HNF1B

Summary

Gene Symbol: HNF1B
Description: HNF1 homeobox B
Alias: FJHN, HNF-1-beta, HNF-1B, HNF1beta, HNF2, HPC11, LF-B3, LFB3, MODY5, TCF-2, TCF2, VHNF1, HNF1 beta A, hepatocyte nuclear factor 1-beta, homeoprotein LFB3, transcription factor 2, hepatic
Species: human

Top Publications

  1. ncbi Enlarged nephrons and severe nondiabetic nephropathy in hepatocyte nuclear factor-1beta (HNF-1beta) mutation carriers
    Jørn V Sagen
    Department of Pediatrics, Center for Genetics and Molecular Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Kidney Int 64:793-800. 2003
  2. ncbi Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor
    Harry A Otun
    School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Soc Gynecol Investig 12:185-90. 2005
  3. ncbi Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41
    Katerina Hodanova
    Center for Applied Genomics, Institute for Inherited Metabolic Disorders, Charles University 1st School of Medicine, Prague, Czech Republic
    Kidney Int 68:1472-82. 2005
  4. pmc Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma
    Akira Tsuchiya
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 163:2503-12. 2003
  5. pmc Genome-wide association study identifies a common variant associated with risk of endometrial cancer
    Amanda B Spurdle
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:451-4. 2011
  6. pmc Gene expression profiling predicts clinical outcome of prostate cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Clin Invest 113:913-23. 2004
  7. doi Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation
    Li Jin
    Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Pharmacol Exp Ther 340:648-55. 2012
  8. ncbi Renal cysts and diabetes syndrome linked to mutations of the hepatocyte nuclear factor-1 beta gene: description of a new family with associated liver involvement
    Alberto Montoli
    Renal Unit, Niguarda Ca Granda Hospital, Milan, Italy
    Am J Kidney Dis 40:397-402. 2002
  9. pmc Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1
    Alexander J Michels
    Linus Pauling Institute and the Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
    Am J Physiol Cell Physiol 297:C1220-7. 2009
  10. doi Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis
    Fadi Brimo
    Department of Pathology, Johns Hopkins Hospital Medical Institutions, Baltimore, MD 21287, USA
    Hum Pathol 42:1613-9. 2011

Detail Information

Publications221 found, 100 shown here

  1. ncbi Enlarged nephrons and severe nondiabetic nephropathy in hepatocyte nuclear factor-1beta (HNF-1beta) mutation carriers
    Jørn V Sagen
    Department of Pediatrics, Center for Genetics and Molecular Medicine, University of Bergen, Haukeland University Hospital, Bergen, Norway
    Kidney Int 64:793-800. 2003
    ..lead to a syndrome with diabetes and urogenital malformations [maturity onset of diabetes of the young, type 5 (MODY5)]...
  2. ncbi Spatial and temporal expression of the myometrial mitogen-activated protein kinases p38 and ERK1/2 in the human uterus during pregnancy and labor
    Harry A Otun
    School of Surgical and Reproductive Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, United Kingdom
    J Soc Gynecol Investig 12:185-90. 2005
    ....
  3. ncbi Mapping of a new candidate locus for uromodulin-associated kidney disease (UAKD) to chromosome 1q41
    Katerina Hodanova
    Center for Applied Genomics, Institute for Inherited Metabolic Disorders, Charles University 1st School of Medicine, Prague, Czech Republic
    Kidney Int 68:1472-82. 2005
    ..and progressive renal insufficiency are features associated with familial juvenile hyperuricemic nephropathy (FJHN), medullary cystic kidney disease type 1 (MCKD1) and type 2 (MCKD2). MCKD1 has been mapped to chromosome 1q21...
  4. pmc Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1 beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma
    Akira Tsuchiya
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 163:2503-12. 2003
    ..Our results suggest that HNF-1 beta is not only an excellent CCC-specific molecular marker but also a molecular target for therapy of ovarian CCC...
  5. pmc Genome-wide association study identifies a common variant associated with risk of endometrial cancer
    Amanda B Spurdle
    Division of Genetics and Population Health, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Nat Genet 43:451-4. 2011
    ..We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796, P = 7...
  6. pmc Gene expression profiling predicts clinical outcome of prostate cancer
    Gennadi V Glinsky
    Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Clin Invest 113:913-23. 2004
    ....
  7. doi Regulation of tissue-specific expression of renal organic anion transporters by hepatocyte nuclear factor 1 α/β and DNA methylation
    Li Jin
    Laboratory of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Pharmacol Exp Ther 340:648-55. 2012
    ....
  8. ncbi Renal cysts and diabetes syndrome linked to mutations of the hepatocyte nuclear factor-1 beta gene: description of a new family with associated liver involvement
    Alberto Montoli
    Renal Unit, Niguarda Ca Granda Hospital, Milan, Italy
    Am J Kidney Dis 40:397-402. 2002
    Mutations in the hepatocyte nuclear factor (HNF)-1beta gene (TCF2) are responsible for a syndrome characterized by maturity-onset diabetes of the young, a nondiabetic renal disease, genital malformations, and liver dysfunction.
  9. pmc Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1
    Alexander J Michels
    Linus Pauling Institute and the Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon 97331, USA
    Am J Physiol Cell Physiol 297:C1220-7. 2009
    ..Together, these data suggest that HNF-1alpha and/or HNF-1beta binding is required for SVCT1 expression and may be involved in the coordinate regulation of whole body vitamin C status...
  10. doi Hepatocyte nuclear factor-1β expression in clear cell adenocarcinomas of the bladder and urethra: diagnostic utility and implications for histogenesis
    Fadi Brimo
    Department of Pathology, Johns Hopkins Hospital Medical Institutions, Baltimore, MD 21287, USA
    Hum Pathol 42:1613-9. 2011
    ....
  11. pmc Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility
    Julius Gudmundsson
    deCODE Genetics, Reykjavik, Iceland
    Nat Genet 41:1122-6. 2009
    ..3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population...
  12. ncbi Hepatocyte nuclear factor-1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF-1beta in human pancreatic development
    E L Edghill
    Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Diabet Med 23:1301-6. 2006
    ..We aimed to investigate the role of HNF-1beta mutations in neonatal diabetes and also the impact of HNF-1beta mutations on fetal growth...
