HMGA2

Summary

Gene Symbol: HMGA2
Description: high mobility group AT-hook 2
Alias: BABL, HMGI-C, HMGIC, LIPO, STQTL9, High-mobility group protein HMGI-C, high mobility group AT-hook protein 2, high mobility group protein HMGI-C, high-mobility group (nonhistone chromosomal) protein isoform I-C
Species: human

Top Publications

  1. ncbi Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
    Demetris Pillas
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 6:e1000856. 2010
  2. ncbi HMGA2 participates in transformation in human lung cancer
    Francescopaolo Di Cello
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 6:743-50. 2008
  3. ncbi HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB
    Isabelle Cleynen
    Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Herestraat 49, Box 602, B 3000 Leuven, Belgium
    Mol Cancer Res 5:363-72. 2007
  4. ncbi Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    Christine Mayr
    Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 315:1576-9. 2007
  5. ncbi HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
    Heike Summer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:4371-84. 2009
  6. ncbi Identification of novel HMGA2 fusion sequences in lipoma: evidence that deletion of let-7 miRNA consensus binding site 1 in the HMGA2 3' UTR is not critical for HMGA2 transcriptional upregulation
    Xiaoke Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 48:673-8. 2009
  7. ncbi HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
  8. ncbi The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
    Yong Sun Lee
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 21:1025-30. 2007
  9. ncbi High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Genesis 44:523-9. 2006
  10. ncbi DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    FEBS Lett 581:3533-7. 2007

Research Grants

  1. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    NILS WALTER; Fiscal Year: 2007
  2. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    Nils G Walter; Fiscal Year: 2010
  3. MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSION
    David Ann; Fiscal Year: 2002
  4. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2010
  5. Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMR
    Jacob Schaefer; Fiscal Year: 2010
  6. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
  7. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    KAMAL MEHTA; Fiscal Year: 2009
  8. Genetic Studies of Uterine Leiomyomata
    CYNTHIA CASSON MORTON; Fiscal Year: 2010
  9. Structure and Function of Treponema pallidum Lipoproteins
    MICHAEL NORGARD; Fiscal Year: 2009
  10. Structure and Function of Treponema pallidum Lipoproteins
    Michael V Norgard; Fiscal Year: 2010

Detail Information

Publications186 found, 100 shown here

  1. ncbi Genome-wide association study reveals multiple loci associated with primary tooth development during infancy
    Demetris Pillas
    Department of Epidemiology and Public Health, Imperial College London, London, United Kingdom
    PLoS Genet 6:e1000856. 2010
    ..loci included several genes with links to tooth and other organ development (KCNJ2, EDA, HOXB2, RAD51L1, IGF2BP1, HMGA2, MSRB3). Genes at four of the identified loci are implicated in the development of cancer...
  2. ncbi HMGA2 participates in transformation in human lung cancer
    Francescopaolo Di Cello
    Hematology Division, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mol Cancer Res 6:743-50. 2008
    ..studies have established a prominent role for HMGA1 (formerly HMG-I/Y) in aggressive human cancers, the role of HMGA2 (formerly HMGI-C) in malignant transformation has not been clearly defined...
  3. ncbi HMGA2 regulates transcription of the Imp2 gene via an intronic regulatory element in cooperation with nuclear factor-kappaB
    Isabelle Cleynen
    Department of Human Genetics, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Herestraat 49, Box 602, B 3000 Leuven, Belgium
    Mol Cancer Res 5:363-72. 2007
    ..We recently identified the Imp2 gene as a target gene of the architectural transcription factor HMGA2 (high mobility group A2) and its tumor-specific truncated form HMGA2Tr...
  4. ncbi Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    Christine Mayr
    Howard Hughes Medical Institute and Department of Biology, Massachusetts Institute of Technology, and Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
    Science 315:1576-9. 2007
    ..chromosomal translocations previously associated with human tumors disrupt repression of High Mobility Group A2 (Hmga2) by let-7 miRNA...
  5. ncbi HMGA2 exhibits dRP/AP site cleavage activity and protects cancer cells from DNA-damage-induced cytotoxicity during chemotherapy
    Heike Summer
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Nucleic Acids Res 37:4371-84. 2009
    ..Intriguingly, HMGA2 is also found in rare tumor-inducing cells which are resistant to chemotherapy...
  6. ncbi Identification of novel HMGA2 fusion sequences in lipoma: evidence that deletion of let-7 miRNA consensus binding site 1 in the HMGA2 3' UTR is not critical for HMGA2 transcriptional upregulation
    Xiaoke Wang
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 48:673-8. 2009
    ..Rearrangement of HMGA2 in chromosome band 12q15 has been found in approximately 60-70% of ordinary lipomas with cytogenetic abnormalities...
  7. ncbi HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..In addition, using quantitative RT-PCR we studied the expression of MDM2, CDK4, DDIT3 (CHOP/GADD153), DYRK2, HMGA2, TSPAN31 and YEATS4 (GAS41) in 11 cases. We showed that CDK4 (12q14...
  8. ncbi The tumor suppressor microRNA let-7 represses the HMGA2 oncogene
    Yong Sun Lee
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, USA
    Genes Dev 21:1025-30. 2007
    b>HMGA2, a high-mobility group protein, is oncogenic in a variety of tumors, including benign mesenchymal tumors and lung cancers...
  9. ncbi High-level expression of DNA architectural factor HMGA2 and its association with nucleosomes in human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, Singapore
    Genesis 44:523-9. 2006
    ..The non-histone chromatin-associated factor HMGA2 has been studied mostly in the mouse where its function seems critical for embryonic cell growth and adipocytic ..
  10. ncbi DNA architectural factor and proto-oncogene HMGA2 regulates key developmental genes in pluripotent human embryonic stem cells
    Ou Li
    Division of Genomics and Genetics, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    FEBS Lett 581:3533-7. 2007
    ..We showed recently that among the major HMG proteins, HMGA2 is highly expressed in two human embryonic stem (hES) cell lines...
