HNF4A

Summary

Gene Symbol: HNF4A
Description: hepatocyte nuclear factor 4, alpha
Alias: HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14, HNF4alpha10/11/12, TCF-14, hepatic nuclear factor 4 alpha, hepatocyte nuclear factor 4-alpha, nuclear receptor subfamily 2 group A member 1, transcription factor 14, transcription factor HNF-4
Species: human

Top Publications

  1. ncbi Mutations in the hepatocyte nuclear factor-4alpha gene in Japanese with non-insulin-dependent diabetes: a nucleotide substitution in the polypyrimidine tract of intron 1b
    K Sakurai
    Department of Internal Medicine II, Chiba University School of Medicine, Japan
    Horm Metab Res 32:316-20. 2000
  2. pmc Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity
    Hongtao Guo
    Department of Surgery, Duke University Medical Center, Durham, NC 27514, USA
    Biochem J 394:379-87. 2006
  3. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:1645-8. 2002
  4. pmc Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis
    Yuxia Zhang
    Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 286:29635-43. 2011
  5. ncbi Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription
    Frank J Gonzalez
    Laboratory of Metabolism, National Cancer Institute, National Instituted of Health, Bethesda, Maryland 20892, USA
    Drug Metab Pharmacokinet 23:2-7. 2008
  6. pmc Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells
    Valérie Marcil
    Research Institute, McGill University, Campus MGH, C10 148 6, Montreal H3G 1A4, Quebec
    J Biol Chem 285:40448-60. 2010
  7. ncbi Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus
    JianPing Weng
    Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    Diabetes Care 25:68-71. 2002
  8. ncbi HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma
    Belén Lucas
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, D 45122 Essen, Germany
    Oncogene 24:6418-31. 2005
  9. pmc The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes
    Hugues de Boussac
    Institute of Enzymology, Hungarian Academy of Sciences, Karolina ut 29, 1113 Budapest, Hungary
    J Biol Chem 285:22800-8. 2010
  10. doi Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations
    Ritika R Kapoor
    London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, and the Institute of Child Health, University College London, London, UK
    Diabetes 57:1659-63. 2008

Research Grants

Detail Information

Publications200 found, 100 shown here

  1. ncbi Mutations in the hepatocyte nuclear factor-4alpha gene in Japanese with non-insulin-dependent diabetes: a nucleotide substitution in the polypyrimidine tract of intron 1b
    K Sakurai
    Department of Internal Medicine II, Chiba University School of Medicine, Japan
    Horm Metab Res 32:316-20. 2000
    Mutations of the hepatocyte nuclear factor 4 alpha (HNF-4alpha) gene have been demonstrated in maturity-onset diabetes of the young (MODY) 1 families...
  2. pmc Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity
    Hongtao Guo
    Department of Surgery, Duke University Medical Center, Durham, NC 27514, USA
    Biochem J 394:379-87. 2006
    ..The corresponding transcription factor was identified to be HNF4alpha (hepatocyte nuclear factor-4alpha)...
  3. ncbi Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor
    Jiandie Lin
    Dana Farber Cancer Institute and the Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:1645-8. 2002
    ..HCF is shown to bind to both PGC-1alpha and -1beta and augment their transcriptional activity...
  4. pmc Diurnal regulation of the early growth response 1 (Egr-1) protein expression by hepatocyte nuclear factor 4alpha (HNF4alpha) and small heterodimer partner (SHP) cross-talk in liver fibrosis
    Yuxia Zhang
    Department of Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    J Biol Chem 286:29635-43. 2011
    ..Hepatocyte nuclear factor 4α (HNF4α) activated the Egr-1 promoter through three DR1 response elements as identified by trans-activation assays...
  5. ncbi Regulation of hepatocyte nuclear factor 4 alpha-mediated transcription
    Frank J Gonzalez
    Laboratory of Metabolism, National Cancer Institute, National Instituted of Health, Bethesda, Maryland 20892, USA
    Drug Metab Pharmacokinet 23:2-7. 2008
    Hepatocyte nuclear factor 4alpha (HNF4alpha, NR2A1) is required for development of the liver and for controlling the expression of many genes specifically expressed in the liver and associated with a number of critical metabolic pathways...
  6. pmc Modification in oxidative stress, inflammation, and lipoprotein assembly in response to hepatocyte nuclear factor 4alpha knockdown in intestinal epithelial cells
    Valérie Marcil
    Research Institute, McGill University, Campus MGH, C10 148 6, Montreal H3G 1A4, Quebec
    J Biol Chem 285:40448-60. 2010
    ..To this end, the HNF4A gene was knocked down by transfecting Caco-2 cells with a pGFP-V-RS lentiviral vector containing an shRNA against ..
  7. ncbi Screening for MODY mutations, GAD antibodies, and type 1 diabetes--associated HLA genotypes in women with gestational diabetes mellitus
    JianPing Weng
    Department of Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    Diabetes Care 25:68-71. 2002
    To investigate whether genetic susceptibility to type 1 diabetes or maturity-onset diabetes of the young (MODY) increases susceptibility to gestational diabetes mellitus (GDM).
  8. ncbi HNF4alpha reduces proliferation of kidney cells and affects genes deregulated in renal cell carcinoma
    Belén Lucas
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, D 45122 Essen, Germany
    Oncogene 24:6418-31. 2005
    Hepatocyte nuclear factor 4alpha (HNF4alpha) is a tissue-specific transcription factor known to regulate a large number of genes in hepatocytes and pancreatic beta cells...
  9. pmc The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes
    Hugues de Boussac
    Institute of Enzymology, Hungarian Academy of Sciences, Karolina ut 29, 1113 Budapest, Hungary
    J Biol Chem 285:22800-8. 2010
    ..the tissue-specific expression pattern to the gene and with a putative hepatocyte nuclear factor 4alpha (HNF4alpha) binding site...
  10. doi Persistent hyperinsulinemic hypoglycemia and maturity-onset diabetes of the young due to heterozygous HNF4A mutations
    Ritika R Kapoor
    London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, and the Institute of Child Health, University College London, London, UK
    Diabetes 57:1659-63. 2008
    Mutations in the human HNF4A gene encoding the hepatocyte nuclear factor (HNF)-4alpha are known to cause maturity-onset diabetes of the young (MODY), which is characterized by autosomal-dominant inheritance and impaired glucose-..
