HLA-DQB1

Summary

Gene Symbol: HLA-DQB1
Description: major histocompatibility complex, class II, DQ beta 1
Alias: CELIAC1, HLA-DQB, IDDM1, HLA class II histocompatibility antigen, DQ beta 1 chain, MHC DQ beta, MHC class II DQ beta chain, MHC class II HLA-DQ beta glycoprotein, MHC class II antigen DQB1, MHC class II antigen HLA-DQ-beta-1, MHC class2 antigen, lymphocyte antigen
Species: human

Top Publications

  1. ncbi Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    S Mallal
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia
    Lancet 359:727-32. 2002
  2. pmc Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
  3. doi HLA-Class II in Latin American patients with type 1 diabetes
    Adriana Rojas-Villarraga
    Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 9:666-73. 2010
  4. ncbi HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination
    Chengbin Wang
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Hepatology 39:978-88. 2004
  5. doi Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes
    Hakbany Manan
    Department of Physiology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Hum Immunol 71:1238-42. 2010
  6. pmc GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma
    Karin E Smedby
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 7:e1001378. 2011
  7. doi IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 70:706-10. 2009
  8. pmc Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 58:1028-33. 2009
  9. ncbi Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population
    K W Lee
    Hallym Institution for Genome Application, Hallym University, Sacred Heart Hospital, 896 Pyungchon Dong, Dongan Ku, Anyang, Kyungki Do 431 070, Korea
    Tissue Antigens 65:437-47. 2005
  10. ncbi The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Italy
    Tissue Antigens 56:515-21. 2000

Research Grants

  1. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
  2. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2001
  3. TYROSINE PROTEIN KINASES AND LYMPHOCYTE ACTIVATION
    ROBERT GEAHLEN; Fiscal Year: 1993
  4. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2006
  5. Anti-CTLA-4 Monoclonal Antibody Therapy for Lymphoma
    John Timmerman; Fiscal Year: 2005
  6. Degeneracy and Complexity in the Immune System
    Eli Sercarz; Fiscal Year: 2006
  7. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2010
  8. ATM FUNCTION DURING V(D)J RECOMBINATION
    BARRY SLECKMAN; Fiscal Year: 2009
  9. ATM FUNCTION DURING V(D)J RECOMBINATION
    BARRY SLECKMAN; Fiscal Year: 2009
  10. ATM FUNCTION DURING V(D)J RECOMBINATION
    Barry P Sleckman; Fiscal Year: 2011

Detail Information

Publications260 found, 100 shown here

  1. ncbi Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir
    S Mallal
    Centre for Clinical Immunology and Biomedical Statistics, Royal Perth Hospital and Murdoch University, Western Australia, Perth, Australia
    Lancet 359:727-32. 2002
    ..Genetic factors influencing the immune response to abacavir might confer susceptibility. We aimed to find associations between MHC alleles and abacavir hypersensitivity in HIV-1-positive individuals treated with abacavir...
  2. pmc Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32
    Lucia Conde
    School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Nat Genet 42:661-4. 2010
    ..We also found confirmatory evidence of a previously reported association between chronic lymphocytic leukemia/small lymphocytic lymphoma and rs735665 (combined P = 4.24 x 10(-9))...
  3. doi HLA-Class II in Latin American patients with type 1 diabetes
    Adriana Rojas-Villarraga
    Center for Autoimmune Diseases Research, Universidad del Rosario, Bogota, Colombia
    Autoimmun Rev 9:666-73. 2010
    ..To identify and estimate the common effect size of HLA-Class II contributing to susceptibility on T1D in Latin America (LA) through a meta-analysis...
  4. ncbi HLA and cytokine gene polymorphisms are independently associated with responses to hepatitis B vaccination
    Chengbin Wang
    Department of Epidemiology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Hepatology 39:978-88. 2004
    ..In conclusion, DRB1*07 (or a closely linked allele) and immunoregulatory cytokine gene polymorphisms correlate with variable immune response to recombinant HBV vaccines...
  5. doi Genetic and diabetic auto-antibody markers in Saudi children with type 1 diabetes
    Hakbany Manan
    Department of Physiology, College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia
    Hum Immunol 71:1238-42. 2010
    ..In conclusion, these results show a strong association of HLA-DQB1*0201/0302 and DRB1*03/04 with T1DM. Thus, combining genetic markers with autoantibody is useful in a screening program for early detection of T1DM among Saudi children...
  6. pmc GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma
    Karin E Smedby
    Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    PLoS Genet 7:e1001378. 2011
    ..These findings suggest that the HLA class II region plays a complex yet important role in NHL...
  7. doi IFIH1 gene polymorphisms in type 1 diabetes: genetic association analysis and genotype-phenotype correlation in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 70:706-10. 2009
    ..76, p = 0.19) and no interaction with HLA-DQ-linked risk. Furthermore, no genotype-phenotype correlation was observed. In conclusion, IFIH1 has no important role in T1D risk assessment in a registry-based Belgian population...
  8. pmc Do non-HLA genes influence development of persistent islet autoimmunity and type 1 diabetes in children with high-risk HLA-DR,DQ genotypes?
    Andrea K Steck
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, Colorado, USA
    Diabetes 58:1028-33. 2009
    ..We examined whether some of these alleles influence development of islet autoimmunity or progression from persistent islet autoimmunity to type 1 diabetes in children with high-risk HLA-DR,DQ genotypes...
  9. ncbi Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population
    K W Lee
    Hallym Institution for Genome Application, Hallym University, Sacred Heart Hospital, 896 Pyungchon Dong, Dongan Ku, Anyang, Kyungki Do 431 070, Korea
    Tissue Antigens 65:437-47. 2005
    ..Information obtained in this study will be useful for medical and forensic applications as well as in anthropology...
