HLA-DRB1

Summary

Gene Symbol: HLA-DRB1
Description: major histocompatibility complex, class II, DR beta 1
Alias: DRB1, HLA-DR1B, HLA-DRB, SS1, major histocompatibility complex, class II, DR beta 1, HLA class II histocompatibility antigen, DR-1 beta chain, MHC class II HLA-DR beta 1 chain, human leucocyte antigen DRB1, lymphocyte antigen DRB1
Species: human
Products:     HLA-DRB1

Top Publications

  1. Feitsma A, Worthington J, van der Helm van Mil A, Plant D, Thomson W, Ursum J, et al. Protective effect of noninherited maternal HLA-DR antigens on rheumatoid arthritis development. Proc Natl Acad Sci U S A. 2007;104:19966-70 pubmed
    ..HLA-DRB1-molecules containing the amino acid sequence DERAA (i.e...
  2. van der Walt A, Stankovich J, Bahlo M, Taylor B, van der Mei I, Foote S, et al. Heterogeneity at the HLA-DRB1 allelic variation locus does not influence multiple sclerosis disease severity, brain atrophy or cognition. Mult Scler. 2011;17:344-52 pubmed publisher
    HLA-DRB1*1501 (DR15) and other HLA class II alleles increase the risk of developing multiple sclerosis (MS). However, the contribution of genetic heterogeneity to the clinical course of MS remains controversial...
  3. Galeazzi M, Sebastiani G, Morozzi G, Carcassi C, Ferrara G, Scorza R, et al. HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets. Medicine (Baltimore). 2002;81:169-78 pubmed
  4. Howson J, Walker N, Clayton D, Todd J. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab. 2009;11 Suppl 1:31-45 pubmed publisher
    ..4 Mb), HLA-A (at 30.0 Mb) are associated with T1D independently of the class II genes HLA-DRB1 and HLA-DQB1 (P = 6.0 x 10(-17) and 8.8 x 10(-13), respectively)...
  5. Cangussu L, Teixeira R, Campos E, Rampim G, Mingoti S, Martins Filho O, et al. HLA class II alleles and chronic hepatitis C virus infection. Scand J Immunol. 2011;74:282-287 pubmed publisher
    The aim of this study was to investigate association of human leucocyte antigens (HLA)-DRB1 and DQB1 polymorphisms with hepatitis C virus (HCV) infection and with the occurrence of severe liver fibrosis/cirrhosis in chronically infected ..
  6. Kanagawa S, Morinobu A, Koshiba M, Kageyama G, Hayashi N, Yoshino S, et al. Association of the TAP2*Bky2 allele with presence of SS-A/Ro and other autoantibodies in Japanese patients with systemic lupus erythematosus. Lupus. 2003;12:258-65 pubmed
    ..As TAP2*Bky2 had a strong linkage disequilibrium with DRB1*08032, TAP2*Bky2 or its haplotype with DRB1*08032 may be involved in SS-A/Ro antibody production not only in SS but ..
  7. Field J, Browning S, Johnson L, Danoy P, Varney M, Tait B, et al. A polymorphism in the HLA-DPB1 gene is associated with susceptibility to multiple sclerosis. PLoS ONE. 2010;5:e13454 pubmed publisher
    ..The associated SNPs included proxies for HLA-DRB1*15:01 and HLA-DRB1*03:01, and SNPs in moderate linkage disequilibrium (LD) with HLA-A*02:01, HLA-DRB1*04:01 and HLA-..
  8. Runstadler J, Saila H, Savolainen A, Leirisalo Repo M, Aho K, Tuomilehto Wolf E, et al. HLA-DRB1, TAP2/TAP1, and HLA-DPB1 haplotypes in Finnish juvenile idiopathic arthritis: more complexity within the MHC. Genes Immun. 2004;5:562-71 pubmed
    This study further defines genetic susceptibility to JIA in the region centromeric to HLA-DRB1. DNA from 234 Finnish JIA nuclear families and 639 elderly Finnish control individuals was genotyped for five functional SNPs within the TAP2 ..
  9. Ramagopalan S, Maugeri N, Handunnetthi L, Lincoln M, Orton S, Dyment D, et al. Expression of the multiple sclerosis-associated MHC class II Allele HLA-DRB1*1501 is regulated by vitamin D. PLoS Genet. 2009;5:e1000369 pubmed publisher
    ..Sequence analysis localised a single MHC vitamin D response element (VDRE) to the promoter region of HLA-DRB1. Sequencing of this promoter in greater than 1,000 chromosomes from HLA-DRB1 homozygotes showed absolute ..

More Information

Publications97

  1. Cree B, Rioux J, McCauley J, Gourraud P, Goyette P, McElroy J, et al. A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. PLoS ONE. 2010;5:e11296 pubmed publisher
    ..for multiple sclerosis (MS) is associated with alleles of the human leukocyte antigen (HLA) Class II gene DRB1. Whether other major histocompatibility complex (MHC) genes contribute to MS susceptibility is controversial...
  2. Xiao X, Liu L, Li W, Liu J, Chen D. HLA-A, HLA-B, HLA-DRB1 polymorphisms and risk of cervical squamous epithelial cell carcinoma: a population study in China. Asian Pac J Cancer Prev. 2013;14:4427-33 pubmed
    ..In this study, the HLA-A, -B, and -DRB1 alleles among 100 southern Chinese women with cervical squamous cell carcinoma (SCC) were compared to 254 controls...
