HMGB2

Summary

Gene Symbol: HMGB2
Description: high mobility group box 2
Alias: HMG2, HMG-2, high mobility group protein 2, high mobility group protein B2, high-mobility group (nonhistone chromosomal) protein 2, high-mobility group box 2
Species: human

Top Publications

  1. pmc Enhancement of DNA flexibility in vitro and in vivo by HMGB box A proteins carrying box B residues
    Nadia T Sebastian
    Department of Chemistry, Creighton University, 2500 California Place, Omaha, Nebraska 68178, USA
    Biochemistry 48:2125-34. 2009
  2. pmc Dual binding modes for an HMG domain from human HMGB2 on DNA
    Micah McCauley
    Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115, USA
    Biophys J 89:353-64. 2005
  3. pmc HMGB binding to DNA: single and double box motifs
    Micah J McCauley
    Department of Physics, Northeastern University, Boston, MA 02115, USA
    J Mol Biol 374:993-1004. 2007
  4. ncbi The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures
    T T Paull
    Molecular Biology Institute, University of California Los Angeles 90024
    Genes Dev 7:1521-34. 1993
  5. ncbi HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter
    Michal Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    J Biol Chem 277:7157-64. 2002
  6. pmc Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes
    Coralie Pallier
    Unité de virologie, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France
    Mol Biol Cell 14:3414-26. 2003
  7. ncbi Conformational difference in HMGB1 proteins of human neutrophils and lymphocytes revealed by epitope mapping of a monoclonal antibody
    Ichiaki Ito
    Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda 278 8510
    J Biochem 136:155-62. 2004
  8. pmc HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent
    Aleksei N Kriatchko
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, 2500 California Plaza, Omaha, NE, USA
    BMC Mol Biol 9:32. 2008
  9. ncbi New high mobility group box 1 assay system
    Shingo Yamada
    Central Institute, Shino Test Corporation, Japan
    Clin Chim Acta 372:173-8. 2006
  10. ncbi Chromosomal high mobility group (HMG) proteins of the HMGB-type occurring in the moss Physcomitrella patens
    Bruno Kiilerich
    Department of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK 9000 Aalborg, Denmark
    Gene 407:86-97. 2008

Research Grants

Scientific Experts

  • Sun-Hwa Ha
  • Sarah Franklin
  • Shingo Yamada
  • E Boccardo
  • Aleksei N Kriatchko
  • Ming Zhang
  • Fani Mantzouridou
  • Thomas Merkle
  • Mohamed Guermah
  • Tanya R Da Sylva
  • G R Verheyen
  • David Schatz
  • M Stros
  • Thierry Dubois
  • Jim Jung-Ching Lin
  • James H Westwood
  • MARQUIS VAWTER
  • K Nagai
  • Rossella Tupler
  • Jim Jung Ching Lin
  • Gilbert Chu
  • Martin Lotz
  • Paul Billings
  • Martin K Lotz
  • Noboru Taniguchi
  • L James Maher
  • Masashi Suzuki
  • Klaus D Grasser
  • Marco E Bianchi
  • Christian Stemmer
  • Kiyoshi Ohyama
  • Mihai Ciubotaru
  • Nicole A Becker
  • Lorenza Ronfani
  • Micah J McCauley
  • Mark C Williams
  • Toshiya Muranaka
  • Zusen Fan
  • Alicia J Little
  • Takumi Takeuchi
  • Robert Küchler
  • Pearl A Campbell
  • Martin L Biniossek
  • Nathalie Jourdan
  • Li Li Wang
  • Dorothée Moisy
  • Codruta Ignea
  • Peng Hou
  • Silvia Moleri
  • Junji Itou
  • Chandra L Theesfeld
  • Dorthe S Pedersen
  • Yasuhiko Kawakami
  • Eran Bosis
  • William E Wixted
  • Jung Hee Kwon
  • Agata Leszczynska
  • Jingyun Zhang
  • Natalia F Krynetskaia
  • Hideyuki Yanai
  • Poonam Balani
  • Tobias Pusterla
  • M Wysocka-Kapcinska
  • Evan R Guggenheim
  • Setsuro Komiya
  • Nadia T Sebastian
  • Jean Fred Fontaine
  • Anastasia Kuzmin
  • Beatriz Caramés
  • Kosj Yamoah
  • Bruno Kiilerich
  • Frederik T Hansen
  • Mathieu Gissot
  • R Salgado
  • Vincent Marechal
  • Kyung Jin Kwak
  • Viktoriya Pastukh
  • Deirdre Corcoran
  • Xiaohong Zhang
  • Yukiko Kamide
  • Noriko Nagata
  • Eillen Tecle
  • Yi Sheng
  • Raffaella Catena
  • Veronique Ouellet
  • Francisco Meirelles Bastos de Oliveira
  • Shigeo Yoshida
  • Kazuo Masuda
  • Louis Philippe Corbeil-Girard
  • Micah McCauley

Detail Information

Publications129 found, 100 shown here

  1. pmc Enhancement of DNA flexibility in vitro and in vivo by HMGB box A proteins carrying box B residues
    Nadia T Sebastian
    Department of Chemistry, Creighton University, 2500 California Place, Omaha, Nebraska 68178, USA
    Biochemistry 48:2125-34. 2009
    ..in vitro and Escherichia coli DNA looping assays in vivo that an isolated HMG box A domain derived from human HMGB2 folds poorly and does not enhance apparent DNA flexibility...
  2. pmc Dual binding modes for an HMG domain from human HMGB2 on DNA
    Micah McCauley
    Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, Massachusetts 02115, USA
    Biophys J 89:353-64. 2005
    ..In the presence of nanomolar concentrations of isolated HMG box A from HMGB2, DNA shows a decrease in its persistence length, where the protein induces an average DNA bend angle of 114 +/- 21 ..
  3. pmc HMGB binding to DNA: single and double box motifs
    Micah J McCauley
    Department of Physics, Northeastern University, Boston, MA 02115, USA
    J Mol Biol 374:993-1004. 2007
    ..used to extend double-stranded DNA (dsDNA) in the absence as well as presence of a single box derivative of human HMGB2 [HMGB2(box A)] and a double box derivative of rat HMGB1 [HMGB1(box A+box B)]...
