HNF1B

Summary

Gene Symbol: HNF1B
Description: HNF1 homeobox B
Alias: FJHN, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1, HNF-1-beta, HNF1 beta A, hepatocyte nuclear factor 1-beta, homeoprotein LFB3, transcription factor 2, hepatic
Species: human

Top Publications

  1. ncbi Enlarged nephrons and severe nondiabetic nephropathy in hepatocyte nuclear factor-1beta (HNF-1beta) mutation carriers
    Jørn V Sagen
    Department of Pediatrics, Center for Genetics and Molecular Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Kidney Int 64:793-800. 2003
  2. ncbi Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor
    Harry A Otun
    School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Soc Gynecol Investig 12:185-90. 2005
  3. ncbi Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41
    Katerina Hodanova
    Center for Applied Genomics, Institute for Inherited Metabolic Disorders, Charles University 1st School of Medicine, Prague, Czech Republic
    Kidney Int 68:1472-82. 2005
  4. ncbi Multiple newly identified loci associated with prostate cancer susceptibility
    Rosalind A Eeles
    The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Nat Genet 40:316-21. 2008
  5. pmc Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma
    Akira Tsuchiya
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 163:2503-12. 2003
  6. pmc Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies
    Katherine S Elliott
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10858. 2010
  7. ncbi Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease
    Emma L Edghill
    1Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Nephrol Dial Transplant 23:627-35. 2008
  8. pmc Gene expression profiling predicts clinical outcome of prostate cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Clin Invest 113:913-23. 2004
  9. doi Transcription factor HNF1beta and novel partners affect nephrogenesis
    Karin Dudziak
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    Kidney Int 74:210-7. 2008
  10. pmc Genome-wide association study identifies a common variant associated with risk of endometrial cancer
    Amanda B Spurdle
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:451-4. 2011

Research Grants

Detail Information

Publications189 found, 100 shown here

  1. ncbi Enlarged nephrons and severe nondiabetic nephropathy in hepatocyte nuclear factor-1beta (HNF-1beta) mutation carriers
    Jørn V Sagen
    Department of Pediatrics, Center for Genetics and Molecular Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Kidney Int 64:793-800. 2003
    ..lead to a syndrome with diabetes and urogenital malformations [maturity onset of diabetes of the young, type 5 (MODY5)]...
  2. ncbi Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor
    Harry A Otun
    School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Soc Gynecol Investig 12:185-90. 2005
    ....
  3. ncbi Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41
    Katerina Hodanova
    Center for Applied Genomics, Institute for Inherited Metabolic Disorders, Charles University 1st School of Medicine, Prague, Czech Republic
    Kidney Int 68:1472-82. 2005
    ..and progressive renal insufficiency are features associated with familial juvenile hyperuricemic nephropathy (FJHN), medullary cystic kidney disease type 1 (MCKD1) and type 2 (MCKD2). MCKD1 has been mapped to chromosome 1q21...
  4. ncbi Multiple newly identified loci associated with prostate cancer susceptibility
    Rosalind A Eeles
    The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Nat Genet 40:316-21. 2008
    ..7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3...
  5. pmc Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma
    Akira Tsuchiya
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 163:2503-12. 2003
    ..Our results suggest that HNF-1 beta is not only an excellent CCC-specific molecular marker but also a molecular target for therapy of ovarian CCC...
  6. pmc Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies
    Katherine S Elliott
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10858. 2010
    Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk...
  7. ncbi Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease
    Emma L Edghill
    1Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Nephrol Dial Transplant 23:627-35. 2008
    ..HNF-1beta gene deletions have recently been shown to cause renal malformations and early-onset diabetes...
  8. pmc Gene expression profiling predicts clinical outcome of prostate cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Clin Invest 113:913-23. 2004
    ....
  9. doi Transcription factor HNF1beta and novel partners affect nephrogenesis
    Karin Dudziak
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    Kidney Int 74:210-7. 2008
    ..Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies of the kidney and urinary tract) gene...
  10. pmc Genome-wide association study identifies a common variant associated with risk of endometrial cancer
    Amanda B Spurdle
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:451-4. 2011
    ..We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7...
  11. pmc HNF1B mutations associate with hypomagnesemia and renal magnesium wasting
    Shazia Adalat
    Nephrology Unit, Great Ormond Street Hospital NHS Trust, London WCIN 3JH, UK
    J Am Soc Nephrol 20:1123-31. 2009
    Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcription factor expressed in tissues including renal epithelia, associate with abnormal renal development...
  12. pmc Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1
    Alexander J Michels
    Linus Pauling Institute and the Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
    Am J Physiol Cell Physiol 297:C1220-7. 2009
    ..Together, these data suggest that HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression and may be involved in the coordinate regulation of whole body vitamin C status...
  13. ncbi Renal cysts and diabetes syndrome linked to mutations of the hepatocyte nuclear factor-1 beta gene: description of a new family with associated liver involvement
    Alberto Montoli
    Renal Unit, Niguarda Ca Granda Hospital, Milan, Italy
    Am J Kidney Dis 40:397-402. 2002
    Mutations in the hepatocyte nuclear factor (HNF)-1beta gene (TCF2) are responsible for a syndrome characterized by maturity-onset diabetes of the young, a nondiabetic renal disease, genital malformations, and liver dysfunction.
  14. doi Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation
    Li Jin
    Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Pharmacol Exp Ther 340:648-55. 2012
    ....
  15. doi Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis
    Fadi Brimo
    Department of Pathology, Johns Hopkins Hospital Medical Institutions, Baltimore, MD 21287, USA
    Hum Pathol 42:1613-9. 2011
    ....
  16. ncbi Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic development
    E L Edghill
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabet Med 23:1301-6. 2006
    ..We aimed to investigate the role of HNF-1beta mutations in neonatal diabetes and also the impact of HNF-1beta mutations on fetal growth...
  17. pmc Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 40:1153-5. 2008
    We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci ..
  18. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.
  19. pmc Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population
    Congrong Wang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
    Diabetes 58:1023-7. 2009
    Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis...
