HLA-DQB1

Summary

Gene Symbol: HLA-DQB1
Description: major histocompatibility complex, class II, DQ beta 1
Alias: CELIAC1, HLA-DQB, IDDM1, HLA class II histocompatibility antigen, DQ beta 1 chain, MHC class II DQ beta chain, MHC class II HLA-DQ beta glycoprotein, MHC class II antigen DQB1, MHC class II antigen HLA-DQ-beta-1
Species: human
Products:     HLA-DQB1

Top Publications

  1. Ovsyannikova I, Vierkant R, Pankratz V, O Byrne M, Jacobson R, Poland G. HLA haplotype and supertype associations with cellular immune responses and cytokine production in healthy children after rubella vaccine. Vaccine. 2009;27:3349-58 pubmed publisher
  2. McElroy J, Cree B, Caillier S, Gregersen P, Herbert J, Khan O, et al. Refining the association of MHC with multiple sclerosis in African Americans. Hum Mol Genet. 2010;19:3080-8 pubmed publisher
  3. Conde L, Halperin E, Akers N, Brown K, Smedby K, Rothman N, et al. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet. 2010;42:661-4 pubmed publisher
    ..We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9)). ..
  4. Rubicz R, Yolken R, DRIGALENKO E, Carless M, Dyer T, Bauman L, et al. A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). PLoS Genet. 2013;9:e1003147 pubmed publisher
    ..The significance of this work is that a major locus related to EBV infection has been identified, which may ultimately reveal the underlying mechanisms by which the immune system regulates infection with this pathogen. ..
  5. Sulcebe G, Sanchez Mazas A, Tiercy J, Shyti E, Mone I, Ylli Z, et al. HLA allele and haplotype frequencies in the Albanian population and their relationship with the other European populations. Int J Immunogenet. 2009;36:337-43 pubmed publisher
    ..When compared with other populations, their distribution frequencies show close similarities with neighbouring populations of the entire Balkan area. ..
  6. Jinam T, Saitou N, Edo J, Mahmood A, Phipps M. Molecular analysis of HLA Class I and Class II genes in four indigenous Malaysian populations. Tissue Antigens. 2010;75:151-8 pubmed publisher
    ..These results showed the scope of HLA diversity in these indigenous minority groups and may prove beneficial for future disease association, anthropological and forensic studies. ..
  7. Guzalinuer A, Mihrinsa A, Zhang S, Li H, Gulishare N, Zhang G. [Association between HPV infection and HLA-DQB1 alleles polymorphism in the cervical carcinogenesis in Uyghur women in southern Xinjiang]. Zhonghua Zhong Liu Za Zhi. 2010;32:492-6 pubmed
    ..The study of HLA alleles in the cervical carcinogenesis in Uyghur women may play an important role in the intervention research of cervical cancer. ..
  8. Smedby K, Foo J, Skibola C, Darabi H, Conde L, Hjalgrim H, et al. GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma. PLoS Genet. 2011;7:e1001378 pubmed publisher
    ..These findings suggest that the HLA class II region plays a complex yet important role in NHL. ..
  9. Cangussu L, Teixeira R, Campos E, Rampim G, Mingoti S, Martins Filho O, et al. HLA class II alleles and chronic hepatitis C virus infection. Scand J Immunol. 2011;74:282-287 pubmed publisher

More Information

Publications122 found, 100 shown here

  1. Chen D, McKay J, Clifford G, Gaborieau V, Chabrier A, Waterboer T, et al. Genome-wide association study of HPV seropositivity. Hum Mol Genet. 2011;20:4714-23 pubmed publisher
    ..This study provides a proof of principle that genetic variation plays a role in antibody reactivity to HPV infection. ..
  2. Cocco E, Sardu C, Pieroni E, Valentini M, Murru R, Costa G, et al. HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia. PLoS ONE. 2012;7:e33972 pubmed publisher
    ..The data also supports a functional role for specific residues of the DRB1 and DQB1 proteins in predisposing patients to MS. ..
  3. Valdes A, Thomson G. Several loci in the HLA class III region are associated with T1D risk after adjusting for DRB1-DQB1. Diabetes Obes Metab. 2009;11 Suppl 1:46-52 pubmed publisher
    ..Our data confirm that the class III region is involved in T1D susceptibility and suggest that more than one gene in the region is involved. ..