  4. ncbi The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures
    T T Paull
    Molecular Biology Institute, University of California Los Angeles 90024
    Genes Dev 7:1521-34. 1993
    The mammalian high mobility group proteins HMG1 and HMG2 are abundant, chromatin-associated proteins whose cellular function is not known...
  5. ncbi HMGB1 and HMGB2 cell-specifically down-regulate the p53- and p73-dependent sequence-specific transactivation from the human Bax gene promoter
    Michal Stros
    Institute of Biophysics, Academy of Sciences of the Czech Republic, Kralovopolska 135, 612 65 Brno, Czech Republic
    J Biol Chem 277:7157-64. 2002
    ..Previous reports have shown that architectural DNA-bending/looping chromosomal proteins HMGB1 and HMGB2 (formerly known as HMG1 and HMG2), which function in a number of biological processes including transcription and ..
  6. pmc Association of chromatin proteins high mobility group box (HMGB) 1 and HMGB2 with mitotic chromosomes
    Coralie Pallier
    Unité de virologie, Service de Bacteriologie Virologie, Hopital de Bicetre, Assistance Publique Hopitaux de Paris, 94275 Le Kremlin Bicetre, France
    Mol Biol Cell 14:3414-26. 2003
    ..e., free and associated with the condensed chromatin, which rapidly exchange. A detailed analysis of HMGB2 interaction with mitotic chromosomes indicated that two sites encompassing HMG-box A and B are responsible for ..
  7. ncbi Conformational difference in HMGB1 proteins of human neutrophils and lymphocytes revealed by epitope mapping of a monoclonal antibody
    Ichiaki Ito
    Department of Biological Science and Technology, Science University of Tokyo, 2641 Yamazaki, Noda 278 8510
    J Biochem 136:155-62. 2004
    HMGB1 and HMGB2 are abundant nonhistone chromosomal proteins in eukaryotic organisms. Their respective primary sequences are highly conserved...
  8. pmc HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent
    Aleksei N Kriatchko
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, 2500 California Plaza, Omaha, NE, USA
    BMC Mol Biol 9:32. 2008
    ..cleavage in vitro, these activities are stimulated by the architectural DNA binding and bending factors HMGB1 and HMGB2. Two previous studies (Bergeron et al., 2005, and Dai et al...
  9. ncbi New high mobility group box 1 assay system
    Shingo Yamada
    Central Institute, Shino Test Corporation, Japan
    Clin Chim Acta 372:173-8. 2006
    ..HMGB1 (high mobility group box 1) protein has been shown to play a critical role in several inflammatory diseases and it may be involved in the development of atherosclerosis...
  10. ncbi Chromosomal high mobility group (HMG) proteins of the HMGB-type occurring in the moss Physcomitrella patens
    Bruno Kiilerich
    Department of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK 9000 Aalborg, Denmark
    Gene 407:86-97. 2008
    ..The structurally similar HMGB2 and HMGB3 proteins display the typical overall structure of higher plant HMGB proteins consisting of a central HMG-..
  11. pmc Nucleocytoplasmic distribution of the Arabidopsis chromatin-associated HMGB2/3 and HMGB4 proteins
    Dorthe S Pedersen
    Department of Life Sciences, Aalborg University, DK 9000 Aalborg, Denmark
    Plant Physiol 154:1831-41. 2010
    ..green fluorescent protein, we have examined the subcellular localization of the Arabidopsis (Arabidopsis thaliana) HMGB2/3 and HMGB4 proteins, revealing that, in addition to a prominent nuclear localization, they can be detected also ..
  12. ncbi Molecular evolution of Sry and Sox gene
    K Nagai
    Tokyo Medical University, Department of Biochemistry, 160 8402, Tokyo, Japan
    Gene 270:161-9. 2001
    ..They diverged into two subgroups: one contains HMG14 and HMG17, and the other one contains HMG1 and HMG2 with various other genes...
  13. pmc Retroposed copies of the HMG genes: a window to genome dynamics
    Liora Z Strichman-Almashanu
    Computational Biology Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA
    Genome Res 13:800-12. 2003
    ..among the HMGs was not even, with 33-65 each for HMGB1, HMGB3, HMGN1, and HMGN2, and 0-6 each for HMGA1, HMGA2, HMGB2, and HMGN3...
  14. pmc Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathway
    Noboru Taniguchi
    Department of Arthritis Research, The Scripps Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 106:16817-22. 2009
    ..HMGB) protein 2 is restricted to the SZ in articular cartilage suggesting a transcriptional regulation involving HMGB2 in SZ...
  15. ncbi Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein Hmgb2
    L Ronfani
    DIBIT, Istituto Scientifico San Raffaele, Via Olgettina 58, Italy
    Development 128:1265-73. 2001
    High mobility group 2 protein (Hmgb2) is a member of the HMGB protein family, which includes the ubiquitous Hmgb1 and the embryo-specific Hmgb3...
  16. pmc Determinants of HMGB proteins required to promote RAG1/2-recombination signal sequence complex assembly and catalysis during V(D)J recombination
    Yan Dai
    Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Mol Cell Biol 25:4413-25. 2005
    ..are competent for V(D)J cleavage requires the presence of the nonspecific DNA binding and bending protein HMGB1 or HMGB2. We find that either of the two minimal DNA binding domains of HMGB1 is effective in assembling RAG1/2-RSS ..
  17. ncbi High mobility group B2 is secreted by myeloid cells and has mitogenic and chemoattractant activities similar to high mobility group B1
    Tobias Pusterla
    San Raffaele Scientific Institute, Via Olgettina 58, 20132, Milan, Italy
    Autoimmunity 42:308-10. 2009
    ..HMGB1 can be actively secreted by inflammatory cells. Here, we report that also HMGB2 can be secreted by THP-1 cells, and promotes proliferation and migration of endothelial cells...
  18. pmc Fluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex
    Mihai Ciubotaru
    Howard Hughes Medical Institute and Department of Immunibiology, Yale University School of Medicine, New Haven, CT 06520 8011, USA
    Mol Cell Biol 27:4745-58. 2007
    ..FRET requires an appropriate 12/23 RSS pair, a divalent metal ion, and high-mobility-group protein HMGB1 or HMGB2. Energy transfer between the RSSs was detected with all 12/23 RSS end positions of the fluorescent probes but was ..