  11. ncbi SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4
    J C Wang
    Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, Tennessee 37232 0615, USA
    J Biol Chem 273:30847-50. 1998
    ..Type 1 maturity onset diabetes of young (MODY), which is characterized by abnormal glucose-mediated insulin secretion, is caused by mutations of the HNF4 gene...
  12. pmc Hepatocyte nuclear factor 4alpha contributes to thyroid hormone homeostasis by cooperatively regulating the type 1 iodothyronine deiodinase gene with GATA4 and Kruppel-like transcription factor 9
    Hiroto Ohguchi
    Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    Mol Cell Biol 28:3917-31. 2008
    ..Dio1 mRNA and enzyme activity levels are markedly reduced in the livers of hepatocyte nuclear factor 4alpha (HNF4alpha)-null mice, thus accounting for its liver-specific expression...
  13. pmc Diazoxide-responsive hyperinsulinemic hypoglycemia caused by HNF4A gene mutations
    S E Flanagan
    Peninsula Medical School, Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK
    Eur J Endocrinol 162:987-92. 2010
    The phenotype associated with heterozygous HNF4A gene mutations has recently been extended to include diazoxide responsive neonatal hypoglycemia in addition to maturity-onset diabetes of the young (MODY)...
  14. ncbi CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression
    H Dell
    Department of Medicine, Section of Molecular Genetics, Cardiovascular Institute, Boston University School of Medicine, Center for Advanced Biomedical Research, Boston, Massachusetts 02118 2394, USA
    J Biol Chem 274:9013-21. 1999
    ..These findings demonstrate that CBP acts as a transcriptional coactivator for HNF-4 and provide new insights into the regulatory function of HNF-4...
  15. ncbi Apolipoprotein A-IV is regulated by nutritional and metabolic stress: involvement of glucocorticoids, HNF-4 alpha, and PGC-1 alpha
    Elyhisha A Hanniman
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Lipid Res 47:2503-14. 2006
    ..Together, these results indicate that the induction of apoA-IV expression in fasting and diabetes likely involves PGC-1 alpha-mediated coactivation of HNF-4 alpha in addition to glucocorticoid-dependent actions...
  16. ncbi Hepatocyte nuclear factor-4{alpha} regulates the human organic anion transporter 1 gene in the kidney
    Ken Ogasawara
    Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Kyoto University, Kyoto, Japan
    Am J Physiol Renal Physiol 292:F1819-26. 2007
    ..This paper reports the first characterization of the human OAT1 promoter and the first gene in the kidney whose promoter activity is regulated by HNF-4alpha...
  17. ncbi Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha
    S Pruhova
    Department of Paediatrics, 3rd Faculty of Medicine, Charles University, Vinohradska 159, 100 81 Prague 10, Czech Republic
    Diabetologia 46:291-5. 2003
    The aim of this study was to examine the prevalence and nature of mutations in HNF4alpha/MODY1, GCK/MODY2 and HNF-1alpha/MODY3 genes in Czech subjects with clinical diagnosis of MODY.
  18. pmc Involvement of corepressor complex subunit GPS2 in transcriptional pathways governing human bile acid biosynthesis
    Sabyasachi Sanyal
    Department of Biosciences and Nutrition, Karolinska Institutet, Karolinska University Hospital, S 14157 Huddinge, Sweden
    Proc Natl Acad Sci U S A 104:15665-70. 2007
    ..receptors including the orphan receptors liver receptor homolog 1 (LRH-1), hepatocyte nuclear factor 4alpha (HNF4alpha), small heterodimer partner (SHP), and the bile acid receptor FXR (farnesoid X receptor)...
  19. pmc Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors
    G Jiang
    Environmental Toxicology Graduate Program, University of California, Riverside 92521, USA
    Mol Cell Biol 15:5131-43. 1995
    ..These findings lead us to propose that HNF-4 defines a new subclass of nuclear receptors which reside primarily in the nucleus and which bind DNA and regulate transcription as homodimers...
  20. pmc Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8
    Koichi Sumi
    Laboratory of Systems Biology and Medicine, Research Center for Advanced Science and Technology, University of Tokyo, 4 6 1 Komaba, Meguro, Tokyo, Japan
    Mol Cell Biol 27:4248-60. 2007
    ..Here, we identified a binding site for hepatocyte nuclear factor 4alpha (HNF4alpha) in the ABCG5/ABCG8 intergenic promoter, through which HNF4alpha strongly activated the expression of a reporter ..
  21. pmc Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation
    Dipanjan Chanda
    Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea
    Nucleic Acids Res 38:4607-19. 2010
    ....
  22. pmc Structural basis of natural promoter recognition by a unique nuclear receptor, HNF4alpha. Diabetes gene product
    Peng Lu
    Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky 40536, USA
    J Biol Chem 283:33685-97. 2008
    b>HNF4alpha (hepatocyte nuclear factor 4alpha) plays an essential role in the development and function of vertebrate organs, including hepatocytes and pancreatic beta-cells by regulating expression of multiple genes involved in organ ..
  23. pmc Mechanism of a transcriptional cross talk between transforming growth factor-beta-regulated Smad3 and Smad4 proteins and orphan nuclear receptor hepatocyte nuclear factor-4
    Wan Chih Chou
    Department of Basic Sciences, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, Foundation of Research and Technology of Hellas, Heraklion GR 71110, Greece
    Mol Biol Cell 14:1279-94. 2003
    ..Furthermore, the specificity of this interaction for certain target promoters may play an important role in various hepatocyte functions, which are regulated by TGFbeta and the Smads...
  24. ncbi Mitogen-activated protein kinase regulates transcription of the ApoCIII gene. Involvement of the orphan nuclear receptor HNF4
    S Reddy
    Department of Cell Biology, Parke Davis Research, Ann Arbor, Michigan 48105, USA
    J Biol Chem 274:33050-6. 1999
    ..The major protein binding to this site was identified as the nuclear hormone receptor HNF4. An increase in HNF4 mRNA and protein levels was observed in HepG2 cells after treatment with PD98059, indicating ..
