HMGA1

Summary

Gene Symbol: HMGA1
Description: high mobility group AT-hook 1
Alias: HMG-R, HMGA1A, HMGIY, high mobility group protein HMG-I/HMG-Y, high mobility group protein A1, high mobility group protein R, high-mobility group (nonhistone chromosomal) protein isoforms I and Y, nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y
Species: human
Products:     HMGA1

Top Publications

  1. Hillion J, Dhara S, Sumter T, Mukherjee M, Di Cello F, Belton A, et al. The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?. Cancer Res. 2008;68:10121-7 pubmed publisher
    ..HMGA1 encodes the HMGA1a and HMGA1b protein isoforms, which function in regulating gene expression...
  2. Reeves R, Beckerbauer L. HMGI/Y proteins: flexible regulators of transcription and chromatin structure. Biochim Biophys Acta. 2001;1519:13-29 pubmed
  3. Treff N, Dement G, Adair J, Britt R, Nie R, Shima J, et al. Human KIT ligand promoter is positively regulated by HMGA1 in breast and ovarian cancer cells. Oncogene. 2004;23:8557-62 pubmed
    ..to facilitate malignant transformation of cancer cells, we have used a variety of methods to determine whether HMGA1a directly regulates the human KL promoter in breast and ovarian cancer cells...
  4. Adair J, Maloney S, Dement G, Wertzler K, Smerdon M, Reeves R. High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A. Cancer Res. 2007;67:6044-52 pubmed
    Cells that overexpress high-mobility group A1 (HMGA1) proteins exhibit deficient nucleotide excision repair (NER) after exposure to DNA-damaging agents, a condition ameliorated by artificially lowering intracellular levels of these ..
  5. Marquez M, Huyvaert M, Perry J, Pearson R, Falchi M, Morris A, et al. Low-frequency variants in HMGA1 are not associated with type 2 diabetes risk. Diabetes. 2012;61:524-30 pubmed publisher
    It has recently been suggested that the low-frequency c.136-14_136-13insC variant in high-mobility group A1 (HMGA1) may strongly contribute to insulin resistance and type 2 diabetes risk...
  6. Chin M, Pellacani A, Wang H, Lin S, Jain M, Perrella M, et al. Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). J Biol Chem. 1998;273:9755-60 pubmed
    ..Our observations suggest that members of the HMG-I family play an important role in SRF-dependent transcription and that their effect is mediated primarily by a protein-protein interaction. ..
  7. Harrer M, Lührs H, Bustin M, Scheer U, Hock R. Dynamic interaction of HMGA1a proteins with chromatin. J Cell Sci. 2004;117:3459-71 pubmed
    ..protein (GFP) and fluorescence recovery after photobleaching (FRAP) to analyze the distribution and dynamics of HMGA1a in vivo...
  8. Wei J, Wu X, Peng Y, Shi G, Basturk O, Olca B, et al. Regulation of HMGA1 expression by microRNA-296 affects prostate cancer growth and invasion. Clin Cancer Res. 2011;17:1297-305 pubmed publisher
    High-motility group AT-hook gene 1 (HMGA1) is a non-histone nuclear binding protein that is developmentally regulated. HMGA1 is significantly overexpressed in and associated with high grade and advance stage of prostate cancer (PC)...
  9. Aiello A, Pandini G, Sarfstein R, Werner H, Manfioletti G, Vigneri R, et al. HMGA1 protein is a positive regulator of the insulin-like growth factor-I receptor gene. Eur J Cancer. 2010;46:1919-26 pubmed publisher
    ..High Mobility Group A1 (HMGA1) is a non-histone chromatin protein that has the ability to regulate gene expression through DNA binding and ..

More Information

Publications75

  1. Foti D, Iuliano R, Chiefari E, Brunetti A. A nucleoprotein complex containing Sp1, C/EBP beta, and HMGI-Y controls human insulin receptor gene transcription. Mol Cell Biol. 2003;23:2720-32 pubmed
  2. Manabe T, Ohe K, Katayama T, Matsuzaki S, Yanagita T, Okuda H, et al. HMGA1a: sequence-specific RNA-binding factor causing sporadic Alzheimer's disease-linked exon skipping of presenilin-2 pre-mRNA. Genes Cells. 2007;12:1179-91 pubmed
    ..We previously purified and identified high mobility group A protein 1a (HMGA1a) as a trans-acting factor responsible for aberrant exon 5 skipping...
