HMGA2

Summary

Gene Symbol: HMGA2
Description: high mobility group AT-hook 2
Alias: BABL, HMGI-C, HMGIC, LIPO, STQTL9, high mobility group protein HMGI-C, HMGA2/KRT121P fusion, high-mobility group (nonhistone chromosomal) protein isoform I-C
Species: human
Products:     HMGA2

Top Publications

  1. Brants J, Ayoubi T, Chada K, Marchal K, Van de Ven W, Petit M. Differential regulation of the insulin-like growth factor II mRNA-binding protein genes by architectural transcription factor HMGA2. FEBS Lett. 2004;569:277-83 pubmed
    The developmentally regulated architectural transcription factor, high mobility group A2 (HMGA2), is involved in growth regulation and plays an important role in embryogenesis and tumorigenesis...
  2. Malek A, Bakhidze E, Noske A, Sers C, Aigner A, Schafer R, et al. HMGA2 gene is a promising target for ovarian cancer silencing therapy. Int J Cancer. 2008;123:348-356 pubmed publisher
    ..In our previous work, we showed upregulation of HMGA2 gene expression as a result of Ras-induced rat ovarian surface epithelial cell transformation...
  3. Taal H, Pourcain B, Thiering E, Das S, Mook Kanamori D, Warrington N, et al. Common variants at 12q15 and 12q24 are associated with infant head circumference. Nat Genet. 2012;44:532-538 pubmed publisher
  4. Crombez K, Vanoirbeek E, Van de Ven W, Petit M. Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2. Mol Cancer Res. 2005;3:63-70 pubmed
    The gene encoding the architectural transcription factor HMGA2 is frequently rearranged in several benign tumors of mesenchymal origin...
  5. Watanabe S, Ueda Y, Akaboshi S, Hino Y, Sekita Y, Nakao M. HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am J Pathol. 2009;174:854-68 pubmed publisher
    ..The high-mobility group A protein 2 (HMGA2) is a non-histone chromatin factor that is primarily expressed in undifferentiated tissues and tumors of ..
  6. Lettre G, Jackson A, Gieger C, Schumacher F, Berndt S, Sanna S, et al. Identification of ten loci associated with height highlights new biological pathways in human growth. Nat Genet. 2008;40:584-91 pubmed publisher
    ..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. ..
  7. Chiappetta G, Ferraro A, Vuttariello E, Monaco M, Galdiero F, De Simone V, et al. HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias. Eur J Cancer. 2008;44:1015-21 pubmed publisher
    We have analysed the expression of the HMGA2 gene in a panel of normal and neoplastic thyroid tissues by immunohistochemistry and quantitative RT-PCR...
  8. Wu J, Liu Z, Shao C, Gong Y, Hernando E, Lee P, et al. HMGA2 overexpression-induced ovarian surface epithelial transformation is mediated through regulation of EMT genes. Cancer Res. 2011;71:349-59 pubmed publisher
    The AT-hook transcription factor HMGA2 is an oncogene involved in the tumorigenesis of many malignant neoplasms. HMGA2 overexpression is common in both early and late-stage high-grade ovarian serous papillary carcinoma...
  9. von Ahsen I, Rogalla P, Bullerdiek J. Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15). Cancer Genet Cytogenet. 2005;163:68-70 pubmed
    ..t(3;12)(q27 approximately 28; q14 approximately 15) in lipomas and pulmonary chondroid hamartomas (PCHs) makes the HMGA2-LPP fusion gene the most frequent fusion gene in human tumors...

More Information

Publications62

  1. Hristov A, Cope L, Reyes M, Singh M, Iacobuzio Donahue C, Maitra A, et al. HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Mod Pathol. 2009;22:43-9 pubmed publisher
    ..The high mobility group A2 (HMGA2) protein is an architectural transcription factor that has recently been implicated in the development and ..
  2. Park S, Shell S, Radjabi A, Schickel R, Feig C, Boyerinas B, et al. Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle. 2007;6:2585-90 pubmed
    ..expression of a number of genes such as c-myc and RAS as well as the embryonic gene high mobility group, A2 (HMGA2). We now demonstrate that HMGA2 is more efficiently targeted by let-7 than RAS...
