HLA-DQB1

Summary

Gene Symbol: HLA-DQB1
Description: major histocompatibility complex, class II, DQ beta 1
Alias: CELIAC1, HLA-DQB, IDDM1, HLA class II histocompatibility antigen, DQ beta 1 chain, MHC DQ beta, MHC class II DQ beta chain, MHC class II HLA-DQ beta glycoprotein, MHC class II antigen DQB1, MHC class II antigen HLA-DQ-beta-1, MHC class2 antigen, lymphocyte antigen
Species: human

Top Publications

  1. pmc Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
  2. pmc GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma
    Karin E Smedby
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 7:e1001378. 2011
  3. doi HLA-Class II in Latin American patients with type 1 diabetes
    Adriana Rojas-Villarraga
    Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 9:666-73. 2010
  4. doi IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 70:706-10. 2009
  5. doi Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes
    Hakbany Manan
    Department of Physiology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Hum Immunol 71:1238-42. 2010
  6. pmc Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 58:1028-33. 2009
  7. ncbi Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    Susan M McKiernan
    Hepatology Center, St James s Hospital and Trinity College, Dublin, Ireland
    Hepatology 40:108-14. 2004
  8. ncbi The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Italy
    Tissue Antigens 56:515-21. 2000
  9. pmc Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts
    Priya Duggal
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 158:235-45. 2013
  10. ncbi Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP
    F C Gilchrist
    Interstitial Lung Disease Unit, Imperial College at the National Heart and Lung Institute, London, UK
    Genes Immun 2:76-81. 2001

Detail Information

Publications292 found, 100 shown here

  1. pmc Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
    ..We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9))...
  2. pmc GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma
    Karin E Smedby
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 7:e1001378. 2011
    ..These findings suggest that the HLA class II region plays a complex yet important role in NHL...
  3. doi HLA-Class II in Latin American patients with type 1 diabetes
    Adriana Rojas-Villarraga
    Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 9:666-73. 2010
    ..To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis...
  4. doi IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 70:706-10. 2009
    ..76, p = 0.19) and no interaction with HLA-DQ-linked risk. Furthermore, no genotype-phenotype correlation was observed. In conclusion, IFIH1 has no important role in T1D risk assessment in a registry-based Belgian population...
  5. doi Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes
    Hakbany Manan
    Department of Physiology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Hum Immunol 71:1238-42. 2010
    ..In conclusion, these results show a strong association of HLA-DQB1*0201/0302 and DRB1*03/04 with T1DM. Thus, combining genetic markers with autoantibody is useful in a screening program for early detection of T1DM among Saudi children...
  6. pmc Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 58:1028-33. 2009
    ..We examined whether some of these alleles influence development of islet autoimmunity or progression from persistent islet autoimmunity to type 1 diabetes in children with high-risk HLA-DR,DQ genotypes...
  7. ncbi Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    Susan M McKiernan
    Hepatology Center, St James s Hospital and Trinity College, Dublin, Ireland
    Hepatology 40:108-14. 2004
    ..More significantly, either HLA-A*03, -DRB1*0101, or -*0401 are carried by an overwhelming majority of those subjects who successfully clear HCV...
  8. ncbi The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Italy
    Tissue Antigens 56:515-21. 2000
    ....
  9. pmc Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts
    Priya Duggal
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Ann Intern Med 158:235-45. 2013
    ..Chinese translation..
  10. ncbi Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP
    F C Gilchrist
    Interstitial Lung Disease Unit, Imperial College at the National Heart and Lung Institute, London, UK
    Genes Immun 2:76-81. 2001
    ..0000003). We have identified a significant association between the ATA and HLA-DPB1*1301 which may provide an insight into how this autoantibody is formed. Patient clinical characteristics depend on the autoantibodies they carry...
  11. ncbi The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria
    S H Kim
    Department of Allergy and Rheumatology, Ajou University Hospital, Suwon 442 749, Korea
    Clin Exp Allergy 35:339-44. 2005
    ..Urticaria/angioedema is a common aspirin-induced allergy; however, its pathogenic mechanism is not understood...
  12. ncbi The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Ospedale Microcitemico, Via Jenner, Cagliari 09121, Italy
    Hum Mol Genet 9:2959-65. 2000
    ..These results indicate that robust case-control studies can be carried out in Sardinia offering cost efficiency over certain family-based designs...
  13. pmc Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes
    Kendra Vehik
    University of Colorado Denver, School of Medicine, Denver, Colorado, USA
    Diabetes Care 31:1392-6. 2008
    ....
  14. doi Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes
    Caroline Brorsson
    Hagedorn Research Institute and Steno Diabetes Center, Gentofte, Denmark
    Autoimmunity 44:107-14. 2011
    ....
  15. doi Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
    Sabina Resic-Lindehammer
    Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC Lund University, Ent 72 Bldg 91 Floor 10, 205 02 Malmo, Sweden
    Acta Diabetol 45:231-5. 2008
    ..0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk...
  16. ncbi Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype
    A Petrone
    Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy
    Diabetes Metab Res Rev 21:271-5. 2005
    ..We investigated whether residual insulin secretion and metabolic derangement at diagnosis of type 1 diabetes (T1DM) are influenced by human leukocyte antigens (HLA) class II genes...
  17. doi Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection
    Rae Anne Hardie
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS 22:807-16. 2008
    ..To determine the association of DQ antigens with resistance and susceptibility to HIV-1...