  13. pmc HNF1B mutations associate with hypomagnesemia and renal magnesium wasting
    Shazia Adalat
    Nephrology Unit, Great Ormond Street Hospital NHS Trust, London WCIN 3JH, UK
    J Am Soc Nephrol 20:1123-31. 2009
    Mutations in hepatocyte nuclear factor 1B (HNF1B), which is a transcription factor expressed in tissues including renal epithelia, associate with abnormal renal development...
  14. ncbi Identification of target genes of the transcription factor HNF1beta and HNF1alpha in a human embryonic kidney cell line
    Sabine Senkel
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, D 45122 Essen, Germany
    Biochim Biophys Acta 1731:179-90. 2005
    Hepatocyte nuclear factor 1beta (HNF1beta, TCF2) is a tissue-specific transcription factor whose mutation in humans leads to renal cysts, genital malformations, pancreas atrophy and maturity onset diabetes of the young (MODY5)...
  15. doi Multiple newly identified loci associated with prostate cancer susceptibility
    Rosalind A Eeles
    The Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK
    Nat Genet 40:316-21. 2008
    ..7 x 10(-29)). We confirmed previous reports of common loci associated with prostate cancer at 8q24 and 17q. Moreover, we found that three of the newly identified loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK3...
  16. pmc Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines
    K Terasawa
    Department of Obstetrics and Gynecology, Sapporo Medical University, Sapporo 060 8543, Japan
    Br J Cancer 94:914-21. 2006
    Transcription factor 2 gene (TCF2) encodes hepatocyte nuclear factor 1beta (HNF1beta), a transcription factor associated with development and metabolism...
  17. ncbi Distinct roles of HNF1beta, HNF1alpha, and HNF4alpha in regulating pancreas development, beta-cell function and growth
    Miguel Angel Maestro
    Genomic Programming of Beta Cells Laboratory, Institut d Investigacions Biomediques August Pi i Sunyer, Endocrinology, Hospital Clinic de Barcelona, Barcelona, Spain
    Endocr Dev 12:33-45. 2007
    Mutations in the genes encoding transcriptional regulators HNF1beta (TCF2), HNF1alpha (TCF1), and HNF4alpha cause autosomal dominant diabetes (also known as maturity-onset diabetes of the young)...
  18. ncbi Severe pancreas hypoplasia and multicystic renal dysplasia in two human fetuses carrying novel HNF1beta/MODY5 mutations
    Cécile Haumaitre
    Laboratoire de Biologie du Developpement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, Paris, France
    Hum Mol Genet 15:2363-75. 2006
    Heterozygous mutations in the HNF1beta/vHNF1/TCF2 gene cause maturity-onset diabetes of the young (MODY5), associated with severe renal disease and abnormal genital tract. Here, we characterize two fetuses, a 27-week male and a 31...
  19. ncbi Hepatocyte nuclear factor-1beta gene deletions--a common cause of renal disease
    Emma L Edghill
    1Institute of Biomedical and Clinical Science, Peninsula Medical School, Exeter, UK
    Nephrol Dial Transplant 23:627-35. 2008
    ..HNF-1beta gene deletions have recently been shown to cause renal malformations and early-onset diabetes...
  20. ncbi Cell-specific involvement of HNF-1beta in alpha(1)-antitrypsin gene expression in human respiratory epithelial cells
    Chaobin Hu
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Lung Cell Mol Physiol 282:L757-65. 2002
    ..These results indicate the unique involvement of HNF-1beta in alpha(1)-AT gene expression in a cell line and primary cultures derived from human respiratory epithelium...
  21. pmc Regulation of HSulf-1 expression by variant hepatic nuclear factor 1 in ovarian cancer
    Peng Liu
    Departments of Experimental Pathology, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 69:4843-50. 2009
    ..Here, we show that variant hepatic nuclear factor 1 (vHNF1), encoded by transcription factor 2 gene (TCF2, HNF1beta), negatively regulates HSulf-1 expression in ovarian cancer...
  22. doi Multiple loci identified in a genome-wide association study of prostate cancer
    Gilles Thomas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
    Nat Genet 40:310-5. 2008
    ..the combined joint analysis, we confirmed three previously reported loci (two independent SNPs at 8q24 and one in HNF1B (formerly known as TCF2 on 17q); P < 10(-10))...
  23. ncbi Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes
    Wendy Winckler
    Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA
    Diabetes 56:685-93. 2007
    ..Specifically, we determined patterns of common sequence variation in the genes encoding Gck, Ipf1, Tcf2, and NeuroD1 (MODY2 and MODY4-MODY6, respectively), selected a comprehensive set of 107 tag single nucleotide ..
  24. ncbi Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations
    Christine Bellanne-Chantelot
    Fédération des Services de Biochimie, Laboratoire de Biologie Moleculaire, Hopital Saint Antoine, Paris, France
    Ann Intern Med 140:510-7. 2004
    Maturity-onset diabetes of the young type 5 (MODY5), a type of dominantly inherited diabetes mellitus and nephropathy, has been associated with mutations of the hepatocyte nuclear factor-1beta (HNF-1beta) gene, mostly generating ..
  25. pmc Association analysis of type 2 diabetes Loci in type 1 diabetes
    Hui Qi Qu
    Departments of Pediatrics and Human Genetics, McGill University, Montreal, Quebec, Canada
    Diabetes 57:1983-6. 2008
    To search for a possible association of type 1 diabetes with 10 validated type 2 diabetes loci, i.e., PPARG, KCNJ11, WFS1, HNF1B, IDE/HHEX, SLC30A8, CDKAL1, CDKN2A/B, IGF2BP2, and FTO/RPGRIP1L.
  26. ncbi Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY
    Y Horikawa
    Nat Genet 17:384-5. 1997
  27. ncbi HNF-1 alpha and HNF-1 beta (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
    D B Mendel
    Beckman Center for Molecular and Genetic Medicine, Howard Hughes Medical Institute, Stanford University Medical School, California 94305
    Genes Dev 5:1042-56. 1991
    ..These studies define a pair of homeo domain proteins that have the potential to interact to produce an embryologically complex pattern of gene expression...
  28. ncbi Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:977-83. 2007
    ..One of the variants is in TCF2 (HNF1beta), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5...
  29. doi Common variants in maturity-onset diabetes of the young genes and future risk of type 2 diabetes
    Johan Holmkvist
    Department of Clinical Sciences Diabetes and Endocrinology, CRC, Malmö University Hospital MAS, Lund University, Malmo, Sweden
    Diabetes 57:1738-44. 2008
    ....