  19. doi Expression of human papillomavirus type 16 E7 oncoprotein alters keratinocytes expression profile in response to tumor necrosis factor-alpha
    Enrique Boccardo
    Virology Group, Ludwig Institute for Cancer Research, São Paulo 01323 903, Brazil
    Carcinogenesis 31:521-31. 2010
    ..Differential expression of TCN1 (transcobalamin I), IFI44 (Interferon-induced protein 44), HMGB2 (high-mobility group box 2) and FUS [Fusion (involved in t(12;16) in malignant liposarcoma)] among other genes ..
  20. ncbi Hmg-coA reductase gene family in cotton (Gossypium hirsutum L.): unique structural features and differential expression of hmg2 potentially associated with synthesis of specific isoprenoids in developing embryos
    L L Loguercio
    Department of Agronomy and Range Science, University of California, Davis 95616, USA
    Plant Cell Physiol 40:750-61. 1999
    ..that accumulate in specialized pigment glands of cotton at the molecular level, two full-length genes (hmg1 and hmg2) were characterized encoding hmg-coA reductase (HMGR; EC 1.1.1...
  21. pmc Eukaryotic HMGB proteins as replacements for HU in E. coli repression loop formation
    Nicole A Becker
    Department of Biochemistry and Molecular Biology, Mayo Clinic College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Nucleic Acids Res 36:4009-21. 2008
    ..coli expressing normal levels of HU protein. Nhp6A-induced changes in the DNA length-dependence of repression efficiency suggest that Nhp6A alters DNA twist in vivo. In contrast, human HMGB2-box A derivatives did not rescue looping.
  22. ncbi SET complex in serous epithelial ovarian cancer
    Veronique Ouellet
    Centre de recherche du centre hospitalier de l Université de Montréal CHUM, Institut du Cancer de Montreal, Montreal, Canada
    Int J Cancer 119:2119-26. 2006
    ..In this analysis, 4 out of 5 members of the SET complex, SET, APE1, NM23 and HMGB2, were highly expressed in invasive grade 3 tumors...
  23. ncbi Access to exercise and its relation to cardiovascular health and gene expression in laboratory animals
    Natalie B Schweitzer
    Department of Zoology, Miami University, Oxford, OH 45056, USA
    Life Sci 77:2246-61. 2005
    ..Mean gene expressions for Gja1, Fdft1, Edn1, Cd36, and Hmgb2 differed in animals according to access to physical activity...
  24. ncbi [Analysis of cytogenetic abnormalities in squamous cell carcinoma by array comparative genomic hybridization]
    R Salgado
    Servicio de Anatomía Patológica Laboratorio de Citogenética y Biología Molecular Hospital del Mar Barcelona España
    Actas Dermosifiliogr 99:199-206. 2008
    ..The aim of this study was to analyze the presence of genetic abnormalities in a series of patients with SCC using the technique of array CGH...
  25. pmc Synapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination
    Mihai Ciubotaru
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar St, TAC S625, New Haven, CT 06510
    Mol Cell Biol 24:8727-44. 2004
    ..signal sequences (RSSs) by the RAG1 and RAG2 proteins, aided by a high-mobility group protein, HMG1 or HMG2. Double-strand DNA cleavage within this synaptic, or paired, complex is thought to involve DNA distortion or ..
  26. doi A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference
    William E Wixted
    Respiratory Center for Excellence in Drug Discovery, GlaxoSmithKline R and D, King of Prussia, PA 19406, USA
    Toxicol In Vitro 24:310-8. 2010
    ..g. unfolded protein response, proteosomal activity) and targets (e.g. MAP3K14, HMGB2) that regulate the response of lung epithelial cells to oxidative stress...
  27. ncbi DNA bending induced by high mobility group proteins studied by fluorescence resonance energy transfer
    M Lorenz
    Institute for Molecular Biotechnology, Jena, Germany
    Biochemistry 38:12150-8. 1999
    The HMG domains of the chromosomal high mobility group proteins homologous to the vertebrate HMG1 and HMG2 proteins preferentially recognize distorted DNA structures. DNA binding also induces a substantial bend...
  28. pmc Complete blockage of the mevalonate pathway results in male gametophyte lethality
    Masashi Suzuki
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045, Japan
    J Exp Bot 60:2055-64. 2009
    ..Previously, Arabidopsis mutants for HMG1 and HMG2 encoding HMG-CoA reductase (HMGR) were isolated...
  29. ncbi Isolation of a chicken HMG2 cDNA clone and evidence for an HMG2-specific 3'-untranslated region
    D L Davis
    Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111
    Gene 113:251-6. 1992
    HMG1 and HMG2 (high-mobility group proteins) are two of the most abundant nonhistone chromosomal proteins in higher eukaryotes...
  30. ncbi Cloning and characterization of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase in melon (Cucumis melo L. reticulatus)
    S Kato Emori
    Plant Biotechnology Institute, Ibaraki Agricultural Center, Iwama, Japan
    Mol Genet Genomics 265:135-42. 2001
    ..Database searches revealed that Cm-HMGR shows homology to HMG1 (63.7%) and HMG2 (70.3%) of tomato, to HMG1 (77.2%) and HMG2 (69.4%) of Arabidopsis thaliana, and to HMGR of tobacco (72.6%)...
  31. ncbi Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates
    Mohamed Guermah
    Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Cell 125:275-86. 2006
    ..The purification of CTEA also identified HMGB2 as a coactivator that, while inactive on its own, enhances SII and p300 functions.
  32. doi Observations on squalene accumulation in Saccharomyces cerevisiae due to the manipulation of HMG2 and ERG6
    Fani Mantzouridou
    School of Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    FEMS Yeast Res 10:699-707. 2010
    The constructed strains AM63, having an extra copy of the HMG2 gene with a K6R stabilizing mutation in Hmg2p expressed under the control of the inducible galactose promoter and stably integrated into the chromosomal HO locus, and AM64, a ..