  10. ncbi The distribution of HLA class II haplotypes reveals that the Sardinian population is genetically differentiated from the other Caucasian populations
    R Lampis
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Cagliari, Italy
    Tissue Antigens 56:515-21. 2000
    ....
  11. ncbi Interleukin-12p40 gene (IL-12B) polymorphism and Type 1 diabetes mellitus in Japanese: possible role in subjects without having high-risk HLA haplotypes
    Jian Mei Yang
    Division of Endocrinology and Metabolism, Department of Medicine, Jichi Medical School, Yakushiji 3311 1, Minamikawachi, Tochigi 329 0498, Japan
    Diabetes Res Clin Pract 71:164-9. 2006
    ..The IL-12B 3'UTR A-C polymorphism would be considered as a supplementary risk factor to T1DM in conjunction with HLA haplotypes...
  12. doi Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk
    Sabina Resic-Lindehammer
    Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, University Hospital MAS, CRC Lund University, Ent 72 Bldg 91 Floor 10, 205 02 Malmo, Sweden
    Acta Diabetol 45:231-5. 2008
    ..0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk...
  13. doi Human leukocyte antigen-DQ alleles and haplotypes and their associations with resistance and susceptibility to HIV-1 infection
    Rae Anne Hardie
    Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada
    AIDS 22:807-16. 2008
    ..To determine the association of DQ antigens with resistance and susceptibility to HIV-1...
  14. pmc Trends in high-risk HLA susceptibility genes among Colorado youth with type 1 diabetes
    Kendra Vehik
    University of Colorado Denver, School of Medicine, Denver, Colorado, USA
    Diabetes Care 31:1392-6. 2008
    ....
  15. ncbi Residual insulin secretion at diagnosis of type 1 diabetes is independently associated with both, age of onset and HLA genotype
    A Petrone
    Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy
    Diabetes Metab Res Rev 21:271-5. 2005
    ..We investigated whether residual insulin secretion and metabolic derangement at diagnosis of type 1 diabetes (T1DM) are influenced by human leukocyte antigens (HLA) class II genes...
  16. ncbi Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis
    Lisa F Barcellos
    Division of Epidemiology, School of Public Health, University of California, Berkeley 94720, USA, and Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, UK
    Hum Mol Genet 15:2813-24. 2006
    ....
  17. doi Genetic association of HLA DQB1 with CD4+CD25+(high) T-cell apoptosis in type 1 diabetes
    S Glisic
    Department of Pediatrics, Max McGee National Center for Juvenile Diabetes and Human Molecular Genetic Center, Medical College of Wisconsin, Children s Hospital of Wisconsin, Milwaukee, WI 53226, USA
    Genes Immun 10:334-40. 2009
    Type 1 diabetes (T1D) has a strong genetic component and the major locus lies in the HLA DQB1 region...
  18. doi Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes
    Caroline Brorsson
    Hagedorn Research Institute and Steno Diabetes Center, Gentofte, Denmark
    Autoimmunity 44:107-14. 2011
    ....
  19. ncbi Endocytosis of endogenously synthesized HIV-1 envelope protein. Mechanism and role in processing for association with class II MHC
    J F Rowell
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Immunol 155:473-88. 1995
    ....
  20. doi HLA-DPB1 associations differ between DRB1*03 positive anti-Jo-1 and anti-PM-Scl antibody positive idiopathic inflammatory myopathy
    Hector Chinoy
    Centre for Integrated Genomic Medical Research, University of Manchester, UK
    Rheumatology (Oxford) 48:1213-7. 2009
    ..The HLA-DPB1 gene is centromeric to other HLA class II loci and separated by a recombination hotspot. We investigated whether HLA-DPB1 associations differ between anti-Jo-1 and anti-PM-Scl antibody-positive IIM cases...
  21. pmc Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1)
    Vincent Butty
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:2348-59. 2008
    ....
  22. ncbi HLA class I (A, B, C) and class II (DRB1, DQA1, DQB1, DPB1) alleles and haplotypes in the Han from southern China
    E Trachtenberg
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Tissue Antigens 70:455-63. 2007
    ....
  23. ncbi Differences in the contribution of HLA-DR and -DQ haplotypes to susceptibility to adult- and childhood-onset type 1 diabetes in Japanese patients
    Satoshi Murao
    Matsuyama Shimin Hospital, Ehime, Japan
    Diabetes 53:2684-90. 2004
    ....
  24. ncbi New HLA haplotype frequency reference standards: high-resolution and large sample typing of HLA DR-DQ haplotypes in a sample of European Americans
    W Klitz
    Children s Hospital Oakland Research Institute, Oakland, CA, USA
    Tissue Antigens 62:296-307. 2003
    ..Four DQA1-DQB1 haplotypes, all rare, are reported here for the first time. The haplotype frequency tables are suitable as a reference standard for HLA typing of the DR and DQ loci in European Americans...
  25. ncbi HLA class II haplotype and autoantibody associations in children with juvenile dermatomyositis and juvenile dermatomyositis-scleroderma overlap
    L R Wedderburn
    Rheumatology Unit, Institute of Child Health, UCL, 30 Guilford Street, London WC1N 1EH, UK
    Rheumatology (Oxford) 46:1786-91. 2007
    ..To investigate a large cohort of children with juvenile dermatomyositis (JDM), and those with JDM-scleroderma (JDM-SSc) overlap, using detailed serological analysis, HLA class II genotyping and clinical characterization...
  26. pmc Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups
    E Mignot
    Center for Narcolepsy, Stanford University, Department of Psychiatry and Behavioral Sciences, Palo Alto, CA 94304, USA
    Am J Hum Genet 68:686-99. 2001
    ..Together with the recent hypocretin discoveries, these findings are consistent with an immunologically mediated destruction of hypocretin-containing cells in human narcolepsy-cataplexy...
