HMGA2

Summary

Gene Symbol: HMGA2
Description: high mobility group AT-hook 2
Alias: BABL, HMGI-C, HMGIC, LIPO, STQTL9, High-mobility group protein HMGI-C, high mobility group AT-hook protein 2, high mobility group protein HMGI-C, high-mobility group (nonhistone chromosomal) protein isoform I-C
Species: human

Top Publications

  1. pmc Common variants at 12q15 and 12q24 are associated with infant head circumference
    H Rob Taal
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:532-8. 2012
  2. pmc Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    Christine Mayr
    Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 315:1576-9. 2007
  3. ncbi The HMGA proteins: a myriad of functions (Review)
    Isabelle Cleynen
    Laboratory of Molecular Oncology, Department of Human Genetics, University of Leuven, Herestraat 49 bus 602, Leuven, Belgium
    Int J Oncol 32:289-305. 2008
  4. ncbi A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
    Masashi Narita
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell 126:503-14. 2006
  5. pmc HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 22:43-9. 2009
  6. pmc HMGA2 participates in transformation in human lung cancer
    Francescopaolo Di Cello
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 6:743-50. 2008
  7. pmc Genome-wide association study identifies four loci associated with eruption of permanent teeth
    Frank Geller
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    PLoS Genet 7:e1002275. 2011
  8. pmc cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes
    G Manfioletti
    Universita di Trieste, Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Italy
    Nucleic Acids Res 19:6793-7. 1991
  9. doi HMGA2 gene is a promising target for ovarian cancer silencing therapy
    Anastasia Malek
    Department of Pharmacology and Toxicology, Philipps University School of Medicine, Marburg, Germany
    Int J Cancer 123:348-56. 2008
  10. pmc Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Uppsala University, SE 751 24 Uppsala, Sweden, and Institut National de la Sante et de la Recherche Medicale, Hopital E Herriot, Lyon Cedex, France
    J Cell Biol 174:175-83. 2006

Detail Information

Publications198 found, 100 shown here

  1. pmc Common variants at 12q15 and 12q24 are associated with infant head circumference
    H Rob Taal
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:532-8. 2012
    ....
  2. pmc Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    Christine Mayr
    Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 315:1576-9. 2007
    ..chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 (Hmga2) by let-7 miRNA...
  3. ncbi The HMGA proteins: a myriad of functions (Review)
    Isabelle Cleynen
    Laboratory of Molecular Oncology, Department of Human Genetics, University of Leuven, Herestraat 49 bus 602, Leuven, Belgium
    Int J Oncol 32:289-305. 2008
    ..members: HMGA1a, HMGA1b and HMGA1c, which result from translation of alternative spliced forms of one gene and HMGA2, which is encoded for by another gene...
  4. ncbi A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation
    Masashi Narita
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Cell 126:503-14. 2006
    ..activities are canceled by coexpression of the HDM2 and CDK4 oncogenes, which are often coamplified with HMGA2 in human cancers...
  5. pmc HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma
    Alexandra C Hristov
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mod Pathol 22:43-9. 2009
    ..The high mobility group A2 (HMGA2) protein is an architectural transcription factor that has recently been implicated in the development and ..
  6. pmc HMGA2 participates in transformation in human lung cancer
    Francescopaolo Di Cello
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 6:743-50. 2008
    ..studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the role of HMGA2 (formerly HMGI-C) in malignant transformation has not been clearly defined...
  7. pmc Genome-wide association study identifies four loci associated with eruption of permanent teeth
    Frank Geller
    Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    PLoS Genet 7:e1002275. 2011
    ..5 (95% confidence interval: 2.9-4.1) fewer permanent teeth than children with 0 or 1 of these alleles...
  8. pmc cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes
    G Manfioletti
    Universita di Trieste, Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Italy
    Nucleic Acids Res 19:6793-7. 1991
    ..Analysis of mRNA levels demonstrate that the HMGI-C gene is not expressed in a variety of mouse tissues but is expressed in Lewis lung carcinoma cells...
  9. doi HMGA2 gene is a promising target for ovarian cancer silencing therapy
    Anastasia Malek
    Department of Pharmacology and Toxicology, Philipps University School of Medicine, Marburg, Germany
    Int J Cancer 123:348-56. 2008
    ..In our previous work, we showed upregulation of HMGA2 gene expression as a result of Ras-induced rat ovarian surface epithelial cell transformation...
  10. pmc Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition
    Sylvie Thuault
    Ludwig Institute for Cancer Research, Uppsala University, SE 751 24 Uppsala, Sweden, and Institut National de la Sante et de la Recherche Medicale, Hopital E Herriot, Lyon Cedex, France
    J Cell Biol 174:175-83. 2006
    ..Transcriptomic analysis revealed that the high mobility group A2 (HMGA2) gene is induced by the Smad pathway during EMT...
  11. pmc Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
    ..reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population...
  12. ncbi HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB
    Isabelle Cleynen
    Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Herestraat 49, Box 602, B 3000 Leuven, Belgium
    Mol Cancer Res 5:363-72. 2007
    ..We recently identified the Imp2 gene as a target gene of the architectural transcription factor HMGA2 (high mobility group A2) and its tumor-specific truncated form HMGA2Tr...
  13. pmc Transcriptional activation of the cyclin A gene by the architectural transcription factor HMGA2
    Michela A Tessari
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole Centre of Excellence in Biocristallography, University of Trieste, Via L Giorgieri 1, 34127 Trieste, Italy
    Mol Cell Biol 23:9104-16. 2003
    The HMGA2 protein belongs to the HMGA family of architectural transcription factors, which play an important role in chromatin organization...
  14. pmc New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
    Momoko Horikoshi
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Nat Genet 45:76-82. 2013
    ..ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height...
  15. doi Identification of novel HMGA2 fusion sequences in lipoma: evidence that deletion of let-7 miRNA consensus binding site 1 in the HMGA2 3' UTR is not critical for HMGA2 transcriptional upregulation
    Xiaoke Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 48:673-8. 2009
    ..Rearrangement of HMGA2 in chromosome band 12q15 has been found in approximately 60-70% of ordinary lipomas with cytogenetic abnormalities...
  16. ncbi The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6
    Riccardo Sgarra
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, University of Trieste, Italy
    J Biol Chem 281:3764-72. 2006
    ..The in vivo association of HMGA and PRMT6 place this yet functionally uncharacterized methyltransferase in the well established functional context of the chromatin structure organization...