  11. ncbi cDNA cloning of the HMGI-C phosphoprotein, a nuclear protein associated with neoplastic and undifferentiated phenotypes
    G Manfioletti
    Universita di Trieste, Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Italy
    Nucleic Acids Res 19:6793-7. 1991
    ..Analysis of mRNA levels demonstrate that the HMGI-C gene is not expressed in a variety of mouse tissues but is expressed in Lewis lung carcinoma cells...
  12. ncbi Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas
    Anna Dahlén
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Mod Pathol 16:1132-40. 2003
    ..The HMGA2 (HMGI-C) locus in 12q15 is frequently rearranged in other benign mesenchymal tumors, and this study aimed at ..
  13. ncbi Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..genes in Hedgehog signaling (IHH, HHIP, PTCH1), extracellular matrix (EFEMP1, ADAMTSL3, ACAN) and cancer (CDK6, HMGA2, DLEU7) pathways, and provide new insights into human growth and developmental processes...
  14. ncbi Identification of ten loci associated with height highlights new biological pathways in human growth
    Guillaume Lettre
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:584-91. 2008
    ..These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait...
  15. ncbi High mobility group A2 potentiates genotoxic stress in part through the modulation of basal and DNA damage-dependent phosphatidylinositol 3-kinase-related protein kinase activation
    Lee Ming Boo
    Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, California 90033 1049, USA
    Cancer Res 65:6622-30. 2005
    The high mobility group A2 (HMGA2) protein belongs to the architectural transcription factor HMGA family, playing a role in chromosomal organization and transcriptional regulation...
  16. ncbi Genomic characterization of human HMGIC, a member of the accessory transcription factor family found at translocation breakpoints in lipomas
    H R Ashar
    Department of Biochemistry, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    Genomics 31:207-14. 1996
    b>HMGIC, a member of the HMGI family of high mobility group proteins, is disrupted in 3/3 lipomas characterized by 12q14-q15 rearrangements...
  17. ncbi HMGI/Y proteins: flexible regulators of transcription and chromatin structure
    R Reeves
    Department of Biochemistry Biophysics, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
    Biochim Biophys Acta 1519:13-29. 2001
    ....
  18. ncbi The HMGA proteins: a myriad of functions (Review)
    Isabelle Cleynen
    Laboratory of Molecular Oncology, Department of Human Genetics, University of Leuven, Herestraat 49 bus 602, Leuven, Belgium
    Int J Oncol 32:289-305. 2008
    ..members: HMGA1a, HMGA1b and HMGA1c, which result from translation of alternative spliced forms of one gene and HMGA2, which is encoded for by another gene...
  19. ncbi Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15)
    Inga von Ahsen
    Center of Human Genetics, University of Bremen, Germany
    Cancer Genet Cytogenet 163:68-70. 2005
    ..t(3;12)(q27 approximately 28; q14 approximately 15) in lipomas and pulmonary chondroid hamartomas (PCHs) makes the HMGA2-LPP fusion gene the most frequent fusion gene in human tumors...
  20. ncbi Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2
    Sun Mi Park
    The Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Cell Cycle 6:2585-90. 2007
    ..expression of a number of genes such as c-myc and RAS as well as the embryonic gene high mobility group, A2 (HMGA2). We now demonstrate that HMGA2 is more efficiently targeted by let-7 than RAS...
  21. ncbi Expression of mesenchyme-specific gene HMGA2 in squamous cell carcinomas of the oral cavity
    Jun Miyazawa
    Department of Oral and Maxillofacial Surgery, Nippon Dental University, 1 9 20 Fujimi, Chiyoda ku, Tokyo 102 8159, Japan
    Cancer Res 64:2024-9. 2004
    ..b>HMGA2 is an architectural transcriptional factor that is expressed in the undifferentiated mesenchyme and initiates ..
  22. ncbi A common variant of HMGA2 is associated with adult and childhood height in the general population
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 39:1245-50. 2007
    ..Common variants in the HMGA2 oncogene, exemplified by rs1042725, were associated with height (P = 4 x 10(-8))...
  23. ncbi HMGA2 induces pituitary tumorigenesis by enhancing E2F1 activity
    Monica Fedele
    Istituto di Endocrinologia ed Oncologia Sperimentale del CNR and Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita di Napoli Federico II, 80131 Naples, Italy
    Cancer Cell 9:459-71. 2006
    b>HMGA2 gene amplification and overexpression in human prolactinomas and the development of pituitary adenomas in HMGA2 transgenic mice showed that HMGA2 plays a crucial role in pituitary tumorigenesis...
  24. ncbi HMGA2 is expressed in an allele-specific manner in human lipomas
    Hena R Ashar
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ 08854, USA
    Cancer Genet Cytogenet 143:160-8. 2003
    The architectural transcription factor HMGA2 is almost exclusively expressed in undifferentiated mesenchymal cells...
  25. ncbi An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue
    N Abe
    First Department of Surgery, Kyorin University School of Medicine, 6 20 2, Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Br J Cancer 89:2104-9. 2003
    The altered form of the high-mobility group A2 (HMGA2) gene is somehow related to the generation of human benign and malignant tumours of mesenchymal origin...
  26. ncbi High mobility group A2 protein and its derivatives bind a specific region of the promoter of DNA repair gene ERCC1 and modulate its activity
    Lars Borrmann
    Center for Human Genetics, University of Bremen, Leobenerstr ZHG, D 28359 Bremen, Germany
    Nucleic Acids Res 31:6841-51. 2003
    High mobility group A2 (HMGA2) chromosomal non-histone protein and its derivatives play an important role in development and progression of benign and malignant tumors, obesity and arteriosclerosis, although the underlying mechanisms of ..
  27. ncbi High mobility group A2 is a target for miRNA-98 in head and neck squamous cell carcinoma
    Carla Hebert
    Diagnostic Sciences and Pathology, University of Maryland Baltimore, Baltimore, Maryland 21201 1586, USA
    Mol Cancer 6:5. 2007
    b>HMGA2 expression has been shown to be associated with enhanced selective chemosensitivity towards the topoisomerase (topo) II inhibitor, doxorubicin, in cancer cells...