  3. Qin Qin P, Su F, Xiao yan W, Xing Z, Meng P, Chengya W, et al. Distribution of human leucocyte antigen-A, -B and -DR alleles and haplotypes at high resolution in the population from Jiangsu province of China. Int J Immunogenet. 2011;38:475-81 pubmed publisher
    The frequencies of human leucocyte antigen (HLA)-A, -B and -DRB1 alleles and haplotypes were statistically analysed among 3238 donors from Chinese Marrow Donor Program (CMDP) Jiangsu Branch...
  4. Alaez Verson C, Berumen Campos J, Munguía Saldaña A, Flores Aguilar H, Guardado Estrada M, Rodríguez Gomez A, et al. HPV-16 and HLA-DRB1 alleles are associated with cervical carcinoma in Mexican Mestizo women. Arch Med Res. 2011;42:421-5 pubmed publisher
    The aim of this report was to investigate the contribution of HLA-DRB1/DQB1 alleles to the expression of cervical cancer (CC) and squamous intraepithelial lesion (SIL) in Mexican patients...
  5. Balnytė R, Rastenyte D, Uloziene I, Mickeviciene D, Skordenienė E, Vitkauskiene A. The significance of HLA DRB1*1501 and oligoclonal bands in multiple sclerosis: clinical features and disability. Medicina (Kaunas). 2011;47:368-73 pubmed
    ..b>HLA DRB1 alleles were genotyped using polymerase chain reaction...
  6. Jelcic I, Aly L, Binder T, Jelcić I, Bofill Mas S, Planas R, et al. T cell epitope mapping of JC polyoma virus-encoded proteome reveals reduced T cell responses in HLA-DRB1*04:01+ donors. J Virol. 2013;87:3393-408 pubmed publisher
    ..Four immunodominant peptides were mapped, and at least one immunogenic peptide per HLA-DRB1 allele was detected in DRB1*01(+), DRB1*07(+), DRB1*11(+), DRB1*13(+), DRB1*15(+), and DRB1*03(+) individuals...
  7. Balnytė R, Rastenyte D, Mickeviciene D, Vaitkus A, Skrodeniene E, Vitkauskiene A. Frequency of HLA-DRB1 gene alleles in patients with multiple sclerosis in a Lithuanian population. Medicina (Kaunas). 2012;48:9-14 pubmed
    The aim of the present study was to investigate the influence of HLA-DRB1 alleles on the genetic susceptibility to multiple sclerosis in the Lithuanian population. MATERIAL AND METHODS...
  8. Cozen W, Li D, Best T, Van Den Berg D, Gourraud P, Cortessis V, et al. A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32. Blood. 2012;119:469-75 pubmed publisher
    ..4, P = 1.16 × 10(-4)). All individuals with the GAATC haplotype also carried the HLA class II DRB1*0701 allele. In a separate analysis, the DRB1*0701 allele was associated with a decreased risk of NSHL (OR = 0...
  9. Rubicz R, Yolken R, DRIGALENKO E, Carless M, Dyer T, Bauman L, et al. A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). PLoS Genet. 2013;9:e1003147 pubmed publisher
    ..of at least two separate loci within MHC class II, and along with lymphocyte expression data suggest genes HLA-DRB1 and HLA-DQB1 as the best candidates...
  10. Louthrenoo W, Kasitanon N, Wichainun R, Wangkaew S, Sukitawut W, Ohnogi Y, et al. Association of HLA-DRB1*15:02 and DRB5*01:02 allele with the susceptibility to systemic sclerosis in Thai patients. Rheumatol Int. 2013;33:2069-77 pubmed publisher
    ..1%, Pc = 0.0018). Among the HLA-DR*15 alleles, the AF of the DRB1*15:02 was increased significantly in all SSc patients (29.0 vs 12.6%, Pc = 0...
  11. Shimane K, Kochi Y, Suzuki A, Okada Y, Ishii T, Horita T, et al. An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. Rheumatology (Oxford). 2013;52:1172-82 pubmed publisher
    Objective. To re-evaluate the roles of HLA-DRB1 alleles in susceptibility to SLE and RA and their effects on autoantibody status in large-scale Japanese cohorts. Methods...
  12. Chen D, Juko Pecirep I, Hammer J, Ivansson E, Enroth S, Gustavsson I, et al. Genome-wide association study of susceptibility loci for cervical cancer. J Natl Cancer Inst. 2013;105:624-33 pubmed publisher
    ..42, 95% CI = 1.31 to 1.54; P = 1.6×10(-18)); the second is between HLA-DRB1 and HLA-DQA1 (rs9272143; OR = 0.67, 95% CI = 0.62 to 0.72; P = 9...
  13. Gorlova O, Martin J, Rueda B, Koeleman B, Ying J, Teruel M, et al. Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy. PLoS Genet. 2011;7:e1002178 pubmed publisher
    ..Within the HLA region, HLA-DQB1, HLA-DPA1/B1, and NOTCH4 associations with SSc are likely confined to specific auto-antibodies. These data emphasize the differential genetic components of subphenotypes of SSc. ..