  3. Klemke M, Meyer A, Nezhad M, Bartnitzke S, Drieschner N, Frantzen C, et al. Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease. Genes Chromosomes Cancer. 2009;48:171-8 pubmed publisher
    An overexpression of HMGA2 is supposed to be a key event in the genesis of leiomyoma with chromosomal rearrangements affecting the region 12q14-15 targeting the HMGA2 gene, but gene expression data regarding differences between uterine ..
  4. Weedon M, Lettre G, Freathy R, Lindgren C, Voight B, Perry J, et al. A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet. 2007;39:1245-50 pubmed
    ..Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P = 4 x 10(-8))...
  5. Cleynen I, Van de Ven W. The HMGA proteins: a myriad of functions (Review). Int J Oncol. 2008;32:289-305 pubmed
    ..members: HMGA1a, HMGA1b and HMGA1c, which result from translation of alternative spliced forms of one gene and HMGA2, which is encoded for by another gene...
  6. Abe N, Watanabe T, Suzuki Y, Matsumoto N, Masaki T, Mori T, et al. An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue. Br J Cancer. 2003;89:2104-9 pubmed
    The altered form of the high-mobility group A2 (HMGA2) gene is somehow related to the generation of human benign and malignant tumours of mesenchymal origin...
  7. Weedon M, Lango H, Lindgren C, Wallace C, Evans D, Mangino M, et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet. 2008;40:575-83 pubmed publisher
    ..genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes...
  8. Cleynen I, Brants J, Peeters K, Deckers R, Debiec Rychter M, Sciot R, et al. HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB. Mol Cancer Res. 2007;5:363-72 pubmed
    ..We recently identified the Imp2 gene as a target gene of the architectural transcription factor HMGA2 (high mobility group A2) and its tumor-specific truncated form HMGA2Tr...
  9. Fedele M, Visone R, De Martino I, Troncone G, Palmieri D, Battista S, et al. HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity. Cancer Cell. 2006;9:459-71 pubmed
    b>HMGA2 gene amplification and overexpression in human prolactinomas and the development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role in pituitary tumorigenesis...
  10. Cattaruzzi G, Altamura S, Tessari M, Rustighi A, Giancotti V, Pucillo C, et al. The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function. Nucleic Acids Res. 2007;35:1751-60 pubmed
    ..Here, we report the identification and characterization of a nuclear localization signal (NLS) for HMGA2, a member of the HMGA family...
  11. Soranzo N, Rivadeneira F, Chinappen Horsley U, Malkina I, Richards J, Hammond N, et al. Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size. PLoS Genet. 2009;5:e1000445 pubmed publisher
    ..Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height. ..
  12. Lappinga P, Kip N, Jin L, Lloyd R, Henry M, Zhang J, et al. HMGA2 gene expression analysis performed on cytologic smears to distinguish benign from malignant thyroid nodules. Cancer Cytopathol. 2010;118:287-97 pubmed publisher
    ..Studies using paraffin-embedded tissue have indicated that high mobility group AT-hook 2 (HMGA2) overexpression is present in a high percentage of malignant thyroid neoplasms but not in benign thyroid neoplasms...
  13. Borrmann L, Schwanbeck R, Heyduk T, Seebeck B, Rogalla P, Bullerdiek J, et al. High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity. Nucleic Acids Res. 2003;31:6841-51 pubmed
    High mobility group A2 (HMGA2) chromosomal non-histone protein and its derivatives play an important role in development and progression of benign and malignant tumors, obesity and arteriosclerosis, although the underlying mechanisms of ..
  14. Miyazawa J, Mitoro A, Kawashiri S, Chada K, Imai K. Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity. Cancer Res. 2004;64:2024-9 pubmed
    ..b>HMGA2 is an architectural transcriptional factor that is expressed in the undifferentiated mesenchyme and initiates ..
  15. Gross K, Neskey D, Manchanda N, Weremowicz S, Kleinman M, Nowak R, et al. HMGA2 expression in uterine leiomyomata and myometrium: quantitative analysis and tissue culture studies. Genes Chromosomes Cancer. 2003;38:68-79 pubmed
    The high mobility group gene, HMGA2, is frequently expressed in uterine leiomyomata (UL) with chromosomal rearrangements of 12q15...