  30. ncbi Expression of hepatocyte nuclear factor-1beta (HNF-1beta) in clear cell tumors and endometriosis of the ovary
    Noriko Kato
    Department of Pathology, Yamagata University School of Medicine, Yamagata, Japan
    Mod Pathol 19:83-9. 2006
    ....
  31. ncbi Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1alpha and -1beta mutations
    Ewan R Pearson
    Diabetes and Vascular Medicine, Peninsula Medical School, Exeter, UK
    Diabetes Care 27:1102-7. 2004
    ..However, physiological assessment of the HNF-1beta phenotype is limited. We aimed to test the hypothesis that the diabetes phenotype due to HNF-1beta mutations is similar to that in HNF-1alpha...
  32. pmc Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies
    Katherine S Elliott
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
    PLoS ONE 5:e10858. 2010
    Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk...
  33. ncbi The HNF1beta transcription factor has several domains involved in nephrogenesis and partially rescues Pax8/lim1-induced kidney malformations
    Guizhi Wu
    Institut fur Zellbiologie, Universitatsklinikum Essen, Germany
    Eur J Biochem 271:3715-28. 2004
    The tissue-specific transcription factors HNF1alpha and HNF1beta are closely related homeodomain proteins conserved in vertebrate evolution...
  34. ncbi Scanning for MODY5 gene mutations in Chinese early onset or multiple affected diabetes pedigrees
    C Wang
    Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai No 6 People s Hospital, Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, China
    Acta Diabetol 41:137-45. 2004
    ..of HNF-1beta gene has been reported in early onset diabetes or MODY families and this gene has been defined as MODY5 gene...
  35. pmc Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
    Rosalind A Eeles
    The Institute of Cancer Research, Sutton, Surrey, UK
    Nat Genet 41:1116-21. 2009
    ..In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33))...
  36. pmc More potent transcriptional activators or a transdominant inhibitor of the HNF1 homeoprotein family are generated by alternative RNA processing
    I Bach
    Unite des Virus Oncogenes, UA 1644 du CNRS, Departement des Biotechnologies, Institut Pasteur, Paris, France
    EMBO J 12:4229-42. 1993
    ..of cDNAs from human liver encoding several isoforms of the hepatocyte nuclear factor homeoproteins HNF1 and vHNF1 generated by the differential use of polyadenylation sites and by alternative splicing...
  37. pmc Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population
    Congrong Wang
    Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China
    Diabetes 58:1023-7. 2009
    Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis...
  38. pmc Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 40:1153-5. 2008
    We carried out a fine-mapping study in the HNF1B gene at 17q12 in two study populations and identified a second locus associated with prostate cancer risk, approximately 26 kb centromeric to the first known locus (rs4430796); these loci ..
  39. doi Transcription factor HNF1beta and novel partners affect nephrogenesis
    Karin Dudziak
    Institut für Zellbiologie Tumorforschung, Universitatsklinikum Essen, Universitat Duisburg Essen, Essen, Germany
    Kidney Int 74:210-7. 2008
    ..Because of these renal anomalies, HNF1beta is classified as a CAKUT (congenital anomalies of the kidney and urinary tract) gene...
  40. ncbi Hypomethylation of hepatocyte nuclear factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary
    Noriko Kato
    Department of Pathology, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, Japan
    Virchows Arch 452:175-80. 2008
    ..These results strongly suggest that hypomethylation of the HNF-1beta CpG island participates in the HNF-1beta up-regulation in ovarian CCC...
  41. ncbi Abnormal nephron development associated with a frameshift mutation in the transcription factor hepatocyte nuclear factor-1 beta
    C Bingham
    Department of Vascular Medicine and Diabetes Research, School of Postgraduate Medicine and Health Sciences, University of Exeter, England, United Kingdom
    Kidney Int 57:898-907. 2000
    ..HNF-1 beta gene mutations are associated with a unique disorder characterized by maturity-onset diabetes of the young (MODY) and early-onset and progressive nondiabetic renal dysfunction, which may lead to chronic renal failure...
  42. ncbi pp60(v-src) induction of cyclin D1 requires collaborative interactions between the extracellular signal-regulated kinase, p38, and Jun kinase pathways. A role for cAMP response element-binding protein and activating transcription factor-2 in pp60(v-src) s
    R J Lee
    Departments of Developmental and Molecular Biology and Medicine, Albert Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 274:7341-50. 1999
    ..Induction of cyclin D1 activity by pp60(v-src) may contribute to breast tumorigenesis through phosphorylation and inactivation of the retinoblastoma protein...
  43. ncbi Evolutionary significance of intra-genome duplications on human chromosomes
    T Endo
    Center for Information Biology, National Institute of Genetics, Mishima, Shizuoka, Japan
    Gene 205:19-27. 1997
    ..We also propose that a comparative mapping of paralogous genes within the human genome would be useful for identifying new genes...
  44. ncbi p38 MAPK-mediated transcriptional activation of inducible nitric-oxide synthase in glial cells. Roles of nuclear factors, nuclear factor kappa B, cAMP response element-binding protein, CCAAT/enhancer-binding protein-beta, and activating transcription fact
    Narayan R Bhat
    Department of Neurology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 277:29584-92. 2002
    ....
  45. ncbi [Effects of Qishe Pill on vertebral hyperostosis induced by upright posture in rats]
    Qin Bian
    Institute of Spine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    Zhong Xi Yi Jie He Xue Bao 8:173-80. 2010
    ..To observe the effects of Qishe Pill, a compound traditional Chinese herbal medicine, on lumbar vertebral bone formation induced by long-time upright posture in rats and to investigate the potential mechanism...
  46. ncbi High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells
    Tusty Jiuan Hsieh
    Université de Montréal Centre hospitalier de l Université de Montréal Hôtel Dieu, Centre de Recherche Pavillon Masson, Montreal, Quebec, Canada H2W 1T8
    Endocrinology 144:4338-49. 2003
    ..Our studies demonstrate that the stimulatory effect of high glucose on ANG gene expression and IRPTC hypertrophy may be mediated at least in part via activation of hexosamine biosynthesis pathway signaling...
  47. ncbi Changes in expression of p38 mitogen-activated protein kinase in the dorsal motor nucleus of the vagus nerve and hypoglossal nucleus after axotomy in adult rats
    Tatsuo Shimokawara
    Department of Pathology, Nara Medical University, Kashihara, Japan
    Neuropathology 22:261-8. 2002
    ..Moreover, perineuronal microglial cells showed strong expression of p38 MAP kinase, active and inactive, after axotomy in both nuclei. These findings suggest that p38 MAP kinase is related to microglial cell reactions after axotomy...