  4. Radstake T, Gorlova O, Rueda B, Martin J, Alizadeh B, Palomino Morales R, et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet. 2010;42:426-9 pubmed publisher
    ..39 x 10(-9) in the combined analysis). Additionally, we confirm and firmly establish the role of the MHC (P = 2.31 x 10(-18)), IRF5 (P = 1.86 x 10(-13)) and STAT4 (P = 3.37 x 10(-9)) gene regions as SSc genetic risk factors. ..
  5. Mbarek H, Ochi H, Urabe Y, Kumar V, Kubo M, Hosono N, et al. A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population. Hum Mol Genet. 2011;20:3884-92 pubmed publisher
    ..03 and 5.02, respectively) as risk haplotypes. These findings indicated that variants in antigen-binding regions of HLA-DP and HLA-DQ contribute to the risk of persistent HBV infection. ..
  6. Liang J, Xu A, Xie Y, Awonuga A, Lin Z. Some but not all of HLA-II alleles are associated with cervical cancer in Chinese women. Cancer Genet Cytogenet. 2008;187:95-100 pubmed publisher
    ..17; 95% CI, 0.04-0.80) haplotype was significantly lower in the study patients compared with the controls and may confer a decreased risk of CC among Han race population in the Guangdong Province of China. ..
  7. Lincoln M, Ramagopalan S, Chao M, Herrera B, DeLuca G, Orton S, et al. Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. Proc Natl Acad Sci U S A. 2009;106:7542-7 pubmed publisher
    ..MHC disease associations may be more generally haplotypic or diplotypic. ..
  8. Ovsyannikova I, Jacobson R, Vierkant R, O Byrne M, Poland G. Replication of rubella vaccine population genetic studies: validation of HLA genotype and humoral response associations. Vaccine. 2009;27:6926-31 pubmed publisher
  9. Pettersen E, Skorpen F, Kvaløy K, Midthjell K, Grill V. Genetic heterogeneity in latent autoimmune diabetes is linked to various degrees of autoimmune activity: results from the Nord-Trøndelag Health Study. Diabetes. 2010;59:302-10 pubmed publisher
    ..004 and P = 0.004, respectively). Genetic heterogeneity in LADA is linked to various degrees of autoimmune activity and may be partly distinct from both type 1 and type 2 diabetes. ..
  10. Hor H, Kutalik Z, Dauvilliers Y, Valsesia A, Lammers G, Donjacour C, et al. Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy. Nat Genet. 2010;42:786-9 pubmed publisher
    ..Cases almost never carried a trans DRB1*1301-DQB1*0603 haplotype (odds ratio = 0.02; P < 6 x 10(-14)). This unexpected protective HLA haplotype suggests a virtually causal involvement of the HLA region in narcolepsy susceptibility...
  11. Howson J, Walker N, Clayton D, Todd J. Confirmation of HLA class II independent type 1 diabetes associations in the major histocompatibility complex including HLA-B and HLA-A. Diabetes Obes Metab. 2009;11 Suppl 1:31-45 pubmed publisher
    ..In addition, a robust statistical methodology that fully models the class II effects is necessary. Recursive partitioning is a useful tool for modelling these multiallelic systems. ..
  12. Ovsyannikova I, Ryan J, Vierkant R, O Byrne M, Pankratz V, Jacobson R, et al. Influence of host genetic variation on rubella-specific T cell cytokine responses following rubella vaccination. Vaccine. 2009;27:3359-66 pubmed publisher
  13. Kohaar I, Hussain S, Thakur N, Tiwari P, Nasare V, Batra S, et al. Association between human leukocyte antigen class II alleles and human papillomavirus-mediated cervical cancer in Indian women. Hum Immunol. 2009;70:222-9 pubmed publisher
    ..002) as well as cervical cancer (p(c) 0.01). Therefore, we have demonstrated that HLA DR-DQ polymorphisms are involved in genetic susceptibility to cervical cancer or HPV infection in a northern Indian population. ..
  14. Ward M, Hendrey M, Malley J, Learch T, Davis J, Reveille J, et al. Clinical and immunogenetic prognostic factors for radiographic severity in ankylosing spondylitis. Arthritis Rheum. 2009;61:859-66 pubmed publisher
    ..29). The accuracy of the prognosis of radiographic severity in AS is improved by knowing the age at disease onset, sex, smoking history, and the presence of HLA-B*4100, DRB1*0804, DQA1*0401, DQB1*0603, DRB1*0801, and DPB1*0202 alleles. ..