  18. ncbi Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes
    Jian Mei Yang
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311 1, Minamikawachi, Tochigi 329 0498, Japan
    Diabetes Res Clin Pract 71:164-9. 2006
    ..The IL-12B 3'UTR A-C polymorphism would be considered as a supplementary risk factor to T1DM in conjunction with HLA haplotypes...
  19. doi Genetic association of HLA DQB1 with CD4+CD25+(high) T-cell apoptosis in type 1 diabetes
    S Glisic
    Department of Pediatrics, Max McGee National Center for Juvenile Diabetes and Human Molecular Genetic Center, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    Genes Immun 10:334-40. 2009
    Type 1 diabetes (T1D) has a strong genetic component and the major locus lies in the HLA DQB1 region...
  20. ncbi Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC
    J F Rowell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 155:473-88. 1995
    ....
  21. doi HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy
    Hector Chinoy
    Centre for Integrated Genomic Medical Research, University of Manchester, UK
    Rheumatology (Oxford) 48:1213-7. 2009
    ..The HLA-DPB1 gene is centromeric to other HLA class II loci and separated by a recombination hotspot. We investigated whether HLA-DPB1 associations differ between anti-Jo-1 and anti-PM-Scl antibody-positive IIM cases...
  22. pmc Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Genet 42:426-9. 2010
    ..39 x 10(-9) in the combined analysis). Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors...
  23. pmc Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans
    Rebecca A Harris
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19014, USA
    Hepatology 48:70-9. 2008
    ..005; DQB1*03-DRB3*02: OR, 13.5, P = 0.001) but not among African American patients. Furthermore, although HLA DQB1*03, DRB1*11, and DRB3*02 genotypes were associated with increased HCV-specific CD4 T cell response in univariate ..
  24. pmc A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32
    Wendy Cozen
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
    Blood 119:469-75. 2012
    ..In a separate analysis, the DRB1*0701 allele was associated with a decreased risk of NSHL (OR = 0.5, 95% confidence interval = 0.4, 0.7). These data support the importance of the HLA class II region in NSHL etiology...
  25. ncbi Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE
    Robert R Graham
    Department of Molecular Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Eur J Hum Genet 15:823-30. 2007
    ..These data provide convincing evidence that particular combinations of HLA Class II DR2 and DR3 haplotypes are key determinants of autoantibody production and disease susceptibility in human SLE...
  26. ncbi Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica
    S S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 184:1310-4. 2001
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection...
  27. ncbi Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls
    Liene Nikitina-Zake
    Immunogenetics, Molecular Medicine, L8 00, Karolinska Hospital, Karolinska Institutet, 17176 Stockholm, Sweden
    Ann N Y Acad Sci 1037:161-9. 2004
    ..3), was higher. The maximum risk was when KIR2DL2, MICA5, and DR3/DR4 were in combination. In conclusion, our results suggest that a balance between innate and acquired immunity is important, and an imbalance coud lead to T1DM...
  28. pmc Diabetes-specific HLA-DR-restricted proinflammatory T-cell response to wheat polypeptides in tissue transglutaminase antibody-negative patients with type 1 diabetes
    Majid Mojibian
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada
    Diabetes 58:1789-96. 2009
    ..However, questions arise regarding the frequency of abnormal immune responses to wheat and their nature, and it remains unclear whether such responses are diabetes specific...
  29. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
    ..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
  30. doi Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies
    Ahmed J Delli
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Pediatr Diabetes 11:513-20. 2010
    ..We also determined whether they have different human leukocyte antigen (HLA) genetic markers and islet autoantibodies at diagnosis compared with Swedish patients...
  31. ncbi Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B
    S Nejentsev
    Juvenile Diabetes Foundation Center for Type 1 Diabetes Prevention in Finland, Turku
    Diabetes 49:2217-21. 2000
    ..Our data indicate that an additional gene associated with type 1 diabetes is located in the 240-kb region near HLA-B. We excluded STR MICA polymorphism as a mutation responsible for diabetes association...
  32. ncbi MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies
    M Malkki
    The Division of Clinical Research, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Tissue Antigens 66:114-24. 2005
    ..Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist...
  33. ncbi HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy
    M C Ellis
    Mercator Genetics, Inc, 4040 Campbell Ave, Menlo Park, CA 94025, USA
    Immunogenetics 46:410-7. 1997
    ..These results are consistent with other studies, suggesting that the HLA-DQ genes themselves are among the predisposing factors in narcolepsy...
  34. ncbi Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B
    Ye gui Jiang
    Institute of Infectious Diseases, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
    World J Gastroenterol 9:2221-5. 2003
    ..To investigate the association between the polymorphism of HLA-DRB1, -DQA1 and -DQB1 alleles and viral hepatitis B...
  35. doi Genome-wide association study of HPV seropositivity
    Dan Chen
    International Agency for Research on Cancer, Lyon, France
    Hum Mol Genet 20:4714-23. 2011
    ..This study provides a proof of principle that genetic variation plays a role in antibody reactivity to HPV infection...
  36. doi HLA class II alleles and chronic hepatitis C virus infection
    L O F Cangussu
    Viral Hepatitis Division, Instituto Alfa de Gastroenterologia, Hospital das Clínicas UFMG, Belo Horizonte, Minas Gerais, Brazil
    Scand J Immunol 74:282-7. 2011
    ....
  37. doi Polymorphisms of CXCR3-binding chemokines in type 1 diabetes
    Patrick Bruck
    Department of Internal Medicine IV, Division of Haematology and Oncology, University Hospital Giessen and Marburg, Germany
    Hum Immunol 70:552-5. 2009
    ..Although we did not find an association of the CXCL9 and CXCL10 polymorphisms with type 1 diabetes in the German population, we cannot discard their role in other populations or other autoimmune diseases...