  28. ncbi HMGA2 overexpression in non-small cell lung cancer
    Britta Meyer
    Centre for Human Genetics, University of Bremen, Bremen, Germany
    Mol Carcinog 46:503-11. 2007
    ..Overexpression of the high mobility group protein HMGA2 has been observed in a variety of malignant tumors and often correlates with poor prognosis...
  29. ncbi Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours
    E F Schoenmakers
    Laboratory for Molecular Oncology, University of Leuven, Belgium
    Nat Genet 10:436-44. 1995
    ..These results suggest a link between a member of the HMG gene family and benign solid tumour development...
  30. ncbi HMGIC expression in human adult and fetal tissues and in uterine leiomyomata
    G J Gattas
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Genes Chromosomes Cancer 25:316-22. 1999
    The high-mobility-group (HMG) protein gene, HMGIC, is localized to chromosome 12, band q15, a region often rearranged in benign mesenchymal tumors, including uterine leiomyomata...
  31. ncbi Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains
    H R Ashar
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    Cell 82:57-65. 1995
    ..These results, identifying a gene rearranged in a benign neoplastic process that does not proceed to a malignancy, suggest a role for HMGI-C in adipogenesis and mesenchyme differentiation...
  32. ncbi Common variants in the GDF5-UQCC region are associated with variation in human height
    Serena Sanna
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:198-203. 2008
    ..reproducibly associated with height in mendelian syndromes, and common variants in the transcription factor gene HMGA2 are associated with variation in height in the general population...
  33. ncbi Truncation and fusion of HMGA2 in lipomas with rearrangements of 5q32-->q33 and 12q14-->q15
    M Nilsson
    Department of Clinical Genetics, University Hospital, Lund, Sweden
    Cytogenet Genome Res 112:60-6. 2006
    ..The HMGA2 gene is often rearranged, but little is known about the molecular consequences at other breakpoints...
  34. ncbi Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion
    J I da Motta
    Department of Pharmacology, , Brazil
    Br J Pharmacol 112:111-6. 1994
    ..antagonist (BN 50730), a cyclo-oxygenase inhibitor (indomethacin), a lipoxygenase inhibitor (MK-886), a dual type lipo- and cyclo-oxygenase inhibitor (NDGA), a bradykinin antagonist (Hoe 140) or the combination of cetirizine, MK-886, ..
  35. ncbi HMGA proteins in malignant peripheral nerve sheath tumor and synovial sarcoma: preferential expression of HMGA2 in malignant peripheral nerve sheath tumor
    Pei Hui
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8023, USA
    Mod Pathol 18:1519-26. 2005
    ..To this end, we explored diagnostic applications of HMGA (HMGA1 and HMGA2) protein immunohistochemistry in comparable groups of synovial sarcoma and malignant peripheral nerve sheath ..
  36. ncbi Targeting and assembly of an oligomeric bacterial enterotoxoid in the endoplasmic reticulum of Saccharomyces cerevisiae
    O Schonberger
    Department of Molecular Biology, Hebrew University, Hadassah Medical School, Jerusalem, Israel
    Mol Microbiol 5:2663-71. 1991
    ..coli lipoprotein signal sequence attached to the mature sequence of the B subunit of heat-labile enterotoxin (Lipo-EtxB) was expressed in yeast and E. coli. Analyses of cell lysates from Saccharomyces cerevisiae and E...
  37. ncbi Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function
    Deborah S Hunter
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville, Texas 78957, USA
    Cancer Res 62:3766-72. 2002
    ..Concomitantly, HMGA2 protein, which was completely absent in normal myometria, was expressed in 16 of 19 Eker leiomyomas...
  38. ncbi HMGA1 and HMGA2 protein expression in mouse spermatogenesis
    Paolo Chieffi
    Dipartimento di Medicina Sperimentale, II Universita di Napoli, Via Costantinopoli 16, 80138 Naples, Italy
    Oncogene 21:3644-50. 2002
    The high-mobility group A (HMGA) nonhistone chromosomal proteins HMGA1 and HMGA2 play a role in determining chromatin structure and in regulating the transcription of several genes...
  39. ncbi Thyroid cell transformation requires the expression of the HMGA1 proteins
    Maria Teresa Berlingieri
    Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche c o Dipartimento di Patologia Cellulare e Molecolare, Facolta di Medicina e Chirurgia, Universita Degli Studi Di Napoli, Via Pansini 5, 80131 Naples, Italy
    Oncogene 21:2971-80. 2002
    Elevated expression of HMGA1 and HMGA2 proteins is correlated with a highly malignant phenotype in several human tumors...
  40. ncbi Fusion of HMGA2 to COG5 in uterine leiomyoma
    Gopalrao V N Velagaleti
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55906, USA
    Cancer Genet Cytogenet 202:11-6. 2010
    ..Approximately 10% of these tumors contain rearrangements of the chromatin-remodeling gene HMGA2 at the chromosome band 12q14.3. Herein, we report on a uterine leiomyoma with a novel HMGA2 fusion gene...
  41. ncbi High-mobility group protein HMGA2-derived fragments stimulate the proliferation of chondrocytes and adipose tissue-derived stem cells
    A Richter
    Centre for Human Genetics, University of Bremen, Bremen, Germany
    Eur Cell Mater 21:355-63. 2011
    In previous research, it was shown that recombinant HMGA2 protein enhances the proliferation of porcine chondrocytes grown in vitro, opening up promising applications of this embryonic architectural transcription factor for tissue ..
  42. ncbi Let-7 microRNA and HMGA2 levels of expression are not inversely linked in adipocytic tumors: analysis of 56 lipomas and liposarcomas with molecular cytogenetic data
    Laurence Bianchini
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 50:442-55. 2011
    The aim of our study was first to assess the role of HMGA2 expression in the pathogenesis of adipocytic tumors (AT) and, second, to seek a potential correlation between overexpression of HMGA2 and let-7 expression inhibition by analyzing ..
  43. ncbi Transcriptional regulation by targeted expression of architectural transcription factor high mobility group A2 in salivary glands of transgenic mice
    H Helen Lin
    Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles, CA, USA
    Eur J Oral Sci 115:30-9. 2007
    High mobility group A2 (HMGA2) protein is a non-histone architectural transcription factor...