  25. pmc A beta-catenin/TCF-coordinated chromatin loop at MYC integrates 5' and 3' Wnt responsive enhancers
    Gregory S Yochum
    Vollum Institute and Division of Hematology and Medical Oncology, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 107:145-50. 2010
    ..Each enhancer directly binds members of the TCF/Lef family of transcription factors that, in turn, recruit beta-catenin...
  26. ncbi AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability
    Yu Holly Hong
    Department of Pathology and the Center for Integrative Metabolic and Endocrine Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Biol Chem 278:27495-501. 2003
    ..The transcription factor hepatic nuclear factor 4alpha (HNF4alpha) is an orphan nuclear receptor that regulates the expression of genes involved in energy metabolism in the liver,..
  27. doi Can complement factors 5 and 8 and transthyretin be used as biomarkers for MODY 1 (HNF4A-MODY) and MODY 3 (HNF1A-MODY)?
    E Karlsson
    Department of Clinical Sciences Diabetes and Endocrinology, Malmo University Hospital, Lund University, Malmo, Sweden
    Diabet Med 25:788-91. 2008
    ..We therefore set out to determine whether serum concentrations of C5, C8 and TTR can be used as biomarkers for patients with HNF4A-MODY and HNF1A-MODY.
  28. pmc Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1
    J L Bento
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Genomics 92:226-34. 2008
    ..The most significant SNPs were found in the perigenic regions: HNF4A (hepatocyte nuclear factor 4alpha), SLC12A5 (potassium-chloride cotransporter member 5), CDH22 (cadherin-like 22), ..
  29. ncbi Polyamines modulate the interaction between nuclear receptors and vitamin D receptor-interacting protein 205
    Yutaka Maeda
    Environmental Toxicology Graduate Program, University of California, Riverside, California 92521, USA
    Mol Endocrinol 16:1502-10. 2002
    ..remains a mystery, as does the mechanism by which orphan receptors such as hepatocyte nuclear factor 4alpha (HNF4alpha) activate transcription...
  30. pmc Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo
    Serkan Kir
    Department of Pharmacology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 287:41334-41. 2012
    ..Here, in a series of loss-of-function studies, we show that the nuclear receptors HNF4α and LRH-1 have dual roles in regulating Cyp7a1 in vivo...
  31. pmc Mapping of HNF4alpha target genes in intestinal epithelial cells
    Mette Boyd
    Department of Cellular and Molecular Medicine, Panum Institute, Building 6, 4, University of Copenhagen, Blegdamsvej 3B 2200 Copenhagen N, Denmark
    BMC Gastroenterol 9:68. 2009
    The role of HNF4alpha has been extensively studied in hepatocytes and pancreatic beta-cells, and HNF4alpha is also regarded as a key regulator of intestinal epithelial cell differentiation...
  32. pmc NR2F1 disrupts synergistic activation of the MTTP gene transcription by HNF-4α and HNF-1α
    Kezhi Dai
    Departments of Cell Biology and Pediatrics, Program of Molecular and Cellular Biology, School of Graduate Studies, SUNY Downstate Medical Center, Brooklyn, NY, USA
    J Lipid Res 53:901-8. 2012
    ..In this mechanism, NR2F1 does not affect activities of individual transcription factors; instead, it abrogates synergistic activation by HNF-4α and HNF-1 proteins...
  33. pmc Disease progression and search for monogenic diabetes among children with new onset type 1 diabetes negative for ICA, GAD- and IA-2 Antibodies
    Sven Pörksen
    Department of Pediatrics, Glostrup Hospital and University of Copenhagen, Copenhagen, Denmark
    BMC Endocr Disord 10:16. 2010
    ..Furthermore the study aimed at determining whether mutations in KCNJ11, ABCC8, HNF1A, HNF4A or INS are common in AAB negative diabetes.
  34. doi Hepatocyte nuclear factor-4alpha and bile acids regulate human concentrative nucleoside transporter-1 gene expression
    Kerstin Klein
    Division of Clinical Pharmacology and Toxicology, Department of Internal Medicine, University Hospital, Ramistrasse 100, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 296:G936-47. 2009
    ..Supporting the physiological relevance and species conservation of this effect, ileal Cnt1 mRNA expression was decreased upon bile acid feeding and increased upon bile duct ligation in mice...
  35. pmc Proteomic analysis of native hepatocyte nuclear factor-4α (HNF4α) isoforms, phosphorylation status, and interactive cofactors
    Kenji Daigo
    Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    J Biol Chem 286:674-86. 2011
    Hepatocyte nuclear factor-4α (HNF4α, NR2A1) is a nuclear receptor that has a critical role in hepatocyte differentiation and the maintenance of homeostasis in the adult liver...
  36. ncbi SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4
    D Kardassis
    Department of Basic Sciences, University of Crete Medical School and Institute of Molecular Biology and Biotechnology, F O R T H, Heraklion GR 71110, Crete, Greece
    J Biol Chem 275:41405-14. 2000
    ....
  37. pmc Effects of hepatocyte nuclear factor-4alpha on the regulation of the hepatic acute phase response
    Zhongyan Wang
    Department of Surgery, Boston University School of Medicine, Boston, MA 02118, USA
    J Mol Biol 371:323-35. 2007
    ....
  38. doi Protein expression of nuclear receptors in human and murine tissues
    So Takegoshi
    Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Pathol Int 59:61-72. 2009
    ..The P2 promoter-driven hepatocyte nuclear factor 4alpha (HNF4alpha) isoform and progesterone receptor were expressed in pancreatic alpha-cells, but not beta-cells in the human ..
  39. ncbi Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers
    Takeshi Ozeki
    Laboratory of Drug Metabolism, Division of Pharmacobio dynamics, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    Pharmacogenetics 13:49-53. 2003
    ..These results suggest that the expression level of DD4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha, HNF-4 alpha and HNF-4 gamma...
  40. doi The diabetic phenotype in HNF4A mutation carriers is moderated by the expression of HNF4A isoforms from the P1 promoter during fetal development
    Lorna W Harries
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Exeter, UK
    Diabetes 57:1745-52. 2008
    Mutations in the alternatively spliced HNF4A gene cause maturity-onset diabetes of the young (MODY)...
  41. pmc The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression
    Y K Lee
    Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Mol Cell Biol 20:187-95. 2000
    ..Overall, these results suggest that SHP represses nuclear hormone receptor-mediated transactivation via two separate steps: first by competition with coactivators and then by direct effects of its transcriptional repressor function...