  20. ncbi Cell-specific involvement of HNF-1beta in alpha(1)-antitrypsin gene expression in human respiratory epithelial cells
    Chaobin Hu
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 282:L757-65. 2002
    ..These results indicate the unique involvement of HNF-1beta in alpha(1)-AT gene expression in a cell line and primary cultures derived from human respiratory epithelium...
  21. pmc Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancer
    Peng Liu
    Departments of Experimental Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 69:4843-50. 2009
    ..Here, we show that variant hepatic nuclear factor 1 (vHNF1), encoded by transcription factor 2 gene (TCF2, HNF1beta), negatively regulates HSulf-1 expression in ovarian cancer...
  22. ncbi Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2 on 17q); P < 10(-10))...
  23. ncbi Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations
    Christine Bellanne-Chantelot
    Fédération des Services de Biochimie, Laboratoire de Biologie Moleculaire, Hopital Saint Antoine, Paris, France
    Ann Intern Med 140:510-7. 2004
    Maturity-onset diabetes of the young type 5 (MODY5), a type of dominantly inherited diabetes mellitus and nephropathy, has been associated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene, mostly generating ..
  24. ncbi Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations
    Ewan R Pearson
    Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK
    Diabetes Care 27:1102-7. 2004
    ..However, physiological assessment of the HNF-1beta phenotype is limited. We aimed to test the hypothesis that the diabetes phenotype due to HNF-1beta mutations is similar to that in HNF-1alpha...
  25. ncbi Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
    Wendy Winckler
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Diabetes 56:685-93. 2007
    ..Specifically, we determined patterns of common sequence variation in the genes encoding Gck, Ipf1, Tcf2, and NeuroD1 (MODY2 and MODY4-MODY6, respectively), selected a comprehensive set of 107 tag single nucleotide ..
  26. doi Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
    Johan Holmkvist
    Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Diabetes 57:1738-44. 2008
    ....
  27. ncbi HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
    D B Mendel
    Beckman Center for Molecular and Genetic Medicine, Howard Hughes Medical Institute, Stanford University Medical School, California 94305
    Genes Dev 5:1042-56. 1991
    ..These studies define a pair of homeo domain proteins that have the potential to interact to produce an embryologically complex pattern of gene expression...
  28. pmc More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing
    I Bach
    Unite des Virus Oncogenes, UA 1644 du CNRS, Departement des Biotechnologies, Institut Pasteur, Paris, France
    EMBO J 12:4229-42. 1993
    ..of cDNAs from human liver encoding several isoforms of the hepatocyte nuclear factor homeoproteins HNF1 and vHNF1 generated by the differential use of polyadenylation sites and by alternative splicing...
  29. ncbi Scanning for MODY5 gene mutations in Chinese early onset or multiple affected diabetes pedigrees
    C Wang
    Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai No 6 People s Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China
    Acta Diabetol 41:137-45. 2004
    ..of HNF-1beta gene has been reported in early onset diabetes or MODY families and this gene has been defined as MODY5 gene...
  30. ncbi Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY
    Y Horikawa
    Nat Genet 17:384-5. 1997
  31. ncbi Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
    ..One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5...
  32. ncbi Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta
    C Bingham
    Department of Vascular Medicine and Diabetes Research, School of Postgraduate Medicine and Health Sciences, University of Exeter, England, United Kingdom
    Kidney Int 57:898-907. 2000
    ..HNF-1 beta gene mutations are associated with a unique disorder characterized by maturity-onset diabetes of the young (MODY) and early-onset and progressive nondiabetic renal dysfunction, which may lead to chronic renal failure...
  33. ncbi pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) s
    R J Lee
    Departments of Developmental and Molecular Biology and Medicine, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 274:7341-50. 1999
    ..Induction of cyclin D1 activity by pp60(v-src) may contribute to breast tumorigenesis through phosphorylation and inactivation of the retinoblastoma protein...
  34. ncbi Evolutionary significance of intra-genome duplications on human chromosomes
    T Endo
    Center for Information Biology, National Institute of Genetics, Mishima, Shizuoka, Japan
    Gene 205:19-27. 1997
    ..We also propose that a comparative mapping of paralogous genes within the human genome would be useful for identifying new genes...
  35. ncbi p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription fact
    Narayan R Bhat
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 277:29584-92. 2002
    ....
  36. ncbi [Effects of Qishe Pill on vertebral hyperostosis induced by upright posture in rats]
    Qin Bian
    Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    Zhong Xi Yi Jie He Xue Bao 8:173-80. 2010
    ..To observe the effects of Qishe Pill, a compound traditional Chinese herbal medicine, on lumbar vertebral bone formation induced by long-time upright posture in rats and to investigate the potential mechanism...
  37. ncbi High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells
    Tusty Jiuan Hsieh
    Université de Montréal Centre hospitalier de l Université de Montréal Hôtel Dieu, Centre de Recherche Pavillon Masson, Montreal, Quebec, Canada H2W 1T8
    Endocrinology 144:4338-49. 2003
    ..Our studies demonstrate that the stimulatory effect of high glucose on ANG gene expression and IRPTC hypertrophy may be mediated at least in part via activation of hexosamine biosynthesis pathway signaling...
  38. ncbi Changes in expression of p38 mitogen-activated protein kinase in the dorsal motor nucleus of the vagus nerve and hypoglossal nucleus after axotomy in adult rats
    Tatsuo Shimokawara
    Department of Pathology, Nara Medical University, Kashihara, Japan
    Neuropathology 22:261-8. 2002
    ..Moreover, perineuronal microglial cells showed strong expression of p38 MAP kinase, active and inactive, after axotomy in both nuclei. These findings suggest that p38 MAP kinase is related to microglial cell reactions after axotomy...
  39. ncbi Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer
    R Hara
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 274:24779-86. 1999
    ....
