HLA-DQB2

Summary

Gene Symbol: HLA-DQB2
Description: major histocompatibility complex, class II, DQ beta 2
Alias: HLA-DQB1, HLA-DXB, DV19.1 (major histocompatibility complex, class II, DQ beta 2 (HLA-DXB)), HLA class II histocompatibility antigen, DQ beta 2 chain, HLA class II histocompatibility antigen, DX beta chain, MHC class II antigen DQB2, major histocompatibility complex, class II, DQ beta 1
Species: human

Top Publications

  1. doi HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway
    Ashutosh Chaudhry
    National Institute of Immunology, New Delhi, India
    J Immunol 183:2415-24. 2009
  2. doi Role of HIV-1 Nef protein for virus replication in vitro
    Abhay Jere
    Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Microbes Infect 12:65-70. 2010
  3. ncbi Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help
    N Chirmule
    Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030
    Cell Immunol 155:169-82. 1994
  4. ncbi HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes
    K M Callahan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 151:2928-42. 1993
  5. ncbi Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC
    J F Rowell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 155:473-88. 1995
  6. ncbi Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA
    H Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    Biochem Biophys Res Commun 279:494-9. 2000
  7. ncbi Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
    L K Clayton
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts
    Nature 339:548-51. 1989
  8. pmc HIV-1 Nef impairs MHC class II antigen presentation and surface expression
    P Stumptner-Cuvelette
    Institut National de la Santé et de la Recherche Médicale U520 and Centre National de la Recherche Scientifique UMR144, Institut Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 98:12144-9. 2001
  9. ncbi HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells
    Marc A Williams
    Division of Pediatric Infectious Diseases, University of California at San Diego, The School of Medicine, La Jolla 92093, USA
    J Hematother Stem Cell Res 11:829-47. 2002
  10. pmc Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation
    Amjad Hussain
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Virol 82:893-902. 2008

Research Grants

  1. Role of specific Nef functions in AIDS pathogenesis
    Frank Kirchhoff; Fiscal Year: 2007

Scientific Experts

  • Frank Kirchhoff
  • Myint Oo Chang
  • Yoshihiro Onouchi
  • Marc A Williams
  • Sharon A Chung
  • Ashutosh Chaudhry
  • Joseph Vijai
  • Cédric Lenormand
  • Leonia Bozzacco
  • Young Ho Lee
  • Hamdi Mbarek
  • Xinhui Ge
  • Yanina Ghiglione
  • Abhay Jere
  • Y J Lin
  • Shahid Jameel
  • Amjad Hussain
  • Atsushi Takahashi
  • Tatsuhiko Tsunoda
  • Yusuke Nakamura
  • Yuta Kochi
  • Michael Schindler
  • Rohini Rau-Murthy
  • Kasmintan A Schrader
  • Mark Robson
  • Dina Ben-Yehuda
  • Kara Sarrel
  • Sohela Shah
  • Jennifer Brown
  • David Straus
  • Carol Portlock
  • Steven M Lipkin
  • Agnes Viale
  • Kenneth Offit
  • Tomas Kirchhoff
  • Liying Zhang
  • Andrew Zelenetz
  • Mortimer Lacher
  • Christopher Manschreck
  • Ana Virginia Dutra-Clarke
  • Nichole Hansen
  • Zsofia Stadler
  • Robert J Klein
  • Srujana Cheguri
  • Jennifer Przybylo
  • Ora Paltiel
  • Ralph M Steinman
  • Sung Jae Choi
  • Jörn Dengjel
  • Nawei Zhang
  • Victoria Kuttner
  • Haiteng Deng
  • Henri de la Salle
  • Maryse Peressin
  • Daniel Hanau
  • Beatrix M Ueberheide
  • Gwan Gyu Song
  • P Stumptner-Cuvelette
  • Henry A Zebroski
  • Svetlana Mojsov
  • Florence Gross
  • P Indovina
  • Haiqiang Yu
  • Dominique Fricker
  • David Fenyo
  • François Signorino-Gelo
  • Christine Trumpfheller
  • Sang Cheol Bae
  • Jean Pierre Cazenave
  • Thomas Bieber
  • Huguette Bausinger
  • Susanne Koch
  • Sylvie Tourne
  • Jong Dae Ji
  • Brian T Chait
  • Eddie A James
  • Naoyuki Kamatani
  • Michiaki Kubo
  • Hidenori Ochi
  • Vinod Kumar
  • Naoya Hosono
  • Yuji Urabe
  • Helena Reijonen
  • Kazuaki Chayama
  • Yoichiro Kamatani
  • Gabriela Turk
  • Hiromi Abe
  • William W Kwok
  • Koichi Matsuda
  • Daiki Miki