  15. van der Mei I, Ponsonby A, Taylor B, Stankovich J, Dickinson J, Foote S, et al. Human leukocyte antigen-DR15, low infant sibling exposure and multiple sclerosis: gene-environment interaction. Ann Neurol. 2010;67:261-5 pubmed publisher
    ..This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life. Ann Neurol 2009;66:261-265 ANN NEUROL 2010;67:259-263. ..
  16. Duggal P, Thio C, Wojcik G, Goedert J, Mangia A, Latanich R, et al. Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts. Ann Intern Med. 2013;158:235-45 pubmed publisher
    ..IL-28B and HLA class II are independently associated with spontaneous resolution of HCV infection, and SNPs marking IL-28B and DQB1*03:01 may explain approximately 15% of spontaneous resolution of HCV infection. ..
  17. Arnett F, Gourh P, Shete S, Ahn C, Honey R, Agarwal S, et al. Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls. Ann Rheum Dis. 2010;69:822-7 pubmed publisher
    ..These data indicate unique and multiple HLA-class II effects in SSc, especially on autoantibody markers of different subphenotypes. ..
  18. Simeon C, Fonollosa V, Tolosa C, Palou E, Selva A, Solans R, et al. Association of HLA class II genes with systemic sclerosis in Spanish patients. J Rheumatol. 2009;36:2733-6 pubmed publisher
    ..HLA alleles play a role in genetic susceptibility to SSc in Spanish patients. Some alleles are more prevalent in patients with pulmonary fibrosis and in patients with certain SSc-specific autoantibodies (anti-Topo I and ACA). ..
  19. Cozen W, Li D, Best T, Van Den Berg D, Gourraud P, Cortessis V, et al. A genome-wide meta-analysis of nodular sclerosing Hodgkin lymphoma identifies risk loci at 6p21.32. Blood. 2012;119:469-75 pubmed publisher
    ..In a separate analysis, the DRB1*0701 allele was associated with a decreased risk of NSHL (OR = 0.5, 95% confidence interval = 0.4, 0.7). These data support the importance of the HLA class II region in NSHL etiology. ..
  20. Han F, Lin L, Li J, Dong S, An P, Zhao L, et al. HLA-DQ association and allele competition in Chinese narcolepsy. Tissue Antigens. 2012;80:328-35 pubmed publisher
  21. Sanchez Velasco P, Leyva Cobian F. The HLA class I and class II allele frequencies studied at the DNA level in the Svanetian population (Upper Caucasus) and their relationships to Western European populations. Tissue Antigens. 2001;58:223-33 pubmed
    ..These observations suggest a mixture of alleles in Svans from geographically distinct areas, and probably do not support a common ancestor for these Caucasian inhabitants and people from Northern Spain. ..
  22. Marrosu M, Cocco E, Costa G, Murru M, Mancosu C, Murru R, et al. Interaction of loci within the HLA region influences multiple sclerosis course in the Sardinian population. J Neurol. 2006;253:208-13 pubmed
    ..These findings suggest that a locus telomeric to HLA class I exerts an effect on alleles at the DPB1 locus in modulating disease course. ..
  23. Motzo C, Contu D, Cordell H, Lampis R, Congia M, Marrosu M, et al. Heterogeneity in the magnitude of the insulin gene effect on HLA risk in type 1 diabetes. Diabetes. 2004;53:3286-91 pubmed
    ..the joint action of the two established type 1 diabetes susceptibility loci, the HLA class II DQB1 and DRB1 genes (IDDM1) and the insulin gene (INS) promoter (IDDM2)...
  24. Hermann R, Knip M, Veijola R, Simell O, Laine A, Akerblom H, et al. Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes--indication of an increased environmental pressure?. Diabetologia. 2003;46:420-5 pubmed
  25. Wedderburn L, McHugh N, Chinoy H, Cooper R, Salway F, Ollier W, et al. HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap. Rheumatology (Oxford). 2007;46:1786-91 pubmed
    ..In the future, a combination of serological and genetic typing may allow for better prediction of clinical course and disease subtype in JDM. ..
  26. Luongo V, Pirozzi G, Caraco C, Errico S, de Angelis F, Celentano E, et al. HLA allele frequency and clinical outcome in Italian patients with cutaneous melanoma. Tissue Antigens. 2004;64:84-7 pubmed
    ..A multivariate logistic regression model showed HLA-DRB1*04 to behave as an independent favorable prognostic marker of melanoma in our population (OR = 2.34, CI = 1.15-4.74). ..