  42. ncbi HNF-4alpha: from MODY to late-onset type 2 diabetes
    Rana K Gupta
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Trends Mol Med 10:521-4. 2004
    Maturity-onset diabetes of the young (MODY) is a rare subtype of type 2 diabetes that is characterized by autosomal-dominant inheritance and can be caused by mutations in hepatocyte nuclear factor 4alpha (HNF-4alpha)...
  43. ncbi Nuclear receptor binding factor-1 (NRBF-1), a protein interacting with a wide spectrum of nuclear hormone receptors
    N Masuda
    Department of Life Science, Himeji Institute of Technology, Kamigori, Hyogo 678 1297, Japan
    Gene 221:225-33. 1998
    ..NRBF-1 has a significant homology to the yeast protein MRF1, a putative transcription factor regulating the expression of mitochondrial respiratory proteins. NRBF-1 might be another type of nuclear receptor co-operator...
  44. pmc Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential
    E Ktistaki
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Herakleion Crete, Greece
    Proc Natl Acad Sci U S A 92:9876-80. 1995
    ..The correlation between the intranuclear distribution of HNF-4 and its ability to activate endogenous target genes demonstrates a phosphorylation signal-dependent pathway in the regulation of transcription factor activity...
  45. pmc Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action
    Ines Barroso
    Incyte, Palo Alto, California, USA
    PLoS Biol 1:E20. 2003
    ..2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)-significantly altered disease risk, and in three genes, the risk allele, haplotype, or both ..
  46. ncbi SREBP-1 interacts with hepatocyte nuclear factor-4 alpha and interferes with PGC-1 recruitment to suppress hepatic gluconeogenic genes
    Takashi Yamamoto
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    J Biol Chem 279:12027-35. 2004
    ..Our data indicate that SREBP-1 has a novel role as negative regulator of gluconeogenic genes through a cross-talk with HNF-4alpha interference with PGC-1 recruitment...
  47. ncbi Nitric oxide and TGF-beta1 inhibit HNF-4alpha function in HEPG2 cells
    Susana de Lucas Sd
    Fundacion para el Estudio de las Hepatitis Virales, Madrid, Spain
    Biochem Biophys Res Commun 321:688-94. 2004
    ..TGF-beta1 and nitric oxide inhibit HNF-4alpha activity. These findings may explain the loss of liver functions that occurs during fibrosis progression...
  48. ncbi Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4alpha isoforms
    Jean Marc Pascussi
    INSERM, U632, Montpellier, France
    Hepatology 45:1146-53. 2007
    ..hepatocytes, electromobility shift and cotransfection assays, we identified a functional and species-conserved HNF4alpha response element (DR1: ccAGGCCTtTGCCCTga) at nucleotide -144...
  49. doi HNF4 alpha orchestrates a set of 14 genes to down-regulate cell proliferation in kidney cells
    Karen Grigo
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, D 45122 Essen, Germany
    Biol Chem 389:179-87. 2008
    ..The cell-specific transcription factor hepatocyte nuclear factor 4 alpha (HNF4 alpha) is down-regulated in RCC and we have shown that HNF4 alpha inhibits cell proliferation ..
  50. pmc beta-Catenin/TCF/LEF regulate expression of the short form human Cripto-1
    Shin Hamada
    Mammary Biology and Tumorigenesis Laboratory, NCI CCR, 37 Convent Drive, Building 37, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 355:240-4. 2007
    ..of human colorectal tumors and hepatomas are known to possess a constitutively active canonical Wnt/beta-catenin/TCF signaling pathway, also express CR-1...
  51. pmc FoxO1 and HNF-4 are involved in regulation of hepatic glucokinase gene expression by resveratrol
    Goutham Kumar Ganjam
    Faculty of Chemistry, Department of Biochemistry, University of Kaiserslautern, D 67663 Kaiserslautern, Germany
    J Biol Chem 284:30783-97. 2009
    ..These results provide the first evidence that resveratrol represses GK expression via FoxO1 and that the interaction between FoxO1 and HNF-4 contributes to these effects of resveratrol...
  52. doi Regulation of vascular endothelial growth factor D by orphan receptors hepatocyte nuclear factor-4 alpha and chicken ovalbumin upstream promoter transcription factors 1 and 2
    Georgia Schäfer
    Laboratory for Angiogenesis and Tumor Metastasis, Charite University Hospital, Berlin, Germany
    Cancer Res 68:457-66. 2008
    ..The vegf-D DR element is bound and activated by the orphan receptors hepatocyte nuclear factor 4 alpha (HNF-4 alpha) and chicken ovalbumin upstream promoter transcription factor (COUP-TF)-1/COUP-TF2...
  53. pmc Mitogen-activated protein kinase-mediated disruption of enhancer-promoter communication inhibits hepatocyte nuclear factor 4alpha expression
    Pantelis Hatzis
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece
    Mol Cell Biol 26:7017-29. 2006
    ....
  54. pmc TRAP/SMCC/mediator-dependent transcriptional activation from DNA and chromatin templates by orphan nuclear receptor hepatocyte nuclear factor 4
    Sohail Malik
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, NY 10021, USA
    Mol Cell Biol 22:5626-37. 2002
    ..Finally, recruitment experiments using immobilized templates strongly suggest that the functional consequences of the physical interaction probably are manifested at a postrecruitment step in the activation pathway...
  55. ncbi Isolation and characterization of a third isoform of human hepatocyte nuclear factor 4
    A A Kritis
    Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Herakleion, Crete, Greece
    Gene 173:275-80. 1996
    ....
  56. ncbi Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha
    Olivier Barbier
    Unité INSERM 545, Institut Pasteur de Lille, 1 rue du Pr Calmette, BP 245, 59019 Lille, France
    Mol Pharmacol 67:241-9. 2005
    ..Liver-specific disruption of the HNF4alpha gene in mice drastically decreases liver UGT1A9 mRNA levels...
  57. ncbi P2 promoter variants of the hepatocyte nuclear factor 4alpha gene are associated with type 2 diabetes in Mexican Americans
    Donna M Lehman
    Department of Medicine Clinical Epidemiology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Diabetes 56:513-7. 2007
    Common and rare variants of the hepatocyte nuclear factor 4alpha (HNF4A) gene have been associated with type 2 diabetes and related traits in several populations suggesting the involvement of this transcription factor in diabetes ..