Detail Information

Publications41

  1. doi HIV-1 Nef promotes endocytosis of cell surface MHC class II molecules via a constitutive pathway
    Ashutosh Chaudhry
    National Institute of Immunology, New Delhi, India
    J Immunol 183:2415-24. 2009
    ..Thus, Nef-mediated endocytosis of MHCII provides a novel perspective on the regulation of normal MHCII trafficking...
  2. doi Role of HIV-1 Nef protein for virus replication in vitro
    Abhay Jere
    Department of Microbiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Microbes Infect 12:65-70. 2010
    ..This review summarizes and organizes current knowledge of HIV-1 Nef with respect to this particularly virological activity for understanding the basis of its in vivo function...
  3. ncbi Envelope glycoproteins of HIV-1 interfere with T-cell-dependent B cell differentiation: role of CD4-MHC class II interaction in the effector phase of T cell help
    N Chirmule
    Department of Pediatrics, North Shore University Hospital, Cornell University Medical College, Manhasset, New York 11030
    Cell Immunol 155:169-82. 1994
    ..Furthermore, these latter reactions occur subsequent to T-B cell contact-dependent interactions at the effector phase, which involve MHC class II molecules on B cells and CD4 molecules on T cells...
  4. ncbi HIV-1 envelope protein is expressed on the surface of infected cells before its processing and presentation to class II-restricted T lymphocytes
    K M Callahan
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205
    J Immunol 151:2928-42. 1993
    ..These results provide the first direct evidence that endogenously synthesized membrane proteins enter the class II-restricted Ag-processing pathway after expression on the cell surface in an intact form...
  5. ncbi Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC
    J F Rowell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 155:473-88. 1995
    ....
  6. ncbi Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA
    H Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    Biochem Biophys Res Commun 279:494-9. 2000
    ..These reciprocal actions between Tat and CIITA not only explains the functional impairment of APC in HIV-1 infection but also rationalizes the suppression of HIV-1 virus load by induction of CIITA such as IFN-gamma...
  7. ncbi Identification of human CD4 residues affecting class II MHC versus HIV-1 gp120 binding
    L K Clayton
    Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts
    Nature 339:548-51. 1989
    ....
  8. pmc HIV-1 Nef impairs MHC class II antigen presentation and surface expression
    P Stumptner-Cuvelette
    Institut National de la Santé et de la Recherche Médicale U520 and Centre National de la Recherche Scientifique UMR144, Institut Curie, 75005 Paris, France
    Proc Natl Acad Sci U S A 98:12144-9. 2001
    ..Cooperation between those mechanisms may enable Nef to efficiently inhibit MHC II function...
  9. ncbi HIV-1 gp120 modulates the immunological function and expression of accessory and co-stimulatory molecules of monocyte-derived dendritic cells
    Marc A Williams
    Division of Pediatric Infectious Diseases, University of California at San Diego, The School of Medicine, La Jolla 92093, USA
    J Hematother Stem Cell Res 11:829-47. 2002
    ..Consequently, HIV-1 gp120 may actively contribute to the immunopathogenesis of AIDS...
  10. pmc Human immunodeficiency virus type 1 Vpu protein interacts with CD74 and modulates major histocompatibility complex class II presentation
    Amjad Hussain
    Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    J Virol 82:893-902. 2008
    ..Thus, the Vpu protein also contributes to viral persistence by attenuating immune responses during HIV infection. This report further exemplifies the rich diversity and redundancy shown by HIV in immune evasion...
  11. pmc Strategy for identifying dendritic cell-processed CD4+ T cell epitopes from the HIV gag p24 protein
    Leonia Bozzacco
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center, The Rockefeller University, New York, New York, United States of America
    PLoS ONE 7:e41897. 2012
    ..These results support the application of our strategy to identify and characterize peptide epitopes derived from vaccine proteins processed by DCs and thus has the potential to greatly accelerate DC-based vaccine development...
  12. pmc Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors
    Frank Kirchhoff
    Department of Virology, Universitatsklinikum, 89081 Ulm, Germany
    J Virol 78:6864-74. 2004
    ....
  13. pmc Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles
    Michael Schindler
    Department of Virology, Universitatsklinikum, 89081 Ulm, Germany
    J Virol 77:10548-56. 2003
    ..Overall, our results suggest that the ability of Nef to interfere with MHC-II antigen presentation might play a role in AIDS pathogenesis...
  14. pmc Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies
    Joseph Vijai
    Clinical Genetics Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    PLoS Genet 9:e1003220. 2013