  38. pmc The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies
    M Maziarz
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Genes Immun 11:406-15. 2010
    ..We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis...
  39. ncbi Concordance for type 1 diabetes in identical twins is affected by insulin genotype
    K A Metcalfe
    Department of Diabetes and Metabolic Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, UK
    Diabetes Care 24:838-42. 2001
    ..The aim of this study was to determine whether two susceptibility genes were less prevalent in discordant twins compared with concordant twins...
  40. pmc Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years
    Mette K Andersen
    Research Program for Molecular Medicine, Helsinki University, Helsinki, Finland
    Diabetes Care 33:2062-4. 2010
    ..We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years...
  41. ncbi HLA in Czech adult patients with autoimmune diabetes mellitus: comparison with Czech children with type 1 diabetes and patients with type 2 diabetes
    M Cerna
    Department of Cell and Molecular Biology, Third Medical Faculty of Charles University, Prague, Czech Republic
    Eur J Immunogenet 30:401-7. 2003
    ..Type 1 diabetes mellitus (DM) in children or adults may have partly different immunogenetic etiopathogenesis than LADA...
  42. ncbi Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs
    Fayza A Al-Jenaidi
    Al Jawhara Center for Molecular Medicine, Genetics, and Inherited Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, P O Box 22979, Manama, Bahrain
    J Clin Endocrinol Metab 90:5104-9. 2005
    ....
  43. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012
    ..Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes...
  44. doi From Type 1, through LADA, to type 2 diabetes: a continuous spectrum?
    J Lin
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Ann N Y Acad Sci 1150:99-102. 2008
    ..The preliminary data demonstrated that the susceptible haplotypes of the HLA-DQ gene present a continuous spectrum from typical T1DM, through LADA, to T2DM, which deserves further investigation...
  45. doi An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Pediatr Diabetes 11:386-93. 2010
    ....
  46. pmc Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study
    Suzanne K Cordovado
    Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F 24, Atlanta, GA 30341, USA
    Diabetes 57:518-22. 2008
    ..The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy...
  47. ncbi VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile
    Diego Garcia
    Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute, University of Chile, Santiago, Chile
    Diabetes Res Clin Pract 77:134-40. 2007
    ....
  48. ncbi Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence
    R Hermann
    JDRF Center for Prevention of Type I Diabetes in Finland, University of Turku, Turku, Finland
    Diabetes Metab Res Rev 20:322-9. 2004
    ..To develop screening strategies for identification of individuals at increased genetic risk for type 1 diabetes in three populations with variable disease incidence rates and distinct ethnic origin...
  49. ncbi The role of HLA molecules in susceptibility to chronic rheumatic heart disease
    H Kudat
    Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    Int J Immunogenet 33:41-4. 2006
    ..The HLA-DRB1*13, DRB5* and DRB3* were protective against the development of rheumatic valve damage...
  50. ncbi Does HLA genotype influence the relative risk of Type 1 diabetes conferred by dietary factors?
    L C Stene
    Diabet Med 19:429-31. 2002
  51. doi HLA-DR-DQ haplotypes and type 1 diabetes in Macedonia
    Jorma Ilonen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Hum Immunol 70:461-3. 2009
    ....
  52. doi Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
    A G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Diabetologia 55:1937-43. 2012
    ..Seroconversion to islet autoantibodies precedes type 1 diabetes. This study aimed to identify periods of high seroconversion incidence, which could be targeted for mechanistic and therapeutic studies...
  53. ncbi NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children
    Ondrej Cinek
    Second Department of Paediatrics, Second Faculty of Medicine, Charles University, V Uvalu 84, Prague 5 CZ 150 06, Czech Republic
    Diabetes Res Clin Pract 60:49-56. 2003
    ..No association was observed for the Pro197His mutation which was carried by 5.3% cases and 5.9% controls. Our results confirm that the NEUROD Ala45Thr polymorphism is associated with childhood-onset Type 1 DM...
  54. ncbi MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Central de Asturias, C Celestino Villamil, 33 006 Oviedo, Spain
    Immunogenetics 53:989-91. 2002
    ..002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD...
  55. ncbi HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk prediction
    A G Rohana
    Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
    Med J Malaysia 66:133-7. 2011
    ..The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles...
  56. ncbi L-selectin gene T668C mutation in type 1 diabetes patients and their first degree relatives
    A Kretowski
    Department of Endocrinology, Medical School Biatystok, U1 M C Skl and z shtsls odowska Curie 24 a, 15 267, Bial and z shtsls ystok, Poland
    Immunol Lett 74:225-8. 2000
    ..highest frequency of F206L mutation in the EGF domain of L-selectin was observed in relatives with 'protective' HLA DQB1*0602 allele and nonDRB1*03-nonDRB1*04 haplotype, while in subjects with highest risk of IDDM haplotype the ..
  57. ncbi Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment
    A Zung
    Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel
    Hum Immunol 65:1463-8. 2004
    ..621, p = 0.04). We concluded that ongoing exposure of genetically predisposed immigrants from Ethiopia to diabetogenic environmental factors eventually leads to a high incidence of overt diabetes in this ethnic group...