  27. Shao W, Tang J, Dorak M, Song W, Lobashevsky E, Cobbs C, et al. Molecular typing of human leukocyte antigen and related polymorphisms following whole genome amplification. Tissue Antigens. 2004;64:286-92 pubmed
    ..General population genetic analyses provided additional evidence that WGA may represent a reliable and simple approach to securing ample genomic DNA for typing HLA, MICA, and related variants. ..
  28. Howson J, Dunger D, Nutland S, Stevens H, Wicker L, Todd J. A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene. Diabetologia. 2007;50:741-6 pubmed
  29. Evseeva I, Spurkland A, Thorsby E, Smerdel A, Tranebjaerg L, Boldyreva M, et al. HLA profile of three ethnic groups living in the North-Western region of Russia. Tissue Antigens. 2002;59:38-43 pubmed
    ..Genetic distances and correspondence analysis show that Pomors have a close relationship with Norwegians and Finns, whereas Nentsy and Saami are more closely related to Oriental populations. ..
  30. Butty V, Campbell C, Mathis D, Benoist C. Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1). Diabetes. 2008;57:2348-59 pubmed publisher
    ..In contrast, HLA DQB1*0302 and DQB1*0301 differed significantly in progressors versus nonprogressors (DQB*0302, 42.6 vs. 34.7%, P = 0...
  31. Kuwana M, Pandey J, Silver R, Kawakami Y, Kaburaki J. HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities. J Rheumatol. 2003;30:2392-7 pubmed
    ..Our results suggest that in patients with SSc, anti-RNAP I/III antibodies are composed of subsets defined by combinations of reactivities to individual RNAP subunits having specific HLA class II correlations. ..
  32. Katahira M, Ishiguro T, Segawa S, Kuzuya Nagao K, Hara I, Nishisaki T. Reevaluation of human leukocyte antigen DR-DQ haplotype and genotype in type 1 diabetes in the Japanese population. Horm Res. 2008;69:284-9 pubmed publisher
    ..DR4, DR8, DR9, and DR13 haplotypes confer susceptibility to type 1 diabetes in Japanese patients. ..
  33. Lampis R, Morelli L, Congia M, Macis M, Mulargia A, Loddo M, et al. The inter-regional distribution of HLA class II haplotypes indicates the suitability of the Sardinian population for case-control association studies in complex diseases. Hum Mol Genet. 2000;9:2959-65 pubmed
    ..These results indicate that robust case-control studies can be carried out in Sardinia offering cost efficiency over certain family-based designs. ..
  34. Jeong J, Hong S, Shin Y, Han J, Lee S. HLA-DQB1 allele and hypocretin in Korean narcoleptics with cataplexy. J Korean Med Sci. 2007;22:127-31 pubmed
  35. Graham R, Ortmann W, Langefeld C, Jawaheer D, Selby S, Rodine P, et al. Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet. 2002;71:543-53 pubmed
    ..We conclude that HLA class II haplotypes containing DRB1 and DQB1 alleles are strong risk factors for human SLE. ..
  36. Cinek O, Kolouskova S, Snajderova M, Sumnik Z, Sedlakova P, Drevinek P, et al. HLA class II genetic association of type 1 diabetes mellitus in Czech children. Pediatr Diabetes. 2001;2:98-102 pubmed
    ..Since none of the remaining DRB1*04 subtypes was associated with type 1 DM, our study may present another piece of evidence that the DRB1*0401 and DRB1*0404 alleles do not modify type 1 diabetes risk generally in European populations. ..
  37. Gillespie K, Bain S, Barnett A, Bingley P, Christie M, Gill G, et al. The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypes. Lancet. 2004;364:1699-700 pubmed
    ..003), especially in those diagnosed at age 5 years or younger, which is consistent with the hypothesis that the rise of type 1 diabetes is due to a major environmental effect. ..
  38. Horiki T, Ichikawa Y, Moriuchi J, Hoshina Y, Yamada C, Wakabayashi T, et al. HLA class II haplotypes associated with pulmonary interstitial lesions of polymyositis/dermatomyositis in Japanese patients. Tissue Antigens. 2002;59:25-30 pubmed
    ..0% vs 17.7%), and PM without PI (50.0% vs 5.5%). These results suggest that in terms of HLA class II association, Japanese DM and PM, and PM with and without PI, belong to different clinical groups. ..