  33. ncbi Microarray analysis of the effect of diesel exhaust particles on in vitro cultured macrophages
    Geert R Verheyen
    Centre of Expertise in Environmental Toxicology, Flemish Institute for Technological Research VITO, Boeretang 200, B 2400 Mol, Belgium
    Toxicol In Vitro 18:377-91. 2004
    ..SEC6, TNFRSF1B, LPXN, LOC51093 and BTG2) are upregulated and seven (PRDX1, CD36, PRKACB, BBOX1, CLK1, STMN1, and HMGB2) are downregulated at both time-points...
  34. ncbi Gonadotropin-regulated testicular RNA helicase (GRTH/Ddx25) is a transport protein involved in gene-specific mRNA export and protein translation during spermatogenesis
    Yi Sheng
    Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 281:35048-56. 2006
    ..GRTH selectively regulated the translation of specific genes including histone 4 and HMG2 in germ cells...
  35. ncbi Expression of a defense-related 3-hydroxy-3-methylglutaryl CoA reductase gene in response to parasitization by Orobanche spp
    J H Westwood
    Department of Plant Pathology, Physiology and Weed Science, Virginia Polytechnic Institute and State University, Blacksburg 24061 0331, USA
    Mol Plant Microbe Interact 11:530-6. 1998
    ..We have demonstrated that parasitization by Orobanche induces expression of hmg2, a defense-related isogene of 3-hydroxy-3-methylglutaryl CoA reductase (HMGR) in tobacco...
  36. ncbi Molecular characterization of three 3-hydroxy-3-methylglutaryl-CoA reductase genes including pathogen-induced Hmg2 from pepper (Capsicum annuum)
    Sun Hwa Ha
    Division of Metabolic Engineering, National Institute of Agricultural Biotechnology, RDA, 441 707, Suwon, South Korea
    Biochim Biophys Acta 1625:253-60. 2003
    ..cv. NocKwang) and the HMGR2 gene (Hmg2) was especially obtained from a cDNA library constructed with Phytophthora capsici-infected pepper root RNAs...
  37. ncbi Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis
    Kiyoshi Ohyama
    RIKEN Plant Science Center, Yokohama, Kanagawa, Japan
    Chem Pharm Bull (Tokyo) 55:1518-21. 2007
    ..We have previously isolated Arabidopsis mutants in HMG1 and HMG2. Although the biochemical function of HMGR2 has been thought to be almost equal to that of HMGR1, based on ..
  38. doi Functional expression of human HMG-CoA reductase in Saccharomyces cerevisiae: a system to analyse normal and mutated versions of the enzyme in the context of statin treatment
    M Wysocka-Kapcinska
    Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland
    J Appl Microbiol 106:895-902. 2009
    ..In this paper, we present a Saccharomyces cerevisiae expression system, which enables quick evaluation of the sensitivity of the wild-type and/or mutant forms of human HMG-CoA reductase towards statins or other drugs...
  39. ncbi Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMG1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels
    Masashi Suzuki
    Plant Science Center, RIKEN, Tsurumi ku, Yokohama, Kanagawa 230 0045, Japan
    Plant J 37:750-61. 2004
    ..To understand the contribution of HMGR to plant development, we isolated T-DNA insertion mutants for HMG1 and HMG2. The hmg1 and hmg2 mutants were both more sensitive than the wild type (WT) to lovastatin, an inhibitor of HMGR...
  40. pmc Investigating the effects of statins on cellular lipid metabolism using a yeast expression system
    Agata Leszczynska
    Institute of Biochemistry and Biophysics PAS, Polish Academy of Sciences, Warsaw, Poland
    PLoS ONE 4:e8499. 2009
    ..Using a yeast strain with deletions of both HMG1 and HMG2 genes (i.e...
  41. ncbi Temporal expression of transcripts related to embryo quality in bovine embryos cultured from the two-cell to blastocyst stage in vitro or in vivo
    Deirdre Corcoran
    School of Agriculture, Food Science and Veterinary Medicine, Conway Institute for Biomolecular and Biomedical Research, College of Life Sciences, University College Dublin, Belfield, Dublin, Ireland
    Mol Reprod Dev 74:972-7. 2007
    ..Analysis of relative transcript abundance for FOXO3A, EEF1G, HMG2, and REA was performed using quantitative real-time PCR...
  42. ncbi A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif
    A H Sinclair
    Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, Lincoln s Inn Fields, London, UK
    Nature 346:240-4. 1990
    ..pombe and a conserved DNA-binding motif present in the nuclear high-mobility-group proteins HMG1 and HMG2. This gene has been termed SRY (for sex-determining region Y) and proposed to be a candidate for the elusive testis-..
  43. ncbi PABPN1 overexpression leads to upregulation of genes encoding nuclear proteins that are sequestered in oculopharyngeal muscular dystrophy nuclear inclusions
    Louis Philippe Corbeil-Girard
    Laboratoire de Neurogénétique, Centre de Recherche du CHUM, Universite de Montreal, Montreal, Quebec, Canada H2L 4M1
    Neurobiol Dis 18:551-67. 2005
    ..nuclear proteins encoded by eight upregulated genes colocalize with PABPN1 within the INIs: CUGBP1, SFRS3, FKBP1A, HMG2, HNRPA1, PRC1, S100P, and HSP70. In addition, CUGBP1, SFRS3, and FKBP1A were also found in OPMD muscle INIs...
  44. pmc Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae
    Codruta Ignea
    Centre International de Hautes Etudes Agronomiques Méditerranéennes, Mediterranean Agronomic Institute of Chania, Chania 73100, Greece
    Microb Cell Fact 11:162. 2012
    ..Due to their industrial application, there is increasing interest in the development of S. cerevisiae strains capable of producing high levels of terpenoids...
  45. pmc High-mobility group boxes mediate cell proliferation and radiosensitivity via retinoblastoma-interaction-dependent and -independent mechanisms
    Li Li Wang
    Department of Radiotherapy, The First Affiliated Hospital of Soochow University, Suzhou, China
    Cancer Biother Radiopharm 27:329-35. 2012
    ..In this study, we have demonstrated that like HMGB1, HMGB2-3 also associated with the RB in vitro and in vivo, as evidenced by glutathione-s-transferase capture and ..