  58. ncbi Immunogenetics of HLA class II in Israeli patients with adult-onset type 1 diabetes mellitus
    Dania Hirsch
    Department of Endocrinology, Rabin Medical Center, Beilinson Campus, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Immunol 68:616-22. 2007
    ..It may be concluded that the different ages of onset of T1D and its different forms of development in Israeli patients are apparently not caused by a different prevalence of HLA class II alleles...
  59. ncbi Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A
    Zdenek Sumnik
    Motol University Hospital, Charles University Prague, V Uvalu 84, CZ 150 06, Prague, The Czech Republic
    Diabetes Care 29:858-63. 2006
    ....
  60. ncbi The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1
    Zaheed Husain
    Immune Disease Institute, 800 Huntington Avenue, Boston, MA 02115, USA
    J Autoimmun 30:266-72. 2008
    ....
  61. doi Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University Vrije Universiteit Brussel VUB, Brussels, Belgium
    Hum Immunol 71:1233-7. 2010
    ..015). In conclusion, IL-2RA/CD25 is associated with type 1 diabetes in the Belgian population, independently of disease phenotype and other biologic markers...
  62. doi Variations of the perforin gene in patients with type 1 diabetes
    Elisabetta Orilieri
    Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
    Diabetes 57:1078-83. 2008
    ..The aim of this work was to investigate the role of PRF1 variations in type 1 diabetes...
  63. pmc MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus
    N J McHugh
    Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, Somerset BA1 1RL UK
    Ann Rheum Dis 65:488-94. 2006
    ..To conduct a case-control study to investigate whether there are independent tumour necrosis factor alpha (TNFalpha) or lymphotoxin alpha (LTalpha) haplotype associations with SLE or with any of the major serological subsets of SLE...
  64. pmc Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Ana M Wägner
    Endocrinology Department, Complejo Hospitalario Universitario Insular Materno Infantil, de Gran Canaria, Spain
    Diabetes Metab Res Rev 27:493-8. 2011
    ..The aim of this study was to find predictors of AAIDs in the Type 1 Diabetes Genetics Consortium data set...
  65. pmc Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes
    Taylor M Triolo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 94:4517-23. 2009
    ..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D...
  66. ncbi The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects
    Jan E van Autreve
    Diabetes Research Center, Molecular Diagnosis, Vrije Universteit Brussel, B 1070 Brussels, Belgium
    Hum Immunol 65:729-36. 2004
    ..These results are compatible with an effect of cis-encoded heterodimers or with previously suggested interactions of X-linked genetic factors with (DR3-)DQB1*02 haplotypes...
  67. doi The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus
    A Papadopoulou
    Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, Lund University CRC, Malmo, Sweden
    Diabetologia 52:1339-42. 2009
    ..We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes...
  68. pmc HLA genotyping in the international Type 1 Diabetes Genetics Consortium
    Josyf C Mychaleckyj
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Clin Trials 7:S75-87. 2010
    ....
  69. ncbi HLA-DRB1 and MHC class 1 chain-related A haplotypes in Basque families with celiac disease
    J R Bilbao
    Endocrinology and Diabetes Research Unit, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Tissue Antigens 60:71-6. 2002
    ..Finally, the major histocompatibility complex region's conferred susceptibility to CD, at least in Basque, is very similar to that observed for DM1, with shared risk and protective haplotypes...
  70. pmc Autoimmune type 1 diabetes genetic susceptibility encoded by human leukocyte antigen DRB1 and DQB1 genes in Tunisia
    Mouna Stayoussef
    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    Clin Vaccine Immunol 16:1146-50. 2009
    ....
  71. ncbi Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population
    Zsofia Gombos
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Hum Immunol 67:714-21. 2006
    ..Another locus close to D6S273 may also have an effect. For the first time we report that a locus near the C143 marker appear to affect disease association of the DRB1*08-DQB1*04 haplotype...
  72. ncbi HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients
    Elisabet Agardh
    Department of Ophthalmology, University Hospital MAS, SE 205 02 Malmo, Sweden
    J Diabetes Complications 18:32-6. 2004
    ....
  73. ncbi Fetal growth is increased by maternal type 1 diabetes and HLA DR4-related gene interactions
    M Hummel
    Institute of Diabetes Research and Academic Hospital Schwabing, Kolner Platz 1, 80804, Munchen, Germany
    Diabetologia 50:850-8. 2007
    ..The aim of this study was to determine whether HLA DR4 was associated with increased birthweight in a maternal diabetes environment and whether effects persisted during early childhood...
  74. ncbi Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA
    H Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    Biochem Biophys Res Commun 279:494-9. 2000
    ..These reciprocal actions between Tat and CIITA not only explains the functional impairment of APC in HIV-1 infection but also rationalizes the suppression of HIV-1 virus load by induction of CIITA such as IFN-gamma...
  75. doi Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex
    M K Viken
    Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Genes Immun 10:323-33. 2009
    ..Taken together, our results identify PRSS16 and BTN3A2, two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for T1D...
  76. pmc Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes
    Kati Lipponen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Diabetes 59:3253-6. 2010
    ..To test this hypothesis we analyzed the role of HLA class I and class II gene polymorphisms in the progression from diabetes-associated autoimmunity to clinical disease...
  77. ncbi TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ
    Folefac Aminkeng
    Diabetes Research Center, Molecular Diagnosis Unit, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 68:690-7. 2007
    ....