  40. ncbi Towards the identification of (a) gene(s) for autosomal dominant medullary cystic kidney disease
    Francesco Scolari
    Division and Chair of Nephrology, Spedali Civili, Brescia, Italy
    J Nephrol 16:321-8. 2003
    ..The gene for familial juvenile hyperuricemic nephropathy (FJHN), a phenotype that is very similar to MCKD, was recently mapped to 16p12, in a region overlapping with the MCKD2 ..
  41. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
    ..This study shows that a general transcription factor, TFIIA gamma, facilitates osteoblast-specific gene expression through interactions with two important bone transcription factors ATF4 and Runx2...
  42. ncbi The osteoinductive properties of Nell-1 in a rat spinal fusion model
    Steven S Lu
    Dental and Craniofacial Research Institutes, UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Spine J 7:50-60. 2007
    ..Previous studies showed that Nell-1 accelerates osteogenic differentiation in vitro and calvarial bone formation in vivo. We hypothesize that Nell-1 may also effectively form bone in spinal fusion...
  43. doi Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells
    Hassan El Btaouri
    Laboratoire SiRMa Signalisation Cellulaire et Récepteurs Matriciels, UMR CNRS 6237, UFR Sciences, Reims, France
    Biochim Biophys Acta 1813:695-703. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  44. pmc Differential expression of activating transcription factor-2 and c-Jun in the immature and adult rat hippocampus following lithium-pilocarpine induced status epilepticus
    Si Ryung Han
    Department of Neurology, The Catholic University of Korea, Seoul, Korea
    Yonsei Med J 50:200-5. 2009
    ..Therefore, we investigated the expression of c-Jun and ATF-2 protein in the immature and adult rat hippocampus to understand their roles in LPSE-induced neuronal death...
  45. doi Response of human alveolar bone-derived cells to a novel poly(vinylidene fluoride-trifluoroethylene)/barium titanate membrane
    L N Teixeira
    Department of Morphology, Stomatology and Physiology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Mater Sci Mater Med 22:151-8. 2011
    ..Further in vivo experiments should be carried out to confirm the capacity of P(VDF-TrFE)/BT membrane in promoting bone formation in guided bone regeneration...
  46. ncbi Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors
    D J Kroll
    Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262
    Mol Endocrinol 7:305-18. 1993
    ....
  47. ncbi The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect
    M T F Wolf
    Department of Pediatric Nephrology of the University Children s Hospital, University of Cologne, Cologne, Germany
    Kidney Int 71:574-81. 2007
    ..in the Uromodulin (UMOD) gene were published in patients with familial juvenile hyperuricemic nephropathy (FJHN) and MCKD2. Clinical data and blood samples of 16 affected individuals from 11 different kindreds were collected...
  48. pmc Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
    Junzo Hisatsune
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Immunol 180:5017-27. 2008
    ..Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappaB...
  49. doi Role of nutritional zinc in the prevention of osteoporosis
    Masayoshi Yamaguchi
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 338:241-54. 2010
    ..Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis...
  50. pmc Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells
    Lan Xiao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 18:4579-90. 2007
    ..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...
  51. ncbi Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain
    S Brecht
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105, Kiel, Germany
    Neuroscience 120:1037-48. 2003
    ..However, changes of FKBP enzymatic activity result in suppression of the stress cell body response in the peri-infarct area as observed by suppression of c-Jun phosphorylation and Fas-L expression...
  52. ncbi p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1
    Ming Chang Hu
    Division of Nephrology, Program in Developmental Biology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 279:12051-9. 2004
    ..We conclude that BMP7 stimulates renal epithelial cell morphogenesis via p38(MAPK) and that p38(MAPK) activity is negatively regulated by Smad1...
  53. ncbi Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression
    Harufumi Yamasaki
    Department of Biology, Faculty of Science, Shizuoka University, 836 Oya, Surugaku, Shizuoka City, Shizuoka 422 8529, Japan
    Development 133:4233-43. 2006
    ..biliary cell differentiation and gene expression of the regulatory genes for that differentiation, including Hnf1b and Hnf6...
  54. ncbi Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family
    N Kamatani
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Arthritis Rheum 43:925-9. 2000
    Familial juvenile hyperuricemic nephropathy (FJHN, MIM 162000) is an autosomal-dominant disease characterized by underexcretion-type hyperuricemia, gout, and chronic renal failure...
  55. ncbi The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair
    Jun Hayakawa
    Department of Cancer Gene Therapy, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 278:20582-92. 2003
    ..JNK may be a rational target for sensitizing tumor cells to DNA-damaging chemotherapy agents...
  56. ncbi Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma
    Ying Qiu
    Department of Pathology, Tongji University School of Medicine, Shanghai 200092, China
    Cancer Sci 100:1198-209. 2009
    ..PBX2 is a transcription factor for VCP in NSCLC. Because high levels of PBX2 expression correlated with prognosis of NSCLC, PBX2 could be a target molecule for treatment of NSCLC...
  57. ncbi Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6
    Randolph P Matthews
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 132:5295-306. 2005
    ..with this, reduced vps33b expression was evident in hnf6-deficient larvae and in larvae with mutation of vhnf1, a downstream target of hnf6...
  58. pmc JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters
    Dong Chen
    Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Endocrinol 25:767-75. 2011
    ..3/II via CRE(-211/-199). JunB also activates aromatase promoters I.3/II by maintaining JunD expression. Targeting JunD may abolish aromatase expression selectively in breast cancer tissue...
  59. ncbi Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytes
    Qin Ma
    Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610 0235, USA
    J Cell Biochem 101:477-87. 2007
    ..These data identify the Bcl-2 gene as a novel target of ATF-2 and CREB in growth plate chondrocytes...
  60. ncbi Familial nephropathy associated with hyperuricemia in Spain: our experience with 3 families harbouring a UMOD mutation
    J G Puig
    Division of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
    Nucleosides Nucleotides Nucleic Acids 25:1295-300. 2006
    Since 1993 we have studied 5 Spanish families with familial nephropathy associated with hyperuricemia (FJHN). Among these families, 24 patients have been identified...