  44. ncbi SUMOylation of HMGA2: selective destabilization of promyelocytic leukemia protein via proteasome
    Xuefei Cao
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA
    Mol Cancer Ther 7:923-34. 2008
    The HMGA2 architectural protein functions in a variety of cellular processes, such as cell growth, transcription regulation, neoplastic transformation, and progression...
  45. ncbi Odontogenic myxofibroma with HMGA2 overexpression and HMGA2 rearrangement
    Katsuaki Sato
    Department of Pathology II, Kanazawa Medical University, Ishikawa, Japan
    Pathol Int 60:760-4. 2010
    ..This report describes the first case of an odontogenic myxofibroma presenting with HMGA2 protein overexpression and HMGA2 rearrangement in a 40-year-old woman. A 2...
  46. ncbi Genomic structure and expression of the murine Hmgi-c gene
    X Zhou
    Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854, USA
    Nucleic Acids Res 24:4071-7. 1996
    ..Since the human homolog is disrupted in a number of tumors, HMGI-C could play an important role in cell proliferation and differentiation during mammalian development...
  47. ncbi Isolation and characterization of the gene coding for murine high-mobility-group protein HMGI-C
    G Manfioletti
    Dipartimento di Biochimica, Biofisica e Chimica delle Macromolecole, Universita di Trieste, Italy
    Gene 167:249-53. 1995
    ..A highly homologous pseudogene is also present in the mouse genome. Our results on Hmgi-c structure provide basic information to carry out further studies on the regulation of its expression...
  48. ncbi Truncated and chimeric HMGI-C genes induce neoplastic transformation of NIH3T3 murine fibroblasts
    M Fedele
    Istituto Nazionale dei Tumori di Napoli, Fondazione Senatore Pascale, Naples, Italy
    Oncogene 17:413-8. 1998
    ..The unrearranged wild-type HMGI-C cDNA did not exert any transforming activity. These findings indicate that rearranged forms of HMGI-C play a role in cell transformation...
  49. ncbi Value and limitation of immunohistochemical expression of HMGA2 in mesenchymal tumors: about a series of 1052 cases
    Nadège Dreux
    Department of Pathology, Institut Bergonie, 229 Cours de l Argonne, Bordeaux Cedex, France
    Mod Pathol 23:1657-66. 2010
    The high mobility group A (HMGA2) gene encodes a protein that alters chromatin structure and regulates the transcription of many genes; it is implicated in both benign and malignant neoplasias, but its rearrangements are a feature of ..
  50. ncbi [Expression of regulatory T cells and related cytokines in mice allogenic corneal transplantation rejection]
    Xin Wang
    Department of Ophthalmology, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China
    Zhonghua Yan Ke Za Zhi 45:1118-26. 2009
    ..To study the changes of CD4(+)CD25(+) and CD8(+)CD103(+) regulatory T cells and their relevant cytokines in corneal allograft transplantation in mice...
  51. ncbi Uric acid enhances T cell immune responses to hepatitis B surface antigen-pulsed-dendritic cells in mice
    Xiao Jun Ma
    Department of Infectious Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 13:1060-6. 2007
    ..To study the induction of T cellular immune responses in BALB/c mice immunized with uric acid and dendritic cells (DCs) pulsed with hepatitis B virus surface antigen (HBsAg)...
  52. ncbi Current data on ATP-containing liposomes and potential prospects to enhance cellular energy status for hepatic applications
    V Korb
    AGEPS, APHP, Faculté des Sciences Pharmaceutiques et Biologiques Paris Descartes, Paris, F 75006 France
    Crit Rev Ther Drug Carrier Syst 25:305-45. 2008
    ..Second, studies conducted with ATP liposomally entrapped (lipo-ATP) are described, including pharmaco-technical formulation engineering and related models of assessment...
  53. ncbi Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis
    Hermann Josef Grone
    Department of Cellular and Molecular Pathology, German Cancer Research Center DKFZ, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Lab Invest 82:5-14. 2002
    ..suggests that factors that contribute to the development of atherosclerosis, ie, oxidatively modified (lipo)proteins, may also participate in glomerular injury...
  54. ncbi Differential expression of HMGA1 and HMGA2 in dermatofibroma and dermatofibrosarcoma protuberans: potential diagnostic applications, and comparison with histologic findings, CD34, and factor XIIIa immunoreactivity
    Ning Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06504 8900, USA
    Am J Dermatopathol 26:267-72. 2004
    ..CD34 and Factor XIIIa staining is commonly used in separating DF from DFSP, but is not always helpful. HMGA1 and HMGA2 genes, members of the high mobility group protein family genes, encode proteins that act as architectural ..
  55. ncbi Bezafibrate affects lipid, lipo- and apolipoprotein pattern in non-insulin-dependent diabetic patients
    G Niort
    Istituto di Medicina Interna, University of Torino, Italy
    Horm Metab Res 25:372-4. 1993
    ..Bezafibrate use was safe and improved the lipid pattern and the apolipoprotein and lipid distribution in the lipoproteins, producing a less atherogenic pattern in our NID diabetics...
  56. ncbi Specific beta-lactam antibiotics inhibit secretion of lipo-beta-lactamase in yeast
    A London
    Department of Molecular Biology, Hebrew University-Hadassah Medical School, Jerusalem, Israel
    Mol Microbiol 4:2193-200. 1990
    The beta-lactam antibiotic cloxacillin can inhibit secretion of prokaryotic lipo-beta-lactamase into the periplasm of yeast...
  57. ncbi The high mobility group protein HMGA2: a co-regulator of chromatin structure and pluripotency in stem cells?
    Kurt Pfannkuche
    Institute for Neurophysiology, University of Cologne, Robert Koch Str 39, 50931, Cologne, Germany
    Stem Cell Rev 5:224-30. 2009
    ..For example, HMGA2 is involved in transcriptional activation of certain cell proliferation genes, which likely contributes to its ..
  58. ncbi MR imaging of the lymphatic system in patients with lipedema and lipo-lymphedema
    Christian Lohrmann
    Department of Radiology, University Hospital of Freiburg, Hugstetter Strasse 55, D 79106, Freiburg i Br, Germany
    Microvasc Res 77:335-9. 2009
    To assess for the first time the morphology of the lymphatic system in patients with lipedema and lipo-lymphedema of the lower extremities by MR lymphangiography.