  78. ncbi HLA-DRB1, DQB1, and DQA1 allele profile in Brazilian patients with type 1 diabetes mellitus
    A P M Fernandes
    Department of General and Specialized Nursing, School of Nursing of Ribeirao Preto, University of Sao Paulo, 14 049 902, Ribeirao Preto, Sao Paulo, Brazil
    Ann N Y Acad Sci 958:305-8. 2002
    ..In addition to HLA-DRB1*15 and DQB1*0602 alleles, DRB1*11, DRB1*13, and DQA1*01 allele groups were associated with protection against the development of type 1 diabetes in Brazilian patients...
  79. pmc HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis
    Boel Brynedal
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 2:e664. 2007
    ..These findings imply complex autoimmune mechanisms involving both the regulatory and the effector arms of the immune system in the triggering of MS...
  80. doi Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families
    M C Eike
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Genes Immun 10:141-50. 2009
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex...
  81. pmc In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype
    Hector Chinoy
    Rheumatic Diseases Centre, Hope Hospital, Salford, UK
    Arthritis Res Ther 8:R13. 2006
    ..In conclusion, these findings support the notion that myositis patients with differing myositis serology have different immunogenetic profiles, and that these profiles may define specific myositis subtypes...
  82. ncbi Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort
    Shu Li
    Vaccine Laboratory, Nankai University, Tianjin, China
    J Acquir Immune Defic Syndr 44:121-31. 2007
    ..These data contribute to the database of allele frequencies and associations with HIV infection in the Chinese population...
  83. pmc Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
    Christian Siebold
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:1999-2004. 2004
    ..In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role...
  84. pmc Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
    E Mignot
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304, USA
    Am J Hum Genet 68:686-99. 2001
    ..Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy...
  85. pmc Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans
    Jorge R Oksenberg
    Department of Neurology, University of California at San Francisco, San Francisco, CA 94143 0435, USA
    Am J Hum Genet 74:160-7. 2004
    ..This finding is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin...
  86. ncbi Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort
    A Kupila
    Dept of Paediatrics, Univ of Turku, Kiinamyllynkatu 4 8, FIN 20520 Turku, Finland
    Diabetologia 44:290-7. 2001
    ..Population-wide genetic screening of susceptibility to multifactorial diseases will become relevant as knowledge of the pathogenesis of these diseases increases and preventive interventions are identified...
  87. pmc HLA class II associations with rheumatic heart disease among clinically homogeneous patients in children in Latvia
    Valda Stanevicha
    Department of Pediatrics, Riga Stradins University, Riga, Latvia
    Arthritis Res Ther 5:R340-6. 2003
    ..In Sydenham's chorea patients, the DQB1*0401-2 allele was more frequent. Genotyping control showed a high risk of RF and RHD in patients with DRB1*01-DQB1*0301-DRB1*07-DQB1*0302 and DRB1*15-DQB1*0302-DRB1*07-DQB1*0303...
  88. pmc HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine
    Inna G Ovsyannikova
    Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA
    Vaccine 27:3349-58. 2009
    ....
  89. ncbi HLA class II polymorphism in Egyptian children with lymphomas
    Y Al-Tonbary
    Hematology Oncology Unit, Mansoura University Children s Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt
    Hematology 9:139-45. 2004
    ..Strong arguments supporting genetic linkage between susceptibility to lymphomas and human leukocyte antigens (HLA)-class II are reported and give a clue about susceptibility or protection from the disease...
  90. ncbi HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination
    Chengbin Wang
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Hepatology 39:978-88. 2004
    ..In conclusion, DRB1*07 (or a closely linked allele) and immunoregulatory cytokine gene polymorphisms correlate with variable immune response to recombinant HBV vaccines...
  91. doi HLA-DQ association and allele competition in Chinese narcolepsy
    F Han
    Department of Pulmonary Medicine, Beijing University People s Hospital, Beijing, China
    Tissue Antigens 80:328-35. 2012
    ....
  92. ncbi Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients
    Satoshi Murao
    Matsuyama Shimin Hospital, Ehime, Japan
    Diabetes 53:2684-90. 2004
    ....
  93. pmc Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility
    Matthew R Lincoln
    University Department of Clinical Neurology, Third Floor, West Wing, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:7542-7. 2009
    ..MHC disease associations may be more generally haplotypic or diplotypic...
  94. pmc HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia
    Eleonora Cocco
    Department Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy
    PLoS ONE 7:e33972. 2012
    ....
  95. pmc Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls
    Frank C Arnett
    Division of Rheumatology, Department of Internal Medicine, The University of Texas Health Science Center at Houston UTHSC H, 6431 Fannin Street, MSB 5 270, Houston, TX 77030, USA
    Ann Rheum Dis 69:822-7. 2010
    ....
  96. pmc Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)
    Vincent Butty
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:2348-59. 2008
    ....
  97. ncbi A genome-wide search for human type 1 diabetes susceptibility genes
    J L Davies
    Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Headington, UK
    Nature 371:130-6. 1994
    ..In addition to IDDM1 (in the major histocompatibility complex on chromosome 6p21) and IDDM2 (in the insulin gene region on chromosome ..
  98. ncbi Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis
    Ejaz A Shamim
    Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
    Arthritis Rheum 46:1885-93. 2002
    ....
  99. pmc Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A
    J M M Howson
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Diabetes Obes Metab 11:31-45. 2009
    ..Here we test for HLA class II-independent associations in the MHC using fine mapping data generated by the Type 1 Diabetes Genetics Consortium (T1DGC)...
  100. ncbi HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Rheumatology (Oxford) 46:1786-91. 2007
    ..To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization...
  101. ncbi HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China
    E Trachtenberg
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 70:455-63. 2007
    ....