  16. Reeves R, Beckerbauer L. HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Biochim Biophys Acta. 2001;1519:13-29 pubmed
  17. Pierron A, Fernandez C, Saada E, Keslair F, Hery G, Zattara H, et al. HMGA2-NFIB fusion in a pediatric intramuscular lipoma: a novel case of NFIB alteration in a large deep-seated adipocytic tumor. Cancer Genet Cytogenet. 2009;195:66-70 pubmed publisher
    ..characterized by aberrations of the 12q13 approximately q15 chromosomal region and often by rearrangements of the HMGA2 gene...
  18. Enlund F, Nordkvist A, Sahlin P, Mark J, Stenman G. Expression of PLAG1 and HMGIC proteins and fusion transcripts in radiation-associated pleomorphic adenomas. Int J Oncol. 2002;20:713-6 pubmed
    ..adenomas without gross rearrangements of these breakpoints show simultaneous overexpression of the PLAG1 and HMGIC genes, i.e. the target genes of the 8q12 and 12q14-15 rearrangements in sporadic adenomas...
  19. Mayr C, Hemann M, Bartel D. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science. 2007;315:1576-9 pubmed
    ..chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 (Hmga2) by let-7 miRNA...
  20. Ashar H, Fejzo M, Tkachenko A, Zhou X, Fletcher J, Weremowicz S, et al. Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell. 1995;82:57-65 pubmed
    ..These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation. ..
  21. Di Cello F, Hillion J, Hristov A, Wood L, Mukherjee M, Schuldenfrei A, et al. HMGA2 participates in transformation in human lung cancer. Mol Cancer Res. 2008;6:743-50 pubmed publisher
    ..studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the role of HMGA2 (formerly HMGI-C) in malignant transformation has not been clearly defined...
  22. Hebert C, Norris K, Scheper M, Nikitakis N, Sauk J. High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma. Mol Cancer. 2007;6:5 pubmed
    b>HMGA2 expression has been shown to be associated with enhanced selective chemosensitivity towards the topoisomerase (topo) II inhibitor, doxorubicin, in cancer cells...
  23. Pillas D, Hoggart C, Evans D, O Reilly P, Sipilä K, Lähdesmäki R, et al. Genome-wide association study reveals multiple loci associated with primary tooth development during infancy. PLoS Genet. 2010;6:e1000856 pubmed publisher
    ..loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer...
  24. Thuault S, Valcourt U, Petersen M, Manfioletti G, Heldin C, Moustakas A. Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J Cell Biol. 2006;174:175-83 pubmed
    ..Transcriptomic analysis revealed that the high mobility group A2 (HMGA2) gene is induced by the Smad pathway during EMT...
  25. Ashar H, Tkachenko A, Shah P, Chada K. HMGA2 is expressed in an allele-specific manner in human lipomas. Cancer Genet Cytogenet. 2003;143:160-8 pubmed
    The architectural transcription factor HMGA2 is almost exclusively expressed in undifferentiated mesenchymal cells...
  26. Gattas G, Quade B, Nowak R, Morton C. HMGIC expression in human adult and fetal tissues and in uterine leiomyomata. Genes Chromosomes Cancer. 1999;25:316-22 pubmed
    The high-mobility-group (HMG) protein gene, HMGIC, is localized to chromosome 12, band q15, a region often rearranged in benign mesenchymal tumors, including uterine leiomyomata...
  27. Summer H, Li O, Bao Q, Zhan L, Peter S, Sathiyanathan P, et al. HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy. Nucleic Acids Res. 2009;37:4371-84 pubmed publisher
    ..Intriguingly, HMGA2 is also found in rare tumor-inducing cells which are resistant to chemotherapy...
  28. Nilsson M, Mertens F, Hoglund M, Mandahl N, Panagopoulos I. Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15. Cytogenet Genome Res. 2006;112:60-6 pubmed
    ..The HMGA2 gene is often rearranged, but little is known about the molecular consequences at other breakpoints...