  59. ncbi [Pulmonary complications in patients with AIDS]
    Shinichi Oka
    AIDS Clinical Center, International Medical Center of Japan, 1 21 1, Toyama, Shinjuku ku, Tokyo 162 8655, Japan
    Kekkaku 77:37-40. 2002
    ..LDS was first reported as re-distribution of lipid such as central obesity with or without lipo-atrophy from extremities and/or face...
  60. ncbi Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion
    Takashi Yamamoto
    Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    Cell Tissue Res 332:245-56. 2008
    ..of Kupffer cells after their elimination by administration of liposome-entrapped dichloromethylene diphosphonate (lipo-MDP)...
  61. ncbi Refinement of the 12q14 microdeletion syndrome: primordial dwarfism and developmental delay with or without osteopoikilosis
    Francesca Mari
    Centre for Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, Germany
    Eur J Hum Genet 17:1141-7. 2009
    ..Among the deleted genes, HMGA2 is of particular interest in relationship to the aberrant somatic growth in our patient, as HMGA2 variants have ..
  62. ncbi [Effects of alprostadil in prevention of portal vein thrombogenesis after splenectomy and devascularization: a clinical observation of 76 patients with portal hypertension]
    Jian Cang Ma
    Department of General Surgery, Second Affiliated Hospital of Xi an Jiaotong University, Xi an 710004, China
    Zhonghua Yi Xue Za Zhi 88:524-6. 2008
    To investigate the effects of alprostadil (Lipo PGE1) in prevention of portal vein thrombogenesis (PVT) after splenectomy for portal hypertension.
  63. ncbi Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity
    Eduardo N Taboada
    Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, K1A 0R6, Canada
    BMC Genomics 8:359. 2007
    ..Although sialylated ganglioside-mimicking lipo-oligosaccharide (LOS) structures are the strongest neuropathogenic determinants in C...
  64. ncbi Regulatory expression of genes related to metastasis by TGF-beta and activin A in B16 murine melanoma cells
    Masaru Murakami
    Laboratory of Molecular Biology, Azabu University School of Veterinary Medicine, Sagamihara, Japan
    Mol Biol Rep 37:1279-86. 2010
    ..In epithelial cells, TGF-beta-induced high mobility group A2 (HMGA2) gene product is suggested to down-regulate E-cadherin through up-regulation of zinc-finger transcription factors ..
  65. ncbi The association of lipodystrophy and oxidative stress biomarkers in HIV-infected men
    Helena S Vassimon
    Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Curr HIV Res 8:364-9. 2010
    ..In a cross-sectional study of blood samples from HIV-infected men with lipodystrophy syndrome (HIV+LIPO+ = 10), HIV-infected men without lipodystrophy syndrome (HIV+LIPO- = 22), and healthy subjects (control = 12), the ..
  66. ncbi Structural and immunochemical characterization of a Neisseria gonorrhoeae epitope defined by a monoclonal antibody 2C7; the antibody recognizes a conserved epitope on specific lipo-oligosaccharides in spite of the presence of human carbohydrate epitopes
    R Yamasaki
    Department of Biochemistry and Biotechnology, Tottori University, Tottori 680 8553, Japan
    J Biol Chem 274:36550-8. 1999
    b>Lipo-oligosaccharides (LOS) produced by Neisseria gonorrhoeae are important antigenic and immunogenic components of the outer membrane complex...
  67. ncbi Human factor H interacts selectively with Neisseria gonorrhoeae and results in species-specific complement evasion
    Jutamas Ngampasutadol
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 180:3426-35. 2008
    Complement forms a key arm of innate immune defenses against gonococcal infection. Sialylation of gonococcal lipo-oligosaccharide, or expression of porin 1A (Por1A) protein, enables Neisseria gonorrhoeae to bind the alternative pathway ..
  68. ncbi Genetic basis of uterine leiomyoma: involvement of high mobility group protein genes
    W J Van de Ven
    Laboratory for Molecular Oncology, Center for Human Genetics, University of Leuven, and Flanders Interuniversity Institute for Biotechnology, Belgium
    Eur J Obstet Gynecol Reprod Biol 81:289-93. 1998
    ..12q13-15 or 6p21 has led to the discovery that two members of the high-mobility group (HMG) protein gene family, HMGIC and HMGIY, are frequently rearranged in such tumors...
  69. ncbi Construction and analysis of cells lacking the HMGA gene family
    Brett Beitzel
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, 10010 N Torrey Pines Road, La Jolla, CA 92037, USA
    Nucleic Acids Res 31:5025-32. 2003
    ..high mobility group A (HMGA) family of non-histone chromosomal proteins is encoded by two related genes, HMGA1 and HMGA2. HMGA proteins are architectural transcription factors that have been found to regulate the transcription of a ..
  70. ncbi A crucial role of a high mobility group protein HMGA2 in cardiogenesis
    Koshiro Monzen
    Department of Cardiovascular Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nat Cell Biol 10:567-74. 2008
    ..This leads to the active transcription of their target genes. Here we show that HMGA2, a member of the HMGA sub-family of HMG proteins, has a critical function in cardiogenesis...
  71. ncbi In nondiabetic, human immunodeficiency virus-infected patients with lipodystrophy, hepatic insulin extraction and posthepatic insulin clearance rate are decreased in proportion to insulin resistance
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Metabolism 54:171-9. 2005
    ..We studied 18 HIV-infected patients with lipodystrophy (LIPO) on antiretroviral therapy and 25 HIV-infected patients without lipodystrophy (controls) of whom 18 were on ..
  72. ncbi HMGA1 and HMGA2 rearrangements in mass-forming endometriosis
    Fabiola Medeiros
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Genes Chromosomes Cancer 49:630-4. 2010
    ..endometriosis, and six endometriomas were investigated by fluorescence in situ hybridization (FISH) for HMGA1 and HMGA2 loci, performed on paraffin-embedded thin tissue sections with custom-designed probes...