  39. McKiernan S, Hagan R, Curry M, McDonald G, Kelly A, Nolan N, et al. Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology. 2004;40:108-14 pubmed
    ..More significantly, either HLA-A*03, -DRB1*0101, or -*0401 are carried by an overwhelming majority of those subjects who successfully clear HCV. ..
  40. Karell K, Louka A, Moodie S, Ascher H, Clot F, Greco L, et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum Immunol. 2003;64:469-77 pubmed
    ..These results underline the primary importance of HLA-DQ alleles in susceptibility to celiac disease, and the extreme rarity of celiac patients carrying neither the DQ2 or DQ8 heterodimers nor one half of the DQ2 heterodimer alone. ..
  41. Wang C, Tang J, Song W, Lobashevsky E, Wilson C, Kaslow R. HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination. Hepatology. 2004;39:978-88 pubmed
    ..In conclusion, DRB1*07 (or a closely linked allele) and immunoregulatory cytokine gene polymorphisms correlate with variable immune response to recombinant HBV vaccines. ..
  42. Yoshizawa K, Ota M, Saito S, Maruyama A, Yamaura T, Rokuhara A, et al. Long-term follow-up of hepatitis C virus infection: HLA class II loci influences the natural history of the disease. Tissue Antigens. 2003;61:159-65 pubmed
    ..Our findings establish that certain HLA class II alleles strongly influence disease progression following HCV infection. ..
  43. Motta P, Cech N, Fontan C, Giménez M, Lodeiro N, Marinic K, et al. [Role of HLA-DR and HLA-DQ alleles in multibacillary leprosy and paucibacillary leprosy in the province of Chaco (Argentina)]. Enferm Infecc Microbiol Clin. 2007;25:627-31 pubmed
    ..We attribute the differences between our findings and those of other authors to the fact that the Caucasian inhabitants of Chaco include a considerable mixture of South American natives (Guaraníes and Tobas). ..
  44. Madeleine M, Johnson L, Smith A, Hansen J, Nisperos B, Li S, et al. Comprehensive analysis of HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1 loci and squamous cell cervical cancer risk. Cancer Res. 2008;68:3532-9 pubmed publisher
    ..Thus, certain co-occurring alleles may be markers of disease risk that have clinical value as biomarkers for targeted screening or development of new therapies. ..
  45. Climent C, Nazario C, Umpierre S, Quintero M, Gorbea S. Major histocompatibility complex class II polymorphisms and risk of cervical cancer in Puerto Rican women. P R Health Sci J. 2007;26:97-101 pubmed
    ..These results should be confirmed in studies with larger sample size to preclude the possibility of false positive observations. ..
  46. Galeazzi M, Sebastiani G, Morozzi G, Carcassi C, Ferrara G, Scorza R, et al. HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets. Medicine (Baltimore). 2002;81:169-78 pubmed
  47. Redondo M, Babu S, Zeidler A, Orban T, Yu L, Greenbaum C, et al. Specific human leukocyte antigen DQ influence on expression of antiislet autoantibodies and progression to type 1 diabetes. J Clin Endocrinol Metab. 2006;91:1705-13 pubmed
    ..HLA DQ alleles determine autoantibody expression, which is correlated with diabetes progression. Among autoantibody-positive relatives, most HLA DQ genotypes did not further influence T1DM risk. ..
  48. Kang S, Park M, Song E, Kang S, Lee E, Song Y, et al. Association of HLA class II genes with systemic sclerosis in Koreans. J Rheumatol. 2001;28:1577-83 pubmed
  49. Uinuk Ool T, Takezaki N, Derbeneva O, Volodko N, Sukernik R. Variation of HLA class II genes in the Nganasan and Ket, two aboriginal Siberian populations. Eur J Immunogenet. 2004;31:43-51 pubmed
  50. Chan P, Cheung J, Cheung T, Lin C, Siu S, Yu M, et al. HLA-DQB1 polymorphisms and risk for cervical cancer: a case-control study in a southern Chinese population. Gynecol Oncol. 2007;105:736-41 pubmed
    ..In this study, the HLA DQB1 alleles among 221 southern Chinese women with cervical intraepithelial neoplasia grade III (CIN III)/invasive ..