  3. Wood L, Mukherjee M, Dolde C, Xu Y, Maher J, Bunton T, et al. HMG-I/Y, a new c-Myc target gene and potential oncogene. Mol Cell Biol. 2000;20:5490-502 pubmed
    ..These findings indicate that HMG-I/Y is a c-Myc target gene involved in neoplastic transformation and a member of a new class of potential oncogenes. ..
  4. Hristov A, Cope L, Di Cello F, Reyes M, Singh M, Hillion J, et al. HMGA1 correlates with advanced tumor grade and decreased survival in pancreatic ductal adenocarcinoma. Mod Pathol. 2010;23:98-104 pubmed publisher
    ..By real-time quantitative RT-PCR, we measured HMGA1a mRNA in cultured pancreatic ductal adenocarcinoma cell lines and found increased levels in all cancer cells ..
  5. Manabe T, Katayama T, Tohyama M. HMGA1a recognition candidate DNA sequences in humans. PLoS ONE. 2009;4:e8004 pubmed publisher
    High mobility group protein A1a (HMGA1a) acts as an architectural transcription factor and influences a diverse array of normal biological processes...
  6. Schlueter C, Hauke S, Loeschke S, Wenk H, Bullerdiek J. HMGA1 proteins in human atherosclerotic plaques. Pathol Res Pract. 2005;201:101-7 pubmed
    ..A group of molecules that may act as a main regulator of SMC phenotype switching is formed by the so-called HMGA1 high-mobility group proteins...
  7. Takaha N, Sowa Y, Takeuchi I, Hongo F, Kawauchi A, Miki T. Expression and role of HMGA1 in renal cell carcinoma. J Urol. 2012;187:2215-22 pubmed publisher
    ..b>HMGA1 is over expressed in many types of cancer and it is associated with metastatic potential...
  8. Lin S. Identification of an NF-Y/HMG-I(Y)-binding site in the human IL-10 promoter. Mol Immunol. 2006;43:1325-31 pubmed
    ..These findings suggest that NF-Y and HMG-I(Y) may play an important role in regulating the IL-10 promoter activity in B cells. ..
  9. Pierantoni G, Fedele M, Pentimalli F, Benvenuto G, Pero R, Viglietto G, et al. High mobility group I (Y) proteins bind HIPK2, a serine-threonine kinase protein which inhibits cell growth. Oncogene. 2001;20:6132-41 pubmed
    ..Since normal thyroid cells do not express detectable HMGI(Y) protein levels, we assume that the HIPK2 inhibitory effect is independent from the interaction with the HMGI(Y) protein. ..
  10. Duncan B, Zhao K. HMGA1 mediates the activation of the CRYAB promoter by BRG1. DNA Cell Biol. 2007;26:745-52 pubmed
    ..An AT-rich sequence within this region is bound by the high-mobility group AT-hook 1 (HMGA1) proteins in vitro and in vivo...
  11. Costa V, Foti D, Paonessa F, Chiefari E, Palaia L, Brunetti G, et al. The insulin receptor: a new anticancer target for peroxisome proliferator-activated receptor-gamma (PPARgamma) and thiazolidinedione-PPARgamma agonists. Endocr Relat Cancer. 2008;15:325-35 pubmed publisher
    ..Our results demonstrate that IR is a new target gene of PPARgamma, and support a potential use of TZDs as anti-proliferative agents in selected neoplastic tissues overexpressing IRs. ..
  12. Akaboshi S, Watanabe S, Hino Y, Sekita Y, Xi Y, Araki K, et al. HMGA1 is induced by Wnt/beta-catenin pathway and maintains cell proliferation in gastric cancer. Am J Pathol. 2009;175:1675-85 pubmed publisher
    ..Here we report that HMGA1 is induced by the Wnt/beta-catenin pathway and maintains proliferation of gastric cancer cells...