  61. ncbi High glucose alters the expression of genes involved in proliferation and cell-fate specification of embryonic neural stem cells
    J Fu
    Molecular Neurobiology Laboratory, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Diabetologia 49:1027-38. 2006
    ....
  62. ncbi Cbfbeta interacts with Runx2 and has a critical role in bone development
    Mondira Kundu
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A26, Bethesda, Maryland 20892, USA
    Nat Genet 32:639-44. 2002
    ..Our findings raise the possibility that mutations in CBFB may be responsible for some cases of cleidocranial dysplasia that are not linked to mutations in RUNX2...
  63. ncbi Runx2 deficiency in chondrocytes causes adipogenic changes in vitro
    Hirayuki Enomoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Cell Sci 117:417-25. 2004
    ..Our findings suggest that these Runx2-dependent functions are mediated, at least in part, by interleukin-11...
  64. pmc Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of Transcription
    Takahito Yamasaki
    Gene Engineering Division, RIKEN BioResource Center, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074
    J Biol Chem 284:8567-81. 2009
    ..Our results suggest that the phosphorylation of ATF-2 at Ser-121 plays a key role in the c-Jun-mediated activation of transcription that occurs in response to TPA...
  65. pmc Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38
    Ted Kamenecka
    Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Jupiter, FL 33458, USA
    J Biol Chem 284:12853-61. 2009
    ....
  66. ncbi Familial juvenile hyperuricemic nephropathy and autosomal dominant medullary cystic kidney disease type 2: two facets of the same disease?
    K Dahan
    Center for Human Genetics, Catholic University of Louvain, Brussels, Belgium
    J Am Soc Nephrol 12:2348-57. 2001
    Familial juvenile hyperuricemic nephropathy (FJHN) is an autosomal dominant disorder heralded by hyperuricemia during childhood; it is characterized by chronic interstitial nephritis, with marked thickening of tubular basement membranes, ..
  67. ncbi A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin
    Karin Dahan
    Universite Catholique de Louvain, Center for Human Genetics, Brussels, Belgium
    J Am Soc Nephrol 14:2883-93. 2003
    Familial juvenile hyperuricemic nephropathy (FJHN [MIM 162000]) is an autosomal-dominant disorder characterized by abnormal tubular handling of urate and late development of chronic interstitial nephritis leading to progressive renal ..
  68. doi vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis
    Ludmilla Lokmane
    UMR7622 CNRS Université Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Development 137:347-57. 2010
    ..Here, we identify the transcription factor vHNF1 (HNF1beta) as a crucial regulator of these early developmental events...
  69. ncbi Monogenic diabetes mellitus in youth. The MODY syndromes
    W E Winter
    Department of Pathology, Immunology, University of Florida College of Medicine, Gainesville, USA
    Endocrinol Metab Clin North Am 28:765-85. 1999
    ..HNF-1 alpha, MODY3), insulin promoter factor-1 (IPF-1, MODY4), and hepatocyte nuclear factor-1 beta (HNF-1 beta, MODY5)...
  70. doi Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    OMICS 12:237-44. 2008
    ..rectifying channel, subfamily J, member 11 gene; PPAR-gamma, peroxisome proliferator activated receptor-gamma; TCF2, transcription factor 2, hepatic; WFS1, Wolfram syndrome 1...
  71. ncbi Sustained increases in activating transcription factor-2 and activator protein-2 in the rat supraoptic nucleus during water deprivation
    Rick B Meeker
    Department of Neurology, University of North Carolina, Chapel Hill, 27599, USA
    Neuroendocrinology 76:111-20. 2002
    ....
  72. doi Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice
    Jing Wei Zhao
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Eur J Neurosci 29:1853-69. 2009
    ..We also observed Olig2(TL)GFAP(+) cells that appeared after injury and before the NG2(+)GFAP(+) phenotype. This suggests that not all astrocytes are derived from an NG2(+) population...
  73. ncbi Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-alpha gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts
    Wissam H Faour
    Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 280:9536-46. 2005
    ..We suggest that egr-1 is an immediate-early PGE2 target gene that may be a key regulatory factor in mediating eicosanoid control of genes involved in the immune and inflammatory responses...
  74. ncbi Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells
    R Firestein
    Center for Gerontology, Allegheny University of the Health Sciences and the Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:5892-902. 1998
    ..d) A proteasome inhibitor delays the down-regulation of ATF2 phophorylation after T cell activation. Taken collectively, these results implicate a role for hUBC9 and the ubiquitin/proteasome pathway in regulation of ATF2 in T cells...
  75. pmc Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT)
    Matthias T F Wolf
    Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
    Pediatr Nephrol 24:55-60. 2009
    ..UMOD transcription is activated by the transcription factor HNF1B. Mutations in HNF1B cause a phenotype similar to FJHN/GCKD but also congenital anomalies of the kidney and the ..
  76. ncbi Molecular markers of early orthodontic tooth movement
    Patricia Joyce Brooks
    Orthodontic Department, Faculty of Dentistry, University of Toronto, Toronto, Canada
    Angle Orthod 79:1108-13. 2009
    ..To understand the molecular basis of early orthodontic tooth movement by looking at the expression of KI-67, runt-related transcription factor 2 (Runx2), and tumor necrosis factor ligand superfamily member 11 (RANKL) proteins...
  77. ncbi Insulin-regulated gene expression
    R M O'Brien
    Department of Molecular Physiology and Biophysics, 761 MRB II, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Biochem Soc Trans 29:552-8. 2001
    ..In addition, in the G6Pase catalytic subunit promoter, hepatocyte nuclear factor 1 ('HNF-1'), acts as an accessory factor to enhance the effect of insulin mediated through the IRS...
  78. pmc Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
    C Haumaitre
    Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:1490-5. 2005
    Heterozygous mutations in the human POU-homeobox TCF2 (vHNF1, HNF1beta) gene are associated with maturity-onset diabetes of the young, type 5, and abnormal urogenital tract development...