  14. Zhao M, Qiu L, Tao N, Zhang L, She Q, Zeng F, et al. HLA DRB allele polymorphisms and risk of cervical cancer associated with human papillomavirus infection: a population study in China. Eur J Gynaecol Oncol. 2013;34:54-9 pubmed
    ..HLA-DRB1*13 (OR = 4.01 95% CI, 1.703-9.442) and HLA-DRB1*3(17) (OR = 2.661 95% CI, 1.267-5...
  15. Matsumoto K, Maeda H, Oki A, Takatsuka N, Yasugi T, Furuta R, et al. HLA class II DRB1*1302 allele protects against progression to cervical intraepithelial neoplasia grade 3: a multicenter prospective cohort study. Int J Gynecol Cancer. 2012;22:471-8 pubmed publisher
    ..Progression to CIN3 did not occur in DRB1*1302-positive women, and this protective effect of DRB1*1302 was statistically significant (P = 0.03)...
  16. Fakiola M, Strange A, Cordell H, Miller E, Pirinen M, Su Z, et al. Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis. Nat Genet. 2013;45:208-13 pubmed publisher
    ..The HLA-DRB1-HLA-DQA1 locus was the only region to show strong evidence of association in both populations...
  17. Sayad A, Akbari M, Pajouhi M, Mostafavi F, Zamani M. The influence of the HLA-DRB, HLA-DQB and polymorphic positions of the HLA-DR?1 and HLA-DQ?1 molecules on risk of Iranian type 1 diabetes mellitus patients. Int J Immunogenet. 2012;39:429-36 pubmed publisher
    Type 1 Diabetes mellitus (T1D) is an autoimmune and multifactorial disease. HLA-DRB1 and DQB1 loci have the strongest association with T1D...
  18. Mackie S, Taylor J, Martin S, Wordsworth P, Steer S, Wilson A, et al. A spectrum of susceptibility to rheumatoid arthritis within HLA-DRB1: stratification by autoantibody status in a large UK population. Genes Immun. 2012;13:120-8 pubmed publisher
    Previously-proposed rheumatoid arthritis (RA) HLA-DRB1 susceptibility and protective models were compared, based on amino acids at positions 67-74 and autoantibody combinations...
  19. Alaez C, Flores A H, Concha Del Río L, Munguia A, Rodríguez A, Garcia D, et al. Major histocompatibility complex and strong human leukocyte antigen-DRB1 and gender association with Vogt-Koyanagi-Harada syndrome in Mexican Mestizos. Hum Immunol. 2011;72:1198-203 pubmed publisher
    ..A strong major histocompatibility complex (MHC) association with HLA-DRB1*04:05 has been demonstrated in different populations...
  20. Achkar J, Klei L, de Bakker P, Bellone G, Rebert N, Scott R, et al. Amino acid position 11 of HLA-DR?1 is a major determinant of chromosome 6p association with ulcerative colitis. Genes Immun. 2012;13:245-52 pubmed publisher
    ..Taken together, these data demonstrate that variation at HLA-DR?1, amino acid 11 in the P6 pocket of the HLA-DR complex antigen binding cleft is a major determinant of chromosome 6p association with UC. ..
  21. Cocco E, Sardu C, Pieroni E, Valentini M, Murru R, Costa G, et al. HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia. PLoS ONE. 2012;7:e33972 pubmed publisher
    Genetic predisposition to multiple sclerosis (MS) in Sardinia (Italy) has been associated with five DRB1*-DQB1* haplotypes of the human leukocyte antigen (HLA)...
  22. Ben Othmane Y, Ghazouani E, Mezlini A, Lagha A, Raïs M, Kochkar R, et al. HLA class II susceptibility to cervical cancer among Tunisian women. Bull Cancer. 2012;99:81-6 pubmed publisher
    ..we conducted a case-control study in Tunisian women to examine the effect of genetic variation in HLA class II DRB1 and DQB1 genes on invasive cervical cancer (ICC) and squamous cell carcinoma (SCC)...
  23. Rojana udomsart A, James I, Castley A, Needham M, Scott A, Day T, et al. High-resolution HLA-DRB1 genotyping in an Australian inclusion body myositis (s-IBM) cohort: an analysis of disease-associated alleles and diplotypes. J Neuroimmunol. 2012;250:77-82 pubmed publisher
    We performed high-resolution (4-digit) HLA-DRB1 genotyping in an Australian cohort of 105s-IBM patients and 189 controls...
  24. Painter C, Negroni M, Kellersberger K, Zavala Ruiz Z, Evans J, Stern L. Conformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchange. Proc Natl Acad Sci U S A. 2011;108:19329-34 pubmed publisher
  25. Kuranov A, Kozhamkulov U, Vavilov M, Belova E, Bismilda V, Alenova A, et al. HLA-class II alleles in patients with drug-resistant pulmonary tuberculosis in Kazakhstan. Tissue Antigens. 2014;83:106-12 pubmed publisher
    ..HLA-DQA1*03:02 HLA-DRB1*08:01 and DRB1*08:03 occurred more frequently (P?=?0...