  48. ncbi Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer
    R Hara
    Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 274:24779-86. 1999
    ....
  49. ncbi Towards the identification of (a) gene(s) for autosomal dominant medullary cystic kidney disease
    Francesco Scolari
    Division and Chair of Nephrology, Spedali Civili, Brescia, Italy
    J Nephrol 16:321-8. 2003
    ..The gene for familial juvenile hyperuricemic nephropathy (FJHN), a phenotype that is very similar to MCKD, was recently mapped to 16p12, in a region overlapping with the MCKD2 ..
  50. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
    ..This study shows that a general transcription factor, TFIIA gamma, facilitates osteoblast-specific gene expression through interactions with two important bone transcription factors ATF4 and Runx2...
  51. ncbi The osteoinductive properties of Nell-1 in a rat spinal fusion model
    Steven S Lu
    Dental and Craniofacial Research Institutes, UCLA School of Dentistry, Los Angeles, CA 90095, USA
    Spine J 7:50-60. 2007
    ..Previous studies showed that Nell-1 accelerates osteogenic differentiation in vitro and calvarial bone formation in vivo. We hypothesize that Nell-1 may also effectively form bone in spinal fusion...
  52. doi Role of JNK/ATF-2 pathway in inhibition of thrombospondin-1 (TSP-1) expression and apoptosis mediated by doxorubicin and camptothecin in FTC-133 cells
    Hassan El Btaouri
    Laboratoire SiRMa Signalisation Cellulaire et Récepteurs Matriciels, UMR CNRS 6237, UFR Sciences, Reims, France
    Biochim Biophys Acta 1813:695-703. 2011
    ..This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  53. pmc Differential expression of activating transcription factor-2 and c-Jun in the immature and adult rat hippocampus following lithium-pilocarpine induced status epilepticus
    Si Ryung Han
    Department of Neurology, The Catholic University of Korea, Seoul, Korea
    Yonsei Med J 50:200-5. 2009
    ..Therefore, we investigated the expression of c-Jun and ATF-2 protein in the immature and adult rat hippocampus to understand their roles in LPSE-induced neuronal death...
  54. doi Response of human alveolar bone-derived cells to a novel poly(vinylidene fluoride-trifluoroethylene)/barium titanate membrane
    L N Teixeira
    Department of Morphology, Stomatology and Physiology, School of Dentistry of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil
    J Mater Sci Mater Med 22:151-8. 2011
    ..Further in vivo experiments should be carried out to confirm the capacity of P(VDF-TrFE)/BT membrane in promoting bone formation in guided bone regeneration...
  55. ncbi Modification of DNA topoisomerase II activity via direct interactions with the cyclic adenosine-3',5'-monophosphate response element-binding protein and related transcription factors
    D J Kroll
    Division of Medical Oncology, University of Colorado Health Sciences Center, Denver 80262
    Mol Endocrinol 7:305-18. 1993
    ....
  56. pmc Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation
    Junzo Hisatsune
    Department of Bacteriology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    J Immunol 180:5017-27. 2008
    ..Thus, in U937 cells, VacA directly increases IL-8 production by activation of the p38 MAPK via intracellular Ca(2+) release, leading to activation of the transcription factors, ATF-2, CREB, and NF-kappaB...
  57. ncbi The Uromodulin C744G mutation causes MCKD2 and FJHN in children and adults and may be due to a possible founder effect
    M T F Wolf
    Department of Pediatric Nephrology of the University Children s Hospital, University of Cologne, Cologne, Germany
    Kidney Int 71:574-81. 2007
    ..in the Uromodulin (UMOD) gene were published in patients with familial juvenile hyperuricemic nephropathy (FJHN) and MCKD2. Clinical data and blood samples of 16 affected individuals from 11 different kindreds were collected...
  58. doi Role of nutritional zinc in the prevention of osteoporosis
    Masayoshi Yamaguchi
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322 0001, USA
    Mol Cell Biochem 338:241-54. 2010
    ..Zinc compounds may be designed as new supplementation factor in the prevention and therapy of osteoporosis...
  59. pmc Polyamines regulate the stability of activating transcription factor-2 mRNA through RNA-binding protein HuR in intestinal epithelial cells
    Lan Xiao
    Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Biol Cell 18:4579-90. 2007
    ..These results indicate that polyamines modulate the stability of ATF-2 mRNA by altering cytoplasmic HuR levels and that polyamine-modulated ATF-2 expression plays a critical role in regulating epithelial apoptosis...
  60. ncbi Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain
    S Brecht
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105, Kiel, Germany
    Neuroscience 120:1037-48. 2003
    ..However, changes of FKBP enzymatic activity result in suppression of the stress cell body response in the peri-infarct area as observed by suppression of c-Jun phosphorylation and Fas-L expression...
  61. ncbi p38MAPK acts in the BMP7-dependent stimulatory pathway during epithelial cell morphogenesis and is regulated by Smad1
    Ming Chang Hu
    Division of Nephrology, Program in Developmental Biology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 279:12051-9. 2004
    ..We conclude that BMP7 stimulates renal epithelial cell morphogenesis via p38(MAPK) and that p38(MAPK) activity is negatively regulated by Smad1...
  62. ncbi Suppression of C/EBPalpha expression in periportal hepatoblasts may stimulate biliary cell differentiation through increased Hnf6 and Hnf1b expression
    Harufumi Yamasaki
    Department of Biology, Faculty of Science, Shizuoka University, 836 Oya, Surugaku, Shizuoka City, Shizuoka 422 8529, Japan
    Development 133:4233-43. 2006
    ..biliary cell differentiation and gene expression of the regulatory genes for that differentiation, including Hnf1b and Hnf6...
  63. ncbi Localization of a gene for familial juvenile hyperuricemic nephropathy causing underexcretion-type gout to 16p12 by genome-wide linkage analysis of a large family
    N Kamatani
    Institute of Rheumatology, Tokyo Women s Medical University, Japan
    Arthritis Rheum 43:925-9. 2000
    Familial juvenile hyperuricemic nephropathy (FJHN, MIM 162000) is an autosomal-dominant disease characterized by underexcretion-type hyperuricemia, gout, and chronic renal failure...