  51. Spinola H, Brehm A, Bettencourt B, Middleton D, Bruges Armas J. HLA class I and II polymorphisms in Azores show different settlements in Oriental and Central islands. Tissue Antigens. 2005;66:217-30 pubmed
    ..The Central group of islands on the contrary clearly shows an influence of north Europeans (most probably derived from a well-documented Flemish settlement), with much less affinity to mainland Portugal. ..
  52. Thomson G, Valdes A, Noble J, Kockum I, Grote M, Najman J, et al. Relative predispositional effects of HLA class II DRB1-DQB1 haplotypes and genotypes on type 1 diabetes: a meta-analysis. Tissue Antigens. 2007;70:110-27 pubmed
    ..Our results show that meta-analyses and use of the P/C ratio and rankings thereof can be valuable in determining T1D risk factors at the haplotype and amino acid residue levels. ..
  53. De la Concha E, Fernandez Arquero M, Gual L, Vigil P, Martinez A, Urcelay E, et al. MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes. J Immunol. 2002;169:4637-43 pubmed
  54. Ellis M, Hetisimer A, Ruddy D, Hansen S, Kronmal G, McClelland E, et al. HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy. Immunogenetics. 1997;46:410-7 pubmed
    ..These results are consistent with other studies, suggesting that the HLA-DQ genes themselves are among the predisposing factors in narcolepsy. ..
  55. Mallal S, Nolan D, Witt C, Masel G, Martin A, Moore C, et al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet. 2002;359:727-32 pubmed
    ..1 ancestral haplotype. In our population, withholding abacavir in those with HLA-B*5701, HLA-DR7, and HLA-DQ3 should reduce the prevalence of hypersensitivity from 9% to 2.5% without inappropriately denying abacavir to any patient. ..
  56. Uinuk ool T, Takezaki N, Sukernik R, Nagl S, Klein J. Origin and affinities of indigenous Siberian populations as revealed by HLA class II gene frequencies. Hum Genet. 2002;110:209-26 pubmed
    ..The divergence time of the two clusters is estimated to be 21,000-24,000 years BP. Three different branches of the native Siberian peoples seem to have contributed founders for the indigenous American ethnic groups. ..
  57. Nagore E, Planelles M, Ledesma E, Millan J, Insa A, Oliver V, et al. Molecular genetic analysis of HLA-DR and -DQ alleles in Spanish patients with melanoma. Acta Derm Venereol. 2002;82:90-3 pubmed
    ..Our results indicate that HLA class II alleles may not contribute to a strong susceptibility to melanoma in the Spanish population, although further studies on larger series are needed to corroborate this. Key words: ..
  58. Klitz W, Maiers M, Spellman S, Baxter Lowe L, Schmeckpeper B, Williams T, et al. New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans. Tissue Antigens. 2003;62:296-307 pubmed
    ..Four DQA1-DQB1 haplotypes, all rare, are reported here for the first time. The haplotype frequency tables are suitable as a reference standard for HLA typing of the DR and DQ loci in European Americans. ..
  59. Siebold C, Hansen B, Wyer J, Harlos K, Esnouf R, Svejgaard A, et al. Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy. Proc Natl Acad Sci U S A. 2004;101:1999-2004 pubmed
    ..In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role. ..
  60. Hermann R, Laine A, Veijola R, Vahlberg T, Simell S, Lähde J, et al. The effect of HLA class II, insulin and CTLA4 gene regions on the development of humoral beta cell autoimmunity. Diabetologia. 2005;48:1766-75 pubmed
    ..Infants carrying increased risk HLA DQB1 genotypes were monitored for the appearance of autoantibodies (islet cell autoantibodies [ICA], insulin ..
  61. Ovsyannikova I, Pankratz V, Vierkant R, Jacobson R, Poland G. Human leukocyte antigen haplotypes in the genetic control of immune response to measles-mumps-rubella vaccine. J Infect Dis. 2006;193:655-63 pubmed
    ..002). Better characterization of such HLA profiles could inform and improve the design of novel epitope-rich vaccines and help to predict protective immune responses at the individual and population level. ..
  62. Barcellos L, Sawcer S, Ramsay P, Baranzini S, Thomson G, Briggs F, et al. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet. 2006;15:2813-24 pubmed
  63. Erlich H, Valdes A, Noble J, Carlson J, Varney M, Concannon P, et al. HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes. 2008;57:1084-92 pubmed publisher
    ..These data also indicate that the risk associated with specific HLA haplotypes can be influenced by the genotype context and that the trans-complementing heterodimer encoded by DQA1*0501 and DQB1*0302 confers very high risk. ..
