Gene Symbol: HMG20A
Description: high mobility group 20A
Alias: HMGX1, HMGXB1, high mobility group protein 20A, HMG box domain containing 1, HMG box-containing protein 20A, HMG domain-containing protein 1, HMG domain-containing protein HMGX1
Species: human
Products:     HMG20A

Top Publications

  1. McClellan D, Casey M, Bareyan D, Lucente H, Ours C, Velinder M, et al. Growth Factor Independence (GFI) 1B-mediated transcriptional repression and lineage allocation require Lysine Specific Demethylase (LSD)1-dependent recruitment of the BHC complex. Mol Cell Biol. 2019;: pubmed publisher
    ..core and putative elements of the BRAF-histone deacetylase (HDAC) (BHC) chromatin remodeling complex (LSD1, RCOR1, HMG20A, HMG20B, HDAC1, HDAC2, PHF21A, GSE1, ZMYM2 and ZNF217) in an LSD1-dependent manner to control acquisition of ..
  2. Harder M, Ribel Madsen R, Justesen J, Sparsø T, Andersson E, Grarup N, et al. Type 2 diabetes risk alleles near BCAR1 and in ANK1 associate with decreased β-cell function whereas risk alleles near ANKRD55 and GRB14 associate with decreased insulin sensitivity in the Danish Inter99 cohort. J Clin Endocrinol Metab. 2013;98:E801-6 pubmed publisher
    ..susceptibility single nucleotide polymorphisms (SNPs) in ZMIZ1, ANK1, KLHDC5, TLE1, ANKRD55, CILP2, MC4R, BCAR1, HMG20A, and GRB14 loci were discovered in MetaboChip-genotyped populations of European ancestry...
  3. Locke J, Hysenaj G, Wood A, Weedon M, Harries L. Targeted allelic expression profiling in human islets identifies cis-regulatory effects for multiple variants identified by type 2 diabetes genome-wide association studies. Diabetes. 2015;64:1484-91 pubmed publisher
    ..A significant allelic expression imbalance (AEI) was identified for 7/14 (50%) genes tested (ANPEP, CAMK2B, HMG20A, KCNJ11, NOTCH2, SLC30A8, and WFS1), with significant AEI confirmed for five of these genes using other linked ..
  4. Shabana -, Shahid S, Hasnain S. Use of a gene score of multiple low-modest effect size variants can predict the risk of obesity better than the individual SNPs. Lipids Health Dis. 2018;17:155 pubmed publisher
    ..rs1802295 in Vacuolar protein sorting-associated protein 26A (VPS26A), rs7178572 in high mobility group 20A (HMG20A), rs2028299 in adaptor-related protein complex 3 (AP3S2), and rs4812829 in Hepatocyte Nuclear Factor 4 Alpha (..
  5. Sarker N, Fabijan J, Emes R, Hemmatzadeh F, Meers J, Moreton J, et al. Identification of stable reference genes for quantitative PCR in koalas. Sci Rep. 2018;8:3364 pubmed publisher
    ..All 13 genes showed relative stability in expression in koala lymph node tissues, however Tmem97 and Hmg20a were identified as the most stable genes across the two koala populations.
  6. Fatima S, Wagstaff K, Lieu K, Davies R, Tanaka S, Yamaguchi Y, et al. Interactome of the inhibitory isoform of the nuclear transporter Importin 13. Biochim Biophys Acta Mol Cell Res. 2017;1864:546-561 pubmed publisher
    ..tImp13 with Eukaryotic translation initiation factor 4?2 (EIF4G2) and High mobility group containing protein 20A (HMG20A), benchmarking that with glucocorticoid receptor (GR), a known Imp13 interactor expressed in testis...
  7. Kanthimathi S, Chidambaram M, Bodhini D, Liju S, Bhavatharini A, Uma R, et al. Association of recently identified type 2 diabetes gene variants with Gestational Diabetes in Asian Indian population. Mol Genet Genomics. 2017;292:585-591 pubmed publisher
    ..loci, namely AP3S2 (rs2028299), BAZ1B (rs12056034), CDKN2A/B (rs7020996), GRB14 (rs3923113), HHEX (rs7923837), HMG20A (rs7178572), HNF4A (rs4812829), ST6GAL1 (rs16861329) and VPS26A (rs1802295) were genotyped using the MassARRAY ..
  8. Xu K, Jiang L, Zhang M, Zheng X, Gu Y, Wang Z, et al. Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals. Medicine (Baltimore). 2016;95:e3604 pubmed publisher
    Recently, rs163182 in KCNQ1, rs7612463 in UBE2E2, rs7119 in HMG20A, and rs6815464 in MAEA were discovered as type 2 diabetes (T2D) loci unique to Asians, and rs13342692 in SLC16A11 were newly reported as T2D loci in multiethnicities by ..
  9. Mellado Gil J, Fuente Martín E, Lorenzo P, Cobo Vuilleumier N, López Noriega L, Martín Montalvo A, et al. The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. Cell Death Dis. 2018;9:279 pubmed publisher
    b>HMG20A (also known as iBRAF) is a chromatin factor involved in neuronal differentiation and maturation...