  17. ncbi HMGA proteins up-regulate CCNB2 gene in mouse and human pituitary adenomas
    Ivana De Martino
    Istituto di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Italy
    Cancer Res 69:1844-50. 2009
    ..We have recently reported that transgenic mice carrying the Hmga1 or Hmga2 genes under transcriptional control of the cytomegalovirus promoter develop pituitary adenomas secreting prolactin ..
  18. ncbi Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity
    Jun Miyazawa
    Department of Oral and Maxillofacial Surgery, Nippon Dental University, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Cancer Res 64:2024-9. 2004
    ..b>HMGA2 is an architectural transcriptional factor that is expressed in the undifferentiated mesenchyme and initiates ..
  19. pmc High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma
    Carla Hebert
    Diagnostic Sciences and Pathology, University of Maryland Baltimore, Baltimore, Maryland 21201 1586, USA
    Mol Cancer 6:5. 2007
    b>HMGA2 expression has been shown to be associated with enhanced selective chemosensitivity towards the topoisomerase (topo) II inhibitor, doxorubicin, in cancer cells...
  20. pmc The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
    Yong Sun Lee
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 21:1025-30. 2007
    b>HMGA2, a high-mobility group protein, is oncogenic in a variety of tumors, including benign mesenchymal tumors and lung cancers...
  21. pmc Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size
    Nicole Soranzo
    Human Genetics Department, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom
    PLoS Genet 5:e1000445. 2009
    ..Further statistical tests in larger numbers of individuals will be required to verify if the height loci affect height preferentially through these subcomponents of height...
  22. pmc HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
    Heike Summer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:4371-84. 2009
    ..Intriguingly, HMGA2 is also found in rare tumor-inducing cells which are resistant to chemotherapy...
  23. pmc Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
    Demetris Pillas
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 6:e1000856. 2010
    ..loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer...
  24. ncbi Transactivation functions of the tumor-specific HMGA2/LPP fusion protein are augmented by wild-type HMGA2
    Koen R M O Crombez
    Department of Human Genetics, University of Leuven and Flanders Interuniversity Institute for Biotechnology, Herestraat 49 bus 602, B 3000 Leuven, Belgium
    Mol Cancer Res 3:63-70. 2005
    The gene encoding the architectural transcription factor HMGA2 is frequently rearranged in several benign tumors of mesenchymal origin...
  25. ncbi Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15
    M Nilsson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Cytogenet Genome Res 112:60-6. 2006
    ..The HMGA2 gene is often rearranged, but little is known about the molecular consequences at other breakpoints...
  26. ncbi High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Genesis 44:523-9. 2006
    ..The non-histone chromatin-associated factor HMGA2 has been studied mostly in the mouse where its function seems critical for embryonic cell growth and adipocytic ..
  27. doi HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..In addition, using quantitative RT-PCR we studied the expression of MDM2, CDK4, DDIT3 (CHOP/GADD153), DYRK2, HMGA2, TSPAN31 and YEATS4 (GAS41) in 11 cases. We showed that CDK4 (12q14...
  28. ncbi HMGA2 mRNA expression correlates with the malignant phenotype in human thyroid neoplasias
    Gennaro Chiappetta
    Istituto Nazionale dei Tumori, Fondazione Pascale, Via Mariano Semmola, 80131 Naples, Italy
    Eur J Cancer 44:1015-21. 2008
    We have analysed the expression of the HMGA2 gene in a panel of normal and neoplastic thyroid tissues by immunohistochemistry and quantitative RT-PCR...
  29. doi Clinical significance of high mobility group A2 in human gastric cancer and its relationship to let-7 microRNA family
    Kazuo Motoyama
    Department of Molecular and Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Clin Cancer Res 14:2334-40. 2008
    The high mobility group A2 (HMGA2) nonhistone chromosomal protein can modulate transcription by altering chromatin architecture. HMGA2 is highly expressed during embryogenesis and in various benign and malignant tumors...
  30. pmc Identification of ten loci associated with height highlights new biological pathways in human growth
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:584-91. 2008
    ..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait...
  31. ncbi Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours
    E F Schoenmakers
    Laboratory for Molecular Oncology, University of Leuven, Belgium
    Nat Genet 10:436-44. 1995
    ..These results suggest a link between a member of the HMG gene family and benign solid tumour development...
  32. ncbi HMGA2 is expressed in an allele-specific manner in human lipomas
    Hena R Ashar
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Cancer Genet Cytogenet 143:160-8. 2003
    The architectural transcription factor HMGA2 is almost exclusively expressed in undifferentiated mesenchymal cells...
  33. ncbi Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains
    H R Ashar
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    Cell 82:57-65. 1995
    ..These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation...
  34. ncbi Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas
    Anna Dahlén
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Mod Pathol 16:1132-40. 2003
    ..The HMGA2 (HMGI-C) locus in 12q15 is frequently rearranged in other benign mesenchymal tumors, and this study aimed at ..
  35. ncbi Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2
    Sun Mi Park
    The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Cell Cycle 6:2585-90. 2007
    ..expression of a number of genes such as c-myc and RAS as well as the embryonic gene high mobility group, A2 (HMGA2). We now demonstrate that HMGA2 is more efficiently targeted by let-7 than RAS...
  36. pmc High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity
    Lars Borrmann
    Center for Human Genetics, University of Bremen, Leobenerstr ZHG, D 28359 Bremen, Germany
    Nucleic Acids Res 31:6841-51. 2003
    High mobility group A2 (HMGA2) chromosomal non-histone protein and its derivatives play an important role in development and progression of benign and malignant tumors, obesity and arteriosclerosis, although the underlying mechanisms of ..
  37. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes...
  38. pmc A common variant of HMGA2 is associated with adult and childhood height in the general population
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 39:1245-50. 2007
    ..Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P = 4 x 10(-8))...
  39. ncbi HMGA2 overexpression in non-small cell lung cancer
    Britta Meyer
    Centre for Human Genetics, University of Bremen, Bremen, Germany
    Mol Carcinog 46:503-11. 2007
    ..Overexpression of the high mobility group protein HMGA2 has been observed in a variety of malignant tumors and often correlates with poor prognosis...
  40. ncbi Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas
    H R Ashar
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    Genomics 31:207-14. 1996
    b>HMGIC, a member of the HMGI family of high mobility group proteins, is disrupted in 3/3 lipomas characterized by 12q14-q15 rearrangements...