  13. Mu G, Liu H, Zhou F, Xu X, Jiang H, Wang Y, et al. Correlation of overexpression of HMGA1 and HMGA2 with poor tumor differentiation, invasion, and proliferation associated with let-7 down-regulation in retinoblastomas. Hum Pathol. 2010;41:493-502 pubmed publisher
    ..04; r = -0.392, P = .007, respectively). Our findings imply that the overexpressions of high-mobility group A1, high-mobility group A2, and down-regulation of let-7 may be associated with tumorigenesis and progression of retinoblastomas. ..
  14. Palmieri D, D Angelo D, Valentino T, De Martino I, Ferraro A, Wierinckx A, et al. Downregulation of HMGA-targeting microRNAs has a critical role in human pituitary tumorigenesis. Oncogene. 2012;31:3857-65 pubmed publisher
    ..A (HMGA) genes are overexpressed in pituitary adenomas, and consistently transgenic mice overexpressing either the Hmga1 or the Hmga2 gene develop mixed growth hormone/prolactin (GH-PRL)-secreting pituitary adenomas...
  15. Friedmann M, Holth L, Zoghbi H, Reeves R. Organization, inducible-expression and chromosome localization of the human HMG-I(Y) nonhistone protein gene. Nucleic Acids Res. 1993;21:4259-67 pubmed
    ..And, finally, we localized the gene to the short arm of chromosome 6 (6p) in a region that is known to be involved in rearrangements, translocations and other abnormalities correlated with a number of human cancers. ..
  16. Johnson K, Lehn D, Reeves R. Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y. Mol Cell Biol. 1989;9:2114-23 pubmed
    ..Several additional but probably nonfunctional HMG-I or HMG-Y gene copies exist in the human genome; we isolated and partially sequenced one of these pseudogenes and found that it is a processed HMG-Y retropseudogene. ..
  17. Liau S, Jazag A, Whang E. HMGA1 is a determinant of cellular invasiveness and in vivo metastatic potential in pancreatic adenocarcinoma. Cancer Res. 2006;66:11613-22 pubmed
    b>HMGA1 proteins are architectural transcription factors that are overexpressed in a range of human malignancies, including pancreatic adenocarcinoma...
  18. Shah S, Cope L, Poh W, Belton A, Roy S, Talbot C, et al. HMGA1: a master regulator of tumor progression in triple-negative breast cancer cells. PLoS ONE. 2013;8:e63419 pubmed publisher
    ..Here, we show for the first time that the high mobility group A1 (HMGA1) gene drives metastatic progression in triple negative breast cancer cells (MDA-MB-231, Hs578T) by reprogramming ..
  19. Foti D, Chiefari E, Fedele M, Iuliano R, Brunetti L, Paonessa F, et al. Lack of the architectural factor HMGA1 causes insulin resistance and diabetes in humans and mice. Nat Med. 2005;11:765-73 pubmed
    ..Here we report a genetic flaw that markedly reduced the intracellular expression of the high mobility group A1 (HMGA1) protein, and adversely affected insulin receptor expression in cells and tissues from four subjects with insulin ..
  20. Chuma M, Saeki N, Yamamoto Y, Ohta T, Asaka M, Hirohashi S, et al. Expression profiling in hepatocellular carcinoma with intrahepatic metastasis: identification of high-mobility group I(Y) protein as a molecular marker of hepatocellular carcinoma metastasis. Keio J Med. 2004;53:90-7 pubmed
    ..HMG-I(Y) expression was associated with intrahepatic metastasis and may be a predictive marker of HCC intrahepatic metastasis. ..
  21. Cleynen I, Van de Ven W. The HMGA proteins: a myriad of functions (Review). Int J Oncol. 2008;32:289-305 pubmed
    The 'high mobility group' HMGA protein family consists of four members: HMGA1a, HMGA1b and HMGA1c, which result from translation of alternative spliced forms of one gene and HMGA2, which is encoded for by another gene...
  22. Nagpal S, Ghosn C, DiSepio D, Molina Y, Sutter M, Klein E, et al. Retinoid-dependent recruitment of a histone H1 displacement activity by retinoic acid receptor. J Biol Chem. 1999;274:22563-8 pubmed
  23. Chiappetta G, Botti G, Monaco M, Pasquinelli R, Pentimalli F, Di Bonito M, et al. HMGA1 protein overexpression in human breast carcinomas: correlation with ErbB2 expression. Clin Cancer Res. 2004;10:7637-44 pubmed
    We measured, by immunohistochemistry, HMGA1 protein expression in 212 breast tissue specimens: 6 normal samples, 28 hyperplastic lesions (13 with cellular atypia), 11 fibroadenomas, 10 in situ ductal carcinomas, 144 ductal carcinomas, ..