Research Grants62

  1. DECREASING SEVERITY OF RECURRENT HEPATITIS C IN LIVER
    Lakshmi Gaur; Fiscal Year: 1999
    ....
  2. HLA-DQ Sequencing Studies in Narcolepsy/Hypocretin Deficiency
    Emmanuel J Mignot; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE (provided by applicant): Narcolepsy affects 1/2000 Americans and is a common neurological disorder. The proposed study may lead to new therapeutic avenues for the disorder. ..
  3. Genetic Susceptibility to Cervical Cancer
    Janet Rader; Fiscal Year: 2009
    ..We will select candidate genes that appear critical for the development of the cancer, including the HLA DQB1/DRB1 locus and other immune markers, genes that are cellular targets of HPV E6, E7, and E5 oncoproteins, and ..
  4. Mechanisms and Correlates of Immune Protection against Genital Chlamydia in Human
    William M Geisler; Fiscal Year: 2013
    ..Study findings should provide systemic and mucosal immune correlates of protection needed for CT vaccine studies. ..
  5. Role of Non-Core RAG1 in DSB Repair, Cell Survival, and Cell Cycle Progression
    Julie Horowitz; Fiscal Year: 2013
    ..proteins each consist of "core" endonuclease regions, and "non-core" regions required for normal assembly of lymphocyte antigen receptors and normal early lymphocyte development...
  6. LOCALIZED REVISION OF EPIGENETIC LANDSCAPES INDUCED BY DNA DOUBLE-STRAND BREAKS
    Barry P Sleckman; Fiscal Year: 2012
    ..maps of DSB-induced changes to histone PTMs spanning several Mb using a custom microarray that contains all lymphocyte antigen receptor loci...
  7. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2012
    ..two funding cycles of this grant, we have characterized the molecular structure and function of Cutaneous Lymphocyte Antigen or CLA...
  8. ATM FUNCTION DURING V(D)J RECOMBINATION
    Barry P Sleckman; Fiscal Year: 2013
    ..We have shown that ATM is also involved in the repair of RAG-mediated DSBs generated during lymphocyte antigen receptor gene assembly...
  9. ACTIVATION OF CELLULAR SIGNALING PATHWAYS BY DNA DOUBLE STRAND BREAKS
    Barry P Sleckman; Fiscal Year: 2013
    ..meiosis and the generation (VDJ recombination) and diversification (class switch recombination) of lymphocyte antigen receptor genes...
  10. CXCR4 CHEMOKINE RECEPTOR REGULATION OF ERK MAP KINASE
    Karen E Hedin; Fiscal Year: 2013
    ..provided by applicant): Extensive cross-regulation of immune function has been reported between the T lymphocyte antigen receptor (TCR) that mediates T cell immune activation, and CXCR4, a chemokine receptor that stimulates cell ..
  11. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..selected for binding to clusters of major histocompatability class (MHC) motifs representing multiple human lymphocyte antigen (HLA) alleles (promiscuous epitopes) and effective with each of the four dengue serotypes (pan-dengue ..
  12. Pulmonary Interactions with Innate Immunity
    DAVID LINN PERKINS; Fiscal Year: 2013
    ..Also, we investigate evidence that cytotoxic t-lymphocyte antigen 4 (CTLA4), an inhibitor of T cells, mediates SP-D effects...
  13. STREP, HOST FACTORS, AUTOANTIBODIES & TOURETTE SYNDROME
    Harvey Singer; Fiscal Year: 2000
    ..Aim 6 will assess whether the presence of the B lymphocyte antigen D8/17 is a genetic susceptibility "fingerprint" specific for the TS-PANDAS group...
  14. Anti-CTLA-4 Monoclonal Antibody Therapy for Lymphoma
    John Timmerman; Fiscal Year: 2005
    ..T cell hyporesponsiveness towards tumors is blockade of the negative T cell regulatory molecule cytotoxic T lymphocyte antigen 4 (CTLA-4)...
  15. HUMAN T LYMPHOCYTE RESPONSE TO VIRAL ANTIGENS
    Thomas Braciale; Fiscal Year: 1991
    ..amino acids necessary for binding to class I or class II MHC gene products and/or interaction with T lymphocyte antigen receptors...
  16. SPONTANEOUS REGRESSION BIOMARKERS IN CERVIX DYSPLASIA
    Gloria Ho; Fiscal Year: 2003
    ..HPV types 6, 16, 18, 31, 53, and 58, (2) cell-mediated immunity (CMI) to HPV 16 E6 and E7 peptides, (3) class II HLA DQB1 and DRB1 alleles, (4) plasma ascorbic acid level, and (5) red blood cell (RBC) folate level...
  17. Degeneracy and Complexity in the Immune System
    Eli Sercarz; Fiscal Year: 2006
    ..Actually, most of the crucial receptor elements in the immune system, aside from lymphocyte antigen receptors, are degenerate to a great extent, e.g...
  18. Characterization of V(D)J cleavage and repair complexes
    PATRICK SWANSON; Fiscal Year: 2007
    Diversity in the vertebrate lymphocyte antigen receptor repertoire is largely achieved by a process termed V(D)J recombination that assembles antigen receptor genes from arrays of component gene segments by a series of site-specific DNA ..
  19. HPV AND CERVIX NEOPLASIA--A CASE CONTROL STUDY
    Hans Olov Adami; Fiscal Year: 1999
    ..These data will be used on a number of different analyses including conditional logistic regression. ..