  26. Raychaudhuri S, Sandor C, Stahl E, Freudenberg J, Lee H, Jia X, et al. Five amino acids in three HLA proteins explain most of the association between MHC and seropositive rheumatoid arthritis. Nat Genet. 2012;44:291-6 pubmed publisher
    ..major histocompatibility complex (MHC) to rheumatoid arthritis risk has commonly been attributed to alleles in HLA-DRB1. However, debate persists about the identity of the causal variants in HLA-DRB1 and the presence of independent ..
  27. Bäärnhielm M, Hedström A, Kockum I, Sundqvist E, Gustafsson S, Hillert J, et al. Sunlight is associated with decreased multiple sclerosis risk: no interaction with human leukocyte antigen-DRB1*15. Eur J Neurol. 2012;19:955-62 pubmed publisher
    ..An interaction between human leukocyte antigen HLA-DRB1*15 and vitamin D in MS was recently proposed...
  28. De la Concha E, Cavanillas M, Cénit M, Urcelay E, Arroyo R, Fernandez O, et al. DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands. PLoS ONE. 2012;7:e31018 pubmed publisher
    ..However, except for the DRB1*15:01 allele, the main risk factor associated to MS so far, no consistent effect has been described for any other ..
  29. Khani Hanjani A, Lacaille D, Horne C, Chalmers A, Hoar D, Balshaw R, et al. Expression of QK/QR/RRRAA or DERAA motifs at the third hypervariable region of HLA-DRB1 and disease severity in rheumatoid arthritis. J Rheumatol. 2002;29:1358-65 pubmed
    ..HRE) QK/QR/RRRAA or the low risk epitope (LRE) DERAA at positions 70-74 of the third hypervariable region of HLA-DRB1. A case-control design to compare allele carriage rates in 204 Caucasian subjects with severe RA and mild RA and ..
  30. Vignal C, Bansal A, Balding D, Binks M, Dickson M, Montgomery D, et al. Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. Arthritis Rheum. 2009;60:53-62 pubmed publisher
    The HLA-DRB1 locus within the major histocompatibility complex (MHC) at 6p21...
  31. van Gaalen F, van Aken J, Huizinga T, Schreuder G, Breedveld F, Zanelli E, et al. Association between HLA class II genes and autoantibodies to cyclic citrullinated peptides (CCPs) influences the severity of rheumatoid arthritis. Arthritis Rheum. 2004;50:2113-21 pubmed
    ..Carriership of the individual alleles HLA-DRB1*0401, DRB1*1001, DQB1*0302, and DQB1*0501 was associated with the presence of anti-CCP antibodies...
  32. Mack S, Tu B, Lazaro A, Yang R, Lancaster A, Cao K, et al. HLA-A, -B, -C, and -DRB1 allele and haplotype frequencies distinguish Eastern European Americans from the general European American population. Tissue Antigens. 2009;73:17-32 pubmed publisher
    Sequence-based typing was used to identify human leukocyte antigen (HLA)-A, -B, -C, and -DRB1 alleles from 558 consecutively recruited US volunteers with Eastern European ancestry for an unrelated hematopoietic stem cell registry...
  33. Smestad C, Brynedal B, Jonasdottir G, Lorentzen A, Masterman T, Akesson E, et al. The impact of HLA-A and -DRB1 on age at onset, disease course and severity in Scandinavian multiple sclerosis patients. Eur J Neurol. 2007;14:835-40 pubmed
    The human leucocyte antigen (HLA) class II haplotype DRB1*15-DQB1*06 (DR15-DQ6) is associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS have also been reported...
  34. Lincoln M, Montpetit A, Cader M, Saarela J, Dyment D, Tiislar M, et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet. 2005;37:1108-12 pubmed
    ..to multiple sclerosis is associated with genes of the major histocompatibility complex (MHC), particularly HLA-DRB1 and HLA-DQB1 (ref. 1). Both locus and allelic heterogeneity have been reported in this genomic region...
  35. Erlich H, Valdes A, Noble J, Carlson J, Varney M, Concannon P, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes. 2008;57:1084-92 pubmed publisher
    ..The major genetic determinants of type 1 diabetes are alleles at the HLA-DRB1 and DQB1 loci, with both susceptible and protective DR-DQ haplotypes present in all human populations...
  36. Ovsyannikova I, Pankratz V, Vierkant R, Jacobson R, Poland G. Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. J Infect Dis. 2006;193:655-63 pubmed
    ..02) and mumps (P=.01) vaccine viruses. Subjects with the class II DRB1*03-DQB1*02-DPB1*04 haplotype had higher lymphoproliferative responses to measles virus (P=.01) and mumps virus (P=...
  37. Tang J, Penman Aguilar A, Lobashevsky E, Allen S, Kaslow R. HLA-DRB1 and -DQB1 alleles and haplotypes in Zambian couples and their associations with heterosexual transmission of HIV type 1. J Infect Dis. 2004;189:1696-704 pubmed
    In 292 initially human immunodeficiency virus (HIV)-1-serodiscordant and cohabiting Zambian couples, HLA-DRB1 and -DQB1 variants were associated with HIV-1 transmission events during a 7-year follow-up period...
  38. Nagore E, Planelles M, Ledesma E, Millan J, Insa A, Oliver V, et al. Molecular genetic analysis of HLA-DR and -DQ alleles in Spanish patients with melanoma. Acta Derm Venereol. 2002;82:90-3 pubmed
    ..Our results indicate that HLA class II alleles may not contribute to a strong susceptibility to melanoma in the Spanish population, although further studies on larger series are needed to corroborate this. Key words: ..