  24. Huth J, Bewley C, Nissen M, Evans J, Reeves R, Gronenborn A, et al. The solution structure of an HMG-I(Y)-DNA complex defines a new architectural minor groove binding motif. Nat Struct Biol. 1997;4:657-65 pubmed
    ..The absence of one of these modules in the third DNA binding domain accounts for its-100 fold reduced affinity relative to the second one. ..
  25. Manabe T, Katayama T, Sato N, Gomi F, Hitomi J, Yanagita T, et al. Induced HMGA1a expression causes aberrant splicing of Presenilin-2 pre-mRNA in sporadic Alzheimer's disease. Cell Death Differ. 2003;10:698-708 pubmed
    ..The factor was identified as the high mobility group A1a protein (HMGA1a; formerly HMG-I). HMGA1a bound to a specific sequence on exon 5, located upstream of the 5' splice site...
  26. Hillion J, Wood L, Mukherjee M, Bhattacharya R, Di Cello F, Kowalski J, et al. Upregulation of MMP-2 by HMGA1 promotes transformation in undifferentiated, large-cell lung cancer. Mol Cancer Res. 2009;7:1803-12 pubmed publisher
    ..Here, we show that HMGA1 is an important oncogene that drives transformation in undifferentiated, large-cell carcinoma...
  27. Dolde C, Mukherjee M, Cho C, Resar L. HMG-I/Y in human breast cancer cell lines. Breast Cancer Res Treat. 2002;71:181-91 pubmed
  28. Reeves R, Nissen M. The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure. J Biol Chem. 1990;265:8573-82 pubmed
    ..The predicted BD peptide structure, which we refer to as the "A.T-hook," represents a previously undescribed DNA-binding motif capable of binding to the minor groove of stretches of A.T base pairs. ..
  29. Chiappetta G, Tallini G, De Biasio M, Manfioletti G, Martinez Tello F, Pentimalli F, et al. Detection of high mobility group I HMGI(Y) protein in the diagnosis of thyroid tumors: HMGI(Y) expression represents a potential diagnostic indicator of carcinoma. Cancer Res. 1998;58:4193-8 pubmed
    ..The findings of this study confirm the differential expression of HMGI(Y) in thyroid neoplasia and indicate the HMGI(Y) protein as a potential marker for thyroid carcinoma. ..
  30. Abdulkadir S, Casolaro V, Tai A, Thanos D, Ono S. High mobility group I/Y protein functions as a specific cofactor for Oct-2A: mapping of interaction domains. J Leukoc Biol. 1998;64:681-91 pubmed
    ..These studies support the view that HMG I(Y) is an important cofactor for HLA-DRA gene activation by Oct-2A and provide insights into its mechanism of action. ..
  31. Chiefari E, Iiritano S, Paonessa F, Le Pera I, Arcidiacono B, Filocamo M, et al. Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Nat Commun. 2010;1:40 pubmed publisher
    ..Previously, we demonstrated that high mobility group A1 (HMGA1) protein regulates the insulin receptor (INSR) gene and that two diabetic patients demonstrated a marked ..
  32. Liu L, Ding H, Wang H, Xu Y, Cui G, Wang P, et al. Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals. Diabetologia. 2012;55:1685-8 pubmed publisher
    Variants of the high-mobility group A1 (HMGA1) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin...
  33. Liau S, Rocha F, Matros E, Redston M, Whang E. High mobility group AT-hook 1 (HMGA1) is an independent prognostic factor and novel therapeutic target in pancreatic adenocarcinoma. Cancer. 2008;113:302-14 pubmed publisher
    High mobility group AT-hook 1 (HMGA1) proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas...
  34. Liau S, Whang E. HMGA1 is a molecular determinant of chemoresistance to gemcitabine in pancreatic adenocarcinoma. Clin Cancer Res. 2008;14:1470-7 pubmed publisher
    b>HMGA1 proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas...