  20. CCR4 IN SKIN LYMPHOCYTE HOMING AND IMMUNITY
    James Campbell; Fiscal Year: 2000
    ..attract circulating systemic memory T cells, especially skin-homing T cells expressing the cutaneous lymphocyte antigen, CLA. In contrast, intestinal (alpha4beta7+) memory and naive T cells respond poorly...
  21. Bimp3 in Antigen Receptor Signaling and MALT Lymphoma
    LINDA MCALLISTER LUCAS; Fiscal Year: 2007
    ..assemble the signaling molecules that are required for Bcl10/MALT1-mediated NF-(B activation in response to lymphocyte antigen receptor stimulation...
  22. GENETIC CONTROL OF BB RAT AUTOIMMUNITY
    Ake Lernmark; Fiscal Year: 2009
    ..the complexity of human and NOD mouse T1D, onset in the BB rat is limited to five genes;the MHC on chromosome 20 (Iddm1), lyp (Ian5) (Iddm2) on chromosome 4 and three susceptibility factors on chromosomes 2 (IddmS), 4 (Iddm4) and 15 (..
  23. Multifactorial Genetic Disease Model:Schizophrenial/HLA
    Wendie Robbins; Fiscal Year: 2003
    ..The candidate lacks the training necessary for research at the gene or gene and gene/environment interaction level. Schizophrenia (as an example of a complex genetic disorder) will provide an excellent model for training. ..
  24. GENETICS OF HUMAN LYMPHOCYTE ANTIGEN CD8
    Paula Kavathas; Fiscal Year: 2001
    ..These cells have promise as immunotherapeutic agents by in vitro sensitization and injection into patients. Being able to target genes to this lineage could enhance the ability to develop these cells for immunotherapy. ..
  25. Structure Function Analysis of T Cell E-Selectin Ligands
    Robert Fuhlbrigge; Fiscal Year: 2007
    ..trafficking to sites of cutaneous inflammation has been closely associated with expression of the cutaneous lymphocyte antigen (CLA), a carbohydrate epitope that serves as an E-selectin ligand on T cells and mediates the first, crucial ..
  26. IMMUNOLOGY OF A MAJOR IDIOTYPE
    Jan Cerny; Fiscal Year: 1980
    ..Id is a specific determinant present on variable regions of lymphocyte antigen receptors as well as on the specific lymphocyte products...
  27. Immunosuppression and regulatory T cells in aging
    Claire Chougnet; Fiscal Year: 2006
    ..This subset of T cells constitutively express CD25, cytotoxic T-lymphocyte antigen-4 (CTLA-4) and the TNF receptor family member GITR...
  28. Regulation of NK Cell Function by Vav-family Proteins
    Wojciech Swat; Fiscal Year: 2006
    ..guanine nucleotide exchange factors and molecular adaptors that play a key role in signal transduction of lymphocyte antigen receptors...
  29. GENETICS OF T-LYMPHOCYTE ANTIGEN RECEPTORS
    Edward Palmer; Fiscal Year: 1992
    ..Finally, we will study the effects of background genes on the positive selection of a single T cell receptor in a T cell receptor transgenic mouse...
  30. BIOLOGIC & CLINICAL PROPERTIES OF CD4 STRUCTURAL ANALOGS
    Neal Flomenberg; Fiscal Year: 2001
    ..The composite information gained should allow assessment of the efficacy of the present generation of CD4 analogs as well as the design and preclinical testing of next generation products. ..
  31. GENE ENVIRONMENT INTERACTIONS IN SCHIZOPHRENIA
    Vishwajit Nimgaonkar; Fiscal Year: 2002
    ..risk factors for schizophrenia Initially, it is proposed to test-I association of schizophrenia with the HLA DQB1 locus using family based studies...
  32. CTLA-4 Inhibition and Autoimmunity in Melanoma
    Jeffrey Weber; Fiscal Year: 2008
    ..abstract_text> ..
  33. IN VITRO/IN VIVO ACTIVATED DENDRITIC CELLS FOR MELANOMA
    Jeffrey Weber; Fiscal Year: 2003
    ....
  34. Dendritic Cell Vaccination During Lymphoid Reconstitution
    Jeffrey Weber; Fiscal Year: 2008
    ..Toxicity as well as clinical response will be secondary endpoints. The cohort with the optimal level of immune response will be taken forward in future studies. ..
  35. IL-12 as an Adjuvant for a Melanoma Peptide Vaccine
    Jeffrey Weber; Fiscal Year: 2003
    ..The results of those assays will be used to design randomized phase III trials for resected high risk melanoma and to develop strategies for overcoming antigen-specific unresponsiveness in melanoma patients. ..
  36. HPV DNA VACCINE FOR CERVICAL PRE NEOPLASIA
    Jeffrey Weber; Fiscal Year: 2003
    ..To insure that spontaneous regression does not account for a portion of the responses, baseline measurements will be followed one month later by a second set of assessments prior to the start of the vaccine. ..
  37. The function of membrane vesiculation in CTLA-4-mediate*
    Joonsoo Kang; Fiscal Year: 2005
    ..Cytotoxic T lymphocyte antigen-4 (CTLA-4) is a member of the CD28 costimulation family that is a critical regulator of T cell activation ..
  38. SCHIZOPHRENIA--GENETIC ASSOCIATIONS IN AFRICAN-AMERICANS
    Vishwajit Nimgaonkar; Fiscal Year: 1999
    ..i) a positive association at the dopamine D3 receptor gene (D3RG) locus, (ii) a negative association at the HLA DQB1 gene locus...