  79. ncbi Theoretical investigation of hydrogen bonds between CO and HNF2, H2NF, and HNO
    An Yong Li
    School of Chemistry and Chemical Engineering, Southwestern University, 400715, Chongqing, P R China
    J Phys Chem A 110:10805-16. 2006
    Ab initio quantum mechanics methods were applied to investigate the hydrogen bonds between CO and HNF2, H2NF, and HNO...
  80. ncbi Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
    E Barbacci
    U423 INSERM, Hopital Necker Enfants Malades, France U257 INSERM, ICGM, France
    Development 126:4795-805. 1999
    ..We show that variant Hepatocyte Nuclear Factor 1 (vHNF1), a homeodomain-containing transcription factor first expressed in the primitive endoderm, is required for the ..
  81. doi Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene
    Akiro Higashikawa
    Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 60:166-78. 2009
    ..Aiming at clinical application, this study was undertaken to investigate transcriptional regulation of human type X collagen by RUNX-2 in human cells...
  82. pmc Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer
    H Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Br J Cancer 97:1106-15. 2007
    ..In addition, Runx2 has the potential to regulate the transcription of extracellular matrix modulators such as SPARC and MMP1, thereby influencing the tumour microenvironment...
  83. ncbi Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation
    C Coffinier
    Unite des Virus Oncogenes, CNRS URA 1644, and Unité de Biologie du Développement, CNRS URA 1960, Institut Pasteur, F 75724 Paris Cedex 15, France
    Development 126:4785-94. 1999
    vHNF1/HNF1beta, a member of the divergent HNF1/vHNF1 homeoprotein family, is expressed in polarized epithelia of several adult organs and may participate in controlling the transcription of specific genes...
  84. ncbi Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1
    Anatoliy Kravets
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 279:19916-23. 2004
    ..We propose that increased expression of the protein can be used to alter the gene expression profile in the cell...
  85. pmc Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy
    T C Hart
    University of Pittsburgh, School of Dental Medicine, Division of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Med Genet 39:882-92. 2002
    Medullary cystic kidney disease 2 (MCKD2) and familial juvenile hyperuricaemic nephropathy (FJHN) are both autosomal dominant renal diseases characterised by juvenile onset of hyperuricaemia, gout, and progressive renal failure...
  86. doi Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression
    Kendra Sturgeon
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Development 138:65-74. 2011
    ..The homeodomain protein vHnf1 (Hnf1b) directly activates Mafb expression...
  87. ncbi A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells
    Aurélie V Poll
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Diabetes 55:61-9. 2006
    ..Among the latter, variant HNF1 (vHNF1)/TCF2, which is expressed before HNF6 in the endoderm, was found to be critical for HNF6 expression...
  88. ncbi Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage
    Cécile Haumaitre
    Unité 423 INSERM, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Biol Chem 278:40933-42. 2003
    The two members of the hepatocyte nuclear factor 1 (HNF1) transcription factor family, HNF1 and variant HNF1 (vHNF1), show a strong homology in their atypical POU-homeodomain and dimerization domain but differ in their transactivation ..
  89. pmc The Unfolded Protein Response and the Phosphorylations of Activating Transcription Factor 2 in the trans-Activation of il23a Promoter Produced by β-Glucans
    Mario Rodriguez
    From the Departamento de Bioqu mica y Biolog a Molecular, Facultad de Medicina, Universidad de Valladolid, 47005 Valladolid
    J Biol Chem 289:22942-57. 2014
    ....
  90. ncbi Uromodulin storage diseases: clinical aspects and mechanisms
    Francesco Scolari
    Divisione di Nefrologia, Spedali Civili, Brescia, Italy
    Am J Kidney Dis 44:987-99. 2004
    ..in patients with medullary cystic kidney disease type 2 (MCKD2), familial juvenile hyperuricemic nephropathy (FJHN), and glomerulocystic kidney disease (GCKD) provides the opportunity for a revision of pathogenic aspects and puts ..
  91. pmc Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
    Hui Shen
    USC Epigenome Center, Keck School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, California 90033, USA
    Nat Commun 4:1628. 2013
    b>HNF1B is overexpressed in clear cell epithelial ovarian cancer, and we observed epigenetic silencing in serous epithelial ovarian cancer, leading us to hypothesize that variation in this gene differentially associates with epithelial ..
  92. pmc Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium
    Mitchell J Machiela
    Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 176:1121-9. 2012
    ..Ten T2D markers near 9 loci (NOTCH2, ADCY5, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, MTNR1B, FTO, and HNF1B) were nominally associated with PCa (P < 0...
  93. ncbi Alterations of uromodulin biology: a common denominator of the genetically heterogeneous FJHN/MCKD syndrome
    P Vylet'al
    Center for Applied Genomics, Charles University 1st School of Medicine, Prague, Czech Republic
    Kidney Int 70:1155-69. 2006
    ..Uromodulin-associated kidney diseases' may be thus a more appropriate term for this syndrome...
  94. ncbi Expression of activating transcription factor 2 in inflammatory macrophages in obese adipose tissue
    Yugo Miyata
    Obesity (Silver Spring) . 2012
    ..These results suggest that ATF2 is an important transcriptional factor relating to inflammation through the suppression of ATF3 in M1 macrophages of WAT...
  95. pmc Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity
    Chih Chao Hsu
    Department of Medicinal Chemistry and Molecular Pharmacology and the Purdue University Center for Cancer Research, Purdue University, West Lafayette, Indiana 47907, USA
    J Biol Chem 287:8621-32. 2012
    ....
  96. doi The role of pancreatic imaging in monogenic diabetes mellitus
    Ingfrid S Haldorsen
    Department of Radiology, Haukeland University Hospital, N 5021 Bergen, Norway
    Nat Rev Endocrinol 8:148-59. 2012
    In neonatal diabetes mellitus resulting from mutations in EIF2AK3, PTF1A, HNF1B, PDX1 or RFX6, pancreatic aplasia or hypoplasia is typical...
  97. doi Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor
    Tomohiko Sase
    Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Int J Cancer 131:2284-93. 2012
    ....