  58. ncbi The functional Thr130Ile and Val255Met polymorphisms of the hepatocyte nuclear factor-4alpha (HNF4A): gene associations with type 2 diabetes or altered beta-cell function among Danes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 6, NSK1 14, DK 2820 Gentofte, Denmark
    J Clin Endocrinol Metab 90:3054-9. 2005
    b>HNF4A encodes an orphan nuclear receptor that plays crucial roles in regulating hepatic gluconeogenesis and insulin secretion...
  59. pmc Variants in hepatocyte nuclear factor 4alpha are modestly associated with type 2 diabetes in Pima Indians
    Yunhua Li Muller
    Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, AZ 85016, USA
    Diabetes 54:3035-9. 2005
    Single nucleotide polymorphisms (SNPs) within the hepatocyte nuclear factor 4alpha (HNF4alpha) gene are associated with type 2 diabetes in Finns and Ashkenazi Jews...
  60. ncbi A novel -192c/g mutation in the proximal P2 promoter of the hepatocyte nuclear factor-4 alpha gene (HNF4A) associates with late-onset diabetes
    Jakob Ek
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    Diabetes 55:1869-73. 2006
    Recently, it has been shown that mutations in the P2 promoter of the hepatocyte nuclear factor (HNF)-4 alpha gene (HNF4A) cause maturity-onset diabetes of the young (MODY), while single nucleotide polymorphisms in this locus are ..
  61. pmc Macrosomia and hyperinsulinaemic hypoglycaemia in patients with heterozygous mutations in the HNF4A gene
    Ewan R Pearson
    Peninsula Medical School, Exeter, United Kingdom
    PLoS Med 4:e118. 2007
    ..hypoglycaemia in patients with heterozygous mutations in the maturity-onset diabetes of the young (MODY) genes HNF4A (encoding HNF-4alpha) and HNF1A/TCF1 (encoding HNF-1alpha), and the effect of pancreatic deletion of Hnf4a on ..
  62. ncbi Association testing of variants in the hepatocyte nuclear factor 4alpha gene with risk of type 2 diabetes in 7,883 people
    Wendy Winckler
    Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Diabetes 54:886-92. 2005
    ..reported association of common polymorphisms in the P2 promoter of hepatocyte nuclear factor 4alpha (HNF4alpha) (the MODY1 gene) with risk for type 2 diabetes...
  63. ncbi Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection
    E R Pearson
    Diabetes and Vascular Medicine, Institute of Biomedical and Clinical Science, Peninsula Medical School, Barrack Road, Exeter EX2 5AX, UK
    Diabetologia 48:878-85. 2005
    ..the gene of the transcription factor hepatocyte nuclear factor 4alpha (HNF-4alpha) are considered a rare cause of MODY with only 14 mutations reported to date. The description of the phenotype is limited to single families...
  64. ncbi Genetic analysis of HNF4A polymorphisms in Caucasian-American type 2 diabetes
    Allison M Bagwell
    Molecular Genetics Program, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes 54:1185-90. 2005
    Hepatocyte nuclear factor 4alpha (HNF4A), the gene for the maturity-onset diabetes of the young type 1 monogenic form of type 2 diabetes, is within the type 2 diabetes-linked region on chromosome 20q12-q13...
  65. ncbi Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
    Wendy Winckler
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Diabetes 56:685-93. 2007
    ..12 and a P value <10(-6) in >15,000 samples. We combined these results with our previous studies on HNF4alpha and TCF1 and explicitly tested for gene-gene interactions among these variants and with several known type 2 ..
  66. ncbi Polymorphisms in both promoters of hepatocyte nuclear factor 4-alpha are associated with type 2 diabetes in the Amish
    Coleen M Damcott
    Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Diabetes 53:3337-41. 2004
    Hepatocyte nuclear factor 4-alpha (HNF4A) is a transcription factor located on chromosome 20q13 that regulates expression of genes involved in glucose metabolism and homeostasis...
  67. pmc A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene
    Kwang Hoon Song
    Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio University College of Medicine, 4209 State Route 44, Rootstown, OH 44272, USA
    J Biol Chem 281:10081-8. 2006
    ..a specific interaction between the N-terminal LXXLL motif of Prox1 and the activation function 2 domain of HNF4alpha. Prox1 strongly inhibited HNF4alpha and peroxisome proliferators-activated receptor gamma coactivator-1alpha co-..
  68. ncbi E-cadherin-dependent transcriptional control of apolipoprotein A-IV gene expression in intestinal epithelial cells: a role for the hepatic nuclear factor 4
    Gregory Peignon
    Université Pierre et Marie Curie UMRS 505, Paris, F 75006 France, INSERM, UMRS 505, F 75006 Paris, France
    J Biol Chem 281:3560-8. 2006
    ..Altogether, our results suggest that E-cadherin controls enterocyte-specific expression of genes, such as the apoA-IV gene, through the control of hepatic nuclear factor 4alpha nuclear abundance...
  69. ncbi Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population
    Kazuo Hara
    Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Diabetes 55:1260-4. 2006
    ..type 2 diabetic sibpairs, we observed linkage of type 2 diabetes to chromosome 20q12-q13, a region in which the HNF4A gene is located...
  70. ncbi Clinical characteristics, beta-cell function, HLA class II and mutations in MODY genes in non-paediatric subjects with Type 1 diabetes without pancreatic autoantibodies
    E Aguilera
    Endocrinology and Diabetes Unit, IDIBAPS, Hospital Clinic i Universitari, Barcelona, Spain
    Diabet Med 22:137-43. 2005
    ..To study clinical characteristics, beta-cell function, HLA typing and mutations in the hepatocyte nuclear factor (HNF)-1alpha and HNF-4alpha genes in Type 1 diabetes mellitus (T1D) patients without pancreatic autoantibodies...
  71. ncbi Variation near the hepatocyte nuclear factor (HNF)-4alpha gene associates with type 2 diabetes in the Danish population
    S K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Niels Steensens Vej 2, Gentofte, 2820, Copenhagen, Denmark
    Diabetologia 48:452-8. 2005
    ..The gene encoding HNF-4alpha (HNF4A) is located on chromosome 20q12-q13 in a region that in several studies has shown linkage with type 2 diabetes...