  41. ncbi HMGIC expression in human adult and fetal tissues and in uterine leiomyomata
    G J Gattas
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Chromosomes Cancer 25:316-22. 1999
    The high-mobility-group (HMG) protein gene, HMGIC, is localized to chromosome 12, band q15, a region often rearranged in benign mesenchymal tumors, including uterine leiomyomata...
  42. pmc An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue
    N Abe
    First Department of Surgery, Kyorin University School of Medicine, 6 20 2, Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Br J Cancer 89:2104-9. 2003
    The altered form of the high-mobility group A2 (HMGA2) gene is somehow related to the generation of human benign and malignant tumours of mesenchymal origin...
  43. ncbi Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15)
    Inga von Ahsen
    Center of Human Genetics, University of Bremen, Germany
    Cancer Genet Cytogenet 163:68-70. 2005
    ..t(3;12)(q27 approximately 28; q14 approximately 15) in lipomas and pulmonary chondroid hamartomas (PCHs) makes the HMGA2-LPP fusion gene the most frequent fusion gene in human tumors...
  44. ncbi HMGI/Y proteins: flexible regulators of transcription and chromatin structure
    R Reeves
    Department of Biochemistry Biophysics, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
    Biochim Biophys Acta 1519:13-29. 2001
    ....
  45. ncbi High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation
    Lee Ming Boo
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033 1049, USA
    Cancer Res 65:6622-30. 2005
    The high mobility group A2 (HMGA2) protein belongs to the architectural transcription factor HMGA family, playing a role in chromosomal organization and transcriptional regulation...
  46. ncbi HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    Cancer Cell 9:459-71. 2006
    b>HMGA2 gene amplification and overexpression in human prolactinomas and the development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role in pituitary tumorigenesis...
  47. ncbi DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    FEBS Lett 581:3533-7. 2007
    ..We showed recently that among the major HMG proteins, HMGA2 is highly expressed in two human embryonic stem (hES) cell lines...
  48. pmc The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function
    Giacomo Cattaruzzi
    Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Udine, Italy
    Nucleic Acids Res 35:1751-60. 2007
    ..Here, we report the identification and characterization of a nuclear localization signal (NLS) for HMGA2, a member of the HMGA family...
  49. pmc Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion
    J I da Motta
    Department of Pharmacology, , Brazil
    Br J Pharmacol 112:111-6. 1994
    ..antagonist (BN 50730), a cyclo-oxygenase inhibitor (indomethacin), a lipoxygenase inhibitor (MK-886), a dual type lipo- and cyclo-oxygenase inhibitor (NDGA), a bradykinin antagonist (Hoe 140) or the combination of cetirizine, MK-886, ..
  50. ncbi HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor
    Pei Hui
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Mod Pathol 18:1519-26. 2005
    ..To this end, we explored diagnostic applications of HMGA (HMGA1 and HMGA2) protein immunohistochemistry in comparable groups of synovial sarcoma and malignant peripheral nerve sheath ..
  51. ncbi Targeting and assembly of an oligomeric bacterial enterotoxoid in the endoplasmic reticulum of Saccharomyces cerevisiae
    O Schonberger
    Department of Molecular Biology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Mol Microbiol 5:2663-71. 1991
    ..coli lipoprotein signal sequence attached to the mature sequence of the B subunit of heat-labile enterotoxin (Lipo-EtxB) was expressed in yeast and E. coli. Analyses of cell lysates from Saccharomyces cerevisiae and E...
  52. ncbi Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function
    Deborah S Hunter
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Cancer Res 62:3766-72. 2002
    ..Concomitantly, HMGA2 protein, which was completely absent in normal myometria, was expressed in 16 of 19 Eker leiomyomas...
  53. ncbi HMGA1 and HMGA2 protein expression in mouse spermatogenesis
    Paolo Chieffi
    Dipartimento di Medicina Sperimentale, II Universita di Napoli, Via Costantinopoli 16, 80138 Naples, Italy
    Oncogene 21:3644-50. 2002
    The high-mobility group A (HMGA) nonhistone chromosomal proteins HMGA1 and HMGA2 play a role in determining chromatin structure and in regulating the transcription of several genes...
  54. ncbi Thyroid cell transformation requires the expression of the HMGA1 proteins
    Maria Teresa Berlingieri
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita Degli Studi Di Napoli, Via Pansini 5, 80131 Naples, Italy
    Oncogene 21:2971-80. 2002
    Elevated expression of HMGA1 and HMGA2 proteins is correlated with a highly malignant phenotype in several human tumors...
  55. ncbi Fusion of HMGA2 to COG5 in uterine leiomyoma
    Gopalrao V N Velagaleti
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55906, USA
    Cancer Genet Cytogenet 202:11-6. 2010
    ..Approximately 10% of these tumors contain rearrangements of the chromatin-remodeling gene HMGA2 at the chromosome band 12q14.3. Herein, we report on a uterine leiomyoma with a novel HMGA2 fusion gene...
  56. ncbi High-mobility group protein HMGA2-derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cells
    A Richter
    Centre for Human Genetics, University of Bremen, Bremen, Germany
    Eur Cell Mater 21:355-63. 2011
    In previous research, it was shown that recombinant HMGA2 protein enhances the proliferation of porcine chondrocytes grown in vitro, opening up promising applications of this embryonic architectural transcription factor for tissue ..
  57. ncbi Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice
    H Helen Lin
    Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA, USA
    Eur J Oral Sci 115:30-9. 2007
    High mobility group A2 (HMGA2) protein is a non-histone architectural transcription factor...
  58. pmc SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome
    Xuefei Cao
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA
    Mol Cancer Ther 7:923-34. 2008
    The HMGA2 architectural protein functions in a variety of cellular processes, such as cell growth, transcription regulation, neoplastic transformation, and progression...
  59. doi Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data
    Laurence Bianchini
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 50:442-55. 2011
    The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors (AT) and, second, to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing ..
  60. doi Odontogenic myxofibroma with HMGA2 overexpression and HMGA2 rearrangement
    Katsuaki Sato
    Department of Pathology II, Kanazawa Medical University, Ishikawa, Japan
    Pathol Int 60:760-4. 2010
    ..This report describes the first case of an odontogenic myxofibroma presenting with HMGA2 protein overexpression and HMGA2 rearrangement in a 40-year-old woman. A 2...
  61. ncbi Isolation and characterization of the gene coding for murine high-mobility-group protein HMGI-C
    G Manfioletti
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, Italy
    Gene 167:249-53. 1995
    ..A highly homologous pseudogene is also present in the mouse genome. Our results on Hmgi-c structure provide basic information to carry out further studies on the regulation of its expression...