  64. Rudy G, Lew A. The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells. J Immunol. 1997;158:2116-25 pubmed
    ..In neither case was DQA2 found to dimerize with an MHC class II beta-chain. Despite this, DQA2 is capable of forming a complex with invariant chain. ..
  65. Samaha H, Rahal E, Abou Jaoude M, Younes M, Dacchache J, Hakime N. HLA class II allele frequencies in the Lebanese population. Mol Immunol. 2003;39:1079-81 pubmed
    ..The presence of other common alleles is consistent with historical data showing that the Lebanese population is an admixture of various ethnicities. ..
  66. Jiang Y, Wang Y, Liu T, Liu J. Association between HLA class II gene and susceptibility or resistance to chronic hepatitis B. World J Gastroenterol. 2003;9:2221-5 pubmed
    ..These findings suggest that host HLA class II gene is an important factor determining the outcome of HBV infection. ..
  67. Oksenberg J, Barcellos L, Cree B, Baranzini S, Bugawan T, Khan O, et al. Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans. Am J Hum Genet. 2004;74:160-7 pubmed
    ..This finding is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin. ..
  68. Murao S, Makino H, Kaino Y, Konoue E, Ohashi J, Kida K, et al. Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients. Diabetes. 2004;53:2684-90 pubmed
  69. Giger J, Strickland O, Weaver M, Taylor H, Acton R. Genetic predictors of coronary heart disease risk factors in premenopausal African-American women. Ethn Dis. 2005;15:221-32 pubmed
    ..The premenopausal AAW in this sample had a higher than expected rate of metabolic syndrome, which was associated with DRB1 alleles. ..
  70. Malkki M, Single R, Carrington M, Thomson G, Petersdorf E. MHC microsatellite diversity and linkage disequilibrium among common HLA-A, HLA-B, DRB1 haplotypes: implications for unrelated donor hematopoietic transplantation and disease association studies. Tissue Antigens. 2005;66:114-24 pubmed
    ..Markers with high HSH values will be most informative in studies investigating MHC region disease-susceptibility genes where HLA haplotypic effects are known to exist. ..
  71. Kudat H, Telci G, Sozen A, Oguz F, Akkaya V, Ozcan M, et al. The role of HLA molecules in susceptibility to chronic rheumatic heart disease. Int J Immunogenet. 2006;33:41-4 pubmed
    ..The HLA-DRB1*13, DRB5* and DRB3* were protective against the development of rheumatic valve damage. ..
  72. Gilchrist F, Bunn C, Foley P, Lympany P, Black C, Welsh K, et al. Class II HLA associations with autoantibodies in scleroderma: a highly significant role for HLA-DP. Genes Immun. 2001;2:76-81 pubmed
    ..0000003). We have identified a significant association between the ATA and HLA-DPB1*1301 which may provide an insight into how this autoantibody is formed. Patient clinical characteristics depend on the autoantibodies they carry. ..
  73. Low A, Azmy I, Sharaf N, Cannings C, Wilson A. Association between two tumour necrosis factor intronic polymorphisms and HLA alleles. Eur J Immunogenet. 2002;29:31-4 pubmed
  74. Dubaniewicz A, Moszkowska G, Szczerkowska Z, Hoppe A. Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report. Thorax. 2003;58:890-1 pubmed
    ..21 to 0.71) in patients with TB than in controls. The occurrence of DQB1*03,*04,*06 alleles was similar in the two populations. The occurrence of specific DQB1 alleles may be linked to susceptibility/resistance to tuberculosis. ..
  75. Al Tonbary Y, Abdel Razek N, Zaghloul H, Metwaly S, El Deek B, El Shawaf R. HLA class II polymorphism in Egyptian children with lymphomas. Hematology. 2004;9:139-45 pubmed
  76. Lombard Z, Dalton D, Venter P, Williams R, Bornman L. Association of HLA-DR, -DQ, and vitamin D receptor alleles and haplotypes with tuberculosis in the Venda of South Africa. Hum Immunol. 2006;67:643-54 pubmed
  77. Dubaniewicz A, Moszkowska G. [Analysis of occurrence of DRB and DQ alleles in sarcoidosis and tuberculosis from Northern Poland]. Pneumonol Alergol Pol. 2007;75:13-21 pubmed
    ..In most cases, in SA patients frequency of HLA class II alleles occurrence is opposite to the frequency in TB patients. ..