  29. Dahlén A, Mertens F, Rydholm A, Brosjo O, Wejde J, Mandahl N, et al. Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. Mod Pathol. 2003;16:1132-40 pubmed
    ..The HMGA2 (HMGI-C) locus in 12q15 is frequently rearranged in other benign mesenchymal tumors, and this study aimed at ..
  30. Horikoshi M, Yaghootkar H, Mook Kanamori D, Sovio U, Taal H, Hennig B, et al. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet. 2013;45:76-82 pubmed publisher
    ..ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height...
  31. Boo L, Lin H, Chung V, Zhou B, Louie S, O Reilly M, et al. High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation. Cancer Res. 2005;65:6622-30 pubmed
    The high mobility group A2 (HMGA2) protein belongs to the architectural transcription factor HMGA family, playing a role in chromosomal organization and transcriptional regulation...
  32. Markowski D, Bartnitzke S, Belge G, Drieschner N, Helmke B, Bullerdiek J. Cell culture and senescence in uterine fibroids. Cancer Genet Cytogenet. 2010;202:53-7 pubmed publisher
    ..Also, the tremendous differences in the expression of the high mobility group protein HMGA2 seen when comparing fibroids of different genetic subtypes are surprisingly not reflected by significant ..
  33. Motoyama K, Inoue H, Nakamura Y, Uetake H, Sugihara K, Mori M. Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family. Clin Cancer Res. 2008;14:2334-40 pubmed publisher
    The high mobility group A2 (HMGA2) nonhistone chromosomal protein can modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during embryogenesis and in various benign and malignant tumors...
  34. Thuault S, Tan E, Peinado H, Cano A, Heldin C, Moustakas A. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J Biol Chem. 2008;283:33437-46 pubmed publisher
    ..We previously reported that the high mobility group A2 (HMGA2) gene is required for TGF-beta to elicit EMT in mammary epithelial cells...
  35. Rice S, Lai S, Wood L, Helsley K, Runkle E, Winslow M, et al. MicroRNA-33a mediates the regulation of high mobility group AT-hook 2 gene (HMGA2) by thyroid transcription factor 1 (TTF-1/NKX2-1). J Biol Chem. 2013;288:16348-60 pubmed publisher
    ..It was reported that the oncogenic proepithelial mesenchymal transition (EMT) high mobility group AT-hook 2 gene (HMGA2) mediates the antimetastatic function of TTF-1...
  36. Stein J, Medland S, Vasquez A, Hibar D, Senstad R, Winkler A, et al. Identification of common variants associated with human hippocampal and intracranial volumes. Nat Genet. 2012;44:552-61 pubmed publisher
    ..Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 × 10(-12))...
  37. Li A, Lin H, Kuo C, Shih H, Wang C, Yen Y, et al. High-mobility group A2 protein modulates hTERT transcription to promote tumorigenesis. Mol Cell Biol. 2011;31:2605-17 pubmed publisher
    The high-mobility group A2 gene (HMGA2) is one of the most frequently amplified genes in human cancers. However, functions of HMGA2 in tumorigenesis are not fully understood due to limited knowledge of its targets in tumor cells...
  38. Tessari M, Gostissa M, Altamura S, Sgarra R, Rustighi A, Salvagno C, et al. Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2. Mol Cell Biol. 2003;23:9104-16 pubmed
    The HMGA2 protein belongs to the HMGA family of architectural transcription factors, which play an important role in chromatin organization...
  39. Odero M, Grand F, Iqbal S, Ross F, Roman J, Vizmanos J, et al. Disruption and aberrant expression of HMGA2 as a consequence of diverse chromosomal translocations in myeloid malignancies. Leukemia. 2005;19:245-52 pubmed
    Chromosomal translocations that target HMGA2 at chromosome band 12q14 are seen in a variety of malignancies, notably lipoma, pleomorphic salivary adenoma and uterine leiomyoma...
  40. Sanna S, Jackson A, Nagaraja R, Willer C, Chen W, Bonnycastle L, et al. Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet. 2008;40:198-203 pubmed publisher
    ..reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population...