  46. pmc Live-cell imaging reveals multiple interactions between Epstein-Barr virus nuclear antigen 1 and cellular chromatin during interphase and mitosis
    Nathalie Jourdan
    UPMC Universite Paris 6, UMRS 872, Paris, France
    J Virol 86:5314-29. 2012
    ..We also performed a yeast double-hybrid screening, followed by a FRET analysis, that led us to identify HMGB2 (high-mobility group box 2), a well-known chromatin component, as a new partner for EBNA-1 on chromatin during ..
  47. doi Oct4 interaction with Hmgb2 regulates Akt signaling and pluripotency
    Pearl A Campbell
    Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
    Stem Cells 31:1107-20. 2013
    ..modifications (PTMs) form a positive feedback loop, which promotes Akt activation and interaction with Hmgb2 and the SET complex...
  48. pmc High-mobility group chromatin proteins 1 and 2 functionally interact with steroid hormone receptors to enhance their DNA binding in vitro and transcriptional activity in mammalian cells
    V Boonyaratanakornkit
    Department of Pathology and Molecular Biology Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Mol Cell Biol 18:4471-87. 1998
    ....
  49. pmc Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth
    Sarah Franklin
    Department of Anesthesiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Mol Cell Proteomics 11:M111.014258. 2012
    ..RNA-mediated loss-of-function in isolated cells, we demonstrate that the non-histone chromatin structural protein HMGB2 (but not HMGB1) suppresses pathologic cell growth in vivo and controls a gene expression program responsible for ..
  50. pmc HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication
    Dorothée Moisy
    Institut Pasteur, Unité de Génétique Moléculaire des Virus à ARN, Departement de Virologie, Paris, France
    J Virol 86:9122-33. 2012
    ..HMGB1 and HMGB2 bind directly to the purified NP in the absence of viral RNA, and the HMG box A domain is sufficient to bind the ..
  51. ncbi Gene expression profiling of a clonal isolate of oxaliplatin-resistant ovarian carcinoma cell line A2780/C10
    Rama R Varma
    Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Oncol Rep 14:925-32. 2005
    ..The mRNA levels of six differentially expressed genes (COL6A3, MMP12, MMP3, WNT5A, NID, and HMGB2) were validated using real-time quantitative RT-PCR...
  52. pmc High-resolution mapping of genomic imbalance and identification of gene expression profiles associated with differential chemotherapy response in serous epithelial ovarian cancer
    Marcus Bernardini
    Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Neoplasia 7:603-13. 2005
    ..Within this group, five genes (GAPD, HMGB2, HSC70, GRP58, and HMGB1), previously shown to form a nuclear complex associated with resistance to DNA ..
  53. pmc Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA
    Alicia J Little
    Department of Immunobiology, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06511, USA
    Nucleic Acids Res 41:3289-301. 2013
    ..sequences (RSSs), aided by the ubiquitous DNA-binding/-bending proteins high-mobility group box protein (HMGB)1 or HMGB2. HMGB1/2 play a critical, although poorly understood, role in vitro in the assembly of functional RAG-RSS ..
  54. ncbi High mobility group B proteins facilitate strong estrogen receptor binding to classical and half-site estrogen response elements and relax binding selectivity
    Dweepanita Das
    Department of Chemistry, Bowling Green State University, Overman Hall, Bowling Green, Ohio 43403, USA
    Mol Endocrinol 18:2616-32. 2004
    ..We examined the effect of the coactivator proteins, HMGB1 and HMGB2, in enhancing ER binding affinity to single and tandem EREs...
  55. doi Quantitative proteomic profiling of tumor cell response to telomere dysfunction using isotope-coded protein labeling (ICPL) reveals interaction network of candidate senescence markers
    Martin L Biniossek
    Institute of Molecular Medicine Cell Research, University of Freiburg, Freiburg, Germany
    J Proteomics 91:515-35. 2013
    ..A loss of the chromatin protein HMGB2 was demonstrated not only in various telomerase-inhibited clones of different tumor cell lines, but also in normal ..
  56. ncbi Cytosolic HMGB1 expression in human renal clear cell cancer indicates higher pathological T classifications and tumor grades
    Takumi Takeuchi
    Department of Urology, Kanto Rosai Hospital, Kawasaki, Japan
    Urol J 10:960-5. 2013
    ..Recent reports indicate that HMGB1 functions as a proinflammatory cytokine. Here, we studied expressions of HMGB1 and HMGB2 in human renal cancer.
  57. ncbi Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum
    Francisco Meirelles Bastos de Oliveira
    Instituto de Bioquimica Medica, Centro de Ciencias da Saude, Universidade Federal do Rio de Janeiro, Ilha do Fundao, Brazil
    Gene 377:33-45. 2006
    The parasitic helminth Schistosoma mansoni contains three HMGB proteins, HMGB1, HMGB2 and HMGB3, of primary amino acid sequences highly similar to vertebrate proteins...
  58. pmc Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein
    Robert Küchler
    Dr Margarete Fischer Bosch Institute for Clinical Pharmacology and University of Tübingen, Stuttgart, Germany
    Antimicrob Agents Chemother 57:4782-93. 2013
    ..based on antimicrobial function, here we identified competent antibacterial activity of high-mobility-group box 2 (HMGB2) against Escherichia coli...
  59. pmc The DNA-bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition
    Hatem Zayed
    Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, D 13092 Berlin, Germany
    Nucleic Acids Res 31:2313-22. 2003
    ..This effect was rescued by transient over-expression of HMGB1, and was partially complemented by HMGB2, but not with the HMGA1 protein...
  60. ncbi In vitro acetylation of HMGB-1 and -2 proteins by CBP: the role of the acidic tail
    Evdokia Pasheva
    Institute of Molecular Biology, Bulgarian Academy of Sciences, 1113 Sofia, Bulgaria
    Biochemistry 43:2935-40. 2004
    ..The alterations in the acetylation pattern of HMGB-1 and -2 upon removal of the C-terminal tail are regarded as a means by which the acidic domain modulates some properties of these proteins...
  61. ncbi Protein kinase CK2 differentially phosphorylates maize chromosomal high mobility group B (HMGB) proteins modulating their stability and DNA interactions
    Christian Stemmer
    Department of Life Science, Aalborg University, Sohngaardsholmsvej 49, DK 9000 Aalborg, Denmark
    J Biol Chem 277:1092-8. 2002
    ..modifications of five HMGB proteins from maize suspension cultured cells, revealing that HMGB1 and HMGB2/3, but not HMGB4 and HMGB5, are phosphorylated by protein kinase CK2...