  27. ncbi MHC susceptibility genes to IgA deficiency are located in different regions on different HLA haplotypes
    Emilio G De la Concha
    Department of Immunology, Hospital Clinico San Carlos, La Paz Hospital, 28040 Madrid, Spain
    J Immunol 169:4637-43. 2002
    ....
  28. pmc Diabetes-specific HLA-DR-restricted proinflammatory T-cell response to wheat polypeptides in tissue transglutaminase antibody-negative patients with type 1 diabetes
    Majid Mojibian
    Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, Canada
    Diabetes 58:1789-96. 2009
    ..However, questions arise regarding the frequency of abnormal immune responses to wheat and their nature, and it remains unclear whether such responses are diabetes specific...
  29. ncbi Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    Susan M McKiernan
    Hepatology Center, St James s Hospital and Trinity College, Dublin, Ireland
    Hepatology 40:108-14. 2004
    ..More significantly, either HLA-A*03, -DRB1*0101, or -*0401 are carried by an overwhelming majority of those subjects who successfully clear HCV...
  30. ncbi Killer cell immunoglobulin-like receptor genes in Latvian patients with type 1 diabetes mellitus and healthy controls
    Liene Nikitina-Zake
    Immunogenetics, Molecular Medicine, L8 00, Karolinska Hospital, Karolinska Institutet, 17176 Stockholm, Sweden
    Ann N Y Acad Sci 1037:161-9. 2004
    ..3), was higher. The maximum risk was when KIR2DL2, MICA5, and DR3/DR4 were in combination. In conclusion, our results suggest that a balance between innate and acquired immunity is important, and an imbalance coud lead to T1DM...
  31. doi Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies
    Ahmed J Delli
    Department of Clinical Sciences, Lund University, Malmo, Sweden
    Pediatr Diabetes 11:513-20. 2010
    ..We also determined whether they have different human leukocyte antigen (HLA) genetic markers and islet autoantibodies at diagnosis compared with Swedish patients...
  32. pmc HLA class I and genetic susceptibility to type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Janelle A Noble
    Children s Hospital Oakland Research Institute, Oakland, California, USA
    Diabetes 59:2972-9. 2010
    ..We report here genotyping data and type 1 diabetes association analyses for HLA class I loci (A, B, and C) on 1,753 multiplex pedigrees from the Type 1 Diabetes Genetics Consortium (T1DGC), a large international collaborative study...
  33. ncbi A study of the diagnostic utility of HLA typing, CSF hypocretin-1 measurements, and MSLT testing for the diagnosis of narcolepsy in 163 Korean patients with unexplained excessive daytime sleepiness
    Seung Chul Hong
    Department of Neuropsychiatry, St Vincent s Hospital, Catholic University of Korea, Suwon, Korea
    Sleep 29:1429-38. 2006
    ....
  34. ncbi Non-class II HLA gene associated with type 1 diabetes maps to the 240-kb region near HLA-B
    S Nejentsev
    Juvenile Diabetes Foundation Center for Type 1 Diabetes Prevention in Finland, Turku
    Diabetes 49:2217-21. 2000
    ..Our data indicate that an additional gene associated with type 1 diabetes is located in the 240-kb region near HLA-B. We excluded STR MICA polymorphism as a mutation responsible for diabetes association...
  35. ncbi HLA in Czech adult patients with autoimmune diabetes mellitus: comparison with Czech children with type 1 diabetes and patients with type 2 diabetes
    M Cerna
    Department of Cell and Molecular Biology, Third Medical Faculty of Charles University, Prague, Czech Republic
    Eur J Immunogenet 30:401-7. 2003
    ..Type 1 diabetes mellitus (DM) in children or adults may have partly different immunogenetic etiopathogenesis than LADA...
  36. ncbi VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile
    Diego Garcia
    Genetic Epidemiology Laboratory, Nutrition and Food Technology Institute, University of Chile, Santiago, Chile
    Diabetes Res Clin Pract 77:134-40. 2007
    ....
  37. pmc Latent autoimmune diabetes in adults differs genetically from classical type 1 diabetes diagnosed after the age of 35 years
    Mette K Andersen
    Research Program for Molecular Medicine, Helsinki University, Helsinki, Finland
    Diabetes Care 33:2062-4. 2010
    ..We studied differences between patients with latent autoimmune diabetes in adults (LADA), type 2 diabetes, and classical type 1 diabetes diagnosed after age 35 years...
  38. ncbi Contribution of selective HLA-DRB1/DQB1 alleles and haplotypes to the genetic susceptibility of type 1 diabetes among Lebanese and Bahraini Arabs
    Fayza A Al-Jenaidi
    Al Jawhara Center for Molecular Medicine, Genetics, and Inherited Diseases, College of Medicine and Medical Sciences, Arabian Gulf University, P O Box 22979, Manama, Bahrain
    J Clin Endocrinol Metab 90:5104-9. 2005
    ....
  39. ncbi Genetic screening for individuals at high risk for type 1 diabetes in the general population using HLA Class II alleles as disease markers. A comparison between three European populations with variable rates of disease incidence
    R Hermann
    JDRF Center for Prevention of Type I Diabetes in Finland, University of Turku, Turku, Finland
    Diabetes Metab Res Rev 20:322-9. 2004
    ..To develop screening strategies for identification of individuals at increased genetic risk for type 1 diabetes in three populations with variable disease incidence rates and distinct ethnic origin...
  40. ncbi Concordance for type 1 diabetes in identical twins is affected by insulin genotype
    K A Metcalfe
    Department of Diabetes and Metabolic Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary and Westfield College, University of London, UK
    Diabetes Care 24:838-42. 2001
    ..The aim of this study was to determine whether two susceptibility genes were less prevalent in discordant twins compared with concordant twins...