  64. ncbi Familial nephropathy associated with hyperuricemia in Spain: our experience with 3 families harbouring a UMOD mutation
    J G Puig
    Division of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain
    Nucleosides Nucleotides Nucleic Acids 25:1295-300. 2006
    Since 1993 we have studied 5 Spanish families with familial nephropathy associated with hyperuricemia (FJHN). Among these families, 24 patients have been identified...
  65. ncbi Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6
    Randolph P Matthews
    Division of Gastroenterology and Nutrition, The Children s Hospital of Philadelphia and Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Development 132:5295-306. 2005
    ..with this, reduced vps33b expression was evident in hnf6-deficient larvae and in larvae with mutation of vhnf1, a downstream target of hnf6...
  66. ncbi Activating transcription factor 2 controls Bcl-2 promoter activity in growth plate chondrocytes
    Qin Ma
    Department of Anatomy and Cell Biology, College of Medicine, University of Florida, Gainesville, FL 32610 0235, USA
    J Cell Biochem 101:477-87. 2007
    ..These data identify the Bcl-2 gene as a novel target of ATF-2 and CREB in growth plate chondrocytes...
  67. pmc JunD and JunB integrate prostaglandin E2 activation of breast cancer-associated proximal aromatase promoters
    Dong Chen
    Division of Reproductive Biology Research, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Mol Endocrinol 25:767-75. 2011
    ..3/II via CRE(-211/-199). JunB also activates aromatase promoters I.3/II by maintaining JunD expression. Targeting JunD may abolish aromatase expression selectively in breast cancer tissue...
  68. ncbi The activation of c-Jun NH2-terminal kinase (JNK) by DNA-damaging agents serves to promote drug resistance via activating transcription factor 2 (ATF2)-dependent enhanced DNA repair
    Jun Hayakawa
    Department of Cancer Gene Therapy, Sidney Kimmel Cancer Center, San Diego, California 92121, USA
    J Biol Chem 278:20582-92. 2003
    ..JNK may be a rational target for sensitizing tumor cells to DNA-damaging chemotherapy agents...
  69. doi Prognostic significance of pre B cell leukemia transcription factor 2 (PBX2) expression in non-small cell lung carcinoma
    Ying Qiu
    Department of Pathology, Tongji University School of Medicine, Shanghai 200092, China
    Cancer Sci 100:1198-209. 2009
    ..PBX2 is a transcription factor for VCP in NSCLC. Because high levels of PBX2 expression correlated with prognosis of NSCLC, PBX2 could be a target molecule for treatment of NSCLC...
  70. ncbi High glucose alters the expression of genes involved in proliferation and cell-fate specification of embryonic neural stem cells
    J Fu
    Molecular Neurobiology Laboratory, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Diabetologia 49:1027-38. 2006
    ....
  71. ncbi Cbfbeta interacts with Runx2 and has a critical role in bone development
    Mondira Kundu
    Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A26, Bethesda, Maryland 20892, USA
    Nat Genet 32:639-44. 2002
    ..Our findings raise the possibility that mutations in CBFB may be responsible for some cases of cleidocranial dysplasia that are not linked to mutations in RUNX2...
  72. doi vHNF1 functions in distinct regulatory circuits to control ureteric bud branching and early nephrogenesis
    Ludmilla Lokmane
    UMR7622 CNRS Université Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Development 137:347-57. 2010
    ..Here, we identify the transcription factor vHNF1 (HNF1beta) as a crucial regulator of these early developmental events...
  73. ncbi Familial juvenile hyperuricemic nephropathy and autosomal dominant medullary cystic kidney disease type 2: two facets of the same disease?
    K Dahan
    Center for Human Genetics, Catholic University of Louvain, Brussels, Belgium
    J Am Soc Nephrol 12:2348-57. 2001
    Familial juvenile hyperuricemic nephropathy (FJHN) is an autosomal dominant disorder heralded by hyperuricemia during childhood; it is characterized by chronic interstitial nephritis, with marked thickening of tubular basement membranes, ..
  74. pmc Phosphorylation of Activation Transcription Factor-2 at Serine 121 by Protein Kinase C Controls c-Jun-mediated Activation of Transcription
    Takahito Yamasaki
    Gene Engineering Division, RIKEN BioResource Center, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074
    J Biol Chem 284:8567-81. 2009
    ..Our results suggest that the phosphorylation of ATF-2 at Ser-121 plays a key role in the c-Jun-mediated activation of transcription that occurs in response to TPA...
  75. ncbi A cluster of mutations in the UMOD gene causes familial juvenile hyperuricemic nephropathy with abnormal expression of uromodulin
    Karin Dahan
    Universite Catholique de Louvain, Center for Human Genetics, Brussels, Belgium
    J Am Soc Nephrol 14:2883-93. 2003
    Familial juvenile hyperuricemic nephropathy (FJHN [MIM 162000]) is an autosomal-dominant disorder characterized by abnormal tubular handling of urate and late development of chronic interstitial nephritis leading to progressive renal ..
  76. ncbi Runx2 deficiency in chondrocytes causes adipogenic changes in vitro
    Hirayuki Enomoto
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Cell Sci 117:417-25. 2004
    ..Our findings suggest that these Runx2-dependent functions are mediated, at least in part, by interleukin-11...
  77. pmc Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38
    Ted Kamenecka
    Department of Molecular Therapeutics and Translational Research Institute, The Scripps Research Institute, Jupiter, FL 33458, USA
    J Biol Chem 284:12853-61. 2009
    ....
  78. pmc Mutation analysis of the Uromodulin gene in 96 individuals with urinary tract anomalies (CAKUT)
    Matthias T F Wolf
    Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA
    Pediatr Nephrol 24:55-60. 2009
    ..UMOD transcription is activated by the transcription factor HNF1B. Mutations in HNF1B cause a phenotype similar to FJHN/GCKD but also congenital anomalies of the kidney and the ..
  79. doi Dissecting the nutrigenomics, diabetes, and gastrointestinal disease interface: from risk assessment to health intervention
    Lynnette R Ferguson
    The University of Auckland, Auckland, New Zealand
    OMICS 12:237-44. 2008
    ..rectifying channel, subfamily J, member 11 gene; PPAR-gamma, peroxisome proliferator activated receptor-gamma; TCF2, transcription factor 2, hepatic; WFS1, Wolfram syndrome 1...
  80. ncbi Sustained increases in activating transcription factor-2 and activator protein-2 in the rat supraoptic nucleus during water deprivation
    Rick B Meeker
    Department of Neurology, University of North Carolina, Chapel Hill, 27599, USA
    Neuroendocrinology 76:111-20. 2002
    ....