  35. Shah S, Kerr C, Cope L, Zambidis E, Liu C, Hillion J, et al. HMGA1 reprograms somatic cells into pluripotent stem cells by inducing stem cell transcriptional networks. PLoS ONE. 2012;7:e48533 pubmed publisher
    ..The high mobility group A1 (HMGA1) gene is highly expressed in hESCs and poorly differentiated, stem-like cancers; however, its role in these ..
  36. Yanagita T, Manabe T, Okuda H, Matsuzaki S, Bando Y, Katayama T, et al. Possible involvement of the expression and phosphorylation of N-Myc in the induction of HMGA1a by hypoxia in the human neuroblastoma cell line. Neurosci Lett. 2005;374:47-52 pubmed
    Increased expression of N-Myc and expression of the high mobility group protein A1a (HMGA1a) were observed in the nuclei of SK-N-SH cells following exposure to hypoxia...
  37. Chiefari E, Tanyolac S, Paonessa F, Pullinger C, Capula C, Iiritano S, et al. Functional variants of the HMGA1 gene and type 2 diabetes mellitus. JAMA. 2011;305:903-12 pubmed publisher
    High-mobility group A1 (HMGA1) protein is a key regulator of insulin receptor (INSR) gene expression...
  38. Iiritano S, Chiefari E, Ventura V, Arcidiacono B, Possidente K, Nocera A, et al. The HMGA1-IGF-I/IGFBP system: a novel pathway for modulating glucose uptake. Mol Endocrinol. 2012;26:1578-89 pubmed publisher
    We previously showed that loss of the high mobility group A1 (HMGA1) protein expression, induced in mice by disrupting the Hmga1 gene, considerably decreased insulin receptor expression in the major target tissues of insulin action, ..
  39. Takamiya R, Baron R, Yet S, Layne M, Perrella M. High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression. FEBS Lett. 2008;582:810-4 pubmed publisher
    ..Using a small molecule inhibitor of HMGA1 binding to DNA, or a dominant-negative form of HMGA1, we blunted the induction of hNOS2 by pro-inflammatory ..
  40. Hillion J, Roy S, Heydarian M, Cope L, Xian L, Koo M, et al. The High Mobility Group A1 (HMGA1) gene is highly overexpressed in human uterine serous carcinomas and carcinosarcomas and drives Matrix Metalloproteinase-2 (MMP-2) in a subset of tumors. Gynecol Oncol. 2016;141:580-587 pubmed publisher
    ..We previously reported that Hmga1a transgenic mice develop uterine tumors with complete penetrance...
  41. Maillet I, Buhler J, Sentenac A, Labarre J. Rpb4p is necessary for RNA polymerase II activity at high temperature. J Biol Chem. 1999;274:22586-90 pubmed
    ..We also demonstrate that rpb4 null mutant is an appropriate tool to analyze the involvement of transcriptional events in the survival and adaptation to heat shock or other stresses. ..
  42. Jiang Y, Zhao Y, Chen S, Chen L, Li C, Zhou X. Regulation by FSH of the dynamic expression of retinol-binding protein 4 in the mouse ovary. Reprod Biol Endocrinol. 2018;16:25 pubmed publisher
    ..Transcription factors high-mobility group AT-hook 1 (HMGA1), steroidogenic factor 1 (SF-1), and liver receptor homolog 1 (LRH-1) (which have been previously shown to be ..
  43. Wu W, Wan W, Li A. The nuclear architectural protein HMGA1a triggers receptor-mediated endocytosis. J Cell Biochem. 2009;108:791-801 pubmed publisher
    ..However, our results reveal that a HMGA member (HMGA1a) has a unique plasma membrane receptor; this receptor specifically binds to HMGA-decorated species, effectively ..
  44. Beckers J, Herrmann F, Rieger S, Drobyshev A, Horsch M, Hrabe de Angelis M, et al. Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis. Int J Cancer. 2005;114:590-7 pubmed
    ..Supplementary material for this article can be found on the International Journal of Cancer website at http://www.interscience.wiley.com/jpages/0020-7136/suppmat/index.html.) ..