  41. pmc Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoire
    Menno van Lummel
    Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands
    J Biol Chem 287:9514-24. 2012
    ..Our findings provide a molecular basis for the association between HLA-DQ transdimers and T1D and set the stage for rational testing of potential diabetogenic peptide epitopes...
  42. pmc The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies
    M Maziarz
    Department of Biostatistics, University of Washington, Seattle, WA 98195 7232, USA
    Genes Immun 11:406-15. 2010
    ..We hypothesize that the altered T-cell function because of the PTPN22(1858C>T) polymorphism is exclusively associated with GADA-positive T1D at diagnosis...
  43. doi An inverse association between history of childhood eczema and subsequent risk of type 1 diabetes that is not likely to be explained by HLA-DQ, PTPN22, or CTLA4 polymorphisms
    Lars C Stene
    Division of Epidemiology, Norwegian Institute of Public Health, NO 0403 Oslo, Norway
    Pediatr Diabetes 11:386-93. 2010
    ....
  44. doi Polymorphisms of CXCR3-binding chemokines in type 1 diabetes
    Patrick Bruck
    Department of Internal Medicine IV, Division of Haematology and Oncology, University Hospital Giessen and Marburg, Germany
    Hum Immunol 70:552-5. 2009
    ..Although we did not find an association of the CXCL9 and CXCL10 polymorphisms with type 1 diabetes in the German population, we cannot discard their role in other populations or other autoimmune diseases...
  45. doi From Type 1, through LADA, to type 2 diabetes: a continuous spectrum?
    J Lin
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China
    Ann N Y Acad Sci 1150:99-102. 2008
    ..The preliminary data demonstrated that the susceptible haplotypes of the HLA-DQ gene present a continuous spectrum from typical T1DM, through LADA, to T2DM, which deserves further investigation...
  46. pmc Nephropathy in type 1 diabetes is diminished in carriers of HLA-DRB1*04: the genetics of kidneys in diabetes (GoKinD) study
    Suzanne K Cordovado
    Centers for Disease Control and Prevention, 4770 Buford Hwy, MS F 24, Atlanta, GA 30341, USA
    Diabetes 57:518-22. 2008
    ..The availability of phenotypic and genotypic data on GoKinD participants allowed a detailed analysis of the association of these genes with diabetic nephropathy...
  47. ncbi The role of HLA molecules in susceptibility to chronic rheumatic heart disease
    H Kudat
    Department of Cardiology, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    Int J Immunogenet 33:41-4. 2006
    ..The HLA-DRB1*13, DRB5* and DRB3* were protective against the development of rheumatic valve damage...
  48. ncbi The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1
    Zaheed Husain
    Immune Disease Institute, 800 Huntington Avenue, Boston, MA 02115, USA
    J Autoimmun 30:266-72. 2008
    ....
  49. ncbi HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk prediction
    A G Rohana
    Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
    Med J Malaysia 66:133-7. 2011
    ..The lower incidence of type 1 DM in the Malay population may be contributed by the genotypic combinations of DR and DQ genes as well as the linkage disequilibria between susceptible and protective alleles...
  50. ncbi NEUROD polymorphism Ala45Thr is associated with Type 1 diabetes mellitus in Czech children
    Ondrej Cinek
    Second Department of Paediatrics, Second Faculty of Medicine, Charles University, V Uvalu 84, Prague 5 CZ 150 06, Czech Republic
    Diabetes Res Clin Pract 60:49-56. 2003
    ..No association was observed for the Pro197His mutation which was carried by 5.3% cases and 5.9% controls. Our results confirm that the NEUROD Ala45Thr polymorphism is associated with childhood-onset Type 1 DM...
  51. pmc Predictors of associated autoimmune diseases in families with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium
    Ana M Wägner
    Endocrinology Department, Complejo Hospitalario Universitario Insular Materno Infantil, de Gran Canaria, Spain
    Diabetes Metab Res Rev 27:493-8. 2011
    ..The aim of this study was to find predictors of AAIDs in the Type 1 Diabetes Genetics Consortium data set...
  52. doi Association of IL-2RA/CD25 with type 1 diabetes in the Belgian population
    Folefac Aminkeng
    Diabetes Research Center, Faculty of Medicine and Pharmacy, Brussels Free University Vrije Universiteit Brussel VUB, Brussels, Belgium
    Hum Immunol 71:1233-7. 2010
    ..015). In conclusion, IL-2RA/CD25 is associated with type 1 diabetes in the Belgian population, independently of disease phenotype and other biologic markers...
  53. ncbi Risk of celiac disease in children with type 1 diabetes is modified by positivity for HLA-DQB1*02-DQA1*05 and TNF -308A
    Zdenek Sumnik
    Motol University Hospital, Charles University Prague, V Uvalu 84, CZ 150 06, Prague, The Czech Republic
    Diabetes Care 29:858-63. 2006
    ....
  54. doi Age-related islet autoantibody incidence in offspring of patients with type 1 diabetes
    A G Ziegler
    Institute of Diabetes Research, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Diabetologia 55:1937-43. 2012
    ..Seroconversion to islet autoantibodies precedes type 1 diabetes. This study aimed to identify periods of high seroconversion incidence, which could be targeted for mechanistic and therapeutic studies...
  55. doi HLA-DR-DQ haplotypes and type 1 diabetes in Macedonia
    Jorma Ilonen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Hum Immunol 70:461-3. 2009
    ....
  56. ncbi Immunogenetics of HLA class II in Israeli patients with adult-onset type 1 diabetes mellitus
    Dania Hirsch
    Department of Endocrinology, Rabin Medical Center, Beilinson Campus, Petah Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Immunol 68:616-22. 2007
    ..It may be concluded that the different ages of onset of T1D and its different forms of development in Israeli patients are apparently not caused by a different prevalence of HLA class II alleles...