  81. ncbi Monogenic diabetes mellitus in youth. The MODY syndromes
    W E Winter
    Department of Pathology, Immunology, University of Florida College of Medicine, Gainesville, USA
    Endocrinol Metab Clin North Am 28:765-85. 1999
    ..HNF-1 alpha, MODY3), insulin promoter factor-1 (IPF-1, MODY4), and hepatocyte nuclear factor-1 beta (HNF-1 beta, MODY5)...
  82. doi Astrocytes and oligodendrocytes can be generated from NG2+ progenitors after acute brain injury: intracellular localization of oligodendrocyte transcription factor 2 is associated with their fate choice
    Jing Wei Zhao
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, UK
    Eur J Neurosci 29:1853-69. 2009
    ..We also observed Olig2(TL)GFAP(+) cells that appeared after injury and before the NG2(+)GFAP(+) phenotype. This suggests that not all astrocytes are derived from an NG2(+) population...
  83. ncbi Early growth response factor-1 mediates prostaglandin E2-dependent transcriptional suppression of cytokine-induced tumor necrosis factor-alpha gene expression in human macrophages and rheumatoid arthritis-affected synovial fibroblasts
    Wissam H Faour
    Department of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 280:9536-46. 2005
    ..We suggest that egr-1 is an immediate-early PGE2 target gene that may be a key regulatory factor in mediating eicosanoid control of genes involved in the immune and inflammatory responses...
  84. ncbi Association of activating transcription factor 2 (ATF2) with the ubiquitin-conjugating enzyme hUBC9. Implication of the ubiquitin/proteasome pathway in regulation of ATF2 in T cells
    R Firestein
    Center for Gerontology, Allegheny University of the Health Sciences and the Division of Rheumatology, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 273:5892-902. 1998
    ..d) A proteasome inhibitor delays the down-regulation of ATF2 phophorylation after T cell activation. Taken collectively, these results implicate a role for hUBC9 and the ubiquitin/proteasome pathway in regulation of ATF2 in T cells...
  85. doi Molecular markers of early orthodontic tooth movement
    Patricia Joyce Brooks
    Orthodontic Department, Faculty of Dentistry, University of Toronto, Toronto, Canada
    Angle Orthod 79:1108-13. 2009
    ..To understand the molecular basis of early orthodontic tooth movement by looking at the expression of KI-67, runt-related transcription factor 2 (Runx2), and tumor necrosis factor ligand superfamily member 11 (RANKL) proteins...
  86. ncbi Insulin-regulated gene expression
    R M O'Brien
    Department of Molecular Physiology and Biophysics, 761 MRB II, Vanderbilt University Medical School, Nashville, TN 37232, USA
    Biochem Soc Trans 29:552-8. 2001
    ..In addition, in the G6Pase catalytic subunit promoter, hepatocyte nuclear factor 1 ('HNF-1'), acts as an accessory factor to enhance the effect of insulin mediated through the IRS...
  87. pmc Lack of TCF2/vHNF1 in mice leads to pancreas agenesis
    C Haumaitre
    Biologie du Développement, Unité Mixte de Recherche 7622, Centre National de la Recherche Scientifique, Universite Pierre et Marie Curie, 9 quai St Bernard Bat C, 75005 Paris, France
    Proc Natl Acad Sci U S A 102:1490-5. 2005
    Heterozygous mutations in the human POU-homeobox TCF2 (vHNF1, HNF1beta) gene are associated with maturity-onset diabetes of the young, type 5, and abnormal urogenital tract development...
  88. ncbi Theoretical investigation of hydrogen bonds between CO and HNF2, H2NF, and HNO
    An Yong Li
    School of Chemistry and Chemical Engineering, Southwestern University, 400715, Chongqing, P R China
    J Phys Chem A 110:10805-16. 2006
    Ab initio quantum mechanics methods were applied to investigate the hydrogen bonds between CO and HNF2, H2NF, and HNO...
  89. doi Identification of the core element responsive to runt-related transcription factor 2 in the promoter of human type X collagen gene
    Akiro Higashikawa
    Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 60:166-78. 2009
    ..Aiming at clinical application, this study was undertaken to investigate transcriptional regulation of human type X collagen by RUNX-2 in human cells...
  90. pmc Regulation and functional role of the Runt-related transcription factor-2 in pancreatic cancer
    H Kayed
    Department of General Surgery, University of Heidelberg, Heidelberg, Germany
    Br J Cancer 97:1106-15. 2007
    ..In addition, Runx2 has the potential to regulate the transcription of extracellular matrix modulators such as SPARC and MMP1, thereby influencing the tumour microenvironment...
  91. ncbi Essential role for the homeoprotein vHNF1/HNF1beta in visceral endoderm differentiation
    C Coffinier
    Unite des Virus Oncogenes, CNRS URA 1644, and Unité de Biologie du Développement, CNRS URA 1960, Institut Pasteur, F 75724 Paris Cedex 15, France
    Development 126:4785-94. 1999
    vHNF1/HNF1beta, a member of the divergent HNF1/vHNF1 homeoprotein family, is expressed in polarized epithelia of several adult organs and may participate in controlling the transcription of specific genes...
  92. ncbi Variant hepatocyte nuclear factor 1 is required for visceral endoderm specification
    E Barbacci
    U423 INSERM, Hopital Necker Enfants Malades, France U257 INSERM, ICGM, France
    Development 126:4795-805. 1999
    ..We show that variant Hepatocyte Nuclear Factor 1 (vHNF1), a homeodomain-containing transcription factor first expressed in the primitive endoderm, is required for the ..
  93. ncbi A vHNF1/TCF2-HNF6 cascade regulates the transcription factor network that controls generation of pancreatic precursor cells
    Aurélie V Poll
    Hormone and Metabolic Research Unit, Université catholique de Louvain and Institute of Cellular Pathology, Avenue Hippocrate 75 7529, B 1200 Brussels, Belgium
    Diabetes 55:61-9. 2006
    ..Among the latter, variant HNF1 (vHNF1)/TCF2, which is expressed before HNF6 in the endoderm, was found to be critical for HNF6 expression...
  94. ncbi Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1
    Anatoliy Kravets
    Department of Biochemistry and Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Biol Chem 279:19916-23. 2004
    ..We propose that increased expression of the protein can be used to alter the gene expression profile in the cell...