More Information


  1. Davies R, Wagstaff K, McLaughlin E, Loveland K, Jans D. The BRCA1-binding protein BRAP2 can act as a cytoplasmic retention factor for nuclear and nuclear envelope-localizing testicular proteins. Biochim Biophys Acta. 2013;1833:3436-3444 pubmed publisher
    ..for the first time of three of these: the high mobility group (HMG)-box-domain-containing chromatin component HMG20A, nuclear mitotic apparatus protein NuMA1 and synaptic nuclear envelope protein SYNE2...
  2. Sumoy L, Carim L, Escarceller M, Nadal M, Gratacos M, Pujana M, et al. HMG20A and HMG20B map to human chromosomes 15q24 and 19p13.3 and constitute a distinct class of HMG-box genes with ubiquitous expression. Cytogenet Cell Genet. 2000;88:62-7 pubmed
    ..We describe HMG20A and HMG20B, two novel human HMG box-containing genes, discovered within the EURO-IMAGE Consortium full-length cDNA ..
  3. Zheng W, Dong X, Yin R, Xu F, Ning H, Zhang M, et al. EDAG positively regulates erythroid differentiation and modifies GATA1 acetylation through recruiting p300. Stem Cells. 2014;32:2278-89 pubmed publisher
    ..Microarray analysis suggested that EDAG knockdown selectively inhibits GATA1-activated target genes. These data provide novel insights into EDAG in regulation of erythroid differentiation. ..
  4. Shabana -, Ullah Shahid S, Wah Li K, Acharya J, Cooper J, Hasnain S, et al. Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects. Eur J Hum Genet. 2016;24:903-10 pubmed publisher
    ..effect of six type II diabetes GWAS loci rs3923113 (GRB14), rs16861329 (ST6GAL1), rs1802295 (VPS26A), rs7178572 (HMG20A), rs2028299 (AP3S2) and rs4812829 (HNF4A), and an FTO polymorphism (rs9939609) on obesity...
  5. Rivero S, Ceballos Chávez M, Bhattacharya S, Reyes J. HMG20A is required for SNAI1-mediated epithelial to mesenchymal transition. Oncogene. 2015;34:5264-76 pubmed publisher
    b>HMG20A is a high mobility group (HMG) domain containing protein homologous to HMG20B, a core subunit of the Lys-specific demethylase 1/REST co-repressor 1 (LSD1-CoREST) histone demethylase complex...
  6. Perry J, Voight B, Yengo L, Amin N, Dupuis J, Ganser M, et al. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. PLoS Genet. 2012;8:e1002741 pubmed publisher
    ..04, OR = 1.03 [95% CI 1.00-1.06]). A variant in HMG20A--previously identified in South Asians but not Europeans--was associated with type 2 diabetes in obese cases (Pâ..
  7. Ceballos Chávez M, Rivero S, García Gutiérrez P, Rodríguez Paredes M, Garcia Dominguez M, Bhattacharya S, et al. Control of neuronal differentiation by sumoylation of BRAF35, a subunit of the LSD1-CoREST histone demethylase complex. Proc Natl Acad Sci U S A. 2012;109:8085-90 pubmed publisher
    ..Our data uncover a mechanism of regulation of the LSD1-CoREST complex and provide a molecular explanation for the antagonism between Braf35 and iBraf in neuronal differentiation. ..
  8. Kooner J, Saleheen D, Sim X, Sehmi J, Zhang W, Frossard P, et al. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. Nat Genet. 2011;43:984-9 pubmed publisher
    ..In the combined analysis, we identified common genetic variants at six loci (GRB14, ST6GAL1, VPS26A, HMG20A, AP3S2 and HNF4A) newly associated with T2D (P = 4.1 × 10(-8) to P = 1.9 × 10(-11))...
  9. Sim X, Ong R, Suo C, Tay W, Liu J, Ng D, et al. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. PLoS Genet. 2011;7:e1001363 pubmed publisher
    ..These findings highlight the value of surveying across diverse racial/ethnic groups towards the fine-mapping efforts for the casual variants and also of the search for variants, which may be population-specific. ..
  10. Nicolas E, Poitelon Y, Chouery E, Salem N, Levy N, M garban A, et al. CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592. Eur J Hum Genet. 2010;18:1107-13 pubmed publisher
  11. Artegiani B, Labbaye C, Sferra A, Quaranta M, Torreri P, Macchia G, et al. The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation. J Biol Chem. 2010;285:24740-50 pubmed publisher
    ..Among the positive clones, one encodes iBRAF/HMG20a, a high mobility group (HMG)-domain protein that activates REST (RE-1 silencing transcription factor)-responsive ..
  12. Shi Y, Matson C, Lan F, Iwase S, Baba T, Shi Y. Regulation of LSD1 histone demethylase activity by its associated factors. Mol Cell. 2005;19:857-64 pubmed
    ..Taken together, these findings suggest that LSD1-mediated histone demethylation is regulated dynamically in vivo. This is expected to have profound effects on gene expression under both physiological and pathological conditions. ..