  39. Hermann R, Laine A, Veijola R, Vahlberg T, Simell S, Lähde J, et al. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. Diabetologia. 2005;48:1766-75 pubmed
    ..The appearance of IAA showed a strong association also with the HLA DRB1*0401 allele (hazard ratio 13.1, 95% CI 1.8-93.4, p<0.001)...
  40. Thomson W, Barton A, Ke X, Eyre S, Hinks A, Bowes J, et al. Rheumatoid arthritis association at 6q23. Nat Genet. 2007;39:1431-3 pubmed
    ..1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3). ..
  41. Taneja V, Behrens M, Basal E, Sparks J, Griffiths M, Luthra H, et al. Delineating the role of the HLA-DR4 "shared epitope" in susceptibility versus resistance to develop arthritis. J Immunol. 2008;181:2869-77 pubmed
    In humans, HLA-DR alleles sharing amino acids at the third hypervariable region with DRB1*0401(shared epitope) are associated with a predisposition to rheumatoid arthritis, whereas DRB1*0402 is not associated with such a predisposition...
  42. Valdes A, Thomson G. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab. 2009;11 Suppl 1:46-52 pubmed publisher
    Several studies have indicated that genes in the human leucocyte antigen (HLA) region additional to the HLA class II DRB1-DQB1 contribute to type 1 diabetes (T1D) susceptibility...
  43. Zhang S, Gu H, Li D, Yang S, Zhong Z, Li X, et al. Association of human leukocyte antigen polymorphism with hepatitis B virus infection and genotypes. Jpn J Infect Dis. 2006;59:353-7 pubmed
    ..HLA-A, B, and DRB1 alleles in peripheral blood mononuclear cells (PBMCs) were detected by polymerase chain reaction (PCR) with ..
  44. Invernizzi P, Selmi C, Poli F, Frison S, Floreani A, Alvaro D, et al. Human leukocyte antigen polymorphisms in Italian primary biliary cirrhosis: a multicenter study of 664 patients and 1992 healthy controls. Hepatology. 2008;48:1906-12 pubmed publisher
    ..We performed a multicenter case-control study and analyzed HLA class II DRB1 associations using a large cohort of 664 well-defined cases of PBC and 1992 controls of Italian ancestry...
  45. Uinuk ool T, Takezaki N, Sukernik R, Nagl S, Klein J. Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies. Hum Genet. 2002;110:209-26 pubmed
    ..Buryat, Okhotsk Evenki, Ulchi, and Negidal) were determined for the three most polymorphic HLA class II loci ( DRB1, DQA1, and DQB1) by a combination of single-stranded conformational polymorphism typing and DNA sequencing...
  46. Graham R, Ortmann W, Langefeld C, Jawaheer D, Selby S, Rodine P, et al. Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet. 2002;71:543-53 pubmed
    ..b>DRB1 and DQB1 typing of founders showed that the three haplotypes contained DRB1*1501/ DQB1*0602, DRB1*0801/ DQB1*0402, ..
  47. O Hanlon T, Carrick D, Arnett F, Reveille J, Carrington M, Gao X, et al. Immunogenetic risk and protective factors for the idiopathic inflammatory myopathies: distinct HLA-A, -B, -Cw, -DRB1 and -DQA1 allelic profiles and motifs define clinicopathologic groups in caucasians. Medicine (Baltimore). 2005;84:338-49 pubmed
    ..We have performed low to high resolution genotyping to characterize the allelic profiles of HLA-A, -B, -Cw, -DRB1, and -DQA1 loci in a large population of North American Caucasian patients with IIM representing the major ..
  48. Matsuoka T, Matsushita T, Osoegawa M, Kawano Y, Minohara M, Mihara F, et al. Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis. Mult Scler. 2008;14:1181-90 pubmed publisher
    ..We aimed to disclose possible factors contributing to the development of such MRI features. Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser ..
  49. Matevosyan L, Chattopadhyay S, Madelian V, Avagyan S, Nazaretyan M, Hyussian A, et al. HLA-A, HLA-B, and HLA-DRB1 allele distribution in a large Armenian population sample. Tissue Antigens. 2011;78:21-30 pubmed publisher
    Human leukocyte antigen (HLA)-A, HLA-B, and HLA-DRB1 gene frequencies were investigated in 4279 unrelated Armenian bone marrow donors...
  50. Kochi Y, Yamada R, Kobayashi K, Takahashi A, Suzuki A, Sekine A, et al. Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences. Arthritis Rheum. 2004;50:63-71 pubmed
    To examine the entire HLA region for loci (other than the DRB1 locus) associated with rheumatoid arthritis (RA) susceptibility, by typing HLA-DRB1 alleles and multiple single-nucleotide polymorphisms (SNPs) in the Japanese population...
  51. Ovsyannikova I, Jacobson R, Vierkant R, O Byrne M, Poland G. Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations. Vaccine. 2009;27:6926-31 pubmed publisher
    ..2 IU/ml, p=0.002) alleles were associated with higher antibody levels in both populations. The association of DRB1*04-DQB1*03-DPB1*03 (mean 1st cohort 25.2 IU/ml, p=0.011; 2nd cohort 21.4 IU/ml, p=0...