  57. ncbi Type 1 diabetes in Jewish Ethiopian immigrants in Israel: HLA class II immunogenetics and contribution of new environment
    A Zung
    Pediatric Endocrinology Unit, Kaplan Medical Center, Rehovot, Israel
    Hum Immunol 65:1463-8. 2004
    ..621, p = 0.04). We concluded that ongoing exposure of genetically predisposed immigrants from Ethiopia to diabetogenic environmental factors eventually leads to a high incidence of overt diabetes in this ethnic group...
  58. doi Variations of the perforin gene in patients with type 1 diabetes
    Elisabetta Orilieri
    Interdisciplinary Research Center of Autoimmune Diseases and Department of Medical Sciences, A Avogadro University of Eastern Piedmont, Novara, Italy
    Diabetes 57:1078-83. 2008
    ..The aim of this work was to investigate the role of PRF1 variations in type 1 diabetes...
  59. pmc MHC class II, tumour necrosis factor alpha, and lymphotoxin alpha gene haplotype associations with serological subsets of systemic lupus erythematosus
    N J McHugh
    Royal National Hospital for Rheumatic Diseases, Upper Borough Walls, Bath, Somerset BA1 1RL UK
    Ann Rheum Dis 65:488-94. 2006
    ..To conduct a case-control study to investigate whether there are independent tumour necrosis factor alpha (TNFalpha) or lymphotoxin alpha (LTalpha) haplotype associations with SLE or with any of the major serological subsets of SLE...
  60. ncbi Does HLA genotype influence the relative risk of Type 1 diabetes conferred by dietary factors?
    L C Stene
    Diabet Med 19:429-31. 2002
  61. ncbi L-selectin gene T668C mutation in type 1 diabetes patients and their first degree relatives
    A Kretowski
    Department of Endocrinology, Medical School Biatystok, U1 M C Skl and z shtsls odowska Curie 24 a, 15 267, Bial and z shtsls ystok, Poland
    Immunol Lett 74:225-8. 2000
    ..highest frequency of F206L mutation in the EGF domain of L-selectin was observed in relatives with 'protective' HLA DQB1*0602 allele and nonDRB1*03-nonDRB1*04 haplotype, while in subjects with highest risk of IDDM haplotype the ..
  62. ncbi MICA-A5.1 allele is associated with atypical forms of celiac disease in HLA-DQ2-negative patients
    Antonio Lopez-Vazquez
    Department of Immunology, Hospital Central de Asturias, C Celestino Villamil, 33 006 Oviedo, Spain
    Immunogenetics 53:989-91. 2002
    ..002). No other MICA allele was found to be significantly increased in the groups under study. The presence of MICA-A5.1 in atypical CD DQ2-negative patients may indicate a possible role of this allele in the development of CD...
  63. pmc HLA genotyping in the international Type 1 Diabetes Genetics Consortium
    Josyf C Mychaleckyj
    Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA
    Clin Trials 7:S75-87. 2010
    ....
  64. pmc Autoimmune type 1 diabetes genetic susceptibility encoded by human leukocyte antigen DRB1 and DQB1 genes in Tunisia
    Mouna Stayoussef
    Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
    Clin Vaccine Immunol 16:1146-50. 2009
    ....
  65. ncbi HLA-DRB1 and MHC class 1 chain-related A haplotypes in Basque families with celiac disease
    J R Bilbao
    Endocrinology and Diabetes Research Unit, Hospital de Cruces, Barakaldo, Basque Country, Spain
    Tissue Antigens 60:71-6. 2002
    ..Finally, the major histocompatibility complex region's conferred susceptibility to CD, at least in Basque, is very similar to that observed for DM1, with shared risk and protective haplotypes...
  66. ncbi The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjects
    Jan E van Autreve
    Diabetes Research Center, Molecular Diagnosis, Vrije Universteit Brussel, B 1070 Brussels, Belgium
    Hum Immunol 65:729-36. 2004
    ..These results are compatible with an effect of cis-encoded heterodimers or with previously suggested interactions of X-linked genetic factors with (DR3-)DQB1*02 haplotypes...
  67. doi The type 1 diabetes protective HLA DQB1*0602 allele is less frequent in gestational diabetes mellitus
    A Papadopoulou
    Department of Clinical Sciences, Unit of Diabetes and Celiac Disease, Lund University CRC, Malmo, Sweden
    Diabetologia 52:1339-42. 2009
    ..We tested whether gestational diabetes mellitus (GDM) is associated with HLA-DQ genotypes...
  68. doi Reproducible association with type 1 diabetes in the extended class I region of the major histocompatibility complex
    M K Viken
    Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Genes Immun 10:323-33. 2009
    ..Taken together, our results identify PRSS16 and BTN3A2, two genes thought to play important roles in regulating the immune response, as potentially novel susceptibility genes for T1D...
  69. ncbi Reciprocal modulation of transcriptional activities between HIV-1 Tat and MHC class II transactivator CIITA
    H Okamoto
    Department of Molecular Genetics, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, Aichi, 467 8601, Japan
    Biochem Biophys Res Commun 279:494-9. 2000
    ..These reciprocal actions between Tat and CIITA not only explains the functional impairment of APC in HIV-1 infection but also rationalizes the suppression of HIV-1 virus load by induction of CIITA such as IFN-gamma...
  70. ncbi Human leukocyte antigen non-class II determinants for type 1 diabetes in the Finnish population
    Zsofia Gombos
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Hum Immunol 67:714-21. 2006
    ..Another locus close to D6S273 may also have an effect. For the first time we report that a locus near the C143 marker appear to affect disease association of the DRB1*08-DQB1*04 haplotype...
  71. pmc Homozygosity of the polymorphism MICA5.1 identifies extreme risk of progression to overt adrenal insufficiency among 21-hydroxylase antibody-positive patients with type 1 diabetes
    Taylor M Triolo
    Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Health Science Center, Aurora, CO 80045, USA
    J Clin Endocrinol Metab 94:4517-23. 2009
    ..Subjects with type 1 diabetes (T1D) are at increased risk for AD. Genetic factors including HLA-DRB1*0404 and MICA have been associated with AD in populations with and without T1D...