  45. Bianchini L, Birtwisle L, Saada E, Bazin A, Long E, Roussel J, et al. Identification of PPAP2B as a novel recurrent translocation partner gene of HMGA2 in lipomas. Genes Chromosomes Cancer. 2013;52:580-90 pubmed publisher
    ..Moreover, in one case showing a t(1;6)(p32;p21) we observed a rearrangement of PPAP2B and HMGA1, which suggests that HMGA1 might also be a fusion partner for PPAP2B...
  46. Zhu L, Jones C. The high mobility group AT-hook 1 protein stimulates bovine herpesvirus 1 productive infection. Virus Res. 2017;238:236-242 pubmed publisher
    ..subset of latently infected neurons is associated with β-catenin and the high mobility group AT-hook 1 protein (HMGA1), which correlates with increased expression of these proteins in latently infected neurons...
  47. Karlson J, Mørk E, Holtlund J, Laland S, Lund T. The amino acid sequence of the chromosomal protein HMG-Y, its relation to HMG-I and possible domains for the preferential binding of the proteins to stretches of A-T base pairs. Biochem Biophys Res Commun. 1989;158:646-51 pubmed
    ..The binding of peptides derived from HMG-I (after thermolysin cleavage) to poly (dA-dT).poly(dA-dT) suggested that there are at least two different binding domains in the protein and that binding is not dependent upon an intact protein. ..
  48. Miranda T, Webb K, Edberg D, Reeves R, Clarke S. Protein arginine methyltransferase 6 specifically methylates the nonhistone chromatin protein HMGA1a. Biochem Biophys Res Commun. 2005;336:831-5 pubmed
    The HMGA family proteins HMGA1a and HMGA1b are nuclear nonhistone species implicated in a wide range of cellular processes including inducible gene transcription, modulation of chromosome structure through nucleosome and chromosome ..
  49. Larsson L, Jäwert F, Magnusson B, Hassèus B, Kjeller G. Expression of high mobility group A proteins in oral leukoplakia. Anticancer Res. 2013;33:4261-6 pubmed
    ..Biopsies were histologically processed to visualize the expression of HMGA1 and HMGA2 using immunohistochemistry...
  50. Pellarin I, Arnoldo L, Costantini S, Pegoraro S, Ros G, Penzo C, et al. The Architectural Chromatin Factor High Mobility Group A1 Enhances DNA Ligase IV Activity Influencing DNA Repair. PLoS ONE. 2016;11:e0164258 pubmed publisher
    The HMGA1 architectural transcription factor is an oncogene overexpressed in the vast majority of human cancers...
  51. Sgarra R, Pegoraro S, Ros G, Penzo C, Chiefari E, Foti D, et al. High Mobility Group A (HMGA) proteins: Molecular instigators of breast cancer onset and progression. Biochim Biophys Acta Rev Cancer. 2018;1869:216-229 pubmed publisher
    ..The High Mobility Group A (HMGA) chromatin architectural factors (HMGA1a, HMGA1b, and HMGA2) have a relevant and causal role in breast cancer onset and development, by influencing ..
  52. Zhong J, Liu C, Zhang Q, Chen L, Shen Y, Chen Y, et al. TGF-?1 induces HMGA1 expression: The role of HMGA1 in thyroid cancer proliferation and invasion. Int J Oncol. 2017;50:1567-1578 pubmed publisher
    ..High mobility group A (HMGA1) participates in multiple cellular biology processes, and exerts important roles in the epithelial-mesenchymal ..
  53. Kim D, Seo E, Choi E, Lee S, Kwon Y, Jang I, et al. Crucial role of HMGA1 in the self-renewal and drug resistance of ovarian cancer stem cells. Exp Mol Med. 2016;48:e255 pubmed publisher
    ..The aim of this study was to investigate the role of HMGA1, a chromatin remodeling factor abundantly expressed in many different cancers, in the regulation of cancer stem ..
  54. Dey D, Bhattacharya A, Roy S, Bhattacharya S. Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Cepsilon. Biochem Biophys Res Commun. 2007;357:474-9 pubmed
    ..Experimental evidences indicate that phospho-PKCepsilon adversely affected HMGA1. Since HMGA1 regulates IR promoter activity, expression of IR gene was impaired causing reduction of IR on cell ..