  41. Narita M, Narita M, Krizhanovsky V, Nũnez S, Chicas A, Hearn S, et al. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell. 2006;126:503-14 pubmed
    ..activities are canceled by coexpression of the HDM2 and CDK4 oncogenes, which are often coamplified with HMGA2 in human cancers...
  42. Li O, Vasudevan D, Davey C, Droge P. High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells. Genesis. 2006;44:523-9 pubmed
    ..The non-histone chromatin-associated factor HMGA2 has been studied mostly in the mouse where its function seems critical for embryonic cell growth and adipocytic ..
  43. Lee Y, Dutta A. The tumor suppressor microRNA let-7 represses the HMGA2 oncogene. Genes Dev. 2007;21:1025-30 pubmed
    b>HMGA2, a high-mobility group protein, is oncogenic in a variety of tumors, including benign mesenchymal tumors and lung cancers...
  44. Italiano A, Bianchini L, Keslair F, Bonnafous S, Cardot Leccia N, Coindre J, et al. HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon. Int J Cancer. 2008;122:2233-41 pubmed publisher
    ..In addition, using quantitative RT-PCR we studied the expression of MDM2, CDK4, DDIT3 (CHOP/GADD153), DYRK2, HMGA2, TSPAN31 and YEATS4 (GAS41) in 11 cases. We showed that CDK4 (12q14...
  45. Li A, Boo L, Wang S, Lin H, Wang C, Yen Y, et al. Suppression of nonhomologous end joining repair by overexpression of HMGA2. Cancer Res. 2009;69:5699-706 pubmed publisher
    Understanding the molecular details associated with aberrant high mobility group A2 (HMGA2) gene expression is key to establishing the mechanism(s) underlying its oncogenic potential and effect on the development of therapeutic ..
  46. Geller F, Feenstra B, Zhang H, Shaffer J, Hansen T, Esserlind A, et al. Genome-wide association study identifies four loci associated with eruption of permanent teeth. PLoS Genet. 2011;7:e1002275 pubmed publisher
    ..5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles. ..
  47. Schoenmakers E, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H, Van de Ven W. Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet. 1995;10:436-44 pubmed
    ..These results suggest a link between a member of the HMG gene family and benign solid tumour development. ..
  48. Noro B, Licheri B, Sgarra R, Rustighi A, Tessari M, Chau K, et al. Molecular dissection of the architectural transcription factor HMGA2. Biochemistry. 2003;42:4569-77 pubmed
    b>HMGA2 protein belongs to the High Mobility Group A (HMGA) family of architectural transcription factors...
  49. Belge G, Meyer A, Klemke M, Burchardt K, Stern C, Wosniok W, et al. Upregulation of HMGA2 in thyroid carcinomas: a novel molecular marker to distinguish between benign and malignant follicular neoplasias. Genes Chromosomes Cancer. 2008;47:56-63 pubmed
    ..Herein, we have used the expression of the high mobility group protein gene HMGA2 and its protein, respectively, as a possible marker detecting malignant growth of thyroid tumors...
  50. Manfioletti G, Giancotti V, Bandiera A, Buratti E, Sautiere P, Cary P, et al. cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes. Nucleic Acids Res. 1991;19:6793-7 pubmed
    ..Analysis of mRNA levels demonstrate that the HMGI-C gene is not expressed in a variety of mouse tissues but is expressed in Lewis lung carcinoma cells. ..
  51. Meyer B, Loeschke S, Schultze A, Weigel T, Sandkamp M, Goldmann T, et al. HMGA2 overexpression in non-small cell lung cancer. Mol Carcinog. 2007;46:503-11 pubmed
    ..Overexpression of the high mobility group protein HMGA2 has been observed in a variety of malignant tumors and often correlates with poor prognosis...
  52. Li O, Li J, Droge P. DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells. FEBS Lett. 2007;581:3533-7 pubmed
    ..We showed recently that among the major HMG proteins, HMGA2 is highly expressed in two human embryonic stem (hES) cell lines...
  53. Ashar H, Cherath L, Przybysz K, Chada K. Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas. Genomics. 1996;31:207-14 pubmed
    b>HMGIC, a member of the HMGI family of high mobility group proteins, is disrupted in 3/3 lipomas characterized by 12q14-q15 rearrangements...