  98. pmc hnf1b genes in zebrafish hindbrain development
    Seong Kyu Choe
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605 2324, USA
    Zebrafish 5:179-87. 2008
    The Hnf1b transcription factor acts during formation of rhombomeres (r) 5 and 6 in the hindbrain. To determine if hnf1b is absolutely required in r5/r6, we examined the hnf1b(hi2169) and hnf1b(hi1843) retroviral insertion alleles...
  99. doi Hepatocyte nuclear factor 1alpha and beta control terminal differentiation and cell fate commitment in the gut epithelium
    Anna D'Angelo
    Expression Génique, Développement et Maladies Equipe 26 INSERM U567 CNRS UMR 8104 Université Paris Descartes Institut Cochin Dpt Génétique et Développement, 75014 Paris, France
    Development 137:1573-82. 2010
    ..With the use of a conditional inactivation system, we generated mice in which Hnf1b is specifically inactivated in the intestinal epithelium on a wild-type or Hnf1a(-/-) genetic background...
  100. ncbi A set of polyclonal and monoclonal antibodies reveals major differences in post-translational modification of the rat HNF1 and vHNF1 homeoproteins
    T Chouard
    URA 1644 du CNRS, Departement des Biotechnologies, Paris, France
    Biochimie 79:707-15. 1997
    The related homeodomain-containing transcription factors HNF1 (HNF1 alpha) and vHNF1 (HNF1 beta) recognise common target DNA sequences in the regulatory regions of many genes and are expressed in several parenchymal cell types, ..
  101. ncbi vHnf1 regulates specification of caudal rhombomere identity in the chick hindbrain
    Ferran Aragon
    Developmental Biology Group, Departament de Ciencies Experimentals i de la Salut, Universitat Pompeu Fabra, Barcelona, Spain
    Dev Dyn 234:567-76. 2005
    The homeobox-containing gene variant hepatocyte nuclear factor-1 (vHnf1) has recently been shown to be involved in zebrafish caudal hindbrain specification, notably in the activation of MafB and Kro x 20 expression...

Research Grants80

  1. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..abstract_text> ..
  2. Molecular Mechanism of Arterial Stiffening
    Zhongjie Sun; Fiscal Year: 2010
    ..Completion of the project may offer a new therapeutic approach for large artery stiffening and related cardiovascular disorders. The finding will benefit the US population which has a high prevalence of cardiovascular disease. ..
  3. Molecular Mechanism of Arterial Stiffening
    Zhongjie Sun; Fiscal Year: 2013
    ..Completion of the project may offer a new therapeutic approach for large artery stiffening and related cardiovascular disorders. The finding will benefit the US population which has a high prevalence of cardiovascular disease. ..
  4. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2011
    ..Data obtained will yield useful information for a better understanding of corneal diseases at molecular and cellular levels in vivo and serve as basis for designing treatment regiments for corneal wound healing. ..
  5. Nell-1, A Cbfa 1 Downstream Target, In Bone Formation
    Kang Ting; Fiscal Year: 2009
    ..A better understanding of how and why Nell-1 works to form bone can accelerate the development of clinical therapies to help patients grow better and faster bone. ..
  6. Molecular Analysis of Hindbrain Development
    CHARLES G SAGERSTROM; Fiscal Year: 2010
    ..g. hoxb1a) and r5/r6 (e.g. val, vhnf1), but it is unclear how these genes act and it is likely that additional hoxb1b target genes exist...
  7. Novel Mechanism of PTH Effects on Bone Metabolism
    Bin Wang; Fiscal Year: 2013
    ....
  8. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013
    ..These experiments will yield useful information for restoration of normal vision by intervening TBR2 and ATF2 signaling pathways of injured corneas. ..
  9. Regionalization of the Vertebrate Endoderm
    Victoria E Prince; Fiscal Year: 2013
    ..the roles of two additional candidate RA-targets previously implicated in early pancreas development: the Hb9 and Tcf2 transcription factors...
  10. Hhex-a Homeobox Gene Necessary for Liver Development
    Clifford W Bogue; Fiscal Year: 2010
    ..Furthermore, we showed that deletion of Hhex is associated with decreased expression of Hnf4a, Hnf1b (TCF2) and Onecut1 (Hnf6), suggesting that Hhex regulates, either directly or indirectly, the expression of these ..
  11. Regulation of the P.aeruginosa Type III Secretion System by the Multifaceted Tran
    Florian David Schubot; Fiscal Year: 2013
    ..Lastly, we will determine the crystal structure of the regulatory domain of ExsA. This will be the first structure reported for this type of domain and may offer intriguing new insights into its functiona role. ..
  12. Mechanisms of Bile Duct Morphogenesis
    Ben Z Stanger; Fiscal Year: 2010
    ..g. hnf1b, hnf6, tgfb)...
  13. Mechanisms of Bile Duct Morphogenesis
    Ben Z Stanger; Fiscal Year: 2013
    ..g. hnf1b, hnf6, tgfb)...
  14. Roles of Growth Factors on Corneal Morphogenesis
    WINSTON KAO; Fiscal Year: 2009
    ..Data obtained will yield useful information for a better understanding of corneal diseases at molecular and cellular levels in vivo and serve as basis for designing treatment regiments for corneal wound healing. ..
  15. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2010
    ..Data obtained will yield useful information for a better understanding of corneal diseases at molecular and cellular levels in vivo and serve as basis for designing treatment regiments for corneal wound healing. ..
  16. REGULATION AND FUNCTION OF HEAT SHOCK FACTORS IN TESTIS
    KEVIN SARGE; Fiscal Year: 1999
    ..This information will provide a framework for exploring disease processes which affect spermatogenesis, and for development of new male contraceptives. ..
  17. Control of Skeletal Growth by ATF-2
    Phyllis Luvalle; Fiscal Year: 2007
    ..abstract_text> ..
  18. Control of Skeletal Growth by ATF-2
    Phyllis Luvalle; Fiscal Year: 2005
    ..abstract_text> ..