  52. Ballerini C, Guerini F, Rombolà G, Rosati E, Massacesi L, Ferrante P, et al. HLA-multiple sclerosis association in continental Italy and correlation with disease prevalence in Europe. J Neuroimmunol. 2004;150:178-85 pubmed
    The association with HLA-DRB1 alleles was tested in 609 Continental Italian MS patients and 836 controls. The phenotype frequency of DRB1*15 in the patients was significantly higher (0.316 vs. 0.112; p(c)<10(-6); Odds Ratio (OR)=3...
  53. Nakanishi K, Inoko H. Combination of HLA-A24, -DQA1*03, and -DR9 contributes to acute-onset and early complete beta-cell destruction in type 1 diabetes: longitudinal study of residual beta-cell function. Diabetes. 2006;55:1862-8 pubmed
  54. Wu J, Qiu W, Castley A, James I, Mastaglia F, Christiansen F, et al. Modifying effects of HLA-DRB1 allele interactions on age at onset of multiple sclerosis in Western Australia. Mult Scler. 2010;16:15-20 pubmed publisher
    ..Our objective was to investigate the disease modifying effects of HLA-DRB1 alleles and allele interactions on age at onset of multiple sclerosis...
  55. Parks C, Pandey J, Dooley M, Treadwell E, St Clair E, Gilkeson G, et al. Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic lupus erythematosus: associations and interaction with the interleukin-1alpha-889 C/T polymorphism. Hum Immunol. 2004;65:622-31 pubmed
    ..0, p < 0.00001) for the combined "HLA-DR3, TNF-alpha -308A, IL-1alpha -889C/C" genotype. These findings provide evidence of cytokine gene epistasis in SLE susceptibility. ..
  56. LaFleur C, Granados J, Vargas Alarcon G, Ruíz Morales J, Villarreal Garza C, Higuera L, et al. HLA-DR antigen frequencies in Mexican patients with dengue virus infection: HLA-DR4 as a possible genetic resistance factor for dengue hemorrhagic fever. Hum Immunol. 2002;63:1039-44 pubmed
    The human leukocyte antigen DRB1 locus (HLA-DRB1) was typed in genomic DNA extracted from whole blood samples of 34 Mexican dengue hemorrhagic fever (DHF) patients and 47 dengue fever (DF) patients, by polymerase chain reaction-sequence-..
  57. Kummee P, Tangkijvanich P, Poovorawan Y, Hirankarn N. Association of HLA-DRB1*13 and TNF-alpha gene polymorphisms with clearance of chronic hepatitis B infection and risk of hepatocellular carcinoma in Thai population. J Viral Hepat. 2007;14:841-8 pubmed
    ..Additional study is needed to validate these finding and to further explore the genetic pathogenesis of HBV infection. ..
  58. Lundström E, Kallberg H, Smolnikova M, Ding B, Ronnelid J, Alfredsson L, et al. Opposing effects of HLA-DRB1*13 alleles on the risk of developing anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis. Arthritis Rheum. 2009;60:924-30 pubmed publisher
    The effect of non-shared epitope HLA-DRB1 alleles on rheumatoid arthritis (RA) is poorly understood...
  59. Engelmann R, Eggert M, Neeck G, Mueller Hilke B. The impact of HLA-DRB alleles on the subclass titres of antibodies against citrullinated peptides. Rheumatology (Oxford). 2010;49:1862-6 pubmed publisher
    ..antibodies directed against citrullinated peptide antigens (ACPAs) and investigated the association between HLA-DRB1 shared epitope (SE) alleles and the IgG subclass titres of cyclic citrullinated peptide (CCP)- and mutated ..
  60. Hussain A, Wesley C, Khalid M, Chaudhry A, Jameel S. Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation. J Virol. 2008;82:893-902 pubmed
    ..Thus, the Vpu protein also contributes to viral persistence by attenuating immune responses during HIV infection. This report further exemplifies the rich diversity and redundancy shown by HIV in immune evasion. ..
  61. Luongo V, Pirozzi G, Caraco C, Errico S, de Angelis F, Celentano E, et al. HLA allele frequency and clinical outcome in Italian patients with cutaneous melanoma. Tissue Antigens. 2004;64:84-7 pubmed
    ..A*01 seems to be correlated with a less aggressive variant of the disease, whereas DRB1*01-DQB1*0501 seems to be associated with metastatic progression of melanoma...
  62. Arnaiz Villena A, Martinez Laso J, Moscoso J, Livshits G, Zamora J, Gomez Casado E, et al. HLA genes in the Chuvashian population from European Russia: admixture of Central European and Mediterranean populations. Hum Biol. 2003;75:375-92 pubmed
    ..Thus, present-day Chuvash who speak an Altaic-Turkic language are probably more closely related to ancient Mesopotamian-Hittites and northern European populations than to central Asia-Altaic people. ..
  63. Charpin C, Balandraud N, Guis S, Roudier C, Toussirot E, Rak J, et al. HLA-DRB1*0404 is strongly associated with high titers of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis. Clin Exp Rheumatol. 2008;26:627-31 pubmed
    To test whether the presence of RA associated HLA-DRB1*0101, HLA-DRB1*0401 and HLA-DRB1*0404 alleles individually influences anti-cyclic citrullinated peptide antibodies (anti-CCP) production...