  95. ncbi Functions of HNF1 family members in differentiation of the visceral endoderm cell lineage
    Cécile Haumaitre
    Unité 423 INSERM, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015 Paris, France
    J Biol Chem 278:40933-42. 2003
    The two members of the hepatocyte nuclear factor 1 (HNF1) transcription factor family, HNF1 and variant HNF1 (vHNF1), show a strong homology in their atypical POU-homeodomain and dimerization domain but differ in their transactivation ..
  96. doi Cdx1 refines positional identity of the vertebrate hindbrain by directly repressing Mafb expression
    Kendra Sturgeon
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Development 138:65-74. 2011
    ..The homeodomain protein vHnf1 (Hnf1b) directly activates Mafb expression...
  97. pmc Mutations of the UMOD gene are responsible for medullary cystic kidney disease 2 and familial juvenile hyperuricaemic nephropathy
    T C Hart
    University of Pittsburgh, School of Dental Medicine, Division of Oral Biology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Med Genet 39:882-92. 2002
    Medullary cystic kidney disease 2 (MCKD2) and familial juvenile hyperuricaemic nephropathy (FJHN) are both autosomal dominant renal diseases characterised by juvenile onset of hyperuricaemia, gout, and progressive renal failure...
  98. doi The stimulation of an osteogenic response by classical monocyte activation
    Omar M Omar
    Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, SE 405 30 Goteborg, Sweden
    Biomaterials 32:8190-204. 2011
    ..The signals involve regulation of autologous BMP-2 in the hMSCs. The classical activation results in profound and prolonged osteogenic effect compared to the effect of the investigated surface properties...
  99. doi Evidence that variation in the oligodendrocyte lineage transcription factor 2 (OLIG2) gene is associated with psychosis in Alzheimer's disease
    R Sims
    Department of Psychological Medicine, Cardiff University School of Medicine, Heath Park, Cardiff CF144XN, UK
    Neurosci Lett 461:54-9. 2009
    ..Significant evidence for association of psychotic symptoms within cases was identified for two SNPs, rs762237 (allelic P=0.002, OR=1.42, corrected P=0.019) and rs2834072 (allelic P=0.004, OR=1.41, corrected P=0.05)...
  100. pmc Akt1 in osteoblasts and osteoclasts controls bone remodeling
    Naohiro Kawamura
    Department of Sensory and Motor System Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    PLoS ONE 2:e1058. 2007
    ..The molecular network found in this study will provide a basis for rational therapeutic targets for bone disorders...
  101. doi Chronological histological changes during bone regeneration on a non-crosslinked atelocollagen matrix
    Ryosuke Kagawa
    Department of Oral Pathology, Osaka University Graduate School of Dentistry, Yamadaoka, Suita, Osaka, Japan
    J Bone Miner Metab 30:638-50. 2012
    ..These findings suggest that the atelocollagen itself can support bone regeneration by promoting osteoblast differentiation and type I collagen production...

Research Grants43

  1. Novel Mechanism of PTH Effects on Bone Metabolism
    Bin Wang; Fiscal Year: 2013
    ....
  2. The PKCepsilon-regulated oncogenic and tumor suppressor roles of ATF2 in melanoma
    ERIC KIRK LAU; Fiscal Year: 2013
    ..abstract_text> ..
  3. Molecular Mechanism of Arterial Stiffening
    Zhongjie Sun; Fiscal Year: 2013
    ..Completion of the project may offer a new therapeutic approach for large artery stiffening and related cardiovascular disorders. The finding will benefit the US population which has a high prevalence of cardiovascular disease. ..
  4. Nell-1, A Cbfa 1 Downstream Target, In Bone Formation
    Kang Ting; Fiscal Year: 2009
    ..A better understanding of how and why Nell-1 works to form bone can accelerate the development of clinical therapies to help patients grow better and faster bone. ..
  5. Roles of Growth Factors on Corneal Morphogenesis
    Winston W Kao; Fiscal Year: 2013
    ..These experiments will yield useful information for restoration of normal vision by intervening TBR2 and ATF2 signaling pathways of injured corneas. ..
  6. Regionalization of the Vertebrate Endoderm
    Victoria E Prince; Fiscal Year: 2013
    ..the roles of two additional candidate RA-targets previously implicated in early pancreas development: the Hb9 and Tcf2 transcription factors...
  7. Regulation of the P.aeruginosa Type III Secretion System by the Multifaceted Tran
    Florian David Schubot; Fiscal Year: 2013
    ..Lastly, we will determine the crystal structure of the regulatory domain of ExsA. This will be the first structure reported for this type of domain and may offer intriguing new insights into its functiona role. ..
  8. Hhex-a Homeobox Gene Necessary for Liver Development
    Clifford W Bogue; Fiscal Year: 2010
    ..Furthermore, we showed that deletion of Hhex is associated with decreased expression of Hnf4a, Hnf1b (TCF2) and Onecut1 (Hnf6), suggesting that Hhex regulates, either directly or indirectly, the expression of these ..
  9. Mechanisms of Bile Duct Morphogenesis
    Ben Z Stanger; Fiscal Year: 2013
    ..g. hnf1b, hnf6, tgfb)...
  10. REGULATION AND FUNCTION OF HEAT SHOCK FACTORS IN TESTIS
    KEVIN SARGE; Fiscal Year: 1999
    ..This information will provide a framework for exploring disease processes which affect spermatogenesis, and for development of new male contraceptives. ..
  11. Heat shock proteins and alcohol induced liver injury
    Pranoti Mandrekar; Fiscal Year: 2006
    ....
  12. Variant detection and variant analysis process for diagnosis of CH and MODY
    David Margulies; Fiscal Year: 2006
    ..is of particular concern for the diagnosis of diseases commonly associated with large deletions in a gene, such as MODY5 (Bellanne-Chantelot, 2005)...
  13. FUNCTIONAL ANALYSIS OF VEFZ1, A NOVEL ENDOTHELIAL MARKER
    Heidi Stuhlmann; Fiscal Year: 2003
    ..These include congenital cardiovascular abnormalities and pathological conditions such as rheumatoid arthritis, retinopathies, hemangiomas, psoriasis, solid tumors and metastases. ..
  14. Specification and Positioning of the Pancreas
    CHARLES SAGERSTROM; Fiscal Year: 2005
    ..k.a Hnfl1beta), which is mutated in MODY5 and has recently been implicated in early pancreas development, binds Meis3 and Pbx4 and we will therefore explore ..