  62. pmc Genomic structure and expression of the murine Hmgi-c gene
    X Zhou
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    Nucleic Acids Res 24:4071-7. 1996
    ..Since the human homolog is disrupted in a number of tumors, HMGI-C could play an important role in cell proliferation and differentiation during mammalian development...
  63. ncbi Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts
    M Fedele
    Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Naples, Italy
    Oncogene 17:413-8. 1998
    ..The unrearranged wild-type HMGI-C cDNA did not exert any transforming activity. These findings indicate that rearranged forms of HMGI-C play a role in cell transformation...
  64. doi Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases
    Nadège Dreux
    Department of Pathology, Institut Bergonie, 229 Cours de l Argonne, Bordeaux Cedex, France
    Mod Pathol 23:1657-66. 2010
    The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of ..
  65. ncbi [Expression of regulatory T cells and related cytokines in mice allogenic corneal transplantation rejection]
    Xin Wang
    Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China
    Zhonghua Yan Ke Za Zhi 45:1118-26. 2009
    ..To study the changes of CD4(+)CD25(+) and CD8(+)CD103(+) regulatory T cells and their relevant cytokines in corneal allograft transplantation in mice...
  66. pmc Uric acid enhances T cell immune responses to hepatitis B surface antigen-pulsed-dendritic cells in mice
    Xiao Jun Ma
    Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 13:1060-6. 2007
    ..To study the induction of T cellular immune responses in BALB/c mice immunized with uric acid and dendritic cells (DCs) pulsed with hepatitis B virus surface antigen (HBsAg)...
  67. ncbi Current data on ATP-containing liposomes and potential prospects to enhance cellular energy status for hepatic applications
    V Korb
    AGEPS, APHP, Faculté des Sciences Pharmaceutiques et Biologiques Paris Descartes, Paris, F 75006 France
    Crit Rev Ther Drug Carrier Syst 25:305-45. 2008
    ..Second, studies conducted with ATP liposomally entrapped (lipo-ATP) are described, including pharmaco-technical formulation engineering and related models of assessment...
  68. ncbi Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lab Invest 82:5-14. 2002
    ..suggests that factors that contribute to the development of atherosclerosis, ie, oxidatively modified (lipo)proteins, may also participate in glomerular injury...
  69. ncbi Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity
    Ning Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06504 8900, USA
    Am J Dermatopathol 26:267-72. 2004
    ..CD34 and Factor XIIIa staining is commonly used in separating DF from DFSP, but is not always helpful. HMGA1 and HMGA2 genes, members of the high mobility group protein family genes, encode proteins that act as architectural ..
  70. ncbi Bezafibrate affects lipid, lipo- and apolipoprotein pattern in non-insulin-dependent diabetic patients
    G Niort
    Istituto di Medicina Interna, University of Torino, Italy
    Horm Metab Res 25:372-4. 1993
    ..Bezafibrate use was safe and improved the lipid pattern and the apolipoprotein and lipid distribution in the lipoproteins, producing a less atherogenic pattern in our NID diabetics...
  71. ncbi Specific beta-lactam antibiotics inhibit secretion of lipo-beta-lactamase in yeast
    A London
    Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Mol Microbiol 4:2193-200. 1990
    The beta-lactam antibiotic cloxacillin can inhibit secretion of prokaryotic lipo-beta-lactamase into the periplasm of yeast...
  72. ncbi The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?
    Kurt Pfannkuche
    Institute for Neurophysiology, University of Cologne, Robert Koch Str 39, 50931, Cologne, Germany
    Stem Cell Rev 5:224-30. 2009
    ..For example, HMGA2 is involved in transcriptional activation of certain cell proliferation genes, which likely contributes to its ..
  73. doi MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedema
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg i Br, Germany
    Microvasc Res 77:335-9. 2009
    To assess for the first time the morphology of the lymphatic system in patients with lipedema and lipo-lymphedema of the lower extremities by MR lymphangiography.
  74. ncbi [Pulmonary complications in patients with AIDS]
    Shinichi Oka
    AIDS Clinical Center, International Medical Center of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Kekkaku 77:37-40. 2002
    ..LDS was first reported as re-distribution of lipid such as central obesity with or without lipo-atrophy from extremities and/or face...
  75. doi Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion
    Takashi Yamamoto
    Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    Cell Tissue Res 332:245-56. 2008
    ..of Kupffer cells after their elimination by administration of liposome-entrapped dichloromethylene diphosphonate (lipo-MDP)...
  76. pmc Refinement of the 12q14 microdeletion syndrome: primordial dwarfism and developmental delay with or without osteopoikilosis
    Francesca Mari
    Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Eur J Hum Genet 17:1141-7. 2009
    ..Among the deleted genes, HMGA2 is of particular interest in relationship to the aberrant somatic growth in our patient, as HMGA2 variants have ..
  77. ncbi [Effects of alprostadil in prevention of portal vein thrombogenesis after splenectomy and devascularization: a clinical observation of 76 patients with portal hypertension]
    Jian Cang Ma
    Department of General Surgery, Second Affiliated Hospital of Xi an Jiaotong University, Xi an 710004, China
    Zhonghua Yi Xue Za Zhi 88:524-6. 2008
    To investigate the effects of alprostadil (Lipo PGE1) in prevention of portal vein thrombogenesis (PVT) after splenectomy for portal hypertension.
  78. pmc Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity
    Eduardo N Taboada
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada
    BMC Genomics 8:359. 2007
    ..Although sialylated ganglioside-mimicking lipo-oligosaccharide (LOS) structures are the strongest neuropathogenic determinants in C...
  79. ncbi Structural and immunochemical characterization of a Neisseria gonorrhoeae epitope defined by a monoclonal antibody 2C7; the antibody recognizes a conserved epitope on specific lipo-oligosaccharides in spite of the presence of human carbohydrate epitopes
    R Yamasaki
    Department of Biochemistry and Biotechnology, Tottori University, Tottori 680 8553, Japan
    J Biol Chem 274:36550-8. 1999
    b>Lipo-oligosaccharides (LOS) produced by Neisseria gonorrhoeae are important antigenic and immunogenic components of the outer membrane complex...
  80. ncbi The association of lipodystrophy and oxidative stress biomarkers in HIV-infected men
    Helena S Vassimon
    Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Curr HIV Res 8:364-9. 2010
    ..In a cross-sectional study of blood samples from HIV-infected men with lipodystrophy syndrome (HIV+LIPO+ = 10), HIV-infected men without lipodystrophy syndrome (HIV+LIPO- = 22), and healthy subjects (control = 12), the ..