  64. Laine A, Hermann R, Knip M, Simell O, Akerblom H, Ilonen J. The human leukocyte antigen genotype has a modest effect on the insulin gene polymorphism-associated susceptibility to type 1 diabetes in the Finnish population. Tissue Antigens. 2004;63:72-4 pubmed
  65. Lin Z, Xin Y, Dong Q, Wang Q, Jiang X, Zhan S, et al. Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma: a meta-analysis. BMC Gastroenterol. 2010;10:145 pubmed publisher
    HLA-DRB1 allele polymorphisms have been reported to be associated with hepatocellular carcinoma susceptibility, but the results of these previous studies have been inconsistent...
  66. Lampis R, Morelli L, Congia M, Macis M, Mulargia A, Loddo M, et al. The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases. Hum Mol Genet. 2000;9:2959-65 pubmed
    ..We first examined the distribution of the HLA-DRB1-DQA1-DQB1 haplotypes in 631 newborns from seven different regions of the island, and found that the most frequent ..
  67. Low A, Azmy I, Sharaf N, Cannings C, Wilson A. Association between two tumour necrosis factor intronic polymorphisms and HLA alleles. Eur J Immunogenet. 2002;29:31-4 pubmed
    ..08 (+489A) and 0.05 (+691Gdel). The +489A allele is associated with carriage of DRB1*1104, DQB1*0301, B18 and B35. The +691Gdel allele is associated with carriage of DRB1*13 *11, DQB1*0301 and B44...
  68. Mattey D, Dawes P, Fisher J, Brownfield A, Thomson W, Hajeer A, et al. Nodular disease in rheumatoid arthritis: association with cigarette smoking and HLA-DRB1/TNF gene interaction. J Rheumatol. 2002;29:2313-8 pubmed
    To investigate the association of nodular disease in rheumatoid arthritis (RA) with smoking, seropositivity, and polymorphisms at HLA-DRB1 and TNF loci.
  69. Zhou S, Lin L, Jin P, Ye S. [Association between HLA-DRB1, DQB1 genes and pemphigus vulgaris in Chinese Hans]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003;20:79-81 pubmed
    To investigate the predisposing role of HLA-DRB1, DQB1 genes in pemphigus vulgaris (PV)...
  70. Fourlanos S, Varney M, Tait B, Morahan G, Honeyman M, Colman P, et al. The rising incidence of type 1 diabetes is accounted for by cases with lower-risk human leukocyte antigen genotypes. Diabetes Care. 2008;31:1546-9 pubmed publisher
    ..To examine these possibilities, human leukocyte antigen (HLA) class II DRB1 genes known to confer risk for type 1 diabetes were analyzed in relation to year of birth and age at diagnosis over ..
  71. Levinson R, See R, Rajalingam R, Reed E, Park M, Rao N, et al. HLA-DRB1 and -DQB1 alleles in mestizo patients with Vogt-Koyanagi-Harada's disease in Southern California. Hum Immunol. 2004;65:1477-82 pubmed
    We evaluated human leukocyte antigen (HLA)-DRB1 and -DQB1 alleles as genetic markers for Vogt-Koyanagi-Harada (VKH) disease in Mestizo patients in Southern California...
  72. Dorak M, Yee L, Tang J, Shao W, Lobashevsky E, Jacobson L, et al. HLA-B, -DRB1/3/4/5, and -DQB1 gene polymorphisms in human immunodeficiency virus-related Kaposi's sarcoma. J Med Virol. 2005;76:302-10 pubmed
    ..HLA-B, DRB1, DRB3, DRB4, DRB5, and DQB1 polymorphisms were examined by high-resolution DNA-based methods...
  73. Alkharsah K, Dedicoat M, Blasczyk R, Newton R, Schulz T. Influence of HLA alleles on shedding of Kaposi sarcoma-associated herpesvirus in saliva in an African population. J Infect Dis. 2007;195:809-16 pubmed
    ..of KSHV in the saliva of mothers in rural South Africa, we sequenced the HLA-A alleles of 448 mothers and the HLA-DRB1 alleles of 363 mothers and compared their HLA types with viral loads in saliva...
  74. Yoon J, Shin S, Park M, Song E, Roh E. HLA-A, -B, -DRB1 allele frequencies and haplotypic association from DNA typing data of 7096 Korean cord blood units. Tissue Antigens. 2010;75:170-3 pubmed publisher
    ..A total of 14 HLA-A, 33 HLA-B, 13 HLA-DRB1 alleles and 2470 three-locus haplotypes were identified...
  75. Motzo C, Contu D, Cordell H, Lampis R, Congia M, Marrosu M, et al. Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes. Diabetes. 2004;53:3286-91 pubmed
    ..concerning the joint action of the two established type 1 diabetes susceptibility loci, the HLA class II DQB1 and DRB1 genes (IDDM1) and the insulin gene (INS) promoter (IDDM2)...
  76. Cordovado S, Zhao Y, Warram J, Gong H, Anderson K, Hendrix M, et al. Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study. Diabetes. 2008;57:518-22 pubmed
    The purpose of this study was to examine whether known genetic risk factors for type 1 diabetes (HLA-DRB1, -DQA1, and -DQB1 and insulin locus) play a role in the etiology of diabetic nephropathy...