    ..These results, showing novel susceptibility regions and allelic heterogeneity, point to the existence of pathways of susceptibility to both shared as well as specific subtypes of lymphoid malignancy...
  15. doi A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population
    Hamdi Mbarek
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato, Tokyo
    Hum Mol Genet 20:3884-92. 2011
    ..03 and 5.02, respectively) as risk haplotypes. These findings indicated that variants in antigen-binding regions of HLA-DP and HLA-DQ contribute to the risk of persistent HBV infection...
  16. doi HIV-1 Gag-virus-like particles induce natural killer cell immune responses via activation and maturation of dendritic cells
    Myint Oo Chang
    High Technology Research Centre, Chiba Institute of Technology, Narashino, Japan
    J Innate Immun 4:187-200. 2012
    ..Our findings reveal that Gag-VLPs efficiently activate DCs, which in turn induce innate and Gag-specific immune responses in NK cells...
  17. doi HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule
    Cédric Lenormand
    INSERM, Unité Mixte de Recherche S725, Biologie des Cellules Dendritiques Humaines, Strasbourg, 67065 France
    J Immunol 188:3903-11. 2012
    ..The HLA-DQα2/β2 molecules could influence the complexity of the repertoire of Ags presented by LCs...
  18. doi A genome-wide association study identifies three new risk loci for Kawasaki disease
    Yoshihiro Onouchi
    Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan
    Nat Genet 44:517-21. 2012
    ..6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease...
  19. doi Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis
    Young Ho Lee
    Division of Rheumatology, Department of Internal Medicine, Korea University Anam Hospital, Korea University College of Medicine, 126 1, 5 ga, Anam Dong, Seongbuk gu, Seoul, 136 705, Korea
    Mol Biol Rep 39:10627-35. 2012
    ....
  20. ncbi Nef performance in macrophages: the master orchestrator of viral persistence and spread
    Yanina Ghiglione
    National Reference Center for AIDS, University of Buenos Aires, Paraguay, Buenos Aires, Argentina
    Curr HIV Res 9:505-13. 2011
    ..Here, we will review the newest findings describing how monocytes/macrophages natural pathways are altered by Nef protein, highlighting how viral and host biology are perturbed in consequence...
  21. ncbi Nucleotide sequencing of HLA-DQ gene second exons in Chinese homozygous cells
    Y Wang
    Molecular Genetics Laboratory, United Kingdom Transplant Support Service, Bristol
    Eur J Immunogenet 19:287-93. 1992
    ....
  22. pmc Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production
    Sharon A Chung
    Rosalind Russell Medical Research Center for Arthritis, Department of Medicine, University of California San Francisco, United States of America
    PLoS Genet 7:e1001323. 2011
    ..Lack of strong SNP associations may suggest that other types of genetic variation or non-genetic factors such as environmental exposures have a greater impact on susceptibility to anti-dsDNA - SLE...
  23. ncbi AIDS and related syndromes as a viral-induced autoimmune disease of the immune system: an anti-MHC II disorder. Therapeutic implications
    J M Andrieu
    AIDS Res 2:163-74. 1986
  24. ncbi Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes
    A K Jonsson
    J Biol Chem 262:8767-77. 1987
    ..Comparison of the number of nucleotide substitutions in the DQ beta first and second domain exons suggests that little or no phenotypic selection acts on the first domain whereas the second domain is under strong selection...
  25. ncbi Remarkable sequence conservation of the HLA-DQB2 locus (DX beta) within the highly polymorphic DQ subregion of the human MHC
    J Berdoz
    Department of Microbiology, University of Geneva Medical School, Switzerland
    Immunogenetics 29:241-8. 1989
    ..The latter would imply that the HLA-DQ2 genes are expressed into a protein product endowed with essential functional properties...
  26. ncbi Inhibition of CD4+ T cell function by the HIV envelope protein, gp120
    D C Diamond
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 141:3715-7. 1988
    ..Using a murine T cell hybridoma which expresses the human CD4 protein and exhibits a CD4-dependent response to Ag, we demonstrate that the HIV envelope protein gp120 can specifically inhibit this response...
  27. pmc Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules
    M R Bowman
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA 02115
    Proc Natl Acad Sci U S A 87:9052-6. 1990
    ..These observations are consistent with a three-dimensional model of the V1 domain of CD4 that was developed in order to understand the structural basis for binding to CD4...
  28. ncbi HIV-gp120 can block CD4-class II MHC-mediated adhesion
    Y Rosenstein
    Division of Pediatric Oncology, Dana Farber Cancer Institute, Boston, MA
    J Immunol 144:526-31. 1990