  55. Pierantoni G, Conte A, Rinaldo C, Tornincasa M, Gerlini R, Federico A, et al. Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes. Oncotarget. 2015;6:17342-53 pubmed
    ..Herein we identify the nonhistone architectural nuclear proteins High Mobility Group A1 (HMGA1), whose overexpression is a feature of several human malignancies and has a key role in cancer progression, as ..
  56. Bonfiglio J, Fontana P, Zhang Q, Colby T, Gibbs Seymour I, Atanassov I, et al. Serine ADP-Ribosylation Depends on HPF1. Mol Cell. 2017;65:932-940.e6 pubmed publisher
    ..We propose that O-linked protein ADPr is the key signal in PARP-1/PARP-2-dependent processes that govern genome stability. ..
  57. Forzati F, Federico A, Pallante P, Abbate A, Esposito F, Malapelle U, et al. CBX7 is a tumor suppressor in mice and humans. J Clin Invest. 2012;122:612-23 pubmed publisher
    ..These data suggest that CBX7 is a tumor suppressor and that its loss plays a key role in the pathogenesis of cancer. ..
  58. Bianco A, Chiefari E, Nobile C, Foti D, Pavia M, Brunetti A. The Association between HMGA1 rs146052672 Variant and Type 2 Diabetes: A Transethnic Meta-Analysis. PLoS ONE. 2015;10:e0136077 pubmed publisher
    The high-mobility group A1 (HMGA1) gene has been previously identified as a potential novel candidate gene for susceptibility to insulin resistance and type 2 diabetes (T2D) mellitus...
  59. Sepe R, Piscuoglio S, Quintavalle C, Perrina V, Quagliata L, Formisano U, et al. HMGA1 overexpression is associated with a particular subset of human breast carcinomas. J Clin Pathol. 2016;69:117-21 pubmed publisher
    ..High-mobility group A1 (HMGA1) expression has been implicated in the pathogenesis and progression of human malignant tumours, including breast ..
  60. Zhou J, Xie M, He H, Shi Y, Luo B, Gong G, et al. Increases urinary HMGA1 in serous epithelial ovarian cancer patients. Cancer Biomark. 2015;15:325-31 pubmed publisher
    ..b>HMGA1 a small 10...
  61. Giannini G, Kim C, Di Marcotullio L, Manfioletti G, Cardinali B, Cerignoli F, et al. Expression of the HMGI(Y) gene products in human neuroblastic tumours correlates with differentiation status. Br J Cancer. 2000;83:1503-9 pubmed
  62. Maurizio E, Wiśniewski J, Ciani Y, Amato A, Arnoldo L, Penzo C, et al. Translating Proteomic Into Functional Data: An High Mobility Group A1 (HMGA1) Proteomic Signature Has Prognostic Value in Breast Cancer. Mol Cell Proteomics. 2016;15:109-23 pubmed publisher
    ..b>HMGA1 protein has this unique property because it is a master regulator in breast cancer cells that control the ..
  63. De Martino M, Forzati F, Arra C, Fusco A, Esposito F. HMGA1-pseudogenes and cancer. Oncotarget. 2016;7:28724-35 pubmed publisher
    ..Here, we concentrate our attention on the pseudogenes of the HMGA1 gene, that codes for the HMGA1a and HMGA1b proteins having a critical role in development and cancer progression...
  64. Liu S, Jiang R, Wang W, Lin J. Somatic mutations in the D-loop of mitochondrial DNA in head and neck squamous cell carcinoma. Head Neck. 2015;37:878-83 pubmed publisher
    ..Patients with D-loop mutations had better survival (4-year disease-specific survival rate: 70.5% vs 50.8%; p = .0435). Somatic mutation of D-loop of mtDNA was a potential prognostic factor of head and neck squamous cell carcinoma. ..
  65. Cheung C, Hsu C, Chen K, Chong S, Wu C, Huang H, et al. MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach. Sci Rep. 2017;7:13302 pubmed publisher
    ..Furthermore, HMGA1S99 phosphorylation was found to be differentially expressed under MCM2 perturbation in opposite ..
  66. Eilebrecht S, Bécavin C, Leger H, Benecke B, Benecke A. HMGA1-dependent and independent 7SK RNA gene regulatory activity. RNA Biol. 2011;8:143-57 pubmed
    ..7SK RNA has recently been shown to also directly control HMGA1 transcription activity...