mouse FPR2 (mFpr2) using a receptor-transfected cell line, homeobox b8 (Hoxb8), and primary neutrophils isolated from wild-type (WT) or mFpr2-/- mice...
  86. Xu X, Cai N, Bao Z, You Y, Ji J, Liu N. Silencing Pre-B-cell leukemia homeobox 3 decreases the proliferation of human glioma cells in vitro and in vivo. J Neurooncol. 2017;135:453-463 pubmed publisher
    ..Pre-B-cell leukemia homeobox 3 (PBX3), a critical member of the PBX family, is frequently overexpressed in multiple human malignancies...
  87. Socorro M, Criscimanna A, Riva P, Tandon M, Prasadan K, Guo P, et al. Identification of Newly Committed Pancreatic Cells in the Adult Mouse Pancreas. Sci Rep. 2017;7:17539 pubmed publisher
    ..cells residing in the adult mouse pancreas have the ability to initiate Pancreatic and duodenal homeobox (Pdx1) expression for the first time...
  88. Li X, Xu G, Zhai Z, Gao C, Yan H, Xi Q, et al. CDX2 increases SLC7A7 expression and proliferation of pig intestinal epithelial cells. Oncotarget. 2016;7:30597-609 pubmed publisher
    ..We evaluated the role of Caudal type homeobox 2 (CDX2), an intestine-specific transcription factor, in the proliferation of pig intestinal epithelial cells (..
  89. Smith A, Rohrer B, Wheless L, Samantaray S, Ray S, Inoue J, et al. Calpain inhibition reduces structural and functional impairment of retinal ganglion cells in experimental optic neuritis. J Neurochem. 2016;139:270-284 pubmed publisher
    ..calpain inhibitor SNJ 1945 preserves visual acuity and preserves retinal ganglion cells (Brn3a, brain-specific homeobox/POU domain protein 3A) and their axons (MOSP, myelin oligodendrocyte-specific protein)...
  90. Wang X, Chen S, Burtscher I, Sterr M, Hieronimus A, Machicao F, et al. Generation of a human induced pluripotent stem cell (iPSC) line from a patient with family history of diabetes carrying a C18R mutation in the PDX1 gene. Stem Cell Res. 2016;17:292-295 pubmed publisher
    Homozygous loss-of-function mutations in the gene coding for the homeobox transcription factor PDX1 leads to pancreatic agenesis, whereas certain heterozygous point mutations are associated with Maturity-Onset Diabetes of the Young 4 (..
  91. Li H, Li J, Yang T, Lin S, Li H. MicroRNA-433 Represses Proliferation and Invasion of Colon Cancer Cells by Targeting Homeobox A1. Oncol Res. 2017;: pubmed publisher
    ..b>Homeobox A1 (HOXA1) was identified as a target of miR-433 and it mediated the functions of miR-433 on colon cancer cell...
  92. Brantley J, Sharma M, Alcalay N, Heuvel G. Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis. Kidney Int. 2003;63:1240-8 pubmed
    Cux-1 is a murine homeobox gene that is highly expressed in the nephrogenic zone of the developing kidney...