  62. doi Overexpression of high-mobility group box 2 is associated with tumor aggressiveness and prognosis of hepatocellular carcinoma
    Jung Hee Kwon
    Department of Life Science, Pohang University of Science and Technology, Hyoja Dong, Pohang, South Korea
    Clin Cancer Res 16:5511-21. 2010
    We investigated the expression of high-mobility group box 2 (HMGB2) in patients with hepatocellular carcinoma (HCC) and its clinical effects with underlying mechanisms.
  63. doi HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 462:99-103. 2009
    ..Hmgb1(-/-) and Hmgb2(-/-) mouse cells are defective in type-I interferon and inflammatory cytokine induction by DNA or RNA targeted to ..
  64. pmc Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium
    Xiaohong Zhang
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 2:e1087. 2007
    ..also perturbs RNA polymerase II (Pol II) transcripts from genes encoding chromatin structure proteins histone 3 and HMG2, transcription factor Gli2, gap-junction protein connexin 43 and adheren E-cadherin...
  65. pmc Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA
    Evan R Guggenheim
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Chembiochem 10:141-57. 2009
    ..repair factors RPA1, Ku70, Ku80, Msh2, DNA ligase III, PARP-1, and DNA-PKcs, as well as HMG-domain proteins HMGB1, HMGB2, HMGB3, and UBF1...
  66. pmc Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage
    Natalia F Krynetskaia
    Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
    Mol Cancer Ther 8:864-72. 2009
    ..The functional role of HMGB1 and HMGB1-associated proteins (high-mobility group protein B2, HMGB2; glyceraldehyde-3-phosphate dehydrogenase, GAPDH; protein disulfide isomerase family A member 3, PDIA3; and heat ..
  67. doi A novel family of plant DNA-binding proteins containing both HMG-box and AT-rich interaction domains
    Frederik T Hansen
    Department of Life Sciences, Aalborg University, Sohngaardsholmsvej 49, DK 9000 Aalborg, Denmark
    Biochemistry 47:13207-14. 2008
    ..The genes encoding ARID-HMG1 and ARID-HMG2 are widely expressed in Arabidopsis but at different levels...
  68. pmc Mechanism of DNA flexibility enhancement by HMGB proteins
    Jingyun Zhang
    Department of Physics, Northeastern University, Boston, MA 02115, USA
    Nucleic Acids Res 37:1107-14. 2009
    ..flexibility is studied by examining complexes of double-stranded DNA with the high mobility group type B proteins HMGB2 (Box A) and HMGB1 (Box A+B) using atomic force microscopy...
  69. pmc High mobility group box2 promoter-controlled suicide gene expression enables targeted glioblastoma treatment
    Poonam Balani
    Institute of Bioengineering and Nanotechnology, Singapore
    Mol Ther 17:1003-11. 2009
    ..We observed that the human high mobility group box2 (HMGB2) gene had a low level of expression in normal human brain tissues, but was significantly upregulated in ..
  70. pmc High mobility group protein HMGB2 is a critical regulator of plasmodium oocyst development
    Mathieu Gissot
    Department of Medicine and of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 283:17030-8. 2008
    ..We disrupted the Plasmodium yoelii gene encoding high mobility group nuclear factor hmgb2, which encodes a DNA-binding protein potentially implicated in transcriptional regulation of malaria gene ..
  71. pmc HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex
    Ming Zhang
    Department of Medical Microbiology and Immunology, Creighton University Medical Center, Omaha, NE, USA
    BMC Mol Biol 10:24. 2009
    ..The high mobility group proteins HMGB1 and HMGB2 (HMGB1/2) are highly abundant architectural DNA binding proteins known to promote RAG-mediated synapsis and ..
  72. pmc HMGB factors are required for posterior digit development through integrating signaling pathway activities
    Junji Itou
    Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota, USA
    Dev Dyn 240:1151-62. 2011
    The chromatin factors Hmgb1 and Hmgb2 have critical roles in cellular processes, including transcription and DNA modification...
  73. doi The HMGB protein gene family in zebrafish: Evolution and embryonic expression patterns
    Silvia Moleri
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Milano, Italy
    Gene Expr Patterns 11:3-11. 2011
    ..In mammals, three family members are present: HMGB1, HMGB2 and HMGB3...
  74. pmc The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2
    Chandra L Theesfeld
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA
    J Biol Chem 286:26298-307. 2011
    ..The yeast HMG-CoA reductase isozyme Hmg2, like its mammalian counterpart, undergoes endoplasmic reticulum (ER)-associated degradation that is subject to ..
  75. pmc High-mobility group box proteins modulate tumor necrosis factor-alpha expression in osteoclastogenesis via a novel deoxyribonucleic acid sequence
    Kosj Yamoah
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Endocrinol 22:1141-53. 2008
    ..We further show how RANKL treatment stimulates the high-mobility group box proteins (HMGB) HMGB1 and HMGB2 to bind the RANKL-responsive sequence and up-regulates TNFalpha transcription...
  76. ncbi Human mitochondrial transcription factor A possesses multiple subcellular targeting signals
    Viktoriya Pastukh
    Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, AL 36688, USA
    FEBS J 274:6488-99. 2007
    ..Three regions of hTFAM [HMG-like domain 1 (HMG1) and HMG-like domain 2 (HMG2), as well as the tail region] can effect nuclear accumulation of enhanced green fluorescent protein (EGFP) fusions...
  77. pmc Genome-wide alterations in gene methylation by the BRAF V600E mutation in papillary thyroid cancer cells
    Peng Hou
    Laboratory for Cellular and Molecular Thyroid Research, Division of Endocrinology and Metabolism, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Endocr Relat Cancer 18:687-97. 2011
    ..Our results demonstrated that the HMGB2 gene played a role in PTC cell proliferation and the FDG1 gene in cell invasion...