  72. ncbi Association study on chromosome 20q11.21-13.13 locus and its contribution to type 2 diabetes susceptibility in Japanese
    Toshihito Tanahashi
    Division of Genetic Information, Institute for Genome Research, The University of Tokushima, 3 18 15, Tokushima, Japan
    Hum Genet 120:527-42. 2006
    ..31-Mb region (20q11.21-13.13), which contained 291 genes, including hepatocyte nuclear factor 4alpha (HNF4alpha). As a result, a total of 1,147 SNPs were genotyped with TaqMan assay using 1,818 Japanese samples...
  73. ncbi Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:1141-9. 2004
    ..3 kb downstream of the primary beta-cell promoter P2 of hepatocyte nuclear factor-4 alpha (HNF4A). This SNP showed association with diabetes disease status (odds ratio [OR] 1.33, 95% CI 1.06-1.65, P = 0...
  74. ncbi Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids
    G Bruce Wisely
    GlaxoSmithKline Inc, 5 Moore Drive, Research Triangle Park, NC 27709, USA
    Structure 10:1225-34. 2002
    ..GC/MS and NMR analysis of chloroform/methanol extracts from purified HNF4alpha and HNF4gamma LBDs identified mixtures of saturated and cis-monounsaturated C14-18 fatty acids...
  75. ncbi Thyroid hormone receptor interacting protein 3 (trip3) is a novel coactivator of hepatocyte nuclear factor-4alpha
    Hiromi Iwahashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan
    Diabetes 51:910-4. 2002
    ..nuclear factor-4alpha (HNF-4alpha) gene are associated with a subtype of maturity-onset diabetes of the young (MODY1) that is characterized by impaired insulin secretion in response to a glucose load...
  76. ncbi Analysis of gene expression profile induced by hepatocyte nuclear factor 4alpha in hepatoma cells using an oligonucleotide microarray
    Takafumi Naiki
    First Department of Internal Medicine and the Department of Neurology and Psychiatry, Gifu University School of Medicine, Gifu, Japan
    J Biol Chem 277:14011-9. 2002
    ..This cDNA microarray analysis showed that HNF-4alpha is one of the central liver metabolism regulators...
  77. pmc A transcription factor regulatory circuit in differentiated pancreatic cells
    S F Boj
    Endocrinology and Hormonal Biochemistry Units, Hospital Clinic Universitari, Institut d Investigacions Biomediques August Pi i Sunyer, Villarroel 170, 08036 Barcelona, Spain
    Proc Natl Acad Sci U S A 98:14481-6. 2001
    ..In hepatocytes, hnf4alpha controls the transcription of hnf1alpha, suggesting that this same interaction may operate in beta cells and ..
  78. pmc Population-specific risk of type 2 diabetes conferred by HNF4A P2 promoter variants: a lesson for replication studies
    Ines Barroso
    Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Diabetes 57:3161-5. 2008
    Single nucleotide polymorphisms (SNPs) in the P2 promoter region of HNF4A were originally shown to be associated with predisposition for type 2 diabetes in Finnish, Ashkenazi, and, more recently, Scandinavian populations, but they ..
  79. pmc The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism
    M Stoffel
    Laboratory of Metabolic Diseases, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 94:13209-14. 1997
    Hepatocyte nuclear factor 4alpha (HNF4alpha) plays a critical role in regulating the expression of many genes essential for normal functioning of liver, gut, kidney, and pancreatic islets...
  80. pmc DAX-1 acts as a novel corepressor of orphan nuclear receptor HNF4alpha and negatively regulates gluconeogenic enzyme gene expression
    Balachandar Nedumaran
    Hormone Research Center, School of Biological Science and Technology, Chonnam National University, Gwangju 500 757, South Korea
    J Biol Chem 284:27511-23. 2009
    ..b>HNF4alpha (hepatocyte nuclear factor 4alpha) is a liver-enriched transcription factor that controls the expression of a ..
  81. ncbi Studies of the genetic variability of the coding region of the hepatocyte nuclear factor-4alpha in Caucasians with maturity onset NIDDM
    A M Møller
    Steno Diabetes Center and Hagedorn Research Institute, Copenhagen, Denmark
    Diabetologia 40:980-3. 1997
    ..hepatocyte nuclear factor-4alpha (HNF-4alpha) gene cause the type 1 form of maturity onset diabetes of the young (MODY1)...
  82. pmc Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function
    Sara K Hansen
    Steno Diabetes Center and Hagedorn Research Institute, Gentofte, Denmark
    J Clin Invest 110:827-33. 2002
    ..6 kb upstream from the previously characterized Hnf4alpha promoter (P1)...
  83. doi HNF4 alpha and the Ca-channel TRPC1 are novel disease candidate genes in diabetic nephropathy
    Monika Niehof
    Fraunhofer Institute of Toxicology and Experimental Medicine, Center of Molecular Medicine and Medical Biotechnology, Nikolai Fuchs Str 1, 30625 Hannover, Germany
    Diabetes 57:1069-77. 2008
    The nuclear receptor hepatic nuclear factor 4 alpha (HNF 4 alpha) is a master regulatory protein and an essential player in the control of a wide range of metabolic processes...
  84. ncbi Hepatocyte nuclear factor-4 is a novel downstream target of insulin via FKHR as a signal-regulated transcriptional inhibitor
    Keiko Hirota
    Center of Tsukuba Advanced Research Alliance, Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    J Biol Chem 278:13056-60. 2003
    ..These results suggest that insulin regulates the transcriptional activity of HNF-4 via FKHR as a signal-regulated transcriptional inhibitor...
  85. ncbi A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population
    Latisha D Love-Gregory
    Division of Endocrinology, Diabetes and Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 53:1134-40. 2004
    Variants in hepatocyte nuclear factor-4 alpha (HNF4 alpha), a transcription factor that influences the expression of glucose metabolic genes, have been correlated with maturity-onset diabetes of the young, a monogenic form of diabetes...