  73. ncbi Single-agent liposomal all-trans retinoic acid can cure some patients with untreated acute promyelocytic leukemia: an update of The University of Texas M. D. Anderson Cancer Center Series
    Apostolia Maria Tsimberidou
    Department of Leukemia, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    Leuk Lymphoma 47:1062-8. 2006
    The present study aimed to investigate single-agent liposomal all-trans retinoic acid (Lipo-ATRA) in untreated acute promyelocytic leukemia (APL). Induction therapy consisted of Lipo-ATRA 90 mg/m2 i.v. every other day...
  74. ncbi [Pharmacodynamics, pharmacokinetics and tissue distribution of liposomal mitoxantrone hydrochloride]
    Cai Xia Wang
    Hebei Pharmaceutical Technology and Engineering Research Center, Shijiazhuang 050051, China
    Yao Xue Xue Bao 45:1565-9. 2010
    ..study is to compare the pharmacodynamics, pharmacokinetics and tissue distribution of liposomal mitoxantrone (Mit-lipo) and free mitoxantrone (Mit-free)...
  75. ncbi A dose-response study of epidural liposomal bupivacaine in rabbits
    J M Malinovsky
    Laboratoire d Anesthésie et Chirurgie Expérimentale, Universite de Nantes, Nantes, France
    J Control Release 60:111-9. 1999
    ..phosphatidylcholine-cholesterol) suspensions contained 20 mg ml-1 of lipid, and different doses of bupivacaine (Lipo 7.5=7.5-; Lipo 3.7=3. 75-; Lipo 2.5=2.5-; Lipo 1.2=1.25-; and Lipo 0.7=0.65-mg of bupivacaine per ml)...
  76. ncbi Mutation of the htrB locus of Haemophilus influenzae nontypable strain 2019 is associated with modifications of lipid A and phosphorylation of the lipo-oligosaccharide
    N G Lee
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    J Biol Chem 270:27151-9. 1995
    ..SDS-polyacrylamide gel electrophoresis analysis revealed that the lipo-oligosaccharide (LOS) isolated from these mutants migrated faster than the wild type LOS and its color changed from ..
  77. ncbi Energetics of binding the mammalian high mobility group protein HMGA2 to poly(dA-dT)2 and poly(dA)-poly(dT)
    Tengjiao Cui
    Department of Chemistry and Biochemistry, Florida International University, Miami, FL 33199, USA
    J Mol Biol 352:629-45. 2005
    The mammalian high mobility group protein A2 (HMGA2) is a chromosomal architectural transcription factor involved in oncogenesis and cell transformation...
  78. ncbi Co-encapsulation of gallium with gentamicin in liposomes enhances antimicrobial activity of gentamicin against Pseudomonas aeruginosa
    M Halwani
    The Novel Drug and Vaccine Delivery Systems Facility, Department of Chemistry and Biochemistry, Laurentian University, Sudbury, Ontario, Canada P3E 2C6
    J Antimicrob Chemother 62:1291-7. 2008
    The aim of this study was to enhance the antimicrobial efficacy of a liposomal gentamicin formulation with gallium metal (Lipo-Ga-GEN) against clinical isolates of Pseudomonas aeruginosa.
  79. ncbi [Contributions and results of lipo-structure in repair and rejuvenation of frontal anatomical unit]
    A Chichery
    Service de Chirurgie Plastique, centre hospitalier Saint Luc et Saint Joseph, 20, Quai Claude Bernard, 69003 Lyon, France
    Ann Chir Plast Esthet 54:93-102. 2009
    ..In this work, we want to estimate contribution of lipo-structure in repair and rejuvenation of frontal anatomical unit (FAU)...
  80. ncbi Skeletal muscle insulin signaling defects downstream of phosphatidylinositol 3-kinase at the level of Akt are associated with impaired nonoxidative glucose disposal in HIV lipodystrophy
    Steen B Haugaard
    Department of Infectious Diseases, Clinical Research Unit 136, Hvidovre University Hospital, DK 2650 Hvidovre, Copenhagen, Denmark
    Diabetes 54:3474-83. 2005
    ..Skeletal muscle biopsies, obtained from 18 lipodystrophic nondiabetic patients (LIPO) and 18 nondiabetic patients without lipodystrophy (NONLIPO) before and during hyperinsulinemic (40 mU.m(-2)...
  81. ncbi Binding the mammalian high mobility group protein AT-hook 2 to AT-rich deoxyoligonucleotides: enthalpy-entropy compensation
    Suzanne Joynt
    Department of Chemistry and Biochemistry, Florida International University, Miami, Florida 33199, USA
    Biophys J 96:4144-52. 2009
    b>HMGA2 is a DNA minor-groove binding protein...
  82. ncbi [Intravenous delivery of cationic liposomes conjugation to recombinant adenoviral vectors containing human endostatin gene inhibits ovarian cancer growth in nude mice]
    Li Wang
    Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 40:190-4. 2009
    ..To evaluate the anticancer effect of liposome plus Ad-Endostatin complex on human ovarian serous cystocarcinoma...
  83. ncbi Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients who display fat redistribution
    Steen B Haugaard
    Clinical Research Unit, Hvidovre University Hospital, DK 2650 Hvidore, Copenhagen, Denmark
    Metabolism 56:939-46. 2007
    ..To address this issue, the secretion patterns of SP and IP of 16 HIV-infected men with lipodystrophy (LIPO) and 15 HIV-infected men without lipodystrophy (NONLIPO) were studied during an oral glucose tolerance test (OGTT)...
  84. ncbi Expression of the early nodulin, ENOD40, in soybean roots in response to various lipo-chitin signal molecules
    E Minami
    Department of Microbiology, University of Tennessee, Knoxville 37996 0845, USA
    Plant J 10:23-32. 1996
    The lipo-chitin (LCO) nodulation signal (nod signal) purified from Bradyrhizobium japonicum induced nodule primordia on soybean (i.e. Glycine soja) roots...
  85. ncbi NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Genes Chromosomes Cancer 47:971-7. 2008
    Lipomas are frequently characterized by rearrangements resulting in the fusion of the HMGA2 gene (12q14.3) with a variety of partners. Chromosome band 9p22 rearrangements occur in about 1% of lipomas...