  78. pmc Ssz1 restores endoplasmic reticulum-associated protein degradation in cells expressing defective cdc48-ufd1-npl4 complex by upregulating cdc48
    Eran Bosis
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Genetics 184:695-706. 2010
    ..A pSSZ1 plasmid restored impaired ERAD-M of 6myc-Hmg2 in cdc48-10, ufd1-2, and npl4-1, while SSZ1 deletion had no effect. Ssz1p activates Pdr1p, the PDR master regulator...
  79. pmc Increasing the number of thyroid lesions classes in microarray analysis improves the relevance of diagnostic markers
    Jean Fred Fontaine
    Max Delbruck Center for Molecular Medicine, Berlin, Germany
    PLoS ONE 4:e7632. 2009
    ..Our own dataset, containing about half the thyroid tissue samples, included all categories of thyroid lesions...
  80. pmc Unexpected mobility of plant chromatin-associated HMGB proteins
    Thomas Merkle
    Faculty of Biology and Institute for Genome Research and Systems Biology, Bielefeld University, Bielefeld, Germany
    Plant Signal Behav 6:878-80. 2011
    ..Recent studies revealed that Arabidopsis HMGB2/3 and B4 proteins are predominantly nuclear but also exist in the cytoplasm, suggesting an as yet unknown ..
  81. pmc A human HMG2 cDNA with a novel 3'-untranslated region
    S Alexandre
    Department of Biochemistry, Norris Cancer Research Center, University of Southern California School of Medicine, Los Angeles 90033
    Nucleic Acids Res 20:6413. 1992
  82. ncbi Localization of the binding region of high mobility group protein 2 to cisplatin-damaged DNA
    D L Lawrence
    Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104
    J Biol Chem 268:23940-5. 1993
    ..In the present study partial proteolytic digestion was used to localize the binding region of HMG2. A proteolytic fragment of approximately 20 kDa, containing the amino-terminal region of the protein, maintains the ..
  83. ncbi PCR amplification of SRY-related gene sequences reveals evolutionary conservation of the SRY-box motif
    A M Coriat
    Department of Cell and Structural Biology, University of Manchester, UK
    PCR Methods Appl 2:218-22. 1993
    ..shares a high degree of homology with a DNA-binding domain found in the high-mobility-group (HMG) proteins HMG1 and HMG2. The SRY box motif is highly conserved in several sequence-specific DNA-binding proteins that are known to act as ..
  84. pmc Ancestry and diversity of the HMG box superfamily
    V Laudet
    CNRS URA 1160, Institut Pasteur, Lille, France
    Nucleic Acids Res 21:2493-501. 1993
    ..The HMG box superfamily comprises a.o. the High Mobility Group proteins HMG1 and HMG2, the nucleolar transcription factor UBF, the lymphoid transcription factors TCF-1 and LEF-1, the fungal mating-type ..
  85. ncbi High mobility group proteins 1 and 2 recognize chromium-damaged DNA
    J F Wang
    Department of Pathology, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104 6002, USA
    Carcinogenesis 18:371-5. 1997
    ..Protein binding was lesion density-dependent, with maximal binding to DNA treated with 100 microM CrCl3. HMG2 binds to Cr-DNA with a calculated Kd of approximately 10(-9) M...
  86. ncbi High mobility group proteins 1 and 2 can function as DNA-binding regulatory components for DNA-dependent protein kinase in vitro
    Y Yumoto
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda ku, Tokyo 101 0062, Japan
    J Biochem 124:519-27. 1998
    ..The HMG2-domains (A+B) polypeptide devoid of the C-terminal acidic region was more effective for DNA-PKcs stimulation than ..
  87. ncbi Selection of a cDNA clone for chicken high-mobility-group 1 (HMG1) protein through its unusually conserved 3'-untranslated region, and improved expression of recombinant HMG1 in Escherichia coli
    K B Lee
    Cambridge Centre for Molecular Recognition and Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Gene 225:97-105. 1998
    ..HMG) 1 and 2 using DNA probes based on the coding sequences is likely to result in isolation of both HMG1 and HMG2 clones, as well as pseudogenes, which may be transcribed at low levels...
  88. ncbi Cloning and analysis of an HMG gene from the lamprey Lampetra fluviatilis: gene duplication in vertebrate evolution
    A C Sharman
    School of Animal and Microbial Sciences, The University of Reading, Whiteknights, UK
    Gene 184:99-105. 1997
    ..Molecular phylogenetic analysis shows that LfHMG1 is descended from a gene ancestral to mammalian HMG1 and HMG2. This implies that there was a duplication event in the HMG1/2 gene family, that occurred after the divergence of ..
  89. pmc Expression of the Arabidopsis HMG2 gene, encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase, is restricted to meristematic and floral tissues
    M Enjuto
    Departament de Bioquimica i Fisiologia, Facultat de Quimica, Universitat de Barcelona, Spain
    Plant Cell 7:517-27. 1995
    ..1.1.34). In Arabidopsis, HMGR is encoded by two differentially expressed genes (HMG1 and HMG2)...
  90. pmc HMG-D is an architecture-specific protein that preferentially binds to DNA containing the dinucleotide TG
    M E Churchill
    Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
    EMBO J 14:1264-75. 1995
    ..is a highly abundant chromosomal protein that is closely related to the vertebrate HMG domain proteins HMG1 and HMG2. In general, chromosomal HMG domain proteins lack sequence specificity...
  91. pmc Sequence of human HMG2 cDNA
    A Majumdar
    Otsuka Pharmaceuticals, Rockville, MD 20850
    Nucleic Acids Res 19:6643. 1991
  92. ncbi Primary structure of non-histone chromosomal protein HMG2 revealed by the nucleotide sequence
    H Shirakawa
    Department of Biological Science and Technology, Science University of Tokyo, Chiba, Japan
    Biochemistry 29:4419-23. 1990
    The isolation and sequencing of a cDNA clone for the entire sequence of pig thymus non-histone protein HMG2 are described. cDNA the size of 1153 nucleotides contains an open reading frame of 627 nucleotides...
  93. ncbi Isolation and structural characterization of a cDNA encoding Arabidopsis thaliana 3-hydroxy-3-methylglutaryl coenzyme A reductase
    C Caelles
    Unitat de Bioquimica, Facultat de Farmacia, Universitat de Barcelona, Spain
    Plant Mol Biol 13:627-38. 1989
    ..A. thaliana contains two different HMG-CoA reductase genes (HMG1 and HMG2), as estimated by gene cloning and Southern blot analysis. Northern blot analysis reveals a single transcript of 2...