  81. doi Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cells
    Masaru Murakami
    Laboratory of Molecular Biology, Azabu University School of Veterinary Medicine, Sagamihara, Japan
    Mol Biol Rep 37:1279-86. 2010
    ..In epithelial cells, TGF-beta-induced high mobility group A2 (HMGA2) gene product is suggested to down-regulate E-cadherin through up-regulation of zinc-finger transcription factors ..
  82. ncbi Genetic basis of uterine leiomyoma: involvement of high mobility group protein genes
    W J Van de Ven
    Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven, and Flanders Interuniversity Institute for Biotechnology, Belgium
    Eur J Obstet Gynecol Reprod Biol 81:289-93. 1998
    ..12q13-15 or 6p21 has led to the discovery that two members of the high-mobility group (HMG) protein gene family, HMGIC and HMGIY, are frequently rearranged in such tumors...
  83. ncbi Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasion
    Jutamas Ngampasutadol
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 180:3426-35. 2008
    Complement forms a key arm of innate immune defenses against gonococcal infection. Sialylation of gonococcal lipo-oligosaccharide, or expression of porin 1A (Por1A) protein, enables Neisseria gonorrhoeae to bind the alternative pathway ..
  84. pmc Construction and analysis of cells lacking the HMGA gene family
    Brett Beitzel
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Nucleic Acids Res 31:5025-32. 2003
    ..high mobility group A (HMGA) family of non-histone chromosomal proteins is encoded by two related genes, HMGA1 and HMGA2. HMGA proteins are architectural transcription factors that have been found to regulate the transcription of a ..
  85. ncbi A crucial role of a high mobility group protein HMGA2 in cardiogenesis
    Koshiro Monzen
    Department of Cardiovascular Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nat Cell Biol 10:567-74. 2008
    ..This leads to the active transcription of their target genes. Here we show that HMGA2, a member of the HMGA sub-family of HMG proteins, has a critical function in cardiogenesis...
  86. ncbi HMGA1 and HMGA2 rearrangements in mass-forming endometriosis
    Fabiola Medeiros
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 49:630-4. 2010
    ..endometriosis, and six endometriomas were investigated by fluorescence in situ hybridization (FISH) for HMGA1 and HMGA2 loci, performed on paraffin-embedded thin tissue sections with custom-designed probes...
  87. ncbi In nondiabetic, human immunodeficiency virus-infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistance
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Metabolism 54:171-9. 2005
    ..We studied 18 HIV-infected patients with lipodystrophy (LIPO) on antiretroviral therapy and 25 HIV-infected patients without lipodystrophy (controls) of whom 18 were on ..
  88. ncbi [Pharmacodynamics, pharmacokinetics and tissue distribution of liposomal mitoxantrone hydrochloride]
    Cai Xia Wang
    Hebei Pharmaceutical Technology and Engineering Research Center, Shijiazhuang 050051, China
    Yao Xue Xue Bao 45:1565-9. 2010
    ..study is to compare the pharmacodynamics, pharmacokinetics and tissue distribution of liposomal mitoxantrone (Mit-lipo) and free mitoxantrone (Mit-free)...
  89. ncbi Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series
    Apostolia Maria Tsimberidou
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Leuk Lymphoma 47:1062-8. 2006
    The present study aimed to investigate single-agent liposomal all-trans retinoic acid (Lipo-ATRA) in untreated acute promyelocytic leukemia (APL). Induction therapy consisted of Lipo-ATRA 90 mg/m2 i.v. every other day...
  90. ncbi A dose-response study of epidural liposomal bupivacaine in rabbits
    J M Malinovsky
    Laboratoire d Anesthésie et Chirurgie Expérimentale, Universite de Nantes, Nantes, France
    J Control Release 60:111-9. 1999
    ..phosphatidylcholine-cholesterol) suspensions contained 20 mg ml-1 of lipid, and different doses of bupivacaine (Lipo 7.5=7.5-; Lipo 3.7=3. 75-; Lipo 2.5=2.5-; Lipo 1.2=1.25-; and Lipo 0.7=0.65-mg of bupivacaine per ml)...
  91. doi [Contributions and results of lipo-structure in repair and rejuvenation of frontal anatomical unit]
    A Chichery
    Service de Chirurgie Plastique, centre hospitalier Saint Luc et Saint Joseph, 20, Quai Claude Bernard, 69003 Lyon, France
    Ann Chir Plast Esthet 54:93-102. 2009
    ..In this work, we want to estimate contribution of lipo-structure in repair and rejuvenation of frontal anatomical unit (FAU)...
  92. ncbi Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution
    Steen B Haugaard
    Clinical Research Unit, Hvidovre University Hospital, DK 2650 Hvidore, Copenhagen, Denmark
    Metabolism 56:939-46. 2007
    ..To address this issue, the secretion patterns of SP and IP of 16 HIV-infected men with lipodystrophy (LIPO) and 15 HIV-infected men without lipodystrophy (NONLIPO) were studied during an oral glucose tolerance test (OGTT)...
  93. ncbi Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Clinical Research Unit 136, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes 54:3474-83. 2005
    ..Skeletal muscle biopsies, obtained from 18 lipodystrophic nondiabetic patients (LIPO) and 18 nondiabetic patients without lipodystrophy (NONLIPO) before and during hyperinsulinemic (40 mU.m(-2)...
  94. pmc Binding the mammalian high mobility group protein AT-hook 2 to AT-rich deoxyoligonucleotides: enthalpy-entropy compensation
    Suzanne Joynt
    Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA
    Biophys J 96:4144-52. 2009
    b>HMGA2 is a DNA minor-groove binding protein...
  95. ncbi Mutation of the htrB locus of Haemophilus influenzae nontypable strain 2019 is associated with modifications of lipid A and phosphorylation of the lipo-oligosaccharide
    N G Lee
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Biol Chem 270:27151-9. 1995
    ..SDS-polyacrylamide gel electrophoresis analysis revealed that the lipo-oligosaccharide (LOS) isolated from these mutants migrated faster than the wild type LOS and its color changed from ..
  96. ncbi [Intravenous delivery of cationic liposomes conjugation to recombinant adenoviral vectors containing human endostatin gene inhibits ovarian cancer growth in nude mice]
    Li Wang
    Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:190-4. 2009
    ..To evaluate the anticancer effect of liposome plus Ad-Endostatin complex on human ovarian serous cystocarcinoma...