    ..These data indicate that T lymphocyte adhesion mediated by CD4 is a dynamic event and that binding of gp120 to CD4 is able to disrupt the normal progression of the interaction between CD4+ T lymphocytes and class II+ APC...
  29. ncbi Interaction of CD4 with HLA class II antigens and HIV gp120
    D Piatier-Tonneau
    Institut d Embryologie Cellulaire et Moleculaire, CNRS, College de France, Nogent sur Marne
    Immunogenetics 34:121-8. 1991
    ....
  30. pmc Differences in self-peptide binding between T1D-related susceptible and protective DR4 subtypes
    Xinhui Ge
    Benaroya Research Institute at Virginia Mason, Seattle, WA 98101, USA
    J Autoimmun 36:155-60. 2011
    ..The enhanced peptide competition of DR0403 leads to a down-modulation of DQ8 epitope presentation, as compared to weak competitors such as DR0401 and DR0405, and therefore contributes to disease protection...
  31. ncbi HLA class II antigens and the HIV envelope glycoprotein gp120 bind to the same face of CD4
    R Houlgatte
    Unité de Génétique Moléculaire et de Biologie du Développement UPR 420, Centre National de la Recherche Scientifique, Villejuif, France
    J Immunol 152:4475-88. 1994
    ..Thus, CD4 appears to interact with HLA class II molecules mainly through the HIV gp120 binding site and possibly through a second minor interaction site mapping on the same face of the molecule...
  32. ncbi Absence of in vivo DNA-protein interactions in the DQA2 and DQB2 promoter regions
    P Indovina
    Dipartimento di Medicina Sperimentale e Patologia, Universita La Sapienza, Rome, Italy
    Hum Immunol 62:504-8. 2001
    ..These findings suggest that the very low level of DQA2 expression and the apparent lack of DQB2 activity are caused by the reduced binding affinity of specific transcription factors...
  33. ncbi Tat competes with CIITA for the binding to P-TEFb and blocks the expression of MHC class II genes in HIV infection
    S Kanazawa
    Howard Hughes Medical Institute, Department of Medicine, University of California, San Francisco 94143, USA
    Immunity 12:61-70. 2000
    ..Moreover, a dominant-negative CDK9 protein inhibits the activity of MHC II promoters. Thus, CIITA is a novel cellular coactivator that binds to P-TEFb for the expression of its target genes...
  34. ncbi The enhanced immune response to the HIV gp160/LAMP chimeric gene product targeted to the lysosome membrane protein trafficking pathway
    A L Ruff
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Biol Chem 272:8671-8. 1997
    ....
  35. ncbi Evolutionary dynamics of non-coding sequences within the class II region of the human MHC
    S Beck
    DNA Sequencing Laboratory, Imperial Cancer Research Fund, London, England
    J Mol Biol 255:1-13. 1996
    ..We also report the finding of a class I-related pseudogene (HLA-ZI) in the middle of the class II region, which provides the first direct evidence for DNA exchange between these two related regions in man...
  36. ncbi Analysis of single-nucleotide polymorphisms in Japanese rheumatoid arthritis patients shows additional susceptibility markers besides the classic shared epitope susceptibility sequences
    Yuta Kochi
    University of Tokyo, Tokyo, Japan
    Arthritis Rheum 50:63-71. 2004
    ..To examine the entire HLA region for loci (other than the DRB1 locus) associated with rheumatoid arthritis (RA) susceptibility, by typing HLA-DRB1 alleles and multiple single-nucleotide polymorphisms (SNPs) in the Japanese population...
  37. ncbi HIV-1 gp41 binding proteins and antibodies to gp41 could inhibit enhancement of human Raji cell MHC class I and II expression by gp41
    Y H Chen
    Ludwig Boltzmann Institute of AIDS Research, Innsbruck, Austria
    Mol Immunol 31:977-82. 1994
    ....
  38. ncbi HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71)
    N Chirmule
    Department of Pediatrics, North Shore University Hospital Cornell University Medical College, Manhasset, NY 11030, USA
    J Immunol 155:917-24. 1995
    ....
  39. doi HLA-E gene polymorphism associated with susceptibility to Kawasaki disease and formation of coronary artery aneurysms
    Y J Lin
    China Medical University Hospital, China Medical University, and Asia University, Taichung, Taiwan
    Arthritis Rheum 60:604-10. 2009
    ..The purpose of this study was to identify possible genetic variants in the major histocompatibility complex (MHC) region that are associated with KD and the development of coronary artery aneurysms (CAAs) in a Taiwanese population...
  40. pmc Efficient incorporation of HLA class II onto human immunodeficiency virus type 1 requires envelope glycoprotein packaging
    D T Poon
    AIDS Vaccine Program, SAIC Frederick, National Cancer Institute, Frederick Cancer Research and Development Center, Frederick, Maryland 21702 1201, USA
    J Virol 74:3918-23. 2000
    ..These data show that HIV-1 actively incorporates HLA class II proteins in a process that, either directly or indirectly, requires Env...

Research Grants3

  1. Role of specific Nef functions in AIDS pathogenesis
    Frank Kirchhoff; Fiscal Year: 2007
    ....