  94. ncbi Tissue specificity of nucleo-cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions
    M I Mosevitsky
    Leningrad Nuclear Physics Institute, Academy of Sciences of the USSR, Gatchina
    Eur J Biochem 185:303-10. 1989
    The levels and distribution between nucleus and cytoplasm of HMG1 and HMG2 proteins have been investigated in different tissues of mammals...
  95. pmc Identifying mutations in duplicated functions in Saccharomyces cerevisiae: recessive mutations in HMG-CoA reductase genes
    M E Basson
    Department of Biochemistry, University of California, Berkeley 94720
    Genetics 117:645-55. 1987
    The two yeast genes for 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, HMG1 and HMG2, each encode a functional isozyme...
  96. pmc Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis
    M E Basson
    Department of Biochemistry, University of California, Berkeley 94720
    Mol Cell Biol 8:3797-808. 1988
    ..acid sequence of the two yeast HMG-CoA reductase isozymes was deduced from DNA sequence analysis of the HMG1 and HMG2 genes...
  97. pmc Structure and function of a human transcription factor TFIIIB subunit that is evolutionarily conserved and contains both TFIIB- and high-mobility-group protein 2-related domains
    Z Wang
    Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 92:7026-30. 1995
    ..The C-terminal half of TFIIIB90 contains a high-mobility-group protein 2 (HMG2)-related domain and interacts strongly with TBP...
  98. pmc High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors
    S Zwilling
    Zentrum für Molekulare Biologie Heidelberg, Germany
    EMBO J 14:1198-208. 1995
    ..We have mapped the interaction domains for both proteins and have shown that HMG2 and Oct2 interact via their HMG domains and POU homeodomains, respectively...
  99. ncbi Differential chromatin association and nucleosome binding of the maize HMGA, HMGB, and SSRP1 proteins
    J Lichota
    Department of Life Science, Aalborg University, Sohngaardsholmsvej 49, DK 9000 Aalborg, Denmark
    Biochemistry 40:7860-7. 2001
    ..This was confirmed by treatment of chromatin with micrococcal nuclease, demonstrating that the HMGA, HMGB2/3, and SSRP1 proteins are enriched in the highly nuclease-sensitive fraction of chromatin, which is likely to be ..
  100. pmc HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A
    Zusen Fan
    Center for Blood Research and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 22:2810-20. 2002
    ..find that the SET complex contains DNA binding and bending activities mediated by the chromatin-associated protein HMG2. HMG2 facilitates assembly of nucleoprotein higher-order structures by bending and looping DNA or by stabilizing ..

Research Grants39

  1. HMGB2 in cartilage homeostasis, aging and osteoarthritis
    Martin K Lotz; Fiscal Year: 2010
    ..Our preliminary studies show that the chromatin protein HMGB2 is exclusively expressed in the SZ of articular cartilage...
  2. Investigating the Molecular Basis of FSHD
    Rossella Tupler; Fiscal Year: 2007
    ..Through biochemical purification, we have isolated three proteins, YYI, HMGB2, and nucleolin, forming a multi-protein complex that binds D4Z4...
  3. END JOINING REACTION IN DNA REPAIR & V(D)J RECOMBINATION
    Gilbert Chu; Fiscal Year: 2001
    ..by protein purification and by testing specific candidates, including XRCC4, DNA ligases I and IV, RPA, HMG1 and HMG2. Once the initial steps have been characterized, a search will be conducted for the complete end-joining reaction ..
  4. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2006
    ..and an A/T-rich sequence, recognized by a cardiac-specific 42 kDa proteins and a ubiquitous high mobility group 2 (HMG2) protein, respectively. Additionally, F contains a MEF2-like motif, which has an A/T-rich core...
  5. Targeting of somatic hypermutation and gene conversion
    David Schatz; Fiscal Year: 2006
    ..The results of these experiments should set the stage for significant progress toward an understanding of the mechanism by which protein factors and DNA sequences collaborate to target SM and GC to Ig genes. ..
  6. IMMUNOGLOBULIN AND T CELL RECEPTOR GENE ASSEMBLY
    David Schatz; Fiscal Year: 2007
    ..These aberrations contribute to the development of certain blood cancers and it is hoped that this work will provide insights into the causes of these mistakes. ..
  7. INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAM
    David Schatz; Fiscal Year: 2007
    ..Such research is expected to yield new vaccines, new therapies to combat viruses and bacteria, and new treatments for autoimmune diseases such as diabetes, lupus, and rheumatoid arthritis and hypersensitivity disorders such as asthma. ..
  8. Mitochondrial Abnormalities in Schizophrenia and Bipolar Disorder
    MARQUIS PHILIP VAWTER; Fiscal Year: 2010
    ..By understanding the accumulation of mitochondrial DNA defects in brain, it will advance mitochondrial medicine for earlier diagnosis and treatment of brain related disorders. ..
  9. Biomarker Genes in Mood Disorder: Lymphocyte and Brain
    MARQUIS VAWTER; Fiscal Year: 2006
    ..The potential use of biomarkers in lymphocytes will provide clinical researchers a tool to better address questions concerning diagnostic subgroups and treatment responders and non-responders. ..
  10. IMMUNOGLOBULIN AND T CELL RECEPTOR GENE ASSEMBLY
    David Schatz; Fiscal Year: 2006
    ..Overall, our experiments will address both the targeting and rejoining functions of the RAG proteins, with the long term goal of linking these fundamental activities to chromosomal translocations found in human malignancies. ..
  11. IMMUNOGLOBULIN AND T CELL RECEPTOR GENE ASSEMBLY
    David Schatz; Fiscal Year: 1993
    ..Identification of the components of the enzyme and an understanding of the role each plays in the recombination reaction should provide insights into the mechanisms by which defects in the reaction lead to human disease...
  12. IMMUNOGLOBULIN AND T CELL RECEPTOR GENE ASSEMBLY
    David Schatz; Fiscal Year: 2001
    ..Identification of the components of the enzyme and an understanding of the role each plays in the recombination reaction should provide insights into the mechanisms by which defects in the reaction lead to human disease. ..