  97. ncbi Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT)
    Tengjiao Cui
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
    J Mol Biol 352:629-45. 2005
    The mammalian high mobility group protein A2 (HMGA2) is a chromosomal architectural transcription factor involved in oncogenesis and cell transformation...
  98. doi Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa
    M Halwani
    The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6
    J Antimicrob Chemother 62:1291-7. 2008
    The aim of this study was to enhance the antimicrobial efficacy of a liposomal gentamicin formulation with gallium metal (Lipo-Ga-GEN) against clinical isolates of Pseudomonas aeruginosa.
  99. ncbi NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 47:971-7. 2008
    Lipomas are frequently characterized by rearrangements resulting in the fusion of the HMGA2 gene (12q14.3) with a variety of partners. Chromosome band 9p22 rearrangements occur in about 1% of lipomas...
  100. ncbi Expression of the early nodulin, ENOD40, in soybean roots in response to various lipo-chitin signal molecules
    E Minami
    Department of Microbiology, University of Tennessee, Knoxville 37996 0845, USA
    Plant J 10:23-32. 1996
    The lipo-chitin (LCO) nodulation signal (nod signal) purified from Bradyrhizobium japonicum induced nodule primordia on soybean (i.e. Glycine soja) roots...

Research Grants92

  1. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    Nils G Walter; Fiscal Year: 2010
    ..to regulate expression of disease-related transcriptional effectors, among them the High Mobility Group AT-hook 2 (HMGA2) protein involved in transcriptional regulation and associated with various cancers as well as diet-induced ..
  2. Targeting the let-7-HMGA2 Network in Metastatic Progression in Pancreatic Cancer
    Linda M S Resar; Fiscal Year: 2013
    ..We are studying the molecular pathways that lead to tumor progression in PDAC. Our focus is the HMGA2 oncogene, which encodes the HMGA2 chromatin remodeling protein...
  3. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    NILS WALTER; Fiscal Year: 2009
    ..to regulate expression of disease-related transcriptional effectors, among them the High Mobility Group AT-hook 2 (HMGA2) protein involved in transcriptional regulation and associated with various cancers as well as diet-induced ..
  4. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    NILS WALTER; Fiscal Year: 2007
    ..to regulate expression of disease-related transcriptional effectors, among them the High Mobility Group AT-hook 2 (HMGA2) protein involved in transcriptional regulation and associated with various cancers as well as diet-induced ..
  5. MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSION
    David Ann; Fiscal Year: 2001
    ..Moreover, the proposed study is of great significance as the dysregulation of this Raf-1 mediated process could lead to cell transformation. ..
  6. MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSION
    David Ann; Fiscal Year: 2000
    ..Moreover, the proposed study is of great significance as the dysregulation of this Raf-1 mediated process could lead to cell transformation. ..
  7. MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSION
    David Ann; Fiscal Year: 2002
    ..Moreover, the proposed study is of great significance as the dysregulation of this Raf-1 mediated process could lead to cell transformation. ..
  8. MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSION
    David Ann; Fiscal Year: 1999
    ..Moreover, the proposed study is of great significance as the dysregulation of this Raf-1 mediated process could lead to cell transformation. ..
  9. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions through sterol-response element binding protein-1c (SREBP-1c) is limited, as is the role of ..
  10. Epithelial JNK-TGFb1 Signaling Axis in Airway Remodeling
    Yvonne M W Janssen-Heininger; Fiscal Year: 2013
    ..Decreases in let-7 miRNA in turn enhances expression of the high mobility group A2 (HMGA2) gene, a proximal regulator of EMT, events that lead to subepithelial collagen deposition...
  11. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2011
    ..b>Lipo- polysaccharide challenge experiments will be conducted in mice in which LRP-1 is conditionally deleted in ..
  12. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2013
    ..b>Lipo- polysaccharide challenge experiments will be conducted in mice in which LRP-1 is conditionally deleted in ..
  13. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2010
    ..undergoes significant adaptive changes, which includes altering the expression of several major outer surface (lipo)proteins...
  14. The Regulation of Stem Cell Aging
    Sean J Morrison; Fiscal Year: 2010
    ..We have discovered that the high mobility group transcriptional regulator, Hmga2, is expressed by fetal and young adult, but not old adult stem cells...
  15. The Regulation of Stem Cell Aging
    Sean J Morrison; Fiscal Year: 2013
    ..We have discovered that the high mobility group transcriptional regulator, Hmga2, is expressed by fetal and young adult, but not old adult stem cells...
  16. Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMR
    Jacob Schaefer; Fiscal Year: 2010
    ..to the biomedically relevant characterization of new types of cyclic antimicrobial peptides, lipodecapeptides and lipo-octapeptides...
  17. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2013
    ..undergoes significant adaptive changes, which includes altering the expression of several major outer surface (lipo)proteins...
  18. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2013
    ..undergoes significant adaptive changes, which includes altering the expression of several major outer surface (lipo)proteins...
  19. Targeting stromal reaction in pancreatic cancer to overcome chemo-resistance
    Hidayatullah G Munshi; Fiscal Year: 2013
    ..of the collagenase membrane type 1-matrix metalloproteinase (MT1-MMP, MMP-14) and high mobility group A2 (HMGA2), an architectural DNA-binding protein involved in regulating chromatin structure...
  20. The role of WNT10B and HMGA2 in Lung Metastasis in Triple Negative Breast Cancer
    GUSTAVO ADOLFO MIRANDA-CARBONI; Fiscal Year: 2013
    ..Wnt10b/b- catenin/HMGA2 signaling has been shown by our group to over-activated in triple-negative breast cancers (TNBC) and basal-like ..
  21. Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMR
    Jacob Schaefer; Fiscal Year: 2013
    ..to the biomedically relevant characterization of new types of cyclic antimicrobial peptides, lipodecapeptides and lipo-octapeptides...
  22. Novel Fas/CD95 Signaling Mechanisms
    Marcus E Peter; Fiscal Year: 2010
    ..expression of the microRNA let-7 and we obtained evidence that let-7 drives tumor progression through targeting HMGA2 and IMP-1...
  23. The Role of MicroRNAs in Tumor Progression
    Marcus E Peter; Fiscal Year: 2010
    ..The early embryonic gene HMGA2 was found to be a prime target of let-7 and was found to be upregulated in tumor cells from advanced ovarian ..