  72. ncbi HLA-DRB1, DQB1, and DQA1 allele profile in Brazilian patients with type 1 diabetes mellitus
    A P M Fernandes
    Department of General and Specialized Nursing, School of Nursing of Ribeirao Preto, University of Sao Paulo, 14 049 902, Ribeirao Preto, Sao Paulo, Brazil
    Ann N Y Acad Sci 958:305-8. 2002
    ..In addition to HLA-DRB1*15 and DQB1*0602 alleles, DRB1*11, DRB1*13, and DQA1*01 allele groups were associated with protection against the development of type 1 diabetes in Brazilian patients...
  73. ncbi Differences in idiopathic inflammatory myopathy phenotypes and genotypes between Mesoamerican Mestizos and North American Caucasians: ethnogeographic influences in the genetics and clinical expression of myositis
    Ejaz A Shamim
    Center for Biologics Evaluation and Research, FDA, Bethesda, Maryland, USA
    Arthritis Rheum 46:1885-93. 2002
    ....
  74. ncbi TNFa microsatellite polymorphism modulates the risk of type 1 diabetes in the Belgian population, independent of HLA-DQ
    Folefac Aminkeng
    Diabetes Research Center, Molecular Diagnosis Unit, Vrije Universiteit Brussel, Brussels, Belgium
    Hum Immunol 68:690-7. 2007
    ....
  75. ncbi Fetal growth is increased by maternal type 1 diabetes and HLA DR4-related gene interactions
    M Hummel
    Institute of Diabetes Research and Academic Hospital Schwabing, Kolner Platz 1, 80804, Munchen, Germany
    Diabetologia 50:850-8. 2007
    ..The aim of this study was to determine whether HLA DR4 was associated with increased birthweight in a maternal diabetes environment and whether effects persisted during early childhood...
  76. pmc Effect of HLA class I and class II alleles on progression from autoantibody positivity to overt type 1 diabetes in children with risk-associated class II genotypes
    Kati Lipponen
    Immunogenetics Laboratory, University of Turku, Turku, Finland
    Diabetes 59:3253-6. 2010
    ..To test this hypothesis we analyzed the role of HLA class I and class II gene polymorphisms in the progression from diabetes-associated autoimmunity to clinical disease...
  77. ncbi HLA-DRB1, -DQA1, and -DQB1 subtypes or ACE gene polymorphisms do not seem to be risk markers for severe retinopathy in younger Type 1 diabetic patients
    Elisabet Agardh
    Department of Ophthalmology, University Hospital MAS, SE 205 02 Malmo, Sweden
    J Diabetes Complications 18:32-6. 2004
    ....
  78. ncbi Human leukocyte antigen class I and class II allele frequencies and HIV-1 infection associations in a Chinese cohort
    Shu Li
    Vaccine Laboratory, Nankai University, Tianjin, China
    J Acquir Immune Defic Syndr 44:121-31. 2007
    ..These data contribute to the database of allele frequencies and associations with HIV infection in the Chinese population...
  79. doi Genetic variants of the HLA-A, HLA-B and AIF1 loci show independent associations with type 1 diabetes in Norwegian families
    M C Eike
    Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    Genes Immun 10:141-50. 2009
    ..Our results illustrate the importance of a comprehensive adjustment for LD effects when performing association studies in this complex...
  80. pmc In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype
    Hector Chinoy
    Rheumatic Diseases Centre, Hope Hospital, Salford, UK
    Arthritis Res Ther 8:R13. 2006
    ..In conclusion, these findings support the notion that myositis patients with differing myositis serology have different immunogenetic profiles, and that these profiles may define specific myositis subtypes...
  81. pmc Crystal structure of HLA-DQ0602 that protects against type 1 diabetes and confers strong susceptibility to narcolepsy
    Christian Siebold
    Division of Structural Biology, The Henry Wellcome Building for Genomic Medicine, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, United Kingdom
    Proc Natl Acad Sci U S A 101:1999-2004. 2004
    ..In narcolepsy, the volume of the P4 pocket appears central to the susceptibility, suggesting that the presentation of a specific peptide population plays a major role...
  82. ncbi Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
    K H Lee
    Laboratory of Molecular Medicine, The Department of Medicine, The Children s Hospital, 320 Longwood Avenue, Boston, MA 02115, USA
    Nat Immunol 2:501-7. 2001
    ..Correlating type 1 diabetes epidemiology and MHC sequences with the DQ8 structure suggests that other structural features of the P9 pocket in addition to position 57 contribute to susceptibility to type 1 diabetes...
  83. pmc Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans
    Rebecca A Harris
    Division of Gastroenterology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19014, USA
    Hepatology 48:70-9. 2008
    ..005; DQB1*03-DRB3*02: OR, 13.5, P = 0.001) but not among African American patients. Furthermore, although HLA DQB1*03, DRB1*11, and DRB3*02 genotypes were associated with increased HCV-specific CD4 T cell response in univariate ..
  84. ncbi HLA-DQ polymorphisms modify the risk of thyroid autoimmunity in children with type 1 diabetes mellitus
    Z Sumnik
    2nd Department of Pediatrics, 2nd Medical School, Charles University, Prague, Czech Republic
    J Pediatr Endocrinol Metab 16:851-8. 2003
    ..PATIENTS AND METLHODS: Screening for TAI was performed in 285 children with DM1 by measuring autoantibodies against thyroid peroxidase (anti-TPO) and thyroglobulin (anti-Tg). HLA-DQA1 and -DQB1 were genotyped using PCR-SSP...