  78. Brynedal B, Duvefelt K, Jonasdottir G, Roos I, Akesson E, Palmgren J, et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS ONE. 2007;2:e664 pubmed
    ..These findings imply complex autoimmune mechanisms involving both the regulatory and the effector arms of the immune system in the triggering of MS. ..
  79. Kawabata Y, Ikegami H, Kawaguchi Y, Fujisawa T, Shintani M, Ono M, et al. Asian-specific HLA haplotypes reveal heterogeneity of the contribution of HLA-DR and -DQ haplotypes to susceptibility to type 1 diabetes. Diabetes. 2002;51:545-51 pubmed
  80. Choi J, Lee K, Kim S, Shin E, Oh H, Suh C, et al. The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. Clin Exp Allergy. 2005;35:339-44 pubmed
    ..7%, P=0.0014) and normal controls (2.0%, P=0.0006). These findings suggest that the HLA-DRB1(*)1302-DQB1(*)0609-DPB1(*)0201 may be a strong genetic marker to determine the aspirin-induced urticaria phenotype. ..
  81. Lampis R, Morelli L, De Virgiliis S, Congia M, Cucca F. The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations. Tissue Antigens. 2000;56:515-21 pubmed
  82. Thomson W, Barrett J, Donn R, Pepper L, Kennedy L, Ollier W, et al. Juvenile idiopathic arthritis classified by the ILAR criteria: HLA associations in UK patients. Rheumatology (Oxford). 2002;41:1183-9 pubmed
    ..Although there are a number of common associations, each ILAR subgroup exhibits different patterns of HLA associations, suggesting that the ILAR classification system does define genetically distinct groups of patients. ..
  83. Ayed K, Gorgi Y, Ayed Jendoubi S, Bardi R. The involvement of HLA -DRB1*, DQA1*, DQB1* and complement C4A loci in diagnosing systemic lupus erythematosus among Tunisians. Ann Saudi Med. 2004;24:31-5 pubmed
    ..In contrast to other ethnic groups, MHC class II alleles are not associated with the presence of specific autoantibodies in Tunisian SLE patients. ..
  84. Donaldson P, Baragiotta A, Heneghan M, Floreani A, Venturi C, Underhill J, et al. HLA class II alleles, genotypes, haplotypes, and amino acids in primary biliary cirrhosis: a large-scale study. Hepatology. 2006;44:667-74 pubmed
    ..042, OR=0.65 in the UK patients; and 10% versus 31%, P=.00092, OR=0.25 in the Italian patients). In conclusion, a complex relationship exists between HLA and PBC, and some genetic associations may be population specific. ..
  85. Bourgey M, Calcagno G, Tinto N, Gennarelli D, Margaritte Jeannin P, Greco L, et al. HLA related genetic risk for coeliac disease. Gut. 2007;56:1054-9 pubmed
    ..An antenatal estimate of the order of risk of CD is now possible. Specific follow-up can thus be offered for babies at high risk. ..
  86. Pascual M, Nieto A, Lopez Nevot M, Ramal L, Mataran L, Caballero A, et al. Rheumatoid arthritis in southern Spain: toward elucidation of a unifying role of the HLA class II region in disease predisposition. Arthritis Rheum. 2001;44:307-14 pubmed
    ..A model involving both DQ and DR can best account for the contribution of HLA to RA. ..
  87. Lee K, Wucherpfennig K, Wiley D. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol. 2001;2:501-7 pubmed
    ..Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes. ..
  88. Wang S, Wheeler C, Hildesheim A, Schiffman M, Herrero R, Bratti M, et al. Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica. J Infect Dis. 2001;184:1310-4 pubmed
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection. ..
  89. Tang J, Penman Aguilar A, Lobashevsky E, Allen S, Kaslow R. HLA-DRB1 and -DQB1 alleles and haplotypes in Zambian couples and their associations with heterosexual transmission of HIV type 1. J Infect Dis. 2004;189:1696-704 pubmed
    ..Overall, associations of HLA class II polymorphisms with both HIV transmission and acquisition are not as readily interpretable as are effects reported for other loci. ..
  90. Kupila A, Muona P, Simell T, Arvilommi P, Savolainen H, Hämäläinen A, et al. Feasibility of genetic and immunological prediction of type I diabetes in a population-based birth cohort. Diabetologia. 2001;44:290-7 pubmed
    ..Families adhere well to the frequent measurement of signs of beta-cell autoimmunity in the children at-risk. ..