  77. Kuniholm M, Kovacs A, Gao X, Xue X, Marti D, Thio C, et al. Specific human leukocyte antigen class I and II alleles associated with hepatitis C virus viremia. Hepatology. 2010;51:1514-22 pubmed publisher
    ..b>DRB1*0101 (prevalence ratio [PR] = 1.7; 95% confidence interval [CI] = 1.1-2.6), B*5701 (PR=2.0; 95% CI = 1.0-3...
  78. Brynedal B, Duvefelt K, Jonasdottir G, Roos I, Akesson E, Palmgren J, et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS ONE. 2007;2:e664 pubmed
    ..mapped the entire genetic effect to the HLA-DR-DQ subregion, reflected by the well-established risk haplotype HLA-DRB1*15,DQB1*06...
  79. Mewar D, Marinou I, Coote A, Moore D, Akil M, Smillie D, et al. Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection. Ann Rheum Dis. 2008;67:980-3 pubmed
    To investigate the association of a recently described classification of Human leukocyte antigen (HLA)-DRB1 shared epitope alleles with rheumatoid factors (RF) and anti-cyclic citrullinated peptide (CCP) production and radiological ..
  80. Yano T, Yamada K, Kimura A, Takeshita T, Minohara M, Kira J, et al. Autoimmunity against neurofilament protein and its possible association with HLA-DRB1*1502 allele in glaucoma. Immunol Lett. 2005;100:164-9 pubmed
    ..05). In addition, our immunogenetic analysis showed a possible association between HLA-DRB1*1502 allele and the patients positive for anti-NF-L autoantibodies...
  81. McKiernan S, Hagan R, Curry M, McDonald G, Kelly A, Nolan N, et al. Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology. 2004;40:108-14 pubmed
    ..with previously reported class II allele associations, over 75% that successfully eliminate HCV carry either A*03, DRB1*0101, or *0401, compared with only 37% of those with chronic infection (P <.0001)...
  82. Ding B, Padyukov L, Lundström E, Seielstad M, Plenge R, Oksenberg J, et al. Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region. Arthritis Rheum. 2009;60:30-8 pubmed publisher
    ..In a multistep analytical strategy using unmatched as well as matched analyses to adjust for HLA-DRB1 genotype, we analyzed 2,221 single-nucleotide polymorphisms (SNPs) spanning 10.7 Mb, from 6p22.2 to 6p21...
  83. Price P, Cheong K, Boodhoo A, Witt C, McCann V, Christiansen F, et al. Can MHC class II genes mediate resistance to type 1 diabetes?. Immunol Cell Biol. 2001;79:602-6 pubmed
    Numerous studies have associated carriage of HLA-DRB1*1501, DQA1*0102 and DQB1*0602 (DR15, DQ6) with dominant resistance to type 1 diabetes and have concluded that one or more of the component HLA class II molecules mediate this effect...
  84. Czaja A, Carpenter H, Moore S. HLA DRB1*13 as a risk factor for type 1 autoimmune hepatitis in North American patients. Dig Dis Sci. 2008;53:522-8 pubmed
    Our goal was to determine if HLA DRB1*13 is associated with autoimmune hepatitis in North American patients...
  85. Hughes L, Morrison D, Kelley J, Padilla M, Vaughan L, Westfall A, et al. The HLA-DRB1 shared epitope is associated with susceptibility to rheumatoid arthritis in African Americans through European genetic admixture. Arthritis Rheum. 2008;58:349-58 pubmed publisher
    To determine whether shared epitope (SE)-containing HLA-DRB1 alleles are associated with rheumatoid arthritis (RA) in African Americans and whether their presence is associated with higher degrees of global (genome-wide) genetic admixture ..
  86. Gambelunghe G, Gerli R, Bocci E, Del Sindaco P, Ghaderi M, Sanjeevi C, et al. Contribution of MHC class I chain-related A (MICA) gene polymorphism to genetic susceptibility for systemic lupus erythematosus. Rheumatology (Oxford). 2005;44:287-92 pubmed
    ..HLA-DRB1-DQA1-DQB1 genotyping, MICA exon 5 microsatellite genotyping and HLA-B8 genotyping were performed in 48 Italian SLE ..
  87. Rojas Villarraga A, Ortega Hernandez O, Gomez L, Pardo A, Lopez Guzman S, Arango Ferreira C, et al. Risk factors associated with different stages of atherosclerosis in Colombian patients with rheumatoid arthritis. Semin Arthritis Rheum. 2008;38:71-82 pubmed publisher
    ..0). A duration of RA >10 years (AOR = 29.0) and being a carrier of an HLA-DRB1 shared epitope allele (AOR = 4.8) were associated with atherosclerotic plaque...
  88. Lincoln M, Ramagopalan S, Chao M, Herrera B, DeLuca G, Orton S, et al. Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A. 2009;106:7542-7 pubmed publisher
    ..Susceptibility is associated with the MHC class II region, especially HLA-DRB5*0101-HLA-DRB1*1501-HLA-DQA1*0102-HLA-DQB1*0602 haplotypes(hereafter DR2), which dominate genetic contribution to MS risk...