  85. ncbi Molecular basis of predisposition to develop type 1 diabetes mellitus in North Indians
    R Rani
    Neuroimmunology Laboratory, National Institute of Immunology, Aruna Asafali Marg, New Delhi, India
    Tissue Antigens 64:145-55. 2004
    ..31 (IDDM1) has been the major contributor, followed by 5' regulatory region of the insulin (INS) gene on chromosome 11p15...
  86. ncbi HLA polymorphism in the Murcia population (Spain): in the cradle of the archaeologic Iberians
    M Muro
    Service of Immunology, University Hospital Virgen de la Arrixaca, Murcia, Spain
    Hum Immunol 62:910-21. 2001
    ..Thus, Murcian population seems to belong to the European genetic pool, revealing a lesser genetic distance with the North Africans and the rest of populations from the Iberian Peninsula...
  87. pmc An association analysis of the HLA gene region in latent autoimmune diabetes in adults
    M Desai
    Diabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford, OX3 7LJ, UK
    Diabetologia 50:68-73. 2007
    ..Our aim was to define patterns of HLA-encoded susceptibility/protection in a large, well characterised LADA cohort, and to establish association with disease and age at diagnosis...
  88. ncbi Human leukocyte antigen class I and II alleles and risk of cervical neoplasia: results from a population-based study in Costa Rica
    S S Wang
    Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892 7234, USA
    J Infect Dis 184:1310-4. 2001
    ..2-23.7). These results support the hypothesis that multiple risk alleles are needed in order to increase risk for cervical neoplasia, but a single protective allele may be sufficient for protection...
  89. ncbi Screening of coeliac disease in north Italian children with type 1 diabetes: limited usefulness of HLA-DQ typing
    G Contreas
    Childhood Diabetes Unit, University of Verona, Verona, Italy
    Acta Paediatr 93:628-32. 2004
    ..To determine the contribution of HLA-DQA1* and HLA-DQB1* genes to the risk of coeliac disease (CD) in a cohort of children with type 1 diabetes mellitus (T1DM) from northern Italy...
  90. ncbi Genetic prediction of type 1 diabetes in a population with low frequency of HLA risk genotypes and low incidence of the disease (the DIABFIN study)
    R Buzzetti
    Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy
    Diabetes Metab Res Rev 20:137-43. 2004
    ....
  91. doi Frequencies of genetic polymorphisms of TLR4 and CD14 and of HLA-DQ genotypes in children with celiac disease, type 1 diabetes mellitus, or both
    A Dezsofi
    First Department of Pediatrics, Semmelweis University, Hungary
    J Pediatr Gastroenterol Nutr 47:283-7. 2008
    ....
  92. pmc Type 1 diabetes in the Spanish population: additional factors to class II HLA-DR3 and -DR4
    Elena Urcelay
    Immunology Department, Hospital Universitario San Carlos, Madrid, Spain
    BMC Genomics 6:56. 2005
    ..We aimed to corroborate whether this haplotype increases the susceptibility conferred by the DQ2-DR3 alleles in a Mediterranean population. We also searched for additional susceptibility factors to the classic DQ2-DR3 and DQ8-DR4...
  93. ncbi Possible human leukocyte antigen-mediated genetic interaction between type 1 and type 2 Diabetes
    H Li
    Diabetes and Endocrine Research Laboratory, Department of Endocrinology, Lund University, S 20502 Malmo, Sweden
    J Clin Endocrinol Metab 86:574-82. 2001
    ..The findings support a possible genetic interaction between type 1 and type 2 diabetes mediated by the HLA locus...
  94. pmc HLA and interleukin 1 gene polymorphisms in primary biliary cirrhosis: associations with disease progression and disease susceptibility
    P Donaldson
    Centre for Liver Research, 4th Floor Willliam Leech Building, University of Newcastle, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Gut 48:397-402. 2001
    ..PBC is heterogeneous and genetic associations with disease progression may be obscured when the PBC population is analysed only as a whole and not subdivided...
  95. doi Human leukocyte antigen-DR15, low infant sibling exposure and multiple sclerosis: gene-environment interaction
    Ingrid A F van der Mei
    Menzies Research Institute, University of Tasmania, Hobart, Tasmania, Australia
    Ann Neurol 67:261-5. 2010
    ..This suggests that immune mechanisms involving HLA class II molecules are susceptible to modulation in early life. Ann Neurol 2009;66:261-265 ANN NEUROL 2010;67:259-263...
  96. ncbi The co-inheritance of type 1 diabetes and multiple sclerosis in Sardinia cannot be explained by genotype variation in the HLA region alone
    Maria Giovanna Marrosu
    Centro Sclerosi Multipla, Dipartimento di Neuroscienze, University of Cagliari, Italy
    Hum Mol Genet 13:2919-24. 2004
    ..The data suggest that variation at other non-HLA class II loci, and/or unknown environmental factors contribute significantly to the co-occurrence of these two traits...
  97. ncbi Molecular genetic analysis of HLA-DR and -DQ alleles in Spanish patients with melanoma
    E Nagore
    Department of Dermatology, Instituto Valenciano de Oncologia, Valencia, Spain
    Acta Derm Venereol 82:90-3. 2002
    ..Our results indicate that HLA class II alleles may not contribute to a strong susceptibility to melanoma in the Spanish population, although further studies on larger series are needed to corroborate this. Key words:..
  98. ncbi The nonpolymorphic MHC class II isotype, HLA-DQA2, is expressed on the surface of B lymphoblastoid cells
    G B Rudy
    Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Australia
    J Immunol 158:2116-25. 1997
    ..In neither case was DQA2 found to dimerize with an MHC class II beta-chain. Despite this, DQA2 is capable of forming a complex with invariant chain...
  99. ncbi HLA class I and class II allele and haplotype diversity in Martinicans
    O Bera
    Laboratoire de Virologie Immunologie, CHU de Fort de France, Martinique
    Tissue Antigens 57:200-7. 2001
    ....