  86. ncbi Defective glucose and lipid metabolism in human immunodeficiency virus-infected patients with lipodystrophy involve liver, muscle tissue and pancreatic beta-cells
    Steen B Haugaard
    Department of Infectious Diseases, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Endocrinol 152:103-12. 2005
    ..Aiming to provide a detailed description of the metabolic adverse effects of HIV-lipodystrophy, we investigated several aspects of glucose metabolism, lipid metabolism and beta-cell function in lipodystrophic HIV-infected patients...
  87. ncbi Hyperproinsulinaemia in normoglycaemic lipodystrophic HIV-infected patients
    S B Haugaard
    Department of Endocrinology and Internal Medicine, Hvidovre University Hospital, Copenhagen, Denmark
    Eur J Clin Invest 36:436-45. 2006
    ..precursors, intact (IP) and 32-33 split proinsulin (SP), which are elevated in states of insulin resistance and predict type 2 diabetes, would be elevated in human immunodeficiency virus (HIV)-infected patients with lipodystrophy (LIPO).
  88. ncbi Polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein are associated with chronic spontaneous urticaria and urinary leukotriene E4
    Gabriele Di Lorenzo
    Dipartimento di Medicina Clinica e delle Patologie Emergenti, Universita di Palermo, Palermo, Italy
    Eur J Dermatol 21:47-52. 2011
    ..Our working hypothesis is that polymorphisms of cyclo-oxygenases and 5-lipo-oxygenase-activating protein may be involved in the pathways leading to CSU...
  89. ncbi Nodulation protein NodL of Rhizobium leguminosarum O-acetylates lipo-oligosaccharides, chitin fragments and N-acetylglucosamine in vitro
    G V Bloemberg
    Institute of Molecular Plant Sciences, Leiden University, The Netherlands
    Mol Microbiol 11:793-804. 1994
    Upon induction of their nodulation genes, the root nodule-inducing Rhizobium bacteria produce lipo-oligosaccharide signal molecules. All lipo-oligosaccharides identified from Rhizobium leguminosarum bv...
  90. ncbi Structural identification of the lipo-chitin oligosaccharide nodulation signals of Rhizobium loti
    I M Lopez-Lara
    Institute of Molecular Plant Sciences, Leiden University, The Netherlands
    Mol Microbiol 15:627-38. 1995
    ..loti, but not by most other Rhizobium strains, indicating that R. loti produces specific lipo-chitin oligosaccharides (LCOs) which are necessary for the nodulation of Lotus plants...
  91. ncbi Structural identification of metabolites produced by the NodB and NodC proteins of Rhizobium leguminosarum
    H P Spaink
    Institute of Molecular Plant Sciences, Leiden University, The Netherlands
    Mol Microbiol 13:821-31. 1994
    The Rhizobium nodulation genes nodABC are involved in the synthesis of lipo-chitin oligosaccharides...
  92. ncbi Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
    PLoS ONE 7:e45468. 2012
    ..111)In-labeled human atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes containing doxorubicin (Lipo-Dox; AP-1 Lipo-Dox) were used as a microSPECT probe for radioactivity measurements in the GBM-bearing mice...
  93. ncbi Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours
    A P Dei Tos
    Department of Pathology, Regional Hospitals, Treviso, Italy
    J Pathol 190:531-6. 2000
    ..These findings not only provide insights into the molecular pathogenesis of lipomatous tumours, but also indicate that the immunohistochemical analysis of mdm2 and cdk4 may help to increase diagnostic accuracy...
  94. ncbi Therapeutic effects of carbogen inhalation and lipo-prostaglandin E1 in sudden hearing loss
    Hyun Jin Lee
    Department of Otorhinolaryngology Head and Neck Surgery, Chung Ang University College of Medicine, Seoul, Korea
    Yonsei Med J 53:999-1004. 2012
    ..Treatments include carbogen inhalation and lipo-prostaglandin E1 (lipo-PGE1), both of which have circulation-enhancing effects...
  95. ncbi Identification of a HMGA2-EFCAB6 gene rearrangement following next-generation sequencing in a patient with a t(12;22)(q14.3;q13.2) and JAK2V617F-positive myeloproliferative neoplasm
    S Eric Martin
    Helen F Graham Cancer Center, Newark, DE, USA
    Cancer Genet 205:295-303. 2012
    ..Next-generation sequencing revealed a balanced HMGA2-EFCAB6 genomic rearrangement...
  96. ncbi Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme
    Feng Yi Yang
    Department of Biomedical Imaging and Radiological Sciences, National Yang Ming University, Taipei, Taiwan
    J Control Release 160:652-8. 2012
    ..HIFU and human atherosclerotic plaque-specific peptide-1 (AP-1)-conjugated liposomes containing doxorubicin (AP-1 Lipo-Dox) act synergistically in an experimental brain tumor model...
  97. ncbi HPLC analysis of lipoproteins in culture medium of hepatoma cells: an in vitro system for screening antihyperlipidemic drugs
    Mizuho Itoh
    Skylight Biotech Inc, 100 4 Sunada, Iijima, Akita, 010 0911, Japan
    Biotechnol Lett 31:953-7. 2009
    We isolated a HepG2-derived sub-clone (HepG2-Lipo), which possessed an increased lipoprotein synthesizing ability. HepG2-Lipo cells could secrete triglycerides (TG) and cholesterol at rates 9...
  98. ncbi Hmga2 promotes neural stem cell self-renewal in young but not old mice by reducing p16Ink4a and p19Arf Expression
    Jinsuke Nishino
    Howard Hughes Medical Institute, Life Sciences Institute, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109 2216, USA
    Cell 135:227-39. 2008
    ..We discovered that the Hmga2 transcriptional regulator is highly expressed in fetal neural stem cells but that expression declines with age...
  99. ncbi The second AT-hook of the architectural transcription factor HMGA2 is determinant for nuclear localization and function
    Giacomo Cattaruzzi
    Dipartimento di Scienze e Tecnologie Biomediche, University of Udine, Udine, Italy
    Nucleic Acids Res 35:1751-60. 2007
    ..Here, we report the identification and characterization of a nuclear localization signal (NLS) for HMGA2, a member of the HMGA family...