  24. The Role of MicroRNAs in Tumor Progression
    Marcus E Peter; Fiscal Year: 2013
    ..The early embryonic gene HMGA2 was found to be a prime target of let-7 and was found to be upregulated in tumor cells from advanced ovarian ..
  25. The role of PON2 and PON3 proteins in Atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2013
    ..The aryl esterase, organophosphatase, and lipo-lactonase activities of PON enzymes underscore their importance in inflammation, toxicology, and infection, ..
  26. Genetic Studies of Uterine Leiomyomata
    CYNTHIA CASSON MORTON; Fiscal Year: 2013
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGA2 and HMGA1, located on chromosomes 12 and 6, respectively, participate in the pathobiology of uterine leiomyomata, ..
  27. Genetic Studies of Uterine Leiomyomata
    CYNTHIA CASSON MORTON; Fiscal Year: 2010
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGA2 and HMGA1, located on chromosomes 12 and 6, respectively, participate in the pathobiology of uterine leiomyomata, ..
  28. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2010
    ..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
  29. Structure and Function of Treponema pallidum Lipoproteins
    Michael V Norgard; Fiscal Year: 2013
    ..seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo) proteins of the organism. These membrane proteins likely play strategic roles in sustaining T...
  30. Biosynthesis of Antifungal Lipopeptides from Filamentous Fungi
    Yi Tang; Fiscal Year: 2013
    ..Newly approved lipo-NRPs such as daptomycin and anidulafungin (a semisynthetic derivative of echinocandin B, the target of this ..
  31. Functional Characterization of Lung Adenocarcinoma Progression and Metastasis
    MONTE MEIER WINSLOW; Fiscal Year: 2010
    ..the function of candidate genes in an autochthonous lung adenocarcinoma mouse model;(3) Determine the effect of Hmga2 loss on tumor progression and metastasis...
  32. Functional Characterization of Hmga2 in Lung Cancer Progression
    MONTE MEIER WINSLOW; Fiscal Year: 2013
    ..genes to lung adenocarcinoma progression;(2) Interrogate the function of candidate genes in an autochthonous lung adenocarcinoma mouse model;(3) Determine the effect of Hmga2 loss on tumor progression and metastasis.
  33. Functional Characterization of Lung Adenocarcinoma Progression and Metastasis
    MONTE MEIER WINSLOW; Fiscal Year: 2012
    ..genes to lung adenocarcinoma progression;(2) Interrogate the function of candidate genes in an autochthonous lung adenocarcinoma mouse model;(3) Determine the effect of Hmga2 loss on tumor progression and metastasis.
  34. Genetic studies of familial multiple lipomatosis
    JOHN PHILLIPS III; Fiscal Year: 2001
    ..We will determine the functional importance of and the mechanisms by which these mutations cause familial lipomatosis. ..
  35. Genetic studies of familial multiple lipomatosis
    JOHN PHILLIPS III; Fiscal Year: 2002
    ..We will determine the functional importance of and the mechanisms by which these mutations cause familial lipomatosis. ..
  36. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    KAMAL MEHTA; Fiscal Year: 2009
    ..Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions through sterol-response element binding protein-1c (SREBP-1c) is limited, as is the role of ..
  37. HORMONAL CONTROL OF ADIPOSE TISSUE LIPOPROTEIN LIPASE
    Robert Eckel; Fiscal Year: 1980
    ..This will not only further our understanding of physiologic control mechanisms, but allow the ability to correct defects in adipose tissue lipo-protein lipase found in human disease such as insulin deficient diabetes mellitus.
  38. The Regulation of Stem Cell Aging
    SEAN MORRISON; Fiscal Year: 2009
    ..We have discovered that the high mobility group transcriptional regulator, Hmga2, is expressed by fetal and young adult, but not old adult stem cells...
  39. Structure and Function of Treponema pallidum Lipoproteins
    Michael V Norgard; Fiscal Year: 2010
    ..seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo) proteins of the organism. These membrane proteins likely play strategic roles in sustaining T...
  40. Structure and Function of Treponema pallidum Lipoproteins
    MICHAEL NORGARD; Fiscal Year: 2009
    ..seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo) proteins of the organism. These membrane proteins likely play strategic roles in sustaining T...
  41. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2010
    ..b>Lipo- polysaccharide challenge experiments will be conducted in mice in which LRP-1 is conditionally deleted in ..
  42. MECHANISM OF PAF INDUCED LUNG INJURY
    Hoyte van der Zee; Fiscal Year: 1990
    ..by 1) activated platelets and/or leukocytes singularly or synergistically; 2) by products of the cyclo- and lipo-oxygenase pathway or arachidonic acid metabolism...
  43. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2007
    ..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
  44. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2009
    ..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
  45. Polymer-Based Yersinia Pestis Point-of-Case Diagnostics
    Jean Clarke; Fiscal Year: 2003
    ..amplification of fluorescence transduction events to rapidly identify species-specific genomic, proteomic, and lipo-oligosaccharide (LOS) markers of Y. pestis...
  46. Polymer-Based Yersinia Pestis Point-of-Case Diagnostics
    Jean Clarke; Fiscal Year: 2004
    ..amplification of fluorescence transduction events to rapidly identify species-specific genomic, proteomic, and lipo-oligosaccharide (LOS) markers of Y. pestis...
  47. MODIFIED-LDL REGULATES MACROPHAGE PLASMINOGEN ACTIVATION
    DOMENICK FALCONE; Fiscal Year: 1990
    ..For these purposes, we will study lipo-protein metabolism by macrophage populations induced in vivo with eliciting and activating agents, and cells ..
  48. MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATA
    Cynthia Morton; Fiscal Year: 2000
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGIC and HMGlY, located on chromosomes 12 and 6, respectively participate in the pathobiology of uterine leiomyomata...
  49. MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATA
    Cynthia Morton; Fiscal Year: 2001
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGIC and HMGlY, located on chromosomes 12 and 6, respectively participate in the pathobiology of uterine leiomyomata...
  50. MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATA
    Cynthia Morton; Fiscal Year: 2002
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGIC and HMGlY, located on chromosomes 12 and 6, respectively participate in the pathobiology of uterine leiomyomata...
  51. MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATA
    Cynthia Morton; Fiscal Year: 1999
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGIC and HMGlY, located on chromosomes 12 and 6, respectively participate in the pathobiology of uterine leiomyomata...