  100. ncbi Macrophages from high-risk HLA-DQB1*0201/*0302 type 1 diabetes mellitus patients are hypersensitive to lipopolysaccharide stimulation
    A Plesner
    Department of Medicine, University of Washington, Seattle Department of Veterans Affairs, Puget Sound Health Care System, Seattle, WA, USA
    Scand J Immunol 56:522-9. 2002
    ..interleukin (IL)-1beta, IL-6, IL-12 and prostaglandin E-2 (PGE-2) secretion from hetero- or homozygous HLA DQB1*0201 and *0302 type 1 diabetes mellitus patients, first-degree relatives and homozygous HLA DQB1*0602 healthy ..
  101. ncbi HLA class II DNA typing in a large series of European patients with systemic lupus erythematosus: correlations with clinical and autoantibody subsets
    Mauro Galeazzi
    Istituto di Reumatologia, Universita di Siena, Siena, Italy
    Medicine (Baltimore) 81:169-78. 2002

Research Grants63

  1. Dengue Epitope Vaccine,Tetravalent & MHCII-Targeted
    J Thomas August; Fiscal Year: 2007
    ..selected for binding to clusters of major histocompatability class (MHC) motifs representing multiple human lymphocyte antigen (HLA) alleles (promiscuous epitopes) and effective with each of the four dengue serotypes (pan-dengue ..
  2. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2001
    ..A subset of memory T cells bear a marker called cutaneous lymphocyte antigen (CLA) recognized by a unique monoclonal antibody HECA-452...
  3. TYROSINE PROTEIN KINASES AND LYMPHOCYTE ACTIVATION
    ROBERT GEAHLEN; Fiscal Year: 1993
    ..a novel protein-tyrosine kinase, PTK72, which is part of a signal transduction complex associated with the B lymphocyte antigen receptor...
  4. SKIN HOMING T CELLS--MOLECULAR CHARACTERIZATION OF CLA
    Thomas Kupper; Fiscal Year: 2006
    ..g., lung, gut). These markers include Cutaneous Lymphocyte antigen (CLA, a ligand for E and P selectin which we characterized extensively in the first cycle of funding), the ..
  5. Anti-CTLA-4 Monoclonal Antibody Therapy for Lymphoma
    John Timmerman; Fiscal Year: 2005
    ..T cell hyporesponsiveness towards tumors is blockade of the negative T cell regulatory molecule cytotoxic T lymphocyte antigen 4 (CTLA-4)...
  6. Degeneracy and Complexity in the Immune System
    Eli Sercarz; Fiscal Year: 2006
    ..Actually, most of the crucial receptor elements in the immune system, aside from lymphocyte antigen receptors, are degenerate to a great extent, e.g...
  7. Skin Homing T Cells -- Molecular Characterization of CLA
    Thomas S Kupper; Fiscal Year: 2010
    ..two funding cycles of this grant, we have characterized the molecular structure and function of Cutaneous Lymphocyte Antigen or CLA...
  8. ATM FUNCTION DURING V(D)J RECOMBINATION
    BARRY SLECKMAN; Fiscal Year: 2009
    ..We have shown that ATM is also involved in the repair of RAG-mediated DSBs generated during lymphocyte antigen receptor gene assembly...
  9. ATM FUNCTION DURING V(D)J RECOMBINATION
    BARRY SLECKMAN; Fiscal Year: 2009
    ..We have shown that ATM is also involved in the repair of RAG-mediated DSBs generated during lymphocyte antigen receptor gene assembly...
  10. ATM FUNCTION DURING V(D)J RECOMBINATION
    Barry P Sleckman; Fiscal Year: 2011
    ..We have shown that ATM is also involved in the repair of RAG-mediated DSBs generated during lymphocyte antigen receptor gene assembly...
  11. ATM FUNCTION DURING V(D)J RECOMBINATION
    Barry P Sleckman; Fiscal Year: 2010
    ..We have shown that ATM is also involved in the repair of RAG-mediated DSBs generated during lymphocyte antigen receptor gene assembly...
  12. GENETIC FACTORS AND SUSCEPTIBILITY TO TUBERCULOSIS
    Anne Goldfeld; Fiscal Year: 2001
    ..This aim will investigate whether there is an HLA association with anergy or lack of DTH, and will characterize the cytokine profiles and T cell proliferative responses in anergic pulmonary tuberculosis patients. ..
  13. SPONTANEOUS REGRESSION BIOMARKERS IN CERVIX DYSPLASIA
    Gloria Ho; Fiscal Year: 2003
    ..HPV types 6, 16, 18, 31, 53, and 58, (2) cell-mediated immunity (CMI) to HPV 16 E6 and E7 peptides, (3) class II HLA DQB1 and DRB1 alleles, (4) plasma ascorbic acid level, and (5) red blood cell (RBC) folate level...
  14. SIGNAL TRANSDUCTION IN B CELL ACTIVATION
    John Cambier; Fiscal Year: 2000
    B lymphocyte antigen receptors, membrane immunoglobulins (mIg), function in transduction of information across the plasma membrane leading to altered gene expression and cell activation, and in focussing and internalization of antigen for ..
  15. REGULATION OF TCRB CHAIN GENE REARRANGEMENT
    BARRY SLECKMAN; Fiscal Year: 2004
    DESCRIPTION (Adapted from the Investigator's abstract): Lymphocyte antigen receptor genes are assembled by a site-specific recombination process, referred to as V(D)J recombination, which is tightly regulated within the context of ..
  16. Developmental and genomic studies on the agnatha VLR system
    Chris Amemiya; Fiscal Year: 2007
    ..A lymphocyte antigen receptor system capable of generating enormous diversity via somatic rearrangement has recently been ..