  100. ncbi Nano PGE1 promoted the recovery from spinal cord injury-induced motor dysfunction through its accumulation and sustained release
    Mitsuko Takenaga
    Institute of Medical Science, St Marianna University School of Medicine, Kawasaki, Japan
    J Control Release 148:249-54. 2010
    ..from SCI-induced motor dysfunction, and the potency of Nano PGE(1) was comparable with successive treatment of Lipo PGE(1), and was superior to single treatment of Lipo PGE(1)...

Research Grants63

  1. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    NILS WALTER; Fiscal Year: 2007
    ..to regulate expression of disease-related transcriptional effectors, among them the High Mobility Group AT-hook 2 (HMGA2) protein involved in transcriptional regulation and associated with various cancers as well as diet-induced ..
  2. Trekking with the Ribognome: Single Molecule Microscopy of Intracellular miRNPs
    Nils G Walter; Fiscal Year: 2010
    ..to regulate expression of disease-related transcriptional effectors, among them the High Mobility Group AT-hook 2 (HMGA2) protein involved in transcriptional regulation and associated with various cancers as well as diet-induced ..
  3. MOLECULAR PROGRAMMING OF SALIVARY GLAND GENE EXPRESSION
    David Ann; Fiscal Year: 2002
    ..Moreover, the proposed study is of great significance as the dysregulation of this Raf-1 mediated process could lead to cell transformation. ..
  4. RpoS-mediated virulence regulation in Borrelia burgdorferi
    JON SCOTT BLEVINS; Fiscal Year: 2010
    ..undergoes significant adaptive changes, which includes altering the expression of several major outer surface (lipo)proteins...
  5. Glycopeptide Complexes with Bacterial Cell Walls by REDOR NMR
    Jacob Schaefer; Fiscal Year: 2010
    ..to the biomedically relevant characterization of new types of cyclic antimicrobial peptides, lipodecapeptides and lipo-octapeptides...
  6. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions through sterol-response element binding protein-1c (SREBP-1c) is limited, as is the role of ..
  7. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    KAMAL MEHTA; Fiscal Year: 2009
    ..Also, our knowledge of the signaling pathway controlling adipose endocrine and lipo-metabolic functions through sterol-response element binding protein-1c (SREBP-1c) is limited, as is the role of ..
  8. Genetic Studies of Uterine Leiomyomata
    CYNTHIA CASSON MORTON; Fiscal Year: 2010
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGA2 and HMGA1, located on chromosomes 12 and 6, respectively, participate in the pathobiology of uterine leiomyomata, ..
  9. Structure and Function of Treponema pallidum Lipoproteins
    MICHAEL NORGARD; Fiscal Year: 2009
    ..seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo) proteins of the organism. These membrane proteins likely play strategic roles in sustaining T...
  10. Structure and Function of Treponema pallidum Lipoproteins
    Michael V Norgard; Fiscal Year: 2010
    ..seeks to use molecular biology and structural biology to determine the structures and functions of key membrane (lipo) proteins of the organism. These membrane proteins likely play strategic roles in sustaining T...
  11. Regulation of Signaling Receptor Activity by LRP-1
    Steven L Gonias; Fiscal Year: 2010
    ..b>Lipo- polysaccharide challenge experiments will be conducted in mice in which LRP-1 is conditionally deleted in ..
  12. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2007
    ..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
  13. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2009
    ..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
  14. Polymer-Based Yersinia Pestis Point-of-Case Diagnostics
    Jean Clarke; Fiscal Year: 2004
    ..amplification of fluorescence transduction events to rapidly identify species-specific genomic, proteomic, and lipo-oligosaccharide (LOS) markers of Y. pestis...
  15. The role of PON-2 and PON3 proteins in atherosclerosis
    Srinivasa Reddy; Fiscal Year: 2010
    ..activities of PON proteins are a result of their activity towards a class of unidentified pro-inflammatory lipo-lactones that participate in LDL oxidation...
  16. MOLECULAR AND CYTOGENETIC STUDIES OF UTERINE LEIOMYOMATA
    Cynthia Morton; Fiscal Year: 2002
    ..been successful in using positional candidate gene approaches in determining that two high mobility protein genes, HMGIC and HMGlY, located on chromosomes 12 and 6, respectively participate in the pathobiology of uterine leiomyomata...
  17. Saw Palmetto, Cyclooxygenase, and Prostate Cancer
    CHARLES ROSELLI; Fiscal Year: 2006
    ..The lipo-sterolic extract of saw palmetto (SPE) has been shown to be as effective as finasteride in the treatment of urinary ..
  18. Metabotropic glutamate receptors in the vagal processing of taste information
    ROBERT HALLOCK; Fiscal Year: 2007
    ..Second, mGluR agonists have recently been shown to decrease lipo-polysaccharide induced anorexia...
  19. ENVIRONMENTAL ESTROGENS AND UTERINE LEIOMYOMA
    Cheryl Walker; Fiscal Year: 2006
    ..abstract_text> ..
  20. LIPID GROWTH FACTOR FOR NORMAL AND MALIGNANT B CELLS
    Ulrich Hammerling; Fiscal Year: 1993
    We have identified a lipo-protein complex with growth-promoting properties in supernates of human lymphoblastoid cell lines and activated normal B cells. The protein moiety is prealbumin which originates from the culture medium...
  21. The Role of MicroRNAs in Tumor Progression
    Marcus E Peter; Fiscal Year: 2010
    ..The early embryonic gene HMGA2 was found to be a prime target of let-7 and was found to be upregulated in tumor cells from advanced ovarian ..
  22. Novel Fas/CD95 Signaling Mechanisms
    Marcus E Peter; Fiscal Year: 2010
    ..expression of the microRNA let-7 and we obtained evidence that let-7 drives tumor progression through targeting HMGA2 and IMP-1...
  23. Validation of HMGI-C as a Drug Target in Colon Cancer
    ROLAND CHOUINARD; Fiscal Year: 2002
    ..It is now estimated that in the United States alone, 129,400 new cases of colon cancer were reported, indicating the demand for safe, reliable pharmaceuticals. ..