  52. APOLIPOPROTEIN B: GENETICS AND HYPERCHOLESTEROLEMIA
    BRIAN MC CARTHY; Fiscal Year: 1990
    ..The genomes of patients with defective low density lipo-protein will be screened for mutations leading to changes in the receptor binding domain of apo-B100 or to abnormal ..
  53. Saw Palmetto, Cyclooxygenase, and Prostate Cancer
    CHARLES ROSELLI; Fiscal Year: 2006
    ..The lipo-sterolic extract of saw palmetto (SPE) has been shown to be as effective as finasteride in the treatment of urinary ..
  54. CLONING OF A LEIOMYOMA ASSOCIATED GENE ON CHROMOSOME 14
    Bradley Quade; Fiscal Year: 1999
    ..Quade ample opportunities to interact with experienced molecular geneticists as he completes his training. ..
  55. Saw Palmetto, Cyclooxygenase, and Prostate Cancer
    CHARLES ROSELLI; Fiscal Year: 2007
    ..The lipo-sterolic extract of saw palmetto (SPE) has been shown to be as effective as finasteride in the treatment of urinary ..
  56. SEX STEROIDS, OBESITY AND LIPIDS IN ADOLESCENT FEMALES
    Anne Lucky; Fiscal Year: 1990
    ..sex steroid hormones and obesity, and their interactions with lipoprotein cholesterol and apolipoprotein (lipo/apo) levels in 9 and 10 year old black and white adolescent females longitudinally for five years during puberty...
  57. Saw Palmetto, Cyclooxygenase, and Prostate Cancer
    CHARLES ROSELLI; Fiscal Year: 2006
    ..The lipo-sterolic extract of saw palmetto (SPE) has been shown to be as effective as finasteride in the treatment of urinary ..
  58. ASSEMBLY OF CEREBRAL MYELIN MEMBRANES
    FIROZE JUNGALWALA; Fiscal Year: 1980
    ..and/or exchange of newly synthesized lipids from endoplasmic reticulum (microsomes) to myelin can occur with lipo-protein carriers as intermediates...
  59. Metabotropic glutamate receptors in the vagal processing of taste information
    ROBERT HALLOCK; Fiscal Year: 2007
    ..Second, mGluR agonists have recently been shown to decrease lipo-polysaccharide induced anorexia...
  60. ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMA
    Cheryl Walker; Fiscal Year: 2006
    ..abstract_text> ..
  61. ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMA
    Cheryl Walker; Fiscal Year: 2002
    ..abstract_text> ..
  62. ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMA
    Cheryl Walker; Fiscal Year: 2005
    ..abstract_text> ..
  63. ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMA
    Cheryl Walker; Fiscal Year: 2003
    ..abstract_text> ..
  64. ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMA
    Cheryl Walker; Fiscal Year: 2003
    ..abstract_text> ..
  65. ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMA
    Cheryl Walker; Fiscal Year: 2004
    ..abstract_text> ..
  66. LIPID GROWTH FACTOR FOR NORMAL AND MALIGNANT B CELLS
    Ulrich Hammerling; Fiscal Year: 1991
    We have identified a lipo-protein complex with growth-promoting properties in supernates of human lymphoblastoid cell lines and activated normal B cells. The protein moiety is prealbumin which originates from the culture medium...
  67. LIPID GROWTH FACTOR FOR NORMAL AND MALIGNANT B CELLS
    Ulrich Hammerling; Fiscal Year: 1990
    We have identified a lipo-protein complex with growth-promoting properties in supernates of human lymphoblastoid cell lines and activated normal B cells. The protein moiety is prealbumin which originates from the culture medium...
  68. LIPID GROWTH FACTOR FOR NORMAL AND MALIGNANT B CELLS
    Ulrich Hammerling; Fiscal Year: 1993
    We have identified a lipo-protein complex with growth-promoting properties in supernates of human lymphoblastoid cell lines and activated normal B cells. The protein moiety is prealbumin which originates from the culture medium...
  69. LIPID GROWTH FACTOR FOR NORMAL AND MALIGNANT B CELLS
    Ulrich Hammerling; Fiscal Year: 1992
    We have identified a lipo-protein complex with growth-promoting properties in supernates of human lymphoblastoid cell lines and activated normal B cells. The protein moiety is prealbumin which originates from the culture medium...
  70. PHYSICAL AND METABOLIC ABNORMALITIES OF LIPODYSTROPHY
    Abhimanyu Garg; Fiscal Year: 2000
    ..Furthermore, the study will determine the natural course of the disease in patients with lipo- dystrophies through clinical and laboratory investigations...
  71. VALIDATION OF HMGI-C AS A DRUG TARGET IN OBESITY
    ROLAND CHOUINARD; Fiscal Year: 2001
    ..It is estimated that the U.S. mark for a prescription anti-obesity drug is approximately $ 1 billion in annual sales. For an over-the-counter drug, potential market is believed to be $10 billion. ..
  72. VALIDATION OF HMGI-C AS A DRUG TARGET IN OBESITY
    ROLAND CHOUINARD; Fiscal Year: 2000
    ..It is estimated that the U.S. mark for a prescription anti-obesity drug is approximately $ 1 billion in annual sales. For an over-the-counter drug, potential market is believed to be $10 billion. ..
  73. The Role of MicroRNAs in Tumor Progression
    Marcus E Peter; Fiscal Year: 2010
    ..The early embryonic gene HMGA2 was found to be a prime target of let-7 and was found to be upregulated in tumor cells from advanced ovarian ..
  74. Novel Fas/CD95 Signaling Mechanisms
    Marcus Peter; Fiscal Year: 2009
    ..expression of the microRNA let-7 and we obtained evidence that let-7 drives tumor progression through targeting HMGA2 and IMP-1...
  75. Validation of HMGI-C as a Drug Target in Colon Cancer
    ROLAND CHOUINARD; Fiscal Year: 2002
    ..It is now estimated that in the United States alone, 129,400 new cases of colon cancer were reported, indicating the demand for safe, reliable pharmaceuticals. ..
  76. EPIDEMIOLOGY OF APO- & LIPO-PROTEINS IN ELDERLY WOMEN
    Jane Cauley; Fiscal Year: 1991
    ..of apoprotein A-IV and E and to determine whether these polymorphisms are associated with specific patterns of lipo and apoproteins; and 4...
  77. EPIDEMIOLOGY OF APO- & LIPO-PROTEINS IN ELDERLY WOMEN
    Jane Cauley; Fiscal Year: 1992
    ..of apoprotein A-IV and E and to determine whether these polymorphisms are associated with specific patterns of lipo and apoproteins; and 4...