  86. pmc Control of pancreas and liver gene expression by HNF transcription factors
    Duncan T Odom
    Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 303:1378-81. 2004
    ..promoter microarrays to identify systematically the genes occupied by the transcriptional regulators HNF1alpha, HNF4alpha, and HNF6, together with RNA polymerase II, in human liver and pancreatic islets...
  87. ncbi Studies in 3,523 Norwegians and meta-analysis in 11,571 subjects indicate that variants in the hepatocyte nuclear factor 4 alpha (HNF4A) P2 region are associated with type 2 diabetes in Scandinavians
    Stefan Johansson
    Department of Clinical Medicine, University of Bergen, Bergen, Norway
    Diabetes 56:3112-7. 2007
    Recent publications have found an association between common variants near the hepatocyte nuclear factor 4 alpha (HNF4A) P2 promoter and type 2 diabetes in some populations but not in others, and the role for HNF4A in type 2 diabetes has ..
  88. ncbi Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
    K Yamagata
    Howard Hughes Medical Institute, The University of Chicago, Illinois 60637, USA
    Nature 384:458-60. 1996
    ..Linkage studies have localized the genes that are mutated in MODY on human chromosomes 20 (MODY1), 7 (MODY2) and 12 (MODY3), with MODY2 and MODY3 being allelic with the genes encoding glucokinase, a key ..
  89. ncbi Role of human hepatocyte nuclear factor 4alpha in the expression of drug-metabolizing enzymes and transporters in human hepatocytes assessed by use of small interfering RNA
    Yoshiteru Kamiyama
    Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Drug Metab Pharmacokinet 22:287-98. 2007
    Hepatocyte nuclear factor 4alpha (HNF4alpha) is an important transcription factor in hepatic gene expression...
  90. ncbi Gene-gene interactions between HNF4A and KCNJ11 in predicting Type 2 diabetes in women
    L Qi
    Department of Nutrition, Harvard Medical School of Public Health, Boston, MA 02115, USA
    Diabet Med 24:1187-91. 2007
    Recent studies indicate transcription factor hepatocyte nuclear factor 4 alpha (HNF-4 alpha, HNF4A) modulates the transcription of the pancreatic B-cell ATP-sensitive K+ (KATP) channel subunit Kir6.2 gene (KCNJ11)...
  91. ncbi Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven isoforms
    J Eeckhoute
    Institut National de la Santé et de la Recherche Médicale Unit 459, Faculté H Warembourg, Lille, France
    Endocrinology 144:1686-94. 2003
    ..Mutations in the HNF4 alpha gene are correlated with maturity-onset diabetes of the young 1...
  92. ncbi Macrosomia and neonatal hypoglycaemia in RW pedigree subjects with a mutation (Q268X) in the gene encoding hepatocyte nuclear factor 4alpha (HNF4A)
    S S Fajans
    Diabetologia 50:2600-1. 2007
  93. ncbi [Genetics of type II diabetes]
    P Froguel
    Institut de biologie-CNRS 8090, Institut Pasteur de Lille, rue du Professeur-Calmette, BP 245, 59019 Lille
    Arch Mal Coeur Vaiss 93:7-12. 2000
    ..largely elucidated in the last years by the identification of the 5 genes responsible for the autosomal dominant MODY subtype: glucokinase, and 4 transcription factors which play a key role in the development of the endocrine ..
  94. pmc Beta-catenin-histone deacetylase interactions regulate the transition of LEF1 from a transcriptional repressor to an activator
    A N Billin
    Huntsman Cancer Institute, University of Utah, Salt Lake City 84112 5550, USA
    Mol Cell Biol 20:6882-90. 2000
    Recent evidence suggests that certain LEF/TCF family members act as repressors in the absence of Wnt signaling. We show here that repression by LEF1 requires histone deacetylase (HDAC) activity...
  95. ncbi Genetics of type 2 diabetes mellitus
    Maciej T Malecki
    Department of Metabolic Diseases, Medical College, Jagiellonian University, 15 Kopernika Street, 31 501 Krakow, Poland
    Diabetes Res Clin Pract 68:S10-21. 2005
    ..forms of T2DM with profound defect in insulin secretion include subtypes of maturity onset diabetes of the young (MODY), maternally inherited diabetes with deafness (MIDD) caused by mitochondrial mutations, and rare cases resulting ..
  96. pmc HNF4beta, a new gene of the HNF4 family with distinct activation and expression profiles in oogenesis and embryogenesis of Xenopus laevis
    B Holewa
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Germany
    Mol Cell Biol 17:687-94. 1997
    ..This new gene was named HNF4beta to distinguish it from the known HNF4 gene, which is now called HNF4alpha. By reverse transcription-PCR, we detected within the 5' untranslated region of HNF4beta two splice variants (..
  97. doi Effect of hen's egg yolk on capacitation and acrosome reaction of diluted canine spermatozoa
    T S Witte
    Centre for Artificial Insemination and Embryo Transfer, University of Veterinary Science Vienna, Veterinarplatz 1, A 1210 Vienna, Austria
    Anim Reprod Sci 110:293-305. 2009
    ..For this purpose, we first investigated the effect of supplementation of a Tris-citrate-fructose buffer (TCF) with progesterone in a final concentration of 0.1, 0.2 and 1.0 microg progesterone/ml TCF-diluted semen...
  98. pmc Loss of expression of the WNT/beta-catenin-signaling pathway transcription factors lymphoid enhancer factor-1 (LEF-1) and T cell factor-1 (TCF-1) in a subset of peripheral T cell lymphomas
    David M Dorfman
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Pathol 162:1539-44. 2003
    T cell factor-1 (TCF-1) and lymphoid enhancer factor-1 (LEF-1), members of the TCF/LEF family of transcription factors, play a significant role in T cell development and are expressed in thymocytes and peripheral CD3+ T cells...
  99. doi Paneth cell differentiation in colonic epithelial neoplasms: evidence for the role of the Apc/beta-catenin/Tcf pathway
    Mee Joo
    Department of Pathology, Inje University Ilsan Paik Hospital, Daehwa dong, Ilsanseo gu, Goyang si, Gyeonggi Do, Republic of Korea
    Hum Pathol 40:872-80. 2009
    ..a specific marker of Paneth cells and has been shown to represent one of the target genes of the Apc/beta-catenin/Tcf pathway...