  19. Control of Skeletal Growth by ATF-2
    Phyllis Luvalle; Fiscal Year: 2006
    ..abstract_text> ..
  20. Regionalization of the Vertebrate Endoderm
    Victoria Prince; Fiscal Year: 2009
    ..the roles of two additional candidate RA-targets previously implicated in early pancreas development: the Hb9 and Tcf2 transcription factors...
  21. Regionalization of the Vertebrate Endoderm
    Victoria E Prince; Fiscal Year: 2010
    ..the roles of two additional candidate RA-targets previously implicated in early pancreas development: the Hb9 and Tcf2 transcription factors...
  22. Hhex-a Homeobox Gene Necessary for Liver Development
    CLIFFORD BOGUE; Fiscal Year: 2009
    ..Furthermore, we showed that deletion of Hhex is associated with decreased expression of Hnf4a, Hnf1b (TCF2) and Onecut1 (Hnf6), suggesting that Hhex regulates, either directly or indirectly, the expression of these ..
  23. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2004
    ..Successful completion of the experiments described in the Specific Aims will provide the basis for developing effective drug or gene therapy protocols for Sickle cell disease and Cooley's anemia. ..
  24. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2003
    ..Successful completion of the experiments described in the Specific Aims will provide the basis for developing effective drug or gene therapy protocols for Sickle cell disease and Cooley's anemia. ..
  25. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2003
    ..Successful completion of the experiments described in the Specific Aims will provide the basis for developing effective drug or gene therapy protocols for Sickle cell disease and Cooley's anemia. ..
  26. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2002
    ..Successful completion of the experiments described in the Specific Aims will provide the basis for developing effective drug or gene therapy protocols for Sickle cell disease and Cooley's anemia. ..
  27. Mechanisms For p38 MAP Kinase Dependent Gene Induction
    Betty Pace; Fiscal Year: 2001
    ..Successful completion of the experiments described in the Specific Aims will provide the basis for developing effective drug or gene therapy protocols for Sickle cell disease and Cooley's anemia. ..
  28. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2002
    ..Successful completion of the experiments described in the Specific Aims will provide the basis for developing effective drug or gene therapy protocols for Sickle cell disease and Cooley's anemia. ..
  29. Mechanisms For p38 MAP Kinase DependentT Gene Induction
    Betty Pace; Fiscal Year: 2002
    ..Successful completion of the experiments described in the Specific Aims will provide the basis for developing effective drug or gene therapy protocols for Sickle cell disease and Cooley's anemia. ..
  30. Control of Skeletal Growth by ATF-2
    Phyllis Luvalle; Fiscal Year: 2004
    ..abstract_text> ..
  31. Heat shock proteins and alcohol induced liver injury
    Pranoti Mandrekar; Fiscal Year: 2005
    ....
  32. Heat shock proteins and alcohol induced liver injury
    Pranoti Mandrekar; Fiscal Year: 2006
    ....
  33. Heat shock proteins and alcohol induced liver injury
    Pranoti Mandrekar; Fiscal Year: 2004
    ....
  34. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 2010
    ..Humans with mutations of HNF-13 develop maturity-onset diabetes of the young type 5 (MODY5) and congenital cystic abnormalities of the kidney...
  35. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 2010
    ..Humans with mutations of HNF-13 develop maturity-onset diabetes of the young type 5 (MODY5) and congenital cystic abnormalities of the kidney...
  36. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 2007
    ..Humans with mutations of HNF-13 develop maturity-onset diabetes of the young type 5 (MODY5) and congenital cystic abnormalities of the kidney...
  37. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 2009
    ..Humans with mutations of HNF-13 develop maturity-onset diabetes of the young type 5 (MODY5) and congenital cystic abnormalities of the kidney...
  38. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 2006
    ..Humans with mutations of HNF-13 develop maturity-onset diabetes of the young type 5 (MODY5) and congenital cystic abnormalities of the kidney...
  39. Variant detection and variant analysis process for diagnosis of CH and MODY
    David Margulies; Fiscal Year: 2006
    ..is of particular concern for the diagnosis of diseases commonly associated with large deletions in a gene, such as MODY5 (Bellanne-Chantelot, 2005)...
  40. Molecular Analysis of Hindbrain Development
    CHARLES SAGERSTROM; Fiscal Year: 2009
    ..g. hoxb1a) and r5/r6 (e.g. val, vhnf1), but it is unclear how these genes act and it is likely that additional hoxb1b target genes exist...
  41. Exercise-Induced Mitochondrial Biogenesis
    Zhen Yan; Fiscal Year: 2005
    ..will not only provide information to guide the correct and efficient use of regular exercise training for preventing and treating the diseases, but also facilitate discovery of new therapeutic drugs to combat the diseases ..
  42. Exercise-Induced Mitochondrial Biogenesis
    Zhen Yan; Fiscal Year: 2006
    ..will not only provide information to guide the correct and efficient use of regular exercise training for preventing and treating the diseases, but also facilitate discovery of new therapeutic drugs to combat the diseases ..
  43. Exercise-Induced Mitochondrial Biogenesis
    Zhen Yan; Fiscal Year: 2007
    ..will not only provide information to guide the correct and efficient use of regular exercise training for preventing and treating the diseases, but also facilitate discovery of new therapeutic drugs to combat the diseases ..
  44. FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKER
    Heidi Stuhlmann; Fiscal Year: 2003
    ..These include congenital cardiovascular abnormalities and pathological conditions such as rheumatoid arthritis, retinopathies, hemangiomas, psoriasis, solid tumors and metastases. ..
  45. FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKER
    Heidi Stuhlmann; Fiscal Year: 2002
    ..These include congenital cardiovascular abnormalities and pathological conditions such as rheumatoid arthritis, retinopathies, hemangiomas, psoriasis, solid tumors and metastases. ..
  46. FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKER
    Heidi Stuhlmann; Fiscal Year: 2002
    ..These include congenital cardiovascular abnormalities and pathological conditions such as rheumatoid arthritis, retinopathies, hemangiomas, psoriasis, solid tumors and metastases. ..