  39. NEW GENETIC MARKERS FOR INSULIN-DEPENDENT DIABETES
    MICHAEL SHEEHY; Fiscal Year: 1990
    ..Since HLA molecules and T-lymphocyte antigen receptors cooperate intimately in cell-mediated immunity, we postulate that the pertinent non-HLA genes may ..
  40. REG. OF T CELL AUTOREACTIVITY IN IDDM BY CTLA-4/CD152
    Jon Piganelli; Fiscal Year: 2001
    ..immunoregulatory defects, one of which is deficient expression and function of the molecule, cytotoxic T lymphocyte antigen 4 (CTLA- 4/CD152) on T cells...
  41. FUNCTIONAL T CELL RECEPTOR GAMMA DELTA CELLS & GENES
    CHRISTINA PARKER; Fiscal Year: 1993
    ..TCR alpha beta lymphocyte antigen recognition is known to be restricted by major histocompatibility (MHC) antigens, but the nature of the ..
  42. MODULATION OF A DIABETES GENE BY VIRAL TRANSACTIVATION
    Gerald Nepom; Fiscal Year: 2001
    ..activators on the tissue specific expression of the DQB1 allele? - What are the functional consequences of the influence of adenoviral E1a expression and resulting modulation of DQB1 expression on T-cell activation in vitro? ..
  43. INDO/US COLLABORATION IN SCHIZOPHRENIA GENETICS
    Vishwajit Nimgaonkar; Fiscal Year: 1999
    ..Using case-control studies, variation at two loci (HLA DQB1 and the dopamine D3 receptor, DRD3), have been associated previously with susceptibility to schizophrenia...
  44. SNPs in Lung Cancer Risk and Therapeutic Response
    Effie Petersdorf; Fiscal Year: 2004
    ..abstract_text> ..
  45. OPTIMIZING BMT FOR CANCER BY GENETIC MATCHING OF DONORS
    Effie Petersdorf; Fiscal Year: 2003
    ....
  46. Hepatitis B treatment and HIV Infection in resources limited settings
    Chloe L Thio; Fiscal Year: 2010
    ..This proposal has a high likelihood for success given the investigative team's experience, the randomized clinical trial design, and the nesting in an existing study. ..
  47. Inflammation Pathways in Breast Cancer
    Margaret M Madeleine; Fiscal Year: 2010
    ..Cytokine genes are expressed at different levels in older compared to younger women;therefore, we will also evaluate their contribution to breast cancer risk by levels of common exposures such as obesity and HRT use. ..
  48. Chlamydia trachomatis and Cervical Cancer
    MARGARET MADELEINE; Fiscal Year: 2003
    ..trachomatis may become a higher public health priority. Furthermore, our results would help determine whether further follow up of the C. trachomatis and cervical cancer association is warranted in a more expensive, prospective setting. ..
  49. Genetic Epidemiology of Adult Brain Cancer: A Follow-up Study
    Jianming Tang; Fiscal Year: 2008
    ..abstract_text> ..
  50. Liver Disease and HIV-HBV Coinfection in the HAART era
    Chloe Thio; Fiscal Year: 2008
    ..Given the experience of the investigative team and the well-characterized cohorts involved, the results from this proposal will yield insights into the management of HIV-HBV co-infected patients. ..
  51. Hypocretin System Immune Diathesis in Human Narcolepsy
    John Black; Fiscal Year: 2004
    ..The cause of human narcolepsy is unknown. Human narcolepsy is associated with HLA DQB1*0602, is rarely familial, and has been associated with a mutation in only one case to date...
  52. DNA Methylation as an Epigenetic Host Factor in HIV/AIDS
    Jianming Tang; Fiscal Year: 2006
    ..abstract_text> ..
  53. HLA-DP SEQUENCE POLYMORPHISM AND DISEASE PREDISPOSITION
    Henry Erlich; Fiscal Year: 2003
    ..This method will be applied to HPV-infected cervical samples and an in vitro system with GAD peptide stimulation to study the HLA associations with cervical cancer and type 1 diabetes. ..
  54. Identification of Measles Class II-Restricted Peptides
    INNA OVSYANNIKOVA; Fiscal Year: 2003
    ..The basis from which this proposal will build on is outlined in the background, significance, and preliminary data sections below. ..
  55. CHEMOIMMUNOTHERAPY FOR BREAST CANCER TREATMENT
    Leisha Emens; Fiscal Year: 2006
    ..abstract_text> ..
  56. Maternal Microchimerism in Renal Disease
    Anne Stevens; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  57. Chicago Childhood Diabetes Registry
    Rebecca Lipton; Fiscal Year: 2007
    ..Ultimately, this approach will permit a truly population-based molecular epidemiologic study of early-onset diabetes in families from a range of ethnic groups. ..
  58. Regulation of the Immune Response to Prostate Cancer
    Charles Drake; Fiscal Year: 2007
    ..Finally, the research and training program outlined in this proposal makes full use of the collaborative and educational opportunities offered by the Johns Hopkins Oncology Center, where this work will be performed. ..
  59. The role of copy number variants (CNV) in type 1 diabetes
    Stephen Rich; Fiscal Year: 2009
    ..Identification of genetic risk factors for T1D is the first step in risk prediction, intervention and developing disease therapeutics (prevention). ..
  60. Immunogenetic Studies of Autoimmune Disease
    Lisa Barcellos; Fiscal Year: 2008
    ..The results obtained from this study will provide a strong and much needed foundation for future molecular studies of MC and maternal-fetal relationships in autoimmunity. ..