  15. Early development of the zebrafish pancreas
    Andrea Ward; Fiscal Year: 2006
    ..The second aim of my study will test whether tcf2 and hb9 are downstream targets of retinoic acid in specifying beta-cells...
  16. Immune Regulation of Cysteinyl Leukotriene Biosynthesis
    Bing K Lam; Fiscal Year: 2010
    ....
  17. Genome Wide Mapping of in-vivo protein: DNA interactions
    SANDRA SHARP; Fiscal Year: 2003
    ....
  18. QTL mapping for genes regulating apoptosis capacity
    Jianfeng Xu; Fiscal Year: 2010
    ..Our proposal describes a novel and efficient approach to identify apoptosis genes that are critical in cancer susceptibility. ..
  19. Neuroinflammation in Cholesterol-Induced AD Pathogenesis
    Narayan Bhat; Fiscal Year: 2009
    ..The outcome of these studies should have implications for developing novel and effective anti- inflammatory treatments for AD. ..
  20. SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONE
    Thomas McCarthy; Fiscal Year: 2003
    ..Bone mass studies will be conducted using peripheral quantitative computer tomography, and will be correlated with basal and activated skeletal IGF-I expression. ..
  21. Interaction of PTEN and CDKN1B in Pca susceptibility
    Jianfeng Xu; Fiscal Year: 2008
    ..The results from this study are likely to significant advance our knowledge of prostate cancer risk and begin to explore the underlying biological mechanisms for any observed differences. ..
  22. Association of inflammatory genes and prostate cancer
    Jianfeng Xu; Fiscal Year: 2008
    ..Answers to these questions will significantly improve our knowledge of the role of inflammation in prostate cancer and will guide our efforts in identifying additional prostate cancer genes. ..
  23. Chemokin Regulation of Cartilage Matrix Resorption
    Lei Wei; Fiscal Year: 2008
    ..abstract_text> ..
  24. Zebrafish Heart Mutants:Physiological & Genetic Analyses
    Neil Chi; Fiscal Year: 2008
    ..These zebrafish mutants ultimately may serve as a novel gateway to gain new insight into the cellular and molecular mechanisms of human cardiac arrhythmias and heart failure. ..
  25. C1Q-INDUCED CA2+ RESPONSES IN FIBROBLAST HETEROGENEITY
    Sandra Bordin; Fiscal Year: 2002
    ..While this work focuses on periodontitis, its results should be applicable to a variety of inflammatory diseases as well as wound healing. ..
  26. TRANSCRIPTION FACTORS AND RENAL DEVELOPMENT
    Peter Igarashi; Fiscal Year: 2002
    ..Collectively, these studies should provide fundamental insights into transcriptional regulation of kidney morphogenesis and cystogenesis. ..
  27. Resveratrol and Human Melanoma
    Richard Niles; Fiscal Year: 2004
    ..Also the information derived from the metabolism and molecular mechanism studies could provide insights into improving/maximizing the biological activity of resveratrol. ..
  28. Folate Polymorphisms, Dietary Folate and Prostate Cancer
    Victoria Stevens; Fiscal Year: 2005
    ..The results of this study are expected to indicate the importance of folate for prostate cancer and whether changing folate consumption can modify the risk associated with genetic variants in the pathway for folate metabolism. ..
  29. Testicular Torsion: Mechanisms and Treatment
    Terry Turner; Fiscal Year: 2005
    ..It is likely that these investigations will be relevant to other forms of oxidative stress inducing testicular dysfunction. ..
  30. MAP KINASES IN OLIGODENDROCYTE CELL SIGNALING
    Narayan Bhat; Fiscal Year: 2005
    ..Putative MAPK-responsive elements and relevant binding activities will be determined by deletion and gel shift analyses ..
  31. TRANSCRIPTOME OF METASTATIC PROSTATE CANCER
    Gennadi Glinsky; Fiscal Year: 2005
    ..Subsequently the expression profile of these protein products will be studied in human prostate tumor samples by immunofluorescence analysis and immunohistochemistry to better correlate gene expression changes with phenotype. ..
  32. Evaluate the antiangiogenic properties of mda-7/IL-24
    Rajagopal Ramesh; Fiscal Year: 2006
    ..abstract_text> ..
  33. Mapping Prostate Cancer Susceptibility Genes at 8p22-23
    Jianfeng Xu; Fiscal Year: 2007
    ..Successful identification of prostate cancer genes will have a significant impact on understanding the etiology, prevention, diagnosis, and treatment of prostate cancer. ..
  34. Genetic and Morphologic Basis of Bat Wing Development
    KAREN SEARS; Fiscal Year: 2007
    ..In addition, understanding the normal roles of genes that also play a role in abnormal developmental events such as cancer (i.e., Ihh and BMP) will provide a knowledge base for additional healthcare-related biomedical research. ..
  35. The function of Runx1 in the ovary
    Misung Jo; Fiscal Year: 2007
    ..Such knowledge can be applied for promoting or inhibiting these critical facets of ovarian physiology, thereby allowing us to better manage fertility, infertility, and ovarian-based disorders. [unreadable] [unreadable]..
  36. THE PHYSIOLOGY OF IGFBP DEGRADING PROTEINASES IN BONE
    John Fowlkes; Fiscal Year: 2009
    ..abstract_text> ..
  37. REGULATION OF KIDNEY-SPECIFIC GENE EXPRESSION
    Peter Igarashi; Fiscal Year: 2010
    ..Humans with mutations of HNF-13 develop maturity-onset diabetes of the young type 5 (MODY5) and congenital cystic abnormalities of the kidney...
  38. Epithelial Cell Linage in the Kidney and Genitourinary Tract
    Peter Igarashi; Fiscal Year: 2007
    ....
  39. MAP KINASE REGULATION OF MICROGLIAL ACTIVATION
    Narayan Bhat; Fiscal Year: 2004
    ..The suppressive effects of the kinase inhibitors on activation-associated microglial functions; i.e., targeting of oligodendrocytes and myelin phagocytosis will be tested using in vitro models. ..
  40. RARbeta in Melanoma: Epigenetic Regulation by Nutrients
    Richard Niles; Fiscal Year: 2007
    ..Depending on results obtained, this investigation can be translated into nutritional studies with animal models of melanoma. [unreadable] [unreadable] [unreadable]..
  41. Pathogenesis of PKD in Mice Lacking Renal Cilia
    Peter Igarashi; Fiscal Year: 2008
    ....