  47. CENTRAL CONTROL OF MOTONEURONS
    JOSEPH FETCHO; Fiscal Year: 2004
    ..The work is basic research in the neuronal control of movements. The establishment of the principles underlying the normal production of movements provides a foundation for understanding the disruptions that occur in disease states. ..
  48. Specification and Positioning of the Pancreas
    CHARLES SAGERSTROM; Fiscal Year: 2004
    ..k.a Hnfl1beta), which is mutated in MODY5 and has recently been implicated in early pancreas development, binds Meis3 and Pbx4 and we will therefore explore ..
  49. CENTRAL CONTROL OF MOTONEURONS
    JOSEPH FETCHO; Fiscal Year: 2003
    ..The work is basic research in the neuronal control of movements. The establishment of the principles underlying the normal production of movements provides a foundation for understanding the disruptions that occur in disease states. ..
  50. CENTRAL CONTROL OF MOTONEURONS
    JOSEPH FETCHO; Fiscal Year: 2005
    ..The work is basic research in the neuronal control of movements. The establishment of the principles underlying the normal production of movements provides a foundation for understanding the disruptions that occur in disease states. ..
  51. CENTRAL CONTROL OF MOTONEURONS
    JOSEPH FETCHO; Fiscal Year: 2004
    ..The work is basic research in the neuronal control of movements. The establishment of the principles underlying the normal production of movements provides a foundation for understanding the disruptions that occur in disease states. ..
  52. CENTRAL CONTROL OF MOTONEURONS
    JOSEPH FETCHO; Fiscal Year: 2002
    ..The work is basic research in the neuronal control of movements. The establishment of the principles underlying the normal production of movements provides a foundation for understanding the disruptions that occur in disease states. ..
  53. Specification and Positioning of the Pancreas
    CHARLES SAGERSTROM; Fiscal Year: 2005
    ..k.a Hnfl1beta), which is mutated in MODY5 and has recently been implicated in early pancreas development, binds Meis3 and Pbx4 and we will therefore explore ..
  54. CENTRAL CONTROL OF MOTONEURONS
    JOSEPH FETCHO; Fiscal Year: 2006
    ..The work is basic research in the neuronal control of movements. The establishment of the principles underlying the normal production of movements provides a foundation for understanding the disruptions that occur in disease states. ..
  55. CENTRAL CONTROL OF MOTONEURONS
    JOSEPH FETCHO; Fiscal Year: 2007
    ..The work is basic research in the neuronal control of movements. The establishment of the principles underlying the normal production of movements provides a foundation for understanding the disruptions that occur in disease states. ..
  56. Mechanisms of Bile Duct Morphogenesis
    BEN STANGER; Fiscal Year: 2009
    ..g. hnf1b, hnf6, tgfb)...
  57. FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKER
    Heidi Stuhlmann; Fiscal Year: 2001
    ..These include congenital cardiovascular abnormalities and pathological conditions such as rheumatoid arthritis, retinopathies, hemangiomas, psoriasis, solid tumors and metastases. ..
  58. FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKER
    Heidi Stuhlmann; Fiscal Year: 2000
    ..These include congenital cardiovascular abnormalities and pathological conditions such as rheumatoid arthritis, retinopathies, hemangiomas, psoriasis, solid tumors and metastases. ..
  59. ZINC FINGER GENES AND PANCREATIC CELL GROWTH
    Raul Urrutia; Fiscal Year: 1999
    ..Furthermore, this information will be crucial as a theoretical framework for future studies on the role of zinc finger transcription factors in pancreatic development and cancer. ..
  60. ZINC FINGER GENES AND PANCREATIC CELL GROWTH
    Raul Urrutia; Fiscal Year: 2000
    ..Furthermore, this information will be crucial as a theoretical framework for future studies on the role of zinc finger transcription factors in pancreatic development and cancer. ..
  61. ZINC FINGER GENES AND PANCREATIC CELL GROWTH
    Raul Urrutia; Fiscal Year: 2001
    ..Furthermore, this information will be crucial as a theoretical framework for future studies on the role of zinc finger transcription factors in pancreatic development and cancer. ..
  62. FUNCTION OF ATF2--URE BINDING PROTEIN IN HUMAN MELANOMA
    ZE EV RONAI; Fiscal Year: 1999
    ..Cellular components that are found to be modulated in MeWo-AFT2dn cells will be further evaluated for their inherent ability to alter radiation resistance and metastatic potential. ..
  63. FUNCTION OF ATF2--URE BINDING PROTEIN IN HUMAN MELANOMA
    ZE EV RONAI; Fiscal Year: 2000
    ..Cellular components that are found to be modulated in MeWo-AFT2dn cells will be further evaluated for their inherent ability to alter radiation resistance and metastatic potential. ..
  64. Phenogenomics of human PPARgamma mutations
    Johan Auwerx; Fiscal Year: 2007
    ..abstract_text> ..
  65. Early development of the zebrafish pancreas
    Andrea Ward; Fiscal Year: 2006
    ..The second aim of my study will test whether tcf2 and hb9 are downstream targets of retinoic acid in specifying beta-cells...
  66. Phenogenomics of human PPARgamma mutations
    Johan Auwerx; Fiscal Year: 2006
    ..abstract_text> ..
  67. Immune Regulation of Cysteinyl Leukotriene Biosynthesis
    Bing Lam; Fiscal Year: 2007
    ....
  68. Immune Regulation of Cysteinyl Leukotriene Biosynthesis
    Bing Lam; Fiscal Year: 2009
    ....
  69. Phenogenomics of human PPARgamma mutations
    Johan Auwerx; Fiscal Year: 2005
    ..abstract_text> ..
  70. Immune Regulation of Cysteinyl Leukotriene Biosynthesis
    Bing K Lam; Fiscal Year: 2010
    ....
  71. Genome Wide Mapping of in-vivo protein: DNA interactions
    SANDRA SHARP; Fiscal Year: 2003
    ....