  100. doi Assessing lethal and sub-lethal effects of trichlorfon on different trophic levels
    Sónia Coelho
    CESAM and Department of Biology, University of Aveiro, 3810 193 Aveiro, Portugal
    Aquat Toxicol 103:191-8. 2011
    Trichlorfon (TCF) is one of the most used veterinary pharmaceuticals not only to fight infestations but also as a preventive measure worldwide. The high concentrations used generate concerns about environmental and human health...
  101. pmc Voltage and temperature dependence of single K+ channels isolated from canine cardiac sarcoplasmic reticulum
    W K Shen
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27710
    Biophys J 65:747-54. 1993
    ..b>Tcf was voltage insensitive with an average value of 5...

Research Grants65

  1. The role of Pdcd4 in colorectal tumor progression
    Hsin Sheng Yang; Fiscal Year: 2010
    ..cells and found that Pdcd4 knock-down triggers morphological changes, induces invasion, and activates 2-catenin/Tcf and AP-1 dependent transcription...
  2. GENES FOR NONINSULIN-DEPENDENT DIABETES MELLITUS
    GRAEME BELL; Fiscal Year: 1993
    ..have seen great progress in our understanding of the molecular genetics of maturity-onset diabetes of the young (MODY), an uncommon form of NIDDM characterized by onset usually before age of 25 years and an autosomal dominant mode of ..
  3. GENES FOR NONINSULIN DEPENDENT DIABETES MELLITUS
    GRAEME BELL; Fiscal Year: 1999
    ..have seen great progress in our understanding of the molecular genetics of maturity-onset diabetes of the young (MODY), an uncommon form of NIDDM characterized by onset usually before age of 25 years and an autosomal dominant mode of ..
  4. Analysis of intestinal genes regulated by the transcription factor CDX2
    Ramesh A Shivdasani; Fiscal Year: 2010
    ..We also find significant co-occupancy of the nuclear receptor HNF4) near CDX2-activated genes and of GATA proteins near genes that CDX2 appears to repress...
  5. Structure and Function of DNA-Regulatory Proteins
    Ronen Marmorstein; Fiscal Year: 2005
    ..To address the second question, we will focus on a group of mammalian ternary complex factors (TCF's) that contain a conserved ETS DNA-binding domain and that interact with DNA bound serum response factor (SRF) at ..
  6. METABOLISM OF ISLETS OF LANGERHANS AND HORMONE RELEASE
    Franz Matschinsky; Fiscal Year: 2002
    ..b>MODY-2 and hyperinsulinemias linked to glucokinase (HI-GK) or glutamate dehydrogenase (HI-GDH) mutations are the ..
  7. The role of Pdcd4 in colorectal tumor progression
    Hsin Sheng Yang; Fiscal Year: 2011
    ..cells and found that Pdcd4 knock-down triggers morphological changes, induces invasion, and activates 2-catenin/Tcf and AP-1 dependent transcription...
  8. Regulation of Bile Acid Synthesis by Nuclear Receptors
    JOHN CHIANG; Fiscal Year: 2006
    ..SHP interacts with either alpha-fetoprotein transcription factor (FTF) and/or hepatocyte nuclear factor4 (HNF4) and represses CYP7A1 transcription...
  9. MOLECULAR-NUTRIENT INTERACTIONS IN INTESTINAL CANCER
    Leonard Augenlicht; Fiscal Year: 2007
    ..determine how the genetic and dietary factors, alone and in combination, recruit and modulate the b-catenin-Tcf -- c-myc/cyclinD1 -- cdk4/p21/p27 pathway, and Augenlicht, L related signaling and cell cycle machinery...
  10. Beta-Catenin/TCF Signaling in Breast Cancer
    Louise R Howe; Fiscal Year: 2010
    ..We hypothesize that beta-catenin/TCF signaling may be a novel target for breast cancer prevention...
  11. HYPERTENSION IN AFRICAN-AMERICAN WOMEN
    Ashok Kumar; Fiscal Year: 2004
    ..The human AG gene is primarily expressed in the liver and we have shown that liver enriched transcription factors HNF4 and DBP, and ubiquitous transcription factors SP1 and CREB play important role in liver specific expression of this ..
  12. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2009
    ..or cancer-related mutations leads to beta-catenin nuclear accumulation and its enhanced binding to T cell factor (TCF) family of transcription factors...
  13. The Role of Beta-catenin/Tcf Pathway Defects in Cancer
    Eric Fearon; Fiscal Year: 2007
    ..or cancer-related mutations leads to beta-catenin nuclear accumulation and its enhanced binding to T cell factor (TCF) family of transcription factors...
  14. Hhex-a Homeobox Gene Necessary for Liver Development
    Clifford W Bogue; Fiscal Year: 2010
    ..Furthermore, we showed that deletion of Hhex is associated with decreased expression of Hnf4a, Hnf1b (TCF2) and Onecut1 (Hnf6), suggesting that Hhex regulates, either directly or indirectly, the expression of ..
  15. Hhex-a Homeobox Gene Necessary for Liver Development
    CLIFFORD BOGUE; Fiscal Year: 2009
    ..Furthermore, we showed that deletion of Hhex is associated with decreased expression of Hnf4a, Hnf1b (TCF2) and Onecut1 (Hnf6), suggesting that Hhex regulates, either directly or indirectly, the expression of ..
  16. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert I Glazer; Fiscal Year: 2010
    ..hypothesis that 3-phosph6inbsitide-dependent protein kinase-1 (PDK1) activates and interacts with the ff-eaten in/TCF-target gene, peroxisome proliferator-activated receptor-delta (PPARtf). to promote mammary tumorigenesis...
  17. PDK1 and PPARdelta Signaling in Mammary Tumorigenesis
    Robert Glazer; Fiscal Year: 2009
    ..hypothesis that 3-phosph6inbsitide-dependent protein kinase-1 (PDK1) activates and interacts with the ff-eaten in/TCF-target gene, peroxisome proliferator-activated receptor-delta (PPARtf). to promote mammary tumorigenesis...
  18. Beta-catenin-specific regulation of the vitamin D pathway in colon cancer
    Stephen W Byers; Fiscal Year: 2010
    ..Preliminary data demonstrates that the wnt/2- catenin/TCF oncogenic pathway, almost universally activated in colon cancer, is a key intermediary in the preventive action of ..